Genomes and Genes
Summary: The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Publications312 found, 100 shown here
- Spreading dead zones and consequences for marine ecosystemsRobert J Diaz
Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
Science 321:926-9. 2008..Dead zones have now been reported from more than 400 systems, affecting a total area of more than 245,000 square kilometers, and are probably a key stressor on marine ecosystems...
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotesMIKLOS MULLER
The Rockefeller University, New York, New York, USA
Microbiol Mol Biol Rev 76:444-95. 2012..Diversified eukaryotic lineages have retained the same enzymes of anaerobic ATP synthesis, in line with geochemical data indicating low environmental oxygen levels while eukaryotes arose and diversified...
- Nitrite-driven anaerobic methane oxidation by oxygenic bacteriaKatharina F Ettwig
Radboud University Nijmegen, IWWR, Department of Microbiology, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
Nature 464:543-8. 2010..Because nitrogen oxides were already present on early Earth, our finding opens up the possibility that oxygen was available to microbial metabolism before the evolution of oxygenic photosynthesis...
- Deciphering the evolution and metabolism of an anammox bacterium from a community genomeMarc Strous
Department of Microbiology, IWWR, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Nature 440:790-4. 2006..Most significantly, we identified candidate genes responsible for ladderane biosynthesis and biological hydrazine metabolism, and discovered unexpected metabolic versatility...
- Inhibition of anaerobic digestion process: a reviewYe Chen
Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh, NC 27695 7625, USA
Bioresour Technol 99:4044-64. 2008..Co-digestion with other waste, adaptation of microorganisms to inhibitory substances, and incorporation of methods to remove or counteract toxicants before anaerobic digestion can significantly improve the waste treatment efficiency...
- Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesisSang Sun Yoon
Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Dev Cell 3:593-603. 2002..Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa...
- Anaerobic ammonium oxidation by anammox bacteria in the Black SeaMarcel M M Kuypers
Max Planck Institute for Marine Microbiology, Department of Biogeochemistry, Celsiusstrasse 1, 28359 Bremen, Germany
Nature 422:608-11. 2003..The widespread occurrence of ammonium consumption in suboxic marine settings indicates that anammox might be important in the oceanic nitrogen cycle...
- Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptorsG Unden
Institut für Mikrobiologie und Weinforschung, Universitat Mainz, Germany
Biochim Biophys Acta 1320:217-34. 1997..Reductive activation could be achieved by cellular reductants in the absence of O2. In addition, O2 may cause destruction and loss of the FeS cluster. It is not known whether this process is required for regulation of FNR function...
- Molecular mechanism of anaerobic ammonium oxidationBoran Kartal
Institute for Water and Wetland Research, Department of Microbiology, Radboud University Nijmegen, Heyendaalseweg 135, 6525AJ Nijmegen, The Netherlands
Nature 479:127-30. 2011..Furthermore, they reinforce the role of nitric oxide in the evolution of the nitrogen cycle...
- Denitrification as the dominant nitrogen loss process in the Arabian SeaB B Ward
Department of Geosciences, Princeton University, Princeton, New Jersey 08544, USA
Nature 461:78-81. 2009..The large contribution of denitrification to N(2) loss in the Arabian Sea indicates the global significance of denitrification to the oceanic nitrogen budget...
- Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown functionYisheng Kang
Department of Genetics, 425 Henry Mall, University of Wisconsin, Madison, WI 53706, USA
J Bacteriol 187:1135-60. 2005..We suggest that E. coli MG1655 has a larger metabolic potential under anaerobic conditions than has been previously recognized...
- Reverse methanogenesis: testing the hypothesis with environmental genomicsSteven J Hallam
Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA
Science 305:1457-62. 2004..These genome-based observations support previous hypotheses and provide an informed foundation for metabolic modeling of anaerobic methane oxidation...
- Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditionsSvetlana Alexeeva
Laboratory for Microbiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
J Bacteriol 185:204-9. 2003..coli to changes in oxygen availability through the complete range from anaerobiosis to full aerobiosis (S. Alexeeva, B. de Kort, G. Sawers, K. J. Hellingwerf, and M. J. Teixeira de Mattos, J...
- Methanogenic pathway and community structure in a thermophilic anaerobic digestion process of organic solid wasteDaisuke Sasaki
Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
J Biosci Bioeng 111:41-6. 2011..These results imply that the microbial community in the thermophilic degrading process of organic solid waste consists exclusively of unidentified bacteria, which efficiently remove acetate through a non-aceticlastic oxidative pathway...
- Biochemistry and molecular biology of anammox bacteriaMike S M Jetten
Department of Microbiology, IWWR, Faculty of Science, Radboud University of Nijmegen, Toernooiveld 1, Nijmegen, The Netherlands
Crit Rev Biochem Mol Biol 44:65-84. 2009..Application of the anammox process offers an attractive alternative to current wastewater treatment systems for the removal of ammonia-nitrogen. Currently, at least five full scale reactor systems are operational...
- Minimal metabolic engineering of Saccharomyces cerevisiae for efficient anaerobic xylose fermentation: a proof of principleMarko Kuyper
Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
FEMS Yeast Res 4:655-64. 2004..cerevisiae gene products can subsequently be optimised via evolutionary engineering. These results provide a gateway towards commercially viable ethanol production from xylose with S. cerevisiae...
