ovarian follicle

Summary

Summary: An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.

Top Publications

  1. ncbi TGF-beta superfamily members and ovarian follicle development
    Phil G Knight
    School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Reproduction 132:191-206. 2006
  2. ncbi Derivation of oocytes from mouse embryonic stem cells
    Karin Hübner
    Germline Development Group, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA
    Science 300:1251-6. 2003
  3. ncbi Mechanisms maintaining the dormancy and survival of mammalian primordial follicles
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Trends Endocrinol Metab 21:96-103. 2010
  4. ncbi Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes
    Irma Virant-Klun
    Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Differentiation 76:843-56. 2008
  5. pmc Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
    Yvonne A R White
    Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 18:413-21. 2012
  6. ncbi Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)
    James P Hanrahan
    Teagasc, Research Centre, Athenry, County Galway, Ireland
    Biol Reprod 70:900-9. 2004
  7. ncbi Germline stem cells and follicular renewal in the postnatal mammalian ovary
    Joshua Johnson
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:145-50. 2004
  8. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
  9. pmc Gene bionetwork analysis of ovarian primordial follicle development
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 5:e11637. 2010
  10. pmc Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly
    Eric E Nilsson
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 6:e20087. 2011

Detail Information

Publications306 found, 100 shown here

  1. ncbi TGF-beta superfamily members and ovarian follicle development
    Phil G Knight
    School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    Reproduction 132:191-206. 2006
    ....
  2. ncbi Derivation of oocytes from mouse embryonic stem cells
    Karin Hübner
    Germline Development Group, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA
    Science 300:1251-6. 2003
    ..Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies on fertility treatment and germ and somatic cell interaction and differentiation...
  3. ncbi Mechanisms maintaining the dormancy and survival of mammalian primordial follicles
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Trends Endocrinol Metab 21:96-103. 2010
    ..Here we summarize this updated information, which hopefully will lead to a better understanding of the pathophysiology of the human ovary and provide potential therapeutic options for some types of infertility...
  4. ncbi Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes
    Irma Virant-Klun
    Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Differentiation 76:843-56. 2008
    ..These findings could be used for further studies aimed at the autologous treatment of ovarian infertility and degenerative diseases...
  5. pmc Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
    Yvonne A R White
    Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 18:413-21. 2012
    ..Thus, ovaries of reproductive-age women, similar to adult mice, possess rare mitotically active germ cells that can be propagated in vitro as well as generate oocytes in vitro and in vivo...
  6. ncbi Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)
    James P Hanrahan
    Teagasc, Research Centre, Athenry, County Galway, Ireland
    Biol Reprod 70:900-9. 2004
    ..Sterile ewes, due to a failure of normal ovarian follicle development, occur in both breeds...
  7. ncbi Germline stem cells and follicular renewal in the postnatal mammalian ovary
    Joshua Johnson
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:145-50. 2004
    ..Collectively, these data establish the existence of proliferative germ cells that sustain oocyte and follicle production in the postnatal mammalian ovary...
  8. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..Our results also show that cell proliferation in the prostate and urinary bladder of old ERbetaKO and ERalphabetaKO males is apparently normal...
  9. pmc Gene bionetwork analysis of ovarian primordial follicle development
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 5:e11637. 2010
    ..This is one of the first applications of network analysis to a normal developmental process. These observations provide insights into potential therapeutic targets for preventing ovarian disease and promoting female reproduction...
  10. pmc Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly
    Eric E Nilsson
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 6:e20087. 2011
    ....
  11. ncbi AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
    S L Broer
    Department of Reproductive Medicine and Gynecology, University Medical Center, GA Utrecht, The Netherlands
    Hum Reprod Update 17:46-54. 2011
    ..The aim of this study was to assess the accuracy of AMH and antral follicle count (AFC) as predictors of an excessive response in IVF/ICSI treatment...
  12. pmc Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary
    Lucy X Morris
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Development 138:2207-15. 2011
    ..Additionally, escort cells are not replenished by the regular division of escort stem cells as previously suggested. Rather, escort cells remain quiescent and divide only to maintain a constant germ cell:escort cell ratio...
  13. ncbi Intercellular communication in the mammalian ovary: oocytes carry the conversation
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 296:2178-80. 2002
    ..mature eggs have fascinated biologists for centuries, and scientists have long realized the importance of the ovarian follicle's somatic cells in nurturing oogenesis and delivering the oocyte to the oviduct by ovulation...
  14. ncbi How can female germline stem cells contribute to the physiological neo-oogenesis in mammals and why menopause occurs?
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Microsc Microanal 17:498-505. 2011
    ....
  15. ncbi Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve
    I A J van Rooij
    Department of Reproductive Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Hum Reprod 17:3065-71. 2002
    ..Therefore, we studied the relationship between AMH levels and ovarian response during ovarian stimulation for IVF...
  16. ncbi Growth differentiation factor-9 is required during early ovarian folliculogenesis
    J Dong
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 383:531-5. 1996
    ..Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised. Thus, GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo...
  17. ncbi Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary
    A L Durlinger
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, The Netherlands
    Endocrinology 140:5789-96. 1999
    ..The female AMH null mouse may thus provide a useful model to study regulation of primordial follicle recruitment and the relation between follicular dynamics and ovarian aging...
  18. ncbi Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 15:201-4. 1997
    ..Our findings have important implications for male contraceptive development in humans...
  19. pmc Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
    Yuichi Niikura
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 1:971-8. 2009
    ..Thus, aged mouse ovaries possess a rare population of premeiotic germ cells that retain the capacity to form oocytes if exposed to a young host environment...
  20. ncbi Formation of the ovarian follicular antrum and follicular fluid
    Raymond J Rodgers
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 82:1021-9. 2010
    ..Remodeling of the stroma and thecal layers also accompanies growth and expansion of the antrum and presumably involves similar processes that accompany growth of other glands...
