kidney glomerulus

Summary

Summary: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.

Top Publications

  1. ncbi Cell biology of the glomerular podocyte
    Hermann Pavenstadt
    Division of Nephrology, Department of Medicine, University Hospital Freiburg, Freiburg, Germany
    Physiol Rev 83:253-307. 2003
  2. pmc M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy
    Laurence H Beck
    Boston University School of Medicine, Boston, MA, USA
    N Engl J Med 361:11-21. 2009
  3. ncbi The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
    Daniel C Cattran
    University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada
    Kidney Int 76:534-45. 2009
  4. pmc A new method for large scale isolation of kidney glomeruli from mice
    Minoru Takemoto
    Department of Medical Biochemistry, Goteborg University, Sweden
    Am J Pathol 161:799-805. 2002
  5. pmc VEGF inhibition and renal thrombotic microangiopathy
    Vera Eremina
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1129-36. 2008
  6. ncbi Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    P Mundel
    Department of Anatomy and Cell Biology, University of Heidelberg, Germany
    Exp Cell Res 236:248-58. 1997
  7. ncbi From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy
    Gunter Wolf
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 4218, USA
    Diabetes 54:1626-34. 2005
  8. pmc Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    Vera Eremina
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 111:707-16. 2003
  9. ncbi Role of the VEGF--a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier
    Vera Eremina
    The Samuel Lunenfeld Research Institute, University of Toronto, Toronto, ON, Canada
    Nephron Physiol 106:p32-7. 2007
  10. pmc Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
    Björn Hartleben
    Renal Division, University Hospital Freiburg, Germany
    J Clin Invest 120:1084-96. 2010

Research Grants

Detail Information

Publications304 found, 100 shown here

  1. ncbi Cell biology of the glomerular podocyte
    Hermann Pavenstadt
    Division of Nephrology, Department of Medicine, University Hospital Freiburg, Freiburg, Germany
    Physiol Rev 83:253-307. 2003
    ..This review integrates our recent physiological and molecular understanding of the role of podocytes during the maintenance and failure of the glomerular filtration barrier...
  2. pmc M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy
    Laurence H Beck
    Boston University School of Medicine, Boston, MA, USA
    N Engl J Med 361:11-21. 2009
    ..Idiopathic membranous nephropathy, a common form of the nephrotic syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis has been elusive because the target antigen is unknown...
  3. ncbi The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
    Daniel C Cattran
    University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada
    Kidney Int 76:534-45. 2009
    ..The value of crescents was not addressed due to their low prevalence in the enrolled cohort...
  4. pmc A new method for large scale isolation of kidney glomeruli from mice
    Minoru Takemoto
    Department of Medical Biochemistry, Goteborg University, Sweden
    Am J Pathol 161:799-805. 2002
    ..This method makes feasible transcript profiling and proteomic analysis of the developing, healthy and diseased mouse glomerulus...
  5. pmc VEGF inhibition and renal thrombotic microangiopathy
    Vera Eremina
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1129-36. 2008
    ..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy...
  6. ncbi Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    P Mundel
    Department of Anatomy and Cell Biology, University of Heidelberg, Germany
    Exp Cell Res 236:248-58. 1997
    ..Therefore, the determinative steps of podocyte differentiation and process formation are studied for the first time using an inducible in vitro model...
  7. ncbi From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy
    Gunter Wolf
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 4218, USA
    Diabetes 54:1626-34. 2005
    ..The mainstays of therapy, glycemic control and inhibition of ANG II, are key measures to prevent early podocyte injury and the subsequent development of diabetic nephropathy...
  8. pmc Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    Vera Eremina
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 111:707-16. 2003
    ..Our data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGF-A in renal disease...
  9. ncbi Role of the VEGF--a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier
    Vera Eremina
    The Samuel Lunenfeld Research Institute, University of Toronto, Toronto, ON, Canada
    Nephron Physiol 106:p32-7. 2007
    ....
  10. pmc Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
    Björn Hartleben
    Renal Division, University Hospital Freiburg, Germany
    J Clin Invest 120:1084-96. 2010
    ....
  11. ncbi Nephron number in patients with primary hypertension
    Gunhild Keller
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    N Engl J Med 348:101-8. 2003
    ..A diminished number of nephrons has been proposed as one of the factors contributing to the development of primary hypertension...
  12. ncbi Properties of the glomerular barrier and mechanisms of proteinuria
    Borje Haraldsson
    Department of Molecular and Clinical Medicine Nephrology, Institute of Medicine, Goteborg University, Sweden
    Physiol Rev 88:451-87. 2008
    ..The cellular components are the key players in restricting solute transport, while the GBM is responsible for most of the resistance to water flow across the glomerular barrier...
  13. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
    ....
  14. pmc MYO1E mutations and childhood familial focal segmental glomerulosclerosis
    Caterina Mele
    Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò Ranica, Bergamo, Italy
    N Engl J Med 365:295-306. 2011
    ..However, the molecular cause in over half the cases of primary focal segmental glomerulosclerosis is unknown, and effective treatments have been elusive...
  15. pmc Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease
    Akihiro Fukuda
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5676, USA
    Kidney Int 81:40-55. 2012
    ..These events can be monitored noninvasively in real-time through urine mRNA assays...
