calcium signaling

Summary

Summary: Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

Top Publications

  1. ncbi Calcium signaling
    David E Clapham
    Aldo R Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 131:1047-58. 2007
  2. ncbi Calcium signalling: dynamics, homeostasis and remodelling
    Michael J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Mol Cell Biol 4:517-29. 2003
  3. ncbi The versatility and universality of calcium signalling
    M J Berridge
    The Babraham Institute, Laboratory of Molecular Signalling, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    Nat Rev Mol Cell Biol 1:11-21. 2000
  4. ncbi Mitofusin 2 tethers endoplasmic reticulum to mitochondria
    Olga Martins de Brito
    Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
    Nature 456:605-10. 2008
  5. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
  6. pmc An expanded palette of genetically encoded Ca²⁺ indicators
    Yongxin Zhao
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Science 333:1888-91. 2011
  7. ncbi Regulation of cell death: the calcium-apoptosis link
    Sten Orrenius
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Nat Rev Mol Cell Biol 4:552-65. 2003
  8. pmc Glutamate-dependent neuroglial calcium signaling differs between young and adult brain
    Wei Sun
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Science 339:197-200. 2013
  9. ncbi Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    Nat Methods 1:31-7. 2004
  10. ncbi Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
    Kenichi Ohki
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 433:597-603. 2005

Detail Information

Publications380 found, 100 shown here

  1. ncbi Calcium signaling
    David E Clapham
    Aldo R Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 131:1047-58. 2007
    ..Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription...
  2. ncbi Calcium signalling: dynamics, homeostasis and remodelling
    Michael J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Mol Cell Biol 4:517-29. 2003
    ..Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease...
  3. ncbi The versatility and universality of calcium signalling
    M J Berridge
    The Babraham Institute, Laboratory of Molecular Signalling, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    Nat Rev Mol Cell Biol 1:11-21. 2000
    ..Exceeding its normal spatial and temporal boundaries can result in cell death through both necrosis and apoptosis...
  4. ncbi Mitofusin 2 tethers endoplasmic reticulum to mitochondria
    Olga Martins de Brito
    Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy
    Nature 456:605-10. 2008
    ..Thus, mitofusin 2 tethers ER to mitochondria, a juxtaposition required for efficient mitochondrial Ca(2+) uptake...
  5. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
    ..Furthermore, spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function...
  6. pmc An expanded palette of genetically encoded Ca²⁺ indicators
    Yongxin Zhao
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Science 333:1888-91. 2011
    ..This palette of indicators paints the way to a colorful new era of Ca(2+) imaging...
  7. ncbi Regulation of cell death: the calcium-apoptosis link
    Sten Orrenius
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Nat Rev Mol Cell Biol 4:552-65. 2003
    ..However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death...
  8. pmc Glutamate-dependent neuroglial calcium signaling differs between young and adult brain
    Wei Sun
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Science 339:197-200. 2013
    ..In contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages...
  9. ncbi Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    Nat Methods 1:31-7. 2004
    ..We expect SR101 staining to become a principal tool for investigating astroglia in vivo...
  10. ncbi Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
    Kenichi Ohki
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 433:597-603. 2005
    ..These results indicate that cortical maps can be built with single-cell precision...
  11. pmc STIM1, an essential and conserved component of store-operated Ca2+ channel function
    Jack Roos
    Torrey Pines Therapeutics, Inc, La Jolla, CA 92037, USA
    J Cell Biol 169:435-45. 2005
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels...
  12. pmc Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish
    Sa Kan Yoo
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Cell Biol 199:225-34. 2012
    ..In this paper, using zebrafish larval tail fins as a model, we find that wounding rapidly activated SFK and calcium signaling in epithelia...
  13. pmc In vivo two-photon calcium imaging of neuronal networks
    Christoph Stosiek
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 12, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 100:7319-24. 2003
    ..Thus, our results demonstrate the suitability of this technique for real-time analyses of intact neuronal circuits with the resolution of individual cells...
  14. pmc A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo
    Hatim A Zariwala
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 32:3131-41. 2012
    ..Our results show that the Ai38 reporter mouse provides a flexible method for targeted expression of GCaMP3...
  15. ncbi The mitochondrial calcium uniporter is a highly selective ion channel
    Yuriy Kirichok
    Howard Hughes Medical Institute, Department of Cardiovascular Research, Children s Hospital, andHarvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:360-4. 2004
    ..The channel is inwardly rectifying, making it especially effective for Ca2+ uptake into energized mitochondria. Thus, we conclude that the properties of the current mediated by this novel channel are those of the MCU...
  16. pmc Inositol trisphosphate receptor Ca2+ release channels
    J Kevin Foskett
    Department of Physiology, University of Pennsylvania, Philadelphia 19104 6085, USA
    Physiol Rev 87:593-658. 2007
    ..Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R...
  17. pmc STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
    Chan Young Park
    Department of Neurobiology, Stanford University School of Medicine, CA 94305, USA
    Cell 136:876-90. 2009
    ..These studies establish a molecular mechanism for store-operated Ca(2+) entry in which the direct binding of STIM1 to Orai1 drives the accumulation and the activation of CRAC channels at ER-PM junctions...
