anaerobiosis

Summary

Summary: The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Top Publications

  1. ncbi Spreading dead zones and consequences for marine ecosystems
    Robert J Diaz
    Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
    Science 321:926-9. 2008
  2. pmc Biochemistry and evolution of anaerobic energy metabolism in eukaryotes
    MIKLOS MULLER
    The Rockefeller University, New York, New York, USA
    Microbiol Mol Biol Rev 76:444-95. 2012
  3. ncbi Nitrite-driven anaerobic methane oxidation by oxygenic bacteria
    Katharina F Ettwig
    Radboud University Nijmegen, IWWR, Department of Microbiology, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
    Nature 464:543-8. 2010
  4. ncbi Deciphering the evolution and metabolism of an anammox bacterium from a community genome
    Marc Strous
    Department of Microbiology, IWWR, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Nature 440:790-4. 2006
  5. ncbi Inhibition of anaerobic digestion process: a review
    Ye Chen
    Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh, NC 27695 7625, USA
    Bioresour Technol 99:4044-64. 2008
  6. ncbi Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis
    Sang Sun Yoon
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Dev Cell 3:593-603. 2002
  7. ncbi Anaerobic ammonium oxidation by anammox bacteria in the Black Sea
    Marcel M M Kuypers
    Max Planck Institute for Marine Microbiology, Department of Biogeochemistry, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 422:608-11. 2003
  8. ncbi Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors
    G Unden
    Institut für Mikrobiologie und Weinforschung, Universitat Mainz, Germany
    Biochim Biophys Acta 1320:217-34. 1997
  9. ncbi Molecular mechanism of anaerobic ammonium oxidation
    Boran Kartal
    Institute for Water and Wetland Research, Department of Microbiology, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands
    Nature 479:127-30. 2011
  10. ncbi Denitrification as the dominant nitrogen loss process in the Arabian Sea
    B B Ward
    Department of Geosciences, Princeton University, Princeton, New Jersey 08544, USA
    Nature 461:78-81. 2009

Research Grants

  1. Symbiosis of E. coli and the Intestinal Microbiota in a Mouse Model
    Tyrrell Conway; Fiscal Year: 2013
  2. Oxygen and Streptococcus mutans Virulence
    Robert A Burne; Fiscal Year: 2010
  3. ENZYMES OF DINITROGEN REDUCTION
    WILLIAM ORME JOHNSON; Fiscal Year: 1991
  4. BACTERICIDAL ACTIVITY OF LACTOFERRIN ON ORAL FLORA
    Roland Arnold; Fiscal Year: 1993
  5. FUNCTION OF GONOCOCCAL ANAEROBICALLY INDUCED PROTEINS
    Virginia Clark; Fiscal Year: 2007
  6. ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    HAROLD DRAKE; Fiscal Year: 1990
  7. GENETIC ANALYSIS OF THE RECA PROTEIN OF E. COLI
    George Weinstock; Fiscal Year: 1991
  8. ANALYSIS OF THE ANAEROBIC-STRESS RESPONSE IN MAIZE
    Martin Sachs; Fiscal Year: 1992
  9. Isolation of New Antibiotics From Soil Microorganisms
    Michael Davis; Fiscal Year: 2004
  10. REGULATORY MECHANISMS OF AN INDUCIBLE GENE
    John Walker; Fiscal Year: 1992

Detail Information

Publications312 found, 100 shown here

  1. ncbi Spreading dead zones and consequences for marine ecosystems
    Robert J Diaz
    Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
    Science 321:926-9. 2008
    ..Dead zones have now been reported from more than 400 systems, affecting a total area of more than 245,000 square kilometers, and are probably a key stressor on marine ecosystems...
  2. pmc Biochemistry and evolution of anaerobic energy metabolism in eukaryotes
    MIKLOS MULLER
    The Rockefeller University, New York, New York, USA
    Microbiol Mol Biol Rev 76:444-95. 2012
    ..Diversified eukaryotic lineages have retained the same enzymes of anaerobic ATP synthesis, in line with geochemical data indicating low environmental oxygen levels while eukaryotes arose and diversified...
  3. ncbi Nitrite-driven anaerobic methane oxidation by oxygenic bacteria
    Katharina F Ettwig
    Radboud University Nijmegen, IWWR, Department of Microbiology, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
    Nature 464:543-8. 2010
    ..Because nitrogen oxides were already present on early Earth, our finding opens up the possibility that oxygen was available to microbial metabolism before the evolution of oxygenic photosynthesis...
  4. ncbi Deciphering the evolution and metabolism of an anammox bacterium from a community genome
    Marc Strous
    Department of Microbiology, IWWR, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Nature 440:790-4. 2006
    ..Most significantly, we identified candidate genes responsible for ladderane biosynthesis and biological hydrazine metabolism, and discovered unexpected metabolic versatility...
  5. ncbi Inhibition of anaerobic digestion process: a review
    Ye Chen
    Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh, NC 27695 7625, USA
    Bioresour Technol 99:4044-64. 2008
    ..Co-digestion with other waste, adaptation of microorganisms to inhibitory substances, and incorporation of methods to remove or counteract toxicants before anaerobic digestion can significantly improve the waste treatment efficiency...
  6. ncbi Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis
    Sang Sun Yoon
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Dev Cell 3:593-603. 2002
    ..Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa...
  7. ncbi Anaerobic ammonium oxidation by anammox bacteria in the Black Sea
    Marcel M M Kuypers
    Max Planck Institute for Marine Microbiology, Department of Biogeochemistry, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 422:608-11. 2003
    ..The widespread occurrence of ammonium consumption in suboxic marine settings indicates that anammox might be important in the oceanic nitrogen cycle...
  8. ncbi Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors
    G Unden
    Institut für Mikrobiologie und Weinforschung, Universitat Mainz, Germany
    Biochim Biophys Acta 1320:217-34. 1997
    ..Reductive activation could be achieved by cellular reductants in the absence of O2. In addition, O2 may cause destruction and loss of the FeS cluster. It is not known whether this process is required for regulation of FNR function...