  16. ncbi Glomerular hyperfiltration: definitions, mechanisms and clinical implications
    Imed Helal
    Division of Renal Diseases and Hypertension, University of Colorado Denver, 12700 East 19th Avenue, Campus Box C281, Aurora, CO 80045, USA
    Nat Rev Nephrol 8:293-300. 2012
    ..A better understanding of the mechanisms involved in glomerular hyperfiltration could enable the development of new strategies to prevent progression of kidney disease...
  17. ncbi Podocyte biology and response to injury
    Peter Mundel
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 13:3005-15. 2002
  18. ncbi Glomerular number and size in autopsy kidneys: the relationship to birth weight
    Michael Hughson
    University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Kidney Int 63:2113-22. 2003
    ..This study investigates the relationships between age, race, gender, total glomerular number (Nglom), mean glomerular volume (Vglom), body surface area (BSA), and birth weight...
  19. pmc Recruitment of podocytes from glomerular parietal epithelial cells
    Daniel Appel
    Division of Nephrology and Immunology, Rheinisch Westfälische Technische Hochschule University of Aachen, Aachen, Germany
    J Am Soc Nephrol 20:333-43. 2009
    ..In conclusion, we demonstrate for the first time recruitment of podocytes from PECs in juvenile mice. Unraveling the mechanisms of PEC recruitment onto the glomerular tuft may lead to novel therapeutic approaches to renal injury...
  20. ncbi Adriamycin nephropathy: a model of focal segmental glomerulosclerosis
    Vincent W S Lee
    Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, New South Wales, Australia
    Nephrology (Carlton) 16:30-8. 2011
    ..This review will outline the pharmacological behaviour of Adriamycin, and describe in detail the model of AN, including its key structural characteristics, genetic susceptibility and pathogenesis...
  21. ncbi Pathologic classification of diabetic nephropathy
    Thijs W Cohen Tervaert
    Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 21:556-63. 2010
    ..A good interobserver reproducibility for the four classes of DN was shown (intraclass correlation coefficient = 0.84) in a test of this classification...
  22. pmc Apoptosis in podocytes induced by TGF-beta and Smad7
    M Schiffer
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:807-16. 2001
    ..Our results suggest a novel functional role for Smad7 as amplifier of TGF-beta-induced apoptosis in podocytes and a new pathomechanism for podocyte depletion in progressive glomerulosclerosis...
  23. ncbi Alport's syndrome, Goodpasture's syndrome, and type IV collagen
    Billy G Hudson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2358, USA
    N Engl J Med 348:2543-56. 2003
  24. ncbi Glomerular epithelial stem cells: the good, the bad, and the ugly
    Laura Lasagni
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    J Am Soc Nephrol 21:1612-9. 2010
    ..Better understanding of the mechanisms that regulate growth and differentiation of glomerular epithelial stem cells may provide new clues for prevention and treatment of glomerulosclerosis...
  25. pmc TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
    Jochen Reiser
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Genet 37:739-44. 2005
    ..Two of the TRPC6 mutants had increased current amplitudes. These data show that TRPC6 channel activity at the slit diaphragm is essential for proper regulation of podocyte structure and function...
  26. pmc Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury
    Jacqueline Ho
    Department of Medicine, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 19:2069-75. 2008
    ..These results suggest that miRNA function is dispensable for the initial development of glomeruli but is critical to maintain the glomerular filtration barrier...
  27. ncbi Insulin signaling to the glomerular podocyte is critical for normal kidney function
    Gavin I Welsh
    Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK
    Cell Metab 12:329-40. 2010
    ..Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function...
  28. ncbi Diabetic eNOS knockout mice develop distinct macro- and microvascular complications
    Sumathy Mohan
    Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Lab Invest 88:515-28. 2008
    ..The DKO model may suggest novel therapeutic strategies to prevent both vascular and renal complications of diabetes...
  29. ncbi Glomeruli and blood pressure. Less of one, more the other?
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115
    Am J Hypertens 1:335-47. 1988
    ..This may also account for the susceptibility of subsets of Type I and Type II diabetics to develop overt glomerulopathy...
  30. pmc Increased tubular proliferation as an adaptive response to glomerular albuminuria
    Jian Kan Guo
    Section of Nephrology and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Soc Nephrol 23:429-37. 2012
    ..These data suggest that glomerular proteinuria in the absence of severe structural glomerular injury activates tubular proliferation, potentially as an adaptive response to minimize the loss of filtered proteins...
  31. pmc Pathology after eculizumab in dense deposit disease and C3 GN
    Leal C Herlitz
    Division of Renal Pathology, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA
    J Am Soc Nephrol 23:1229-37. 2012
    ..Staining of the γ heavy chain was restricted to the IgG2 and IgG4 subclasses, suggesting the binding of monoclonal eculizumab to C5 in renal tissues. The long-term effects of this apparent drug-tissue interaction are unknown...
  32. pmc Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis
    Guillaume Bollée
    Unité Mixte de Recherche UMR 970, Paris Cardiovascular Research Centre, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Nat Med 17:1242-50. 2011
    ..This suggests that targeting the HB-EGF-EGFR pathway could also be beneficial in treatment of human RPGN...