- FNR is a global regulator of virulence and anaerobic metabolism in Salmonella enterica serovar Typhimurium (ATCC 14028s)Ryan C Fink
Department of Microbiology, North Carolina State University, Raleigh, NC 27695 7615, USA
J Bacteriol 189:2262-73. 2007..The inability of the mutant to survive inside macrophages is likely due to its sensitivity to the reactive oxygen species generated by NADPH phagocyte oxidase...
- Anaerobic ammonium-oxidizing bacteria in marine environments: widespread occurrence but low diversityMarkus C Schmid
Department of Microbiology, IWWR, Radboud University Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
Environ Microbiol 9:1476-84. 2007..This study showed the ubiquitous presence of anammox bacteria in anoxic marine ecosystems, supporting previous observations on the importance of anammox for N cycling in marine environments...
- Diversity of ammonium-oxidizing bacteria in a granular sludge anaerobic ammonium-oxidizing (anammox) reactorZhe Xue Quan
Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
Environ Microbiol 10:3130-9. 2008..The partial sequence of hydrazine-oxidizing enzyme (hzo) of dominant AnAOB was also identified using new designed primers. Based on this analysis, we propose to tentatively name this new AnAOB Candidatus'Jettenia asiatica'...
- Production of N(2) through anaerobic ammonium oxidation coupled to nitrate reduction in marine sedimentsBo Thamdrup
Danish Center for Earth System Science, Institute of Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
Appl Environ Microbiol 68:1312-8. 2002..The process can explain ammonium deficiencies in anoxic waters and sediments, and it may contribute significantly to oceanic nitrogen budgets...
- Reprogramming of anaerobic metabolism by the FnrS small RNASylvain Durand
Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
Mol Microbiol 75:1215-31. 2010..We thus suggest that FnrS extends the FNR regulon and increases the efficiency of anaerobic metabolism by repressing the synthesis of enzymes that are not needed under these conditions...
- Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animalsH O Portner
Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
Naturwissenschaften 88:137-46. 2001..As a corollary, capacity limitations at a complex level of organisation, the oxygen delivery system, define thermal tolerance limits before molecular functions become disturbed...
- The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancyRachel L Leistikow
University of Colorado Denver, School of Medicine, Department of Microbiology, P18 9115, 12800 East 19th Avenue, PO Box 6511, Aurora, CO 80045, USA
J Bacteriol 192:1662-70. 2010..tuberculosis to survive in the absence of respiration and to successfully transition rapidly between respiring and nonrespiring conditions without loss of viability...
- Energetics of syntrophic cooperation in methanogenic degradationB Schink
Fakultat fur Biologie, Universitat Konstanz, Germany
Microbiol Mol Biol Rev 61:262-80. 1997..These findings allow us to understand the energy economy of these bacteria on the basis of concepts derived from the bioenergetics of other microorganisms...
- Translational regulation of gene expression by an anaerobically induced small non-coding RNA in Escherichia coliAnders Boysen
Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
J Biol Chem 285:10690-702. 2010....
- Evidence for complete denitrification in a benthic foraminiferNils Risgaard-Petersen
Department of Marine Ecology, National Environmental Research Institute, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
Nature 443:93-6. 2006....
- Plant oxygen sensing is mediated by the N-end rule pathway: a milestone in plant anaerobiosisRashmi Sasidharan
Plant Ecophysiology, Institute of Environmental Biology, Utrecht University, Utrecht, The Netherlands
Plant Cell 23:4173-83. 2011....
- Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in cultureJaiyanth Daniel
University of Central Florida, Biomolecular Science Center, BMS 136, 4000 Central Florida Blvd, Orlando, FL 32816 2364, USA
J Bacteriol 186:5017-30. 2004..Therefore, TG synthesis may be an appropriate target for novel antilatency drugs that can prevent the organism from surviving dormancy and thus assist in the control of tuberculosis...
- The enigma of prokaryotic life in deep hypersaline anoxic basinsPaul W J J van der Wielen
Laboratory of Microbial Ecology, University of Groningen, 9751 NN Haren, Netherlands
Science 307:121-3. 2005..Furthermore, we demonstrated the presence of a unique, metabolically active microbial community in the Discovery basin, which is one of the most extreme terrestrial saline environments known, as it is almost saturated with MgCl2 (5 M)...
- Quantitative proteomics and transcriptomics of anaerobic and aerobic yeast cultures reveals post-transcriptional regulation of key cellular processesMarco J L de Groot
Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
Microbiology 153:3864-78. 2007..S. cerevisiae is therefore an ideal eukaryotic model to study physiological adaptation to anaerobiosis. Recent transcriptome analyses have identified hundreds of genes that are transcriptionally regulated by oxygen ..
- The LysR-type virulence activator AphB regulates the expression of genes in Vibrio cholerae in response to low pH and anaerobiosisGabriela Kovacikova
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
J Bacteriol 192:4181-91. 2010..Further experiments show that the regulation of cadC by AphB in response to low pH and anaerobiosis is mirrored in the heterologous organism Escherichia coli, is independent of the global regulators Fnr and ..
- The NADH oxidase of Streptococcus pneumoniae: its involvement in competence and virulenceI Auzat
Laboratoire d Enzymologie et de Biochimie structurale du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
Mol Microbiol 34:1018-28. 1999..This work establishes, for the first time, the role of O2 in the regulation of pneumococcal transformability and virulence...
