Genomes and Genes
Summary: One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the BLADDER.
Publications357 found, 100 shown here
- Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4K Stark
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
Nature 372:679-83. 1994..In response to a signal from the ureter, mesenchymal cells condense, aggregate into pretubular clusters and undergo an epithelial conversion generating a ..
- Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney developmentFrank Costantini
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 18:698-712. 2010..In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas...
- Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney developmentArindam Majumdar
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 130:3175-85. 2003....
- SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formationXuguang Nie
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
Development 137:755-65. 2010Dysfunction of the ureter often leads to urine flow impairment from the kidney to the bladder, causing dilation of the ureter and/or renal pelvis...
- Interstitial cell of Cajal-like cells in the upper urinary tractR J Lang
Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
J Cell Mol Med 9:543-56. 2005..SMC after pyeloureteral/ureteral obstruction or surgery, ICC-like cell pacemaking provides a compensatory mechanism allowing the ureter to maintain rudimentary peristaltic waves and movement of urine from the pyelon towards the bladder.
- Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney developmentSunder Sims-Lucas
Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
Dev Dyn 240:240-9. 2011..Beyond E12.5, Fgfr1(Mes-/-)Fgfr2IIIc-/- mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development...
- Ureteric branching morphogenesis in BMP4 heterozygous mutant miceJason E Cain
Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Victoria, Australia
J Anat 209:745-55. 2006..In addition, reduced endogenous levels of BMP4 do not alter the inhibitory effects of exogenous BMP4 on ureteric branching or amplification of normal renal asymmetry...
- Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma CollaborationVitaly Margulis
Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 115:1224-33. 2009..A large series of patients treated with radical nephroureterectomy for UTUC were studied, and variables associated with poor prognosis were identified...
- Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signalingAndrea Brenner-Anantharam
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
Development 134:1967-75. 2007..tract morphogenesis requires the sub-division of the ureteric bud (UB) into the intra-renal collecting system and ureter, two tissues with unique structural and functional properties...
- Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouseInga J Murawski
Department of Pediatrics, Montreal Children s Hospital, McGill University, Quebec, Canada
Am J Physiol Renal Physiol 293:F1736-45. 2007..In VUR, urine flows retrogradely from the bladder to the ureter and is associated with urinary tract infections, hypertension, and renal failure...
- Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4Xavier Caubit
Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, Marseille, France
Development 135:3301-10. 2008..Ex vivo, the spontaneous contractions that occurred in proximal segments of wild-type embryonic ureter explants were absent in Tshz3 mutant ureters...
- Renal abnormalities and their developmental originAndreas Schedl
INSERM, U636, F 06108 Nice, France
Nat Rev Genet 8:791-802. 2007..Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how the kidney develops...
- Tbx18 regulates the development of the ureteral mesenchymeRannar Airik
Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
J Clin Invest 116:663-74. 2006..They are often caused by physical obstruction or by functional impairment of the peristaltic machinery of the ureter. The underlying molecular and cellular defects are, however, poorly understood...
- Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney developmentSusan M Kiefer
John Cochran Veterans Affairs Medical Center, St Louis, MO 63106, USA
Development 137:3099-106. 2010..expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...
- Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidneyR Brandenberger
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 154:447-58. 2001..The approaches used here should be generally useful for characterizing the interactions of novel extracellular matrix proteins identified through genomic sequencing projects...
- Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUTIekuni Ichikawa
Department of Pediatrics, Vanderbilt University Medical Center, MCN C4204, 21st and Garland Avenue, Nashville, TN 37232 2584, USA
Kidney Int 61:889-98. 2002Ectopic budding of the ureter from the Wolffian duct is the first ontogenic misstep that leads to many-if not all-congenital anomalies of the kidney and urinary tract (CAKUT)...
- The modified sting procedure to correct vesicoureteral reflux: improved results with submucosal implantation within the intramural ureterAndrew J Kirsch
Department of Pediatric Urology, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
J Urol 171:2413-6. 2004..We describe a modification of the technique used for implantation that has significantly improved our results...
- Regulation of BMP7 expression during kidney developmentR E Godin
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 125:3473-82. 1998..By contrast, BMP7 expression in the metanephric mesenchyme is dependent on proteoglycans and possibly Wnt signaling...
- Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiationJamie A Davies
The Department of Anatomy, Edinburgh University, Edinburgh, UK
Hum Mol Genet 13:235-46. 2004....
- Creation of ureteropelvic junction obstruction and its correction by chemical glue-assisted laparoscopic dismembered pyeloplastyAllen W Chiu
Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
J Endourol 17:23-8. 2003..We established a porcine model of ureteropelvic junction (UPJ) obstruction using a laparoscopic technique and assessed the outcome of standard suture-assisted and chemical glue-assisted laparoscopic pyeloplasty...
- Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidneyVidya K Nagalakshmi
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Kidney Int 79:317-30. 2011..Furthermore, an understanding of miRNA action may provide new insights into the etiology and pathogenesis of renal cyst-based kidney disease...
- Angiotensin II stimulates in vitro branching morphogenesis of the isolated ureteric budRenfang Song
Division of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Mech Dev 128:359-67. 2011..We conclude that Ang II-regulated genes in the iUB may be important mediators of Ang II-induced UB branching. We hypothesize that Ang II-dependent cell movements play an important role in UB branching morphogenesis...
- Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchymeRannar Airik
Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
Hum Mol Genet 19:4918-29. 2010Congenital ureter anomalies, including hydroureter, affect up to 1% of the newborn children. Despite the prevalence of these developmental abnormalities in young children, the underlying molecular causes are only poorly understood...
- Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatasesNoriko Uetani
Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Clin Invest 119:924-35. 2009Congenital anomalies affecting the ureter-bladder junction are frequent in newborns and are often associated with other developmental defects...