  33. pmc Early glomerular filtration defect and severe renal disease in podocin-deficient mice
    Séverine Roselli
    Inserm U574, Hopital Necker Enfants Malades, Universite Rene Descartes, Tour Lavoisier 6ème étage, 75743 Paris, France
    Mol Cell Biol 24:550-60. 2004
    ....
  34. pmc Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture
    Ariela Benigni
    Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Bergamo, Italy
    Am J Pathol 179:628-38. 2011
    ..ACEi, by moderating progenitor cell activation, restores glomerular architecture and prevents renal disease progression...
  35. ncbi Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy
    Fuad N Ziyadeh
    Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Curr Diabetes Rev 4:39-45. 2008
    ....
  36. ncbi The role of podocytes in glomerular pathobiology
    Katsuhiko Asanuma
    Division of Nephrology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Exp Nephrol 7:255-9. 2003
    ..Such studies will potentially translate into more refined treatment and the prevention of proteinuria and progressive glomerular disease...
  37. ncbi Glomerular sieving coefficient of serum albumin in the rat: a two-photon microscopy study
    George A Tanner
    Department of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive, MS 332, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 296:F1258-65. 2009
    ..In conclusion, the albumin concentration in the glomerular filtrate of the normal rat, determined by two-photon microscopy, is exceedingly low (5-10 mg/dl)...
  38. ncbi Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis
    Marcus J Moeller
    Division of Nephrology, Department of Internal Medicine, University of Michigan, and Department of Veterans Affairs, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 15:61-7. 2004
    ..Podocyte-specific antigens, including WT-1, synaptopodin, nephrin, and podocin, were not expressed by any cells in glomerular crescents, suggesting that podocytes underwent profound phenotypic changes in this nephritis model...
  39. pmc Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes
    Albrecht G Kramer-Zucker
    Renal Unit, Massachusetts General Hospital 149 8000, 149 13th Street, Charlestown, MA 02129, USA
    Dev Biol 285:316-29. 2005
    Podocytes are specialized cells of the kidney that form the blood filtration barrier in the kidney glomerulus. The barrier function of podocytes depends upon the development of specialized cell-cell adhesion complexes called slit-..
  40. ncbi Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat
    Y H Kim
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Kidney Int 60:957-68. 2001
    ..It raises important questions related to the mechanisms of podocyte loss, strategies for prevention of podocyte depletion, and the prevention of progression of glomerular diseases...
  41. pmc From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy
    Ying Qian
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0680, USA
    Diabetes 57:1439-45. 2008
  42. ncbi The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states
    L M Russo
    Program in Membrane Biology, Renal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 71:504-13. 2007
    ..Thus, restoration of the defective endocytotic and processing function of PT epithelial cells might represent an effective strategy to limit urinary albumin loss, at least in some types of nephrotic syndrome...
  43. ncbi Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man
    B Hohenstein
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Erlangen, Germany
    Kidney Int 69:1654-61. 2006
    ..Diabetic nephropathy is associated with glomerular capillary rarefaction. Despite overall increased glomerular VEGF, the decreased receptor-bound VEGF on the endothelium may be an indicator of an insufficient capillary repair reaction...
  44. ncbi Proteinuria in diabetic kidney disease: a mechanistic viewpoint
    J A Jefferson
    Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Kidney Int 74:22-36. 2008
    ..This review describes the pathophysiological mechanisms at a cellular level which explain why patients with DKD develop proteinuria...
  45. pmc Slit diaphragms contain tight junction proteins
    Hirotaka Fukasawa
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    J Am Soc Nephrol 20:1491-503. 2009
    ..The contribution of these proteins to the assembly of slit diaphragms and potential signaling cascades requires further investigation...
  46. ncbi Membranoproliferative glomerulonephritis type II (dense deposit disease): an update
    Gerald B Appel
    Columbia University, Department of Nephrology, New York, New York, USA
    J Am Soc Nephrol 16:1392-403. 2005
    ..The development of molecular diagnostic tools and new therapies directed at controlling the AP of the complement cascade either locally in the kidney or at the systemic level may lead to effective treatments for MPGN II...
  47. pmc Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Paul O Gorman Lifeline Centre, Southmead Hospital, Bristol, BS10 5NB, United Kingdom
    Am J Physiol Renal Physiol 296:F947-56. 2009
    ....
  48. ncbi Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events
    Y Wang
    Department of Renal Medicine, University of Sydney at Westmead Hospital, Westmead, Australia
    Kidney Int 58:1797-804. 2000
    ..Herein, we describe a stable and reproducible murine model of chronic proteinuria induced by ADR...
  49. ncbi Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies
    Aude Servais
    Department of Nephrology, Hôpital Necker Enfants Malades AP HP, Paris, France
    Kidney Int 82:454-64. 2012
    ..The localization of the C3 deposits may be under the influence of MCP expression...
  50. pmc Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 114:643-51. 2004
    ..These data suggest that Nef-induced activation of Stat3 and Ras-MAPK1,2 via Src-dependent pathways is responsible for podocyte proliferation and dedifferentiation, a characteristic finding in collapsing FSGS of HIVAN...
  51. ncbi Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
    J A Kreidberg
    Division of Nephrology, Children s Hospital, Boston, MA 02115, USA
    Development 122:3537-47. 1996
    ..Branching of the bronchi in lungs of mutant mice was also decreased and the large bronchi extended to the periphery. These results indicate a role for integrin receptors in basement membrane organization and branching morphogenesis...
