ureter

Summary

Summary: One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the BLADDER.

Top Publications

  1. ncbi Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
    K Stark
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 372:679-83. 1994
  2. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
  3. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
  4. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
  5. ncbi Interstitial cell of Cajal-like cells in the upper urinary tract
    R J Lang
    Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
    J Cell Mol Med 9:543-56. 2005
  6. pmc Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
    Dev Dyn 240:240-9. 2011
  7. pmc Ureteric branching morphogenesis in BMP4 heterozygous mutant mice
    Jason E Cain
    Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Victoria, Australia
    J Anat 209:745-55. 2006
  8. ncbi Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration
    Vitaly Margulis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 115:1224-33. 2009
  9. ncbi Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling
    Andrea Brenner-Anantharam
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 134:1967-75. 2007
  10. ncbi Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse
    Inga J Murawski
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Quebec, Canada
    Am J Physiol Renal Physiol 293:F1736-45. 2007

Detail Information

Publications357 found, 100 shown here

  1. ncbi Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
    K Stark
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 372:679-83. 1994
    ..In response to a signal from the ureter, mesenchymal cells condense, aggregate into pretubular clusters and undergo an epithelial conversion generating a ..
  2. pmc Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 18:698-712. 2010
    ..In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas...
  3. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ....
  4. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    Dysfunction of the ureter often leads to urine flow impairment from the kidney to the bladder, causing dilation of the ureter and/or renal pelvis...
  5. ncbi Interstitial cell of Cajal-like cells in the upper urinary tract
    R J Lang
    Department of Physiology, Faculty of Medicine and Health Sciences, Monash University, Clayton, 3168, Victoria, Australia
    J Cell Mol Med 9:543-56. 2005
    ..SMC after pyeloureteral/ureteral obstruction or surgery, ICC-like cell pacemaking provides a compensatory mechanism allowing the ureter to maintain rudimentary peristaltic waves and movement of urine from the pyelon towards the bladder.
  6. pmc Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
    Dev Dyn 240:240-9. 2011
    ..Beyond E12.5, Fgfr1(Mes-/-)Fgfr2IIIc-/- mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development...
  7. pmc Ureteric branching morphogenesis in BMP4 heterozygous mutant mice
    Jason E Cain
    Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Victoria, Australia
    J Anat 209:745-55. 2006
    ..In addition, reduced endogenous levels of BMP4 do not alter the inhibitory effects of exogenous BMP4 on ureteric branching or amplification of normal renal asymmetry...
  8. ncbi Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration
    Vitaly Margulis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 115:1224-33. 2009
    ..A large series of patients treated with radical nephroureterectomy for UTUC were studied, and variables associated with poor prognosis were identified...
  9. ncbi Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling
    Andrea Brenner-Anantharam
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 134:1967-75. 2007
    ..tract morphogenesis requires the sub-division of the ureteric bud (UB) into the intra-renal collecting system and ureter, two tissues with unique structural and functional properties...
  10. ncbi Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse
    Inga J Murawski
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Quebec, Canada
    Am J Physiol Renal Physiol 293:F1736-45. 2007
    ..In VUR, urine flows retrogradely from the bladder to the ureter and is associated with urinary tract infections, hypertension, and renal failure...
  11. ncbi Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4
    Xavier Caubit
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, Marseille, France
    Development 135:3301-10. 2008
    ..Ex vivo, the spontaneous contractions that occurred in proximal segments of wild-type embryonic ureter explants were absent in Tshz3 mutant ureters...
  12. ncbi Renal abnormalities and their developmental origin
    Andreas Schedl
    INSERM, U636, F 06108 Nice, France
    Nat Rev Genet 8:791-802. 2007
    ..Moreover, defects in nephron formation can predispose to Wilms tumour, the most frequent solid tumour in children. To understand the basis of human renal diseases, it is essential to consider how the kidney develops...
  13. pmc Tbx18 regulates the development of the ureteral mesenchyme
    Rannar Airik
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Clin Invest 116:663-74. 2006
    ..They are often caused by physical obstruction or by functional impairment of the peristaltic machinery of the ureter. The underlying molecular and cellular defects are, however, poorly understood...
  14. pmc Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development
    Susan M Kiefer
    John Cochran Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Development 137:3099-106. 2010
    ..expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...
  15. pmc Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney
    R Brandenberger
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 154:447-58. 2001
    ..The approaches used here should be generally useful for characterizing the interactions of novel extracellular matrix proteins identified through genomic sequencing projects...
  16. ncbi Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT
    Iekuni Ichikawa
    Department of Pediatrics, Vanderbilt University Medical Center, MCN C4204, 21st and Garland Avenue, Nashville, TN 37232 2584, USA
    Kidney Int 61:889-98. 2002
    Ectopic budding of the ureter from the Wolffian duct is the first ontogenic misstep that leads to many-if not all-congenital anomalies of the kidney and urinary tract (CAKUT)...
  17. ncbi The modified sting procedure to correct vesicoureteral reflux: improved results with submucosal implantation within the intramural ureter
    Andrew J Kirsch
    Department of Pediatric Urology, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
    J Urol 171:2413-6. 2004
    ..We describe a modification of the technique used for implantation that has significantly improved our results...
  18. ncbi Regulation of BMP7 expression during kidney development
    R E Godin
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 125:3473-82. 1998
    ..By contrast, BMP7 expression in the metanephric mesenchyme is dependent on proteoglycans and possibly Wnt signaling...
  19. ncbi Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
    Jamie A Davies
    The Department of Anatomy, Edinburgh University, Edinburgh, UK
    Hum Mol Genet 13:235-46. 2004
    ....
  20. ncbi Creation of ureteropelvic junction obstruction and its correction by chemical glue-assisted laparoscopic dismembered pyeloplasty
    Allen W Chiu
    Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
    J Endourol 17:23-8. 2003
    ..We established a porcine model of ureteropelvic junction (UPJ) obstruction using a laparoscopic technique and assessed the outcome of standard suture-assisted and chemical glue-assisted laparoscopic pyeloplasty...
  21. pmc Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney
    Vidya K Nagalakshmi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Kidney Int 79:317-30. 2011
    ..Furthermore, an understanding of miRNA action may provide new insights into the etiology and pathogenesis of renal cyst-based kidney disease...
