ovary

Summary

Summary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.

Top Publications

  1. ncbi Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    Julius Brennecke
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA
    Cell 128:1089-103. 2007
  2. pmc Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary
    Colin D Malone
    Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
    Cell 137:522-35. 2009
  3. ncbi Cancer of the ovary
    Stephen A Cannistra
    Program of Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 351:2519-29. 2004
  4. pmc DMRT1 prevents female reprogramming in the postnatal mammalian testis
    Clinton K Matson
    Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 476:101-4. 2011
  5. ncbi Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation
    N Henriette Uhlenhaut
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Cell 139:1130-42. 2009
  6. ncbi The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
  7. pmc Retinoic acid regulates sex-specific timing of meiotic initiation in mice
    Jana Koubova
    Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:2474-9. 2006
  8. pmc An epigenetic role for maternally inherited piRNAs in transposon silencing
    Julius Brennecke
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory CSHL, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 322:1387-92. 2008
  9. ncbi ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria
    A P Ferraretti
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 26:1616-24. 2011
  10. ncbi Retinoid signaling determines germ cell fate in mice
    Josephine Bowles
    Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Science 312:596-600. 2006

Detail Information

Publications372 found, 100 shown here

  1. ncbi Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    Julius Brennecke
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA
    Cell 128:1089-103. 2007
    ..Thus, sense piRNAs, formed following cleavage of transposon mRNAs may enhance production of antisense piRNAs, complementary to active elements, by directing cleavage of transcripts from master control loci...
  2. pmc Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary
    Colin D Malone
    Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
    Cell 137:522-35. 2009
    ....
  3. ncbi Cancer of the ovary
    Stephen A Cannistra
    Program of Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 351:2519-29. 2004
  4. pmc DMRT1 prevents female reprogramming in the postnatal mammalian testis
    Clinton K Matson
    Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 476:101-4. 2011
    ..Reprogramming due to loss of Dmrt1 also may help explain the aetiology of human syndromes linked to DMRT1, including disorders of sexual differentiation and testicular cancer...
  5. ncbi Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation
    N Henriette Uhlenhaut
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Cell 139:1130-42. 2009
    ..factor, the forkhead transcriptional regulator FOXL2, is required to prevent transdifferentiation of an adult ovary to a testis...
  6. ncbi The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
    ..The W (female) chromosome may carry a dominant-acting ovary determinant...
  7. pmc Retinoic acid regulates sex-specific timing of meiotic initiation in mice
    Jana Koubova
    Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:2474-9. 2006
    ..Because RA signaling regulates Stra8 expression in both embryonic ovaries and adult testes, this portion of the meiotic initiation pathway may be identical in both sexes...
  8. pmc An epigenetic role for maternally inherited piRNAs in transposon silencing
    Julius Brennecke
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory CSHL, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 322:1387-92. 2008
    ..This indicates that maternally deposited piRNAs are important for mounting an effective silencing response and that a lack of maternal piRNA inheritance underlies hybrid dysgenesis...
  9. ncbi ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria
    A P Ferraretti
    S I S Me R Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy
    Hum Reprod 26:1616-24. 2011
    ..Finally, by reducing bias caused by spurious POR definitions, it will be possible to compare results and to draw reliable conclusions...
  10. ncbi Retinoid signaling determines germ cell fate in mice
    Josephine Bowles
    Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Science 312:596-600. 2006
    ..We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and initiate oogenesis...
  11. ncbi The mouse Spo11 gene is required for meiotic chromosome synapsis
    P J Romanienko
    Genetics and Biochemistry Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 20892, Bethesda, MD, USA
    Mol Cell 6:975-87. 2000
    ..We speculate that there is an additional role for Spo11, after it generates DSBs, in synapsis...
  12. ncbi Identification of miRNAs associated with the follicular-luteal transition in the ruminant ovary
    D McBride
    Division of Developmental Biology, The Roslin Institute and R D SVS, The University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Reproduction 144:221-33. 2012
    ..Our data identify a subset of miRNAs that are potentially important regulators of the follicular-luteal transition...
  13. pmc Paucity of genes on the Drosophila X chromosome showing male-biased expression
    Michael Parisi
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 8028, USA
    Science 299:697-700. 2003
    ..These data indicate that the X chromosome is a disfavored location for genes selectively expressed in males...
  14. pmc The carnegie protein trap library: a versatile tool for Drosophila developmental studies
    Michael Buszczak
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    Genetics 175:1505-31. 2007
    ..downstream of the enhanced green fluorescent protein (EGFP) exon, and analyzing expression patterns in the ovary and salivary gland, we found that 600-900 different genes are trapped in our collection...
  15. ncbi A candidate precursor to serous carcinoma that originates in the distal fallopian tube
    Y Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 211:26-35. 2007
    ....
  16. ncbi Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells
    C K Leonard
    Department of Medicinal Chemistry, Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 265:10373-82. 1990
    ..envelope glycoprotein (rgp120) of human immunodeficiency virus type 1 produced by expression in Chinese hamster ovary cells...
  17. pmc Repertoire of porcine microRNAs in adult ovary and testis by deep sequencing
    Mingzhou Li
    Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, Sichuan, China
    Int J Biol Sci 7:1045-55. 2011
    ..Identification and preliminary characterization of gonad-specific miRNAs would be a prerequisite for a thorough understanding of the role that miRNA-mediated posttranscriptional gene regulation plays in mammalian reproduction...
  18. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
    ..Each ovariole in the Drosophila ovary contains two germline stem cells surrounded by a group of differentiated somatic cells that express hedgehog and ..
  19. pmc Novel signaling mechanisms in the ovary during oocyte maturation and ovulation
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, United States
    Mol Cell Endocrinol 356:65-73. 2012
    ..This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation...