- The effects of ureteral obstruction on Cajal-like cells in ratsBaris Kuzgunbay
Department of Urology, Cukurova University, Adana 01330, Turkey
J Pediatr Urol 5:269-73. 2009..To determine the changes in number and morphology of interstitial cells of Cajal (ICC)-like cells (ICC-LC) at the ureteropelvic junction (UPJ) of rats after experimental distal ureteral obstruction...
- Novel technique for management of distal ureter and en block resection of bladder cuff during hand-assisted laparoscopic nephroureterectomyItay Y Vardi
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Urology 67:89-92. 2006..our experience with a novel flexible cystoscopic approach to excise the en block bladder cuff and juxtavesical ureter during hand-assisted laparoscopic nephroureterectomy...
- Dynamic hydrodistention classification of the ureter and the double hit method to correct vesicoureteral refluxWolfgang H Cerwinka
Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta 30342, USA
Arch Esp Urol 61:882-7. 2008The objective of this monograph is to familiarize the reader with dynamic hydrodistention classification of the ureter and Hydrodistention Implantation Technique (HIT) methodology for the endoscopic correction of vesicoureteral reflux (..
- A sealed laparoscopic nephroureterectomy: a new techniqueAlexander Tsivian
Department of Urologic Surgery, Wolfson Medical Center, Holon, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Eur Urol 52:1015-9. 2007..To describe a purely laparoscopic nephroureterectomy approach that avoids the disadvantages of transurethral bladder cuff excision and open/laparoscopic distal ureterectomy using the EndoGIA...
- Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesisShao Ling Zhang
University of Montreal, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon Masson, Montreal, Quebec, Canada
J Am Soc Nephrol 18:2105-15. 2007..Taken together, these data demonstrate that high glucose alters UB branching morphogenesis. This occurs, at least in part, via reactive oxygen species generation, activation of Akt signaling, and upregulation of Pax-2 gene expression...
- Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoceptors in human ureterHyoung Keun Park
Department of Urology, College of Medicine, Dongguk University, Gyeongju, Republic of Korea
Urol Res 35:325-9. 2007..subtypes was examined by immunohistochemistry using subtype selective antibodies in proximal, mid and distal ureter. Ureter samples were obtained from pathological specimens of nephroureterectomy...
- Laparoscopic ureteroneocystostomy and psoas hitch for post-hysterectomy ureterovaginal fistulaPranjal Modi
Department of Urology and Transplantation Surgery, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India
J Urol 180:615-7. 2008..We assessed the results of laparoscopic ureteroneocystostomy with a psoas hitch for iatrogenic lower ureteral injuries leading to a ureterovaginal fistula...
- Management of ureteric injuries during gynecological operations: 10 years experiencePanos Sakellariou
Department of Urology, Alexandra Maternity Hospital, Athens, Greece
Eur J Obstet Gynecol Reprod Biol 101:179-84. 2002..To present our 10 years experience in the management of ureteric injuries occurring during gynecological surgery...
- The expression of Cajal cells at the obstruction site of congenital pelviureteric junction obstruction and quantitative image analysisXinghai Yang
Department of Pediatric Surgery, Hubei Women and Children s Hospital, Wuhan 430070, People s Republic of China
J Pediatr Surg 44:2339-42. 2009..The study aimed to analyze the expression and significance of interstitial cells of Cajal (ICC) at the obstruction site of congenital pelviureteric junction obstruction (PUJO)...
- Sprouty1 is a critical regulator of GDNF/RET-mediated kidney inductionM Albert Basson
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
Dev Cell 8:229-39. 2005..These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations...
- Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstructionValeria Solari
Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
J Urol 170:2420-2. 2003Peristaltic contractions in the upper urinary tract serve to move urine from the kidney through the ureter to the bladder. Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children...
- Functional obstruction: the renal pelvis rulesCathy Mendelsohn
Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 113:957-9. 2004..New animal models reveal molecular pathways important for peristalsis and point to the central role of the renal pelvis in urine transport...
- Examination of alpha 1 adrenoceptor subtypes in the human ureterYasunori Itoh
Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
Int J Urol 14:749-53. 2007..This study was carried out to characterize the alpha 1 adrenoceptors (AR) subtype gene and protein expression in the proximal, medial, and distal regions of the human ureter with the aim of facilitating stone expulsion.
- Long-term comparative outcomes of open versus laparoscopic nephroureterectomy for upper urinary tract urothelial-cell carcinoma after a median follow-up of 13 years*Grant D Stewart
Edinburgh Urological Cancer Group, University of Edinburgh, Department of Urology, Western General Hospital, Edinburgh, United Kingdom
J Endourol 25:1329-35. 2011..The longest published follow-up of LNU is 7 years. We report outcomes for patients having surgery ≥10 years ago...
- Cajal-like cells in the human upper urinary tractRoman Metzger
Department of Pediatric Surgery, University of Munich, Germany
J Urol 172:769-72. 2004..It is still unknown if ICCs also occur in the human upper urinary tract. Since these cells express and are marked by the c-kit receptor CD117, we investigated its occurrence and distribution along the human upper urinary tract...
- Cajal-like cells in the upper urinary tract: comparative study in various speciesRoman Metzger
Department of Pediatric Surgery, University of Munich, Munich, Germany
Pediatr Surg Int 21:169-74. 2005..Normal proximal, middle, and distal ureter segments were analyzed in rodents, carnivores, porcines, cow, and humans...
- Surgical treatment of ureteral obstruction from endometriosis: our experience with thirteen casesAlessandro Antonelli
Clinica Urologica, Spedali Civili di Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy
Int Urogynecol J Pelvic Floor Dysfunct 15:407-12; discussion 412. 2004..results as extended ureteral resection can be performed and continuity of the urinary tract can be restored without resorting to the distal pelvic ureter, which is often affected by the disease besides being more subject to relapses.
- Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal developmentRandy S Levinson
Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Development 132:529-39. 2005....
