brain chemistry

Summary

Top Publications

  1. ncbi Extracellular N-acetylaspartate depletion in traumatic brain injury
    Antonio Belli
    Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
    J Neurochem 96:861-9. 2006
  2. ncbi Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
    G P Saborio
    Serono Pharmaceutical Research Institute, Geneva, Switzerland
    Nature 411:810-3. 2001
  3. pmc In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism
    Silvia Bernardi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Brain Res 1380:198-205. 2011
  4. ncbi Lipid rafts mediate the synaptic localization of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Programs in Biomedical Sciences, Cell Biology and Neuroscience, University of California San Francisco School of Medicine, San Francisco, California 94143 2140, USA
    J Neurosci 24:6715-23. 2004
  5. ncbi A general model of prion strains and their pathogenicity
    John Collinge
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK
    Science 318:930-6. 2007
  6. ncbi Quantitative MR imaging of brain iron: a postmortem validation study
    Christian Langkammer
    Department of Neurology and Division of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Radiology 257:455-62. 2010
  7. pmc Changes in glucose uptake rather than lactate shuttle take center stage in subserving neuroenergetics: evidence from mathematical modeling
    Mauro DiNuzzo
    Dipartimento di Fisica, Sapienza Universita di Roma, Rome, Italy
    J Cereb Blood Flow Metab 30:586-602. 2010
  8. pmc Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    Int J Nanomedicine 7:723-30. 2012
  9. ncbi Eight prion strains have PrP(Sc) molecules with different conformations
    J Safar
    Department of Neurology, University of California, San Francisco 94143 0518, USA
    Nat Med 4:1157-65. 1998
  10. ncbi The ketogenic diet changes metabolite levels in hippocampal extracellular fluid
    Ramakrishna Samala
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Neurochem Int 58:5-8. 2011

Detail Information

Publications309 found, 100 shown here

  1. ncbi Extracellular N-acetylaspartate depletion in traumatic brain injury
    Antonio Belli
    Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
    J Neurochem 96:861-9. 2006
    ..These results suggest that mitochondrial dysfunction is a significant contributor to poor outcome following TBI and propose extracellular NAA as a potential marker for monitoring interventions aimed at preserving mitochondrial function...
  2. ncbi Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
    G P Saborio
    Serono Pharmaceutical Research Institute, Geneva, Switzerland
    Nature 411:810-3. 2001
    ....
  3. pmc In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism
    Silvia Bernardi
    Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Brain Res 1380:198-205. 2011
    ..This study provides evidence of abnormalities in neurotransmission related to networks subserving executive control and alerting of attention, functions which have been previously implicated in ASD pathogenesis...
  4. ncbi Lipid rafts mediate the synaptic localization of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Programs in Biomedical Sciences, Cell Biology and Neuroscience, University of California San Francisco School of Medicine, San Francisco, California 94143 2140, USA
    J Neurosci 24:6715-23. 2004
    ....
  5. ncbi A general model of prion strains and their pathogenicity
    John Collinge
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK
    Science 318:930-6. 2007
    ..Recent advances suggest that prions themselves are not directly neurotoxic, but rather their propagation involves production of toxic species, which may be uncoupled from infectivity...
  6. ncbi Quantitative MR imaging of brain iron: a postmortem validation study
    Christian Langkammer
    Department of Neurology and Division of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
    Radiology 257:455-62. 2010
    ..To investigate the relationship between transverse relaxation rates R2 and R2*, the most frequently used surrogate markers for iron in brain tissue, and chemically determined iron concentrations...
  7. pmc Changes in glucose uptake rather than lactate shuttle take center stage in subserving neuroenergetics: evidence from mathematical modeling
    Mauro DiNuzzo
    Dipartimento di Fisica, Sapienza Universita di Roma, Rome, Italy
    J Cereb Blood Flow Metab 30:586-602. 2010
    ..Overall, our results suggest that the control of carbon recruitment for neurons and astrocytes is exerted at the level of glucose uptake rather than that of lactate shuttle...
  8. pmc Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    Int J Nanomedicine 7:723-30. 2012
    ....
  9. ncbi Eight prion strains have PrP(Sc) molecules with different conformations
    J Safar
    Department of Neurology, University of California, San Francisco 94143 0518, USA
    Nat Med 4:1157-65. 1998
    ....
  10. ncbi The ketogenic diet changes metabolite levels in hippocampal extracellular fluid
    Ramakrishna Samala
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Neurochem Int 58:5-8. 2011
    ..This work will now enable other researchers to mimic the hippocampal extracellular environment in experiments aimed at deciphering the mechanisms of the KD...
  11. pmc Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression
    Marcus A Lawson
    Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:1569-75. 2011
    ..The results reveal a potential role for Tat in the development of comorbid depression in HIV-infected individuals...
  12. pmc Darwinian evolution of prions in cell culture
    Jiali Li
    Department of Infectology, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA
    Science 327:869-72. 2010
    ..Prions, albeit devoid of a nucleic acid genome, are thus subject to mutation and selective amplification...
  13. ncbi Immunohistochemical localization of three different prepro-GnRHs in the brain and pituitary of the European sea bass (Dicentrarchus labrax) using antibodies to the corresponding GnRH-associated peptides
    David González-Martínez
    Departamento de Biologia, Facultad de Ciencias del Mar y Ambientales, Universidad de Cadiz, 11510 Puerto Real, Spain
    J Comp Neurol 446:95-113. 2002
    ....