  20. pmc A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis
    Shin Yoshimoto
    Department of Bioscience, School of Science, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Proc Natl Acad Sci U S A 105:2469-74. 2008
    ..tadpoles showed ovarian cavities and primary oocytes with both drivers, suggesting that DM-W is crucial for primary ovary formation. Taken together, these results suggest that DM-W is a likely sex (ovary)-determining gene in X. laevis.
  21. pmc Detection, characterization, and spontaneous differentiation in vitro of very small embryonic-like putative stem cells in adult mammalian ovary
    Seema Parte
    Department of Stem Cell Biology, National Institute for Research in Reproductive Health, Mumbai, India
    Stem Cells Dev 20:1451-64. 2011
    ..Research at the single-cell level, including complete gene expression profiling, is required to further confirm whether postnatal oogenesis is a conserved phenomenon in adult mammals...
  22. pmc Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
    Yvonne A R White
    Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 18:413-21. 2012
    ..Thus, ovaries of reproductive-age women, similar to adult mice, possess rare mitotically active germ cells that can be propagated in vitro as well as generate oocytes in vitro and in vivo...
  23. pmc Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function
    Aritro Sen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 24:1393-403. 2010
    ..These GC-specific ARs appear to promote preantral follicle growth and prevent follicular atresia; thus they are essential for normal follicular development and fertility...
  24. ncbi Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes
    Irma Virant-Klun
    Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Differentiation 76:843-56. 2008
    There have been some proposals that stem cells exist in the ovarian surface epithelium (OSE) of the adult human ovary; however, no direct evidence of such cells has been given until now...
  25. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    The functions of estrogen receptors (ERs) in mouse ovary and genital tracts were investigated by generating null mutants for ERalpha (ERalphaKO), ERbeta (ERbetaKO) and both ERs (ERalphabetaKO)...
  26. ncbi Male-to-female sex reversal in mice lacking fibroblast growth factor 9
    J S Colvin
    Department of Molecular Biology and, Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 104:875-89. 2001
    ..While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species...
  27. ncbi Production of offspring from a germline stem cell line derived from neonatal ovaries
    Kang Zou
    School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Nat Cell Biol 11:631-6. 2009
    ..These findings contribute to basic research into oogenesis and stem cell self-renewal and open up new possibilities for use of FGSCs in biotechnology and medicine...
  28. ncbi Ovarian aging: mechanisms and clinical consequences
    F J Broekmans
    Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, The Netherlands
    Endocr Rev 30:465-93. 2009
    ..Improved knowledge of the ovarian ageing mechanisms may ultimately provide tools for prediction of menopause and manipulation of the early steps of folliculogenesis for the purpose of contraception and fertility lifespan extension...
  29. ncbi The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
    L Crisponi
    Istituto di Ricerca sulle Talassemie ed Anemie Mediterranee CNR, and Dipartimento di Scienze Biomediche e Biotecnologie, Ospedale Regionale per le Microcitemie, Universita degli Studi di Cagliari, Cagliari, Italy
    Nat Genet 27:159-66. 2001
    ..expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles; in adult humans, it appears predominantly in the ovary. FOXL2 represents a candidate gene for the polled/intersex syndrome XX sex-reversal goat.
  30. ncbi Anti-Müllerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study
    Mark F H Brougham
    Department of Pediatric Hematology and Oncology, Royal Hospital for Sick Children, 17 Millerfield Place, Edinburgh EH9 1LF, United Kingdom
    J Clin Endocrinol Metab 97:2059-67. 2012
    ..Assessment of ovarian damage in prepubertal girls is not currently possible, but Anti-Müllerian Hormone (AMH) is a useful marker of ovarian reserve in adults...
  31. ncbi How do chemotherapeutic agents damage the ovary?
    S Morgan
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Hum Reprod Update 18:525-35. 2012
    ..In this review we examine the current evidence for the direct action of chemotherapeutic agents on the ovary and discuss possible molecular pathways through which follicle loss may occur.
  32. ncbi A niche maintaining germ line stem cells in the Drosophila ovary
    T Xie
    Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Science 290:328-30. 2000
    ..The individual ovarioles of the Drosophila ovary each contain about two germ line stem cells that maintain oocyte production...
  33. pmc Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in Holstein cattle
    Jinming Huang
    Laboratory of Molecular Breeding, Center of Dairy Cattle Research, Shandong Academy of Agricultural Sciences, China
    Int J Biol Sci 7:1016-26. 2011
    ..In the present study, we identified novel and differentially expressed miRNAs in the testis and ovary in Holstein cattle by combining the Solexa sequencing with bioinformatics...
  34. ncbi Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    J Cell Physiol 213:581-8. 2007
    ..Finally, emphasis is placed on the clinical implications of EMT and potential therapeutic opportunities that may arise from these observations have been proposed...
  35. ncbi Functional analysis of Sox8 and Sox9 during sex determination in the mouse
    Marie Christine Chaboissier
    INSERM U470, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
    Development 131:1891-901. 2004
    Sex determination in mammals directs an initially bipotential gonad to differentiate into either a testis or an ovary. This decision is triggered by the expression of the sex-determining gene Sry, which leads to the activation of male-..
  36. ncbi The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance
    Dirk Schmidt
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:933-42. 2004
    ..Here, we show that the murine Foxl2 gene is essential for granulosa cell differentiation and ovary maintenance...
  37. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..Future experiments are required to determine the role of ERbeta in bone and cardiovascular homeostasis...
  38. ncbi Parthenogenetic embryo-like structures in the human ovarian surface epithelium cell culture in postmenopausal women with no naturally present follicles and oocytes
    Irma Virant-Klun
    Department of Obstetrics and Gynecology, University Medical Centre, Ljubljana, Slovenia
    Stem Cells Dev 18:137-49. 2009
    Little is known about parthenogenesis in the human ovary. What is known is related to patients with teratoma in their medical history...