  52. ncbi Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury
    Taiji Matsusaka
    Department of Pediatrics, Vanderbilt University School of Medicine, 1161 21st Avenue South, MCN C4204, Nashville, TN 37232 2584, USA
    J Am Soc Nephrol 16:1013-23. 2005
    ..Thus, the study has established a mouse model of acquired progressive glomerular sclerosis in which onset and severity can be preprogrammed by experimental maneuvers...
  53. ncbi Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria
    Donghai Yu
    Department of Medicine, Division of Nephrology and Clinical Immunology, University of Aachen, Germany
    J Am Soc Nephrol 16:1733-41. 2005
    ..The data suggest that podocyturia may become a more sensitive means to assess the activity of glomerular damage than proteinuria...
  54. pmc Nck proteins maintain the adult glomerular filtration barrier
    Nina Jones
    Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, New Science Complex, Guelph, Ontario, Canada
    J Am Soc Nephrol 20:1533-43. 2009
    ..These data suggest that Nck is required to maintain adult podocytes and that phosphotyrosine-based interactions with nephrin may occur in foot processes of resting, mature podocytes...
  55. ncbi Heparan sulfate of perlecan is involved in glomerular filtration
    Hiroyuki Morita
    Division of Nephrology, Department of Medicine, Showa University, Fujigaoka Hospital, Medicine, 1 30 Fujigaoka, Aoba ku, Yokohama, Kanagawa, 227 8501, Japan
    J Am Soc Nephrol 16:1703-10. 2005
    ..These findings suggest that heparan sulfate chains of perlecan play an important role in glomerular filtration, especially of a large amount of protein...
  56. ncbi Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm
    Tobias B Huber
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    Nephron Exp Nephrol 106:e27-31. 2007
    ..This review will summarize the most recent findings on protein-lipid supercomplexes at the slit diaphragm and discuss a potential novel function of the slit diaphragm as a mechanosensor...
  57. ncbi Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier
    Borje Haraldsson
    Department of Nephrology, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    News Physiol Sci 19:7-10. 2004
    ..In particular, we will discuss the role of the endothelium, which seems to be a neglected part of the glomerular membrane...
  58. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Conversely, maintaining high APC levels during long-term diabetes protects against diabetic nephropathy...
  59. pmc Cell biology and pathology of podocytes
    Anna Greka
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Annu Rev Physiol 74:299-323. 2012
    As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a unique geographical position: It is exposed to chemical signals from the urinary space (Bowman's capsule), it receives and transmits chemical ..
  60. pmc Anti-C1q autoantibodies in murine lupus nephritis
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 135:41-8. 2004
    ..In conclusion, anti-C1q antibodies are already present in serum and immune deposits of the kidney early in life and therefore can play a role in nephritis during experimental SLE-like disease in mice...
  61. ncbi Genetic inactivation of the laminin alpha5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse
    Cécile Rahuel
    Institut National de la Sante et de la Recherche Medicale, Unité 665, Institut National de la Transfusion Sanguine, Paris, France
    Am J Physiol Renal Physiol 294:F393-406. 2008
    ....
  62. ncbi Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 16:2953-66. 2005
    ..Hypertrophy above a certain threshold was associated with podocyte stress and then failure, culminating in reduced podocyte numbers in sclerotic glomeruli. This process could be prevented by calorie restriction...
  63. ncbi Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria
    Anne Tiina Lahdenkari
    Hospital for Children and Adolescents, University of Helsinki, 00290, Finland
    J Am Soc Nephrol 15:2611-8. 2004
    ....
  64. ncbi Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium
    Sigridur A Asgeirsdottir
    Medical Biology Section, Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Mol Pharmacol 72:121-31. 2007
    ..Immunoliposomal drug delivery to glomerular endothelium presents a powerful new strategy for treatment of glomerulonephritis to sustain efficacy and prevent side effects of potent anti-inflammatory drugs...
  65. ncbi Pathways to nephron loss starting from glomerular diseases-insights from animal models
    Wilhelm Kriz
    Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
    Kidney Int 67:404-19. 2005
    ..The only option for extracapillary injuries with tuft adhesion is repair by formation of a segmental adherent scar (i.e., segmental glomerulosclerosis)...
  66. ncbi Soluble urokinase receptor and focal segmental glomerulosclerosis
    Jochen Reiser
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Curr Opin Nephrol Hypertens 21:428-32. 2012
    ..We discuss recent work on the pathogenetic mechanism of focal segmental glomerulosclerosis (FSGS) and its relationship to soluble urokinase receptor (suPAR)...
  67. ncbi A controlled, prospective study of the effects of atorvastatin on proteinuria and progression of kidney disease
    Stefano Bianchi
    Unita Operativa Nefrologia, Spedali Riuniti di Livorno, Livorno, Italy
    Am J Kidney Dis 41:565-70. 2003
    ..Experimental evidence suggests that lipid abnormalities may contribute to the progression of kidney disease. However, studies in humans on the subject are scarce...
  68. ncbi How does the kidney filter plasma?
    Karl Tryggvason
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Physiology (Bethesda) 20:96-101. 2005
    ....