  14. pmc Generating a prion with bacterially expressed recombinant prion protein
    Fei Wang
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43210, USA
    Science 327:1132-5. 2010
    ..Thus, as postulated by the prion hypothesis, the infectivity in mammalian prion disease results from an altered conformation of PrP...
  15. ncbi The GnRH system in the European sea bass (Dicentrarchus labrax)
    N Zmora
    National Center for Mariculture, Israel Oceanographic and Limnological Research, PO Box 1212, Eilat 88112, Israel
    J Endocrinol 172:105-16. 2002
    ..These new tools will be extremely useful to study further the development, regulation and functional significance of three independent GnRH systems in the brain of vertebrate species...
  16. ncbi Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility
    Naruhiko Sahara
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neurochem 83:1498-508. 2002
    ..The results suggest that tau in S2 represents an intermediate from which insoluble tau is derived, and that phosphorylation may play a role in filament formation and/or stabilization...
  17. ncbi Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
    R E Grahn
    Department of Psychology, Behavioral Neuroscience Program, University of Colorado, Boulder, CO 80309, USA
    Brain Res 826:35-43. 1999
    ..Inescapable tailshock led to greater serotonergic neural activity than did escapable tailshock, supporting the hypothesis that uncontrollable stressors preferentially activate serotonergic neurons in the DRN...
  18. pmc Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange
    Vytautas Smirnovas
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    Nat Struct Mol Biol 18:504-6. 2011
    ....
  19. ncbi Cerebral microdialysis: research technique or clinical tool
    M M Tisdall
    Department of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery Queen Square, London WC1N 3BG, UK
    Br J Anaesth 97:18-25. 2006
    ..Microdialysis has the potential to become an established part of mainstream multi-modality monitoring during the management of acute brain injury but at present should be considered a research tool for use in specialist centres...
  20. ncbi Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection
    Weibo Luo
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Brain Res Rev 56:331-45. 2007
    ..Here, we review the abnormal expression of PARs in the brain under pathological conditions, the functions of PARs in neurodegenerative disorders, and the molecular mechanisms involved...
  21. pmc Susceptibility contrast in high field MRI of human brain as a function of tissue iron content
    Bing Yao
    Advanced MRI Section, Laboratory of Functional Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1065, USA
    Neuroimage 44:1259-66. 2009
    ..The absence of saturation effects opens the way to exploit the benefits of MRI at high field strengths for the detection of iron distributions with high sensitivity and resolution...
  22. ncbi p145, a major Grb2-binding protein in brain, is co-localized with dynamin in nerve terminals where it undergoes activity-dependent dephosphorylation
    P S McPherson
    Department of Cell Biology, Howard Hughes Medical Research Institute, Yale University School of Medicine, New Haven, Connecticut 06510
    J Biol Chem 269:30132-9. 1994
    ..These findings suggest that p145 participates with dynamin in synaptic vesicle endocytosis and recycling...
  23. ncbi Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
    D R Borchelt
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 17:1005-13. 1996
    ..These studies provide compelling support for the view that one mechanism by which these mutant PS1 cause AD is by increasing the extracellular concentration of Abeta peptides terminating at 42(43), species that foster Abeta deposition...
  24. ncbi Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    Sabine Chourbaji
    Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
    Brain Res Mol Brain Res 121:28-36. 2004
    ..Thus, a chronic reduction of BDNF protein content in adult mice is not sufficient to induce neurochemical or behavioral alterations that are reminiscent of depressive symptoms in humans...
  25. pmc DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects
    Sylvia E Perez
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurosci Res 88:1026-40. 2010
    ..Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in reducing brain insults in female AD patients...
  26. pmc Alarin stimulates food intake in male rats and LH secretion in castrated male rats
    Nicole Van Der Kolk
    Department of Biology, Hope College, Holland, MI 49423, USA
    Neuropeptides 44:333-40. 2010
    ..Our studies demonstrate that alarin, like other members of the galanin family, is a neuromediator of food intake and body weight...
  27. ncbi Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent
    H V L N Swamy
    Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada
    J Anim Sci 80:3257-67. 2002
    ....
  28. ncbi A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
    G F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 848:141-52. 1999
    ....
  29. ncbi Human BACE forms dimers and colocalizes with APP
    Ariane Schmechel
    Freie Universitaet Berlin, Institut fuer Chemie Biochemie, Thielallee 63, Berlin D 14195, Germany
    J Biol Chem 279:39710-7. 2004
    ..Thus, homodimerization of BACE may help the enzyme to acquire specific mechanisms to associate with its substrates to exert catalytic activity...
  30. pmc Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating
    K Walther
    Zentrum Biochemie und Molekulare Zellbiologie, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    EMBO Rep 2:634-40. 2001
    ..We hypothesize that hStnB regulates synaptic vesicle recycling by facilitating vesicle uncoating...
  31. ncbi Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci Res 85:1834-50. 2007
    ....
  32. ncbi Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, California, USA
    Eur J Neurosci 22:617-26. 2005
    ..The marked effect of dietary n-3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk...
  33. ncbi Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
    Salit Tzaban
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, and Hadassah University Hospital, Jerusalem 91120, Israel
    Biochemistry 41:12868-75. 2002
    ..Whether these new PrP(Sc) species play a role in the biogenesis or the pathogenesis of prions remains to be established...
  34. pmc Natural and synthetic prion structure from X-ray fiber diffraction
    Holger Wille
    Institute for Neurodegenerative Diseases, Departments of Neurology and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16990-5. 2009
    ....