- Candidatus "Scalindua brodae", sp. nov., Candidatus "Scalindua wagneri", sp. nov., two new species of anaerobic ammonium oxidizing bacteriaMarkus Schmid
Kluyver Laboratory for Biotechnology, Delft University of Technology, Delft, The Netherlands
Syst Appl Microbiol 26:529-38. 2003..Simultaneously, another new species of the same genus, Candidatus "Scalindua sorokinii", was detected in the water column of the Black Sea, making this genus the most widespread of all anammox bacteria described so far...
- Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulonsKatharina Trunk
Institute of Microbiology, Technische Universitat Braunschweig, Spielmannstr 7, D 38106 Braunschweig, Germany
Environ Microbiol 12:1719-33. 2010..The combination with the experimental data unambiguously identified 130 new members for the Anr and Dnr regulons. The basis for the understanding of two regulons of P. aeruginosa central to biofilm formation and infection is now defined...
- Development of high-rate anaerobic ammonium-oxidizing (anammox) biofilm reactorsIkuo Tsushima
Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060 8628, Japan
Water Res 41:1623-34. 2007..e., simultaneous consumption of NH(4)(+) and NO(2)(-)) of 4.45 g-N of (NH(4)(+)+NO(2)(-))m(-2)day(-1) was detected in the upper 800 microm of the biofilm, which was consistent with the spatial distribution of anammox bacteria...
- Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniaeStella Pesakhov
Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences P O Box 151, Beer Sheva 84101, Israel
Biochim Biophys Acta 1768:590-7. 2007..We suggest that endogenous ROS play an important regulatory role in membrane adaptation, allowing the survival of this anaerobic organism at aerobic environments of the host...
- Hypoxia: a window into Mycobacterium tuberculosis latencyTige R Rustad
Seattle Biomedical Research Institute, Seattle, WA, USA
Cell Microbiol 11:1151-9. 2009..tuberculosis hypoxic responses. We also examine the role of these responses in tuberculosis latency, and identify promising avenues for future studies...
- Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallinD R Sherman
Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 98:7534-9. 2001..When we interrupted expression of this operon by targeted disruption of the upstream gene Rv3134c, the hypoxic regulation of acr was eliminated. These results suggest a possible role for Rv3132c/3133c/3134c in mycobacterial latency...
- Biogeographical distribution of diverse anaerobic ammonium oxidizing (anammox) bacteria in Cape Fear River EstuaryOlivia R Dale
Department of Biology and Marine Biology, University of North Carolina Wilmington, NC 28403, USA
Environ Microbiol 11:1194-207. 2009..Thus, we demonstrated a biogeographical distribution of diverse anammox bacteria influenced by salinity, and provide evidence to link anammox abundance and activities in estuarine sediments...
- Role of the transcriptional activator AppY in regulation of the cyx appA operon of Escherichia coli by anaerobiosis, phosphate starvation, and growth phaseT Atlung
Department of Chemistry and Life Sciences, Roskilde University, Denmark
J Bacteriol 176:5414-22. 1994..The appY mutation eliminated induction of the cyx promoter by anaerobiosis and severely reduced induction of this promoter by phosphate starvation and upon entry into stationary phase ..
- Hypoxia-related processes in the Baltic SeaDaniel J Conley
GeoBiosphere Science Centre, Lund University, SE 223 62 Lund, Sweden
Environ Sci Technol 43:3412-20. 2009..Nutrient load reductions are needed to reduce the extent, severity, and effects of hypoxia...
- Cytochrome cd1-containing nitrite reductase encoding gene nirS as a new functional biomarker for detection of anaerobic ammonium oxidizing (Anammox) bacteriaMeng Li
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China
Environ Sci Technol 45:3547-53. 2011....
- Anaerobic ammonium oxidation (anammox) in different natural ecosystemsBao Lan Hu
Department of Environmental Engineering, Zhejiang University, Hangzhou 310058, China
Biochem Soc Trans 39:1811-6. 2011....
- Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stressesMai Ping Tan
Novartis Institute for Tropical Diseases, Singapore, Singapore
PLoS ONE 5:e13356. 2010..Overall, these data shed light on a new role for nitrate respiration in protecting M. tuberculosis from acidity and reactive nitrogen species, two environmental stresses likely encountered by the pathogen during the course of infection...
- A novel nucleoid protein of Escherichia coli induced under anaerobiotic growth conditionsJun Teramoto
Department of Frontier Bioscience, Hosei University, Koganei, Tokyo 184 8584, Japan
Nucleic Acids Res 38:3605-18. 2010..We then propose that YgiP is a novel nucleoid protein of E. coli under anaerobiosis and propose to rename it Dan (DNA-binding protein under anaerobic conditions).
- Phenotypic repertoire of the FNR regulatory network in Escherichia coliDean A Tolla
Biomedical Engineering Department, One Shields Ave, University of California, Davis, CA 95616, USA
Mol Microbiol 79:149-65. 2011....
- The 'porin-cytochrome' model for microbe-to-mineral electron transferDavid J Richardson
Centre for Molecular and Structural Biochemistry, School of Biological Sciences and School of Chemistry, University of East Anglia, Norwich NR47TJ, UK
Mol Microbiol 85:201-12. 2012....
- Evolution of the metabolic and regulatory networks associated with oxygen availability in two phytopathogenic enterobacteriaLavanya Babujee
Biotechnology Center, University of Wisconsin Madison, WI, USA
BMC Genomics 13:110. 2012..1% glucose) with and without O2...