  21. ncbi The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count
    Simone L Broer
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology, and Gynecology, University Medical Center, Utrecht, The Netherlands
    Fertil Steril 91:705-14. 2009
    ..To assess the value of antimullerian hormone (AMH) as a test to predict poor ovarian response and pregnancy occurrence after IVF and to compare it with the performance of the antral follicle count (AFC)...
  22. ncbi Apoptosis in the ovary: molecular mechanisms
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Assiut, Egypt
    Hum Reprod Update 11:162-77. 2005
    ..It also presents the existing literature and assesses the gaps in our knowledge...
  23. ncbi Regulation of ovarian function: the role of anti-Müllerian hormone
    Alexandra L L Durlinger
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 124:601-9. 2002
    ....
  24. ncbi Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary
    Alexandra L L Durlinger
    Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Endocrinology 143:1076-84. 2002
    ..Based on the results, we suggest that AMH inhibits initiation of primordial follicle growth and therefore functions as an inhibitory growth factor in the ovary during these early stages of folliculogenesis...
  25. ncbi Development of primordial follicles in the hamster: role of estradiol-17beta
    Cheng Wang
    Department of Obstetrics, Durham Research Center, University of Nebraska Medical Center, 984515 Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 148:1707-16. 2007
    ..This supportive action of E2 is lost when hormone levels increase above a threshold...
  26. ncbi Primordial follicular assembly in humans--revisited
    A Maheshwari
    University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen AB25 2ZL, Scotland, UK
    Zygote 16:285-96. 2008
    ..Hence, we feel it is time to take a step back and see what is available in the literature and identify the gaps in which future research about primordial follicle assembly in humans needs to be directed...
  27. ncbi Growth differentiation factor 9 and its spatiotemporal expression and regulation in the zebrafish ovary
    Lin Liu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biol Reprod 76:294-302. 2007
    ..In conclusion, as an oocyte-derived growth factor, GDF9 is highly conserved across vertebrates. With its biological advantages, zebrafish provides an alternative model for studying gene function and regulation...
  28. ncbi Oocyte control of ovarian follicular development and function in mammals
    J J Eppig
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Reproduction 122:829-38. 2001
    ....
  29. ncbi Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary
    Horacio A Rodríguez
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, Ciudad Universitaria, Paraje El Pozo, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, CP 3000 Santa Fe, Argentina
    Reprod Toxicol 30:550-7. 2010
    ..Results show that BPA reduces the primordial follicle pool by stimulating the neonatal initial recruitment, associated with an increased proliferation rate likely mediated by an estrogenic pathway...
  30. ncbi Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
    Seung Pyo Gong
    Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    Fertil Steril 93:2594-601, 2601.e1-9. 2010
    ..To suggest an alternative strategy for deriving histocompatible stems cells without undertaking genetic manipulation...
  31. ncbi The antral follicle count: practical recommendations for better standardization
    Frank J M Broekmans
    Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Fertil Steril 94:1044-51. 2010
    ..In addition, there is considerable variability in the clinical definitions and technical methods used to count and measure antral follicles in both published studies and clinical practice...
  32. ncbi Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production
    Claire Glister
    School of Biological Sciences, Hopkins Building, University of Reading, Whiteknights, Reading RG6 6UB, UK
    Reproduction 140:699-712. 2010
    ....
  33. ncbi The role of luteinizing hormone in regulating gene expression during selection of a dominant follicle in cattle
    Wenxiang Luo
    Endocrinology Reproductive Physiology Program and Department of Dairy Science, University of Wisconsin, Madison, Wisconsin, USA
    Biol Reprod 84:369-78. 2011
    ..Production of follicular A(4), testosterone, and E(2) are also acutely related to LH but due to changes in expression of STAR and CYP17A1 in TC...
  34. ncbi Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles
    Deepak Adhikari
    Department of Medical Biochemistry and Biophysics, Umeå University SE 901 87, Umea, Sweden
    Mol Hum Reprod 15:765-70. 2009
    ..Our results also indicate that deregulation of Tsc/mTOR signaling in oocytes may cause pathological conditions of the ovary such as infertility and POF...
  35. pmc Induction of ovarian primordial follicle assembly by connective tissue growth factor CTGF
    Ryan Schindler
    Center for Reproductive Biology, School Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 5:e12979. 2010
    ..These observations suggest the possibility of manipulating primordial follicle pool size and influencing female reproductive lifespan...
  36. ncbi Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 57:195-220. 2002
    ..Whereas PR appears to regulate the induction of novel proteases, COX-2 appears to regulate cumulus expansion. This review summarizes some new aspects of peptide and steroid hormone signaling in the rodent ovary...
  37. ncbi Development of the ovarian follicular epithelium
    R J Rodgers
    Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
    Mol Cell Endocrinol 151:171-9. 1999
    ..This basic information will be important for the development of future reproductive technologies in both humans and animals, and possibly for understanding polycystic ovarian syndrome in women...
  38. ncbi Oocyte-somatic cell interactions during follicle development in mammals
    R B Gilchrist
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia
    Anim Reprod Sci 82:431-46. 2004
    ..Elucidating the nature of oocyte-somatic cell interactions at the various stages of follicle development will have important implications for our understanding of factors regulating folliculogenesis, ovulation rate and fecundity...
  39. ncbi Parthenogenetic embryo-like structures in the human ovarian surface epithelium cell culture in postmenopausal women with no naturally present follicles and oocytes
    Irma Virant-Klun
    Department of Obstetrics and Gynecology, University Medical Centre, Ljubljana, Slovenia
    Stem Cells Dev 18:137-49. 2009
    ..In conclusion, the discovered cells expressed embryonic stem cell markers, gave rise to embryoid body-, oocyte-, and blastocyst-like structures, and might be involved in the human reproduction and formation of ovarian tumors...
  40. ncbi Drosophila oocyte localization is mediated by differential cadherin-based adhesion
    D Godt
    Department of Zoology, University of Toronto, Ontario, Canada
    Nature 395:387-91. 1998
    ..This is, to our knowledge, the first in vivo example of a cell-sorting process that depends on differential adhesion mediated by a cadherin...