- Laparoscopic mid sagittal hemicystectomy and bladder reconstruction with small intestinal submucosa and reimplantation of ureter into small intestinal submucosa: 1-year followupJaime Landman
Department of Pathology, Washington University School of Medicine, St Louis, Missouri
J Urol 171:2450-5. 2004..We evaluated the long-term results of laparoscopic hemicystectomy and bladder replacement with small intestinal submucosa (SIS) with ureteral reimplantation into the SIS material...
- Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakersRichard J Lang
Department of Physiology, Monash University, Clayton 3800, Australia
J Physiol 576:695-705. 2006....
- Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUTYoichi Miyazaki
Departments of Pediatrics and Medicine, Vanderbilt University Medical Center Nashville, TN, USA
Pediatr Int 45:598-604. 2003Ectopic budding of the initial ureter from the Wolffian duct is the first ontogenic misstep that leads to many congenital anomalies of the kidney and urinary tract (CAKUT)...
- Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud developmentA Schuchardt
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, NY 10032, USA
Development 122:1919-29. 1996..This factor appears to stimulate the initial evagination of the ureteric bud from the Wolffian duct, as well as its subsequent growth and branching...
- 1-step removal of encrusted retained ureteral stentsRaviender Bukkapatnam
University of South Florida College of Medicine, Tampa, USA
J Urol 170:1111-4. 2003..Reports in the literature describe techniques that require several procedures and anesthetic sessions to effect extraction. We describe our experience with 1-step removal of retained ureteral stents...
- Bilateral partial ureteropelvic junction disruption after blunt trauma treated with indwelling ureteral stentsMichael A White
Urologic Consortium, Michigan State University College of Osteopathic Medicine, East Lansing, Michigan 49506, USA
Urology 69:384.e15-7. 2007..To our knowledge, this is the first documented case of conservative management of bilateral ureteropelvic junction disruption with indwelling ureteral stents...
- Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membraneJ H Miner
Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA
Dev Biol 217:278-89. 2000....
- Kidney development in the absence of Gdnf and Spry1 requires Fgf10Odysse Michos
Department of Genetics and Development, Columbia University, New York, New York, USA
PLoS Genet 6:e1000809. 2010..plays a minor role), as removal of even one copy of Fgf10 in Gdnf-/-;Spry1-/- mutants causes a complete failure of ureter and kidney development...
- Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidneyNina Perälä
Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
Differentiation 81:81-91. 2011....
- Antagonism of BMP4 signaling disrupts smooth muscle investment of the ureter and ureteropelvic junctionGerald J Wang
Departments of Urology and Physiology and Biophysics ABA, DL, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
J Urol 181:401-7. 2009..Recent evidence has shown that BMP4 may be involved in ureteral morphogenesis. We determined whether the disruption of BMP4 signaling results in abnormal smooth muscle investment of the ureter and ureteropelvic junction.
- Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesisU Muller
Department of Physiology, University of California, San Francisco 94143, USA
Cell 88:603-13. 1997..Consistent with these phenotypes, alpha8 expression is induced in mesenchymal cells upon contact with the ureter. Since none of its previously identified ligands appears likely to mediate the essential functions of alpha8 beta1 ..
- Overexpression of RET leads to vesicoureteric reflux in miceO H Yu
Department of Pediatrics, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
Am J Physiol Renal Physiol 287:F1123-30. 2004..urinary tract abnormality vesicoureteric reflux (VUR), in which urine flows retrogradely from the bladder to the ureter. Reflux was determined in vitro by injecting methylene blue into the bladders of HoxB7/Ret and wild-type mice...
- Gene discovery and vesicoureteric refluxInga J Murawski
Department of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
Pediatr Nephrol 23:1021-7. 2008Vesicoureteric reflux (VUR) is a congenital urinary tract defect caused by abnormal insertion of the ureter within the bladder wall...
- Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinaseMing Jer Tang
Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
Dev Biol 243:128-36. 2002..an in vitro organ culture assay, inhibition of PI3K completely blocks the GDNF-dependent outgrowth of ectopic ureter buds. PI3K is also essential for branching morphogenesis once the ureteric bud has invaded the kidney mesenchyme...
- Murine homolog of SALL1 is essential for ureteric bud invasion in kidney developmentR Nishinakamura
Division of Stem Cell Regulation, Institute of Medical Science, The University of Tokyo, Japan
Development 128:3105-15. 2001..This phenotype is likely to be primarily caused by the absence of the inductive signal from the ureter, as the Sall1-deficient mesenchyme is competent with respect to epithelial differentiation...
- Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract developmentYoichi Miyazaki
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
Kidney Int 63:835-44. 2003We have suggested that bone morphogenetic protein 4 (BMP4), acting on the Wolffian duct and ureter epithelium, determines the budding site of the ureter by locally antagonizing ubiquitous inductive signal(s) from the metanephric ..
- Critical and distinct roles for key RET tyrosine docking sites in renal developmentSanjay Jain
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genes Dev 20:321-33. 2006..Similar kidney and ureter defects were observed in RET9(Y1015F) mice that contain the Y1015F mutation in the RET9 isoform...
- Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesisIhor V Yosypiv
Department of Pediatrics, Tulane University Health Sciences Center, SL 37, 1430 Tulane Avenue, New Orleans, LA 70112, USA
J Am Soc Nephrol 17:1005-14. 2006..This process depends on tyrosine phosphorylation of the EGFR. Cooperation of AT(1)R and EGFR signaling therefore is important in the development of the renal collecting system...
- High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchymaDavid S Hains
Division of Nephrology, Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA
J Urol 183:2077-84. 2010..We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux...
- Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasiaSunder Sims-Lucas
Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
Am J Physiol Renal Physiol 297:F1208-19. 2009..Furthermore, Frs2alpha may transmit signals through other receptor kinases present in ureteric epithelium. Finally, the renal hypoplasia observed in Frs2alpha(UB-/-) mice is likely secondary to decreased Ret and Wnt11 expression...