- Effect of oxygen on the Escherichia coli ArcA and FNR regulation systems and metabolic responsesSagit Shalel Levanon
Department of Biochemistry and Cell Biology, MS 140, 6100 Main St, Rice University, Houston, TX 77005 1892, USA
Biotechnol Bioeng 89:556-64. 2005..The activity of FNR-regulated pathways in the arcA mutant strain is correlated with the high redox potential obtained under microaerobic growth...
- Influence of environmental conditions on methanogenic compositions in anaerobic biogas reactorsDimitar Karakashev
Environment and Resources DTU, Technical University of Denmark, Bygningstorvet, DK 2800 Kongens Lyngby, Denmark
Appl Environ Microbiol 71:331-8. 2005..The impact of the original inoculum used for the reactor start-up was also investigated by assessment of the present population in the reactor. The inoculum population appeared to have no influence on the eventual population...
- Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrationsMatthew D Rolfe
Department of Molecular Biology and Biotechnology, The Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK
Open Biol 2:120091. 2012..Thus, this approach illustrates how systematic examination of regulatory responses in stable and dynamic environments yields new mechanistic insights into adaptive processes...
- Interaction between temperature and ammonia in mesophilic digesters for animal waste treatmentMarcelo L Garcia
Department of Energy, Environmental and Chemical Engineering, Washington University in Saint Louis, Saint Louis, MO 63130, USA
Water Res 43:2373-82. 2009..We extrapolated our data to correlate temperature, ammonia, and methane yield and to hypothesize that the difference between high- and low-ammonia reactors is negligible at the optimum mesophilic temperature of 38 degrees C...
- Detection of active, potentially acetate-oxidizing syntrophs in an anaerobic digester by flux measurement and formyltetrahydrofolate synthetase (FTHFS) expression profilingTomoyuki Hori
Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
Microbiology 157:1980-9. 2011..These transcripts arose from phylogenetically presumed homoacetogens. The results of this study demonstrate that hitherto unidentified phylotypes of homoacetogens are responsible for syntrophic acetate oxidation in an anaerobic digester...
- Methane-consuming archaea revealed by directly coupled isotopic and phylogenetic analysisV J Orphan
Monterey Bay Aquarium Research Institute, Moss Landing, CA 95039, USA
Science 293:484-7. 2001..Our results demonstrate the feasibility of simultaneous determination of the identity and the metabolic activity of naturally occurring microorganisms...
- Host-derived nitrate boosts growth of E. coli in the inflamed gutSebastian E Winter
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA, USA
Science 339:708-11. 2013..Thus, the inflammatory host response selectively enhances the growth of commensal Enterobacteriaceae by generating electron acceptors for anaerobic respiration...
- Effect of biowaste sludge maturation on the diversity of thermophilic bacteria and archaea in an anaerobic reactorM Goberna
Universitat Innsbruck, Institut fur Mikrobiologie, Technikerstrasse 25 d, 6020, Innsbruck, Austria
Appl Environ Microbiol 75:2566-72. 2009..We suggest that the environmental filter imposed by the saline conditions (20 g liter(-1)) selected a stable community of halotolerant and halophilic prokaryotes...
- Oxygen and the spatial structure of microbial communitiesTom Fenchel
Marine Biological Laboratory, University of Copenhagen, Strandpromenaden 5, DK 3000 Helsingør, Denmark
Biol Rev Camb Philos Soc 83:553-69. 2008..Deep lakes undergo thermal stratification in warm waters, resulting in seasonal anaerobiosis below the thermocline, and lakes with a permanent pycnocline often have permanent anoxic deep water...
- Phylogenetic analysis and fluorescence in situ hybridization detection of archaeal and bacterial endosymbionts in the anaerobic ciliate trimyema compressumNaoya Shinzato
Center of Molecular Biosciences, University of the Ryukyus, Nishihara cho, Nakagami gun, Okinawa, 903 0213, Japan
Microb Ecol 54:627-36. 2007..compressum are more complicated than hitherto proposed...
- Effect of time of day on aerobic contribution to the 30-s Wingate test performanceNizar Souissi
Research Unit, Evaluation, Sport, Health, National Centre of Medicine and Science in Sport, Route de l Aéroport, Sfax 3000, Tunisia
Chronobiol Int 24:739-48. 2007..Altogether, these results indicate that the time-of-day effect on performances during the Wingate test is mainly due to better aerobic participation in energy production during the test in the afternoon than in the morning...
- A metaproteomic approach gives functional insights into anaerobic digestionF Abram
Microbial Ecology Laboratory, Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland
J Appl Microbiol 110:1550-60. 2011..The objective of this work was to provide functional evidence of key metabolic pathways important for anaerobic digestion processes through the identification of highly expressed proteins in a mixed anaerobic microbial consortium...
- Anaerobic ammonia oxidation in a fertilized paddy soilGuibing Zhu
State Key Laboratory of Environmental Aquatic Quality, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
ISME J 5:1905-12. 2011..It is estimated that a total loss of 76 g N m(-2) per year is linked to anammox in the paddy field...
- Design and development of the ANAEROCHIP microarray for investigation of methanogenic communitiesIngrid H Franke-Whittle
Leopold Franzens University, Institute of Microbiology, Technikerstrasse 25 d, 6020, Innsbruck, Austria
J Microbiol Methods 79:279-88. 2009..7%), Methanosarcina (2.1%), Methanosphaera (1.6%), an uncultured archaeon (1.6%) and Methanothermobacter (1%) were also detected. These results showed the microarray to be a suitable tool for studying methanogenic communities in sludge...