  41. pmc Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
    Deepak Adhikari
    1Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    Hum Mol Genet 19:397-410. 2010
    ..Deregulation of these signaling pathways in oocytes results in pathological conditions of the ovary, including POF and infertility...
  42. ncbi Dynamic assays of inhibin B, anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome
    Talia Eldar-Geva
    IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Ben Gurion University of the Negev, Jerusalem 91031, Israel
    Hum Reprod 20:3178-83. 2005
    ....
  43. ncbi Notch pathway genes are expressed in mammalian ovarian follicles
    J Johnson
    Department of Biology, Arizona State University, Tempe, AZ 85287-1501, USA
    Mech Dev 109:355-61. 2001
    ..Jagged1 was expressed in oocytes exclusively. Downstream target genes of Notch also were expressed in granulosa cells. These data implicate the Notch signaling pathway in the regulation of mammalian folliculogenesis...
  44. ncbi Anti-Müllerian hormone and folliculogenesis
    Jenny A Visser
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Endocrinol 234:81-6. 2005
    ..Besides its functional role in the ovary, AMH serum level serves as an excellent candidate marker of ovarian reserve...
  45. ncbi Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts
    J van Disseldorp
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, PO Box 85500, Room F 05 126, 3508 GA Utrecht, The Netherlands
    Hum Reprod 25:221-7. 2010
    ..The best ovarian reserve test would need only a single, cycle-independent measurement to be representative...
  46. ncbi A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause
    Karl R Hansen
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Hum Reprod 23:699-708. 2008
    ..To better characterize the decline in NGF number associated with aging, we have employed modern stereology techniques to determine NGF number in women from birth to menopause...
  47. ncbi Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level
    Dave J Hendriks
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 83:291-301. 2005
    ..To assess the predictive performance of the antral follicle count (AFC) as a test for ovarian reserve in IVF patients and to compare this performance with that of basal FSH level...
  48. pmc Vascular endothelial growth factor receptor 2-mediated angiogenesis is essential for gonadotropin-dependent follicle development
    Ralf C Zimmermann
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 112:659-69. 2003
    Gonadotropins induce ovarian follicle growth that is coincident with increased follicular vasculature, suggesting a role of angiogenesis in follicle development...
  49. ncbi Mouse ovarian germ cell cysts undergo programmed breakdown to form primordial follicles
    M E Pepling
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 115 W. University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 234:339-51. 2001
    ..Cysts may ensure that oocytes destined to form primordial follicles acquire populations of functional mitochondria, through an active process that has been evolutionarily conserved...
  50. ncbi A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin
    Evelyn E Telfer
    Institute of Cell Biology, The Darwin Building, University of Edinburgh, The King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Hum Reprod 23:1151-8. 2008
    ....
  51. ncbi Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult
    D W Schomberg
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 140:2733-44. 1999
    ..The presence of ER beta in the granulosa cells did not rescue the phenotype of the ovary...
  52. ncbi Regulation of primordial follicle assembly and development
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Hum Reprod Update 11:461-71. 2005
    ..Elucidation of the molecular and cellular control of primordial follicle assembly and the primordial to primary follicle transition provides therapeutic targets to regulate ovarian function and treat ovarian disease...
  53. pmc Activation of dormant ovarian follicles to generate mature eggs
    Jing Li
    Department of Obstetrics and Gynecology, Program of Reproductive and Stem Cell Biology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 107:10280-4. 2010
    ..Generation of a large number of human oocytes also facilitates future derivation of embryonic stem cells for regenerative medicine...
  54. ncbi Notch signaling is involved in ovarian follicle development by regulating granulosa cell proliferation
    Chun Ping Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Endocrinology 152:2437-47. 2011
    ..In conclusion, Notch signaling is involved in follicular development by regulating granulosa cell proliferation...
  55. ncbi Identification of genes involved in apoptosis and dominant follicle development during follicular waves in cattle
    A C O Evans
    Department of Animal Science and Production and the Centre for Integrative Biology, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biol Reprod 70:1475-84. 2004
    ....
  56. pmc Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation
    Tiffiney R Hartman
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Cell Biol 191:943-52. 2010
    ..Our studies demonstrate that cells distant from the local niche can regulate stem cell function through ligand sequestration, a mechanism that likely is conserved in other epithelial tissues...
  57. ncbi Female infertility in mice lacking connexin 37
    A M Simon
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 385:525-9. 1997
    The signals regulating ovarian follicle development and the mechanisms by which they are communicated are largely undefined...
  58. ncbi Follicular assembly: mechanisms of action
    Melissa E Pepling
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    Reproduction 143:139-49. 2012
    ..Elucidation of mechanisms leading to formation of the primordial follicle pool will help research efforts in ovarian biology and improve treatments of female infertility, premature ovarian failure, and reproductive cancers...
  59. ncbi PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umeå University SE 901 87, Umea, Sweden
    Hum Mol Genet 18:2813-24. 2009
    ..Underactivation or overactivation of this signaling pathway in oocytes is shown to cause pathological conditions in the ovary, including POF and infertility...
  60. ncbi Molecular mechanisms underlying the activation of mammalian primordial follicles
    Deepak Adhikari
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    Endocr Rev 30:438-64. 2009
    ..These advances may provide a better understanding of human ovarian physiology and pathophysiology for future clinical applications...
  61. ncbi Theca: the forgotten cell of the ovarian follicle
    J M Young
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, UK
    Reproduction 140:489-504. 2010
    ....
  62. ncbi Gap junctions and ovarian folliculogenesis
    Gerald M Kidder
    Department of Physiology, The University of Western Ontario, London, N6A 5C1, Canada
    Reproduction 123:613-20. 2002
    ..The expression of multiple connexins in developing follicles is thus likely to reflect the multiple functions served by gap junctional communication in folliculogenesis...