  9. ncbi Molecular mechanism of anaerobic ammonium oxidation
    Boran Kartal
    Institute for Water and Wetland Research, Department of Microbiology, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands
    Nature 479:127-30. 2011
    ..Furthermore, they reinforce the role of nitric oxide in the evolution of the nitrogen cycle...
  10. ncbi Denitrification as the dominant nitrogen loss process in the Arabian Sea
    B B Ward
    Department of Geosciences, Princeton University, Princeton, New Jersey 08544, USA
    Nature 461:78-81. 2009
    ..The large contribution of denitrification to N(2) loss in the Arabian Sea indicates the global significance of denitrification to the oceanic nitrogen budget...
  11. pmc Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown function
    Yisheng Kang
    Department of Genetics, 425 Henry Mall, University of Wisconsin, Madison, WI 53706, USA
    J Bacteriol 187:1135-60. 2005
    ..We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized...
  12. ncbi Reverse methanogenesis: testing the hypothesis with environmental genomics
    Steven J Hallam
    Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA
    Science 305:1457-62. 2004
    ..These genome-based observations support previous hypotheses and provide an informed foundation for metabolic modeling of anaerobic methane oxidation...
  13. pmc Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditions
    Svetlana Alexeeva
    Laboratory for Microbiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
    J Bacteriol 185:204-9. 2003
    ..coli to changes in oxygen availability through the complete range from anaerobiosis to full aerobiosis (S. Alexeeva, B. de Kort, G. Sawers, K. J. Hellingwerf, and M. J. Teixeira de Mattos, J...
  14. ncbi Methanogenic pathway and community structure in a thermophilic anaerobic digestion process of organic solid waste
    Daisuke Sasaki
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Biosci Bioeng 111:41-6. 2011
    ..These results imply that the microbial community in the thermophilic degrading process of organic solid waste consists exclusively of unidentified bacteria, which efficiently remove acetate through a non-aceticlastic oxidative pathway...
  15. ncbi Biochemistry and molecular biology of anammox bacteria
    Mike S M Jetten
    Department of Microbiology, IWWR, Faculty of Science, Radboud University of Nijmegen, Toernooiveld 1, Nijmegen, The Netherlands
    Crit Rev Biochem Mol Biol 44:65-84. 2009
    ..Application of the anammox process offers an attractive alternative to current wastewater treatment systems for the removal of ammonia-nitrogen. Currently, at least five full scale reactor systems are operational...
  16. ncbi Minimal metabolic engineering of Saccharomyces cerevisiae for efficient anaerobic xylose fermentation: a proof of principle
    Marko Kuyper
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    FEMS Yeast Res 4:655-64. 2004
    ..cerevisiae gene products can subsequently be optimised via evolutionary engineering. These results provide a gateway towards commercially viable ethanol production from xylose with S. cerevisiae...
  17. pmc FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar Typhimurium (ATCC 14028s)
    Ryan C Fink
    Department of Microbiology, North Carolina State University, Raleigh, NC 27695 7615, USA
    J Bacteriol 189:2262-73. 2007
    ..The inability of the mutant to survive inside macrophages is likely due to its sensitivity to the reactive oxygen species generated by NADPH phagocyte oxidase...
  18. ncbi Anaerobic ammonium-oxidizing bacteria in marine environments: widespread occurrence but low diversity
    Markus C Schmid
    Department of Microbiology, IWWR, Radboud University Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Environ Microbiol 9:1476-84. 2007
    ..This study showed the ubiquitous presence of anammox bacteria in anoxic marine ecosystems, supporting previous observations on the importance of anammox for N cycling in marine environments...
  19. ncbi Diversity of ammonium-oxidizing bacteria in a granular sludge anaerobic ammonium-oxidizing (anammox) reactor
    Zhe Xue Quan
    Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Environ Microbiol 10:3130-9. 2008
    ..The partial sequence of hydrazine-oxidizing enzyme (hzo) of dominant AnAOB was also identified using new designed primers. Based on this analysis, we propose to tentatively name this new AnAOB Candidatus'Jettenia asiatica'...
  20. pmc Production of N(2) through anaerobic ammonium oxidation coupled to nitrate reduction in marine sediments
    Bo Thamdrup
    Danish Center for Earth System Science, Institute of Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Appl Environ Microbiol 68:1312-8. 2002
    ..The process can explain ammonium deficiencies in anoxic waters and sediments, and it may contribute significantly to oceanic nitrogen budgets...
  21. pmc Reprogramming of anaerobic metabolism by the FnrS small RNA
    Sylvain Durand
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Mol Microbiol 75:1215-31. 2010
    ..We thus suggest that FnrS extends the FNR regulon and increases the efficiency of anaerobic metabolism by repressing the synthesis of enzymes that are not needed under these conditions...
  22. ncbi Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals
    H O Portner
    Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
    Naturwissenschaften 88:137-46. 2001
    ..As a corollary, capacity limitations at a complex level of organisation, the oxygen delivery system, define thermal tolerance limits before molecular functions become disturbed...
  23. pmc The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy
    Rachel L Leistikow
    University of Colorado Denver, School of Medicine, Department of Microbiology, P18 9115, 12800 East 19th Avenue, PO Box 6511, Aurora, CO 80045, USA
    J Bacteriol 192:1662-70. 2010
    ..tuberculosis to survive in the absence of respiration and to successfully transition rapidly between respiring and nonrespiring conditions without loss of viability...
  24. pmc Energetics of syntrophic cooperation in methanogenic degradation
    B Schink
    Fakultat fur Biologie, Universitat Konstanz, Germany
    Microbiol Mol Biol Rev 61:262-80. 1997
    ..These findings allow us to understand the energy economy of these bacteria on the basis of concepts derived from the bioenergetics of other microorganisms...
  25. pmc Translational regulation of gene expression by an anaerobically induced small non-coding RNA in Escherichia coli
    Anders Boysen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
    J Biol Chem 285:10690-702. 2010
    ....
  26. ncbi Evidence for complete denitrification in a benthic foraminifer
    Nils Risgaard-Petersen
    Department of Marine Ecology, National Environmental Research Institute, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    Nature 443:93-6. 2006
    ....
