nephrons

Summary

Summary: The functional units of the kidney, consisting of the glomerulus and the attached tubule.

Top Publications

  1. ncbi Epithelial Na(+) channels are regulated by flow
    L M Satlin
    Department of Pediatrics, Mount Sinai School of Medicine, New York 10029 6574, USA
    Am J Physiol Renal Physiol 280:F1010-8. 2001
  2. ncbi Compensatory renal growth after unilateral nephrectomy in the ovine fetus
    Rebecca Douglas-Denton
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    J Am Soc Nephrol 13:406-10. 2002
  3. ncbi Glomeruli and blood pressure. Less of one, more the other?
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115
    Am J Hypertens 1:335-47. 1988
  4. ncbi Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons
    Takashige Kuwabara
    Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Kidney Int 75:285-94. 2009
  5. ncbi Nephron sparing surgery for renal tumors: indications, techniques and outcomes
    R G Uzzo
    Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Urol 166:6-18. 2001
  6. ncbi Long-term outcomes after nephron sparing surgery for renal cell carcinoma larger than 4 cm
    Matthieu Peycelon
    Department of Urology, Groupement Hospitalier Universitaire Est Pitié Tenon, Assistance Publique Hôpitaux de Paris and Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France
    J Urol 181:35-41. 2009
  7. pmc Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
    Hui Teng Cheng
    Department of Molecular Biology and Pharmacology at Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    Development 134:801-11. 2007
  8. ncbi Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2
    V Hatini
    Cell Biology Program and Division of Endocrinology, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 10:1467-78. 1996
  9. ncbi Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study
    R Mañalich
    National Institute of Nephrology, National Referral Center for Pathology, and González Coro Gynecology Obstetric Hospital, Havana, Cuba
    Kidney Int 58:770-3. 2000
  10. ncbi Normal lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat
    Mary E Wlodek
    Department of Physiology, University of Melbourne, Parkville 3010, Australia
    J Am Soc Nephrol 18:1688-96. 2007

Research Grants

  1. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
  2. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
  3. Mechanism of Gene Repression in the Kidney
    Sanjeevkumar R Patel; Fiscal Year: 2013
  4. Genetic Analysis of Etv4/Etv5 Transcription Factors and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
  5. Role of Par1 Polarity Proteins in Podocyte Development and Glomerular Disease
    KIMBERLY JEAN REIDY; Fiscal Year: 2013
  6. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
  7. AT1 Receptors in Renal Microvascular Physiology
    LISA HARRISON BERNARD; Fiscal Year: 2009
  8. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    Thomas L Pallone; Fiscal Year: 2013
  9. The Role of p120 Catenin in Metanephric Kidney Development
    DENISE K MARCIANO; Fiscal Year: 2012
  10. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009

Detail Information

Publications303 found, 100 shown here

  1. ncbi Epithelial Na(+) channels are regulated by flow
    L M Satlin
    Department of Pediatrics, Mount Sinai School of Medicine, New York 10029 6574, USA
    Am J Physiol Renal Physiol 280:F1010-8. 2001
    ..We propose that intraluminal flow rate may be an important regulator of channel activity in the CCD...
  2. ncbi Compensatory renal growth after unilateral nephrectomy in the ovine fetus
    Rebecca Douglas-Denton
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    J Am Soc Nephrol 13:406-10. 2002
    ..nephrectomy of the adult animal results in compensatory renal growth but does not involve formation of new nephrons. It is not clear whether compensatory growth can occur during the period of active nephrogenesis in utero and if ..
  3. ncbi Glomeruli and blood pressure. Less of one, more the other?
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115
    Am J Hypertens 1:335-47. 1988
    ..a renal abnormality that contributes to essential hypertension in the general population is a reduced number of nephrons. The consequences of this abnormality are limitations in the ability to excrete sodium and thus, salt-sensitive ..
  4. ncbi Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons
    Takashige Kuwabara
    Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Kidney Int 75:285-94. 2009
    ..Our study shows that the urinary Ngal level may be useful for monitoring the status and treatment of diverse renal diseases reflecting defects in glomerular filtration barrier, proximal tubule reabsorption, and distal nephrons.
  5. ncbi Nephron sparing surgery for renal tumors: indications, techniques and outcomes
    R G Uzzo
    Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Urol 166:6-18. 2001
    ..Accumulating data in appropriately select patients suggest a long-term functional advantage gained by the maximal preservation of unaffected renal parenchyma without sacrificing cancer control...
  6. ncbi Long-term outcomes after nephron sparing surgery for renal cell carcinoma larger than 4 cm
    Matthieu Peycelon
    Department of Urology, Groupement Hospitalier Universitaire Est Pitié Tenon, Assistance Publique Hôpitaux de Paris and Faculté de Médecine Pierre et Marie Curie, University Paris VI, Paris, France
    J Urol 181:35-41. 2009
    ..We determined the cancer control provided by nephron sparing surgery for renal cell carcinoma greater than 4 cm...
  7. pmc Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
    Hui Teng Cheng
    Department of Molecular Biology and Pharmacology at Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    Development 134:801-11. 2007
    ..These results establish distinct (non-redundant), instructive roles for Notch receptors in nephron segmentation...
  8. ncbi Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2
    V Hatini
    Cell Biology Program and Division of Endocrinology, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 10:1467-78. 1996
    ..reveals a smaller collecting system, numerous large condensations of mesenchyme, and a decrease in the number of nephrons. Using molecular markers we show that induction and condensation of the nephrogenic mesenchyme occurs normally in ..
  9. ncbi Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study
    R Mañalich
    National Institute of Nephrology, National Referral Center for Pathology, and González Coro Gynecology Obstetric Hospital, Havana, Cuba
    Kidney Int 58:770-3. 2000
    The number of nephrons in humans varies considerably under normal circumstances, and retarded intrauterine growth has been reported to be associated with a significant reduction in nephron number...
  10. ncbi Normal lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat
    Mary E Wlodek
    Department of Physiology, University of Melbourne, Parkville 3010, Australia
    J Am Soc Nephrol 18:1688-96. 2007
    ..It is shown for the first time that a prenatally induced nephron deficit can be restored by correcting growth restriction during lactation...