- Recurrence and survival following laparoscopic radical nephroureterectomy with various forms of bladder cuff controlSurena F Matin
Section of Laparoscopic and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Urol 173:395-400. 2005..We document recurrence and survival following laparoscopic radical nephroureterectomy (LNUX) for upper tract transitional cell carcinoma (TCC) using primarily 2 methods of managing the bladder cuff...
- Inguino-scrotal hernia of a double district ureter: case report and literature reviewL Bertolaccini
Department of Surgical Activity, Maria Vittoria Hospital, Cibrario St 72, 10149 Turin, Italy
Hernia 9:291-3. 2005..b>Ureter inguinal hernias are nearly always indirect...
- Comparison of kidney-ureter-bladder abdominal radiography and computed tomography scout films for identifying renal calculiRichard Johnston
Department of Urology, Christchurch Public Hospital, Christchurch, New Zealand
BJU Int 104:670-3. 2009To assess the sensitivity of computed tomography (CT) scout topograms and kidney-ureter-bladder abdominal radiography (KUB) in detecting urinary tract stones.
- GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell behaviorsFrank Costantini
Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA
Organogenesis 6:252-62. 2010..Ret signaling, via Etv4 and Etv5, promotes competitive cell rearrangements in the nephric duct, in which the cells with the highest level of Ret signaling preferentially migrate to form the first ureteric bud tip...
- Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiationM Todd Valerius
Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Mech Dev 112:219-32. 2002..In situ hybridizations were used to confirm that selected novel genes were expressed in the developing kidney...
- Tomographic quantification of branching morphogenesis and renal developmentKieran M Short
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria 3800, Australia
Kidney Int 77:1132-9. 2010..To overcome this, we used optical projection tomography to image and reconstruct the branching ureter epithelium of ex vivo embryonic kidneys and developed software to quantify these three-dimensional (3D) data...
- Severely encrusted polyurethane ureteral stents: management and analysis of potential risk factorsI Singh
Department of Urology, All India Institute of Medical Sciences, New Delhi, India
Urology 58:526-31. 2001..It is important to maintain an efficient computerized stent log under the direct supervision of a physician. Patients with probable risk factors should be monitored even more frequently to avoid mishaps and morbidity...
- Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureterY Miyazaki
Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Clin Invest 105:863-73. 2000In the normal mouse embryo, Bmp4 is expressed in mesenchymal cells surrounding the Wolffian duct (WD) and ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously (Alk3) or ..
- Renal and neuronal abnormalities in mice lacking GDNFM W Moore
Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080, USA
Nature 382:76-9. 1996..Thus GDNF is important for the development and/or survival of enteric, sympathetic and sensory neurons and the renal system, but is not essential for catecholaminergic neurons in the central nervous system (CNS)...
- Lim 1 is required for nephric duct extension and ureteric bud morphogenesisAnissa Pedersen
Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Dev Biol 288:571-81. 2005..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
- Canonical WNT/beta-catenin signaling is required for ureteric branchingDarren Bridgewater
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Dev Biol 317:83-94. 2008..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
- Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting systemKevin T Bush
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, and Urological Diseases Research Center, Department of Urology, Children s Hospital, Boston, MA 02115, USA
Dev Biol 298:571-84. 2006..apparently normal ureters in the absence of a kidney, suggesting that the growth and development of the unbranched ureter is largely independent of the more proximal portions of the UB which differentiates into the highly branched renal ..
- Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesisY Lin
Biocenter Oulu and Department of Biochemistry, University of Oulu, Oulu, Finland
Dev Dyn 222:26-39. 2001..kidney demonstrate that cells expressing Wnt-2b are not capable of inducing tubule formation but instead stimulate ureter development. Incubation of isolated ureteric buds on such cells supports bud growth and branching...
- Angiotensin II AT2 receptor regulates ureteric bud morphogenesisRenfang Song
Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Am J Physiol Renal Physiol 298:F807-17. 2010..We conclude that AT2R performs essential functions during UB branching morphogenesis via control of the GDNF/c-Ret/Wnt11 signaling pathway, UB cell proliferation, and survival...
- Does the surgical technique for management of the distal ureter influence the outcome after nephroureterectomy?Véronique Phé
Academic Department of Urology of la Pitiè Salpétriére Hospital, Assistance Publique Hopitaux de Paris, Faculte de Medecine Pierre et Marie Curie, University Paris VI, Paris, France
BJU Int 108:130-8. 2011..Level of Evidence 4 What's known on the subject? and What does the study add? The resection of the distal ureter and its orifice is an oncological principle during radical nephroureterectomy which is based on the fact that it ..
- Changes in interstitial cell of Cajal-like cells density in congenital ureteropelvic junction obstructionPiotr Koleda
Department of Pathophysiology, Wroclaw Medical University, ul Marcinkowskiego 1, 50 368 Wroclaw, Poland
Int Urol Nephrol 44:7-12. 2012..The authors examined the number of interstitial cells of Cajal-like cells (ICC-LCs) in obstructed ureteropelvic junction (UPJ) in comparison with normal UPJ specimens and age-related changes...
- Transvaginal sonography in the morphological and functional assessment of segmental dilation of the distal ureterJ M Yang
Division of Urogynecology, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
Ultrasound Obstet Gynecol 27:449-51. 2006..imaging study had revealed a double uterus and obstructed left hemivagina, into which a single vaginal ectopic ureter inserted...
- Pneumovesicum method in en-Bloc laparoscopic nephroureterectomy with bladder cuff resection for upper-tract urothelial cancerChi Wai Cheng
Urology Team, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
J Endourol 21:359-63; discussion 362-3. 2007A novel technique for managing the distal ureter and bladder cuff during laparoscopic nephroureterectomy is introduced.