  27. pmc Plant oxygen sensing is mediated by the N-end rule pathway: a milestone in plant anaerobiosis
    Rashmi Sasidharan
    Plant Ecophysiology, Institute of Environmental Biology, Utrecht University, Utrecht, The Netherlands
    Plant Cell 23:4173-83. 2011
    ....
  28. pmc Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture
    Jaiyanth Daniel
    University of Central Florida, Biomolecular Science Center, BMS 136, 4000 Central Florida Blvd, Orlando, FL 32816 2364, USA
    J Bacteriol 186:5017-30. 2004
    ..Therefore, TG synthesis may be an appropriate target for novel antilatency drugs that can prevent the organism from surviving dormancy and thus assist in the control of tuberculosis...
  29. ncbi The enigma of prokaryotic life in deep hypersaline anoxic basins
    Paul W J J van der Wielen
    Laboratory of Microbial Ecology, University of Groningen, 9751 NN Haren, Netherlands
    Science 307:121-3. 2005
    ..Furthermore, we demonstrated the presence of a unique, metabolically active microbial community in the Discovery basin, which is one of the most extreme terrestrial saline environments known, as it is almost saturated with MgCl2 (5 M)...
  30. ncbi Quantitative proteomics and transcriptomics of anaerobic and aerobic yeast cultures reveals post-transcriptional regulation of key cellular processes
    Marco J L de Groot
    Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Microbiology 153:3864-78. 2007
    ..S. cerevisiae is therefore an ideal eukaryotic model to study physiological adaptation to anaerobiosis. Recent transcriptome analyses have identified hundreds of genes that are transcriptionally regulated by oxygen ..
  31. pmc The LysR-type virulence activator AphB regulates the expression of genes in Vibrio cholerae in response to low pH and anaerobiosis
    Gabriela Kovacikova
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Bacteriol 192:4181-91. 2010
    ..Further experiments show that the regulation of cadC by AphB in response to low pH and anaerobiosis is mirrored in the heterologous organism Escherichia coli, is independent of the global regulators Fnr and ..
  32. ncbi The NADH oxidase of Streptococcus pneumoniae: its involvement in competence and virulence
    I Auzat
    Laboratoire d Enzymologie et de Biochimie structurale du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Mol Microbiol 34:1018-28. 1999
    ..This work establishes, for the first time, the role of O2 in the regulation of pneumococcal transformability and virulence...
  33. ncbi Candidatus "Scalindua brodae", sp. nov., Candidatus "Scalindua wagneri", sp. nov., two new species of anaerobic ammonium oxidizing bacteria
    Markus Schmid
    Kluyver Laboratory for Biotechnology, Delft University of Technology, Delft, The Netherlands
    Syst Appl Microbiol 26:529-38. 2003
    ..Simultaneously, another new species of the same genus, Candidatus "Scalindua sorokinii", was detected in the water column of the Black Sea, making this genus the most widespread of all anammox bacteria described so far...
  34. ncbi Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons
    Katharina Trunk
    Institute of Microbiology, Technische Universitat Braunschweig, Spielmannstr 7, D 38106 Braunschweig, Germany
    Environ Microbiol 12:1719-33. 2010
    ..The combination with the experimental data unambiguously identified 130 new members for the Anr and Dnr regulons. The basis for the understanding of two regulons of P. aeruginosa central to biofilm formation and infection is now defined...
  35. ncbi Development of high-rate anaerobic ammonium-oxidizing (anammox) biofilm reactors
    Ikuo Tsushima
    Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060 8628, Japan
    Water Res 41:1623-34. 2007
    ..e., simultaneous consumption of NH(4)(+) and NO(2)(-)) of 4.45 g-N of (NH(4)(+)+NO(2)(-))m(-2)day(-1) was detected in the upper 800 microm of the biofilm, which was consistent with the spatial distribution of anammox bacteria...
  36. ncbi Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniae
    Stella Pesakhov
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences P O Box 151, Beer Sheva 84101, Israel
    Biochim Biophys Acta 1768:590-7. 2007
    ..We suggest that endogenous ROS play an important regulatory role in membrane adaptation, allowing the survival of this anaerobic organism at aerobic environments of the host...
  37. ncbi Hypoxia: a window into Mycobacterium tuberculosis latency
    Tige R Rustad
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Cell Microbiol 11:1151-9. 2009
    ..tuberculosis hypoxic responses. We also examine the role of these responses in tuberculosis latency, and identify promising avenues for future studies...
  38. pmc Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin
    D R Sherman
    Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 98:7534-9. 2001
    ..When we interrupted expression of this operon by targeted disruption of the upstream gene Rv3134c, the hypoxic regulation of acr was eliminated. These results suggest a possible role for Rv3132c/3133c/3134c in mycobacterial latency...
  39. ncbi Biogeographical distribution of diverse anaerobic ammonium oxidizing (anammox) bacteria in Cape Fear River Estuary
    Olivia R Dale
    Department of Biology and Marine Biology, University of North Carolina Wilmington, NC 28403, USA
    Environ Microbiol 11:1194-207. 2009
    ..Thus, we demonstrated a biogeographical distribution of diverse anammox bacteria influenced by salinity, and provide evidence to link anammox abundance and activities in estuarine sediments...
  40. pmc Role of the transcriptional activator AppY in regulation of the cyx appA operon of Escherichia coli by anaerobiosis, phosphate starvation, and growth phase
    T Atlung
    Department of Chemistry and Life Sciences, Roskilde University, Denmark
    J Bacteriol 176:5414-22. 1994
    ..The appY mutation eliminated induction of the cyx promoter by anaerobiosis and severely reduced induction of this promoter by phosphate starvation and upon entry into stationary phase ..
  41. ncbi Hypoxia-related processes in the Baltic Sea
    Daniel J Conley
    GeoBiosphere Science Centre, Lund University, SE 223 62 Lund, Sweden
    Environ Sci Technol 43:3412-20. 2009
    ..Nutrient load reductions are needed to reduce the extent, severity, and effects of hypoxia...