  35. pmc Genetic influence on the structural variations of the abnormal prion protein
    P Parchi
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 97:10168-72. 2000
    ....
  36. ncbi Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease
    S Rutger Leliveld
    Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    J Neurosci 28:3839-45. 2008
    ..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
  37. ncbi The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresis
    Daniel Martins-de-Souza
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, 13083 970 Campinas, SP, Brazil
    Brief Funct Genomic Proteomic 6:70-5. 2007
    ..Our results confirm that the most efficient solubilizing solution for 2-DE analysis of cytosolic and membrane Human Brain Proteins is SB combined with 4% CHAPS and 2% ASB-14...
  38. ncbi A vector for expressing foreign genes in the brains and hearts of transgenic mice
    D R Borchelt
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Genet Anal 13:159-63. 1996
    ..The MoPrP.Xho vector should be very useful in strategies designed to overexpress a variety of wild-type and disease related mutant transgenes in the heart and brain...
  39. pmc Susceptibility induced gray-white matter MRI contrast in the human brain
    Christian Langkammer
    Department of Neurology, Medical University of Graz, Austria
    Neuroimage 59:1413-9. 2012
    ..Both, myelin and iron impact the effective transverse relaxation rate R2 significantly. Magnitude contrast is limited because it only reflects the extent but not the direction of the susceptibility shift...
  40. ncbi Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
    V Brown
    Howard Hughes Medical Institute, Department of Human Genetics, Department of Pediatrics, Atlanta, GA 30322, USA
    Cell 107:477-87. 2001
    ..We conclude that translational dysregulation of mRNAs normally associated with FMRP may be the proximal cause of fragile X syndrome, and we identify candidate genes relevant to this phenotype...
  41. ncbi Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
    A J Nimmo
    School of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD, Australia
    Neuropeptides 38:40-7. 2004
    ....
  42. ncbi Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 8:19-29. 2003
    ....
  43. ncbi Whole-brain susceptibility mapping at high field: a comparison of multiple- and single-orientation methods
    Sam Wharton
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
    Neuroimage 53:515-25. 2010
    ....
  44. ncbi Estimation of brain iron concentration in vivo using a linear relationship between regional iron and apparent transverse relaxation rate of the tissue water at 4.7T
    Fumiyuki Mitsumori
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Magn Reson Med 62:1326-30. 2009
    ..When accounting for f(M) in the analysis, the apparent transverse relaxation rate seems to give a significantly better estimation of regional [Fe]...
  45. pmc Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria
    Fiona E Lovegrove
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5G 2C4
    Am J Pathol 171:1894-903. 2007
    ....
  46. ncbi Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy
    Ivan Tkac
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 50:24-32. 2003
    ..The current data may serve as a reference for studies focused on developmental defects and pathologies using neonatal rat models...
  47. pmc Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry
    Ann M Knolhoff
    Department of Chemistry and the Beckman Institute, University of Illinois, Urbana, Illinois 61801, United States
    Anal Chem 85:3136-43. 2013
    ..Because the CE-MS and expression profiling are both amenable to small-volume analysis, this integrated analysis is applicable to a range of volume-limited biological systems...
  48. ncbi Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats
    Jared Clarke
    Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Eur J Neurosci 26:1845-52. 2007
    ..The present data suggest that while overexpression of APP in rats may provide some histological neuroprotection in the event of cerebral ischaemia, this does not translate into significant functional recovery...
  49. pmc On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field
    Jongho Lee
    Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 49:193-8. 2010
    ..This result suggests that endogenous deoxy-hemoglobin has no significant contribution to phase contrast between gray and white matter...
  50. pmc Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings
    Wei Li
    Brain Imaging and Analysis Center, Department of Biomedical Engineering, School of Medicine, Duke University, Durham, NC 27705, USA
    Neuroimage 59:2088-97. 2012
    ....
  51. pmc Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location
    Ivan Timofeev
    Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 28:849-60. 2011
    ..Decreases in perfusion and oxygenation were associated with deteriorating neurochemistry and these effects were more pronounced in perilesional tissue and when cerebrovascular reactivity was impaired...
  52. pmc MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping
    Berkin Bilgic
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroimage 59:2625-35. 2012
    ....
  53. ncbi Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
    R J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Nutr Health Aging 13:189-97. 2009
    ..A treatment that increased the formation of neurites and dendritic spines might reverse this loss, thereby increasing the number of synapses and slowing the decline in cognition...
  54. ncbi Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry
    Ioana M Taban
    FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    J Am Soc Mass Spectrom 18:145-51. 2007
    ..To reduce the extended measuring times involved, it is recommended to restrict the FTICR-MS analyses to areas of interest as can be preselected by other, faster imaging methods...
  55. ncbi Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
    Marco Giorgetti
    Medivation, Inc, San Francisco, California 94105, USA
    J Pharmacol Exp Ther 333:748-57. 2010
    ..The cognition-enhancing effects of Dimebon are unlikely to be mediated by AChE inhibition or NMDA receptor antagonism, and its mechanism of action appears to be distinct from currently approved medications for AD...
  56. ncbi Clinical cerebral microdialysis: a methodological study
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 93:37-43. 2000
    ....
  57. pmc ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein
    Jennifer Westling
    Center for Research in Paediatric Orthopaedics, Shriners Hospital, Tampa, FL 33612, U S A
    Biochem J 377:787-95. 2004
    ....