- Highly predictive survival nomogram after upper urinary tract urothelial carcinomaClaudio Jeldres
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
Cancer 116:3774-84. 2010....
- Fluoroscopy-guided transurethral removal and exchange of ureteral stents in female patients: technical notesSang Woo Park
Deparment of Radiology, Konkuk University Hospital, Konkuk University, School of Medicine, 4 12 Hwayang dong, Gwangjin gu, 143 729 Seoul, Republic of Korea
J Vasc Interv Radiol 18:251-6. 2007..To describe simple and safe techniques for transurethral removal and for exchange of ureteral stents in female patients under fluoroscopic guidance...
- Pediatric robotic extravesical ureteral reimplantation: comparison with open surgeryRyan P Smith
Department of Urology, University of Virginia, Charlottesville, Virginia, USA
J Urol 185:1876-81. 2011..We review a single surgeon experience and compare the outcomes of robotic assisted laparoscopic extravesical ureteral reimplantation and open ureteral reimplantation in children with vesicoureteral reflux...
- Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstructionR Nørregaard
The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark
Kidney Int 70:872-81. 2006..Rats were subjected to bilateral ureter obstruction. Ureters were removed and dissected into a proximal dilated and distal non-dilated segment...
- Rates of urinary tract injury from gynecologic surgery and the role of intraoperative cystoscopyD T Gilmour
Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
Obstet Gynecol 107:1366-72. 2006..To estimate the rates of urinary tract injury after benign gynecologic surgery. To explore the role of routine intraoperative cystoscopy at benign gynecologic surgery...
- Double ureter and duplex system: a cadaver and radiological study- Prakash
Department of Anatomy, Vydehi Institute of Medical Sciences and Research Center, Karnataka, India
Urol J 8:145-8. 2011To study the prevalence of duplex system and double ureter in cadavers and intravenous pyelograms in Indian population.
- A sealed bladder cuff technique during laparoscopic nephroureterectomy utilizing the LigaSure electrosurgical device: laboratory and clinical experienceErica H Lambert
Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Endourol 24:327-32. 2010..Controversy exists over the optimal technique for the distal ureter and bladder cuff (DUBC) excision...
- Morphology, calcium signaling and mechanical activity in human ureterRachel V Floyd
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
J Urol 180:398-405. 2008We determined the mechanisms of calcium signaling in the human ureter, and the relationship to peristaltic contractions and bundular structure in living tissue, thereby advancing the understanding of ureteral function in health and ..
- Laparoscopic radical nephroureterectomy with en-bloc distal ureteral and bladder cuff excision using a single position pneumovesicum methodThomas J Guzzo
The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 72:850-2. 2008We describe a completely laparoscopic approach for en-bloc dissection of the distal ureter and bladder cuff during nephroureterectomy using a pneumovesicum approach and with the need for intraoperative patient repositioning...
- Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstructionFabio Bartoli
Division of Pediatric Surgery, University of Foggia, Foggia, Italy
J Pediatr Surg 46:530-6. 2011..The aim of this study is to evaluate the urinary excretion of these cytokines and β2-microglobulin (β2M) in children with urine flow impairment at the ureteropelvic junction or who underwent pyeloplasty...
- Propagation characteristics of the electrical impulse in the normal and obstructed ureter as determined at high electrophysiological resolutionFayez T Hammad
Department of Surgery, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
BJU Int 108:E36-42. 2011..To investigate the propagation of the electrical impulses in a unilateral ureteric obstruction model using a high-resolution technique in vivo...
- GLI3 repressor controls functional development of the mouse ureterJason E Cain
Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Invest 121:1199-206. 2011..forms of hydronephrosis (increased diameter of the renal pelvis and calyces) and hydroureter (dilatation of the ureter) are the most frequently detected antenatal abnormalities, yet the underlying molecular mechanisms are largely ..
- Endometriosis of ureter-induced recurrent urinary tract infections in a premenopausal woman--case reportK Stamatiou
Department of Urology, Tzaneion General Hospital, Piraeus, Greece
Clin Exp Obstet Gynecol 34:63-4. 2007..The ureters and kidneys are the least usual place of localization. Endometriosis of the ureter often leads to silent loss of renal function due to delayed diagnosis...
- Effects of a non-selective COX inhibitor and selective COX-2 inhibitors on contractility of human and porcine ureters in vitro and in vivoV Chaignat
Division of Veterinary Pharmacology and Toxicology, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty Berne, University of Berne, Berne, Switzerland
Br J Pharmacol 154:1297-307. 2008..COX-1 and COX-2 receptors were identified in human ureter and kidney.
- Pharmacologic manipulation of the porcine ureter: Acute impact of topical drugs on ureteral diameter and peristaltic activityCaroline D Ames
Department of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
J Endourol 20:943-8. 2006..We characterized the in-vivo effects of intraluminal application of verapamil and theophylline on ureteral peristalsis and diameter in a porcine model...
- Prospective long-term analysis of nerve-sparing extravesical robotic-assisted laparoscopic ureteral reimplantationSanjay Kasturi
Department of Surgery, Division of Urology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Urology 79:680-3. 2012....
- Decellularized ureter for tissue-engineered small-caliber vascular graftYuji Narita
Department of Clinical Cell Therapy and Tissue Engineering, Nagoya University School of Medicine, Nagoya, 466 8550, Japan
J Artif Organs 11:91-9. 2008..These results suggest that tissue-engineered DUs may be a potential alternative conduit for bypass surgery...
- Changes in the urine composition during its passage through the ureter. A concept of urothelial functionAhmed Shafik
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
Urol Res 33:426-8. 2005..Based on this concept, we investigated the hypothesis that urine undergoes changes during its passage in the ureter. Urine samples were separately collected from the renal pelvis and ureters of 23 volunteers (15 men, eight women, ..