  42. ncbi Cytochrome cd1-containing nitrite reductase encoding gene nirS as a new functional biomarker for detection of anaerobic ammonium oxidizing (Anammox) bacteria
    Meng Li
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China
    Environ Sci Technol 45:3547-53. 2011
    ....
  43. ncbi Anaerobic ammonium oxidation (anammox) in different natural ecosystems
    Bao Lan Hu
    Department of Environmental Engineering, Zhejiang University, Hangzhou 310058, China
    Biochem Soc Trans 39:1811-6. 2011
    ....
  44. pmc Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses
    Mai Ping Tan
    Novartis Institute for Tropical Diseases, Singapore, Singapore
    PLoS ONE 5:e13356. 2010
    ..Overall, these data shed light on a new role for nitrate respiration in protecting M. tuberculosis from acidity and reactive nitrogen species, two environmental stresses likely encountered by the pathogen during the course of infection...
  45. pmc A novel nucleoid protein of Escherichia coli induced under anaerobiotic growth conditions
    Jun Teramoto
    Department of Frontier Bioscience, Hosei University, Koganei, Tokyo 184 8584, Japan
    Nucleic Acids Res 38:3605-18. 2010
    ..We then propose that YgiP is a novel nucleoid protein of E. coli under anaerobiosis and propose to rename it Dan (DNA-binding protein under anaerobic conditions).
  46. pmc Phenotypic repertoire of the FNR regulatory network in Escherichia coli
    Dean A Tolla
    Biomedical Engineering Department, One Shields Ave, University of California, Davis, CA 95616, USA
    Mol Microbiol 79:149-65. 2011
    ....
  47. ncbi The 'porin-cytochrome' model for microbe-to-mineral electron transfer
    David J Richardson
    Centre for Molecular and Structural Biochemistry, School of Biological Sciences and School of Chemistry, University of East Anglia, Norwich NR47TJ, UK
    Mol Microbiol 85:201-12. 2012
    ....
  48. pmc Evolution of the metabolic and regulatory networks associated with oxygen availability in two phytopathogenic enterobacteria
    Lavanya Babujee
    Biotechnology Center, University of Wisconsin Madison, WI, USA
    BMC Genomics 13:110. 2012
    ..1% glucose) with and without O2...
  49. ncbi Effect of oxygen on the Escherichia coli ArcA and FNR regulation systems and metabolic responses
    Sagit Shalel Levanon
    Department of Biochemistry and Cell Biology, MS 140, 6100 Main St, Rice University, Houston, TX 77005 1892, USA
    Biotechnol Bioeng 89:556-64. 2005
    ..The activity of FNR-regulated pathways in the arcA mutant strain is correlated with the high redox potential obtained under microaerobic growth...
  50. pmc Influence of environmental conditions on methanogenic compositions in anaerobic biogas reactors
    Dimitar Karakashev
    Environment and Resources DTU, Technical University of Denmark, Bygningstorvet, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 71:331-8. 2005
    ..The impact of the original inoculum used for the reactor start-up was also investigated by assessment of the present population in the reactor. The inoculum population appeared to have no influence on the eventual population...
  51. pmc Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations
    Matthew D Rolfe
    Department of Molecular Biology and Biotechnology, The Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK
    Open Biol 2:120091. 2012
    ..Thus, this approach illustrates how systematic examination of regulatory responses in stable and dynamic environments yields new mechanistic insights into adaptive processes...
  52. ncbi Interaction between temperature and ammonia in mesophilic digesters for animal waste treatment
    Marcelo L Garcia
    Department of Energy, Environmental and Chemical Engineering, Washington University in Saint Louis, Saint Louis, MO 63130, USA
    Water Res 43:2373-82. 2009
    ..We extrapolated our data to correlate temperature, ammonia, and methane yield and to hypothesize that the difference between high- and low-ammonia reactors is negligible at the optimum mesophilic temperature of 38 degrees C...
  53. ncbi Detection of active, potentially acetate-oxidizing syntrophs in an anaerobic digester by flux measurement and formyltetrahydrofolate synthetase (FTHFS) expression profiling
    Tomoyuki Hori
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Microbiology 157:1980-9. 2011
    ..These transcripts arose from phylogenetically presumed homoacetogens. The results of this study demonstrate that hitherto unidentified phylotypes of homoacetogens are responsible for syntrophic acetate oxidation in an anaerobic digester...
  54. ncbi Methane-consuming archaea revealed by directly coupled isotopic and phylogenetic analysis
    V J Orphan
    Monterey Bay Aquarium Research Institute, Moss Landing, CA 95039, USA
    Science 293:484-7. 2001
    ..Our results demonstrate the feasibility of simultaneous determination of the identity and the metabolic activity of naturally occurring microorganisms...
  55. pmc Host-derived nitrate boosts growth of E. coli in the inflamed gut
    Sebastian E Winter
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA, USA
    Science 339:708-11. 2013
    ..Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration...
  56. pmc Effect of biowaste sludge maturation on the diversity of thermophilic bacteria and archaea in an anaerobic reactor
    M Goberna
    Universitat Innsbruck, Institut fur Mikrobiologie, Technikerstrasse 25 d, 6020, Innsbruck, Austria
    Appl Environ Microbiol 75:2566-72. 2009
    ..We suggest that the environmental filter imposed by the saline conditions (20 g liter(-1)) selected a stable community of halotolerant and halophilic prokaryotes...
  57. ncbi Oxygen and the spatial structure of microbial communities
    Tom Fenchel
    Marine Biological Laboratory, University of Copenhagen, Strandpromenaden 5, DK 3000 Helsingør, Denmark
    Biol Rev Camb Philos Soc 83:553-69. 2008
    ..Deep lakes undergo thermal stratification in warm waters, resulting in seasonal anaerobiosis below the thermocline, and lakes with a permanent pycnocline often have permanent anoxic deep water...
  58. ncbi Phylogenetic analysis and fluorescence in situ hybridization detection of archaeal and bacterial endosymbionts in the anaerobic ciliate trimyema compressum
    Naoya Shinzato
    Center of Molecular Biosciences, University of the Ryukyus, Nishihara cho, Nakagami gun, Okinawa, 903 0213, Japan
    Microb Ecol 54:627-36. 2007
    ..compressum are more complicated than hitherto proposed...