  63. ncbi Circulating basal anti-Müllerian hormone levels as predictor of ovarian response in women undergoing ovarian stimulation for in vitro fertilization
    Luciano G Nardo
    Department of Reproductive Medicine, St Mary s Hospital, Manchester, United Kingdom
    Fertil Steril 92:1586-93. 2009
    ..To evaluate the clinical value of basal anti-Müllerian hormone (AMH) measurements compared with other available determinants, apart from chronologic age, in the prediction of ovarian response to gonadotrophin stimulation...
  64. ncbi From primordial germ cell to primordial follicle: mammalian female germ cell development
    Melissa E Pepling
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    Genesis 44:622-32. 2006
    ..This phase of oocyte differentiation is poorly understood but molecules and mechanisms that regulate oocyte development are beginning to be identified. This review focuses on these early stages of female germ cell development...
  65. pmc Glycomic analyses of ovarian follicles during development and atresia
    Nicholas Hatzirodos
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, SA, 5005, Australia
    Matrix Biol 31:45-56. 2012
    ..The heparan sulfate products detected in the follicles are likely to be associated with perlecan, collagen XVIII or betaglycan...
  66. ncbi Data-driven assessment of the human ovarian reserve
    T W Kelsey
    School of Computer Science, University of St Andrews, St Andrews KY16 9SX, UK
    Mol Hum Reprod 18:79-87. 2012
    ....
  67. ncbi Postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls
    Tanja Kuiri-Hänninen
    Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, FI 70211 Kuopio, Finland
    J Clin Endocrinol Metab 96:3432-9. 2011
    ..Postnatal pituitary-testicular activation in infant boys is well characterized. However, the ovarian response to pituitary activation in infancy is less well understood...
  68. ncbi Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early post partum
    J L M R Leroy
    Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Theriogenology 62:1131-43. 2004
    ....
  69. ncbi NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:1157-9. 2004
    ..Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development...
  70. ncbi Concentration of activin A and follistatin in follicular fluid from human small antral follicles associated to gene expression of the corresponding granulosa cells
    J V Jeppesen
    Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children, and Reproduction Copenhagen University Hospital, Copenhagen University, Denmark
    Mol Cell Endocrinol 356:48-54. 2012
    ..This study revealed unexpected associations that probably reflect the complicated regulatory mechanisms governing human folliculogenesis...
  71. ncbi Forkhead transcription factors in ovarian function
    Nina Henriette Uhlenhaut
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    Reproduction 142:489-95. 2011
    ....
  72. ncbi Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy
    Elpida Fragouli
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford OX3 9DU, UK
    Hum Reprod 27:2559-68. 2012
    ..During this investigation, we aimed to obtain an insight into the follicular environment of oocytes that become aneuploid and identify non-invasive markers of oocyte chromosome status and competence...
  73. pmc The ovary: basic biology and clinical implications
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Clin Invest 120:963-72. 2010
    The classical view of ovarian follicle development is that it is regulated by the hypothalamic-pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the release of the gonadotropic hormones follicle-stimulating ..
  74. pmc Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells
    Carla Pelusi
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Biol Reprod 79:1074-83. 2008
    ..These findings demonstrate that SF-1 has a key role in female reproduction via essential actions in granulosa cells...
  75. ncbi Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity
    Alexander P Sobinoff
    Reproductive Science Group, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Toxicol Sci 128:258-71. 2012
    ..In this study, we examined the effects of 3MC exposure on the immature ovarian follicle population...
  76. ncbi Global gene analysis of oocytes from early stages in human folliculogenesis shows high expression of novel genes in reproduction
    S Markholt
    Department of Biomedicine, Aarhus University, Ole Worms Allé 3, DK 8000 Aarhus, Denmark
    Mol Hum Reprod 18:96-110. 2012
    ....
  77. ncbi Expression of genes associated with retinoid metabolism in the trout ovarian follicle
    Liraz Levi
    Department of Marine Biology and Biotechnology, Israel Oceanographic and Limnological Research, Haifa, Israel
    Biol Reprod 79:570-7. 2008
    ....
  78. ncbi Vascular supply as a discriminating factor for pig preantral follicle selection
    A Martelli
    Department of Comparative Biomedical Sciences, University of Teramo, Teramo, Italy
    Reproduction 137:45-58. 2009
    ..The follicles with this high activity are probably able to reach class 6 becoming dominant structures where somatic and vascular parameters are constantly on high levels and the VA remains the unique differentiating element...
  79. ncbi Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes
    Han Qiong Zhang
    Laboratory of Germ Cell Biology, Qingdao Agricultural University, Qingdao, 266109, China
    Mol Biol Rep 39:5651-7. 2012
    ..01). Decreased mRNA expression of specific meiotic genes including Stra8, Dmc1, Rec8 and Scp3 were observed. In conclusion, BPA exposure can affect the formation of primordial follicle by inhibiting meiotic progression of oocytes...
  80. ncbi Down-regulation of genes encoding steroidogenic enzymes and hormone receptors in late preovulatory follicles of the cow coincides with an accumulation of intrafollicular steroids
    Marika Nimz
    Forschungsbereich Molekularbiologie, Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Domest Anim Endocrinol 37:45-54. 2009
    ..Collectively, our data show that late preovulatory follicles have a transient and unique gene expression profile and are clearly different from both the preceding and subsequent (follicular and luteal, respectively) stages...
  81. ncbi Cell-secreted vesicles in equine ovarian follicular fluid contain miRNAs and proteins: a possible new form of cell communication within the ovarian follicle
    Juliano C da Silveira
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Biol Reprod 86:71. 2012
    Proper cell communication within the ovarian follicle is critical for the growth and maturation of a healthy oocyte that can be fertilized and develop into an embryo...
  82. pmc mTOR controls ovarian follicle growth by regulating granulosa cell proliferation
    James Yu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e21415. 2011
    ..Implications for the real-time regulation of follicle growth and dominance, including the consequences of increased numbers of aneuploid granulosa cells, are discussed...