- Abnormalities in ureter and kidney development in mice given acetazolamide-amiloride or dimethadione (DMO) during embryogenesisT A Miller
Children s Hospital Research Foundation, Cincinnati, Ohio
Teratology 46:541-50. 1992..or a single dose of dimethadione (DMO), the active metabolite of trimethadione, on the development of the ureter. When acetazolamide-amiloride was administered in C57BL/6NCrlBR mice on day 9, 9...
- Retroperitoneal laparoscopic radical nephrectomy and nephroureterectomy and comparison with open surgeryApul Goel
All India Institute of Medical Sciences, Department of Urology, Ansari Nagar, New Delhi, 110 029 India
World J Urol 20:219-23. 2002..An oncologically complete removal of the tumour is possible as in open surgery. The retroperitoneoscopic approach is associated with less morbidity and faster recovery...
- A novel technique for ureteral catheterization and/or retrograde ureteroscopy after cross-trigonal ureteral reimplantationM Chad Wallis
Section of Urology, Columbus Children s Hospital, Ohio 43205, USA
J Urol 170:1664-6; discussion 1666. 2003A criticism of the Cohen cross-trigonal reimplantation is the potential difficulty of retrograde access to the ureter. With the advent of modern endourological equipment, we devised a novel technique that obviates the aforementioned ..
- Mechanisms of Renoprotection by Soluble Epoxide Hydrolase InhibitionDeanna L Kroetz; Fiscal Year: 2013..The renoprotective properties of sEH inhibition will be studied in both a unilateral ureter ligation model and in ischemia/reperfusion...
- Transcriptional mechanisms of lower urinary tract developmentGerald Mingin; Fiscal Year: 2013DESCRIPTION (provided by applicant): Congenital abnormalities of the upper (kidney) and lower (ureter, bladder, urethra and external genitalia) urinary tracts are diagnosed at a rate of 1 in 500 prenatal ultrasounds...
- Clinical Outcomes for Siblings of Children with Vesico-Ureteral RefluxCALEB PENNELL NELSON; Fiscal Year: 2013..VUR is the retrograde flow of urine from the bladder into the ureter and kidney, and is associated with urinary tract infection (UTI) and renal injury...
- Vitamin A dependent events in urinary tract formation.Cathy Mendelsohn; Fiscal Year: 2009..stages of urogenital tract formation, in the kidney for branching morphogenesis and in the common nephric duct for ureter transposition...
- DLGH1 AND UROGENITAL DEVELOPMENTWOJCIECH A SWAT; Fiscal Year: 2012..studies show that DLGH1 is expressed strongly in the urothelium and weakly in other cells of the ureter. We will determine which cellular compartment must express Dlgh1 for normal smooth muscle cell alignment and for ..
- Molecular Events in Urinary Tract FormationCATHY LEE MENDELSOHN; Fiscal Year: 2012..The bladder and urethra form independently of the kidney and ureter, connecting at midgestation to form a patent outflow tract...
- Molecular Pathogenesis of Vesicoureteral RefluxWeining Lu; Fiscal Year: 2012..Lastly, given the abnormal ureteric branching and ureter elongation defects in Robo2 deficient mice and substantial actions of Robo/Slit signaling in neural development, ..
- Urogenital System Development: The Acquisition of Coordinated Ureter PeristalsisDoris A Herzlinger; Fiscal Year: 2013..of the smooth muscle coat surrounding the kidney outflow tract (OT), including the renal calyces, pelvis and ureter, are essential for draining urine out of the kidney...
- NEW INSIGHTS INTO ROLE OF RET IN UROGENITAL DEVELOPMENT AND ANOMALIESSanjay Jain; Fiscal Year: 2013..Ret reporter and RetY1015F mice to delineate abnormalities in the anterior Wolffian duct, UB position and distal ureter maturation that lead to CAKUT-like defects in these mice...
- Biochemical and Functional Studies of Sall1 in Kidney Development and TBSMICHAEL I RAUCHMAN; Fiscal Year: 2010..These mice display renal hypoplasia with reduced branching of the ureter, similar to that seen in TBS patients...
- Genetic Control of Ureter and Kidney DevelopmentFRANKLIN D COSTANTINI; Fiscal Year: 2013..alterations in the normal processes of ureteric bud induction, growth, and branching during the development of the ureter and the renal collecting duct system...
- Murine Atlas of Genitourinary DevelopmentMelissa Little; Fiscal Year: 2009..and will continue to do so) expression profilng data from across time and space in the developing kidney and ureter. Hence we have defined a set of approximately 2500 genes tht we know are involved in UGT development...
- Branching Morphogenesis of Urinary Epithelia: from Genes to Cellular BehaviorsFRANKLIN D COSTANTINI; Fiscal Year: 2013..of a single ureteric bud (UB) at the proper location on the Wolffian duct (WD) is important to make a functional ureter, while complex patterns of UB branching morphogenesis are required for normal renal organogenesis...
- Surgical Laser device development for precise or bulk ablation of urologic tissueJonathon D Wells; Fiscal Year: 2010..Surgical lasers form the standard of care for many treatments and endoscopic procedures in the prostate, kidney, ureter, bladder, and urethra...
- Computer-Aided Detection of Urinary Tract Cancer on MDCT UrographyLUBOMIR M HADJIYSKI; Fiscal Year: 2013..In order to accomplish these tasks, we will develop new image analysis techniques for automated tracking of the ureter and segmentation of the inner and outer walls of the bladder and the ureter...
- A genetic model of vesicoureteral reflux and reflux nephropathyCARLTON MATTHEW BATES; Fiscal Year: 2012DESCRIPTION (provided by applicant): Vesicoureteral reflux (VUR- backflow of urine from the bladder into the ureter) is the most common urogenital anomaly in children and reflux nephropathy is the 4th leading cause of chronic renal ..