  69. pmc Inducible podocyte injury and proteinuria in transgenic zebrafish
    Weibin Zhou
    University of Michigan Medical School, 8240 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5646, USA
    J Am Soc Nephrol 23:1039-47. 2012
    ..These data support the use of these transgenic zebrafish as a model system for studies of glomerular pathogenesis and podocyte regeneration...
  70. ncbi Tubular changes in early diabetic nephropathy
    M C Thomas
    Danielle Alberti Memorial Centre for Diabetes Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Adv Chronic Kidney Dis 12:177-86. 2005
    ..From this "holonephric" point of view, an understanding of the changes in the diabetic tubule forms an important component to the understanding of kidney disease in diabetes...
  71. ncbi Mechanisms of everolimus-induced glomerulosclerosis after glomerular injury in the rat
    C Daniel
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Am J Transplant 5:2849-61. 2005
    ..These experimental results suggest special caution regarding the use of everolimus in all situations of severe glomerular cell injury requiring extensive capillary repair, where at least adaption to a low dose needs to be considered...
  72. ncbi Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy
    Yoshihiko Yamamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Diabetes 53:1831-40. 2004
    ..Taken together, these results demonstrate the potential use of antiangiogenic tumstatin peptide as a novel therapeutic agent in early diabetic nephropathy...
  73. ncbi Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies
    Khalil El Karoui
    Department of Pathology, Hopital Europeen Georges Pompidou, Paris, France
    Kidney Int 79:643-54. 2011
    ..Hence, interpreting IgAN in terms of FSGS emphasizes the role that podocyte lesions may play in the pathogenesis and progression of this disease...
  74. pmc Multiphoton imaging of the glomerular permeability of angiotensinogen
    Daisuke Nakano
    Department of Pharmacology, Kagawa University, Kagawa, Japan
    J Am Soc Nephrol 23:1847-56. 2012
    ..These results strongly suggest that the vast majority of urinary angiotensinogen originates from the tubules rather than glomerular filtration...
  75. ncbi EMT and TGF-beta in renal fibrosis
    Masayuki Iwano
    First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara 634 8522, Japan
    Front Biosci (Schol Ed) 2:229-38. 2010
    ..During the past five years, detailed mechanisms by which TGF-beta1 induces EMT have been clarified, and novel therapeutic approaches targeting TGF-beta1-mediated EMT are now being proposed...
  76. pmc Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dev Biol 313:584-93. 2008
    ..Collectively, our studies demonstrate that podocyte beta1 integrin and ILK signaling is critical for postnatal development and function of the glomerular filtration apparatus...
  77. pmc Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies
    L A Trouw
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Immunol 132:32-9. 2003
    ..This deposition is stable for at least 2 weeks, causes complement activation, leucocyte influx and can lead to mild albuminuria...
  78. pmc Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis
    Bart Smeets
    Department of Pathology, Radboud University Nijmegen Medical Center, Geert Grooteplein 24, Nijmegen, Netherlands
    J Am Soc Nephrol 20:2593-603. 2009
    ....
  79. pmc Angiotensin I is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli
    Juan Carlos Q Velez
    Ralph H Johnson Veterans Affairs Medical Center, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 53:790-7. 2009
    ..Formation of these alternative Ang peptides may be critical to counterbalance the local actions of Ang II. Enhancement of these enzymatic activities may constitute potential therapeutic targets for Ang II-mediated glomerular diseases...
  80. pmc Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells
    Bart Smeets
    Department of Nephrology and Immunology, University Hospital of the Aachen University of Technology, Pauwelsstrasse 30, Aachen, Germany
    J Am Soc Nephrol 20:2604-15. 2009
    ..In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases...
  81. ncbi C3 glomerulopathy: a new classification
    Fadi Fakhouri
    Departement de Nephrologie, INSERM UMR643, CHU de Nantes, 1 Place Alexis Ricordeau, 44000 Nantes, France
    Nat Rev Nephrol 6:494-9. 2010
    ..In the future, it could help to identify individuals who might benefit from therapeutic inhibition of the complement system...
  82. ncbi 1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway
    Houqin Xiao
    Division of Nephrology, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangdong, PR China
    Am J Nephrol 30:34-43. 2009
    ..Given a rich literature identifying podocyte apoptosis as an early step in the pathophysiological progression to proteinuria and glomerulosclerosis, we hypothesized that vitamin D protects podocytes from undergoing apoptosis...
  83. ncbi Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause
    B Sis
    Laboratory Medicine and Pathology, and Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 7:1743-52. 2007
    ..The remaining 27%, mostly BD, may be a different disease or a stage in which A and C are undetectable...
  84. pmc Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats
    Akira Nishiyama
    Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Pharmacol Exp Ther 332:1072-80. 2010
    ..o.) decreased SBP but did not alter any renal parameters. These data indicate that MR blockade enhances the SBP-independent antiproteinuric effect of an ARB through inhibiting podocyte injury in type 2 diabetic rats...
  85. ncbi The spectrum of podocytopathies: a unifying view of glomerular diseases
    R C Wiggins
    Nephrology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0676, USA
    Kidney Int 71:1205-14. 2007
    ....