  83. ncbi WNT signaling in ovarian follicle biology and tumorigenesis
    Alexandre Boyer
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Trends Endocrinol Metab 21:25-32. 2010
    ..This review covers our current knowledge of WNT signaling in ovarian follicles, highlighting both the great promise and the many unresolved questions of this emerging field of research...
  84. ncbi A systematic review of tests predicting ovarian reserve and IVF outcome
    F J Broekmans
    Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:685-718. 2006
    ..As poor ovarian response will provide some information on OR status, especially if the stimulation is maximal, entering the first cycle of IVF without any prior testing seems to be the preferable strategy...
  85. ncbi Effects of dietary fats differing in n-6:n-3 ratio fed to high-yielding dairy cows on fatty acid composition of ovarian compartments, follicular status, and oocyte quality
    M Zachut
    Department of Dairy Cattle, Institute of Animal Sciences, Volcani Center, PO Box 6, Bet Dagan, 50250 Israel
    J Dairy Sci 93:529-45. 2010
    ..These findings could be related to modifications of the fatty acid composition in plasma and ovarian compartments in response to dietary supplementation...
  86. ncbi Toxicity of chemotherapy and radiation on female reproduction
    Dror Meirow
    Division of Obstetrics and Gynecology, IVF Unit, Fertility Preservation Laboratory, Sheba Medical Center, Tel Aviv University, Israel
    Clin Obstet Gynecol 53:727-39. 2010
    ..Although the exact mechanisms of damage remain unclear, it is essential to better understand these mechanisms to develop methods to diminish ovarian injury...
  87. ncbi Culture of oocytes and risk of imprinting defects
    Ellen Anckaert
    Follicle Biology Laboratory, Centre for Reproductive Medicine, UZ Brussel, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Hum Reprod Update 19:52-66. 2013
    ..Finally, epigenetic analysis should be performed in children born from pregnancies after IVM to draw definitive conclusions on the epigenetic safety of human IVM...
  88. ncbi Differentiation potential of germ line stem cells derived from the postnatal mouse ovary
    Jason Pacchiarotti
    PrimeGen Biotech, Irvine, CA 92618, USA
    Differentiation 79:159-70. 2010
    ..This study shows the existence of a population of germ line stem cell in postnatal mouse ovary with multipotent characteristics...
  89. pmc Regulation of stem cells by intersecting gradients of long-range niche signals
    Cynthia Vied
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 23:836-48. 2012
    We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions...
  90. ncbi Influence of uterine bacterial contamination after parturition on ovarian dominant follicle selection and follicle growth and function in cattle
    I M Sheldon
    Department of Veterinary Clinical Science, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, UK
    Reproduction 123:837-45. 2002
    ..of the present study was to test the hypothesis that uterine bacterial contamination alters the location of ovarian follicle emergence and selection, and inhibits follicle growth and function...
  91. ncbi Cellular basis for paracrine regulation of ovarian follicle development
    D F Albertini
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Reproduction 121:647-53. 2001
    Paracrine factors secreted by oocytes and somatic cells regulate many important aspects of early ovarian follicle development in mammals...
  92. ncbi Anti-Müllerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro
    I B Carlsson
    Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Hum Reprod 21:2223-7. 2006
    ..Furthermore, the ovarian follicle pool diminishes prematurely in AMH-knockout mice...
  93. ncbi Human ovarian follicular development: from activation of resting follicles to preovulatory maturation
    A Gougeon
    INSERM U865, Anipath, Faculte de Medecine Laennec, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Ann Endocrinol (Paris) 71:132-43. 2010
    ..Thus, as the follicle develops, its responsiveness to gonadotropins progressively increases under the control of local factors acting in an autocrine/paracrine fashion...
  94. ncbi Activation of Akt (PKB) and suppression of FKHRL1 in mouse and rat oocytes by stem cell factor during follicular activation and development
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umea University, S 901 87, Umea, Sweden
    Dev Biol 281:160-70. 2005
    ....
  95. pmc Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation
    Minnie Hsieh
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e21574. 2011
    ..Thus, multiple signals and redundant pathways contribute to regulating oocyte reentry into the cell cycle...
  96. ncbi The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development
    Deidre Mattiske
    Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA
    Dev Biol 290:447-58. 2006
    ..We conclude that alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis...
  97. ncbi Ovarian stem cell niche and follicular renewal in mammals
    Antonin Bukovsky
    Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Anat Rec (Hoboken) 294:1284-306. 2011
    ..The parthenotes produce embryonic stem cells derived from inner cell mass, and these cells can serve as autologous pluripotent stem cells...
  98. ncbi Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults
    S Harel
    Infertility and IVF UnitHelen Schneider s Women Hospital, Rabin Medical Center, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Hum Reprod 12:357-65. 2006
    ..To elucidate whether indeed NT-4/5 and BDNF are involved in growth initiation of human primordial follicles, they should be added to the culture medium...
  99. pmc At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells
    Stephen Klusza
    Department of Biological Science, Florida State University, Tallahassee, FL, USA
    Bioessays 33:124-34. 2011
    ....
  100. ncbi Effect of insulin-like growth factor-I during preantral follicular culture on steroidogenesis, in vitro oocyte maturation, and embryo development in mice
    I Demeestere
    Research Laboratory on Human Reproduction and Fertility Clinic, Erasme Hospital, French Speaking Free University of Brussels, Belgium
    Biol Reprod 70:1664-9. 2004
    ..Moreover, the total cell number of the blastocysts observed after differential labeling staining was also higher when follicles were cultured or matured in the presence of IGF-I...
  101. ncbi Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice
    Karin A Slot
    Department of Animal Sciences, Human and Animal Physiology Group, Wageningen University, Haarweg 10, 6709 PJ Wageningen, The Netherlands
    Reproduction 131:525-32. 2006
    ..Furthermore, GH seems to protect antral follicles, directly or indirectly from undergoing atresia...