- A mutant in the ADH1 gene of Chlamydomonas reinhardtii elicits metabolic restructuring during anaerobiosisLeonardo Magneschi
Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305, USA
Plant Physiol 158:1293-305. 2012....
- Development of a real-time PCR assay for monitoring anaerobic fungal and cellulolytic bacterial populations within the rumenStuart E Denman
CSIRO Livestock Industries, St Lucia, QLD, Australia
FEMS Microbiol Ecol 58:572-82. 2006..succinogenes target between 0 and 12 h after feeding, whereas R. flavefaciens was observed to maintain more or less consistent levels. This is the first report of a real-time PCR assay to estimate the rumen anaerobic fungal population...
- Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosisShyamasree De Majumdar
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
PLoS ONE 5:e9448. 2010..DevR regulon genes are powerfully induced in vivo implicating them in bacterial adaptation to host control strategies. A better understanding of DevR function will illumine the way for new strategies to control and treat tuberculosis...
- Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin CNeetu Kumra Taneja
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
PLoS ONE 5:e10860. 2010..Adaptation to hypoxia and exposure to NO/CO is implemented through the DevRS/DosT two-component system which induces the dormancy regulon...
- Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicumDaniel Amador-Noguez
Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
J Bacteriol 192:4452-61. 2010....
- Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environmentsKai Zhuang
Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
ISME J 5:305-16. 2011..These results show that genome-scale modeling can be a useful tool for predicting microbial interactions in subsurface environments and shows promise for designing bioremediation strategies...
- A new intra-aerobic metabolism in the nitrite-dependent anaerobic methane-oxidizing bacterium Candidatus 'Methylomirabilis oxyfera'Ming L Wu
Department of Microbiology, Radboud University Nijmegen, Institute for Water and Wetland Research, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
Biochem Soc Trans 39:243-8. 2011..The present mini-review summarizes the current knowledge about this process and the micro-organism responsible for it...
- Nitrate-responsive NarX-NarL represses arginine-mediated induction of the Pseudomonas aeruginosa arginine fermentation arcDABC operonBeatrice Benkert
Institute of Microbiology, Technical University Braunschweig, Spielmannstr 7, D 38106 Braunschweig, Germany
Microbiology 154:3053-60. 2008..Thus, the anaerobic energy metabolism of P. aeruginosa is coordinated via NarX-NarL activity. In the presence of nitrate the highly efficient denitrification is preferred over the less attractive arginine fermentation...
- A microbial consortium couples anaerobic methane oxidation to denitrificationAshna A Raghoebarsing
Department of Microbiology, Institute for Water and Wetland Research, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Nature 440:918-21. 2006..The detection of relatives of these prokaryotes in different freshwater ecosystems worldwide indicates that the reaction presented here may make a substantial contribution to biological methane and nitrogen cycles...
- Towards the definition of a core of microorganisms involved in anaerobic digestion of sludgeDelphine Rivière
CIRSEE Suez Environment, 38 rue du President Wilson, Le Pecq, France
ISME J 3:700-14. 2009..This comparison of anaerobic digester populations is a first step towards a future understanding of the relationship among biodiversity, operating conditions and digester efficiency...
- Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tensionMing C Tsai
Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Cell Microbiol 8:218-32. 2006..tuberculosis...
- Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxideMegan L Falsetta
Department of Microbiology, University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
Infect Immun 78:2320-8. 2010..NO treatment partially restores biofilm formation in an aniA::kan insertion mutant, which suggests that N. gonorrhoeae in biofilms may use NO as a substrate for anaerobic growth but prefer nitrite...
- Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiaeEija Rintala
VTT Technical Research Centre of Finland, P, O, Box 1000, FI 02044 VTT, Finland
BMC Genomics 10:461. 2009..cerevisiae in glucose-limited chemostat cultivations in anaerobic and aerobic conditions, and with three intermediate (0.5, 1.0 and 2.8% oxygen) levels of oxygen in the feed gas...
- Phylogenetic comparison of the methanogenic communities from an acidic, oligotrophic fen and an anaerobic digester treating municipal wastewater sludgeLisa M Steinberg
Department of Civil and Environmental Engineering, The Pennsylvania State University, University Park, PA 16802, USA
Appl Environ Microbiol 74:6663-71. 2008..Diversity indices for the 16S rRNA gene library of the bog and both mcrA libraries were similar, but these indices indicated much lower diversity in the 16S digester library than in the other three libraries...
- Waste to bioproduct conversion with undefined mixed cultures: the carboxylate platformMatthew T Agler
Department of Biological and Environmental Engineering, Cornell University, Riley Robb Hall, Ithaca, NY 14853, USA
Trends Biotechnol 29:70-8. 2011....
- Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclistsJ A L Calbet
Department of Physical Education, University of Las Palmas de Gran Canaria, Canary Islands
J Appl Physiol (1985) 94:668-76. 2003..The effect of severe acute hypoxia on supramaximal exercise performance depends on training background...
- Investigation by 13C-NMR and tricarboxylic acid (TCA) deletion mutant analysis of pathways for succinate formation in Saccharomyces cerevisiae during anaerobic fermentationCarole Camarasa
UMR Sciences pour l Oenologie, Microbiologie et Technologie des Fermentations, Institut National de la Recherche Agronomique, 2 place Viala, 34060 Montpellier, France
Microbiology 149:2669-78. 2003..This pathway is the main source of succinate during fermentation, unless glutamate is the sole nitrogen source, in which case the oxidative decarboxylation of 2-oxoglutarate generates additional succinate...