  86. ncbi Mild renal ischemia-reperfusion reduces charge and size selectivity of the glomerular barrier
    Maria Andersson
    Department of Nephrology, Goteborg University, Gothenburg, Sweden
    Am J Physiol Renal Physiol 292:F1802-9. 2007
    ....
  87. pmc Multiple factors influence glomerular albumin permeability in rats
    Ruben M Sandoval
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 23:447-57. 2012
    ..In summary, these results help explain the previously conflicting microscopy and micropuncture data describing albumin filtration and highlight the dynamic nature of glomerular albumin permeability...
  88. ncbi The aging kidney: a review -- part I
    Fred G Silva
    The United States and Canadian Academy of Pathology and the Medical College of Georgia, Emory University, 3643 Walton Way Extension, Building 6, Augusta, GA 30909, USA
    Int Urol Nephrol 37:185-205. 2005
  89. ncbi Reversal of glomerular lesions involves coordinated restructuring of glomerular microvasculature
    Marcin Adamczak
    Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Francuska 20 24 Street, 40 027 Katowice, Poland
    J Am Soc Nephrol 15:3063-72. 2004
    ..Proportionate reduction of glomerular volume and capillary number without change of individual capillary length were found. The numerical capillary density of the tuft therefore remained unchanged...
  90. pmc Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model
    Michael S Forbes
    Dept of Pediatrics, University of Virginia, Box 800386, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 301:F110-7. 2011
    ....
  91. pmc High glucose causes dysfunction of the human glomerular endothelial glycocalyx
    A Singh
    Academic Renal Unit, Learning and Research Bldg, Clinical Sciences North Bristol, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK
    Am J Physiol Renal Physiol 300:F40-8. 2011
    ....
  92. ncbi Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats
    Perla D Maldonado
    Department of Biology, Faculty of Chemistry, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 D F, Mexico, Mexico
    Life Sci 73:2543-56. 2003
    ..These data suggest that AGE may be a useful agent for the prevention of GM-nephrotoxicity...
  93. ncbi C4d peritubular capillary staining in chronic allograft nephropathy and transplant glomerulopathy: an uncommon finding
    Ziyad Al Aly
    Division of Nephrology, Saint Louis University, St Louis, MO 63110, USA
    Transpl Int 18:800-5. 2005
    ..None of the TGP biopsies showed peritubular C4d staining. C4d staining of the peritubular capillaries appears to be rare in patients with pure CAN with and without TGP features...
  94. ncbi Functional consequences of integrin-linked kinase activation in podocyte damage
    Vicente de Paulo Castro Teixeira
    Medizinische Poliklinik, Universitat Munchen, Munich, Germany
    Kidney Int 67:514-23. 2005
    ..The aim of this study was to elucidate the molecular mechanisms of ILK dependant phenotype regulation in podocytes...
  95. ncbi The clinical significance of hyperfiltration in diabetes
    G Jerums
    Endocrine Centre, Austin Health, Heidelberg Repatriation Hospital, Level 2, Centaur Building, 300 Waterdale Road, PO Box 5444, Heidelberg West, Victoria 3081, Australia
    Diabetologia 53:2093-104. 2010
    ..Future studies will therefore need to address the independent role of hyperfiltration, not only in the evolution of albuminuria, but also in the subsequent decline of GFR...
  96. pmc Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling
    Marina Shkreli
    Department of Medicine, Stanford School of Medicine, Stanford, California, USA
    Nat Med 18:111-9. 2012
    ....
  97. pmc Combination of peritubular c4d and transplant glomerulopathy predicts late renal allograft failure
    Niamh Kieran
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, Washington 98195 6521, USA
    J Am Soc Nephrol 20:2260-8. 2009
    ....
  98. pmc Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease
    Daniel T Meehan
    Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Kidney Int 76:968-76. 2009
    ..We suggest that MMP and cytokine dysregulation may constitute a maladaptive response to biomechanical strain in the podocytes of Alport patients, thus contributing to glomerular disease initiation and progression...
  99. pmc Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis
    Katharina Flür
    Medical Policlinic, University of Munich, Germany
    Am J Pathol 175:2014-22. 2009
    ..Thus, TLR-independent recognition of viral RNA is a potent inducer of type I interferon in mesangial cells, which can be an important mediator of virally induced glomerulonephritis...
  100. pmc Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298, USA
    Hypertension 53:90-6. 2009
    ..We concluded that Vav2-mediated activation of NADPH oxidase is an important initiating mechanism resulting in hyperhomocysteinemic glomerular injury through enhanced local oxidative stress...
  101. ncbi Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists
    H J Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Munich, Germany
    Kidney Int 69:29-32. 2006
    ..In fact, blocking CCR-1 with specific small-molecule antagonists was shown to retard progression in various types of rodent CKD models. Here we discuss the perspective of CCR-1 as a new potential target for the treatment of CKD...

Research Grants66

  1. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..flow rates and under the same conditions a and d in Aim 1, and in cultured cell monolayer of lung and brain, kidney glomerulus and skeleton muscle microvascular endothelial cells under the same conditions a and d in Aim 1;and 4) ..
  2. Alpha actinin 4: its functions and regulation
    Hung Ying Kao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Podocytes are highly differentiated epithelial cells in the kidney glomerulus that possess extensively branched cell processes, interdigitating into the unique foot processes and slit diaphragms ..