  22. pmc Angiotensin II stimulates in vitro branching morphogenesis of the isolated ureteric bud
    Renfang Song
    Division of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Mech Dev 128:359-67. 2011
    ..We conclude that Ang II-regulated genes in the iUB may be important mediators of Ang II-induced UB branching. We hypothesize that Ang II-dependent cell movements play an important role in UB branching morphogenesis...
  23. ncbi Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme
    Rannar Airik
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Hum Mol Genet 19:4918-29. 2010
    Congenital ureter anomalies, including hydroureter, affect up to 1% of the newborn children. Despite the prevalence of these developmental abnormalities in young children, the underlying molecular causes are only poorly understood...
  24. pmc Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases
    Noriko Uetani
    Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 119:924-35. 2009
    Congenital anomalies affecting the ureter-bladder junction are frequent in newborns and are often associated with other developmental defects...
  25. ncbi The effects of ureteral obstruction on Cajal-like cells in rats
    Baris Kuzgunbay
    Department of Urology, Cukurova University, Adana 01330, Turkey
    J Pediatr Urol 5:269-73. 2009
    ..To determine the changes in number and morphology of interstitial cells of Cajal (ICC)-like cells (ICC-LC) at the ureteropelvic junction (UPJ) of rats after experimental distal ureteral obstruction...
  26. ncbi Novel technique for management of distal ureter and en block resection of bladder cuff during hand-assisted laparoscopic nephroureterectomy
    Itay Y Vardi
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 67:89-92. 2006
    ..our experience with a novel flexible cystoscopic approach to excise the en block bladder cuff and juxtavesical ureter during hand-assisted laparoscopic nephroureterectomy...
  27. ncbi Dynamic hydrodistention classification of the ureter and the double hit method to correct vesicoureteral reflux
    Wolfgang H Cerwinka
    Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta 30342, USA
    Arch Esp Urol 61:882-7. 2008
    The objective of this monograph is to familiarize the reader with dynamic hydrodistention classification of the ureter and Hydrodistention Implantation Technique (HIT) methodology for the endoscopic correction of vesicoureteral reflux (..
  28. ncbi A sealed laparoscopic nephroureterectomy: a new technique
    Alexander Tsivian
    Department of Urologic Surgery, Wolfson Medical Center, Holon, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur Urol 52:1015-9. 2007
    ..To describe a purely laparoscopic nephroureterectomy approach that avoids the disadvantages of transurethral bladder cuff excision and open/laparoscopic distal ureterectomy using the EndoGIA...
  29. ncbi Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis
    Shao Ling Zhang
    University of Montreal, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon Masson, Montreal, Quebec, Canada
    J Am Soc Nephrol 18:2105-15. 2007
    ..Taken together, these data demonstrate that high glucose alters UB branching morphogenesis. This occurs, at least in part, via reactive oxygen species generation, activation of Akt signaling, and upregulation of Pax-2 gene expression...
  30. ncbi Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoceptors in human ureter
    Hyoung Keun Park
    Department of Urology, College of Medicine, Dongguk University, Gyeongju, Republic of Korea
    Urol Res 35:325-9. 2007
    ..subtypes was examined by immunohistochemistry using subtype selective antibodies in proximal, mid and distal ureter. Ureter samples were obtained from pathological specimens of nephroureterectomy...
  31. ncbi Laparoscopic ureteroneocystostomy and psoas hitch for post-hysterectomy ureterovaginal fistula
    Pranjal Modi
    Department of Urology and Transplantation Surgery, Institute of Kidney Diseases and Research Centre, Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India
    J Urol 180:615-7. 2008
    ..We assessed the results of laparoscopic ureteroneocystostomy with a psoas hitch for iatrogenic lower ureteral injuries leading to a ureterovaginal fistula...
  32. ncbi Management of ureteric injuries during gynecological operations: 10 years experience
    Panos Sakellariou
    Department of Urology, Alexandra Maternity Hospital, Athens, Greece
    Eur J Obstet Gynecol Reprod Biol 101:179-84. 2002
    ..To present our 10 years experience in the management of ureteric injuries occurring during gynecological surgery...
  33. ncbi The expression of Cajal cells at the obstruction site of congenital pelviureteric junction obstruction and quantitative image analysis
    Xinghai Yang
    Department of Pediatric Surgery, Hubei Women and Children s Hospital, Wuhan 430070, People s Republic of China
    J Pediatr Surg 44:2339-42. 2009
    ..The study aimed to analyze the expression and significance of interstitial cells of Cajal (ICC) at the obstruction site of congenital pelviureteric junction obstruction (PUJO)...
  34. ncbi Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction
    M Albert Basson
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
    Dev Cell 8:229-39. 2005
    ..These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations...
  35. ncbi Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction
    Valeria Solari
    Children s Research Centre, Our Lady s Hospital for Sick Children, Dublin, Ireland
    J Urol 170:2420-2. 2003
    Peristaltic contractions in the upper urinary tract serve to move urine from the kidney through the ureter to the bladder. Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children...
  36. pmc Functional obstruction: the renal pelvis rules
    Cathy Mendelsohn
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:957-9. 2004
    ..New animal models reveal molecular pathways important for peristalsis and point to the central role of the renal pelvis in urine transport...
  37. ncbi Examination of alpha 1 adrenoceptor subtypes in the human ureter
    Yasunori Itoh
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Int J Urol 14:749-53. 2007
    ..This study was carried out to characterize the alpha 1 adrenoceptors (AR) subtype gene and protein expression in the proximal, medial, and distal regions of the human ureter with the aim of facilitating stone expulsion.
  38. ncbi Long-term comparative outcomes of open versus laparoscopic nephroureterectomy for upper urinary tract urothelial-cell carcinoma after a median follow-up of 13 years*
    Grant D Stewart
    Edinburgh Urological Cancer Group, University of Edinburgh, Department of Urology, Western General Hospital, Edinburgh, United Kingdom
    J Endourol 25:1329-35. 2011
    ..The longest published follow-up of LNU is 7 years. We report outcomes for patients having surgery ≥10 years ago...