Research Grants68

  1. EGF RECEPTOR MEDIATED SIGNALING IN DROSOPHILA
    GERTRUD M SCHUPBACH; Fiscal Year: 2013
    ..during oogenesis, and the cellular pathways that mediate the response to this receptor tyrosine kinase in the ovarian follicle cells. Cell-cell communication plays an important role in the development of many tissues...
  2. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..in ovarian somatic cells, there is no report demonstrating the ability of Wnt ligands in the promotion of ovarian follicle growth...
  3. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Increased vascularity occurs during normal ovarian follicle development, and studies show that blood vessel growth (angiogenesis) is activated in ovarian carcinomas...
  4. Somatic stem cells in the Drosophila ovary
    DANIEL D KALDERON; Fiscal Year: 2013
    ..We propose extensive molecular genetic analyses of Drosophila ovarian follicle stem cells, which can be studied in great detail in their normal environment...
  5. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2013
    ..controlled maturation of the oocyte, supporting granulosa cells (GCs), and theca cells that comprise the ovarian follicle. Nutrients and hormones to support follicle maturation come from capillaries in the theca layer;..
  6. Center for Reproductive Research at Northwestern University
    Teresa K Woodruff; Fiscal Year: 2012
    ..The purpose of our center is to explore ovarian follicle dynamics from the perspective of structure-function relationships of the follicle unit and the hormones that ..
  7. FSH-STIMULATED SIGNALS THAT REGULATE FOLLICULAR MATURATION
    John H Nilson; Fiscal Year: 2013
    ..controlled maturation of the oocyte, supporting granulosa cells (GCs), and thecal cells that comprise the ovarian follicle. Follicle growth is a dynamic process that demands exquisite regulation...
  8. Gonadotropins &Cox-2 in Ovarian Cancer Prevention
    XIANGXI MIKE XU; Fiscal Year: 2013
    ..In preliminary experiments, suppression of Cox-1 was found to delay ovarian follicle depletion in addition to suppressing tumor development...
  9. Developmental Gene-Environment Interactions and Premature Ovarian Failure
    Ulrike Luderer; Fiscal Year: 2013
    ..The specific aims are: (1) To examine the roles of reactive oxygen species and oxidative damage in premature ovarian follicle depletion and poor oocyte quality in a mouse model of genetic GSH deficiency...
  10. Molecular Basis of BMP-15 Function
    Shunichi Shimasaki; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Bone Morphogenetic Protein-15 (BMP-15) is a critical growth factor that controls ovarian follicle growth and development, leading to the normal ovulation, thus, female fertility...
  11. LIM Homeodomain Regulated Genetic Pathways in Oogenesis and Ovarian Failure
    Aleksandar Rajkovic; Fiscal Year: 2010
    ..Early stages of ovarian follicle formation, beginning with the breakdown of germ cell cysts, formation of primordial follicles and transition ..
  12. GPR30 Mediated-Estrogen Action on Ovarian Physiology and Ovarian Cancer
    Cheng Wang; Fiscal Year: 2011
    ..that GPR30 is expressed in the hamster ovary and functions as a membrane estrogen receptor (mER) to regulate ovarian follicle formation and development...
  13. Bisphenol A and Ovotoxicity
    Jodi A Flaws; Fiscal Year: 2013
    ..The NCTR/FDA design can easily be expanded to measure the effects of BPA on ovarian follicle growth, atresia, follicle numbers, E2 levels, infertility, and premature ovarian failure...
  14. The Role Of CCL20 In Ovulation: A Novel Mediator Of Ovarian Leukocyte Recruitment
    Thomas E Curry; Fiscal Year: 2013
    ..by applicant): The preovulatory LH surge sets in motion a chain of events that culminate in breakdown of the ovarian follicle wall and release of the egg in a process known as ovulation...
  15. Epigenetic Regulation of Premature Ovarian Senescence by TAF4b
    Kathryn J Grive; Fiscal Year: 2013
    ..aging, or primary ovarian insufficiency, affects 1% of women under the age of 40, and can be induced by ovarian follicle disruption or depletion...
  16. ANALYSIS OF REPRODUCTIVE FUNCTION USING TRANSGENIC MICE
    Martin M Matzuk; Fiscal Year: 2010
    ..can substitute for the oocyte to regulate genes which are spatiotemporally expressed in the preovulatory ovarian follicle. Thus, GDF-9 is the first oocyte-secreted growth factor identified which plays multifunctional roles in the ..
  17. Function of Atg6 and autophagy in growth control
    Eric H Baehrecke; Fiscal Year: 2013
    ..Significantly, Atg6 mutant clones of eye and ovarian follicle epithelial cells possess a growth advantage over wild- type cell neighbors that is not shared by cells with ..
  18. Role of the BMP co-receptor Dragon (RGMb) in ovarian follicle development
    Herbert Y Lin; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Ovarian follicle development requires bidirectional communication between oocytes and surrounding granulosa cells...
  19. Hormonal Signals that Regulate Ovarian Diffrentiation
    Kelly E Mayo; Fiscal Year: 2013
    ..novel approaches to investigate roles for Notch signaling, activin action and estrogen regulation leading to ovarian follicle formation...
  20. Transcriptional Regulation of Early Folliculogenesis
    Aleksandar Rajkovic; Fiscal Year: 2013
    ..Early stages of ovarian follicle formation, beginning with the breakdown of germ cell cysts, formation of primordial follicles and transition ..
  21. Mechanisms of phthalate-induced ovarian follicle toxicity
    ZELIEANN RIVERA CRAIG; Fiscal Year: 2013
    ..Craig will investigate the mechanisms by which phthalates, a group of endocrine disrupting chemicals, cause ovarian follicle toxicity...
  22. Regulation of Drosophila Epithelial Polarity
    David Bilder; Fiscal Year: 2011
    ..of the Drosophila egg is a simple but little-studied process that requires PCP morphogenesis in the ovarian follicle cell epithelium...
