vulva

Summary

Summary: The external genitalia of the female. It includes the CLITORIS, the labia, the vestibule, and its glands.

Top Publications

  1. pmc Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction
    Julie E Gleason
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Genes Dev 16:1281-90. 2002
  2. ncbi lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development
    Rashmi Deshpande
    Department of Molecular Genetics, The Ohio State University, 963 Biological Science Building, 484 W 12th Avenue, Columbus, OH 43210, USA
    Dev Biol 278:118-29. 2005
  3. pmc Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways
    Xiaoyue Wang
    Department for Evolutionary Biology, Max Planck Institut for Developmental Biology, Tubingen, Germany
    PLoS Biol 9:e1001110. 2011
  4. pmc Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network
    Erika Hoyos
    Center for Cell Dynamics, University of Washington, 620 University Road, Friday Harbor, WA 98250, USA
    Curr Biol 21:527-38. 2011
  5. ncbi EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans
    R D Burdine
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8005, USA
    Development 125:1083-93. 1998
  6. ncbi Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
    Duo Wang
    Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 436:593-7. 2005
  7. pmc RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans
    Olga Skorobogata
    Division of Endocrinology and Metabolism, Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    PLoS ONE 7:e36489. 2012
  8. ncbi MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction
    P B Tan
    Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
    Cell 93:569-80. 1998
  9. ncbi Robustness and flexibility in nematode vulva development
    Marie Anne Felix
    Institut de Biologie de l Ecole Normale Supérieure, CNRS Inserm ENS, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Trends Genet 28:185-95. 2012
  10. ncbi FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans
    David R Sherwood
    HHMI and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Cell 121:951-62. 2005