  58. pmc Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
    Suzanne E Wahrle
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 118:671-82. 2008
    ..These data support the conclusions that increased ABCA1-mediated lipidation of apoE in the CNS can reduce amyloid burden and that increasing ABCA1 function may have a therapeutic effect on AD...
  59. ncbi Dopamine covalently modifies and functionally inactivates parkin
    Matthew J LaVoie
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 7th Floor, Boston, Massachusetts 02115, USA
    Nat Med 11:1214-21. 2005
    ....
  60. ncbi Immunolocalization of CCK1R in rat brain using a new anti-peptide antibody
    Linda D Mercer
    Department of Pharmacology, Monash University, Clayton, VIC 3800, Australia
    Neurosci Lett 359:109-13. 2004
    ..The widespread distribution of CCK1R has implications for the functional roles of these receptors in brain. The high titre and low background seen with this new antiserum makes it of great value for cell and tissue research...
  61. ncbi Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study
    Chuck T Chen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building, 150 College St, Room 306, Toronto, Ontario, Canada M5S 3E2
    Prostaglandins Leukot Essent Fatty Acids 80:157-63. 2009
    ..These findings suggest that low levels of EPA in brain phospholipids compared to DHA may be the result of its rapid beta-oxidation upon uptake by the brain...
  62. ncbi Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat
    B Topic
    Institute of Physiological Psychology, Heinrich Heine University of Dusseldorf, Universitatsstr 1, D 40225, Dusseldorf, Germany
    Neurobiol Aging 23:135-43. 2002
    ....
  63. ncbi Characterization and distribution of angiotensin II receptor subtypes in the mouse brain
    W Hauser
    Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892 1514, USA
    Eur J Pharmacol 348:101-14. 1998
    ..Our data also form the basis for future studies of mouse models such as those with angiotensin receptor gene deficiencies...
  64. ncbi Cytokine signals propagate through the brain
    L Vitkovic
    CNRS INSERM Centre de Pharmacologie Endocrinologie, Montpellier, France
    Mol Psychiatry 5:604-15. 2000
    ..This elucidation is a prerequisite for better understanding of reciprocal interactions between nervous, endocrine and immune systems...
  65. ncbi Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice
    T Deltheil
    Laboratoire de Neuropharmacologie, Universite Paris Sud, EA 3544, Faculte de Pharmacie, 5, rue J B Clement, Tour D1, 2e etage, Chatenay Malabry Cedex F 92296, France
    Neuropharmacology 55:1006-14. 2008
    ..In view of developing new antidepressant drug strategy, a poly-therapy combining BDNF with a chronic SSRI treatment could thus improve the efficacy of current medications...
  66. ncbi A cellular gene encodes scrapie PrP 27-30 protein
    B Oesch
    Cell 40:735-46. 1985
    ..No PrP-related nucleic acids were found in purified preparations of scrapie prions, indicating that PrP 27-30 is not encoded by a nucleic acid carried within the infectious particles...
  67. ncbi The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
    K O Cho
    Division of Biology, California Institute of Technology, Pasadena 91125
    Neuron 9:929-42. 1992
    ..The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain...
  68. ncbi Brain spectrin: of mice and men
    S R Goodman
    Department of Structural and Cellular Biology, University of South Alabama College of Medicine, Mobile 36688, USA
    Brain Res Bull 36:593-606. 1995
    ..We finish with a discussion of the value of spectrin and ankyrin-deficient mouse models in deciphering spectrin function in neural tissue...
  69. ncbi Gray and white matter brain chemistry in young children with autism
    Seth D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
    Arch Gen Psychiatry 63:786-94. 2006
    ..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
  70. pmc Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner
    Yuri Kawasaki
    Department of Prion Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Virol 81:12889-98. 2007
    ..The mechanism of the prion strain-dependent effectiveness needs to be elucidated and managed. Nevertheless, the identification of an orally available amyloidophilic chemical encourages the pursuit of chemotherapy for prion diseases...
  71. pmc Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity
    Mekky M Abouzied
    Institut fur Physiologische Chemie, Rheinische Friedrich Wilhelms Universitat, Nussallee 11, 53115 Bonn, Germany
    Biochem J 378:169-76. 2004
    ..In addition, their simultaneous expression in the same cell and their different subcellular localization in cultured neurons suggest different functions of HDGF and HRP-3 within single cells...
  72. ncbi Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry
    A F Maarten Altelaar
    FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    Anal Chem 78:734-42. 2006
    ....
  73. ncbi Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice
    Hina Mehta
    Division of Neurosciences, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    Behav Brain Res 145:31-6. 2003
    ..Our present results support the earlier electrophysiological evidences that harmaline-induced tremor originates from ON, and confirm the role of 5-HT in the genesis of this motor neuronal dysfunction...
  74. ncbi Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase
    Y C Chang
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 8:2123-30. 1988
    ..GAD-6 does not recognize the 63 kDa band. In Western blots of unfractionated homogenates of the whole brain, the only band recognized by GAD-6 is a 59 kDa band.(ABSTRACT TRUNCATED AT 250 WORDS)..
  75. ncbi Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism
    Carl Henrik Nordstrom
    Department of Clinical Neuroscience, Lund University Hospital, Lund, Sweden
    Anesthesiology 98:809-14. 2003
    ....
  76. ncbi Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
    Kim N Green
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4545, USA
    J Neurosci 27:4385-95. 2007
    ..Collectively, these results suggest that DHA and DPAn-6 supplementations could be a beneficial natural therapy for AD...