  59. ncbi Effect of time of day on aerobic contribution to the 30-s Wingate test performance
    Nizar Souissi
    Research Unit, Evaluation, Sport, Health, National Centre of Medicine and Science in Sport, Route de l Aéroport, Sfax 3000, Tunisia
    Chronobiol Int 24:739-48. 2007
    ..Altogether, these results indicate that the time-of-day effect on performances during the Wingate test is mainly due to better aerobic participation in energy production during the test in the afternoon than in the morning...
  60. ncbi A metaproteomic approach gives functional insights into anaerobic digestion
    F Abram
    Microbial Ecology Laboratory, Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland
    J Appl Microbiol 110:1550-60. 2011
    ..The objective of this work was to provide functional evidence of key metabolic pathways important for anaerobic digestion processes through the identification of highly expressed proteins in a mixed anaerobic microbial consortium...
  61. pmc Anaerobic ammonia oxidation in a fertilized paddy soil
    Guibing Zhu
    State Key Laboratory of Environmental Aquatic Quality, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
    ISME J 5:1905-12. 2011
    ..It is estimated that a total loss of 76  g  N  m(-2) per year is linked to anammox in the paddy field...
  62. ncbi Design and development of the ANAEROCHIP microarray for investigation of methanogenic communities
    Ingrid H Franke-Whittle
    Leopold Franzens University, Institute of Microbiology, Technikerstrasse 25 d, 6020, Innsbruck, Austria
    J Microbiol Methods 79:279-88. 2009
    ..7%), Methanosarcina (2.1%), Methanosphaera (1.6%), an uncultured archaeon (1.6%) and Methanothermobacter (1%) were also detected. These results showed the microarray to be a suitable tool for studying methanogenic communities in sludge...
  63. pmc A mutant in the ADH1 gene of Chlamydomonas reinhardtii elicits metabolic restructuring during anaerobiosis
    Leonardo Magneschi
    Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA
    Plant Physiol 158:1293-305. 2012
    ....
  64. ncbi Development of a real-time PCR assay for monitoring anaerobic fungal and cellulolytic bacterial populations within the rumen
    Stuart E Denman
    CSIRO Livestock Industries, St Lucia, QLD, Australia
    FEMS Microbiol Ecol 58:572-82. 2006
    ..succinogenes target between 0 and 12 h after feeding, whereas R. flavefaciens was observed to maintain more or less consistent levels. This is the first report of a real-time PCR assay to estimate the rumen anaerobic fungal population...
  65. pmc Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis
    Shyamasree De Majumdar
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 5:e9448. 2010
    ..DevR regulon genes are powerfully induced in vivo implicating them in bacterial adaptation to host control strategies. A better understanding of DevR function will illumine the way for new strategies to control and treat tuberculosis...
  66. pmc Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C
    Neetu Kumra Taneja
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 5:e10860. 2010
    ..Adaptation to hypoxia and exposure to NO/CO is implemented through the DevRS/DosT two-component system which induces the dormancy regulon...
  67. pmc Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum
    Daniel Amador-Noguez
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    J Bacteriol 192:4452-61. 2010
    ....
  68. pmc Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environments
    Kai Zhuang
    Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    ISME J 5:305-16. 2011
    ..These results show that genome-scale modeling can be a useful tool for predicting microbial interactions in subsurface environments and shows promise for designing bioremediation strategies...
  69. ncbi A new intra-aerobic metabolism in the nitrite-dependent anaerobic methane-oxidizing bacterium Candidatus 'Methylomirabilis oxyfera'
    Ming L Wu
    Department of Microbiology, Radboud University Nijmegen, Institute for Water and Wetland Research, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
    Biochem Soc Trans 39:243-8. 2011
    ..The present mini-review summarizes the current knowledge about this process and the micro-organism responsible for it...
  70. ncbi Nitrate-responsive NarX-NarL represses arginine-mediated induction of the Pseudomonas aeruginosa arginine fermentation arcDABC operon
    Beatrice Benkert
    Institute of Microbiology, Technical University Braunschweig, Spielmannstr 7, D 38106 Braunschweig, Germany
    Microbiology 154:3053-60. 2008
    ..Thus, the anaerobic energy metabolism of P. aeruginosa is coordinated via NarX-NarL activity. In the presence of nitrate the highly efficient denitrification is preferred over the less attractive arginine fermentation...
  71. ncbi A microbial consortium couples anaerobic methane oxidation to denitrification
    Ashna A Raghoebarsing
    Department of Microbiology, Institute for Water and Wetland Research, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Nature 440:918-21. 2006
    ..The detection of relatives of these prokaryotes in different freshwater ecosystems worldwide indicates that the reaction presented here may make a substantial contribution to biological methane and nitrogen cycles...
  72. ncbi Towards the definition of a core of microorganisms involved in anaerobic digestion of sludge
    Delphine Rivière
    CIRSEE Suez Environment, 38 rue du President Wilson, Le Pecq, France
    ISME J 3:700-14. 2009
    ..This comparison of anaerobic digester populations is a first step towards a future understanding of the relationship among biodiversity, operating conditions and digester efficiency...
  73. ncbi Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
    Ming C Tsai
    Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 8:218-32. 2006
    ..tuberculosis...
  74. pmc Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide
    Megan L Falsetta
    Department of Microbiology, University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
    Infect Immun 78:2320-8. 2010
    ..NO treatment partially restores biofilm formation in an aniA::kan insertion mutant, which suggests that N. gonorrhoeae in biofilms may use NO as a substrate for anaerobic growth but prefer nitrite...
  75. pmc Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae
    Eija Rintala
    VTT Technical Research Centre of Finland, P, O, Box 1000, FI 02044 VTT, Finland
    BMC Genomics 10:461. 2009
    ..cerevisiae in glucose-limited chemostat cultivations in anaerobic and aerobic conditions, and with three intermediate (0.5, 1.0 and 2.8% oxygen) levels of oxygen in the feed gas...