  18. pmc Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family
    Shu Hua Cheng
    Department of Genetics, Harvard Medical School, MA 02114, USA
    Plant Physiol 129:469-85. 2002
    ..By combining emerging cellular and genomic technologies with genetic and biochemical approaches, the characterization of Arabidopsis CDPKs provides a valuable opportunity to understand the plant calcium-signaling network...
  19. pmc The functional network of ion channels in T lymphocytes
    Michael D Cahalan
    Department of Physiology and Biophysics, and the Institute for Immunology, University of California, Irvine, Irvine, CA 92697 4561, USA
    Immunol Rev 231:59-87. 2009
    ....
  20. pmc Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
    Robert D Burgoyne
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, UK
    Nat Rev Neurosci 8:182-93. 2007
    ..The differing properties of these proteins allow them to have discrete, non-redundant functions...
  21. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
    ..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
  22. pmc MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
    Fabiana Perocchi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 467:291-6. 2010
    ..Its discovery may lead to the complete molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies for understanding their contribution to normal physiology and disease...
  23. pmc Calcium signals: the lead currency of plant information processing
    Jorg Kudla
    Institut fur Botanik, Universitat Munster, 48149 Munster, Germany
    Plant Cell 22:541-63. 2010
    ....
  24. pmc Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses
    Andrew F Macaskill
    Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuron 61:541-55. 2009
    ..Thus, Miro1 is a key determinant of how energy supply is matched to energy usage in neurons...
  25. ncbi The mystery and magic of glia: a perspective on their roles in health and disease
    Ben A Barres
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 60:430-40. 2008
    ..I argue that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly...
  26. pmc The CatSper channel: a polymodal chemosensor in human sperm
    Christoph Brenker
    Center of Advanced European Studies and Research caesar, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO J 31:1654-65. 2012
    ..We propose that the CatSper channel complex serves as a polymodal sensor for multiple chemical cues that assist sperm during their voyage across the female genital tract...
  27. pmc NAADP mobilizes calcium from acidic organelles through two-pore channels
    Peter J Calcraft
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
    Nature 459:596-600. 2009
    ..TPCs therefore provide new insights into the regulation and organization of Ca(2+) signals in animal cells, and will advance our understanding of the physiological role of NAADP...
  28. ncbi Calcineurin: form and function
    F Rusnak
    Section of Hematology Research and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Physiol Rev 80:1483-521. 2000
    ..This review provides a comprehensive examination of the biological roles of calcineurin and reviews aspects related to its structure and catalytic mechanism...
  29. ncbi NMDA receptor subunits: diversity, development and disease
    S Cull-Candy
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:327-35. 2001
    ..Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions...
  30. ncbi Progesterone activates the principal Ca2+ channel of human sperm
    Polina V Lishko
    Department of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, California 94158, USA
    Nature 471:387-91. 2011
    ....
  31. ncbi BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
    Luca Scorrano
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Department of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Science 300:135-9. 2003
    ..Thus, BAX and BAK operate in both the ER and mitochondria as an essential gateway for selected apoptotic signals...
  32. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
    ..Therefore, because astrocytes discriminate and integrate synaptic information, we propose that they can be considered as cellular elements involved in the information processing by the nervous system...
  33. ncbi Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    Christine Mummery
    Hubrecht Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 107:2733-40. 2003
    ..Here, we induced cardiomyocyte differentiation of hES cells by a novel method and compared their electrophysiological properties and coupling with those of primary human fetal cardiomyocytes...
  34. pmc Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria
    Cesar Cardenas
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 142:270-83. 2010
    ..Thus, constitutive InsP(3)R Ca(2+) release to mitochondria is an essential cellular process that is required for efficient mitochondrial respiration and maintenance of normal cell bioenergetics...
  35. ncbi The language of calcium signaling
    Antony N Dodd
    Department of Biology, University of York, York, United Kingdom
    Annu Rev Plant Biol 61:593-620. 2010
    ....
  36. pmc Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network
    Baoshan Xu
    Department of Biochemistry and Molecular Biology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e19052. 2011
    ..The results suggest that regulation of Cd-disrupted [Ca²+](i) homeostasis may be a new strategy for prevention of Cd-induced neurodegenerative diseases...
  37. ncbi Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    ..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
  38. pmc Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth
    Ahmed Hasbi
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 106:21377-82. 2009
    ..This dopaminergic pathway regulating neuronal growth and maturation through BDNF may have considerable significance in disorders such as drug addiction, schizophrenia, and depression...
  39. ncbi Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling
    Cendra Agulhon
    Department of Pharmacology, University of North Carolina at Chapel Hill, Genetic Medicine Building, CB 7365, Chapel Hill, NC 27599, USA
    Science 327:1250-4. 2010
    ..Our findings suggest that, at least in the hippocampus, the mechanisms of gliotransmission need to be reconsidered...
  40. ncbi Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2
    Maria Høyer-Hansen
    Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, 2100 Copenhagen, Denmark
    Mol Cell 25:193-205. 2007
    ..Thus, an increase in the [Ca(2+)](c) serves as a potent inducer of macroautophagy and as a target for the antiautophagy action of ER-located Bcl-2...
  41. ncbi The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
    Timo Strünker
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Nature 471:382-6. 2011
    ..The identification of CatSper channel blockers will greatly facilitate the study of Ca(2+) signalling in sperm and help to define further the physiological role of progesterone and CatSper...