  77. ncbi Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry
    Xianlin Han
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anal Biochem 302:199-212. 2002
    ....
  78. ncbi Stress and neuroactive steroids
    M L Barbaccia
    Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, Italy
    Int Rev Neurobiol 46:243-72. 2001
    ..This chapter summarizes observations from our laboratories and others, suggesting that neurosteroids and GABAergic transmission are important contributors to the changes in emotional state induced by environmental stress...
  79. ncbi 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  80. ncbi Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion
    C A Llewelyn
    National Blood Service, Cambridge Centre, Cambridge CB2 2PT, UK
    Lancet 363:417-21. 2004
    ..We aimed to identify whether vCJD is transmissible through blood transfusion...
  81. ncbi Glutathione pathways in the brain
    Ralf Dringen
    Physiologisch chemisches Institut der Universität Tübingen, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
    Biol Chem 384:505-16. 2003
    ..In addition, implications of disturbed GSH pathways in brain for neurodegenerative diseases will be discussed...
  82. pmc Supply and demand in cerebral energy metabolism: the role of nutrient transporters
    Ian A Simpson
    Department of Neural and Behavioral Sciences College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Cereb Blood Flow Metab 27:1766-91. 2007
    ....
  83. ncbi Sporadic and familial CJD: classification and characterisation
    Pierluigi Gambetti
    Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Br Med Bull 66:213-39. 2003
    ..The clinical and pathological features are summarised for each sporadic CJD subtype and familial CJD haplotype...
  84. ncbi The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
    B C Campbell
    Department of Pathology, The University of Melbourne, Victoria, Australia
    J Neurochem 76:87-96. 2001
    ..Highly insoluble alpha SN is not involved in the pathogenesis of MSA. It is therefore possible that buffered saline-soluble or detergent-soluble forms of alpha SN are involved in the pathogenesis of other alpha SN-related diseases...
  85. ncbi Automatic quantitation of localized in vivo 1H spectra with LCModel
    S W Provencher
    Max Planck Institute for Biophysical Chemistry, D 37070 Gottingen, Germany
    NMR Biomed 14:260-4. 2001
    ..LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS...
  86. ncbi GABAergic dysfunction in mood disorders
    P Brambilla
    Biological Psychiatry Unit, IRCCS S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Mol Psychiatry 8:721-37, 715. 2003
    ..In this paper, we discuss the status of GABAergic hypothesis of mood disorders and suggest possible directions for future preclinical and clinical research in this area...
  87. ncbi Synthetic mammalian prions
    Giuseppe Legname
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Science 305:673-6. 2004
    ..Neuropathological findings suggest that a novel prion strain was created. Our results provide compelling evidence that prions are infectious proteins...
  88. ncbi Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
    G M Pasinetti
    Neuroinflammation Research Center, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci Res 65:471-6. 2001
    ..The study suggests new means to dissect and classify stages of AD dementia, or neuropathology, at the molecular level...
  89. ncbi Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    K G Mountjoy
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201 3098
    Mol Endocrinol 8:1298-308. 1994
    ..The high degree of conservation, distinct pharmacology, and unique neuronal distribution of the MC4 receptor suggest specific and complex roles for the melanocortin peptides in neuroendocrine and autonomic control...
  90. pmc Serotonin and GABA are colocalized in restricted groups of neurons in the larval sea lamprey brain: insights into the early evolution of neurotransmitter colocalization in vertebrates
    Antón Barreiro-Iglesias
    Department of Cell Biology and Ecology, Faculty of Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    J Anat 215:435-43. 2009
    ..Cotransmission by release of 5-HT and GABA by the here-described lamprey brain neurons is proposed...
  91. ncbi Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning
    Eija Koponen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    Mol Cell Neurosci 26:166-81. 2004
    ..TK+ mice. Altogether, overexpression of the trkB.TK+ receptor postnatally leads to selective activation of trkB signaling pathways and enhanced learning and memory...
  92. ncbi Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
    A Soontornmalai
    University of Zurich, Institute of Pharmacology and Toxicology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Neuroscience 138:159-69. 2006
    ....
  93. pmc Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice
    Philipp Weyermann
    Santhera Pharmaceuticals Switzerland Ltd, Liestal, Switzerland
    PLoS ONE 4:e4774. 2009
    ..e. to increase food intake and to reduce energy expenditure...
  94. ncbi Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum
    L S Janis
    Department of Cell Biology and Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurosci 19:4962-71. 1999
    ..These observations implicate selective interactions between ephrin-A molecules and EphA RTKs as potential mechanisms for regulating the compartmental organization of the striatum...
  95. pmc microRNA modulation of circadian-clock period and entrainment
    Hai Ying M Cheng
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Neuron 54:813-29. 2007
    ..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment...
  96. ncbi Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse
    S Takeda
    Department of Clinical Gene Therapy, Osaka University, Yamadaoka, Osaka 565 0871, Japan
    Neuroscience 186:110-9. 2011
    ....
  97. ncbi Molecular taxonomy of major neuronal classes in the adult mouse forebrain
    Ken Sugino
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, MS 008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
    Nat Neurosci 9:99-107. 2006
    ..This dataset should be useful for the classification of unknown neuronal subtypes, the investigation of specifically expressed genes and the genetic manipulation of specific neuronal circuit elements...