- Roles of transcription factors in kidney developmentPin Xian Xu; Fiscal Year: 2012..MM), the outgrowth of the ureteric bud (UB), and its correctly patterned branching morphogenesis to generate the ureter and the renal collecting system...
- Ureteric Bud PatterningDoris A Herzlinger; Fiscal Year: 2013..morphogenesis forming the intra-renal collecting system whereas its distal or trunk domain differentiates into the ureter. Abnormal regulation of ureteric bud morphogenesis can result in a spectrum of congenital defects, the most common ..
- Staging of upper tract urothelial cancer with optical coherence tomographyHui Zhu; Fiscal Year: 2013..tissue specimens for pathohistological staging cannot be acquired because of the limited manipulation space in the ureter and renal pelvis and the potential risk of perforating thin ureteral wall if deep biopsyis attempted...
- FLORIDA FIREFIGHTER CANCER INCIDENCE AND MORTALITYLora Fleming; Fiscal Year: 2001..Excess mortality for cancer of the lung, kidney and ureter, rectum and colon, and skin has also been reported...
- Optimizing anti-virulence compounds for the treatment of UTIsSARAH ELIZABETH GREENE; Fiscal Year: 2013..pili and the function of pilicides in host-like environments, such as after growth in urine or attachment to human ureter tissue. We also have evidence that pilicides have other effects on UPEC in addition to disrupted pilus assembly...
- Strategies for Improved Shock Wave LithotripsyJAMES ALEXANDER MCATEER; Fiscal Year: 2013..from SWL adverse effects * Determine the properties of SWs at their site of action in the kidney and proximal ureter * Increase the efficiency of SWL by improving the acoustic coupling between the lithotripter and the patient * ..
- 3D atlas & database of murine urogenital developmentRichard Baldock; Fiscal Year: 2010..anatomical ontology, a catalogue of cell types and a quantitative morphological description of mouse kidney, ureter and bladder development, which will provide a baseline for future studies that examine the effects of experimental ..
- Regulaton of Urothelial GrowthTung Tien Sun; Fiscal Year: 2007The luminal surface of the entire lower urinary tract including renal pelvis, ureter, bladder and proximal urethra is lined by a cell type described in standard textbooks as the transitional epithelium or urothelium, which is ..
- Elastic biodegradable ureteral stentHaesun Park; Fiscal Year: 2009..There are many surgical procedures that require the emplacement of a ureteral stent. The ureter is a tube that allows urine to flow from the kidney to the bladder...
- POPULATION BASED STUDY OF LOWER URINARY TRACT TUMORSLoraine Marrett; Fiscal Year: 1980..of bladder tumor (BT) and other lower urinary tract tumors (LUTT), including tumors of the renal pelvis, ureter, and urethra...
- CONFERENCE ON GENOMIC INSTABILITY AND DYSREGULATIONCharles Fox; Fiscal Year: 1991..Bubbles will be generated in the renal artery, parenchyma, collecting system, ureter, vena cava and in the urinary bladder (a relatively easy site suitable for evaluation of reflux and as part of a ..
- Transcriptional regulation of bladder-ureter developmentH Stadler; Fiscal Year: 2007..GS) Syndromes, two autosomal dominant disorders that profoundly affect the development of the limb, bladder, ureter, uterus, and external genitalia...
- ENHANCING BRAIN UPTAKE OF AZT BY TRANSPORT INHIBITIONRonald Sawchuk; Fiscal Year: 1991..Additional experiments will be performed in ureter- cannulated animals to characterize renal clearance of AZT as a function of plasma concentration of inhibitor...
- HOXA 13 REGULATION OF GENITOURINARY DEVELOPMENTH Stadler; Fiscal Year: 2002..prostate, uterine, Mullerian duct, vaginal bladder, ureter. and rectal defects...
- Urothelial Differentiation in Interstitial CystitisMonica Liebert; Fiscal Year: 2004..Normal urothelial cells will be harvested from urothelial tissues (bladder or ureter) and evaluated by flow cytometry, immunostaining, RT-PCR and Northern and Western blotting for expression of a ..
- Calcineurin in Congenital NephropathyFeng Chen; Fiscal Year: 2004..These mice have deletion of CnB in the excretory system, including the smooth muscle cells in the ureter. The affected mice have hydronephrosis and hydroureter and die from postnatal renal failure...
- A New Transgenic Approach for the KidneyPumin Zhang; Fiscal Year: 2004The development of the mammalian kidney is a very complex process, involving branching morphogenesis of the ureter and the formation of nepherons...
- Fox genes in urinary tract developmentTsutomu Kume; Fiscal Year: 2005..that the impairment of embryonic steps, the ureteric budding and differentiation of smooth muscle around the ureter, leads to urinary tract abnormalities such as hydroureter and hydronephrosis...
- CELL INTERACTIONS IN DEVELOPMENT OF THE MAMMALIAN KIDNEYAndrew McMahon; Fiscal Year: 2007..expression is positioned just beneath the branch tips while that of Wnt7b is more distal and extends into the ureter. We have generated mutant alleles that allow the conditional removal of Wnt l5 and Wnt7b activities and we will ..
- Genetic Determinants of Vesicoureteral RefluxAli Gharavi; Fiscal Year: 2007..Identification of the gene(s) for VUR will provide insight in the biology of ureter and bladder development...
- Generation /Analysis of Mice Carrying GFP-tagged Genes in Kidney DevelopmentPumin Zhang; Fiscal Year: 2009..The development of the mammalian kidney is a very complex process, involving branching morphogenesis of the ureter and the formation of nepherons...
- Identification of Genes Regulating Ureter MorphogenesisSanjay Nigam; Fiscal Year: 2007The ureter develops out of the ureteric bud (UB), but most work on the UB to date has focused on branching morphogenesis as it relates to development of the kidney collecting ducts...