  39. ncbi Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary
    Lourdes López-Onieva
    Centro Andaluz de Biología del Desarrollo CABD Pablo de Olavide, Carretera de Utrera Km 1, 41013 Sevilla, Spain
    Development 135:533-40. 2008
    ..Our results provide strong evidence for a model in which Jak/Stat signalling in somatic support cells regulates dpp transcription to define niche size and to maintain the adjacent germline stem cells in an undifferentiated state...
  40. ncbi Nanos maintains germline stem cell self-renewal by preventing differentiation
    Zhong Wang
    Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA
    Science 303:2016-9. 2004
    ..Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs...
  41. ncbi Cloning and analysis of fetal ovary microRNAs in cattle
    Swamy K Tripurani
    Laboratory of Animal Biotechnology and Genomics, Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV 26506 6108, United States
    Anim Reprod Sci 120:16-22. 2010
    ..To identify miRNAs in bovine oocytes/ovaries, a bovine fetal ovary miRNA library was constructed...
  42. pmc MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    Hyo Won Ahn
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Hum Reprod 16:463-71. 2010
    ..In order to identify a full transcriptome set of small RNAs expressed in the newborn (NB) ovary, we extracted small RNA fraction from mouse NB ovary tissues and subjected it to massive parallel sequencing using ..
  43. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness...
  44. ncbi A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
    H Lin
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 124:2463-76. 1997
    ..We have also identified a second and novel gene, piwi, whose mutations abolish germline stem cell division...
  45. pmc The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
    Norbert Gleicher
    Center for Human Reproduction, New York, New York, USA
    Reprod Biol Endocrinol 9:116. 2011
    ..Effects of androgens on follicle maturation have been controversial for some time. Here, we review the potential of their applications in improving human ovulation induction, based on human and animal data, reported in the literature...
  46. ncbi The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
    Ricardo Azziz
    Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Fertil Steril 91:456-88. 2009
    To review all available data and recommend a definition for polycystic ovary syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to guide clinical diagnosis and future research.
  47. pmc A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway
    Benjamin Czech
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Cell 50:749-61. 2013
    ..Our data uncover a previously unanticipated set of factors preferentially required for repression of different transposon types...
  48. ncbi Anti-Müllerian hormone: a new marker for ovarian function
    Jenny A Visser
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 131:1-9. 2006
    ..In the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growing ..
  49. pmc Three-dimensional ovarian organ culture as a tool to study normal ovarian surface epithelial wound repair
    Kevin S Jackson
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 150:3921-6. 2009
    Ovarian cancers are primarily derived from a single layer of epithelial cells surrounding the ovary, the ovarian surface epithelium (OSE)...
  50. pmc Aromatase expression in the ovary: hormonal and molecular regulation
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, 333 Cedar Street, PO 208063, New Haven, CT 06520, USA
    Steroids 73:473-87. 2008
    ..Here, the molecular and cellular mechanisms controlling the expression of the aromatase gene in granulosa and luteal cells are discussed...
  51. pmc Human ovarian reserve from conception to the menopause
    W Hamish B Wallace
    Department of Reproductive and Developmental Sciences, Division of Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e8772. 2010
    The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years...
  52. ncbi Anti-müllerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries
    Sharron A Stubbs
    Institute of Reproductive and Developmental Biology, Wolfson and Weston Research Centre for Family Health, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 90:5536-43. 2005
    Polycystic ovary syndrome, the most common cause of anovulatory infertility, is characterized by disordered folliculogenesis, notably increased progression from the primordial to the primary stages...
  53. ncbi Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish
    Yann Guiguen
    INRA, UR1037 SCRIBE, IFR140, Ouest genopole, F 35000 Rennes, France
    Gen Comp Endocrinol 165:352-66. 2010
    ....
  54. ncbi FGF9 suppresses meiosis and promotes male germ cell fate in mice
    Josephine Bowles
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Dev Cell 19:440-9. 2010
    ....
  55. pmc Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary
    Lucy X Morris
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Development 138:2207-15. 2011
    ..Additionally, escort cells are not replenished by the regular division of escort stem cells as previously suggested. Rather, escort cells remain quiescent and divide only to maintain a constant germ cell:escort cell ratio...
  56. pmc MicroRNA-196a regulates bovine newborn ovary homeobox gene (NOBOX) expression during early embryogenesis
    Swamy K Tripurani
    Laboratory of Animal Biotechnology and Genomics, Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV 26506, USA
    BMC Dev Biol 11:25. 2011
    ..Newborn ovary homeobox gene (NOBOX) is a transcription factor that is preferentially expressed in oocytes and essential for ..
  57. pmc Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization
    Emily S Jungheim
    Department of Obstetrics and Gynecology, Washington University, St Louis, Missouri 63108, USA
    Fertil Steril 95:1970-4. 2011
    ..To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology...
  58. pmc Chicken pleiotrophin: regulation of tissue specific expression by estrogen in the oviduct and distinct expression pattern in the ovarian carcinomas
    Jin Young Lee
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    PLoS ONE 7:e34215. 2012
    ....
  59. pmc LIN28 is selectively expressed by primordial and pre-meiotic germ cells in the human fetal ovary
    Andrew J Childs
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    Stem Cells Dev 21:2343-9. 2012
    ..We have therefore examined the expression of LIN28 during normal germ cell development in the human fetal ovary, from the PGC stage, through meiosis to the initiation of follicle formation...
  60. ncbi Growth differentiation factor-9 is required during early ovarian folliculogenesis
    J Dong
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 383:531-5. 1996
    ..Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised. Thus, GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo...