  23. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility. ..
  24. The MMP system in human ovulation: localization, regulation, and function
    Thomas E Curry; Fiscal Year: 2013
    ..on a family of proteolytic enzymes, known as metalloproteinases, that we believe breakdown the wall of the ovarian follicle to allow the egg to be released...
  25. Mechanisms of phthalate-induced ovarian follicle toxicity
    ZELIEANN RIVERA CRAIG; Fiscal Year: 2013
    ..Craig will investigate the mechanisms by which phthalates, a group of endocrine disrupting chemicals, cause ovarian follicle toxicity...
  26. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..We will secondarily monitor endometrial thickness and ovarian follicle formation by ultrasound, endometrial histology by biopsy, ovarian steroid production by monthly serum and ..
  27. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    ..the biochemical structure and regulation of SIP and will provide valuable tools for future studies on the role of SIP in the development and function of ovarian follicle and corpus luteum during female reproductive cycle.
  28. Transcriptional control of FSH expression
    Daniel Bernard; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): The pituitary gland stimulates cycles of ovarian follicle maturation through its production and subsequent release of follicle-stimulating hormone (FSH)...
  29. REGULATION OF FOLLITROPIN ACTIONS
    Mario Ascoli; Fiscal Year: 2009
    ..FSH) are two anterior pituitary hormones that play key roles in the growth and development of the ovarian follicle. The LH and FSH receptors (LHR and FSHR, respectively) are both expressed in granulosa cells but in spite of ..
  30. Oxidative Stress and Oocyte Development
    CATHERINE COMBELLES; Fiscal Year: 2007
    ..we will investigate the oxidative stress systems that prevail in all of all the compartments making up the ovarian follicle. We will then be able to better define the milieu within which an oocyte acquires its normal ability to ..
  31. Activin signaling mechanisms in pituitary cells
    Daniel Bernard; Fiscal Year: 2005
    ..Disruption or deletion of the FSH receptor gene or the beta subunit of the FSH (FSH beta) protein arrest ovarian follicle maturation at the pre-antral stage, thereby preventing ovulation...
  32. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..These studies will likely demonstrate that the mid cycle gonadotropin surge initiates PG synthesis by primate ovarian follicle through the induction of specific enzymes and support the hypothesis that PGs act locally to trigger specific ..
  33. MESENCHYMAL/EPITHELIAL CELL INTERACTIONS IN THE OVARY
    Michael Skinner; Fiscal Year: 2000
    The proposed research is directed toward developing a better understanding of the mechanisms that control ovarian follicle development and growth, in particular the manner by which hormones and locally- produced ovarian substances ..
  34. OVARIAN LDL RECEPTOR AND STAR GENE REGULATION
    HOLLY LAVOIE; Fiscal Year: 2003
    ..Years 2-5: Parallel studies with dated ovarian follicle nuclear proteins will help identify which factors are regulated and expressed concurrently with StAR and LDL ..
  35. Function of the Drosophila Myb Proto-Oncogene
    Joseph Lipsick; Fiscal Year: 2005
    ..found that Dm-Myb is required in ovarian nurse cells for proper endocycles that normally lack mitoses and in ovarian follicle cells for chorion gene amplification...
  36. Oxidative stress drives ovarian aging: modification by genetics and environment
    Ulrike Luderer; Fiscal Year: 2009
    Fertility declines with age in women, due in large part to decreased ovarian follicle numbers...
  37. Inhibins and Environmental Estrogens in Ovarian Disease
    Louis Guillette; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Development of the ovarian follicle is a complex process integral to female fertility...
  38. ROLE OF THE FAS ANTIGEN IN OVARIAN CELL APOPTOSIS
    SUSAN QUIRK; Fiscal Year: 2004
    ..abstract) The proposed experiments will test the hypothesis that alterations in the cell cycle during ovarian follicle development modulate the susceptibility of follicle cells to undergo apoptosis...
  39. GONADAL AND ENDOMETRIAL FUNCTION IN HUMAN REPRODUCTION
    Renee Reijo Pera; Fiscal Year: 2007
    ..Projects I and III (Hsueh and Conti) interact, as they focus on early ovarian follicle development and on the role of mechanisms governing meiosis in the female gonad, respectively...
  40. Ovarian Aspects of Caloric Restriction
    MARY ZELINSKI WOOTEN; Fiscal Year: 2004
    ..spontaneous menstrual cycles and the peri-menopausal period; 2) the responsiveness of somatic cells of the ovarian follicle, i.e...
  41. GENOMIC SCALE CLONING OF NUCLEAR DNA BINDING PROTEINS
    Peter Tolias; Fiscal Year: 1999
    ..Since CF2-II is expressed in the nuclei of ovarian follicle cells, the investigators will determine whether any of the amplified pools of DNA contain known CF2-binding ..
  42. Activin Target Genes in the Ovary: Regulation of Ovarian Follicle Development
    JINGJING KIPP; Fiscal Year: 2009
    ..steroid hormone estrogen, both of which have been demonstrated to play an intra-ovarian role in regulating ovarian follicle development. I have revealed a linkage between activin and estrogen signaling pathways in the ovary...
  43. GONADOTROPIN ACTION IN FOLLICLES AND CORPORA LUTEA
    MARY HUNZICKER DUNN; Fiscal Year: 1990
    ..stimulating hormone (FSH) and steroid hormones like estrogen; their physiological significance in the ovarian follicle and corpus luteum...
  44. NEUROENDOCRINOLOGY OF REPRODUCTION AND GROWTH
    Nicholas Ling; Fiscal Year: 1992
    ..the current renewal application contains projects aimed at elucidating the complex mechanisms regulating ovarian follicle growth and differentiation...
  45. THE EFFECTS OF DEXAMETHASONE ON FOLLICULAR DEVELOPMENT
    LAURA ROCKWELL; Fiscal Year: 2001
    ..Three studies will be conducted. The first will evaluate the number of healthy versus atretic ovarian follicle, at 3 stages of follicular growth, at 6 time points following either gonadotropin priming (controls) or ..