  39. ncbi Cajal-like cells in the human upper urinary tract
    Roman Metzger
    Department of Pediatric Surgery, University of Munich, Germany
    J Urol 172:769-72. 2004
    ..It is still unknown if ICCs also occur in the human upper urinary tract. Since these cells express and are marked by the c-kit receptor CD117, we investigated its occurrence and distribution along the human upper urinary tract...
  40. ncbi Cajal-like cells in the upper urinary tract: comparative study in various species
    Roman Metzger
    Department of Pediatric Surgery, University of Munich, Munich, Germany
    Pediatr Surg Int 21:169-74. 2005
    ..Normal proximal, middle, and distal ureter segments were analyzed in rodents, carnivores, porcines, cow, and humans...
  41. ncbi Surgical treatment of ureteral obstruction from endometriosis: our experience with thirteen cases
    Alessandro Antonelli
    Clinica Urologica, Spedali Civili di Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy
    Int Urogynecol J Pelvic Floor Dysfunct 15:407-12; discussion 412. 2004
    ..results as extended ureteral resection can be performed and continuity of the urinary tract can be restored without resorting to the distal pelvic ureter, which is often affected by the disease besides being more subject to relapses.
  42. ncbi Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development
    Randy S Levinson
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 132:529-39. 2005
    ....
  43. ncbi Laparoscopic mid sagittal hemicystectomy and bladder reconstruction with small intestinal submucosa and reimplantation of ureter into small intestinal submucosa: 1-year followup
    Jaime Landman
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri
    J Urol 171:2450-5. 2004
    ..We evaluated the long-term results of laparoscopic hemicystectomy and bladder replacement with small intestinal submucosa (SIS) with ureteral reimplantation into the SIS material...
  44. pmc Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers
    Richard J Lang
    Department of Physiology, Monash University, Clayton 3800, Australia
    J Physiol 576:695-705. 2006
    ....
  45. ncbi Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT
    Yoichi Miyazaki
    Departments of Pediatrics and Medicine, Vanderbilt University Medical Center Nashville, TN, USA
    Pediatr Int 45:598-604. 2003
    Ectopic budding of the initial ureter from the Wolffian duct is the first ontogenic misstep that leads to many congenital anomalies of the kidney and urinary tract (CAKUT)...
  46. ncbi Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development
    A Schuchardt
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, NY 10032, USA
    Development 122:1919-29. 1996
    ..This factor appears to stimulate the initial evagination of the ureteric bud from the Wolffian duct, as well as its subsequent growth and branching...
  47. ncbi 1-step removal of encrusted retained ureteral stents
    Raviender Bukkapatnam
    University of South Florida College of Medicine, Tampa, USA
    J Urol 170:1111-4. 2003
    ..Reports in the literature describe techniques that require several procedures and anesthetic sessions to effect extraction. We describe our experience with 1-step removal of retained ureteral stents...
  48. ncbi Bilateral partial ureteropelvic junction disruption after blunt trauma treated with indwelling ureteral stents
    Michael A White
    Urologic Consortium, Michigan State University College of Osteopathic Medicine, East Lansing, Michigan 49506, USA
    Urology 69:384.e15-7. 2007
    ..To our knowledge, this is the first documented case of conservative management of bilateral ureteropelvic junction disruption with indwelling ureteral stents...
  49. ncbi Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane
    J H Miner
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 217:278-89. 2000
    ....
  50. pmc Kidney development in the absence of Gdnf and Spry1 requires Fgf10
    Odysse Michos
    Department of Genetics and Development, Columbia University, New York, New York, USA
    PLoS Genet 6:e1000809. 2010
    ..plays a minor role), as removal of even one copy of Fgf10 in Gdnf-/-;Spry1-/- mutants causes a complete failure of ureter and kidney development...
  51. ncbi Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
    Nina Perälä
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
    Differentiation 81:81-91. 2011
    ....
  52. ncbi Antagonism of BMP4 signaling disrupts smooth muscle investment of the ureter and ureteropelvic junction
    Gerald J Wang
    Departments of Urology and Physiology and Biophysics ABA, DL, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 181:401-7. 2009
    ..Recent evidence has shown that BMP4 may be involved in ureteral morphogenesis. We determined whether the disruption of BMP4 signaling results in abnormal smooth muscle investment of the ureter and ureteropelvic junction.
  53. pmc Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis
    U Muller
    Department of Physiology, University of California, San Francisco 94143, USA
    Cell 88:603-13. 1997
    ..Consistent with these phenotypes, alpha8 expression is induced in mesenchymal cells upon contact with the ureter. Since none of its previously identified ligands appears likely to mediate the essential functions of alpha8 beta1 ..
  54. ncbi Overexpression of RET leads to vesicoureteric reflux in mice
    O H Yu
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 287:F1123-30. 2004
    ..urinary tract abnormality vesicoureteric reflux (VUR), in which urine flows retrogradely from the bladder to the ureter. Reflux was determined in vitro by injecting methylene blue into the bladders of HoxB7/Ret and wild-type mice...
  55. ncbi Gene discovery and vesicoureteric reflux
    Inga J Murawski
    Department of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Pediatr Nephrol 23:1021-7. 2008
    Vesicoureteric reflux (VUR) is a congenital urinary tract defect caused by abnormal insertion of the ureter within the bladder wall...
  56. ncbi Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase
    Ming Jer Tang
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Dev Biol 243:128-36. 2002
    ..an in vitro organ culture assay, inhibition of PI3K completely blocks the GDNF-dependent outgrowth of ectopic ureter buds. PI3K is also essential for branching morphogenesis once the ureteric bud has invaded the kidney mesenchyme...
  57. ncbi Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development
    R Nishinakamura
    Division of Stem Cell Regulation, Institute of Medical Science, The University of Tokyo, Japan
    Development 128:3105-15. 2001
    ..This phenotype is likely to be primarily caused by the absence of the inductive signal from the ureter, as the Sall1-deficient mesenchyme is competent with respect to epithelial differentiation...
  58. ncbi Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development
    Yoichi Miyazaki
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2584, USA
    Kidney Int 63:835-44. 2003
    We have suggested that bone morphogenetic protein 4 (BMP4), acting on the Wolffian duct and ureter epithelium, determines the budding site of the ureter by locally antagonizing ubiquitous inductive signal(s) from the metanephric ..