  61. ncbi Nutritional control of reproductive status in honeybees via DNA methylation
    R Kucharski
    Molecular Genetics and Evolution, ARC Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, Canberra ACT 0200, Australia
    Science 319:1827-30. 2008
    ....
  62. ncbi Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve
    I A J van Rooij
    Department of Reproductive Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Hum Reprod 17:3065-71. 2002
    ..Therefore, we studied the relationship between AMH levels and ovarian response during ovarian stimulation for IVF...
  63. ncbi Ovary cryopreservation and transplantation for fertility preservation
    S J Silber
    Infertility Center of St Louis, St Luke s Hospital, St Louis, MO 63017, USA
    Mol Hum Reprod 18:59-67. 2012
    ..improve when a series of nine monozygotic (MZ) twin pairs discordant for premature ovarian failure (POF) underwent ovary transplantation at one center...
  64. ncbi How can female germline stem cells contribute to the physiological neo-oogenesis in mammals and why menopause occurs?
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Microsc Microanal 17:498-505. 2011
    ....
  65. ncbi Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary
    A L Durlinger
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, The Netherlands
    Endocrinology 140:5789-96. 1999
    ..In females, AMH is produced by the ovary, but only postnatally. The function of AMH in the ovary is, however, still unknown...
  66. pmc Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:2949-55. 2008
    ..The identification of beta-catenin as a key pro-ovarian and anti-testis signaling molecule will further our understanding of the mechanisms controlling sex determination and the molecular mechanisms that lead to sex-reversal...
  67. ncbi Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study
    Ahmed Badawy
    Department of Obstetrics and Gynecology, Mansura University, Mansoura, Egypt
    Fertil Steril 91:694-7. 2009
    ..To determine whether GnRHa administration before and during combination chemotherapy for breast cancer could preserve posttreatment ovarian function in young women or not...
  68. ncbi Toll-like receptor expression in normal ovary and ovarian tumors
    Mingfu Zhou
    Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267 0521, USA
    Cancer Immunol Immunother 58:1375-85. 2009
    ....
  69. ncbi Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 131:1353-64. 2004
    The Drosophila ovary is an attractive system to study how niches control stem cell self-renewal and differentiation. The niche for germline stem cells (GSCs) provides a Dpp/Bmp signal, which is essential for GSC maintenance...
  70. ncbi The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals
    Eva Decotto
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218, USA
    Dev Cell 9:501-10. 2005
    ..These observations reveal striking similarities in the stem cell niches of male and female gonads, and suggest that they are largely governed by common mechanisms...
  71. ncbi Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy--a technique in its infancy but already successful in fertility preservation
    Michael von Wolff
    Department of Gynecological Endocrinology and Reproductive Medicine, University of Bern, Women s Hospital, Inselspital, Effingerstrasse 102, Bern 3010, Switzerland
    Eur J Cancer 45:1547-53. 2009
    ..It emphasises that fertility preservation by the cryopreservation of ovarian tissue is a new but already a successful clinical option, which can be considered for selected cancer patients...
  72. ncbi Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve
    Norbert Gleicher
    The Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York 10021, USA
    Fertil Steril 94:2824-7. 2010
    ..04 ng/mL but significantly increased at AMH 0.41-1.05 ng/mL, resulting in similarly low live-birth rates at all AMH levels ≤1.05 ng/mL and significantly improved live-birth rates at AMH ≥1.06 ng/mL...
  73. ncbi The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue
    Erik Ernst
    Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark
    Hum Reprod 25:1280-1. 2010
    ..This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment...
  74. pmc The mammalian ovary from genesis to revelation
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Rev 30:624-712. 2009
    Two major functions of the mammalian ovary are the production of germ cells (oocytes), which allow continuation of the species, and the generation of bioactive molecules, primarily steroids (mainly estrogens and progestins) and peptide ..
  75. ncbi A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish
    Saskia Houwing
    Hubrecht Laboratory, Uppsalalaan 8, Utrecht, Netherlands
    Cell 129:69-82. 2007
    ..Here we show that zebrafish piRNAs are present in both ovary and testis...
  76. pmc Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons
    Sergey Shpiz
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
    Nucleic Acids Res 39:8703-11. 2011
    ..Therefore piRNA-mediated transcriptional mode of silencing is involved in the control of retrotransposon expression in the Drosophila germline...
  77. pmc Identification and characterization of miRNAs expressed in the bovine ovary
    Md Munir Hossain
    Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany
    BMC Genomics 10:443. 2009
    ..Here, we report the identification and characterization of miRNAs expressed in the bovine ovary through cloning, expression analysis and target prediction.
  78. ncbi Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
    Serge Nef
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Dev Biol 287:361-77. 2005
    ..These studies define the major characteristics of testicular and ovarian transcriptional programs and reveal the richness of signaling processes in differentiation of the bipotential gonads into testes and ovaries...
  79. pmc Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice
    Motoyuki Otsuka
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:1944-54. 2008
    ..luteum (CL) insufficiency and resulted, at least in part, from the impaired growth of new capillary vessels in the ovary. We found that the impaired CL angiogenesis in Dicer(d/d) mice was associated with a lack of miR17-5p and let7b, 2 ..
  80. ncbi Identification of germline stem cells in the ovary of the teleost medaka
    Shuhei Nakamura
    Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Science 328:1561-3. 2010
    ..Our results provide insight into the germline stem cell biology of medaka and provide a model system for studying vertebrate stem cell niches...
  81. ncbi Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births
    Jacques Donnez
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Department of Gynecology, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Ann Med 43:437-50. 2011
    ....
  82. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
    ....
  83. pmc Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling
    Robin E Harris
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Dev Cell 20:72-83. 2011
    ..Mathematical modeling elucidates bistability of cell fate in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat coupling extracellular Dpp regulation to intracellular interpretation...