  42. ncbi Bending the MDCK cell primary cilium increases intracellular calcium
    H A Praetorius
    NIH, NHLBI, LKEM, 10 Center Drive, Bldg 10, Bethesda, MD 20892 1603, USA
    J Membr Biol 184:71-9. 2001
    ..We conclude that the primary cilium in MDCK cells is mechanically sensitive and responds to flow by greatly increasing intracellular calcium...
  43. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
    ..This persistent plasticity was mGluR-mediated but N-methyl-d-aspartate receptor-independent. These results indicate that astrocytes are actively involved in the transfer and storage of synaptic information...
  44. ncbi Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo
    Norio Takata
    Laboratory for Neuron Glia Circuit and Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 31:18155-65. 2011
    ..Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex...
  45. pmc Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
    Eugen Brailoiu
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Cell Biol 186:201-9. 2009
    ..Thus, TPC1 is critical for NAADP action and is likely the long sought after target channel for NAADP...
  46. pmc Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
    Patrick G Hogan
    Department of Pathology, Harvard Medical School, Immune Disease Institute, Children s Hospital Boston, Massachusetts 02115, USA
    Annu Rev Immunol 28:491-533. 2010
    ..In this review, we discuss selected aspects of Ca(2+) signaling in cells of the immune system, focusing on the roles of STIM and ORAI proteins in store-operated Ca(2+) entry...
  47. ncbi Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    Micaela Zonta
    Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Nat Neurosci 6:43-50. 2003
    ..Taken together, our findings show that neuron-to-astrocyte signaling is a key mechanism in functional hyperemia...
  48. ncbi The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector
    Robert A Screaton
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 119:61-74. 2004
    ..Our results illustrate how a phosphatase/kinase module connects two signaling pathways in response to nutrient and hormonal cues...
  49. pmc CML42-mediated calcium signaling coordinates responses to Spodoptera herbivory and abiotic stresses in Arabidopsis
    Jyothilakshmi Vadassery
    Departments of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany
    Plant Physiol 159:1159-75. 2012
    ..Under drought stress, the level of abscisic acid accumulation was higher in cml42 plants. Thus, CML42 might serve as a Ca²⁺ sensor having multiple functions in insect herbivory defense and abiotic stress responses...
  50. ncbi Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors
    Tommaso Fellin
    Istituto CNR di Neuroscienze, Universita di Padova, Viale G Colombo 3, 35121, Italy
    Neuron 43:729-43. 2004
    ..Our results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors...
  51. pmc Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
    KISHORE V KUCHIBHOTLA
    Massachusetts General Hospital, Department of Neurology Alzheimer s Disease Research Laboratory, 114 16th Street, Charlestown, MA 02129, USA
    Science 323:1211-5. 2009
    ..Thus, although neurotoxicity is observed near amyloid-beta deposits, there exists a more general astrocyte-based network response to focal pathology...
  52. pmc Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways
    Markus Waldeck-Weiermair
    Institute of Molecular Biology and Biochemistry, Molecular and Cellular Physiology Research Unit, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 III, 8010 Graz, Austria
    J Biol Chem 286:28444-55. 2011
    ..Our data indicate that Letm1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca(2+) uptake pathways in intact endothelial cells...
  53. ncbi Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex
    James Schummers
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 320:1638-43. 2008
    ..Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses...
  54. ncbi Decoding cytosolic Ca2+ oscillations
    Anant B Parekh
    Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Trends Biochem Sci 36:78-87. 2011
    ....
  55. pmc Calcium signalling: fishing out molecules of mitochondrial calcium transport
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Biol 20:R888-91. 2010
    ..Now, RNAi studies link three proteins - MICU1, NCLX and LETM1 - to the previously unknown molecular mechanism of mitochondrial calcium transport...
  56. ncbi Wnt and calcium signaling: beta-catenin-independent pathways
    Aimee D Kohn
    Howard Hughes Medical Institute, Division of Hematology, Department of Pharmacology, and the Center for Developmental Biology, University of Washington School of Medicine, Box 357750, Seattle, WA 98195, USA
    Cell Calcium 38:439-46. 2005
    ..This review will focus on the role of calcium in Wnt signaling and, as a consequence, provide a limited overview of beta-catenin-independent Wnt signaling...
  57. pmc MAM: more than just a housekeeper
    Teruo Hayashi
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA
    Trends Cell Biol 19:81-8. 2009
    ..The MAM thus integrates signal transduction with metabolic pathways to regulate the communication and functional interactions between the ER and mitochondrion...
  58. ncbi Signaling at the gliovascular interface
    Marie Simard
    Department of Neurosurgery, New York Medical College, Valhalla, New York 10590, USA
    J Neurosci 23:9254-62. 2003
    Advances in fluorescent calcium indicating dyes over the past decade have identified calcium signaling as the tool by which astrocytes communicate among themselves and with neighboring neurons...
  59. pmc Store-independent activation of Orai1 by SPCA2 in mammary tumors
    Mingye Feng
    Department of Physiology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 143:84-98. 2010
    ..Our findings reveal a signaling pathway in which the Orai1-SPCA2 complex elicits constitutive store-independent Ca(2+) signaling that promotes tumorigenesis...