  11. ncbi Renal progenitors: an evolutionary conserved strategy for kidney regeneration
    Paola Romagnani
    Pediatric Nephrology Unit, Meyer Children s Hospital, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy
    Nat Rev Nephrol 9:137-46. 2013
    ..Understanding the mechanisms that drive renal progenitor growth and differentiation represent the key step for modulating this potential for therapeutic purposes...
  12. pmc A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney
    Jing Yu
    Department of Molecular and Cellular Biology and Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:161-71. 2009
    ..These findings demonstrate that Wnt7b is a key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney...
  13. ncbi Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans
    Thomas Guldager Lauridsen
    Department of Medicine, Department of Medical Research, Regional Hospital Holstebro, Lagaardvej 12, Holstebro, Denmark
    Nephrol Dial Transplant 25:2502-10. 2010
    ....
  14. pmc FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man
    Hila Barak
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    Dev Cell 22:1191-207. 2012
    ..These findings identify a long-sought-after critical component of the nephron stem cell niche and hold promise for long-term culture and utilization of these progenitors in vitro...
  15. ncbi The epithelial sodium channel and the control of sodium balance
    Laurent Schild
    Departement de Pharmacologie and Toxicologie, Universite de Lausanne, Lausanne, Switzerland
    Biochim Biophys Acta 1802:1159-65. 2010
    ..These in vivo physiological studies presently constitute a major challenge for our understanding of the regulation of ENaC to maintain the Na(+) balance...
  16. ncbi Pathways to nephron loss starting from glomerular diseases-insights from animal models
    Wilhelm Kriz
    Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 67:404-19. 2005
    ..of chronic renal disease is underlain by a vicious cycle which passes on the damage from lost and/or damaged nephrons to so far healthy nephrons...
  17. pmc Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model
    Michael S Forbes
    Dept of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 301:F110-7. 2011
    ....
  18. ncbi Human nephron number: implications for health and disease
    John F Bertram
    Department of Anatomy and Developmental Biology, Monash University Clayton, Melbourne, Victoria, 3800, Australia
    Pediatr Nephrol 26:1529-33. 2011
    ..1 million. Given that no new nephrons are formed in human kidneys after approximately 36 weeks' gestation, much interest has focused on renal function ..
  19. pmc A common RET variant is associated with reduced newborn kidney size and function
    Zhao Zhang
    McGill University Health Centre Research Institute, Montreal Quebec, Canada
    J Am Soc Nephrol 19:2027-34. 2008
    ..Whether this gene variant affects clinical outcomes requires further study...
  20. ncbi Nephron number in patients with primary hypertension
    Gunhild Keller
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    N Engl J Med 348:101-8. 2003
    A diminished number of nephrons has been proposed as one of the factors contributing to the development of primary hypertension.
  21. ncbi Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
    I A Drummond
    Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
    Development 125:4655-67. 1998
    ..The pronephros consists of two nephrons with fused glomeruli and paired pronephric tubules and ducts...
  22. pmc Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
    Akio Kobayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell Stem Cell 3:169-81. 2008
    b>Nephrons, the basic functional units of the kidney, are generated repetitively during kidney organogenesis from a mesenchymal progenitor population...
  23. pmc Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development
    Courtney M Karner
    Department of Internal Medicine Nephrology and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA
    Development 138:1247-57. 2011
    The mammalian kidney is composed of thousands of individual epithelial tubules known as nephrons. Deficits in nephron number are associated with myriad diseases ranging from complete organ failure to congenital hypertension...
  24. ncbi Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury
    M Tanaka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Kidney Int 73:181-91. 2008
    ..Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome...
  25. ncbi Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros
    Yan Liu
    Nephrology Division, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Development 134:1111-22. 2007
    ....
  26. pmc Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney
    Joshua W Mugford
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 324:88-98. 2008
    ..These studies provide new insights into the cellular origins of metanephric kidney structures and lend support to a model where Osr1 function is limited to establishing the nephron progenitor pool...
  27. ncbi Early glomerular alterations in genetically determined low nephron number
    Kerstin Benz
    Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 300:F521-30. 2011
    ....
  28. pmc Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
    Dev Dyn 240:240-9. 2011
    ..Beyond E12.5, Fgfr1(Mes-/-)Fgfr2IIIc-/- mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development...
  29. ncbi Low birth weight is associated with reduced nephron number and increased blood pressure in adulthood in a novel spontaneous intrauterine growth-restricted model in Yucatan miniature Swine
    Semone B Myrie
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Nfld, Canada
    Neonatology 100:380-6. 2011
    ..Impaired fetal growth and rapid postnatal growth are associated with programming of hypertension and metabolic syndrome in adulthood...
  30. pmc BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism
    Ulrika Blank
    Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Development 136:3557-66. 2009
    The iterative formation of nephrons during embryonic development relies on continual replenishment of progenitor cells throughout nephrogenesis...
  31. ncbi Prenatal programming of nephron number and blood pressure
    M F Schreuder
    Department of Pediatric Nephrology, Erasmus MC Sophia Children s Hospital, University Medical Center, Rotterdam, The Netherlands
    Kidney Int 72:265-8. 2007
    ..this reduction in renal mass is supposed to lead to glomerular hyperfiltration and hypertension in remnant nephrons with subsequent glomerular injury with proteinuria, systemic hypertension and glomerulosclerosis...
  32. ncbi Nephron-sparing surgery for localized renal cell carcinoma with a normal contralateral kidney: a European three-center experience
    Dimitrios Delakas
    Department of Urology, General University Hospital of Heraklion, Crete, Greece
    Urology 60:998-1002. 2002
    ..To assess the long-term effectiveness and safety of nephron-sparing surgery for the treatment of localized renal cell carcinoma with a normal contralateral kidney...
  33. ncbi Regulation of extracellular fluid volume and blood pressure by pendrin
    Juliette Hadchouel
    INSERM UMRS 970 Paris Cardiovascular Research Center PARCC, Paris, France
    Cell Physiol Biochem 28:505-12. 2011
    ....
  34. ncbi Oligonephropathy of prematurity
    Yogavijayan Kandasamy
    Department of Neonatology, The Townsville Hospital, Douglas, Queensland, Australia
    Am J Perinatol 29:115-20. 2012
    ..The cost implications to a comprehensive program, impact of early identification, and strategies to improve outcomes in this population are needed...