  76. pmc Phylogenetic comparison of the methanogenic communities from an acidic, oligotrophic fen and an anaerobic digester treating municipal wastewater sludge
    Lisa M Steinberg
    Department of Civil and Environmental Engineering, The Pennsylvania State University, University Park, PA 16802, USA
    Appl Environ Microbiol 74:6663-71. 2008
    ..Diversity indices for the 16S rRNA gene library of the bog and both mcrA libraries were similar, but these indices indicated much lower diversity in the 16S digester library than in the other three libraries...
  77. ncbi Waste to bioproduct conversion with undefined mixed cultures: the carboxylate platform
    Matthew T Agler
    Department of Biological and Environmental Engineering, Cornell University, Riley Robb Hall, Ithaca, NY 14853, USA
    Trends Biotechnol 29:70-8. 2011
    ....
  78. ncbi Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclists
    J A L Calbet
    Department of Physical Education, University of Las Palmas de Gran Canaria, Canary Islands
    J Appl Physiol (1985) 94:668-76. 2003
    ..The effect of severe acute hypoxia on supramaximal exercise performance depends on training background...
  79. ncbi Investigation by 13C-NMR and tricarboxylic acid (TCA) deletion mutant analysis of pathways for succinate formation in Saccharomyces cerevisiae during anaerobic fermentation
    Carole Camarasa
    UMR Sciences pour l Oenologie, Microbiologie et Technologie des Fermentations, Institut National de la Recherche Agronomique, 2 place Viala, 34060 Montpellier, France
    Microbiology 149:2669-78. 2003
    ..This pathway is the main source of succinate during fermentation, unless glutamate is the sole nitrogen source, in which case the oxidative decarboxylation of 2-oxoglutarate generates additional succinate...
  80. pmc Effect of microaerophilic cell growth conditions on expression of the aerobic (cyoABCDE and cydAB) and anaerobic (narGHJI, frdABCD, and dmsABC) respiratory pathway genes in Escherichia coli
    C P Tseng
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095, USA
    J Bacteriol 178:1094-8. 1996
    ..These two transcriptional regulators coordinate the hierarchial control of respiratory pathway gene expression in E. coli to ensure the optimal use of oxygen in the cell environment...
  81. ncbi Molecular detection of anammox bacteria in terrestrial ecosystems: distribution and diversity
    Sylvia Humbert
    Laboratory of Microbiology, Institute of Biology, University of Neuchatel, Neuchatel, Switzerland
    ISME J 4:450-4. 2010
    ..As opposed to marine water column habitats where Candidatus 'Scalindua' dominates anammox guilds, 'Kuenenia' and 'Brocadia' appear to be the most common representatives in terrestrial environments...
  82. pmc Flexibility in anaerobic metabolism as revealed in a mutant of Chlamydomonas reinhardtii lacking hydrogenase activity
    Alexandra Dubini
    Environmental Science and Engineering Division, Colorado School of Mines, Golden, Colorado 80401, USA
    J Biol Chem 284:7201-13. 2009
    ..important component of this metabolism, and we have compared metabolic and regulatory responses that accompany anaerobiosis in wild-type C...
  83. ncbi Methanosarcina: the rediscovered methanogen for heavy duty biomethanation
    Jo De Vrieze
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    Bioresour Technol 112:1-9. 2012
    ..8-1.0 units and acetate concentrations up to 15,000 mg CODL(-1). The possibilities of Methanosarcina sp. as key organisms in specific types of anaerobic digestion systems are demonstrated in this review...
  84. ncbi Growth characteristic of anaerobic ammonium-oxidizing bacteria in an anaerobic biological filtrated reactor
    Kazuichi Isaka
    Hitachi Plant Engineering and Construction Co, Ltd, Kami Honga 537, Matsudo, Chiba, 271 0064, Japan
    Appl Microbiol Biotechnol 70:47-52. 2006
    ..Maintaining the ideal environment for the growth of anammox bacteria in the ABF reactor might lead to faster growth. This is the first report of the growth rate of anammox bacteria based on the direct counting of anammox bacteria...
  85. ncbi The anaerobic oxidation of ammonium
    M S Jetten
    Kluyver Institute for Biotechnology, TU Delft, The Netherlands
    FEMS Microbiol Rev 22:421-37. 1998
    ..The combination of these partial nitrification and Anammox processes remains a challenge for future application in the removal of ammonium from wastewater with high ammonium concentrations...
  86. ncbi Syntrophaceticus schinkii gen. nov., sp. nov., an anaerobic, syntrophic acetate-oxidizing bacterium isolated from a mesophilic anaerobic filter
    Maria Westerholm
    Department of Microbiology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden
    FEMS Microbiol Lett 309:100-4. 2010
    ..An isolate (strain Esp=JCM 16670) with high 16S rRNA gene sequence identity (99%) to syntrophic acetate-oxidizing Clostridium ultunense was also retrieved from the methanogenic digestor...
  87. pmc The global regulatory hns gene negatively affects adhesion to solid surfaces by anaerobically grown Escherichia coli by modulating expression of flagellar genes and lipopolysaccharide production
    Paolo Landini
    Department of Environmental Microbiology and Molecular Ecotoxicology, Swiss Federal Institute of Environmental Technology EAWAG, CH 8600 Dubendorf, Switzerland
    J Bacteriol 184:1522-9. 2002
    ..Our observations strongly suggest that anoxia is a negative environmental signal for adhesion in E. coli...
  88. pmc Molecular and cellular adaptations of maize to flooding stress
    Chalivendra C Subbaiah
    Department of Crop Sciences, University of Illinois, USA
    Ann Bot 91:119-27. 2003
    Anaerobic treatment dramatically alters the patterns of gene expression in maize (Zea mays L.) seedlings. During anaerobiosis there is an immediate repression of pre-existing protein synthesis, with the concurrent initiation of a ..
  89. ncbi Cell division ring, a new cell division protein and vertical inheritance of a bacterial organelle in anammox planctomycetes
    Laura van Niftrik
    Department of Microbiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Microbiol 73:1009-19. 2009
    ..Electron tomography also revealed that the bacterial organelle was elongated along with the rest of the cell and divided equally among daughter cells during the cell division process...