- Effect of microaerophilic cell growth conditions on expression of the aerobic (cyoABCDE and cydAB) and anaerobic (narGHJI, frdABCD, and dmsABC) respiratory pathway genes in Escherichia coliC P Tseng
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095, USA
J Bacteriol 178:1094-8. 1996..These two transcriptional regulators coordinate the hierarchial control of respiratory pathway gene expression in E. coli to ensure the optimal use of oxygen in the cell environment...
- Molecular detection of anammox bacteria in terrestrial ecosystems: distribution and diversitySylvia Humbert
Laboratory of Microbiology, Institute of Biology, University of Neuchatel, Neuchatel, Switzerland
ISME J 4:450-4. 2010..As opposed to marine water column habitats where Candidatus 'Scalindua' dominates anammox guilds, 'Kuenenia' and 'Brocadia' appear to be the most common representatives in terrestrial environments...
- Flexibility in anaerobic metabolism as revealed in a mutant of Chlamydomonas reinhardtii lacking hydrogenase activityAlexandra Dubini
Environmental Science and Engineering Division, Colorado School of Mines, Golden, Colorado 80401, USA
J Biol Chem 284:7201-13. 2009..important component of this metabolism, and we have compared metabolic and regulatory responses that accompany anaerobiosis in wild-type C...
- Methanosarcina: the rediscovered methanogen for heavy duty biomethanationJo De Vrieze
Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
Bioresour Technol 112:1-9. 2012..8-1.0 units and acetate concentrations up to 15,000 mg CODL(-1). The possibilities of Methanosarcina sp. as key organisms in specific types of anaerobic digestion systems are demonstrated in this review...
- Growth characteristic of anaerobic ammonium-oxidizing bacteria in an anaerobic biological filtrated reactorKazuichi Isaka
Hitachi Plant Engineering and Construction Co, Ltd, Kami Honga 537, Matsudo, Chiba, 271 0064, Japan
Appl Microbiol Biotechnol 70:47-52. 2006..Maintaining the ideal environment for the growth of anammox bacteria in the ABF reactor might lead to faster growth. This is the first report of the growth rate of anammox bacteria based on the direct counting of anammox bacteria...
- The anaerobic oxidation of ammoniumM S Jetten
Kluyver Institute for Biotechnology, TU Delft, The Netherlands
FEMS Microbiol Rev 22:421-37. 1998..The combination of these partial nitrification and Anammox processes remains a challenge for future application in the removal of ammonium from wastewater with high ammonium concentrations...
- Syntrophaceticus schinkii gen. nov., sp. nov., an anaerobic, syntrophic acetate-oxidizing bacterium isolated from a mesophilic anaerobic filterMaria Westerholm
Department of Microbiology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden
FEMS Microbiol Lett 309:100-4. 2010..An isolate (strain Esp=JCM 16670) with high 16S rRNA gene sequence identity (99%) to syntrophic acetate-oxidizing Clostridium ultunense was also retrieved from the methanogenic digestor...
- The global regulatory hns gene negatively affects adhesion to solid surfaces by anaerobically grown Escherichia coli by modulating expression of flagellar genes and lipopolysaccharide productionPaolo Landini
Department of Environmental Microbiology and Molecular Ecotoxicology, Swiss Federal Institute of Environmental Technology EAWAG, CH 8600 Dubendorf, Switzerland
J Bacteriol 184:1522-9. 2002..Our observations strongly suggest that anoxia is a negative environmental signal for adhesion in E. coli...
- Molecular and cellular adaptations of maize to flooding stressChalivendra C Subbaiah
Department of Crop Sciences, University of Illinois, USA
Ann Bot 91:119-27. 2003Anaerobic treatment dramatically alters the patterns of gene expression in maize (Zea mays L.) seedlings. During anaerobiosis there is an immediate repression of pre-existing protein synthesis, with the concurrent initiation of a ..
- Cell division ring, a new cell division protein and vertical inheritance of a bacterial organelle in anammox planctomycetesLaura van Niftrik
Department of Microbiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, Nijmegen, The Netherlands
Mol Microbiol 73:1009-19. 2009..Electron tomography also revealed that the bacterial organelle was elongated along with the rest of the cell and divided equally among daughter cells during the cell division process...
- Anaerobic ammonium oxidation in a tropical freshwater system (Lake Tanganyika)Carsten J Schubert
Surface Waters Department, Swiss Federal Institute of Aquatic Science and Technology EAWAG, Seestrasse 79, CH 6047 Kastanienbaum, Switzerland
Environ Microbiol 8:1857-63. 2006..7% similarity). Using the incubation results, a total loss of 0.2 Tg N(2) per year linked to anammox was estimated for the Northern basin of Lake Tanganyika...
- Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genesS B Melville
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095, USA
Proc Natl Acad Sci U S A 93:1226-31. 1996..A model whereby the FNR protein exists in the cell as a monomer that assembles on the DNA under anaerobic conditions to form a dimer is discussed...
- Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patientsDieter Worlitzsch
Institute of General and Environmental Hygiene, University of Tubingen, Tubingen, Germany
J Clin Invest 109:317-25. 2002..With P. aeruginosa growth in oxygen restricted environments, local hypoxia was exacerbated and frank anaerobiosis, as detected in vivo, resulted...