  60. pmc Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendrites
    Jun Noguchi
    Department of Cell Physiology, National Institute for Physiological Sciences and Graduate University of Advanced Studies SOKENDAI, Myodaiji, Okazaki 444 8787, Japan
    Neuron 46:609-22. 2005
    ..Spine-neck geometry is thus an important determinant of spine Ca2+ signaling, allowing small spines to be the preferential sites for isolated induction of long-term potentiation...
  61. ncbi The tripartite synapse: roles for gliotransmission in health and disease
    Michael M Halassa
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania, School of Medicine Philadelphia, PA 19104, USA
    Trends Mol Med 13:54-63. 2007
    ..The results of future experimental tests of the astrocyte activation spectrum, which relates gliotransmission to neurological and psychiatric disorders, might point to a new therapeutic target in the brain...
  62. ncbi Extracellular calcium sensing and extracellular calcium signaling
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Rev 81:239-297. 2001
    ..In any event, the CaR and other receptors/sensors for Ca(o)(2+) and probably for other extracellular ions represent versatile regulators of numerous cellular functions and may serve as important therapeutic targets...
  63. pmc Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit
    Muqing Yi
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 167:661-72. 2004
    ..Diminished mitochondrial motility in the region of the [Ca2+]c rise promotes recruitment of mitochondria to enhance local Ca2+ buffering and energy supply. This mechanism may provide a novel homeostatic circuit in calcium signaling.
  64. ncbi Calcium cycling and signaling in cardiac myocytes
    Donald M Bers
    Department of Physiology and Cardiovascular Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Annu Rev Physiol 70:23-49. 2008
    ..Importantly, although such diverse Ca-dependent regulations occur simultaneously in a cell, the cell can distinguish distinct signals by local Ca or protein complexes and differential Ca signal integration...
  65. ncbi The endoplasmic reticulum: a multifunctional signaling organelle
    Michael J Berridge
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB2 4AT, Babraham, UK
    Cell Calcium 32:235-49. 2002
    ..Conversely, the presenilins that appear to increase the Ca(2+) content of the ER lumen make cells more susceptible to apoptosis...
  66. pmc Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    Deepak A Deshpande
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1299-304. 2010
    ..Given the need for efficacious bronchodilators for treating obstructive lung diseases, this pathway can be exploited for therapy with the thousands of known synthetic and naturally occurring bitter tastants...
  67. ncbi Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
    Xiaohai Wang
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:816-23. 2006
    ..These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca(2+) occur independently of postsynaptic excitatory activity...
  68. ncbi Calcium, ischemia and excitotoxicity
    Kinga Szydlowska
    Toronto Western Hospital Research Institute, MC11 414, 399 Bathurst Street, Toronto, Ontario, Canada M5T2S8
    Cell Calcium 47:122-9. 2010
    ..However, identifying those that are most responsible for cell death and their downstream signalling pathways may lead to improved strategies for treating ischemic and excitotoxic disorders...
  69. pmc Calcium dynamics of cortical astrocytic networks in vivo
    Hajime Hirase
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA
    PLoS Biol 2:E96. 2004
    ..These findings indicate potential neuron-glia communication in the intact brain...
  70. pmc Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel
    Michael R Tadross
    Calcium Signals Laboratory, Departments of Biomedical Engineering and Neuroscience, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Cell 133:1228-40. 2008
    ..The emergence of complex decoding properties from the juxtaposition of common elements, and the techniques developed herein, promise generalization to numerous molecules residing near Ca(2+) sources...
  71. ncbi GLIA: listening and talking to the synapse
    P G Haydon
    Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA
    Nat Rev Neurosci 2:185-93. 2001
    ..Without such a view, it might be impossible to decode the language of the brain...
  72. ncbi Local Ca2+ detection and modulation of synaptic release by astrocytes
    Maria Amalia Di Castro
    Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    Nat Neurosci 14:1276-84. 2011
    ..These data provide direct evidence that astrocytes are integrated in local synaptic functioning in adult brain...
  73. ncbi Calcium gradients underlying cell migration
    Chaoliang Wei
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Life Sciences, The Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Curr Opin Cell Biol 24:254-61. 2012
    ..These recent findings provide a glimpse into how spatiotemporally coordinated calcium gradients orchestrate cellular behavior as complex as directional movement...
  74. pmc Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface
    György Csordás
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 39:121-32. 2010
    The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis...
  75. pmc Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain
    Manuela Simonetti
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg 69120, Germany
    Neuron 77:43-57. 2013
    ....
  76. pmc A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
    Edward G Lakatta
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 6825, USA
    Circ Res 106:659-73. 2010
    ..This review examines evidence that forms the basis of this coupled-clock system concept in cardiac SANCs...
  77. pmc Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm
    Wardah Alasmari
    From the Reproductive and Developmental Biology, Medical School, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 288:6248-58. 2013
    ....
  78. pmc General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex
    Alexander Stanley Thrane
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:18974-9. 2012
    b>Calcium signaling represents the principle pathway by which astrocytes respond to neuronal activity...
  79. pmc The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores
    Xiangang Zong
    Center for Integrated Protein Science CIPS M and Zentrum für Pharmaforschung, Department Pharmazie, Ludwig Maximilians Universitat Munchen, Butenandtstr 5 13, 81377, Munich, Germany
    Pflugers Arch 458:891-9. 2009
    ..By contrast, TPCN2-specific Ca(2+)-release is unaffected by emptying ER-based Ca(2+) stores. In conclusion, these findings indicate that TPCN2 is a major component of the long-sought lysosomal NAADP-dependent Ca(2+)-release channel...