  90. ncbi Anaerobic ammonium oxidation in a tropical freshwater system (Lake Tanganyika)
    Carsten J Schubert
    Surface Waters Department, Swiss Federal Institute of Aquatic Science and Technology EAWAG, Seestrasse 79, CH 6047 Kastanienbaum, Switzerland
    Environ Microbiol 8:1857-63. 2006
    ..7% similarity). Using the incubation results, a total loss of 0.2 Tg N(2) per year linked to anammox was estimated for the Northern basin of Lake Tanganyika...
  91. pmc Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes
    S B Melville
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095, USA
    Proc Natl Acad Sci U S A 93:1226-31. 1996
    ..A model whereby the FNR protein exists in the cell as a monomer that assembles on the DNA under anaerobic conditions to form a dimer is discussed...
  92. pmc Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    Dieter Worlitzsch
    Institute of General and Environmental Hygiene, University of Tubingen, Tubingen, Germany
    J Clin Invest 109:317-25. 2002
    ..With P. aeruginosa growth in oxygen restricted environments, local hypoxia was exacerbated and frank anaerobiosis, as detected in vivo, resulted...
  93. pmc Metabolic engineering of Escherichia coli for efficient conversion of glycerol to ethanol
    Cong T Trinh
    Department of Chemical Engineering and Materials Science and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St Paul, MN 55108, USA
    Appl Environ Microbiol 75:6696-705. 2009
    ..The performance of the designed strain is predicted by the property space of remaining elementary modes...
  94. pmc Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    Ryan W Honaker
    University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
    Infect Immun 77:3258-63. 2009
    ..Thus, M. tuberculosis has evolved a system whereby it responds to hypoxic conditions in a stepwise fashion as it enters an anaerobic state...
  95. ncbi Methane as fuel for anaerobic microorganisms
    Rudolf K Thauer
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Ann N Y Acad Sci 1125:158-70. 2008
    ..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
  96. pmc Energy conservation via electron-transferring flavoprotein in anaerobic bacteria
    Gloria Herrmann
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, 35032 Marburg, Germany
    J Bacteriol 190:784-91. 2008
  97. ncbi Anammox bacteria: from discovery to application
    J Gijs Kuenen
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    Nat Rev Microbiol 6:320-6. 2008
    ..In this Timeline, Gijs Kuenen recalls the discovery of these unique microorganisms and describes the continuing elucidation of their roles in environmental and industrial microbiology...
  98. ncbi Metabolic engineering of Escherichia coli: increase of NADH availability by overexpressing an NAD(+)-dependent formate dehydrogenase
    Susana J Berríos-Rivera
    Department of Bioengineering and Chemical Engineering, Rice University, Houston, Texas, USA
    Metab Eng 4:217-29. 2002
    ....
  99. pmc Elimination of glycerol production in anaerobic cultures of a Saccharomyces cerevisiae strain engineered to use acetic acid as an electron acceptor
    Víctor Guadalupe Medina
    Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 76:190-5. 2010
    ..Further research should address the kinetic aspects of acetate reduction and the effect of the elimination of glycerol production on cellular robustness (e.g., osmotolerance)...
  100. pmc Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium
    Matthew R Evans
    Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695 7615, USA
    BMC Microbiol 11:58. 2011
    ..The global role of ArcA in E. coli is well characterized; however, little is known about its role in anaerobically grown S. Typhimurium...
  101. pmc Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coli
    Arnim Weber
    Ludwig Maximilians Universitat Munchen, Department Biologie I, Bereich Mikrobiologie, Maria Ward Str 1a, D 80638 München, Germany
    J Bacteriol 188:7165-75. 2006
    ..Only a few proteins were found to be down-regulated upon osmotic stress...

Research Grants35

  1. Symbiosis of E. coli and the Intestinal Microbiota in a Mouse Model
    Tyrrell Conway; Fiscal Year: 2013
    ..e., the food web) and those that create conditions favorable for success of the community (e.g., anaerobiosis)...
  2. Oxygen and Streptococcus mutans Virulence
    Robert A Burne; Fiscal Year: 2010
    ..mutans to air and anaerobiosis will be realized...
  3. ENZYMES OF DINITROGEN REDUCTION
    WILLIAM ORME JOHNSON; Fiscal Year: 1991
    ..The methods used include combinatins of nif genes, large-scale (1000L) culture of E. coli. harboring nif-bearing plasmids, and examination of the purified gene products for enzymic function under rigorous anaerobiosis.
  4. BACTERICIDAL ACTIVITY OF LACTOFERRIN ON ORAL FLORA
    Roland Arnold; Fiscal Year: 1993
    ..will be investigated by determining the nature of damage to target microorganisms determining the effects of anaerobiosis and various radical scavengers in LF cidal activity and by comparing LF effects with those of known radical ..
  5. FUNCTION OF GONOCOCCAL ANAEROBICALLY INDUCED PROTEINS
    Virginia Clark; Fiscal Year: 2007
    ..We have been investigating the regulation of gonococcal gene expression by anaerobiosis, an environmental condition that this pathogen is likely to encounter in vivo in females...
  6. ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    HAROLD DRAKE; Fiscal Year: 1990
    ..Since acetogens and most of their enzymes are extremely sensitive to oxidation, all cultivation, purification, and analytical procedures will be conducted under strict anaerobiosis.
  7. GENETIC ANALYSIS OF THE RECA PROTEIN OF E. COLI
    George Weinstock; Fiscal Year: 1991
    ..following the expression of cea, the gene for colicin E1, which is controlled by RecA, catabolite repression, anaerobiosis, nutrient deprivation, and DNA supercoiling...
  8. ANALYSIS OF THE ANAEROBIC-STRESS RESPONSE IN MAIZE
    Martin Sachs; Fiscal Year: 1992
    ..Anaerobic treatment dramatically alters the pattern of gene expression in maize seedlings. During anaerobiosis there is an immediate repression of pre-existing protein synthesis followed by an induction of gene expression ..
  9. Isolation of New Antibiotics From Soil Microorganisms
    Michael Davis; Fiscal Year: 2004
    ..conditions will be employed to extend the range of types of organisms cultured from these samples, including anaerobiosis and nutrient limited media...
