- Extracellular N-acetylaspartate depletion in traumatic brain injury
Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
J Neurochem 96:861-9. 2006
..These results suggest that mitochondrial dysfunction is a significant contributor to poor outcome following TBI and propose extracellular NAA as a potential marker for monitoring interventions aimed at preserving mitochondrial function...
- Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
G P Saborio
Serono Pharmaceutical Research Institute, Geneva, Switzerland
Nature 411:810-3. 2001
- In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism
Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Brain Res 1380:198-205. 2011
..This study provides evidence of abnormalities in neurotransmission related to networks subserving executive control and alerting of attention, functions which have been previously implicated in ASD pathogenesis...
- Lipid rafts mediate the synaptic localization of alpha-synuclein
Doris L Fortin
Department of Neurology, Graduate Programs in Biomedical Sciences, Cell Biology and Neuroscience, University of California San Francisco School of Medicine, San Francisco, California 94143 2140, USA
J Neurosci 24:6715-23. 2004
- A general model of prion strains and their pathogenicity
MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK
Science 318:930-6. 2007
..Recent advances suggest that prions themselves are not directly neurotoxic, but rather their propagation involves production of toxic species, which may be uncoupled from infectivity...
- Quantitative MR imaging of brain iron: a postmortem validation study
Department of Neurology and Division of Neuroradiology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria
Radiology 257:455-62. 2010
..To investigate the relationship between transverse relaxation rates R2 and R2*, the most frequently used surrogate markers for iron in brain tissue, and chemically determined iron concentrations...
- Changes in glucose uptake rather than lactate shuttle take center stage in subserving neuroenergetics: evidence from mathematical modeling
Dipartimento di Fisica, Sapienza Universita di Roma, Rome, Italy
J Cereb Blood Flow Metab 30:586-602. 2010
..Overall, our results suggest that the control of carbon recruitment for neurons and astrocytes is exerted at the level of glucose uptake rather than that of lactate shuttle...
- Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound
Feng Yi Yang
Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
Int J Nanomedicine 7:723-30. 2012
- Eight prion strains have PrP(Sc) molecules with different conformations
Department of Neurology, University of California, San Francisco 94143 0518, USA
Nat Med 4:1157-65. 1998
- The ketogenic diet changes metabolite levels in hippocampal extracellular fluid
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
Neurochem Int 58:5-8. 2011
..This work will now enable other researchers to mimic the hippocampal extracellular environment in experiments aimed at deciphering the mechanisms of the KD...
- Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression
Marcus A Lawson
Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Brain Behav Immun 25:1569-75. 2011
..The results reveal a potential role for Tat in the development of comorbid depression in HIV-infected individuals...
- Darwinian evolution of prions in cell culture
Department of Infectology, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA
Science 327:869-72. 2010
..Prions, albeit devoid of a nucleic acid genome, are thus subject to mutation and selective amplification...
- Immunohistochemical localization of three different prepro-GnRHs in the brain and pituitary of the European sea bass (Dicentrarchus labrax) using antibodies to the corresponding GnRH-associated peptides
Departamento de Biologia, Facultad de Ciencias del Mar y Ambientales, Universidad de Cadiz, 11510 Puerto Real, Spain
J Comp Neurol 446:95-113. 2002
- Generating a prion with bacterially expressed recombinant prion protein
Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43210, USA
Science 327:1132-5. 2010
..Thus, as postulated by the prion hypothesis, the infectivity in mammalian prion disease results from an altered conformation of PrP...
- The GnRH system in the European sea bass (Dicentrarchus labrax)
National Center for Mariculture, Israel Oceanographic and Limnological Research, PO Box 1212, Eilat 88112, Israel
J Endocrinol 172:105-16. 2002
..These new tools will be extremely useful to study further the development, regulation and functional significance of three independent GnRH systems in the brain of vertebrate species...
- Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
J Neurochem 83:1498-508. 2002
..The results suggest that tau in S2 represents an intermediate from which insoluble tau is derived, and that phosphorylation may play a role in filament formation and/or stabilization...
- Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
R E Grahn
Department of Psychology, Behavioral Neuroscience Program, University of Colorado, Boulder, CO 80309, USA
Brain Res 826:35-43. 1999
..Inescapable tailshock led to greater serotonergic neural activity than did escapable tailshock, supporting the hypothesis that uncontrollable stressors preferentially activate serotonergic neurons in the DRN...
- Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
Nat Struct Mol Biol 18:504-6. 2011
- Cerebral microdialysis: research technique or clinical tool
M M Tisdall
Department of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery Queen Square, London WC1N 3BG, UK
Br J Anaesth 97:18-25. 2006
..Microdialysis has the potential to become an established part of mainstream multi-modality monitoring during the management of acute brain injury but at present should be considered a research tool for use in specialist centres...
- Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection
Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Brain Res Rev 56:331-45. 2007
..Here, we review the abnormal expression of PARs in the brain under pathological conditions, the functions of PARs in neurodegenerative disorders, and the molecular mechanisms involved...
- Susceptibility contrast in high field MRI of human brain as a function of tissue iron content
Advanced MRI Section, Laboratory of Functional Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1065, USA
Neuroimage 44:1259-66. 2009
..The absence of saturation effects opens the way to exploit the benefits of MRI at high field strengths for the detection of iron distributions with high sensitivity and resolution...
- p145, a major Grb2-binding protein in brain, is co-localized with dynamin in nerve terminals where it undergoes activity-dependent dephosphorylation
P S McPherson
Department of Cell Biology, Howard Hughes Medical Research Institute, Yale University School of Medicine, New Haven, Connecticut 06510
J Biol Chem 269:30132-9. 1994
..These findings suggest that p145 participates with dynamin in synaptic vesicle endocytosis and recycling...
- Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
D R Borchelt
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 17:1005-13. 1996
..These studies provide compelling support for the view that one mechanism by which these mutant PS1 cause AD is by increasing the extracellular concentration of Abeta peptides terminating at 42(43), species that foster Abeta deposition...
- Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
Central Institut of Mental Health Mannheim CIMA, University of Heidelberg, Mannheim J 5 D 68159, Germany
Brain Res Mol Brain Res 121:28-36. 2004
..Thus, a chronic reduction of BDNF protein content in adult mice is not sufficient to induce neurochemical or behavioral alterations that are reminiscent of depressive symptoms in humans...
- DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects
Sylvia E Perez
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
J Neurosci Res 88:1026-40. 2010
..Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in reducing brain insults in female AD patients...
- Alarin stimulates food intake in male rats and LH secretion in castrated male rats
Nicole Van Der Kolk
Department of Biology, Hope College, Holland, MI 49423, USA
Neuropeptides 44:333-40. 2010
..Our studies demonstrate that alarin, like other members of the galanin family, is a neuromediator of food intake and body weight...
- Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent
H V L N Swamy
Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada
J Anim Sci 80:3257-67. 2002
- A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
G F Koob
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res 848:141-52. 1999
- Human BACE forms dimers and colocalizes with APP
Freie Universitaet Berlin, Institut fuer Chemie Biochemie, Thielallee 63, Berlin D 14195, Germany
J Biol Chem 279:39710-7. 2004
..Thus, homodimerization of BACE may help the enzyme to acquire specific mechanisms to associate with its substrates to exert catalytic activity...
- Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating
Zentrum Biochemie und Molekulare Zellbiologie, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
EMBO Rep 2:634-40. 2001
..We hypothesize that hStnB regulates synaptic vesicle recycling by facilitating vesicle uncoating...
- Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide
Akhlaq A Farooqui
Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA
J Neurosci Res 85:1834-50. 2007
- Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
Department of Medicine, University of California, Los Angeles, California, USA
Eur J Neurosci 22:617-26. 2005
..The marked effect of dietary n-3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk...
- Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
Department of Molecular Biology, The Hebrew University Hadassah Medical School, and Hadassah University Hospital, Jerusalem 91120, Israel
Biochemistry 41:12868-75. 2002
..Whether these new PrP(Sc) species play a role in the biogenesis or the pathogenesis of prions remains to be established...