- Towards renal regenerationMelissa Little; Fiscal Year: 2004..into the omentum for vascularisation, together with reconnection to the excretory tract via a replacement ureter. Endogenous renal repair would involve the reintroduction and integration of induced and isolated renal progenitor ..
- Gene transfer to the kidney using lentiviral vectorsFrank Park; Fiscal Year: 2004..to be elucidated, and so we propose to inject lentiviral vectors through different routes: the renal artery, the ureter or directly into the renal interstitium...
- BIOMEDICAL ENGINEERING CENTER FOR POLYMER IMPLANTSDonald Lyman; Fiscal Year: 1980..The associated projects include Ureter and Bladder Repair, Development of Small Diameter Vascular Prostheses, Development of Polymeric Nerve Prostheses, ..
- TRANSCRIPTIONAL CONTROL OF KIDNEY MORPHOGENESISEseng Lai; Fiscal Year: 2000..the nephrogenic mesenchyme is inhibited, as is the growth and branching of the collecting system and growth of the ureter. These studies suggested that interactions between the stromal mesenchyme and the developing epithelial components ..
- PATHOGENIC MECHANISMS OF ICAda Elgavish; Fiscal Year: 1993..Using epitheilial and fibroblast cell cultures we isolate from the urinary bladder and the ureter, we propose a carefully developed plan to begin sorting out mechanisms which are likely to be involved in the ..
- DEVELOPMENT OF THE URINARY COLLECTING SYSTEMSanjay Nigam; Fiscal Year: 2003..We aim to characterize their: 1) spatiotemporal patterns of expression during development of the ureter and collecting ducts (Northerns, in situ hybridization, immunohistochemistry); 2) clone and sequence any novel ..
- SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESISFRANKLIN COSTANTINI; Fiscal Year: 2001..Finally, new types of mutants and transgenic mice will be generated to study the role of Fused in mouse embryogenesis. ..
- SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESISFRANKLIN COSTANTINI; Fiscal Year: 2007..abstract_text> ..
- BIOENGINEERING OF BLADDER TISSUESAnthony Atala; Fiscal Year: 2003..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
- CYTOKINES CONVERT EPITHELIAL PRECURSORS TO NEPHRONSJonathan M Barasch; Fiscal Year: 2010..We apply the basic ideas and tools of cell biologyto define the course of polarization and establish a fluorescent polarity mouse to evaluate the entire transition form mesenchyme to epithelia. ..
- Insulin Producing Cells from Amniotic Stem Cells for Diabetes TherapyAnthony Atala; Fiscal Year: 2009..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
- ROLE OF TNF IN BLADDER INFLAMMATIONDavid J Klumpp; Fiscal Year: 2010..This project will determine the prevalence of RANTES as a novel IC biomarker in urines and then quantify the efficacy of mechanistically-directed therapies in murine models. ..
- ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICSRICHARD ZAGER; Fiscal Year: 2001....
- MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSEAnthony Visco; Fiscal Year: 2002..This study would be the first large-scale comprehensive description of collagen cross-linking, lysine hydroxylation, and of genes coding for enzymes involved in the cross-linking process, in patients with pelvic organ prolapse. ..
- TNF Mediates Obstruction-Induced Renal InjuryKIRSTAN MELDRUM; Fiscal Year: 2008..and enhance the knowlegde gained by the applicant during her residency and fellowship training to develop a clinically relevant therapeutic approach to the treatment and prevention of obstructive renal injury [unreadable] [unreadable]..
- Membrane Organisation by Tetraspanins and Small Multi-transmembraneTung Tien Sun; Fiscal Year: 2006..abstract_text> ..
- The Role of Bone Morphogenetic Protein-7 in Renal Endothelial Cell BiologyJeremiah Morrissey; Fiscal Year: 2008..000 for each patient. This proposal examines a treatment designed to delay or halt the progression of renal disease thereby saving a significant portion of the yearly Medicare budget. [unreadable] [unreadable] [unreadable]..
- Immune Response to Polyomavirus InfectionParmjeet S Randhawa; Fiscal Year: 2010..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
- 2nd International Cervical Cancer ConferenceMichele Follen; Fiscal Year: 2002..Each session chair and speaker has been chosen based on his/her publications, funding and national reputation. ..
- Differentiation of ES Cells into Renal EpitheliaGregory Dressler; Fiscal Year: 2006..Since ES cells potentially represent an unlimited supply of renal progenitors, these experiments will lay the foundation for cell based therapies to improve the efficacy of ATN treatment. ..
- Cesarean After Sphincter Tear (CAST) RCT Planning GrantAnthony Visco; Fiscal Year: 2005..The upfront investment of time and resources will result in the submission of an efficient and well-designed R01 application that can be implemented in a timely fashion. ..
- Bcl-2 & Branching MorphogenesisChristine Sorenson; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Peripheral Arterial Disease and Leg Muscle MetabolismLOIS KILLEWICH; Fiscal Year: 2005..It is my ultimate hope that the combined interventions of bypass surgery and nutritional supplementation with amino acids can be used to improve overall functional status of these elderly Americans. ..
- Race Differences in Female UI: Epidemiology and BiologyJohn DeLancey; Fiscal Year: 2005..Knowledge of these factors can then provide the basis for risk factor identification and the development of preventive strategies appropriate to different racial groups. ..
- Cell Signaling in Developing EpitheliaGregory R Dressler; Fiscal Year: 2010..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..
- Role of polycystin-1 in centrosome duplication and cell cycle controlGABRIELE LUCA GUSELLA; Fiscal Year: 2010..Our study will contribute to ongoing efforts assessing the therapeutic potential for cell cycle inhibitors in the treatment of ADPKD. ..
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLsStephen Nakada; Fiscal Year: 2005..While the specific model of this proposal involves urothelial cells cultured from the ureter, this novel concept has broad implications in the pathophysiology of the urinary tract...