  35. ncbi Independent regulation of Na+ and K+ balance by the kidney
    María Castañeda-Bueno
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto Nacional de Cardiologia Ignacio Chavez, and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Med Princ Pract 21:101-14. 2012
    ....
  36. pmc Effects of early postnatal hyperglycaemia on renal cortex maturity, endothelial nitric oxide synthase expression and nephron deficit in mice
    Ana Rosa Cunha
    Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
    Int J Exp Pathol 89:284-91. 2008
    ....
  37. ncbi Positive surgical margins with renal cell carcinoma have a limited influence on long-term oncological outcomes of nephron sparing surgery
    Orit Raz
    Department of Urology, Assaf Harofeh Medical Center, Zerifin, Israel
    Urology 75:277-80. 2010
    ..The outcome and proper management of patients with positive PSMs during nephron sparing surgery (NSS) are questionable. In this study we define the clinical outcomes of PSMs at NSS and suggest management...
  38. ncbi Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
    Yumiko Kiuchi-Saishin
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yonoe Koshida, Sakyo ku, Kyoto 606, Japan
    J Am Soc Nephrol 13:875-86. 2002
    ..first step in understanding the physiologic functions of claudins (tight junction integral membrane proteins) in nephrons, the expression of claudin-1 to -16 in mouse kidneys was examined by Northern blotting...
  39. ncbi TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis
    S Y Plisov
    Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD 21702, USA
    Development 128:1045-57. 2001
    ....
  40. ncbi FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons
    Uta Grieshammer
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 132:3847-57. 2005
    During kidney morphogenesis, the formation of nephrons begins when mesenchymal nephron progenitor cells aggregate and transform into epithelial vesicles that elongate and assume an S-shape...
  41. ncbi Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep
    Stephen P Gray
    Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800 Australia
    Am J Physiol Regul Integr Comp Physiol 295:R568-74. 2008
    ..A reduced nephron endowment of this magnitude could have important implications for the cardiovascular health of offspring during postnatal life...
  42. ncbi Postnatal food restriction in the rat as a model for a low nephron endowment
    Michiel F Schreuder
    Dept of Pediatric Nephrology, VU Univ Medical Ctr, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Renal Physiol 291:F1104-7. 2006
    ..Nephrogenesis is the process that leads to the formation of nephrons until week 36 of gestation in humans and may be inhibited by many factors like intrauterine growth restriction ..
  43. pmc Very low birth weight is a risk factor for secondary focal segmental glomerulosclerosis
    Jeffrey B Hodgin
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Clin J Am Soc Nephrol 4:71-6. 2009
    ..LBW is associated with reduced nephron endowment and increased glomerular volume; however, the development of secondary focal segmental glomerulosclerosis (FSGS) has not been reported previously...
  44. ncbi Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis
    Tino D Piscione
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, Ont, Canada M5G 1X8
    Gene Expr Patterns 4:707-11. 2004
    ..e. pre-tubular aggregates), but demonstrate distinct expression patterns in early nephrons (i.e...
  45. ncbi Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney
    Eman Naim
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    Kidney Int 68:955-65. 2005
    ..The aim of this study was to investigate the role of the epithelial polarity gene, discs large 1 (dlg1), during development of the mouse kidney...
  46. pmc The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage
    Kameswaran Surendran
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 337:386-95. 2010
    ....
  47. ncbi Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep
    Reetu R Singh
    Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia
    Clin Sci (Lond) 118:669-80. 2010
    ..We hypothesized this may be attributable to impaired sodium homoeostasis by the remaining nephrons. The present study investigated whether a nephron deficit, induced by fetal uninephrectomy at 100 days gestation (..
  48. pmc Maternal diabetes modulates renal morphogenesis in offspring
    Stella Tran
    University of Montreal, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Research Centre, Montreal, Quebec, Canada
    J Am Soc Nephrol 19:943-52. 2008
    ..In conclusion, maternal diabetes impairs nephrogenesis, possibly via enhanced intrarenal activation of the renin-angiotensin system and NF-kappaB signaling...
  49. ncbi Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule
    Martin Y H Zhang
    Department of Pediatrics, University of California, San Francisco, California 94143, USA
    Endocrinology 143:587-95. 2002
    ..The increase in P450c1alpha gene expression, which occurs exclusively in the proximal renal tubule, is due at least in part to increased transcription of the P450c1alpha gene...
  50. ncbi Macula densa sensing and signaling mechanisms of renin release
    Janos Peti-Peterdi
    Departments of Physiology and Biophysics and Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA
    J Am Soc Nephrol 21:1093-6. 2010
    ..Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release...
  51. ncbi Augmented and accelerated nephrogenesis in TGF-beta2 heterozygous mutant mice
    Sunder Sims-Lucas
    Department of Anatomy and Developmental Biology, Monash University, Melbourne 3800, Australia
    Pediatr Res 63:607-12. 2008
    ..we demonstrated that kidneys from TGF-beta2 heterozygous (TGF-beta2(+/-)) mice have approximately 60% more nephrons than wild-type mice at postnatal day 30...
  52. pmc Cell and molecular biology of kidney development
    Kimberly J Reidy
    Department of Pediatrics Division of Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Ave, Bronx, NY 10467, USA
    Semin Nephrol 29:321-37. 2009
    ....
  53. ncbi The kidney from prenatal to adult life: perinatal programming and reduction of number of nephrons during development
    Melania Puddu
    Department of Pediatrics and Clinical Medicine, NICU, University of Cagliari, Cagliari, Italy
    Am J Nephrol 30:162-70. 2009
    ..of genetic factors, several environmental conditions may also contribute towards reducing the number of nephrons in the fetus and infant, subsequently constituting a health burden in later life...
  54. pmc Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring
    Reetu R Singh
    Department of Anatomy and Cell Biology, Monash University, Clayton, 3800, Australia
    J Physiol 579:503-13. 2007
    ..This may have important implications for women experiencing significant stress during pregnancy...