- Natural and synthetic prion structure from X-ray fiber diffraction
Institute for Neurodegenerative Diseases, Departments of Neurology and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:16990-5. 2009
- Genetic influence on the structural variations of the abnormal prion protein
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 97:10168-72. 2000
- Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease
S Rutger Leliveld
Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
J Neurosci 28:3839-45. 2008
..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
- The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresis
Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, 13083 970 Campinas, SP, Brazil
Brief Funct Genomic Proteomic 6:70-5. 2007
..Our results confirm that the most efficient solubilizing solution for 2-DE analysis of cytosolic and membrane Human Brain Proteins is SB combined with 4% CHAPS and 2% ASB-14...
- A vector for expressing foreign genes in the brains and hearts of transgenic mice
D R Borchelt
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
Genet Anal 13:159-63. 1996
..The MoPrP.Xho vector should be very useful in strategies designed to overexpress a variety of wild-type and disease related mutant transgenes in the heart and brain...
- Susceptibility induced gray-white matter MRI contrast in the human brain
Department of Neurology, Medical University of Graz, Austria
Neuroimage 59:1413-9. 2012
..Both, myelin and iron impact the effective transverse relaxation rate R2 significantly. Magnitude contrast is limited because it only reflects the extent but not the direction of the susceptibility shift...
- Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
Howard Hughes Medical Institute, Department of Human Genetics, Department of Pediatrics, Atlanta, GA 30322, USA
Cell 107:477-87. 2001
..We conclude that translational dysregulation of mRNAs normally associated with FMRP may be the proximal cause of fragile X syndrome, and we identify candidate genes relevant to this phenotype...
- Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
A J Nimmo
School of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD, Australia
Neuropeptides 38:40-7. 2004
- Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development
Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
Mol Psychiatry 8:19-29. 2003
- Whole-brain susceptibility mapping at high field: a comparison of multiple- and single-orientation methods
Sir Peter Mansﬁeld Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Neuroimage 53:515-25. 2010
- Estimation of brain iron concentration in vivo using a linear relationship between regional iron and apparent transverse relaxation rate of the tissue water at 4.7T
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Magn Reson Med 62:1326-30. 2009
..When accounting for f(M) in the analysis, the apparent transverse relaxation rate seems to give a significantly better estimation of regional [Fe]...
- Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria
Fiona E Lovegrove
Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5G 2C4
Am J Pathol 171:1894-903. 2007
- Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Magn Reson Med 50:24-32. 2003
..The current data may serve as a reference for studies focused on developmental defects and pathologies using neonatal rat models...
- Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry
Ann M Knolhoff
Department of Chemistry and the Beckman Institute, University of Illinois, Urbana, Illinois 61801, United States
Anal Chem 85:3136-43. 2013
..Because the CE-MS and expression profiling are both amenable to small-volume analysis, this integrated analysis is applicable to a range of volume-limited biological systems...
- Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats
Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Eur J Neurosci 26:1845-52. 2007
..The present data suggest that while overexpression of APP in rats may provide some histological neuroprotection in the event of cerebral ischaemia, this does not translate into significant functional recovery...
- On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field
Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 49:193-8. 2010
..This result suggests that endogenous deoxy-hemoglobin has no significant contribution to phase contrast between gray and white matter...
- Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings
Brain Imaging and Analysis Center, Department of Biomedical Engineering, School of Medicine, Duke University, Durham, NC 27705, USA
Neuroimage 59:2088-97. 2012
- Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location
Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
J Neurotrauma 28:849-60. 2011
..Decreases in perfusion and oxygenation were associated with deteriorating neurochemistry and these effects were more pronounced in perilesional tissue and when cerebrovascular reactivity was impaired...
- MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuroimage 59:2625-35. 2012
- Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
R J Wurtman
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Nutr Health Aging 13:189-97. 2009
..A treatment that increased the formation of neurites and dendritic spines might reverse this loss, thereby increasing the number of synapses and slowing the decline in cognition...
- Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry
Ioana M Taban
FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
J Am Soc Mass Spectrom 18:145-51. 2007
..To reduce the extended measuring times involved, it is recommended to restrict the FTICR-MS analyses to areas of interest as can be preselected by other, faster imaging methods...
- Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism
Medivation, Inc, San Francisco, California 94105, USA
J Pharmacol Exp Ther 333:748-57. 2010
..The cognition-enhancing effects of Dimebon are unlikely to be mediated by AChE inhibition or NMDA receptor antagonism, and its mechanism of action appears to be distinct from currently approved medications for AD...
- Clinical cerebral microdialysis: a methodological study
P J Hutchinson
Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
J Neurosurg 93:37-43. 2000
- ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein
Center for Research in Paediatric Orthopaedics, Shriners Hospital, Tampa, FL 33612, U S A
Biochem J 377:787-95. 2004
- Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Suzanne E Wahrle
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 118:671-82. 2008
..These data support the conclusions that increased ABCA1-mediated lipidation of apoE in the CNS can reduce amyloid burden and that increasing ABCA1 function may have a therapeutic effect on AD...
- Dopamine covalently modifies and functionally inactivates parkin
Matthew J LaVoie
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, HIM 7th Floor, Boston, Massachusetts 02115, USA
Nat Med 11:1214-21. 2005
- Immunolocalization of CCK1R in rat brain using a new anti-peptide antibody
Linda D Mercer
Department of Pharmacology, Monash University, Clayton, VIC 3800, Australia
Neurosci Lett 359:109-13. 2004
..The widespread distribution of CCK1R has implications for the functional roles of these receptors in brain. The high titre and low background seen with this new antiserum makes it of great value for cell and tissue research...
- Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study
Chuck T Chen
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building, 150 College St, Room 306, Toronto, Ontario, Canada M5S 3E2
Prostaglandins Leukot Essent Fatty Acids 80:157-63. 2009
..These findings suggest that low levels of EPA in brain phospholipids compared to DHA may be the result of its rapid beta-oxidation upon uptake by the brain...
- Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat
Institute of Physiological Psychology, Heinrich Heine University of Dusseldorf, Universitatsstr 1, D 40225, Dusseldorf, Germany
Neurobiol Aging 23:135-43. 2002
- Characterization and distribution of angiotensin II receptor subtypes in the mouse brain
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892 1514, USA
Eur J Pharmacol 348:101-14. 1998
..Our data also form the basis for future studies of mouse models such as those with angiotensin receptor gene deficiencies...
- Cytokine signals propagate through the brain
CNRS INSERM Centre de Pharmacologie Endocrinologie, Montpellier, France
Mol Psychiatry 5:604-15. 2000
..This elucidation is a prerequisite for better understanding of reciprocal interactions between nervous, endocrine and immune systems...
- Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice
Laboratoire de Neuropharmacologie, Universite Paris Sud, EA 3544, Faculte de Pharmacie, 5, rue J B Clement, Tour D1, 2e etage, Chatenay Malabry Cedex F 92296, France
Neuropharmacology 55:1006-14. 2008
..In view of developing new antidepressant drug strategy, a poly-therapy combining BDNF with a chronic SSRI treatment could thus improve the efficacy of current medications...
- A cellular gene encodes scrapie PrP 27-30 protein
Cell 40:735-46. 1985
..No PrP-related nucleic acids were found in purified preparations of scrapie prions, indicating that PrP 27-30 is not encoded by a nucleic acid carried within the infectious particles...
- The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
K O Cho
Division of Biology, California Institute of Technology, Pasadena 91125
Neuron 9:929-42. 1992
..The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain...
- Brain spectrin: of mice and men
S R Goodman
Department of Structural and Cellular Biology, University of South Alabama College of Medicine, Mobile 36688, USA
Brain Res Bull 36:593-606. 1995
..We finish with a discussion of the value of spectrin and ankyrin-deficient mouse models in deciphering spectrin function in neural tissue...
- Gray and white matter brain chemistry in young children with autism
Seth D Friedman
Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
Arch Gen Psychiatry 63:786-94. 2006
..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
- Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner
Department of Prion Research, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
J Virol 81:12889-98. 2007
..The mechanism of the prion strain-dependent effectiveness needs to be elucidated and managed. Nevertheless, the identification of an orally available amyloidophilic chemical encourages the pursuit of chemotherapy for prion diseases...
- Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity
Mekky M Abouzied
Institut fur Physiologische Chemie, Rheinische Friedrich Wilhelms Universitat, Nussallee 11, 53115 Bonn, Germany
Biochem J 378:169-76. 2004
..In addition, their simultaneous expression in the same cell and their different subcellular localization in cultured neurons suggest different functions of HDGF and HRP-3 within single cells...
- Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry
A F Maarten Altelaar
FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
Anal Chem 78:734-42. 2006
- Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice
Division of Neurosciences, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
Behav Brain Res 145:31-6. 2003
..Our present results support the earlier electrophysiological evidences that harmaline-induced tremor originates from ON, and confirm the role of 5-HT in the genesis of this motor neuronal dysfunction...
- Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase
Y C Chang
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
J Neurosci 8:2123-30. 1988
..GAD-6 does not recognize the 63 kDa band. In Western blots of unfractionated homogenates of the whole brain, the only band recognized by GAD-6 is a 59 kDa band.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism
Carl Henrik Nordstrom
Department of Clinical Neuroscience, Lund University Hospital, Lund, Sweden
Anesthesiology 98:809-14. 2003
- Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
Kim N Green
Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4545, USA
J Neurosci 27:4385-95. 2007
..Collectively, these results suggest that DHA and DPAn-6 supplementations could be a beneficial natural therapy for AD...
- Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry
Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Anal Biochem 302:199-212. 2002
- Stress and neuroactive steroids
M L Barbaccia
Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, Italy
Int Rev Neurobiol 46:243-72. 2001
..This chapter summarizes observations from our laboratories and others, suggesting that neurosteroids and GABAergic transmission are important contributors to the changes in emotional state induced by environmental stress...
- 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
Nat Neurosci 8:828-34. 2005
- Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion
C A Llewelyn
National Blood Service, Cambridge Centre, Cambridge CB2 2PT, UK
Lancet 363:417-21. 2004
..We aimed to identify whether vCJD is transmissible through blood transfusion...
- Glutathione pathways in the brain
Physiologisch chemisches Institut der Universität Tübingen, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
Biol Chem 384:505-16. 2003
..In addition, implications of disturbed GSH pathways in brain for neurodegenerative diseases will be discussed...
- Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Ian A Simpson
Department of Neural and Behavioral Sciences College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
J Cereb Blood Flow Metab 27:1766-91. 2007
- Sporadic and familial CJD: classification and characterisation
Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Br Med Bull 66:213-39. 2003
..The clinical and pathological features are summarised for each sporadic CJD subtype and familial CJD haplotype...
- The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
B C Campbell
Department of Pathology, The University of Melbourne, Victoria, Australia
J Neurochem 76:87-96. 2001
..Highly insoluble alpha SN is not involved in the pathogenesis of MSA. It is therefore possible that buffered saline-soluble or detergent-soluble forms of alpha SN are involved in the pathogenesis of other alpha SN-related diseases...
- Automatic quantitation of localized in vivo 1H spectra with LCModel
S W Provencher
Max Planck Institute for Biophysical Chemistry, D 37070 Gottingen, Germany
NMR Biomed 14:260-4. 2001
..LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS...
- GABAergic dysfunction in mood disorders
Biological Psychiatry Unit, IRCCS S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
Mol Psychiatry 8:721-37, 715. 2003
..In this paper, we discuss the status of GABAergic hypothesis of mood disorders and suggest possible directions for future preclinical and clinical research in this area...
- Synthetic mammalian prions
Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
Science 305:673-6. 2004
..Neuropathological findings suggest that a novel prion strain was created. Our results provide compelling evidence that prions are infectious proteins...
- Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
G M Pasinetti
Neuroinflammation Research Center, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurosci Res 65:471-6. 2001
..The study suggests new means to dissect and classify stages of AD dementia, or neuropathology, at the molecular level...
- Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
K G Mountjoy
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201 3098
Mol Endocrinol 8:1298-308. 1994
..The high degree of conservation, distinct pharmacology, and unique neuronal distribution of the MC4 receptor suggest specific and complex roles for the melanocortin peptides in neuroendocrine and autonomic control...