  3. Angiotensin Metabolite Formation by Podocytes: Implications in Glomerular Injury
    Juan Carlos Q Velez; Fiscal Year: 2013
    ..series of experiments that will yield insight into mechanisms of hormonal regulation within the kidney glomerulus and their relationship with pathways that lead to progressive kidney diseases...
  4. High Pressure Freezer for Improved Ultrastructure
    David Hall; Fiscal Year: 2003
    ..Lisanti), the distribution of mRNAs in yeast (Dr. Singer), and podocytes in the kidney glomerulus of knockout mice (Dr. Mundel)...
  5. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  6. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  7. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  8. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2003
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  9. Pathology of the FSGS Kidney
    Agnes B Fogo; Fiscal Year: 2010
    ..These approaches could ultimately identify novel therapeutic targets in FSGS. ..
  10. Laminin Alpha5 and Polycystic Kidney Disease
    JEFFREY MINER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  12. Mechanisms of Cell/Matrix Interactions in the Kidney
    JEFFREY MINER; Fiscal Year: 2006
    ..Together, the results of these studies will lead to a more complete understanding of cell-matrix interactions in the kidney and could reveal new avenues for diagnosis and treatment of human kidney disease. ..
  13. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  14. 2008 Basement Membranes Gordon Research Conference
    JEFFREY MINER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. COLLAGEN IV CHAINS IN KIDNEY DEVELOPMENT AND FUNCTION
    JEFFREY MINER; Fiscal Year: 2002
    ..The results obtained under the auspices of this proposal will have important implication for the pathogenesis of Alport syndrome in man and for approaches current under development that will use gene therapy to treat the human disease. ..
  16. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  17. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..Studies on the genetic analyses of basement membrane functions and the generation of animal models of human basement membrane disorders will be presented. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. ASSEMBLY AND FUNCTION OF BASEMENT MEMBRANE PROTEINS
    JEFFREY MINER; Fiscal Year: 2008
    ..The results of these studies will lead to new information regarding the assembly and function of laminins in the in vivo setting. ..
  19. 5TH INTERNATIONAL PODOCYTE CONFERENCE
    Stuart Shankland; Fiscal Year: 2004
    ..3. To facilitate cross-talk between clinicians and scientists with the ultimate goal of improving prognosis, treatment and care of patients with glomerular disease. ..
  20. RECEPTOR/LIGAND SIGNALS FOR KIDNEY VASCULAR DEVELOPMENT
    Dale Abrahamson; Fiscal Year: 2008
    ..These results should provide fundamentally new information on mechanisms governing renal microvessel development and maintenance, which may have broad applicability to blood vessel formation in general. ..
  21. MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEM
    Janos Peti Peterdi; Fiscal Year: 2008
    ..This multi-photon core is also critically needed for the USC Diabetes Research Center and the Clinical and Translational Science Institute, both being established pending PHS grants. [unreadable] [unreadable] [unreadable]..
  22. Iron and Vitamin E in Childhood HIV-Associated Renal Disease
    Patricio Ray; Fiscal Year: 2006
    ..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. [unreadable] [unreadable]..
  23. LAMININ IN DEVELOPING GLOMERULAR BASEMENT MEMBRANES
    Dale Abrahamson; Fiscal Year: 2003
    ..These studies will provide fundamentally new information on glomerular development and maintenance. ..
  24. Nephron Count, Birth Weight & Hypertensive Renal Disease
    Michael Hughson; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  25. The Aging Glomerulus
    Jocelyn Wiggins; Fiscal Year: 2008
    ..abstract_text> ..
  26. Renin activation in early diabetes
    Janos Peti Peterdi; Fiscal Year: 2009
    ..These studies should yield clinically important information that can be used to develop new drugs and therapeutic approaches for the better treatment of diabetic complications in the kidney as well as high blood pressure. ..
  27. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..We will also determine the mitochondrial metabolic effects that are most critical to both hypoxia-induced apoptosis and glucose protection in VSMCs. ..
  28. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ....
  29. Proteomics in Type 1 Diabetes and its Complications
    S Mauer; Fiscal Year: 2005
    ..These studies could provide surrogate markers of DN and TIDM risk and provide insights into the pathogenesis of TIDM and its renal complications. ..
  30. Ischemia-induced Actin Cytoskeletal Alterations
    Bruce Molitoris; Fiscal Year: 2008
    ..abstract_text> ..
  31. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2008
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  32. Urinary Podocyte Excretion Using FACS Methodology
    Kevin Lemley; Fiscal Year: 2003
    ..e. is podocyturia an earlier biomarker of incipient nephropathy? and 2) do the responses of albuminuria and podocyturia to treatment with angiotensin-converting enzyme inhibitors differ? ..
  33. PHYSICO-CHEMICAL ASPECTS OF RENAL TRANSPORT PROCESSES
    William Deen; Fiscal Year: 2004
    ..abstract_text> ..
  34. Genetic Epidemiology Of Kidney Anomalies
    Abhay Vats; Fiscal Year: 2004
    ..We wish to pursue further gene localization studies on chromosome 13 in this application in order to identify the causative genes. ..