  10. REGULATORY MECHANISMS OF AN INDUCIBLE GENE
    John Walker; Fiscal Year: 1992
    ..alcohol dehydrogenase-1 gene to examine the biochemical factors that are required for gene expression during anaerobiosis. The methods proposed include both in vitro DNA-protein binding assays and in vivo footprinting techniques to ..
  11. GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLI
    Valley J Stewart; Fiscal Year: 2010
    ..Thus, results from the model species E. coli enhance understanding for a broad range of pathogens that significantly impact public health. ..
  12. The Physiology of Oxidative Stress in Escherichia coli
    James Imlay; Fiscal Year: 2006
    ..coli will provide a blueprint for efforts to solve key issues in oxidative stress: obligate anaerobiosis, the killing mechanism of) hagocytes, and endogenous oxidative stress in higher organisms.
  13. MECHANISM OF OXIDATIVE DNA DAMAGE IN MODEL ORGANISMS
    James Imlay; Fiscal Year: 2002
    ..Further, by understanding how metabolic perturbations affect DNA oxidation, we may be able to anticipate the affects of drug therapies upon mutagenesis and cell death. ..
  14. Genetic Control of Tubulin Function in Development
    ELIZABETH RAFF; Fiscal Year: 2005
    ..The primary aim is to determine how transient expression of beta3-tubulin during development modulates the microtubule cytoskeleton in the differentiated cell. ..
  15. ENZYMOLOGY OF ACETOTROPHIC METHANOGENESIS
    JAMES FERRY; Fiscal Year: 2003
    ..The results are expected to contribute not only to a deeper understanding of the acetate fermentation pathway, but more importantly to the broader field of anaerobic microbiology and beyond. ..
  16. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  17. ANAEROBIC EXPRESSION OF FUMARATE REDUCTASE IN E. COLI
    Robert Gunsalus; Fiscal Year: 2008
    ..The Nar and Mode gene families will be identified by microarray analysis. Finally, the physiology of nitrate control will be examined by use of continuous culture methods. [unreadable] [unreadable]..
  18. Stable cationic bacteriochlorins for antimicrobial photodynamic therapy
    JONATHAN LINDSEY; Fiscal Year: 2008
    ..The two best performing bacteriochlorins will then be tested in a mouse model of a potentially lethal wound infection and monitored by bioluminescence imaging. [unreadable] [unreadable] [unreadable]..
  19. Detection of Biofilm Bacteria using GloBac
    Robin Patel; Fiscal Year: 2008
    ..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
  20. Single Cell Analysis of Cross Talk Among Kinase Pathways
    Stefan Kaluz; Fiscal Year: 2008
    ..These studies will provide additional information relating to our understanding of the consequencesof activationof kinase signaling pathwayswith respect to malignant transformation, aggressive tumor growth and survival. ..
  21. Integrating microbial biostimulation and electrolytic aeration to degrade POPs
    Harold D May; Fiscal Year: 2010
    ..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
  22. Characteristics of a putative steroid membrane receptor
    Peter Thomas; Fiscal Year: 2010
    ..However, it is important to establish these points for the mPR. In addition, the studies should provide indications of important regulatory events that might occur in human cells. ..
  23. Mathematical Model of Vascular and Tubular Transport in the Rat Outer Medulla
    AURELIE EDWARDS; Fiscal Year: 2008
    ..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
  24. Environmental Regulation of Staphylococcus epidermidis PIA Synthesis
    GREG SOMERVILLE; Fiscal Year: 2007
    ..The work contained in this proposal is a first step toward inhibiting the formation of this complex sugar, preventing the formation of a bacterial biofilm, and providing physicians a way to treat patients. [unreadable] [unreadable]..
  25. PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
    JONATHAN LINDSEY; Fiscal Year: 2007
    ....
  26. REGULATION OF E COLI CYTOCHROME OXIDASE AND TCA CYCLE
    Robert Gunsalus; Fiscal Year: 2001
    ..coli. These studies should provide a detailed understanding of how the cell coordinates pathways for electron and carbon flow within the cell during transition between oxygen rich and oxygen limiting conditions. ..
  27. SECRETION MECHANISM OF A NOVEL C. RECTUS S-LAYER PROTEIN
    David Kolodrubetz; Fiscal Year: 2002
    ..Finally, the transport mutants will be examined for the possible mis-localization of non-S-layer proteins since there are two reports of type I transport pathways transporting more than one virulence protein. ..
  28. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    ..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
  29. Growth Hormone, IGF-1 and Age-related Pathogenesis
    William Sonntag; Fiscal Year: 2003
    ..In addition, the results will provide important information on the potential risks of administration of growth hormone and IGF-l to the elderly. ..
  30. Probing Microb Comm - Stable Isotope & RNA/DNA Analyses
    James Tiedje; Fiscal Year: 2004
    ..abstract_text> ..
  31. Microbial Degradation of Petroleum Hydrocarbons and PCBs
    HAROLD MAY; Fiscal Year: 2004
    ..It is predicted that this innovative research will lead to the development of new technologies for the co-bioremediation of PCBs and petroleum. ..
  32. MECHANISMS OF REPRODUCTIVE NEUROENDOCRINE TOXICITY
    Peter Thomas; Fiscal Year: 2005
    ..The proposed study will investigate a novel mechanism of PCB neurotoxicity and neuroendocrine toxicity which may also have significance for other neural functions such as those associated with mental health. ..
  33. MECHANISMS AND SIGNIFICANCE OF HYPOXIA INDUCED G1 ARREST
    Lawrence Gardner; Fiscal Year: 2006
    ..abstract_text> ..
  34. Anaerobic Regulatory Pathways in a Periodontopathogen
    David Kolodrubetz; Fiscal Year: 2006
    ..Characterizing undefined, potentially new transcriptional regulatory pathways is important because the proteins involved may serve as targets for future drug development. ..
  35. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Odeniel Sertil; Fiscal Year: 2005
    ..This work will further our knowledge on what might be considered a type of metabolically induced differentiation and could open up a fairly extensive area of inquiry, possibly in antifungal drug development. ..