- Metabolic engineering of Escherichia coli for efficient conversion of glycerol to ethanolCong T Trinh
Department of Chemical Engineering and Materials Science and BioTechnology Institute, University of Minnesota, 240 Gortner Laboratory, 1479 Gortner Ave, St Paul, MN 55108, USA
Appl Environ Microbiol 75:6696-705. 2009..The performance of the designed strain is predicted by the property space of remaining elementary modes...
- Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancyRyan W Honaker
University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
Infect Immun 77:3258-63. 2009..Thus, M. tuberculosis has evolved a system whereby it responds to hypoxic conditions in a stepwise fashion as it enters an anaerobic state...
- Methane as fuel for anaerobic microorganismsRudolf K Thauer
Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
Ann N Y Acad Sci 1125:158-70. 2008..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
- Energy conservation via electron-transferring flavoprotein in anaerobic bacteriaGloria Herrmann
Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, 35032 Marburg, Germany
J Bacteriol 190:784-91. 2008
- Anammox bacteria: from discovery to applicationJ Gijs Kuenen
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
Nat Rev Microbiol 6:320-6. 2008..In this Timeline, Gijs Kuenen recalls the discovery of these unique microorganisms and describes the continuing elucidation of their roles in environmental and industrial microbiology...
- Metabolic engineering of Escherichia coli: increase of NADH availability by overexpressing an NAD(+)-dependent formate dehydrogenaseSusana J Berríos-Rivera
Department of Bioengineering and Chemical Engineering, Rice University, Houston, Texas, USA
Metab Eng 4:217-29. 2002....
- Elimination of glycerol production in anaerobic cultures of a Saccharomyces cerevisiae strain engineered to use acetic acid as an electron acceptorVíctor Guadalupe Medina
Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, 2628 BC Delft, The Netherlands
Appl Environ Microbiol 76:190-5. 2010..Further research should address the kinetic aspects of acetate reduction and the effect of the elimination of glycerol production on cellular robustness (e.g., osmotolerance)...
- Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. TyphimuriumMatthew R Evans
Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695 7615, USA
BMC Microbiol 11:58. 2011..The global role of ArcA in E. coli is well characterized; however, little is known about its role in anaerobically grown S. Typhimurium...
- Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coliArnim Weber
Ludwig Maximilians Universitat Munchen, Department Biologie I, Bereich Mikrobiologie, Maria Ward Str 1a, D 80638 München, Germany
J Bacteriol 188:7165-75. 2006..Only a few proteins were found to be down-regulated upon osmotic stress...
- Symbiosis of E. coli and the Intestinal Microbiota in a Mouse ModelTyrrell Conway; Fiscal Year: 2013..e., the food web) and those that create conditions favorable for success of the community (e.g., anaerobiosis)...
- Oxygen and Streptococcus mutans VirulenceRobert A Burne; Fiscal Year: 2010..mutans to air and anaerobiosis will be realized...
- ENZYMES OF DINITROGEN REDUCTIONWILLIAM ORME JOHNSON; Fiscal Year: 1991..The methods used include combinatins of nif genes, large-scale (1000L) culture of E. coli. harboring nif-bearing plasmids, and examination of the purified gene products for enzymic function under rigorous anaerobiosis.
- BACTERICIDAL ACTIVITY OF LACTOFERRIN ON ORAL FLORARoland Arnold; Fiscal Year: 1993..will be investigated by determining the nature of damage to target microorganisms determining the effects of anaerobiosis and various radical scavengers in LF cidal activity and by comparing LF effects with those of known radical ..
- FUNCTION OF GONOCOCCAL ANAEROBICALLY INDUCED PROTEINSVirginia Clark; Fiscal Year: 2007..We have been investigating the regulation of gonococcal gene expression by anaerobiosis, an environmental condition that this pathogen is likely to encounter in vivo in females...
- ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKELHAROLD DRAKE; Fiscal Year: 1990..Since acetogens and most of their enzymes are extremely sensitive to oxidation, all cultivation, purification, and analytical procedures will be conducted under strict anaerobiosis.
- GENETIC ANALYSIS OF THE RECA PROTEIN OF E. COLIGeorge Weinstock; Fiscal Year: 1991..following the expression of cea, the gene for colicin E1, which is controlled by RecA, catabolite repression, anaerobiosis, nutrient deprivation, and DNA supercoiling...
- ANALYSIS OF THE ANAEROBIC-STRESS RESPONSE IN MAIZEMartin Sachs; Fiscal Year: 1992..Anaerobic treatment dramatically alters the pattern of gene expression in maize seedlings. During anaerobiosis there is an immediate repression of pre-existing protein synthesis followed by an induction of gene expression ..
- Isolation of New Antibiotics From Soil MicroorganismsMichael Davis; Fiscal Year: 2004..conditions will be employed to extend the range of types of organisms cultured from these samples, including anaerobiosis and nutrient limited media...
- REGULATORY MECHANISMS OF AN INDUCIBLE GENEJohn Walker; Fiscal Year: 1992..alcohol dehydrogenase-1 gene to examine the biochemical factors that are required for gene expression during anaerobiosis. The methods proposed include both in vitro DNA-protein binding assays and in vivo footprinting techniques to ..
- GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLIValley J Stewart; Fiscal Year: 2010..Thus, results from the model species E. coli enhance understanding for a broad range of pathogens that significantly impact public health. ..