  35. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  36. PATHOGENESIS OF HIV ASSOC THROMBOTIC MICROANGIOPATHY
    CHARLES ALPERS; Fiscal Year: 2003
    ..abstract_text> ..
  37. Non-Invasive Optical Determination of GFR
    Bruce Molitoris; Fiscal Year: 2008
    ..This has limited the ability to effectively test potential new therapies. PharmacoPhotonics, LLC is developing a non-invasive optical technique to meet this need. [unreadable] [unreadable] [unreadable]..
  38. Biotechnology Center for Comparative Genomics
    CHARLES ALPERS; Fiscal Year: 2003
    ..abstract_text> ..
  39. Decoupling of Principal Renal Autoregulatory Mechanisms
    Ki Chon; Fiscal Year: 2005
    ..By exercising this model, as described under Specific Aim (5), we plan to begin understanding the underlying reasons for the changes observed in autoregulation under pathological conditions. ..
  40. NITRIC OXIDE 'NO' AND THE KIDNEY
    Chris Baylis; Fiscal Year: 2003
    ..Finally, she will evaluate the validity of the use of plasma and urinary NOX and will use Electron Spin Resonance (ESR) spectroscopy as an alternative method of determining NO production in vivo. ..
  41. Developing Predictive Methods for Sudden Cardiac Death
    Ki Chon; Fiscal Year: 2002
    ..It is intended that the algorithm will be applicable to other physiological systems and may become a widely accepted noninvasive clinical alternative. ..
  42. Signaling Pathways in Renal Fibrogenesis
    H Schnaper; Fiscal Year: 2008
    ..By elucidating the signaling events underlying kidney fibrosis we hope to better understand fibrogenic mechanisms and how to interrupt them. ..
  43. RAB5 AND PI-3-KINASE AND GENTAMICIN TOXICITY
    Bruce Molitoris; Fiscal Year: 2002
    ..By performing these studies, it is hoped that formulation of specific therapies to delay and/or inhibit this toxicity will become possible. ..
  44. ESTROGEN AND ENDOTHELIAL MIGRATION AND DIFFERENTIATION
    H Schnaper; Fiscal Year: 2002
    ..These studies will elucidate regulatory effects of estradiol on endothelial cell function. ..
  45. CELLULAR PHENOTYPES OF SALT SENSITIVITY
    Abraham Aviv; Fiscal Year: 2001
    ..The investigators state that the results of the study will generate a novel perspective about phenotypes of salt sensitivity and, an insight into the cardiovascular effects of high salt in humans. ..
  46. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  47. Control of Tumor Growth by the MMP/Angiostatin Pathway
    Ambra Pozzi; Fiscal Year: 2007
    ..These studies will help us to determine how stinaulation of the MMP/angiostatin axis can be used as a tool to inhibit specifically tumor vaseularization and growth. ..
  48. CYSTIC DILATATION OF NEPHRONS IN TRANSGENIC INV MICE
    Carrie Phillips; Fiscal Year: 2005
    ..Second, we will identify crucial binding partners of inversin in these cultured systems by blocking in vitro translation and assaying for changes in PKD-associated proteins. ..
  49. TGF-beta and Cytoskeletal Signaling in Mesangial Cell
    H Schnaper; Fiscal Year: 2005
    ..These studies will determine whether increased cytoskeletal tension is required for RGTPase effects on collagen expression. ..
  50. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  51. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  52. GENETIC EPIDEMIOLOGY OF IDIOPATHIC NEPHROTIC SYNDROME
    Abhay Vats; Fiscal Year: 2005
    ....
  53. CYSTIC DILATATION OF NEPHRONS IN TRANSGENIC INV MICE
    Carrie Phillips; Fiscal Year: 2005
    ..We believe the inv/inv model offers a new an exciting opportunity to extend the understanding of the genetic mechanisms of nephrogenesis and the abnormalities in this process which lead to PKD. ..
  54. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  55. Renal & Cellular Studies in Type 1 Diabetic Patients
    S Mauer; Fiscal Year: 2007
    ..These studies will provide markers and predictors of DN risk, determine if these are genetically regulated or dependent on prior exposure to D, and identify DN pathogenetic pathways. ..
  56. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Stretch-Induced Podocyte Injury
    Raghu Durvasula; Fiscal Year: 2007
    ..abstract_text> ..
  58. Renin Angiotensin System Blockage-DN (RASS)
    S Mauer; Fiscal Year: 2007
    ..Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants' compliance. ..
  59. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2007
    ..abstract_text> ..
  60. Decoupling Dynamics of the Autonomic Nervous System
    Ki Chon; Fiscal Year: 2005
    ..abstract_text> ..
  61. Mitochondrial and Oxidative Stress in Type 1 Diabetes
    S Mauer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  62. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2008
    ..abstract_text> ..
  63. Mechanism of Mechanoreceptor Inhibition by Aldosterone
    Heather Drummond; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  64. PATHOPHYSIOLOGY OF DIABETIC NEPHROPATHY
    Sharon Anderson; Fiscal Year: 2007
    ..abstract_text> ..
  65. PATHOPHYSIOLOGY OF THE AGING KIDNEY
    Sharon Anderson; Fiscal Year: 2001
    ..The use of a combined physiological, biochemical, immunohistochemical, and molecular biologic approach should gain insight into this clinically important but understudied problem. ..