- Serotonin and GABA are colocalized in restricted groups of neurons in the larval sea lamprey brain: insights into the early evolution of neurotransmitter colocalization in vertebrates
Department of Cell Biology and Ecology, Faculty of Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
J Anat 215:435-43. 2009
..Cotransmission by release of 5-HT and GABA by the here-described lamprey brain neurons is proposed...
- Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Mol Cell Neurosci 26:166-81. 2004
..TK+ mice. Altogether, overexpression of the trkB.TK+ receptor postnatally leads to selective activation of trkB signaling pathways and enhanced learning and memory...
- Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier
University of Zurich, Institute of Pharmacology and Toxicology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Neuroscience 138:159-69. 2006
- Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice
Santhera Pharmaceuticals Switzerland Ltd, Liestal, Switzerland
PLoS ONE 4:e4774. 2009
..e. to increase food intake and to reduce energy expenditure...
- Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum
L S Janis
Department of Cell Biology and Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Neurosci 19:4962-71. 1999
..These observations implicate selective interactions between ephrin-A molecules and EphA RTKs as potential mechanisms for regulating the compartmental organization of the striatum...
- microRNA modulation of circadian-clock period and entrainment
Hai Ying M Cheng
Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
Neuron 54:813-29. 2007
..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment...
- Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse
Department of Clinical Gene Therapy, Osaka University, Yamadaoka, Osaka 565 0871, Japan
Neuroscience 186:110-9. 2011
- Molecular taxonomy of major neuronal classes in the adult mouse forebrain
Department of Biology and National Center for Behavioral Genomics, Brandeis University, MS 008, 415 South Street, Waltham, Massachusetts 02454 9110, USA
Nat Neurosci 9:99-107. 2006
..This dataset should be useful for the classification of unknown neuronal subtypes, the investigation of specifically expressed genes and the genetic manipulation of specific neuronal circuit elements...
- Influence of the normalization template on the outcome of statistical parametric mapping of PET scans
J D Gispert
Medical Imaging Laboratory, Hospital Universitario Gregorio Maranon, Madrid, Spain
Neuroimage 19:601-12. 2003
..These results show that the use of the standard template under inappropriate conditions (different tracer or mental state) may lead to inconsistent interpretations of the statistical analysis...
- Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients
Richard E Harris
Assistant Professor, Research Specialist, Professor, Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan Assistant Professor, Research Fellow, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Senior Director, Director, Pfizer Incorporated, Groton, Connecticut Professor, Department of Radiology, Division of Neuroradiology, University of Michigan, and Department of Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden Assistant Professor, Department of Radiology, Division of Neuroradiology, University of Michigan, and Ann Arbor VA Healthcare System Assistant Professor, Department of Radiology, Division of Neuroradiology, University of Michigan Associate Professor, Department of Neurology, Bergmannsheil, Berufsgenossenschaftliche Universitätsklinik, Ruhr Universitat Bochum, Bochum, Germany
Anesthesiology 119:1453-64. 2013
..However, human brain neuroimaging techniques enable the assessment of functional and neurochemical alterations in patients experiencing chronic pain and how these factors may dynamically change with pharmacologic treatment...
- Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS/MS: identification of ceramides containing sphingadienine
Institut National de la Santé et de la Recherche Médicale U495, Laboratoire de Neurochimie, Hopital de la Salpetriere, 75651 Paris 13, France
J Lipid Res 45:281-6. 2004
..Sphingadienine is present in galactosylceramide and sulfatides. Free ceramides contain the three types of bases. Thus, there could be two separate pools of free ceramides (d18:1, d18:2 and d20:1, d18:1) as precursors of complex SGL...
- Phase contrast imaging in neonates
Department of Biomedical Magnetic Resonance, Faculty for Natural Sciences, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Haus 65, D 39120, Magdeburg, Germany
Neuroimage 55:1068-72. 2011
..Therefore, magnetic resonance phase imaging is suggested as a novel tool to study neonatal brain development and pathologies in neonates...