  80. ncbi Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    Mustafa Naziroglu
    Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
    Neurochem Res 34:2181-91. 2009
    ..Blood GSH-Px activities could be a reliable indicator of selenium deficiency in patients with epilepsy...
  81. pmc Calcium signaling and amyloid toxicity in Alzheimer disease
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Biol Chem 285:12463-8. 2010
    ..Although no cause or cure is currently known, targeting Ca(2+) dyshomeostasis as an underlying and integral component of AD pathology may result in novel and effective treatments for AD...
  82. ncbi Directionally selective calcium signals in dendrites of starburst amacrine cells
    Thomas Euler
    Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 418:845-52. 2002
    ..This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells...
  83. ncbi Large-scale calcium waves traveling through astrocytic networks in vivo
    Nahoko Kuga
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 31:2607-14. 2011
    ..This novel phenomenon was heretofore overlooked, probably because of the high vulnerability of astrocytes to light damage; glissandi occurred only when observed at much lower laser intensities than previously used...
  84. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
    ..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
  85. pmc IP(3) receptors: toward understanding their activation
    Colin W Taylor
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, United Kingdom
    Cold Spring Harb Perspect Biol 2:a004010. 2010
    ....
  86. ncbi Inositol trisphosphate and calcium signalling mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochim Biophys Acta 1793:933-40. 2009
    ....
  87. ncbi Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
    Sean J Mulligan
    Brain Research Centre, Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
    Nature 431:195-9. 2004
    ..Vasoconstriction by astrocytes is a previously unknown mechanism for the regulation of CBF...
  88. ncbi Filopodial calcium transients promote substrate-dependent growth cone turning
    T M Gomez
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA
    Science 291:1983-7. 2001
    ..These rapid signals appear to serve both as autonomous regulators of filopodial movement and as frequency-coded signals integrated within the growth cone and could be a common signaling process for many motile cells...
  89. ncbi Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
    Peter B Stathopulos
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Cell 135:110-22. 2008
    ..We provide atomic resolution insight into the molecular basis for STIM1-mediated SOCE initiation and show that the folded/unfolded state of the Ca2+-sensing region of STIM is crucial to SOCE regulation...
  90. ncbi The synaptic vesicle cycle
    Thomas C Sudhof
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA Thomas
    Annu Rev Neurosci 27:509-47. 2004
    ..The present review attempts to relate these molecular data with physiological results in an emerging view of nerve terminals as macromolecular machines...
  91. pmc CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology
    Xiao Jian Han
    Department of Physiology and 2Department of Neuroscience, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Cell Biol 182:573-85. 2008
    ..CaMKIalpha is a widely expressed protein kinase, suggesting that Ca2+ is likely to be functionally important in the control of mitochondrial dynamics through regulation of Drp1 phosphorylation in neurons and other cell types...
  92. pmc TRPP2 and TRPV4 form a polymodal sensory channel complex
    Michael Köttgen
    Renal Division, University Hospital Freiburg, 79106 Freiburg, Germany
    J Cell Biol 182:437-47. 2008
    ..Because TRPV4-deficient zebrafish and mice lack renal cysts, our findings challenge the concept that defective ciliary flow sensing constitutes the fundamental mechanism of cystogenesis...
  93. ncbi Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
    H Llewelyn Roderick
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Nat Rev Cancer 8:361-75. 2008
    ..Here, we review the role of Ca2+ in promoting cell proliferation and cell death, how these processes are remodelled in cancer and the opportunities this might provide for therapeutic intervention...
  94. ncbi 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    FASEB J 16:1145-50. 2002
    ..These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling...
  95. ncbi Mitochondria: the hub of cellular Ca2+ signaling
    Gyorgy Szabadkai
    Department of Physiology, Mitochondrial Biology Group, University College London, London, United Kingdom
    Physiology (Bethesda) 23:84-94. 2008
    ..We here review the ways in which this system provides integrity and flexibility for the cell to cope with the countless demands throughout its life cycle and discuss briefly the mechanisms through which it can also drive cell death...
  96. ncbi Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
    Julia Foreman
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Nature 422:442-6. 2003
    ..This indicates that NADPH oxidases control development by making ROS that regulate plant cell expansion through the activation of Ca2+ channels...
  97. pmc Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo
    Kazuo Kitamura
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Neurosci 31:10847-58. 2011
    ....
  98. ncbi Ca(2+)/calmodulin regulates salicylic-acid-mediated plant immunity
    Liqun Du
    Center for Integrated Biotechnology and Department of Horticulture, Washington State University, Pullman, Washington 99164 6414, USA
    Nature 457:1154-8. 2009
    ..These results reveal a previously unknown regulatory mechanism linking Ca(2+) signalling to salicylic acid level...
  99. pmc Experience with moving visual stimuli drives the early development of cortical direction selectivity
    Ye Li
    Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Nature 456:952-6. 2008
    ..Both effects contributed to an increase in local coherence. We conclude that early experience with moving visual stimuli drives the rapid emergence of direction-selective responses in the visual cortex...
  100. pmc Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Cell Calcium 47:175-82. 2010
    ....
  101. ncbi Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
    H R Parri
    School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff, CF10 3US, Wales, UK
    Nat Neurosci 4:803-12. 2001
    ..These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system...