  59. pmc Critical and distinct roles for key RET tyrosine docking sites in renal development
    Sanjay Jain
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 20:321-33. 2006
    ..Similar kidney and ureter defects were observed in RET9(Y1015F) mice that contain the Y1015F mutation in the RET9 isoform...
  60. ncbi Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis
    Ihor V Yosypiv
    Department of Pediatrics, Tulane University Health Sciences Center, SL 37, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Am Soc Nephrol 17:1005-14. 2006
    ..This process depends on tyrosine phosphorylation of the EGFR. Cooperation of AT(1)R and EGFR signaling therefore is important in the development of the renal collecting system...
  61. pmc High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma
    David S Hains
    Division of Nephrology, Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA
    J Urol 183:2077-84. 2010
    ..We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux...
  62. pmc Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Am J Physiol Renal Physiol 297:F1208-19. 2009
    ..Furthermore, Frs2alpha may transmit signals through other receptor kinases present in ureteric epithelium. Finally, the renal hypoplasia observed in Frs2alpha(UB-/-) mice is likely secondary to decreased Ret and Wnt11 expression...
  63. ncbi Recurrence and survival following laparoscopic radical nephroureterectomy with various forms of bladder cuff control
    Surena F Matin
    Section of Laparoscopic and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Urol 173:395-400. 2005
    ..We document recurrence and survival following laparoscopic radical nephroureterectomy (LNUX) for upper tract transitional cell carcinoma (TCC) using primarily 2 methods of managing the bladder cuff...
  64. ncbi Inguino-scrotal hernia of a double district ureter: case report and literature review
    L Bertolaccini
    Department of Surgical Activity, Maria Vittoria Hospital, Cibrario St 72, 10149 Turin, Italy
    Hernia 9:291-3. 2005
    ..b>Ureter inguinal hernias are nearly always indirect...
  65. ncbi Comparison of kidney-ureter-bladder abdominal radiography and computed tomography scout films for identifying renal calculi
    Richard Johnston
    Department of Urology, Christchurch Public Hospital, Christchurch, New Zealand
    BJU Int 104:670-3. 2009
    To assess the sensitivity of computed tomography (CT) scout topograms and kidney-ureter-bladder abdominal radiography (KUB) in detecting urinary tract stones.
  66. pmc GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell behaviors
    Frank Costantini
    Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA
    Organogenesis 6:252-62. 2010
    ..Ret signaling, via Etv4 and Etv5, promotes competitive cell rearrangements in the nephric duct, in which the cells with the highest level of Ret signaling preferentially migrate to form the first ureteric bud tip...
  67. ncbi Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation
    M Todd Valerius
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mech Dev 112:219-32. 2002
    ..In situ hybridizations were used to confirm that selected novel genes were expressed in the developing kidney...
  68. ncbi Tomographic quantification of branching morphogenesis and renal development
    Kieran M Short
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Victoria 3800, Australia
    Kidney Int 77:1132-9. 2010
    ..To overcome this, we used optical projection tomography to image and reconstruct the branching ureter epithelium of ex vivo embryonic kidneys and developed software to quantify these three-dimensional (3D) data...
  69. ncbi Severely encrusted polyurethane ureteral stents: management and analysis of potential risk factors
    I Singh
    Department of Urology, All India Institute of Medical Sciences, New Delhi, India
    Urology 58:526-31. 2001
    ..It is important to maintain an efficient computerized stent log under the direct supervision of a physician. Patients with probable risk factors should be monitored even more frequently to avoid mishaps and morbidity...
  70. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
    In the normal mouse embryo, Bmp4 is expressed in mesenchymal cells surrounding the Wolffian duct (WD) and ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously (Alk3) or ..
  71. ncbi Renal and neuronal abnormalities in mice lacking GDNF
    M W Moore
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 382:76-9. 1996
    ..Thus GDNF is important for the development and/or survival of enteric, sympathetic and sensory neurons and the renal system, but is not essential for catecholaminergic neurons in the central nervous system (CNS)...
  72. ncbi Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
    Anissa Pedersen
    Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 288:571-81. 2005
    ..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
  73. ncbi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  74. ncbi Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system
    Kevin T Bush
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, and Urological Diseases Research Center, Department of Urology, Children s Hospital, Boston, MA 02115, USA
    Dev Biol 298:571-84. 2006
    ..apparently normal ureters in the absence of a kidney, suggesting that the growth and development of the unbranched ureter is largely independent of the more proximal portions of the UB which differentiates into the highly branched renal ..
  75. ncbi Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis
    Y Lin
    Biocenter Oulu and Department of Biochemistry, University of Oulu, Oulu, Finland
    Dev Dyn 222:26-39. 2001
    ..kidney demonstrate that cells expressing Wnt-2b are not capable of inducing tubule formation but instead stimulate ureter development. Incubation of isolated ureteric buds on such cells supports bud growth and branching...
  76. pmc Angiotensin II AT2 receptor regulates ureteric bud morphogenesis
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 298:F807-17. 2010
    ..We conclude that AT2R performs essential functions during UB branching morphogenesis via control of the GDNF/c-Ret/Wnt11 signaling pathway, UB cell proliferation, and survival...
  77. ncbi Does the surgical technique for management of the distal ureter influence the outcome after nephroureterectomy?
    Véronique Phé
    Academic Department of Urology of la Pitiè Salpétriére Hospital, Assistance Publique Hopitaux de Paris, Faculte de Medecine Pierre et Marie Curie, University Paris VI, Paris, France
    BJU Int 108:130-8. 2011
    ..Level of Evidence 4 What's known on the subject? and What does the study add? The resection of the distal ureter and its orifice is an oncological principle during radical nephroureterectomy which is based on the fact that it ..
  78. pmc Changes in interstitial cell of Cajal-like cells density in congenital ureteropelvic junction obstruction
    Piotr Koleda
    Department of Pathophysiology, Wroclaw Medical University, ul Marcinkowskiego 1, 50 368 Wroclaw, Poland
    Int Urol Nephrol 44:7-12. 2012
    ..The authors examined the number of interstitial cells of Cajal-like cells (ICC-LCs) in obstructed ureteropelvic junction (UPJ) in comparison with normal UPJ specimens and age-related changes...