  84. ncbi Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells
    M A Balboa
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093 0601, USA
    J Biol Chem 272:8576-80. 1997
    ..Also an iPLA2 from Chinese hamster ovary (CHO) cells has been purified, molecularly cloned, and expressed (Tang, J., Kriz, R., Wolfman, N., Shaffer, M...
  85. pmc Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
    Yuichi Niikura
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 1:971-8. 2009
    ..Thus, aged mouse ovaries possess a rare population of premeiotic germ cells that retain the capacity to form oocytes if exposed to a young host environment...
  86. pmc Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
    ..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development...
  87. ncbi Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos
    Yanfeng Lin
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 322:1685-7. 2008
    ..Within a brief developmental window, Dazl-expressing germ cells in both XX and XY embryos actively acquire the ability to interpret RA as a meiosis-inducing signal...
  88. ncbi Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary
    Alexandra L L Durlinger
    Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Endocrinology 143:1076-84. 2002
    ..We tested this hypothesis in a neonatal ovary culture system, in which ovaries from 2-d-old C57Bl/6J mice were cultured for 2 or 4 d in the absence or presence ..
  89. pmc A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors
    Dominik Handler
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Vienna, Austria
    EMBO J 30:3977-93. 2011
    ....
  90. ncbi MicroRNA (miRNA) cloning analysis reveals sex differences in miRNA expression profiles between adult mouse testis and ovary
    Takuya Mishima
    Departments of, Molecular Anatomy and Medicine Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
    Reproduction 136:811-22. 2008
    ..In this study, we performed small RNA library sequencing in adult mouse testis and ovary to reveal their characteristic organ- and gender-specific profiles and to elucidate the characteristics of the ..
  91. ncbi R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
    Kazuma Tomizuka
    Discovery Research Laboratories, Research Division, Kirin Pharma Co, Ltd, Takasaki shi, Gunma, 370 1295, Japan
    Hum Mol Genet 17:1278-91. 2008
    ....
  92. pmc Foxl2 functions in sex determination and histogenesis throughout mouse ovary development
    Jose Elias Garcia-Ortiz
    Laboratory of Genetics, NIA NIH IRP, Baltimore, MD, USA
    BMC Dev Biol 9:36. 2009
    ..g., Rspo1. Here we report expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit...
  93. ncbi Conserved role of nanos proteins in germ cell development
    Masayuki Tsuda
    Division of Mammalian Development, National Institute of Genetics, SOKENDAI, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Science 301:1239-41. 2003
    ..Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates...
  94. pmc Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Dev Dyn 230:210-5. 2004
    ..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary.
  95. ncbi Differentiation potential of germ line stem cells derived from the postnatal mouse ovary
    Jason Pacchiarotti
    PrimeGen Biotech, Irvine, CA 92618, USA
    Differentiation 79:159-70. 2010
    ..by using follicle kinetics studies and demonstration of mitotically active germ cells in the postnatal mouse ovary (Johnson et al., 2004; Kerr et al., 2006; Zhang et al., 2008)...
  96. pmc Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics
    Paul P Szotek
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:12469-73. 2008
    ..techniques, we identify a label-retaining cell population in the coelomic epithelium of the adult mouse ovary as candidate somatic stem/progenitor cells...
  97. ncbi Regulation of ovarian function: the role of anti-Müllerian hormone
    Alexandra L L Durlinger
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 124:601-9. 2002
    ..However, the patterns of expression of AMH and its type II receptor in the postnatal ovary indicate that AMH may play an important role in ovarian folliculogenesis...
  98. ncbi Apoptosis in the ovary: molecular mechanisms
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Assiut, Egypt
    Hum Reprod Update 11:162-77. 2005
    ..It also presents the existing literature and assesses the gaps in our knowledge...
  99. pmc Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation
    C S Raymond
    Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 14:2587-95. 2000
    ..As in the case of 9p deletions, Dmrt1 is dispensable for ovary development in the mouse. Thus, as in invertebrates, a DM domain gene regulates vertebrate male development.
  100. ncbi Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave
    Douglas B Menke
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Dev Biol 262:303-12. 2003
    ..Thus, sexual differentiation and meiotic entry of germ cells in embryonic XX gonads progress in an anterior-to-posterior pattern that may reflect local environmental cues that are present in the embryonic XX gonad...
  101. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
    Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity, and insulin resistance...

Research Grants82

  1. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  2. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..These changes may be due to direct ovarian effects on lipoprotein metabolism, and/or steroids secreted from the ovary having systemic effects on the liver or other organs...
  3. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..and apoptotic cell death will be assessed in Langendorff-perfused hearts following global I/R in adult and aged ovary-intact and gonadectomized female rats;respiration studies will be performed in isolated mitochondria...
  4. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even ..
  5. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..associated with aberrant ovarian steroid secretion are hypertension, diabetes, obesity, osteoporosis, polycystic ovary syndrome and neoplasms of the colon, breast, ovary, and uterus...
  6. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ..gene SRY initiates an incompletely understood network that directs the gonad to become a testis rather than an ovary. In nonmammalian vertebrates, other genes in the network determine sex, and in some species, environmental factors ..
  7. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..e. breast, prostate or ovary);and 4) develop 64Copper-labeled peptide counterparts for sensitive PET imaging...
  8. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..The CE-rich LDs in the adrenal and ovary serve as important sources of cholesterol substrate for steroid hormone production...
  9. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and testis, for which first-line therapy can potentially include platinating agents...
  10. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..We have shown that developmental exposure to MXC alters gene expression in the ovary, leading to inhibition of follicular maturation and the ovulation, which are associated with gene-specific [(e.g...
  11. Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy
    Bingliang Fang; Fiscal Year: 2013
    ..on NCI-60 cell lines showed that oncrasins are active against several cell lines derived from lung, colon, breast, ovary, and kidney cancers and oncrasin-60 lies outside the category of adequately studied classes of antitumor agents, ..