Research Grants70

  1. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..LPA and S1P regulate chemotaxis, stress responses, cytoskeletal organization, calcium signaling, cell survival, apoptosis, autophagy, and gene transcription...
  2. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..So-called "calcium signaling" is a universal language used by cells to react and change...
  3. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..To accomplish this goal, I have focused calcium signaling in heart function and development since undergraduate studies...
  4. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..To accomplish this goal, I have focused calcium signaling in heart function and development since undergraduate studies...
  5. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..or sarcoplasmic reticulum in cardiac myocytes) is a principal site for protein folding, calcium storage and calcium signaling. ER stress induced by accumulation of misfolded proteins and alterations in calcium homeostasis can trigger ..
  6. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
  7. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..sarcoplasmic reticulum calcium ATPase (SERCA) pump that resequesters calcium into the SER lumen following calcium signaling. The overall goal of this proposal is to show that ethanol-related increases in intracellular calcium levels ..
  8. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..PPG application entitled The role of astrocytes in ischemic stroke, and of my section therein, Astrocytic calcium signaling in the ischemic penumbra...
  9. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    ..This novel form of channel regulation may significantly impact L-type calcium channel activity, calcium signaling, and gene transcription in neurons...
  10. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..3 channels. We have developed highly specific inhibitors of Kv1.3 and these selectively suppress calcium signaling, cytokine production, proliferation, and in vivo migration of TEM cells without affecting other T cell ..
  11. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..Josiassen,R., Pribitkin,E.A., Lowry,L.D., Gallop,R.J., and Rawson,N.E. (2005). Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am. J. Psychiatry 162, 616-618. Rawson,N.E. (2000)...
  12. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..It is also expected that kisspeptin-induced Ca2+ mobilization will increase at puberty and that these changes will account for the pubertal increase in GnRH secretion. ..
  13. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2012
    ..Synapse and T cell anergy, 3) Sprouty 1 as a novel inhibitor of T cell activation, 4) Regulation of calcium signaling in T cells by TFII-I, 5) Regulation of NF-kB by TCR and costimulatory signaling...
  14. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2011
    ..b>Calcium signaling plays an important role in cell proliferation and apoptosis, yet little is known about regulation of ion ..
  15. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..The information resulting from these investigations has a potential to provide clues to how HCV-induced oxidative stress and calcium signaling may induce profibrogenic factor, TGF-21, liver fibrosis and ultimately liver cancer.
  16. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..production through two pathways: direct interaction with mitochondria! complex I and regulation of a calcium signaling pathway leading to the expression of PGC-1 alpha and uncoupling proteins...
  17. The Role of CRACM1 in the Pathogenesis of Systemic Lupus Erythematosus
    Peter C Chien; Fiscal Year: 2013
    ..Numerous studies have examined immunopathogenic mechanisms of lupus, including aberration in calcium signaling in activated T cells, which involves multiple molecular components...
  18. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ....
  19. Coordination of Pathophysiologic Endothelial Cell Signaling by ROS
    Madesh Muniswamy; Fiscal Year: 2012
    ..Understanding the mechanisms of superoxide-mediated calcium signaling and mitochondria-nuclear stress in endothelial cells are crucial to elucidating the fundamental role of ..
  20. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..We will explore how these and other molecularly-identified genes interact with each other, and with calcium signaling, to cause activation...
  21. The role of NFAT in podocyte damage and proteinuric kidney disease
    ALEXIS JOANNA SLOAN; Fiscal Year: 2013
    ..Aberrant calcium signaling has been implicated in many scenarios of kidney disease and glomerular damage...
  22. The role of intracellular trafficking pathways in calcium signaling
    Suzette Farber-Katz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Calcium signaling is essential for numerous biological processes...
  23. Hepatitis B virus X protein modulation of calcium signaling in HCC development
    JESSICA GARNER; Fiscal Year: 2013
    ..Our studies may also identify new therapeutic targets for blocking HBx activities and HBV replication and the development of HBV-associated HCC. ..
  24. Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity
    Robert Meller; Fiscal Year: 2012
    ..We will investigate the effect of preconditioning on NMDA receptor-mediated electrophysiological responses, calcium signaling, nitric oxide synthesis and cyclic AMP response element binding protein (CREB) phosphorylation...
  25. Role of Bone Morphogenetic Protein 4 in Hypoxic Pulmomary Hypertension
    Jian Wang; Fiscal Year: 2013
    ..Hypoxia, an important trigger of PH, has been found to enhance calcium signaling in pulmonary artery smooth muscle cells, causing cell proliferation and constriction...
  26. Calcium Signaling, Metabolism, and EC Coupling in Heart
    Joshua I Goldhaber; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The applicant's long-term aims are to continue studies on calcium signaling, excitation-contraction (EC) coupling, and the dependence of these processes on energy metabolism in cardiac muscle...
  27. Sox10 Alleles for Functional Analysis of Glial Lineages
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..b>Calcium signaling is a fundamental cellular mechanism by which cells transmit intracellular signals in response to extrinsic ..
  28. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..While much is now known about calcium signaling in astrocytes in normal brain, very little is understood about the mechanisms underlying intracellular ..
  29. Na,K-ATPase as an Integrator of the Calcium-signaling Machinery
    Zijian Xie; Fiscal Year: 2010
    ....