  98. ncbi Influence of the normalization template on the outcome of statistical parametric mapping of PET scans
    J D Gispert
    Medical Imaging Laboratory, Hospital Universitario Gregorio Maranon, Madrid, Spain
    Neuroimage 19:601-12. 2003
    ..These results show that the use of the standard template under inappropriate conditions (different tracer or mental state) may lead to inconsistent interpretations of the statistical analysis...
  99. ncbi Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients
    Richard E Harris
    Assistant Professor, Research Specialist, Professor, Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan Assistant Professor, Research Fellow, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Senior Director, Director, Pfizer Incorporated, Groton, Connecticut Professor, Department of Radiology, Division of Neuroradiology, University of Michigan, and Department of Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden Assistant Professor, Department of Radiology, Division of Neuroradiology, University of Michigan, and Ann Arbor VA Healthcare System Assistant Professor, Department of Radiology, Division of Neuroradiology, University of Michigan Associate Professor, Department of Neurology, Bergmannsheil, Berufsgenossenschaftliche Universitätsklinik, Ruhr Universitat Bochum, Bochum, Germany
    Anesthesiology 119:1453-64. 2013
    ..However, human brain neuroimaging techniques enable the assessment of functional and neurochemical alterations in patients experiencing chronic pain and how these factors may dynamically change with pharmacologic treatment...
  100. ncbi Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS/MS: identification of ceramides containing sphingadienine
    Benoit Colsch
    Institut National de la Santé et de la Recherche Médicale U495, Laboratoire de Neurochimie, Hopital de la Salpetriere, 75651 Paris 13, France
    J Lipid Res 45:281-6. 2004
    ..Sphingadienine is present in galactosylceramide and sulfatides. Free ceramides contain the three types of bases. Thus, there could be two separate pools of free ceramides (d18:1, d18:2 and d20:1, d18:1) as precursors of complex SGL...
  101. pmc Phase contrast imaging in neonates
    Kai Zhong
    Department of Biomedical Magnetic Resonance, Faculty for Natural Sciences, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Haus 65, D 39120, Magdeburg, Germany
    Neuroimage 55:1068-72. 2011
    ..Therefore, magnetic resonance phase imaging is suggested as a novel tool to study neonatal brain development and pathologies in neonates...

Research Grants85

  1. CNS Plasticity of Human Adipo-derived Multipotent Cells
    Kevin Lee; Fiscal Year: 2004
    ..The results of these studies will provide the first evidence of hADC plasticity in the brain and could form the foundation for future cell-based therapies in the CNS. ..
  2. Sphingolipids in Ethanol-Induced Neuronal Apoptosis
    Mariko Saito; Fiscal Year: 2010
    ..These studies will reveal the functions of sphingolipids in ethanol-induced apoptosis in the developing brain, and will offer bases for future therapeutic strategies for FASD. ..
  3. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  4. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  6. Neurochemical Correlates of Pathology in Spinocerebellar Ataxias
    GULIN OZ; Fiscal Year: 2008
    ..Successful application of such treatments is expected to reduce the burden caused by these diseases on individuals, their families and society. [unreadable] [unreadable] [unreadable]..
  7. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  9. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  10. PET, APOE & The Preclinical Course of Alzheimer Disease
    Eric Reiman; Fiscal Year: 2006
    ..abstract_text> ..
  11. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  12. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  13. Fully Compensated Dynamic Shim System for In Vivo MRI and MRS
    ROBIN DE GRAAF; Fiscal Year: 2008
    ..Since MFI affects many facets of in vivo NMR, the successful implementation of DSU will have major impacts on almost all aspects of MRI and MRS and can thus be labeled as highly significant. [unreadable] [unreadable] [unreadable]..
  14. Human Brain Antioxidant Levels Measured In Vivo as a Function of Age and Diet
    Melissa Terpstra; Fiscal Year: 2008
    ..This work could lead to improved cognitive health of the aging American population. [unreadable] [unreadable] [unreadable]..
  15. The Role of Quinols in Estrogen Neuroprotection
    Laszlo Prokai; Fiscal Year: 2006
    ..Hence, they will serve as new lead compounds for the development of neuroprotective agents with improved efficacy. ..
  16. BRAIN TARGETING OF THYROTROPIN RELEASING HORMONE ANALOGS
    Laszlo Prokai; Fiscal Year: 2002
    ..Behavioral observations, dose-dependence and duration of action will also be addressed by appropriate method or study designs. ..
  17. TREATMENT FOR ALCHOLISM: A PRIMATE MODEL
    KELLY COSGROVE; Fiscal Year: 2002
    ..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
  18. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
  19. Novel Technologies for Global Optimization of Magnetic Field Homogeneity
    ROBIN DE GRAAF; Fiscal Year: 2007
    ..Since MFI affects many facet's of in vivo NMR, the proposed techniques will have major impacts on almost all aspects of MRI and MRS. ..
  20. Quantitative, Dynamic Functional 1H MRS of Human Brain
    ROBIN DE GRAAF; Fiscal Year: 2002
    ..A neurochemical basis of human brain mapping can provide valuable information about functional data comparisons between normal and diseased cerebral tissue. ..
  21. Cerebral Metabolic Flux Mapping Using Oxygen 17 NMR
    Robin A de Graaf; Fiscal Year: 2010
    ..7 t. ..
  22. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  23. THE ROLE OF SULFATIDES IN ALZHEIMER'S DISEASE
    Xianlin Han; Fiscal Year: 2008
    ..abstract_text> ..