  12. Role of Sex Chromosome Complement in the CNS during Autoimmune Disease
    Sienmi Du; Fiscal Year: 2013
    ..This result in XX and XY- ovary-bearing females, where Y- denotes that the Sry gene was deleted and other Y genes remain...
  13. MECHANISM OF DRUG TRANSPORT IN LUNG CANCER CELLS
    Sanjay Awasthi; Fiscal Year: 2011
    ..conjugate (GS-E) transporter which is overexpressed in a number of types of cancers (lung, ovary, prostate, skin), but not in all types (breast, liver)...
  14. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..of EPO and/or its receptor (EPOR) genes are found in brain, endothelium, hematopoietic stem cells, breast, ovary, testes, and other tissues...
  15. Adult and Transgenerational Toxicity Due to Developmental TCDD Exposure
    Tracie R Baker; Fiscal Year: 2013
    ..The University of Wisconsin has numerous NIH-sponsored training programs, core facilities and funded researchers making it an ideal training environment for me to develop as an independent scientist. ..
  16. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..Since E2 is the primary and most potent estrogen produced by the human ovary, we propose to consider Q-E2 as a pro-drug for the treatment of perimenopausal symptoms, primarily hot flushes...
  17. Simultaneous Insulin and Leptin Signaling in POMC Neurons Promotes Fertility and
    LATRICE DOREEN FAULKNER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is the most frequent endocrine disorder seen in reproductive-aged women and is characterized by chronic anovulation, infertility, insulin resistance, and ..
  18. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..and also provide a foundation for improved prevention of cancer of the colon, prostate, breast, stomach and ovary, all of which are stimulated by beta-adrenergic signaling...
  19. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..researchers with expertise in neoplastic processes of the skin, head and neck, lung, colorectum, pancreas, breast, ovary and cervix, as well as technical expertise in, and resources for, surface- enhanced laser desorption/ionization ..
  20. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..We use genetic and biochemical approaches, live imaging and in vitro germ cell cultures to address how lipids and lipid modification provide migratory cues and how these signals are interpretated by the migrating germ cells. ..
  21. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is a common disorder affecting 7% of reproductive age women marked by elevated androgen levels, oligo-anovulation, and polycystic ovarian morphology...
  22. Transposons in Female Reproductive Health and Disease
    Zev Williams; Fiscal Year: 2013
    ..The purpose of this study is to determine how the oocyte suppresses transposons and the effect of transposons on female reproduction. ..
  23. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..This research project will fill the knowledge gap about the biology of revascularization of ovarian grafts, which limits the fraction of surviving follicles, and will test two strategies aimed at enhancing angiogenesis. ..
  24. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..new leads for contraception, as well as treatments for infertility and the pubertal disorders polycystic ovary syndrome, hypogonadism, precocious puberty, and delayed puberty, which possibly result from an abnormal increase ..
  25. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark S Shapiro; Fiscal Year: 2010
    ..expression system in which M-channels, receptors and signaling molecules are expressed in Chinese hamster ovary (CHO) cells, preparations of rat and mouse superior cervical ganglia (SCG) and nodose ganglia (NG) neurons, and a ..
  26. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    Revisions are noted in italics and underlined: Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age, is the most common endocrine abnormality, and increases risk for cardiovascular disease during the reproductive ..
  27. Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
    Kun Ming Chen; Fiscal Year: 2013
    ..Recent studies have shown that tobacco smoking is associated with cancer of the ovary. The mechanisms that can account for the role of tobacco smoking on this disease remain unknown...
  28. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility among women, and women with PCOS are at increased risk for pregnancy complications such as gestational diabetes and pre-eclampsia...
  29. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2012
    ..Pituitary-derived gonadotropic hormones in turn regulate the function of the ovary and testis...
  30. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..The same receptor is present in pituitary gonadotropes and the ovary and thus antagonists may also suppress gonadotropin hormone secretion and ovarian estrogen synthesis...
  31. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2013
    ..Findings resulting from this application are likely to contribute to a better understanding of the cues and cellular processes that guide germ cell migration and that physically distinguish germ cells from other cells in the body. ..
  32. Nuclear Lipids in Steroidogenesis
    Marion B Sewer; Fiscal Year: 2013
    ..This work will provide insight into multiple endocrine disorders, including adrenal hyperplasia, polycystic ovary syndrome, and Cushing's disease.
  33. EGF RECEPTOR MEDIATED SIGNALING IN DROSOPHILA
    GERTRUD M SCHUPBACH; Fiscal Year: 2013
    ..Our model system focuses on signaling between the female germline and its surrounding follicle cells in the ovary of Drosophila melanogaster...
  34. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..The actions of granulosa cells in the ovary are central to successful ovulation...
  35. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..discovery of nongenomic PGR membrane components (PGRMC1 and 2) adds another dimension to possible P actions in the ovary. Likewise, the PI's evidence that LH and P regulate expression of one estrogen receptor isoform (ERss) ..
  36. IMMUNOLOGY OF UNIQUE TUMOR SPECIFIC ANTIGENS
    Hans Schreiber; Fiscal Year: 2013
    ..A large percentage of common human cancers (e.g., colon, breast, lung, prostate, ovary and pancreas) have defects in O-linked glycosylation thereby generating tumor-specific epitopes on surface ..
  37. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    JENNIFER HERNANDEZ GIFFORD; Fiscal Year: 2010
    ..and hormonal regulation of several members of the WNT and Frizzled families have been reported in the adult rodent ovary and the downstream regulator of the WNT signaling pathway, [unreadable]-catenin, has been shown to play a role in ..