  55. ncbi Control of calbindin-D28K expression in developing mouse kidney
    J Davies
    CRC Epithelial Morphogenesis Group, School of Biological Sciences, Victoria University of Manchester, United Kingdom
    Dev Dyn 199:45-51. 1994
    ..In developing nephrons, its expression is restricted to the most distal end of the growing tubule, commences during differentiation of ..
  56. ncbi Mesenchymal to epithelial conversion in rat metanephros is induced by LIF
    J Barasch
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 99:377-86. 1999
    ..that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then form nephrons. Purification and sequencing of one such factor identified it as leukemia inhibitory factor (LIF)...
  57. pmc SIX2 and BMP4 mutations associate with anomalous kidney development
    Stefanie Weber
    Pediatric Nephrology, University Children s Hospital Heidelberg, Germany
    J Am Soc Nephrol 19:891-903. 2008
    ..Defects in these proteins could affect kidney development at multiple stages, leading to the congenital anomalies observed in patients with RHD...
  58. pmc Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells
    Scott C Boyle
    Departments of Developmental Biology and Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:4245-54. 2011
    ..These functions are carried out by specialized epithelial cells organized into tubules called nephrons. Each of these cell types arise during embryonic development from a mesenchymal stem cell pool through a process ..
  59. pmc Cessation of renal morphogenesis in mice
    Heather A Hartman
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Dev Biol 310:379-87. 2007
    ..These results suggest that the sequence of events leading to disruption of the cycle of branching morphogenesis and nephrogenesis began with the loss of mesenchyme that resulted from its conversion into nephrons.
  60. ncbi Microalbuminuria in adults after prenatal exposure to the Dutch famine
    Rebecca C Painter
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center at the University of Amsterdam, The Netherlands
    J Am Soc Nephrol 16:189-94. 2005
    ..Midgestation is a period of rapid increase in nephron number, which is critical in determining nephron endowment at birth. Fetal undernutrition may lead to lower nephron endowment with consequent MA in adult life...
  61. ncbi Excellent long-term cancer control with elective nephron-sparing surgery for selected renal cell carcinomas measuring more than 4 cm
    Frank Becker
    Department of Urology and Paediatric Urology, Homburg, University of the Saarland, Germany
    Eur Urol 49:1058-63; discussion 1063-4. 2006
    ..However, NSS for tumours > 4 cm is controversial. We present our experiences and long-term oncologic outcome of RCC > 4 cm treated with NSS in a retrospective single-institutional analysis of 69 patients...
  62. ncbi Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm
    Valeria Di Giovanni
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Development 138:2717-27. 2011
    ..Together, these results demonstrate a requirement for Alk3 in distinct progenitor cell populations derived from the intermediate mesoderm...
  63. ncbi Identification and localization of TRPC channels in the rat kidney
    Monu Goel
    Rammelkamp Ctr for Education and Research, Rm R 322, MetroHealth Medical Ctr, 2500 MetroHealth Dr, Cleveland, OH 44109 1998, USA
    Am J Physiol Renal Physiol 290:F1241-52. 2006
    ..These results suggest that TRPC1, -C3, and -C6 may play a functional role in PLC-dependent signaling in specific regions of the nephron...
  64. pmc Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny
    Stephen P Gray
    Department of Anatomy, Monash University, Clayton, Victoria, Australia
    J Am Soc Nephrol 21:1891-902. 2010
    ..Taken together, these data demonstrate that acute prenatal ethanol exposure reduces the number of nephrons, possibly as a result of inhibited ureteric branching morphogenesis, and that these changes affect adult ..
  65. ncbi The renal segmental distribution of claudins changes with development
    Jose Luis Reyes
    Center for Research and Advanced Studies CINVESTAV, Department of Physiology, Biophysics and Neurosciences, Mexico City, Mexico
    Kidney Int 62:476-87. 2002
    ..We studied the differential expression of occludin and several claudins in isolated renal tubules from newborn and adult rabbits...
  66. ncbi Effects of dietary protein restriction on nephron number in the mouse
    Chantal C Hoppe
    Dept of Anatomy and Cell Biology, School of Biomedical Sciences, Monash Univ, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 292:R1768-74. 2007
    ..We conclude that maternal protein restriction reduces nephron endowment in mice. This effect provides a basis for future studies of developmental programming in the mouse...
  67. pmc Podocyte-derived BMP7 is critical for nephron development
    Itsuro Kazama
    Division of Nephrology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 19:2181-91. 2008
    Individuals with congenital renal hypoplasia display a defect in the growth of nephrons during development...
  68. ncbi Claudin-2 is selectively expressed in proximal nephron in mouse kidney
    A H Enck
    Renal Division and Membrane Biology Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Renal Physiol 281:F966-74. 2001
    ..throughout the proximal tubule and in the contiguous early segment of the thin descending limb of long-looped nephrons. The level of expression demonstrated an axial increase from proximal to distal segments...
  69. ncbi Nephron number, hypertension, renal disease, and renal failure
    Wendy E Hoy
    Centre for Chronic Disease, The University of Queensland, Discipline of Medicine, Royal Brisbane and Women s Hospital, Herston QLD 4029, Australia
    J Am Soc Nephrol 16:2557-64. 2005
  70. pmc Atlas of gene expression in the developing kidney at microanatomic resolution
    Eric W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Cell 15:781-91. 2008
    ..In addition, the results provide deeper insight into the genetic regulatory mechanisms of kidney development...
  71. pmc Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age
    Jeffrey S Gilbert
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Physiol 565:137-47. 2005
    ..These data demonstrate the existence of a critical window of fetal susceptibility during early to mid-gestation that alters kidney development and blood pressure regulation in later life...
  72. ncbi Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice
    Luise A Cullen-McEwen
    Department of Anatomy and Cell Biology, Monash University, Victoria, Australia
    Hypertension 41:335-40. 2003
    ....
  73. ncbi Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk
    Patsy Clark
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Am Soc Nephrol 15:299-305. 2004
    ..syndrome (RCS), null mutations of the PAX2 gene cause renal hypoplasia due to a congenital deficit of nephrons; affected individuals may develop renal insufficiency in childhood...
  74. ncbi A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid
    Reyhan El Kares
    Department of Pediatrics, Montreal Children s Hospital Research Institute, McGill University, and Département de Médecine, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Kidney Int 78:96-102. 2010
    ..As maternal vitamin A deficiency is widespread in developing countries and may compromise availability of retinol for fetal RA synthesis, our study suggests that the ALDH1A2 rs7169289(G) variant might be protective for such individuals...