  79. ncbi Transvaginal sonography in the morphological and functional assessment of segmental dilation of the distal ureter
    J M Yang
    Division of Urogynecology, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    Ultrasound Obstet Gynecol 27:449-51. 2006
    ..imaging study had revealed a double uterus and obstructed left hemivagina, into which a single vaginal ectopic ureter inserted...
  80. ncbi Pneumovesicum method in en-Bloc laparoscopic nephroureterectomy with bladder cuff resection for upper-tract urothelial cancer
    Chi Wai Cheng
    Urology Team, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    J Endourol 21:359-63; discussion 362-3. 2007
    A novel technique for managing the distal ureter and bladder cuff during laparoscopic nephroureterectomy is introduced.
  81. ncbi Highly predictive survival nomogram after upper urinary tract urothelial carcinoma
    Claudio Jeldres
    Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    Cancer 116:3774-84. 2010
    ....
  82. ncbi Fluoroscopy-guided transurethral removal and exchange of ureteral stents in female patients: technical notes
    Sang Woo Park
    Deparment of Radiology, Konkuk University Hospital, Konkuk University, School of Medicine, 4 12 Hwayang dong, Gwangjin gu, 143 729 Seoul, Republic of Korea
    J Vasc Interv Radiol 18:251-6. 2007
    ..To describe simple and safe techniques for transurethral removal and for exchange of ureteral stents in female patients under fluoroscopic guidance...
  83. ncbi Pediatric robotic extravesical ureteral reimplantation: comparison with open surgery
    Ryan P Smith
    Department of Urology, University of Virginia, Charlottesville, Virginia, USA
    J Urol 185:1876-81. 2011
    ..We review a single surgeon experience and compare the outcomes of robotic assisted laparoscopic extravesical ureteral reimplantation and open ureteral reimplantation in children with vesicoureteral reflux...
  84. ncbi Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction
    R Nørregaard
    The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark
    Kidney Int 70:872-81. 2006
    ..Rats were subjected to bilateral ureter obstruction. Ureters were removed and dissected into a proximal dilated and distal non-dilated segment...
  85. ncbi Rates of urinary tract injury from gynecologic surgery and the role of intraoperative cystoscopy
    D T Gilmour
    Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada
    Obstet Gynecol 107:1366-72. 2006
    ..To estimate the rates of urinary tract injury after benign gynecologic surgery. To explore the role of routine intraoperative cystoscopy at benign gynecologic surgery...
  86. ncbi Double ureter and duplex system: a cadaver and radiological study
    - Prakash
    Department of Anatomy, Vydehi Institute of Medical Sciences and Research Center, Karnataka, India
    Urol J 8:145-8. 2011
    To study the prevalence of duplex system and double ureter in cadavers and intravenous pyelograms in Indian population.
  87. ncbi A sealed bladder cuff technique during laparoscopic nephroureterectomy utilizing the LigaSure electrosurgical device: laboratory and clinical experience
    Erica H Lambert
    Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Endourol 24:327-32. 2010
    ..Controversy exists over the optimal technique for the distal ureter and bladder cuff (DUBC) excision...
  88. ncbi Morphology, calcium signaling and mechanical activity in human ureter
    Rachel V Floyd
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
    J Urol 180:398-405. 2008
    We determined the mechanisms of calcium signaling in the human ureter, and the relationship to peristaltic contractions and bundular structure in living tissue, thereby advancing the understanding of ureteral function in health and ..
  89. ncbi Laparoscopic radical nephroureterectomy with en-bloc distal ureteral and bladder cuff excision using a single position pneumovesicum method
    Thomas J Guzzo
    The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:850-2. 2008
    We describe a completely laparoscopic approach for en-bloc dissection of the distal ureter and bladder cuff during nephroureterectomy using a pneumovesicum approach and with the need for intraoperative patient repositioning...
  90. ncbi Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction
    Fabio Bartoli
    Division of Pediatric Surgery, University of Foggia, Foggia, Italy
    J Pediatr Surg 46:530-6. 2011
    ..The aim of this study is to evaluate the urinary excretion of these cytokines and β2-microglobulin (β2M) in children with urine flow impairment at the ureteropelvic junction or who underwent pyeloplasty...
  91. ncbi Propagation characteristics of the electrical impulse in the normal and obstructed ureter as determined at high electrophysiological resolution
    Fayez T Hammad
    Department of Surgery, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    BJU Int 108:E36-42. 2011
    ..To investigate the propagation of the electrical impulses in a unilateral ureteric obstruction model using a high-resolution technique in vivo...
  92. pmc GLI3 repressor controls functional development of the mouse ureter
    Jason E Cain
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Invest 121:1199-206. 2011
    ..forms of hydronephrosis (increased diameter of the renal pelvis and calyces) and hydroureter (dilatation of the ureter) are the most frequently detected antenatal abnormalities, yet the underlying molecular mechanisms are largely ..
  93. ncbi Endometriosis of ureter-induced recurrent urinary tract infections in a premenopausal woman--case report
    K Stamatiou
    Department of Urology, Tzaneion General Hospital, Piraeus, Greece
    Clin Exp Obstet Gynecol 34:63-4. 2007
    ..The ureters and kidneys are the least usual place of localization. Endometriosis of the ureter often leads to silent loss of renal function due to delayed diagnosis...
  94. pmc Effects of a non-selective COX inhibitor and selective COX-2 inhibitors on contractility of human and porcine ureters in vitro and in vivo
    V Chaignat
    Division of Veterinary Pharmacology and Toxicology, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty Berne, University of Berne, Berne, Switzerland
    Br J Pharmacol 154:1297-307. 2008
    ..COX-1 and COX-2 receptors were identified in human ureter and kidney.
  95. ncbi Pharmacologic manipulation of the porcine ureter: Acute impact of topical drugs on ureteral diameter and peristaltic activity
    Caroline D Ames
    Department of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Endourol 20:943-8. 2006
    ..We characterized the in-vivo effects of intraluminal application of verapamil and theophylline on ureteral peristalsis and diameter in a porcine model...