  38. Defining the role of proteostasis pathways in cancer drug resistance
    ERICA LYNN CAIN; Fiscal Year: 2013
    ..interaction has made PARPi an attractive drug therapy for BRCA2-deficient cancers of the breast, prostate, and ovary;however, PARPi resistance arises from the expression of BRCA2 reversion alleles encoding a mutated, but functional,..
  39. VCU Building Interdisciplinary Research Careers in Women's Health
    Jerome F Strauss; Fiscal Year: 2011
    ..to investigate the pathogenesis and develop preventive and therapeutic interventions for pre-eclampsia, polycystic ovary syndrome, perinatal depression, preterm birth, low birth weight, vaginal bacteriosis, breast and ovarian cancer, ..
  40. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2013
    ..These two systems provide a unique opportunity to study both genomic (fat body) and non-genomic (ovary) actions of JH in the same insect at the same time...
  41. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..Collectively, these findings support the hypothesis that LIF synthesis and signaling in the primate ovary is a critical regulator of events necessary for ovulation and formation of the corpus luteum (assessed in Aim 1);..
  42. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..radiation exposure, a major source of vitamin D (vit D), has been found for cancers of the breast, colon, rectum, ovary, prostate, stomach, and numerous other cancers...
  43. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    ..out using purified extracellular domain of the CD34 protein from mammalian cell expression system (Chinese Hamster Ovary cells) such that the structure and post-translational modifications are conserved...
  44. Phylogenomics and functional diversification of the Heterochromatin Protein 1 gen
    MIA TAUNA LEVINE; Fiscal Year: 2012
    ..genome are linked to cancer progression in at least one tissue type/cell line, including breast, brain, colon, and ovary, and in leukemia and papillary thyroid carcinoma...
  45. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..data suggest the overall hypothesis of this R21 application: that steroids produced by the fetal bovine ovary, particularly estradiol and progesterone, regulate both follicle formation and the competence of follicles to be ..
  46. Mouse model for eyelid disease: Congenital blepharophimosis
    Chia Yang Liu; Fiscal Year: 2013
    ..We will also delineate a molecular pathway that leads to the down-regulation of FoxL2 and subsequent malformation of the levator M[unreadable]ellersmooth muscle during embryonic eyelid development (Aim2). ..
  47. Insulin Clearance: Candidate and Positional Genetic Determinants
    MARK GOODARZI; Fiscal Year: 2012
    ..attention in the study of metabolic disorders (such as diabetes, obesity, the metabolic syndrome, and polycystic ovary syndrome) that predispose to cardiovascular disease, while insulin clearance has been largely overlooked...
  48. Regulation of tubulogenesis in the Drosophila ovary
    Celeste A Berg; Fiscal Year: 2012
    ..In the fly ovary, certain follicle cells that surround the oocyte reorganize from a curved sheet into a pair of elongated tubes...
  49. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Pathologies associated with the ovary carry a high morbidity and mortality, largely through difficulty in detection, but also from a lack of treatment ..
  50. Steroid regulation of glucose utilization during early pregnancy.
    ANTONINA I FROLOVA; Fiscal Year: 2010
    Women with polycystic ovary syndrome (PCOS), obesity, and insulin resistance experience increased rates of implantation failure, which contribute to the higher degree of poor pregnancy outcomes observed in these populations...
  51. Mammalian Mitochondrial One-Carbon Metabolism
    DEAN RAMSAY APPLING; Fiscal Year: 2010
    ..The experimental design includes isolation of human and rodent cDNAs and expression in Chinese hamster ovary cells to confirm localization to mitochondria...
  52. REGULATION OF OVARIAN FUNCTION BY GONADOTROPIN
    JAIRAM K M MENON; Fiscal Year: 2013
    ..The major focus of the proposed studies is to determine the mechanisms modulating LHR expression in the ovary. Since LHR expression shows fluctuations during the ovarian cycle in response to a constantly changing milieu of ..
  53. Stress: Potential Impact on an Animal Model of Endometriosis
    Caroline B Appleyard; Fiscal Year: 2012
    ..The results of these studies are also expected to identify possible interventions that will ultimately help women affected by this disease to live healthy and productive lives, in accordance with the mission of the NIH. ..
  54. Research Training Prog in Reproductive Biol & Med for Latin American Scientists
    John E Nestler; Fiscal Year: 2010
    ..led by presenters from VCU and Chile will cover research areas covered by training mentors, including polycystic ovary syndrome and insulin resistance, preterm birth, pre-eclampsia, fetal membrane rupture, cell signaling, gonorrhea ..
  55. Thermoscientific TSQ Vantage Mass Spectrometer
    Leland H Hartwell; Fiscal Year: 2010
    ..pathways and protein quality control;validate serum biomarkers in cancers of the breast, pancreas, prostate, ovary, and lung;and measure the serum half life of tumor "painting" reagents...
  56. GHSU/WSU Cooperative Reproductive Medicine Network
    Michael Peter Diamond; Fiscal Year: 2013
    ..period of support stems from recent secondary analysis of data from the RMN's Pregnancy in Polycystic Ovary Syndrome study, in which the applicants identified a novel outcome: the standard clinical practice of inducing a ..
  57. The Biodemographic Determinants of Life Span
    James R Carey; Fiscal Year: 2010
    ..aging in honey bees and directed by Robert Page (Arizona) will address questions concerned with how the honeybee ovary is involved in post emergence development, life history development, reproduction, and life span...
  58. Development of Superactive Analogs of FSH for Human Infertility
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..We have also achieved development of a stable Chinese Hamster Ovary (CHO) cell line producing high levels of the final TR4401 analog;optimization of large scale bioreactor production ..