  75. ncbi Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice
    L A Cullen-McEwen
    Department of Anatomy and Cell Biology, Department of Medicine, Monash University, Clayton, Victoria, Australia
    Kidney Int 60:31-6. 2001
    ..Since nephron initiation only occurs at the tips of ureteric branches, the aim of the present study was to determine whether nephron number in GDNF heterozygous mice is reduced...
  76. ncbi Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment
    Kylie Georgas
    NHMRC Principal Research Fellow, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    Dev Biol 332:273-86. 2009
    ..Using Six2-eGFPCre x R26R-lacZ mice, we demonstrate that these cells are derived from the cap mesenchyme and not the ureteric epithelium. Hence, both nephron patterning and patency are evident at the late renal vesicle stage...
  77. ncbi Optimal margin in nephron-sparing surgery for renal cell carcinoma 4 cm or less
    Quan lin Li
    Department of Urology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian 116011, People s Republic of China
    Eur Urol 44:448-51. 2003
    ..This study was designed to investigate the distance between extra-pseudocapsule cancer lesions and primary tumors, and to suggest the optimal margin of normal parenchyma in NSS for RCC 4 cm or less...
  78. ncbi Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    Sebastian Bachmann
    Medical Faculty of the Charite, Department of Anatomy, Franz Volhard Clinic, HELIOS Clinics and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Am J Physiol Renal Physiol 288:F559-67. 2005
    ..Our data raise the hypothesis that THP plays an important regulatory role in the kidney...
  79. ncbi The baboon as a good model for studies of human kidney development
    Lina Gubhaju
    Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria, Australia
    Pediatr Res 58:505-9. 2005
    ..At 175 d gestation and at term, the nephrons seemed to be mature. Both kidney weight (R2= 0.918, p = 0.0002) and kidney volume (R2= 0.837, p = 0...
  80. ncbi Nephron number and blood pressure in rat offspring with maternal high-protein diet
    Monika A Zimanyi
    Department of Anatomy and Cell Biology, P O Box 13C, Monash University, 3800 Victoria, Australia
    Pediatr Nephrol 17:1000-4. 2002
    ..These findings show that a HPD during pregnancy did not lead to an increase in birth weight, kidney weight, or nephron endowment, nor did the HPD affect adult blood pressure...
  81. ncbi Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey
    Carsten Paul Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Gottingen, Germany
    Hypertension 54:1115-22. 2009
    ..Our data support the role of body weight as a predictor of elevated glomerular volume and BP development rather than prenatal dexamethasone exposure...
  82. ncbi Relation of distal nephron changes to proximal tubular damage in uranyl acetate-induced acute renal failure in rats
    Di Fei Sun
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Nephrol 22:405-16. 2002
    ....
  83. ncbi Developmental programming of a reduced nephron endowment: more than just a baby's birth weight
    Karen M Moritz
    School of Biomedical Sciences, Univ of Queensland, 4072, Australia
    Am J Physiol Renal Physiol 296:F1-9. 2009
    ..Recognition of the dissociation between birth weight and nephron endowment is important for future studies aimed at elucidating the role of a reduced nephron endowment in the developmental programming of adult disease...
  84. ncbi Urine-concentrating defects exacerbate with age in male offspring with a low-nephron endowment
    Reetu R Singh
    School of Biomedical Sciences, University of Queensland, St Lucia, 4067 QLD, Australia
    Am J Physiol Renal Physiol 301:F1168-76. 2011
    ..Renal insufficiency due to a low-nephron endowment increases the risk of hypertension and chronic renal disease and may incur greater vulnerability to physiological challenges such as water deprivation as observed in the uni-x animals...
  85. ncbi High nephron endowment protects against salt-induced hypertension
    Kenneth A Walker
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Am J Physiol Renal Physiol 303:F253-8. 2012
    ..This is the first study to examine the physiological characteristics of a model of high nephron number, and the findings are consistent with this phenotype providing protection against chronic, but not acute, hypertensive insults...
  86. pmc Albuminuria indicates the pressure-associated injury of juxtamedullary nephrons and cerebral strain vessels in spontaneously hypertensive stroke-prone rats
    Tasuku Nagasawa
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 35:1024-31. 2012
    ..Nifedipine inhibited stroke events in these animals until they were 14 weeks old. These results indicate that albuminuria is a result of juxtamedullary nephron injury and a marker of pressure-induced injury of the strain vessels...
  87. pmc Advances in early kidney specification, development and patterning
    Gregory R Dressler
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 136:3863-74. 2009
    ..How these developments influence and advance our understanding of kidney development is discussed...
  88. pmc Superficial nephrons in BALB/c and C57BL/6 mice facilitate in vivo multiphoton microscopy of the kidney
    Ina Maria Schießl
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    PLoS ONE 8:e52499. 2013
    ..In summary, due to significantly more superficial glomeruli compared to other commonly used strains, BALB/cAnN and C57BL/6N mice appear to be particularly suitable for the investigation of glomerular function using MPM...
  89. ncbi Ca2+ Imaging as a tool to assess TRP channel function in murine distal nephrons
    Mykola Mamenko
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA
    Methods Mol Biol 998:371-84. 2013
    ..technical aspects of using Ca(2+) imaging to monitor activity of TRP channels in situ, namely, in the freshly isolated distal nephrons, with a special emphasis on the mechanosensitive TRPV4 channel and its role in tubular flow sensing.
  90. ncbi Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney
    K A Brennan
    Centre for Reproduction and Early Life, Institute of Clinical Research, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Reproduction 129:151-9. 2005
    ..This may impact on later kidney development and function...
  91. ncbi High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways
    Yun Wen Chen
    Universite de Montreal, Centre de recherche du Centre Hospitalier de l Universite de Montreal, CRCHUM, Hopital Hotel Dieu, Pavillon Masson, 3850 Saint Urbain St, Montreal, Quebec, Canada H2W 1T7
    Am J Physiol Renal Physiol 300:F147-56. 2011
    ..Our data demonstrate that high glucose-induced nascent nephron apoptosis is mediated, at least in part, via ROS generation and the activation of NF-κB and p53 pathways...