  96. ncbi Prospective long-term analysis of nerve-sparing extravesical robotic-assisted laparoscopic ureteral reimplantation
    Sanjay Kasturi
    Department of Surgery, Division of Urology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Urology 79:680-3. 2012
    ....
  97. ncbi Decellularized ureter for tissue-engineered small-caliber vascular graft
    Yuji Narita
    Department of Clinical Cell Therapy and Tissue Engineering, Nagoya University School of Medicine, Nagoya, 466 8550, Japan
    J Artif Organs 11:91-9. 2008
    ..These results suggest that tissue-engineered DUs may be a potential alternative conduit for bypass surgery...
  98. ncbi Changes in the urine composition during its passage through the ureter. A concept of urothelial function
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Urol Res 33:426-8. 2005
    ..Based on this concept, we investigated the hypothesis that urine undergoes changes during its passage in the ureter. Urine samples were separately collected from the renal pelvis and ureters of 23 volunteers (15 men, eight women, ..
  99. ncbi Abnormalities in ureter and kidney development in mice given acetazolamide-amiloride or dimethadione (DMO) during embryogenesis
    T A Miller
    Children s Hospital Research Foundation, Cincinnati, Ohio
    Teratology 46:541-50. 1992
    ..or a single dose of dimethadione (DMO), the active metabolite of trimethadione, on the development of the ureter. When acetazolamide-amiloride was administered in C57BL/6NCrlBR mice on day 9, 9...
  100. ncbi Retroperitoneal laparoscopic radical nephrectomy and nephroureterectomy and comparison with open surgery
    Apul Goel
    All India Institute of Medical Sciences, Department of Urology, Ansari Nagar, New Delhi, 110 029 India
    World J Urol 20:219-23. 2002
    ..An oncologically complete removal of the tumour is possible as in open surgery. The retroperitoneoscopic approach is associated with less morbidity and faster recovery...
  101. ncbi A novel technique for ureteral catheterization and/or retrograde ureteroscopy after cross-trigonal ureteral reimplantation
    M Chad Wallis
    Section of Urology, Columbus Children s Hospital, Ohio 43205, USA
    J Urol 170:1664-6; discussion 1666. 2003
    A criticism of the Cohen cross-trigonal reimplantation is the potential difficulty of retrograde access to the ureter. With the advent of modern endourological equipment, we devised a novel technique that obviates the aforementioned ..

Research Grants68

  1. Mechanisms of Renoprotection by Soluble Epoxide Hydrolase Inhibition
    Deanna L Kroetz; Fiscal Year: 2013
    ..The renoprotective properties of sEH inhibition will be studied in both a unilateral ureter ligation model and in ischemia/reperfusion...
  2. Transcriptional mechanisms of lower urinary tract development
    Gerald Mingin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Congenital abnormalities of the upper (kidney) and lower (ureter, bladder, urethra and external genitalia) urinary tracts are diagnosed at a rate of 1 in 500 prenatal ultrasounds...
  3. Clinical Outcomes for Siblings of Children with Vesico-Ureteral Reflux
    CALEB PENNELL NELSON; Fiscal Year: 2013
    ..VUR is the retrograde flow of urine from the bladder into the ureter and kidney, and is associated with urinary tract infection (UTI) and renal injury...
  4. Vitamin A dependent events in urinary tract formation.
    Cathy Mendelsohn; Fiscal Year: 2009
    ..stages of urogenital tract formation, in the kidney for branching morphogenesis and in the common nephric duct for ureter transposition...
  5. DLGH1 AND UROGENITAL DEVELOPMENT
    WOJCIECH A SWAT; Fiscal Year: 2012
    ..studies show that DLGH1 is expressed strongly in the urothelium and weakly in other cells of the ureter. We will determine which cellular compartment must express Dlgh1 for normal smooth muscle cell alignment and for ..
  6. Molecular Events in Urinary Tract Formation
    CATHY LEE MENDELSOHN; Fiscal Year: 2012
    ..The bladder and urethra form independently of the kidney and ureter, connecting at midgestation to form a patent outflow tract...
  7. Molecular Pathogenesis of Vesicoureteral Reflux
    Weining Lu; Fiscal Year: 2012
    ..Lastly, given the abnormal ureteric branching and ureter elongation defects in Robo2 deficient mice and substantial actions of Robo/Slit signaling in neural development, ..
  8. Urogenital System Development: The Acquisition of Coordinated Ureter Peristalsis
    Doris A Herzlinger; Fiscal Year: 2013
    ..of the smooth muscle coat surrounding the kidney outflow tract (OT), including the renal calyces, pelvis and ureter, are essential for draining urine out of the kidney...
  9. NEW INSIGHTS INTO ROLE OF RET IN UROGENITAL DEVELOPMENT AND ANOMALIES
    Sanjay Jain; Fiscal Year: 2013
    ..Ret reporter and RetY1015F mice to delineate abnormalities in the anterior Wolffian duct, UB position and distal ureter maturation that lead to CAKUT-like defects in these mice...
  10. Biochemical and Functional Studies of Sall1 in Kidney Development and TBS
    MICHAEL I RAUCHMAN; Fiscal Year: 2010
    ..These mice display renal hypoplasia with reduced branching of the ureter, similar to that seen in TBS patients...
  11. Genetic Control of Ureter and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..alterations in the normal processes of ureteric bud induction, growth, and branching during the development of the ureter and the renal collecting duct system...
  12. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..and will continue to do so) expression profilng data from across time and space in the developing kidney and ureter. Hence we have defined a set of approximately 2500 genes tht we know are involved in UGT development...
  13. Branching Morphogenesis of Urinary Epithelia: from Genes to Cellular Behaviors
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..of a single ureteric bud (UB) at the proper location on the Wolffian duct (WD) is important to make a functional ureter, while complex patterns of UB branching morphogenesis are required for normal renal organogenesis...
  14. Surgical Laser device development for precise or bulk ablation of urologic tissue
    Jonathon D Wells; Fiscal Year: 2010
    ..Surgical lasers form the standard of care for many treatments and endoscopic procedures in the prostate, kidney, ureter, bladder, and urethra...