  46. The Role of the Hedgehog Signaling Pathway in Ovarian Follicle Development
    SUSAN QUIRK; Fiscal Year: 2009
    ..Hh signaling is required for ovarian follicle development in Drosophila but its role in the mammalian ovary is not known...
  47. AGING OF THE NORMAL HUMAN OVARY FROM BIRTH TO MENOPAUSE
    Nancy Klein; Fiscal Year: 2003
    ..Ultimate depletion coincides with the onset of menopause therefore, the rate of ovarian follicle depletion is the final determinant of the duration of the reproductive life span...
  48. Drosophila DNA Replication Origins
    John Tower; Fiscal Year: 2005
    ..being utilized is the developmentally regulated amplification of the chorion gene clusters in Drosophila ovarian follicle cells. The control of DNA replication is particularly relevant to the study of human cancers...
  49. BIOLOGICAL BASIS OF THE PERIMENOPAUSE
    DAVID SEIFER; Fiscal Year: 2002
    ..The working hypothesis is that reproductive aging results in an ovarian follicle containing somatic cells (granulosa cells) and germ cells (oocytes) which are of compromised quality (..
  50. In Vivo Trapping of Genes Involved in Ovulation
    Lane Christenson; Fiscal Year: 2005
    Ovulation is a precisely timed event in which a mature oocyte is released from an ovarian follicle. The ovulatory process is associated with the transcriptional regulation of numerous genes, including the upregulation of CCAAT/enhancer ..
  51. EARLY ASPECTS OF FOLLICULAR DEVELOPMENT
    ANNE HIRSHFIELD; Fiscal Year: 1993
    ..goal of this research is to understand the mechanisms that direct the assembly and early growth of the ovarian follicle in rats...
  52. Regulation of Ovarian Follicle Activation
    DIEGO CASTRILLON; Fiscal Year: 2009
    ..These studies could also lead directly to prognostic tests to identify women predisposed to develop premature ovarian failure. ..
  53. PHYSIOLOGICAL MEDIATORS OF GRANULOSA CELL APOPTOSIS
    Alan Johnson; Fiscal Year: 2000
    It is now widely accepted that ovarian follicle atresia is initiated within the granulosa cell layer via the process of apoptosis. However, the identity of intracellular pathways leading to granulosa cell death remain largely unknown...
  54. NORMAL AND MUTANT CHORION GENES OF DROSOPHILA
    Allan Spradling; Fiscal Year: 1992
    ..research analyzes molecular mechanisms regulating chorion (eggshell) gene expression in time and space within ovarian follicle cells during Drosophila oogenesis...
  55. Regulation of meiotic arrest by a Gs-linked receptor
    LAURINDA JAFFE; Fiscal Year: 2007
    The mammalian ovarian follicle presents a remarkable example of how cells communicate to regulate the cell cycle within a complex tissue...
  56. Role of EGF-like growth factors in LH-induced ovulation
    Minnie Hsieh; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): In 'mammals, the LH surge produce dramatic changes on the ovarian follicle that culminate with ovulation of a fertilizable egg...
  57. REGULATION OF OVARIAN FOLLICLE GROWTH BY FSH
    Thomas Mills; Fiscal Year: 1980
    ..Clearly, since the growth of ovarian follicles is an integral part of the mammalian reproductive process, interruption or alteration in follicle growth whould be of potential value as a contraceptive...
  58. SYMPOSIUM--'NEW DIRECTIONS IN PRIMATE REPRODUCTION'
    REINHOLD HUTZ; Fiscal Year: 1992
    ..The general areas to be addressed will be: (1) regulation of ovarian follicle development and follicular imaging; (2) primate in-vitro fertilization; and (3) embryonic development and ..
  59. Signaling Cascades that Mediates FSH Action in the Ovary
    CHAD WAYNE; Fiscal Year: 2005
    Growth of the ovarian follicle is a developmental program dependent on stage-specific gene expression that is responsible for controlling granulosa cell fate, proliferation and differentiation...
  60. OVARIAN GROWTH FACTORS
    James Hammond; Fiscal Year: 2003
    ..enhances granulosa cell replication, survival and differentiation at various times in the lifespan of the ovarian follicle. These studies will develop a detailed picture of the signal transduction pathways which mediate these ..
  61. Cellular Mechanisms Controlling Dog Oocyte Maturation
    Nucharin Songsasen; Fiscal Year: 2008
    ....
  62. Molecular Mechanisms of Ovarian Follicular Activation
    JOANNE FORTUNE; Fiscal Year: 2004
    ..Elucidation of these fundamental mechanisms has practical implications for the development of new contraceptive technologies and alleviation of infertility. ..
  63. SELECTION OF THE DOMINANT FOLLICLE AND THE IGF SYSTEM
    JOANNE FORTUNE; Fiscal Year: 2003
    ..abstract_text> ..
  64. Regulation of Prostaglandins in Periovulatory Follicles
    JOANNE FORTUNE; Fiscal Year: 2005
    ..Together these experiments will provide new knowledge about the regulation of, and relationship between, these two essential mediators of ovulation and their receptors. ..
  65. RCT of a Novel Oral Contraceptive Initiation Method
    Carolyn Westhoff; Fiscal Year: 2004
    ..We will also assess dual method use for STD prevention in the study to adoption of and adherence to oral contraceptives. We will also assess dual method use for STD prevention in the study population. ..
  66. Role of integrins and activin in granulosa cell growth
    Kutluk Oktay; Fiscal Year: 2007
    ..with an internationally recognized reproductive biologist, the candidate began studying integrin signaling in ovarian follicle growth in collaboration with the proposed mentor of this project...
  67. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2008
    ..Specific Aim II: Determine the function of AREG target genes that are uniquely expressed at high levels in ovulated COCs (compared to granulosa cells) and that impact ovulation. ..