- The Physiology of Oxidative Stress in Escherichia coliJames Imlay; Fiscal Year: 2006..coli will provide a blueprint for efforts to solve key issues in oxidative stress: obligate anaerobiosis, the killing mechanism of) hagocytes, and endogenous oxidative stress in higher organisms.
- MECHANISM OF OXIDATIVE DNA DAMAGE IN MODEL ORGANISMSJames Imlay; Fiscal Year: 2002..Further, by understanding how metabolic perturbations affect DNA oxidation, we may be able to anticipate the affects of drug therapies upon mutagenesis and cell death. ..
- Genetic Control of Tubulin Function in DevelopmentELIZABETH RAFF; Fiscal Year: 2005..The primary aim is to determine how transient expression of beta3-tubulin during development modulates the microtubule cytoskeleton in the differentiated cell. ..
- ENZYMOLOGY OF ACETOTROPHIC METHANOGENESISJAMES FERRY; Fiscal Year: 2003..The results are expected to contribute not only to a deeper understanding of the acetate fermentation pathway, but more importantly to the broader field of anaerobic microbiology and beyond. ..
- Enhancement of antimicrobics by electrical currentRobin Patel; Fiscal Year: 2007..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
- ANAEROBIC EXPRESSION OF FUMARATE REDUCTASE IN E. COLIRobert Gunsalus; Fiscal Year: 2008..The Nar and Mode gene families will be identified by microarray analysis. Finally, the physiology of nitrate control will be examined by use of continuous culture methods. [unreadable] [unreadable]..
- Stable cationic bacteriochlorins for antimicrobial photodynamic therapyJONATHAN LINDSEY; Fiscal Year: 2008..The two best performing bacteriochlorins will then be tested in a mouse model of a potentially lethal wound infection and monitored by bioluminescence imaging. [unreadable] [unreadable] [unreadable]..
- Detection of Biofilm Bacteria using GloBacRobin Patel; Fiscal Year: 2008..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
- Single Cell Analysis of Cross Talk Among Kinase PathwaysStefan Kaluz; Fiscal Year: 2008..These studies will provide additional information relating to our understanding of the consequencesof activationof kinase signaling pathwayswith respect to malignant transformation, aggressive tumor growth and survival. ..
- Integrating microbial biostimulation and electrolytic aeration to degrade POPsHarold D May; Fiscal Year: 2010..Implementation of a tractable in situ detoxification process to organohalide impacted sites will mitigate exposure to the food chain and subsequent exposure risks to the general public. ..
- Characteristics of a putative steroid membrane receptorPeter Thomas; Fiscal Year: 2010..However, it is important to establish these points for the mPR. In addition, the studies should provide indications of important regulatory events that might occur in human cells. ..
- Mathematical Model of Vascular and Tubular Transport in the Rat Outer MedullaAURELIE EDWARDS; Fiscal Year: 2008..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
- Environmental Regulation of Staphylococcus epidermidis PIA SynthesisGREG SOMERVILLE; Fiscal Year: 2007..The work contained in this proposal is a first step toward inhibiting the formation of this complex sugar, preventing the formation of a bacterial biofilm, and providing physicians a way to treat patients. [unreadable] [unreadable]..
- PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONSJONATHAN LINDSEY; Fiscal Year: 2007....
- REGULATION OF E COLI CYTOCHROME OXIDASE AND TCA CYCLERobert Gunsalus; Fiscal Year: 2001..coli. These studies should provide a detailed understanding of how the cell coordinates pathways for electron and carbon flow within the cell during transition between oxygen rich and oxygen limiting conditions. ..
- SECRETION MECHANISM OF A NOVEL C. RECTUS S-LAYER PROTEINDavid Kolodrubetz; Fiscal Year: 2002..Finally, the transport mutants will be examined for the possible mis-localization of non-S-layer proteins since there are two reports of type I transport pathways transporting more than one virulence protein. ..
- HUMAN RETROVIRUS-5 AND ARTHRITISRobin Patel; Fiscal Year: 2002..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
- Growth Hormone, IGF-1 and Age-related PathogenesisWilliam Sonntag; Fiscal Year: 2003..In addition, the results will provide important information on the potential risks of administration of growth hormone and IGF-l to the elderly. ..
- Probing Microb Comm - Stable Isotope & RNA/DNA AnalysesJames Tiedje; Fiscal Year: 2004..abstract_text> ..
- Microbial Degradation of Petroleum Hydrocarbons and PCBsHAROLD MAY; Fiscal Year: 2004..It is predicted that this innovative research will lead to the development of new technologies for the co-bioremediation of PCBs and petroleum. ..
- MECHANISMS OF REPRODUCTIVE NEUROENDOCRINE TOXICITYPeter Thomas; Fiscal Year: 2005..The proposed study will investigate a novel mechanism of PCB neurotoxicity and neuroendocrine toxicity which may also have significance for other neural functions such as those associated with mental health. ..
- MECHANISMS AND SIGNIFICANCE OF HYPOXIA INDUCED G1 ARRESTLawrence Gardner; Fiscal Year: 2006..abstract_text> ..
- Anaerobic Regulatory Pathways in a PeriodontopathogenDavid Kolodrubetz; Fiscal Year: 2006..Characterizing undefined, potentially new transcriptional regulatory pathways is important because the proteins involved may serve as targets for future drug development. ..
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMOdeniel Sertil; Fiscal Year: 2005..This work will further our knowledge on what might be considered a type of metabolically induced differentiation and could open up a fairly extensive area of inquiry, possibly in antifungal drug development. ..