  15. Computer-Aided Detection of Urinary Tract Cancer on MDCT Urography
    LUBOMIR M HADJIYSKI; Fiscal Year: 2013
    ..In order to accomplish these tasks, we will develop new image analysis techniques for automated tracking of the ureter and segmentation of the inner and outer walls of the bladder and the ureter...
  16. A genetic model of vesicoureteral reflux and reflux nephropathy
    CARLTON MATTHEW BATES; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vesicoureteral reflux (VUR- backflow of urine from the bladder into the ureter) is the most common urogenital anomaly in children and reflux nephropathy is the 4th leading cause of chronic renal ..
  17. Roles of transcription factors in kidney development
    Pin Xian Xu; Fiscal Year: 2012
    ..MM), the outgrowth of the ureteric bud (UB), and its correctly patterned branching morphogenesis to generate the ureter and the renal collecting system...
  18. Ureteric Bud Patterning
    Doris A Herzlinger; Fiscal Year: 2013
    ..morphogenesis forming the intra-renal collecting system whereas its distal or trunk domain differentiates into the ureter. Abnormal regulation of ureteric bud morphogenesis can result in a spectrum of congenital defects, the most common ..
  19. Staging of upper tract urothelial cancer with optical coherence tomography
    Hui Zhu; Fiscal Year: 2013
    ..tissue specimens for pathohistological staging cannot be acquired because of the limited manipulation space in the ureter and renal pelvis and the potential risk of perforating thin ureteral wall if deep biopsyis attempted...
  20. FLORIDA FIREFIGHTER CANCER INCIDENCE AND MORTALITY
    Lora Fleming; Fiscal Year: 2001
    ..Excess mortality for cancer of the lung, kidney and ureter, rectum and colon, and skin has also been reported...
  21. Optimizing anti-virulence compounds for the treatment of UTIs
    SARAH ELIZABETH GREENE; Fiscal Year: 2013
    ..pili and the function of pilicides in host-like environments, such as after growth in urine or attachment to human ureter tissue. We also have evidence that pilicides have other effects on UPEC in addition to disrupted pilus assembly...
  22. Strategies for Improved Shock Wave Lithotripsy
    JAMES ALEXANDER MCATEER; Fiscal Year: 2013
    ..from SWL adverse effects * Determine the properties of SWs at their site of action in the kidney and proximal ureter * Increase the efficiency of SWL by improving the acoustic coupling between the lithotripter and the patient * ..
  23. 3D atlas & database of murine urogenital development
    Richard Baldock; Fiscal Year: 2010
    ..anatomical ontology, a catalogue of cell types and a quantitative morphological description of mouse kidney, ureter and bladder development, which will provide a baseline for future studies that examine the effects of experimental ..
  24. Regulaton of Urothelial Growth
    Tung Tien Sun; Fiscal Year: 2007
    The luminal surface of the entire lower urinary tract including renal pelvis, ureter, bladder and proximal urethra is lined by a cell type described in standard textbooks as the transitional epithelium or urothelium, which is ..
  25. Elastic biodegradable ureteral stent
    Haesun Park; Fiscal Year: 2009
    ..There are many surgical procedures that require the emplacement of a ureteral stent. The ureter is a tube that allows urine to flow from the kidney to the bladder...
  26. POPULATION BASED STUDY OF LOWER URINARY TRACT TUMORS
    Loraine Marrett; Fiscal Year: 1980
    ..of bladder tumor (BT) and other lower urinary tract tumors (LUTT), including tumors of the renal pelvis, ureter, and urethra...
  27. CONFERENCE ON GENOMIC INSTABILITY AND DYSREGULATION
    Charles Fox; Fiscal Year: 1991
    ..Bubbles will be generated in the renal artery, parenchyma, collecting system, ureter, vena cava and in the urinary bladder (a relatively easy site suitable for evaluation of reflux and as part of a ..
  28. Transcriptional regulation of bladder-ureter development
    H Stadler; Fiscal Year: 2007
    ..GS) Syndromes, two autosomal dominant disorders that profoundly affect the development of the limb, bladder, ureter, uterus, and external genitalia...
  29. ENHANCING BRAIN UPTAKE OF AZT BY TRANSPORT INHIBITION
    Ronald Sawchuk; Fiscal Year: 1991
    ..Additional experiments will be performed in ureter- cannulated animals to characterize renal clearance of AZT as a function of plasma concentration of inhibitor...
  30. HOXA 13 REGULATION OF GENITOURINARY DEVELOPMENT
    H Stadler; Fiscal Year: 2002
    ..prostate, uterine, Mullerian duct, vaginal bladder, ureter. and rectal defects...
  31. Urothelial Differentiation in Interstitial Cystitis
    Monica Liebert; Fiscal Year: 2004
    ..Normal urothelial cells will be harvested from urothelial tissues (bladder or ureter) and evaluated by flow cytometry, immunostaining, RT-PCR and Northern and Western blotting for expression of a ..
  32. Calcineurin in Congenital Nephropathy
    Feng Chen; Fiscal Year: 2004
    ..These mice have deletion of CnB in the excretory system, including the smooth muscle cells in the ureter. The affected mice have hydronephrosis and hydroureter and die from postnatal renal failure...
  33. A New Transgenic Approach for the Kidney
    Pumin Zhang; Fiscal Year: 2004
    The development of the mammalian kidney is a very complex process, involving branching morphogenesis of the ureter and the formation of nepherons...
  34. Fox genes in urinary tract development
    Tsutomu Kume; Fiscal Year: 2005
    ..that the impairment of embryonic steps, the ureteric budding and differentiation of smooth muscle around the ureter, leads to urinary tract abnormalities such as hydroureter and hydronephrosis...
  35. CELL INTERACTIONS IN DEVELOPMENT OF THE MAMMALIAN KIDNEY
    Andrew McMahon; Fiscal Year: 2007
    ..expression is positioned just beneath the branch tips while that of Wnt7b is more distal and extends into the ureter. We have generated mutant alleles that allow the conditional removal of Wnt l5 and Wnt7b activities and we will ..