  24. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  26. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  27. Quantitative, Dynamic Functional 1H MRS of Human Brain
    ROBIN DE GRAAF; Fiscal Year: 2005
    ..A neurochemical basis of human brain mapping can provide valuable information about functional data comparisons between normal and diseased cerebral tissue. ..
  28. Survey of Age-Associated Carbonylation of Brain Proteins
    Laszlo Prokai; Fiscal Year: 2008
    ..The degree of association will be determined between performance in each task and the degree of specific carbonylation associated with individual aging-associated oxidation-sensitive proteins. ..
  29. Pet Imaging of Extrastriatial Dopamine Levels
    Robert Kessler; Fiscal Year: 2005
    ..abstract_text> ..
  30. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  31. In vivo Substrate Utilization in the Newborn Rat Brain
    Raghavendra Rao; Fiscal Year: 2006
    ....
  32. Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study
    Ruth Salo; Fiscal Year: 2007
    ..These findings will have important implications for neurobiological models of comorbid substance abuse and treatment. [unreadable] [unreadable] [unreadable]..
  33. Alcohol and Tobacco CNS Effects in Binge Drinkers
    JOHN M POLICH; Fiscal Year: 2010
    ....
  34. Invivo imaging of mouse spinal cord axonal degeneration
    Jiangyang Zhang; Fiscal Year: 2007
    ..The results will then be correlated with ex vivo MR measurements and histopathology. [unreadable] [unreadable] [unreadable]..
  35. Estrogen-Induced Neuroprotective Mitochondrial Mechanism
    ROBERTA BRINTON; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  36. SPHINGOGLYCOLIPIDS OF NORMAL AND PATHOLOGICAL BRAINS
    Robert K Yu; Fiscal Year: 2010
    ..abstract_text> ..
  37. Opioid mediation of stress-potentiated cocaine response
    Charles Chavkin; Fiscal Year: 2007
    ..WCVC recordings from cell types will be made. The results should provide essential insight to the possible cellular and molecular mechanisms underlying the regulation of cocaine addiction by kappa opioid systems. ..
  38. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  39. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
  40. Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver Biology
    Susanne Keiding; Fiscal Year: 2010
    ..This will lead to improved diagnosis and treatment of the large groups of patients with liver disease and cancer in the liver. ..
  41. Antidepressants - same effect on mesolimbic DA activity?
    JAY WEISS; Fiscal Year: 2009
    ....
  42. Specific role of FGF8 and FGF17 in cortical patterning
    Jennifer Wilcoxon; Fiscal Year: 2007
    ..Findings should help identify interactions between telencephalic Fgf8 and some of the transcription factors implicated in area patterning. [unreadable] [unreadable]..
  43. Decision Making in Marijuana Users
    Linda Porrino; Fiscal Year: 2009
    ..Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ..
  44. PROTON MRS STUDIES IN GENERALIZED ANXIETY DISORDER
    Sanjay Mathew; Fiscal Year: 2008
    ..A specific long-term goal is for the candidate to develop sufficient expertise in MRS to sustain valid and creative application to problems of GAD and related conditions. ..
  45. Real-Time Functional MRI with Automated Pattern Classification
    Stefan Posse; Fiscal Year: 2008
    ..The long-term goal of this project is to develop an automated fMRI analysis tool that will have significant commercial potential for clinical and research use. [unreadable] [unreadable] [unreadable]..
  46. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  47. Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    DEEPAK D SOUZA; Fiscal Year: 2008
    ..These results may reflect indirect evidence of altered CB-1R function in FHP individuals. [unreadable] [unreadable] [unreadable]..
  48. SSRI-INDUCED CHANGES IN CORTICAL GABA IN WOMEN WITH PMDD
    CYNTHIA EPPERSON; Fiscal Year: 2007
    ..We anticipate that our findings will provide further support for the role of GABA and neurosteroids in the pathogenesis and treatment of PMDD. ..
  49. FUNCTIONAL METABOLISM IN WORKING BRAIN
    Gerald Dienel; Fiscal Year: 2007
    ..abstract_text> ..
  50. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006
    ..abstract_text> ..
  51. Piperidine Derivatives as Radiotracers for Serotonin Transporters
    Gilles Tamagnan; Fiscal Year: 2004
    ..abstract_text> ..
  52. Functional Relevance of Microglial Cannabinoid Receptors
    Guy Cabral; Fiscal Year: 2004
    ..Functional assays will employ paired cannabinoid enantiomers, receptor subtype-specific antagonists, and cannabinoids exhibiting differential ligand binding affinities to establish structure-activity relationships. ..
  53. Human Brain Metabolism in Ketosis
    Jullie Pan; Fiscal Year: 2004
    ..We anticipate that these data will contribute towards better understanding of themechanism of seizure control by theketogenic diet. ..
  54. OLFACTORY NEURONS: A MODEL FOR NEUROTROPHIN FUNCTION
    Gabriele Ronnett; Fiscal Year: 2004
    ..Understanding these mechanisms is essential to our ability to manipulate that process. ..
  55. ENDOGENOUS OPIOID PEPTIDE ACTION IN THE HIPPOCAMPUS
    Charles Chavkin; Fiscal Year: 2004
    ..Information obtained from this study will allow us to understand the events underlying an important type of opioid-induced, presynaptic inhibition of transmitter release. ..
  56. CEREBRAL GLUCOSE METABOLISM IN DOWN SYNDROME
    RICHARD HAIER; Fiscal Year: 2003
    ..These data will provide important information for the timing of treatment interventions and may aid in early detection of dementia and the classification of DS subtypes. ..