  92. ncbi Development of newly formed nephrons in the goldfish kidney following hexachlorobutadiene-induced nephrotoxicity
    R Reimschuessel
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201
    Toxicol Pathol 18:32-8. 1990
    New nephrons developed in goldfish, Carassius auratus, several weeks following hexachlorobutadiene-induced (HCBD) nephrotoxicity...
  93. pmc Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling
    Megha A Nagle
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:243-51. 2011
    ..Because the HIV antivirals are used in pregnant women, the results may also help in understanding how these drugs are handled by developing organs...
  94. ncbi Adult hypertension and kidney disease: the role of fetal programming
    Kambiz Zandi-Nejad
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 47:502-8. 2006
    ....
  95. ncbi Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
    Melina Narlis
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Am Soc Nephrol 18:1121-9. 2007
    ..Both genes are coexpressed in differentiating nephrons and collecting ducts...
  96. pmc Large-scale identification of genes implicated in kidney glomerulus development and function
    Minoru Takemoto
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    EMBO J 25:1160-74. 2006
    ..We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease...
  97. ncbi Mapping of sex hormone receptors and their modulators along the nephron of male and female mice
    Adrien Grimont
    UPMC Univ Paris 6 CNRS INSERM, Centre de Recherche des Cordeliers, Laboratoire de Génomique, Physiologie et Physiopathologie, Rénales, UMRS, 872 Equipe 3 ERL 7226, 15 rue de l Ecole de Medecine, Paris Cedex, France
    FEBS Lett 583:1644-8. 2009
    ..This first "renal map" of sex steroid receptor expression may serve as a pre-requisite for investigating the role of these hormones on kidney functions...
  98. pmc High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population
    Joshua W Mugford
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 333:312-23. 2009
    ..During its organogenesis, the mammalian metanephric kidney generates thousands of nephrons over a protracted period of fetal life...
  99. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  100. pmc Purinergic inhibition of ENaC produces aldosterone escape
    James D Stockand
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 21:1903-11. 2010
    ..These data suggest that control of ENaC by purinergic signaling is necessary for aldosterone escape...
  101. ncbi Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule
    Pierre Meneton
    Unité 367 de l Institut National de la Santé et de la Recherche Médicale, 75005 Paris, France
    Am J Physiol Renal Physiol 287:F593-601. 2004
    ....

Research Grants62

  1. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..will correlate with either increases (CONT-KD) or decreases (ST-KD) of Na delivery and O2 consumption in distal nephrons. The second specific aim tests the hypothesis that the efficacy of PTRA to restore renal function is determined ..
  2. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..These crystals can be nephrotoxic, evoke an inflammatory response leading to fibrosis, loss of nephrons and possible renal failure...
  3. Mechanism of Gene Repression in the Kidney
    Sanjeevkumar R Patel; Fiscal Year: 2013
    ..of loci that respond to inductive signaling and as such sits near the top of a genetic network that specifies the nephrons, collecting ducts, and ureters...
  4. Genetic Analysis of Etv4/Etv5 Transcription Factors and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..Furthermore, the number of nephrons is extremely variable in "normal" humans, and low nephron number is thought to promote the progression of renal ..
  5. Role of Par1 Polarity Proteins in Podocyte Development and Glomerular Disease
    KIMBERLY JEAN REIDY; Fiscal Year: 2013
    ..Recent work performed under the guidance of her mentors demonstrated that Par1a/b is expressed in developing nephrons and in rodent and human podocytes...
  6. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
    ..In these conditions it is chronic progressive renal fibrosis with associated loss of functioning nephrons that results in irreversible renal injury...
  7. AT1 Receptors in Renal Microvascular Physiology
    LISA HARRISON BERNARD; Fiscal Year: 2009
    ..AA) diameter responses to intrarenally produced ANGII will be measured in blood perfused juxtamedullary nephrons. The results from the proposed studies will identify an alternative mechanism for ANGII production in diabetic ..
  8. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    Thomas L Pallone; Fiscal Year: 2013
    ..See instructions): The vasa recta of the renal medulla trap NaCI and urea deposited to the interstitium by nephrons and distribute blood flow to the outer and inner medulla...
  9. The Role of p120 Catenin in Metanephric Kidney Development
    DENISE K MARCIANO; Fiscal Year: 2012
    ..My preliminary data shows that newborn mice lacking p120ctn in nephrons develop kidney cysts and renal hypoplasia...
  10. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..Indeed, there is now evidence that the number of nephrons endowed before birth in your kidneys can affect whether or not you will present with chronic renal disease later ..
  11. The macro- and micro- anatomy and pathology of the aging kidney
    ANDREW DAVID RULE; Fiscal Year: 2013
    ..biopsy findings (glomeruli per renal cortex unit volume) allows estimation of nephron endowment (total number of nephrons a person is born with)...
  12. Generation of novel models of kidney defects using the zebrafish
    REBECCA ANN WINGERT; Fiscal Year: 2013
    ..Previous genetic screens isolated zebrafish kidney mutants in which nephrons-the functional units of the kidney-evince cyst formation...
  13. Mechanism of Compensatory Renal Hypertrophy
    Jian Kang Chen; Fiscal Year: 2013
    ..virtually all kidney diseases that cause nephron damage and consequently a reduction in the number of functioning nephrons. CRH may actually be a maladaptive response and has been increasingly implicated in fostering further nephron ..
  14. MECHANISM OF ACTION OF COUP-TRANSCRIPTION FACTORS
    Ming Jer Tsai; Fiscal Year: 2013
    ..When COUP-TFII is knocked out at a later stage, very few nephrons are apparent and there is no detectable distal tubule, suggesting that COUP-TFII is critical for the formation ..
  15. BMP and FGF Signaling in kidney progenitor cells
    Jordan A Kreidberg; Fiscal Year: 2013
    ..to replace kidney tissue in children and adults with irreversible kidney damage, resulting from the loss of nephrons. At present, irreversible kidney damage leads to dialysis and transplantation, situations that carry with them ..
  16. THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
    Alan M Weinstein; Fiscal Year: 2013
    ..period, the first task is to complete the library of renal segmental models, and fashion short- and long-looped nephrons, solved against interstitial composition...