  30. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..using potentiometric and calcium-sensitive fluorescent dyes to reveal patterns of cardiac conduction and calcium signaling. With an integrated imaging system that can capture contraction mechanics, hemodynamics, calcium transients, ..
  31. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..2) GJA1 mutations alter gap junction intercellular communication of calcium signaling via mutant connexin 43 hemichannels...
  32. Development of a5* nAChR positive allosteric modulators for tobacco dependence
    JON MARTIN LINDSTROM; Fiscal Year: 2013
    ..as a primary screening strategy we will examine changes in agonist-induced increases of intracellular calcium signaling via membrane potential dyes and a fluorescent plate reader (FLIPR) in HEK cells stably expressing a5* nAChRs...
  33. The roles of primary cilia in cardiovascular system
    SURYA NAULI; Fiscal Year: 2012
    ..that PKD is associated with both genetic and functional defects in mechanosensory cilia, causing aberrant calcium signaling that lead to cardiovascular complications...
  34. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..Finally it is anticipated that the proposed experiments will lead to the identification of novel molecular targets for innovative therapeutic approaches for the treatment, prevention, and/or cure of this devastating seizure disorder. ..
  35. 3D Structure and Function of CRAC Channels
    STEPHEN BARSTOW LONG; Fiscal Year: 2013
    ..of CRAC channel function, thereby making significant contributions to multiple fields of research including calcium signaling, ion channels, and membrane protein structural biology...
  36. Novel Molecules in Calcium Signaling in Platelets
    Wolfgang Bergmeier; Fiscal Year: 2013
    ..An in-depth analysis of how CD-GEFI regulates platelet function in vitro and in vivo will aid in its establishment as a target for antiplatelet therapy. ..
  37. Targeting induction of calcium buffer proteins for treatment of viral encephaliti
    John D Morrey; Fiscal Year: 2013
    ..Because of expertise in neurovirology, antiviral research, vitamin D metabolism, and calcium signaling, we are uniquely positioned to discover therapy for viral encephalitis...
  38. Calcium Signaling in Pancreatic Beta Cell Endoplasmic Reticulum
    MICHAEL WILLIAM ROE; Fiscal Year: 2010
    ....
  39. Caveolae and mitochondria: A structural interface functionally linking calcium an
    GREGORY CHARLES AMBERG; Fiscal Year: 2013
    ..More specifically, this research investigates a novel regulatory mechanism where localized oxidant and calcium signaling microdomains functionally converge in arterial smooth muscle cells...
  40. Role of vitamin D and calcium signaling in wound healing
    DANIEL DAVID BIKLE; Fiscal Year: 2013
    ..Vitamin D and calcium signaling most likely play a role in these processes, although this has received little study in wound healing...
  41. Regulation of hair cell determination by the Wnt/Calcium signaling pathway
    Alain Dabdoub; Fiscal Year: 2012
    ..These studies will provide novel insights into cochlear development that might facilitate the advancement of strategies for the regeneration of mechanosensory hair cells that could potentially result in the improvement of hearing. ..
  42. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2011
    ..Both will be used to determine the effect on DBP-cell binding, calcium signaling, chemotaxis and shedding of the binding/signaling complex...
  43. Developing Neurons
    NICHOLAS CANADAY SPITZER; Fiscal Year: 2012
    ..It is expected that this work will contribute to understanding developmental disorders of the nervous system in which neurotransmitter expression is altered during embryonic and post-embryonic development. ..
  44. Presynaptic GABA-A receptor activation in auditory brainstem axon terminals
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2013
    ..Tools including fluorescent dyes that measure changes in calcium signaling (indicative of cellular activity) and 'optogenetic'tools that allow stimulation of individual ..
  45. Insulin Resistance and Myocardial Autophagy
    EVAN DALE ABEL; Fiscal Year: 2013
    ..for a role for intrinsic defects within cardiomyocytes that include altered mitochondrial function, altered calcium signaling and lipotoxicity...
  46. Intrinsic plasticity and information storage in cerebellar Purkinje cells
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2012
    ..we plan to examine the signaling cascades involved in the induction of excitability changes, including calcium signaling, phosphatases and kinases (including the use of mutant mice deficient in PKC, 1CaMKII and PP2B, respectively)..
  47. Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury
    Kalev Freeman; Fiscal Year: 2013
    ..data indicating TBI causes impaired endothelium-dependent vasodilation, despite elevations in endothelial calcium signaling. The hypothesis-driven research project will allow the applicant to develop skill in state-of-the art ..
  48. Genetics and Molecular Biology of Striated Muscle Myosin
    Sanford I Bernstein; Fiscal Year: 2013
    ..cardiomyopathy result in significant wall thickening, abnormal myofibrillar arrays, arrhythmias, disrupted calcium signaling, and transcript profiles that mimic the human condition, and that these pathologies can be suppressed by ..
  49. Molecular Mechanisms of Lifespan Extension by Dietary Restriction in Drosophila
    Pankaj Kapahi; Fiscal Year: 2013
    ..translation which included genes involved in mitochondrial functions, protein folding, fat metabolism and calcium signaling [1]...
  50. The Role of Calcium Signaling in Stem Cell Quiescence
    Gozde Yucel; Fiscal Year: 2010
    ..In order to further dissect the mechanism of calcium signaling and stem cell quiescence, I propose to dissect the molecular defects in of CaVI .2 mutant mice...