  59. Effect of Insulin on Estrogen Receptor Alpha Activity in Human Endometrial Cells
    CLARE ANN FLANNERY; Fiscal Year: 2013
    ..Insulin resistance is an underlying pathology in obesity, the Polycystic Ovary Syndrome (PCOS), and type 2 diabetes mellitus (T2DM)...
  60. The Genetics of Polycystic Ovary Syndrom
    Corrine K Welt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women, yet its etiology is poorly understood...
  61. GENETIC CONTROL OF PROTEOGLYCAN METABOLISM
    Jeffrey D Esko; Fiscal Year: 2010
    ..and biochemical experiments to probe the biosyntheticpathways of heparan sulfate synthesis in Chinese hamster ovary (CHO) cells and mice. Specifically,we plan to execute the following studies: 1...
  62. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2013
    ..important role for these proteases, the action of MMPs during recrudescence and the process of how the quiescent ovary can resume cycling following weeks of atrophy is unknown...
  63. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
    ..An in vitro perfused ovary preparation will be used to isolate the ovary from systemic influences, regulate the contents of the perfusion ..
  64. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    ..LH, acting at the level of the ovary increases intracellular cAMP and thus initiates a cascade of intracellular events...
  65. Estrogenic activity of uranium in vitro and in vivo
    CHERYL DYER; Fiscal Year: 2007
    ..new data we propose the hypothesis that in utero U exposure permanently alters the programming of the developing ovary so that it produces more androgen that over a lifetime contributes to premature ovarian failure and metabolic ..
  66. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    ..hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary. However, locally produced growth factors, cytokines and other proteins and peptides modulate the actions of LH ..
  67. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..Most (about 70%) ovarian cancers are diagnosed when the cancer has spread outside the ovary, having disseminated to the peritoneal lining of the abdomen, and most (about 85%) are diagnosed in women post-..
  68. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2003
    The primary functional unit of the ovary is the follicle, a structure composed of a single germ cell (oocyte) surrounded by a somatic cell lineage, referred to as granulosa cells (GC), that is the source of estrogens produced by the ..
  69. ICE-FREE PRESERVATION OF OVARIES FOR LONG-TERM FECUNDITY
    Ying Song; Fiscal Year: 2004
    ..This research project is the first step towards establishment of an ovary bank for the processing, storage and distribution of the cryopreserved ovarian tissue for clinical use...
  70. Insulin signaling in theca cells from polycystic ovaries
    Denis Magoffin; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disease in women of reproductive age...
  71. A novel model of reproductive and metabolic features of polycystic ovary syndrome
    Romana A Nowak; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is one of the most common human reproductive endocrine disorders...
  72. REGULATORY MECHANISMS OF OVARIAN PROGESTERONE RECEPTORS
    Ok Kyong Park Sarge; Fiscal Year: 2000
    ..Dr Park-Sarge's research has focused on the regulatory mechanisms of the progesterone receptor gene in tahe ovary. The observation she made during her postdoctoral training period, that the ovary transiently expresses the ..
  73. Pregnancy Outcomes in Polycystic Ovary Syndrome
    Joan Lo; Fiscal Year: 2009
    Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among reproductive-age women, affecting ~5-10 percent of women in the general population...
  74. HORMONE ACTION IN THE OVARY: ROLE OF CALCIUM IONS
    Johannes Veldhuis; Fiscal Year: 1999
    ..theme of study focuses on the mechanisms by which Ca2+ pathways mediate gonadotropic hormone action in the ovary. To this end, we have utilized single-cell digital fluorescence videomicroscopy of ovarian (granulosa) cells to ..
  75. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    DESCRIPTION: (Adapted from the Investigator's Abstract) Polycystic ovary syndrome (PCOS), characterized by chronic anovulation, hyperandrogenism, and insulin resistance, is estimated to affect four percent to eight percent of all women...
  76. REGULATION OF CHOLESTEROL ESTERASE IN STEROIDOGENESIS
    FREDRIC KRAEMER; Fiscal Year: 1999
    The presence of substantial pools of cholesteryl esters in the adrenal cortex and ovary, and the recognition that this potential substrate enters the steroidogenic pathway as free cholesterol, signifies the important role of cholesterol ..
  77. Reversal of Infertility in Ovarian Failure
    Ayman Al Hendy; Fiscal Year: 2006
    ..In the presence of normal karyotype, ovarian failure is usually due to resistant ovary syndrome (ROS)...
  78. GnRH Gene Expression in the Ovary
    Helen Kim; Fiscal Year: 2009
    ..A more comprehensive understanding of the mechanisms regulating GnRH expression in the ovary may provide insights into its physiologic role...
  79. ROSIGLITAZONE IN POLYCYSTIC OVARY SYNDROME
    Nicholas Cataldo; Fiscal Year: 2002
    DESCRIPTION: (Adapted from applicant's description): Polycystic ovary syndrome (PCOS) is a disorder affecting about 5% of reproductive-age women characterized by anovulation and excess production of androgens by the ovary...
  80. Protein targets of ovarian and oocyte autoantibodies
    Judith Luborsky; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): There is compelling evidence for an autoimmune disease of the ovary. Ovarian autoimmunity may affect 1-2 million women in the US...
  81. ANGIOTENSIN II--AN INTRAOVARIAN REGULATORY PEPTIDE
    Ahsan Husain; Fiscal Year: 1992
    ..We have also demonstrated: 1) that Ang II causes an increase in the secretion of estradiol-17 beta from the rat ovary; and 2) that both Ang II and angiotensin I converting enzyme (ACE) are present in the rat ovary...
  82. Role of the BMP co-receptor Dragon (RGMb) in ovarian follicle development
    Herbert Y Lin; Fiscal Year: 2010
    ..is to determine the role of Dragon, a bone morphogenetic protein (BMP) co-receptor, in follicle development in the ovary. Follicle development requires communication between oocytes and granulosa cells...