  17. Interactions between the stroma and progenitor cells during kidney development
    THOMAS JOSEPH CARROLL; Fiscal Year: 2013
    ..a balance is struck between amplification and differentiation of these progenitors to assure the proper number of nephrons form...
  18. Identification of Kidney Regeneration Mechanisms Using the Zebrafish
    REBECCA ANN WINGERT; Fiscal Year: 2011
    ..Interestingly, human nephrons have the capacity to replace damaged nephron cells through regeneration...
  19. Genetic Analysis of Pathways Controlling Nephron Segmentation Using the Zebrafish
    REBECCA ANN WINGERT; Fiscal Year: 2013
    ..of mammalian kidney development, there is a paucity of knowledge regarding how renal progenitors form mature nephrons-the fundamental units of the kidney that are made up of a series of discrete functional segments...
  20. GDNF/Ret Regulation of Ureteric Bud Morphogenesis
    ADAM I PACKARD; Fiscal Year: 2012
    ..a spectrum of kidney malformations, ranging from a complete failure to form kidneys to smaller kidneys with fewer nephrons. In light of the impact that defective kidney development has on a person's health, a deeper understanding ..
  21. Aldosterone-independent regulation of ENaC by systemic salt
    Oleh Pochynyuk; Fiscal Year: 2013
    ..balance studies and will combine 1) patch clamp measurements of ENaC activity in the split-open murine distal nephrons with ENaC expression levels probed by western blotting/RPPA and immunohistochemistry, and 2) balance studies to ..
  22. Oxalate Reduction by Oral Administration of Oxalate Degrading Enzymes
    Qingshan Li; Fiscal Year: 2010
    ..the kidneys can evoke an inflammatory response and induce tubulointerstitial damage leading to fibrosis, loss of nephrons, and eventually to chronic and end-stage renal failure...
  23. Kidney Progenitor Cells in Disease
    STUART JAMES SHANKLAND; Fiscal Year: 2012
    ..Although the adult mammalian kidney lacks nephron progenitors that could regenerate entire nephrons, nevertheless it has remarkable capacity to regenerate...
  24. MicroRNAs in kidney progenitor cells.
    Jacqueline Ho; Fiscal Year: 2011
    ..of the molecular and cellular processes that regulate nephron progenitors in establishing the full complement of nephrons during kidney development...
  25. Pathophysiology of Early Chronic Kidney Disease: Response to Ischemia-Reperfusion
    Prabhleen Singh; Fiscal Year: 2013
    ..In chronic kidney disease (CKD), adaptations in remaining nephrons help maintain the primary functions of the kidney i.e. filtration and salt balance in the earlier stages...
  26. Genetic Regulation of Nephron Progenitor Cells in the Mammalian Kidney
    Akio Kobayashi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Reduced endowment of the nephrons, the basic functional units of the kidney, is associated with future development of hypertension and even chronic kidney disease (CKD), ultimately leading to end ..
  27. RENIN-ANGIOTENSIN AND GROWTH IN URETERAL OBSTRUCTION
    ROBERT CHEVALIER; Fiscal Year: 1991
    ..the mechanisms of renal injury due to urinary tract obstruction and of compensatory adaptation by unobstructed nephrons remain poorly understood...
  28. MRI Techniques to Measure Whole-Kidney Nephron
    Kevin M Bennett; Fiscal Year: 2013
    ..Deficits in nephrons and glomeruli have been correlated with renal diseases such as diabetes, obesity, and hypertension...
  29. CYSTIC DILATATION OF NEPHRONS IN TRANSGENIC INV MICE
    Carrie Phillips; Fiscal Year: 2005
    ..Second, we will identify crucial binding partners of inversin in these cultured systems by blocking in vitro translation and assaying for changes in PKD-associated proteins. ..
  30. ISOPROSTANES IN LIVER DISEASE-INDUCED RENAL DYSFUNCTION
    Luis Juncos; Fiscal Year: 2004
    ..of intrarenal RBF; that is there is cortical vasoconstriction with shunting of RBF towards the juxtamedullary nephrons, which may contribute to enhanced sodium and water retention...
  31. Kidney vascularization: semaphorin-mediated mechanisms.
    Alda Tufro; Fiscal Year: 2006
    ..VEGF is a chemoattractant for endothelial cells and directs the migration of endothelial cells towards developing nephrons. Other guidance cues are necessarily involved to modulate vascular growth...
  32. MECHANISMS OF PROTEIN ACCUMULATION IN RENAL HYPERTROPHY
    Harold Franch; Fiscal Year: 2002
    ..The kidney responds to loss of nephrons or metabolic derangements by increasing the size of existing glomeruli and tubules rather than by duplicating ..
  33. HUMORAL MECHANISMS OF INJURY IN SURVIVING NEPHRONS
    Karl Nath; Fiscal Year: 1992
    ..the reduction of renal mass, adaptive alterations in both glomerular and tubular functions occur in surviving nephrons. There is increasing recognition that such adaptation exerts injurious effects, and provide pathways for ..
  34. CYSTIC DILATATION OF NEPHRONS IN TRANSGENIC INV MICE
    Carrie Phillips; Fiscal Year: 2005
    ..We believe the inv/inv model offers a new an exciting opportunity to extend the understanding of the genetic mechanisms of nephrogenesis and the abnormalities in this process which lead to PKD. ..
  35. PROTEINASES IN KIDNEY EPITHELIAL BRANCHING MORPHOGENESIS
    Robert Stuart; Fiscal Year: 2000
    ..Approximately 1 million nephrons are induced to form as the result of as many as 20 iterations of dichotomous branching of this structure...
  36. FUNCTIONAL & HORMONAL ADAPTATIONS OF REMNANT NEPHRONS
    JUAN PELAYO; Fiscal Year: 1993
    ..that the chronic functional and structural compensatory adaptations of the normal or minimally diseased remnant nephrons are central to the progressive nature of renal disease...
  37. MOLECULAR GENETICS OF C ELEGANS RENAL TUBULES
    Matthew Buechner; Fiscal Year: 2002
    ..is one of the most common human genetic conditions, and causes the slow swelling of cysts within a subset of nephrons over the course of years, which eventually results in loss of nephritic function and end- stage renal disease...