  51. Modulation of calcium signaling by changes in STIM expression
    Jonathan Soboloff; Fiscal Year: 2013
    ..Considered in combination, these investigations will provide the framework for a new understanding of how Ca2+ signals in cells are modulated over extended time periods via crosstalk between autocrine, paracrine and endocrine factors. ..
  52. Neuronal-Specific Splicing of CaV1.2 L-type Calcium Channels
    Kristin Webster; Fiscal Year: 2013
    ..I hypothesize that e1b is essential for facilitating intracellular calcium signaling through the MAPK pathway to induce activity-dependent gene expression...
  53. Function of Phospholipase Cgamma2 in RANKL-Induced Osteoclastogenesis
    Yabing Chen; Fiscal Year: 2010
    ..signals in RANKL-induced osteoclastogenesis provides insights into how RANKL signaling may activate calcium signaling. Costimulatory signals mediated by DNAX-activating protein 12 (DAP12) and Fc receptor common ? subunit (FcR?)..
  54. Regulation of Calcium Signaling in Retinal Ganglion Cells after Nerve Injury
    Nicholas C Brecha; Fiscal Year: 2013
    ..These studies are consistent with the health-related goals of the Veterans Adminstration to develop highly effective and novel treatments for eye injury and disease. ..
  55. Calcium Signaling and Ion Homeostasis Regulation
    Jian Kang Zhu; Fiscal Year: 2013
    ..Through a genetic screen and subsequent molecular and biochemical analysis, we discovered a calcium signaling pathway in which the calcium-binding protein SOS3 interacts with and activates the protein kinase SOS2, ..
  56. Ion Channel and Calcium Signaling in Ultraviolet Light Transduction in Human Skin
    Elena Oancea; Fiscal Year: 2013
    ..abstract_text> ..
  57. Hepatitis C Virus-Induced Liver Pathogenesis
    Aleem Siddiqui; Fiscal Year: 2013
    ..One of the consequences of the calcium signaling is the activation of calcium-dependent calpain proteases...
  58. Neurotrophin Protection in HIV and Aging
    Rick B Meeker; Fiscal Year: 2013
    ..Based on these observations, we hypothesize that neurotrophin and calcium signaling converge on mechanisms common to HIV and Alzheimer pathogenesis that regulate the actin cytoskeleton and ..
  59. MYCN-induced calcium and magnesium signaling regulates Neuroblastoma progression
    DANA LYNN TAKEKO KOOMOA; Fiscal Year: 2013
    ..The preliminary data indicate that MYCN initiates a change in calcium signaling, accompanied by a change in the transcriptional regulation of calcium channels, namely Orai1, Orai3 and ..
  60. Functional relevance of cardiac regeneration by c-kit positive stem cells
    JOHANNES VAN BERLO; Fiscal Year: 2013
    ..Jeffery Molkentin, a world renowned cardiac researcher who studies cardiac hypertrophy, calcium signaling and cell death using genetic mouse models...
  61. Functional relevance of cardiac regeneration by c-kit positive stem cells
    JOHANNES VAN BERLO; Fiscal Year: 2013
    ..Jeffery Molkentin, a world renowned cardiac researcher who studies cardiac hypertrophy, calcium signaling and cell death using genetic mouse models...
  62. Regulation of TRAIL Induced Apoptosis in Cancer Cells
    Gary Thomas; Fiscal Year: 2013
    ..becomes dephosphorylated, promoting mitochondria permeabilization and cell death by coordinating apoptotic calcium signaling with lysosome-mitochondria communication that mediates Bid activation...
  63. CYCLIC ADP RIBOSE METABOLISM IN OXIDATIVE CELL DEATH
    MYRON JACOBSON; Fiscal Year: 2002
    ..b>Calcium signaling is involved in pathways leading to oxidant induced cell death...
  64. Calcium Signaling in Developing Intestinal Epithelium
    Mrinalini Rao; Fiscal Year: 2005
    ....
  65. The effects of alcohol on cerebellar synaotic transmission and plasticity
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2010
    ....
  66. Muscle: Excitation/Contraction Coupling Gordon Research Conference
    Paul D Allen; Fiscal Year: 2011
    ..The 2012 conference will be held in Europe at the GRC site in Les Diablerets, Switzerland. Calcium signaling figures importantly in the adaptive responses of healthy muscle to exercise and age mutations in a number ..
  67. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    ..Our main hypothesis is that anoxia/hypoxia differentially alters calcium signaling in right versus left ventricles...
  68. Nicotinic Receptors in Glia-Neuron Interactions
    Sukumar Vijayaraghavan; Fiscal Year: 2009
    ..Calcium imaging will be used to elucidate the details of calcium signaling in these cells, including the contributions from various sources of calcium within astrocytes...
  69. Regulation of Myofibrillogenesis by Calcium Signaling
    Michael Ferrari; Fiscal Year: 2004
    ..Lastly, calcium dynamics and MFG will be simultaneously monitored in the living embryo at high resolution using far-red calcium indicators and sarcomeric GFP fusions, respectively. ..
  70. Calcium Signaling in Astrocytes
    KAREN S contact WILCOX; Fiscal Year: 2010
    ..A likely outcome of the proposed work will be entirely new ways to assess potential pharmacological therapies for epilepsy. ..