  57. Evaluation of Presynaptic Calcium Channels In Vivo
    Daniel Silverman; Fiscal Year: 2003
    ..A possible peripheral benefit of this work lies in its potential to bring us closer to an effective CNS delivery system for calcium channel antagonists which are under clinical development as therapeutic agents. ..
  58. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
  59. Role of Calcium in Cocaine-Induced Sensitization
    STEPHANIE LICATA; Fiscal Year: 2002
    ..Second, rats will receive either acute or repeated cocaine and relative abundance of either calmodulin or CaMKII will be measured in the VTA and substantia nigra using immunolabeling techniques. ..
  60. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..abstract_text> ..
  61. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    ..However, the optimal stimulation sites and paradigms muse be identified and proven effective, first, in control populations, and later, in pathological populations. ..
  62. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
    ..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..
  63. Role of GH deficiency on mitochondrial bioenergetics
    Holly Brown Borg; Fiscal Year: 2005
    ..Determining GH-dependent pathways and mechanisms may suggest potential therapeutic interventions to delay aging, treat aging-related disorders and extend life span in humans. ..
  64. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  65. DEVELOPMENT OF PET AND SPECT LIGANDS FOR mGluR5 IMAGING
    Gilles Tamagnan; Fiscal Year: 2007
    ..abstract_text> ..
  66. Olfactory neurons from bipolar patients
    Chang Gyu Hahn; Fiscal Year: 2006
    ..2) To identify therapeutically relevant changes in ICa homeostasis following lithium treatment. 3) To characterize ORN cultures from bipolar patients using odorant induced ICa responses. ..
  67. Confocal/Multiphoton Microscope
    Jeff Lichtman; Fiscal Year: 2004
    ..It will be available to other members of the Neuroscience community at Washington University, particularly for exploring and developing new optical imaging tools. ..
  68. Photoperiod, Melatonin, and Sickness Behaviors
    Randy Nelson; Fiscal Year: 2006
    ..6) To determine if photoperiod influences the extent to which stress compromises immune function. Taken together, these studies may reveal novel therapeutic uses of melatonin on fever and anorexia. ..
  69. MR Analysis of Persistent CNS Damage in Human MDMA Users
    Ronald Cowan; Fiscal Year: 2006
    ..abstract_text> ..
  70. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  71. Development of an Adult CNS Stem Cell Marking System
    Gregory Elder; Fiscal Year: 2006
    ..This system will allow the fate of nestin lineage stem cells to be followed indefinitely in adult brain irrespective of their differentiation along neuronal or non-neuronal lines. ..
  72. Estrogen receptor activation in the CNS
    JEFFREY BLAUSTEIN; Fiscal Year: 2005
    ..This initial research is essential for future work on the molecular consequences of ligand independent activation of ERs in the brain of males and females, which can then be studied in an unprecedented way. ..
  73. Utility of a Novel Carotenoid for Treating Stroke
    KEVIN SCOTT LEE; Fiscal Year: 2010
    ..The overall goal of the studies is to test whether this novel therapeutic approach is effective in protecting the brain during stroke. ..
  74. FOREBRAIN ORGANIZATION IN A NOVEL RAT
    Kevin Lee; Fiscal Year: 2003
    ..The proposed studies will provide fundamental insights into the structure, function and development of a seizure-prone brain with band heterotopia. ..
  75. Dual Sodium MRI and Proton ADC Assessment of Rodent Glioma Therapy
    VICTOR SCHEPKIN; Fiscal Year: 2007
    ..Sodium MRI applied to oncology will be evaluated for future translation to high field clinical MR scanners. ..
  76. Development of a Nestin Lineage Stem Cell Marking System
    Gregory Elder; Fiscal Year: 2002
    ..Collectively if successful these studies will provide a simple and permanent marking system for identifying and following CNS stem cells in both fetal and adult mouse brain. ..
  77. Molecular mechanism of ADNF and ADNP peptides in neuroprotection to alcohol
    Youssef Sari; Fiscal Year: 2008
    ..This data will shed light on the mechanisms governing brain ontogeny and will pave the path toward potential therapeutics against developmental insults associated with prenatal alcohol exposure. [unreadable] [unreadable] [unreadable]..
  78. PP2A-Like Constitutive ERK/MAPK Phosphatase in Brain
    Timothy Foley; Fiscal Year: 2003
    ....
  79. NEUROENDOCRINE REGULATION OF BEHAVIOR
    JEFFREY BLAUSTEIN; Fiscal Year: 2006
    ....
  80. AMP Activated Kinase in Neurons
    Gabriele Ronnett; Fiscal Year: 2008
    ..Aim 2 will study the role and regulation of AMPK in an ischemia-reperfusion model. Aim 3 will determine the mechanisms by which modulation of the FAS and CPT-1 activities alters AMPK activity and affords neuroprotection. ..
  81. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2009
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  82. RAB5 AND APP PROCESSING AS RELATED TO AGING
    Joseph Buxbaum; Fiscal Year: 2002
    ....
  83. Maternal Opioid Treatment: Human Experimental Research
    Barry Lester; Fiscal Year: 2009
    ..abstract_text> ..
  84. Olfactory Neurons--Model for PACAP Neurotrophic Function
    Gabriele Ronnett; Fiscal Year: 2005
    ..These studies will elucidate the function and mechanisms underlying bioactive peptide neurotrophism in the CNS. ..