  36. Genetic Determinants of Vesicoureteral Reflux
    Ali Gharavi; Fiscal Year: 2007
    ..Identification of the gene(s) for VUR will provide insight in the biology of ureter and bladder development...
  37. Generation /Analysis of Mice Carrying GFP-tagged Genes in Kidney Development
    Pumin Zhang; Fiscal Year: 2009
    ..The development of the mammalian kidney is a very complex process, involving branching morphogenesis of the ureter and the formation of nepherons...
  38. Identification of Genes Regulating Ureter Morphogenesis
    Sanjay Nigam; Fiscal Year: 2007
    The ureter develops out of the ureteric bud (UB), but most work on the UB to date has focused on branching morphogenesis as it relates to development of the kidney collecting ducts...
  39. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004
    ..into the omentum for vascularisation, together with reconnection to the excretory tract via a replacement ureter. Endogenous renal repair would involve the reintroduction and integration of induced and isolated renal progenitor ..
  40. Gene transfer to the kidney using lentiviral vectors
    Frank Park; Fiscal Year: 2004
    ..to be elucidated, and so we propose to inject lentiviral vectors through different routes: the renal artery, the ureter or directly into the renal interstitium...
  41. BIOMEDICAL ENGINEERING CENTER FOR POLYMER IMPLANTS
    Donald Lyman; Fiscal Year: 1980
    ..The associated projects include Ureter and Bladder Repair, Development of Small Diameter Vascular Prostheses, Development of Polymeric Nerve Prostheses, ..
  42. TRANSCRIPTIONAL CONTROL OF KIDNEY MORPHOGENESIS
    Eseng Lai; Fiscal Year: 2000
    ..the nephrogenic mesenchyme is inhibited, as is the growth and branching of the collecting system and growth of the ureter. These studies suggested that interactions between the stromal mesenchyme and the developing epithelial components ..
  43. PATHOGENIC MECHANISMS OF IC
    Ada Elgavish; Fiscal Year: 1993
    ..Using epitheilial and fibroblast cell cultures we isolate from the urinary bladder and the ureter, we propose a carefully developed plan to begin sorting out mechanisms which are likely to be involved in the ..
  44. DEVELOPMENT OF THE URINARY COLLECTING SYSTEM
    Sanjay Nigam; Fiscal Year: 2003
    ..We aim to characterize their: 1) spatiotemporal patterns of expression during development of the ureter and collecting ducts (Northerns, in situ hybridization, immunohistochemistry); 2) clone and sequence any novel ..
  45. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2001
    ..Finally, new types of mutants and transgenic mice will be generated to study the role of Fused in mouse embryogenesis. ..
  46. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2007
    ..abstract_text> ..
  47. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  48. CYTOKINES CONVERT EPITHELIAL PRECURSORS TO NEPHRONS
    Jonathan M Barasch; Fiscal Year: 2010
    ..We apply the basic ideas and tools of cell biologyto define the course of polarization and establish a fluorescent polarity mouse to evaluate the entire transition form mesenchyme to epithelia. ..
  49. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  50. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..This project will determine the prevalence of RANTES as a novel IC biomarker in urines and then quantify the efficacy of mechanistically-directed therapies in murine models. ..
  51. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  52. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..This study would be the first large-scale comprehensive description of collagen cross-linking, lysine hydroxylation, and of genes coding for enzymes involved in the cross-linking process, in patients with pelvic organ prolapse. ..
  53. TNF Mediates Obstruction-Induced Renal Injury
    KIRSTAN MELDRUM; Fiscal Year: 2008
    ..and enhance the knowlegde gained by the applicant during her residency and fellowship training to develop a clinically relevant therapeutic approach to the treatment and prevention of obstructive renal injury [unreadable] [unreadable]..
  54. Membrane Organisation by Tetraspanins and Small Multi-transmembrane
    Tung Tien Sun; Fiscal Year: 2006
    ..abstract_text> ..
  55. The Role of Bone Morphogenetic Protein-7 in Renal Endothelial Cell Biology
    Jeremiah Morrissey; Fiscal Year: 2008
    ..000 for each patient. This proposal examines a treatment designed to delay or halt the progression of renal disease thereby saving a significant portion of the yearly Medicare budget. [unreadable] [unreadable] [unreadable]..
  56. Immune Response to Polyomavirus Infection
    Parmjeet S Randhawa; Fiscal Year: 2010
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
  57. 2nd International Cervical Cancer Conference
    Michele Follen; Fiscal Year: 2002
    ..Each session chair and speaker has been chosen based on his/her publications, funding and national reputation. ..
  58. Differentiation of ES Cells into Renal Epithelia
    Gregory Dressler; Fiscal Year: 2006
    ..Since ES cells potentially represent an unlimited supply of renal progenitors, these experiments will lay the foundation for cell based therapies to improve the efficacy of ATN treatment. ..
  59. Cesarean After Sphincter Tear (CAST) RCT Planning Grant
    Anthony Visco; Fiscal Year: 2005
    ..The upfront investment of time and resources will result in the submission of an efficient and well-designed R01 application that can be implemented in a timely fashion. ..
  60. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Peripheral Arterial Disease and Leg Muscle Metabolism
    LOIS KILLEWICH; Fiscal Year: 2005
    ..It is my ultimate hope that the combined interventions of bypass surgery and nutritional supplementation with amino acids can be used to improve overall functional status of these elderly Americans. ..
  62. Race Differences in Female UI: Epidemiology and Biology
    John DeLancey; Fiscal Year: 2005
    ..Knowledge of these factors can then provide the basis for risk factor identification and the development of preventive strategies appropriate to different racial groups. ..
  63. Cell Signaling in Developing Epithelia
    Gregory R Dressler; Fiscal Year: 2010
    ..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..
  64. Role of polycystin-1 in centrosome duplication and cell cycle control
    GABRIELE LUCA GUSELLA; Fiscal Year: 2010
    ..Our study will contribute to ongoing efforts assessing the therapeutic potential for cell cycle inhibitors in the treatment of ADPKD. ..
  65. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  66. STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLs
    Stephen Nakada; Fiscal Year: 2005
    ..While the specific model of this proposal involves urothelial cells cultured from the ureter, this novel concept has broad implications in the pathophysiology of the urinary tract...