  38. ZINC FINGERS IN KIDNEY DEVELOPMENT
    ERIC NEILSON; Fiscal Year: 1999
    ..likely that steps towards terminal differentiation involve changes in protein expression in and around developing nephrons, and such changes are probably controlled by as yet undescribed genes...
  39. CELL INTERACTIONS IN DEVELOPMENT OF THE MAMMALIAN KIDNEY
    Andrew McMahon; Fiscal Year: 2007
    ..Simply put, how do nephrons form? A variety of experiments over the last fifty years have highlighted the importance of cell-cell ..
  40. MATHEMATICAL MODELS OF RENAL DYNAMICS
    HAROLD LAYTON; Fiscal Year: 2009
    ..differential equations, will be used to investigate the following hypotheses: (I) vascular coupling between nephrons increases the propensity for oscillatory dynamics and serves as a regulatory mechanism for increasing NaCI ..
  41. MECHANISM OF RENAL ACID-BASE HOMEOSTASIS
    Thomas DuBose; Fiscal Year: 1980
    ..cortical and papillary nephron segments), and by in vivo perfusion of superficial proximal and distal nephrons. Three specific experiments will be performed: (1) determination of the magnitude and direction of the directly ..
  42. TRANSCRIPTION FACTORS AND RENAL DEVELOPMENT
    Peter Igarashi; Fiscal Year: 2002
    ..Cux-1 is highly expressed during early stages of nephrogenesis then is down-regulated as nephrons mature. Expression of Cux-1 remains persistently elevated in polycystic kidneys from homozygous cpk mice...
  43. Decoupling of Principal Renal Autoregulatory Mechanisms
    Ki Chon; Fiscal Year: 2005
    ..IN addition to these intra-nephron interactions between TOP and the myogenic mechanism, nephrons derived from the same radial cortical artery interact through the arteriolar wall...
  44. REGULATION OF GLOMERULAR AND PROXIMAL NEPHRON FUNCTION
    Leon Moore; Fiscal Year: 1992
    ..directly in preglomerular vessels and the macula densa region of in vitro, blood-perfused, juxtamedullary nephrons and cultured mesangial cells from rat kidney. The specific aims are: 1...
  45. MATURATION OF THE FETAL KIDNEY
    Jean Robillard; Fiscal Year: 1990
    ..4. The relation between the rate of filtraton in the cortical nephrons versus the juxtamedullary nephrons during gestation and immediately after birth utilizing a modification of the ..
  46. THE ETIOLOGY OF GENETIC HYPERTENSION
    H Reineck; Fiscal Year: 1980
    ..In each of these conditions delivery of sodium and chloride to the bend of Henle's loop of juxtamedullary nephrons and the late distal tubule of superficial nephrons and the base and tip of the papillary collecting duct will be ..
  47. MICROPUNCTURE STUDY OF URATE TRANSPORT IN RAT KIDNEY
    Ruth Abramson; Fiscal Year: 1980
    ..at defining more precisely the mechanism(s) of the unidirectional fluxes of urate in the proximal tubule of rat nephrons. To accomplish this goal, urate transport will be assessed in luminal and contraluminal membrane vesicles from ..
  48. Modeling renal development
    Deborah Hyink; Fiscal Year: 2005
    ..Disruption of the normal pattern of epithelial branching can result in a reduction in the number of nephrons formed. This reduction in nephron number has been correlated with hypertension and chronic renal failure...
  49. MULTIPOTENT PROGENITOR CELLS IN THE KIDNEY
    Deborah Hyink; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) The normal human kidney has 300,000 to one million nephrons per kidney. A reduced number of nephrons is correlated with hypertension and chronic renal failure...
  50. Molecular Regulation of Nephron Formation
    MICHAEL VALERIUS; Fiscal Year: 2003
    The human kidney is made up about 1 million nephrons, the working unit of the kidney. Each nephron is a very complex structure with highly specialized segments responsible for specific physiological functions...
  51. THE FUNCTIONAL ROLE OF SIX2 IN KIDNEY TUBULOGENESIS
    Guillermo Oliver; Fiscal Year: 2005
    ..then undergoes proliferation and differentiation to give rise to the different segments of the secretory nephrons, the functional unit of the adult kidney...
  52. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  53. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..is marked activation of the intrarenal renin-angiotensin system, and heterogeneity in filtration among individual nephrons. The long-term renal consequences of chronic unilateral ureteral obstruction (UUO) are dependent on the balance ..
  54. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  55. Non-linear regulation of the renal circulation
    DONALD MARSH; Fiscal Year: 2007
    ..The revised proposal answers questions raised in the first review, and presents new results from simulations of coupled cortical and medullary nephrons.
  56. GLOMERULAR CAPILLARY WALL--NORMAL AND PATHOLOGIC
    Yashpal Kanwar; Fiscal Year: 2008
    ..Null alleles will be interbred to generate Null -/- mutant as a conventional KO mice with ablation of the TIN-ag gene. ..
  57. Mechanisms of Sexual Dimorphism in Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..Renal renin-angiotensin system components will be measured in the neonatal period, and arterial pressure, renal function, and glomerular number and volume will be measured in juvenile and adult animals. ..
  58. ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEY
    Gerhard Giebisch; Fiscal Year: 2003
    ..Patch-clamp and whole-cell current measurements will be carried out in native tubules and in an oocyte expression system, and tubule perfusion studies in ROMK knock-out mice. ..
  59. Pathobiology of HMG-CoA reductase inhibitors in diabetes
    Yashpal Kanwar; Fiscal Year: 2006
    ....
  60. Renal and Hormonal Mechanisms of Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..corticoids suppress the intrarenal renin-angiotensin system in the fetus/newborn, leading to a reduced number of nephrons, reduced renal function, and hypertension...
  61. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..Thus, understanding the epigenetic regulation of kidney development may open new avenues to the treatment or prevention of kidney and urinary tract malformations and kidney failure. ..
  62. AVIAN VASCULAR FUNCTION
    Hiroko Nishimura; Fiscal Year: 2007
    ..The proposed projects will be supported by five distinguished consultants. [unreadable] [unreadable]..