Detail Information

Publications303 found, 100 shown here

  1. pmc Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction
    Julie E Gleason
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Genes Dev 16:1281-90. 2002
    ..These data suggest that hyperactivation of Wnt signaling is sufficient to cause VPCs to adopt induced fates and that a canonical Wnt pathway may play an important role during C. elegans vulval induction...
  2. ncbi lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development
    Rashmi Deshpande
    Department of Molecular Genetics, The Ohio State University, 963 Biological Science Building, 484 W 12th Avenue, Columbus, OH 43210, USA
    Dev Biol 278:118-29. 2005
    The Caenorhabditis elegans vulva is comprised of highly similar anterior and posterior halves that are arranged in a mirror symmetric pattern...
  3. pmc Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways
    Xiaoyue Wang
    Department for Evolutionary Biology, Max Planck Institut for Developmental Biology, Tubingen, Germany
    PLoS Biol 9:e1001110. 2011
    ..We test this hypothesis by comparing vulva induction in two genetically tractable nematodes, Caenorhabditis elegans and Pristionchus pacificus...
  4. pmc Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network
    Erika Hoyos
    Center for Cell Dynamics, University of Washington, 620 University Road, Friday Harbor, WA 98250, USA
    Curr Biol 21:527-38. 2011
    ..Two seemingly conflicting verbal models of vulval precursor cell fate specification have been proposed: sequential induction by the EGF-MAP kinase and Notch pathways, or morphogen-based induction by the former...
  5. ncbi EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans
    R D Burdine
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8005, USA
    Development 125:1083-93. 1998
    ..egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles...
  6. ncbi Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
    Duo Wang
    Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 436:593-7. 2005
    ..These findings suggest that mutations in Rb pathway components cause cells to revert to patterns of gene expression normally restricted to germ cells. Rb may act by a similar mechanism to transform mammalian cells...
  7. pmc RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans
    Olga Skorobogata
    Division of Endocrinology and Metabolism, Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    PLoS ONE 7:e36489. 2012
    ..Here we used Caenorhabditis elegans vulva cell fate induction, a paradigm for genetic analysis of EGFR/Receptor Tyrosine Kinase (RTK) signaling, to assess ..
  8. ncbi MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction
    P B Tan
    Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
    Cell 93:569-80. 1998
    The let-23 receptor/mpk-1 MAP kinase signaling pathway induces the vulva in C. elegans. We show that MPK-1 directly regulates both the LIN-31 winged-helix and the LIN-1 Ets transcription factors to specify the vulval cell fate...
  9. ncbi Robustness and flexibility in nematode vulva development
    Marie Anne Felix
    Institut de Biologie de l Ecole Normale Supérieure, CNRS Inserm ENS, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Trends Genet 28:185-95. 2012
    The Caenorhabditis elegans vulva has served as a paradigm for how conserved developmental pathways, such as EGF-Ras-MAPK, Notch and Wnt signaling, participate in networks driving animal organogenesis...
  10. ncbi FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans
    David R Sherwood
    HHMI and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Cell 121:951-62. 2005
    ..These results reveal a key genetic network that controls basement-membrane removal during cell invasion...
  11. ncbi Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development
    Erik C Andersen
    Howard Hughes Medical Institute, Department of Biology, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Development 134:2991-9. 2007
    ..Our results suggest that in the inhibition of vulval development, homologs of SETDB1, HP1 and the NuRD complex act with this H3K36 HMT to prevent ectopic transcriptional initiation...
  12. pmc Opposing Wnt pathways orient cell polarity during organogenesis
    Jennifer L Green
    Howard Hughes Medical Institute Division of Biology, California Institute of Technology, Mail Code 156 29, Pasadena, CA 91125, USA
    Cell 134:646-56. 2008
    ..For example, mirror-image symmetry of the C. elegans vulva is achieved by the opposite division orientation of the vulval precursor cells (VPCs) flanking the axis of ..
  13. ncbi Anchor cell invasion into the vulval epithelium in C. elegans
    David R Sherwood
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Dev Cell 5:21-31. 2003
    ..These studies dissect the regulatory mechanisms that underlie a simple cell-invasive behavior in vivo, and introduce AC invasion as a model for understanding key checkpoints controlling cell invasion...
  14. ncbi The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
    D M Eisenmann
    Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA
    Development 125:3667-80. 1998
    ..Our genetic and molecular experiments show that the vulval precursor cells can integrate the input from the BAR-1 and LET-60 Ras signaling pathways by coordinately regulating activity of the common target LIN-39 Hox...
  15. ncbi A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development
    Byung Joon Hwang
    Howard Hughes Medical Institute and Division of Biology, 156 29 California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Development 131:143-51. 2004
    ....
  16. ncbi KIT pathway alterations in mucosal melanomas of the vulva and other sites
    Katarina Omholt
    Department of Oncology Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Cancer Res 17:3933-42. 2011
    ....
  17. ncbi The gene lin-3 encodes an inductive signal for vulval development in C. elegans
    R J Hill
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125
    Nature 358:470-6. 1992
    The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell...
  18. ncbi The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development
    Bhagwati P Gupta
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 130:2589-601. 2003
    ..Together, these findings demonstrate that temporal regulation of lin-11 is crucial for the wild-type vulval patterning...
  19. ncbi The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
    K Kornfeld
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 83:903-13. 1995
    ..The predicted KSR-1 protein has a protein kinase domain and is most similar to a recently identified Drosophila protein involved in Ras signaling. We propose that the function of ksr-1 is evolutionarily conserved...
  20. ncbi Cis regulatory requirements for vulval cell-specific expression of the Caenorhabditis elegans fibroblast growth factor gene egl-17
    Mingxue Cui
    Howard Hughes Medical Institute, and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 80309 0347, Boulder, CO, USA
    Dev Biol 257:104-16. 2003
    ..Interspecies transformation experiments showed that egl-17 cis-regulatory elements are structurally and functionally conserved between C. elegans and C. briggsae...
  21. ncbi The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
    R V Aroian
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Nature 348:693-9. 1990
    The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily...
  22. pmc Diversity in mating behavior of hermaphroditic and male-female Caenorhabditis nematodes
    L Rene Garcia
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    Genetics 175:1761-71. 2007
    ....
  23. ncbi Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11
    G Freyd
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nature 344:876-9. 1990
    ..The presence in these three proteins of both a potential metal-binding domain and a homeodomain distinguishes them from previously characterized proteins...
  24. pmc Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans
    Toshia R Myers
    Departments of Biological Sciences and Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:20368-73. 2007
    The Caenorhabditis elegans vulva has been a valuable paradigm for defining components of signaling pathways and elucidating how signaling events are coordinated to generate a developmental pattern...
  25. ncbi A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
    M M Barr
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Nature 401:386-9. 1999
    ..mating behaviour of the Caenorhabditis elegans male is made up of several substeps: response, backing, turning, vulva location, spicule insertion and sperm transfer...
  26. pmc Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase
    John H Yoder
    Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institution, University of Colorado, Boulder, CO, USA
    EMBO J 23:111-9. 2004
    ..Genetic analysis also indicates that PP2A phosphatase and PAR-1 kinase act downstream of Raf to positively and negatively regulate KSR activity, respectively...
  27. pmc C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival
    Ekaterini A Kritikou
    Institute of Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    Genes Dev 20:2279-92. 2006
    ..elegans germline and functions as a negative regulator of the MAPK signaling pathway during vulval development and in muscle cells...
  28. pmc Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans
    Gino Poulin
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
    EMBO J 24:2613-23. 2005
    ..In addition, we demonstrate a novel role for sumoylation in inhibiting LIN-12/Notch signalling in the vulva. We further show that many of the synMuv genes are involved in gene regulation outside the vulva, negatively ..
  29. ncbi dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development
    C J Ceol
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell 7:461-73. 2001
    ..We propose that rather than being inhibited by lin-35 Rb, dpl-1 DP and efl-1 E2F act with lin-35 Rb in transcriptional repression to antagonize RTK/Ras signaling during vulval development...
  30. ncbi Robustness and evolution: concepts, insights and challenges from a developmental model system
    M A Felix
    Institut Jacques Monod, CNRS Universities of Paris 6 7, Paris, France
    Heredity (Edinb) 100:132-40. 2008
    ..We here discuss key concepts related to robustness with examples from vulva development in the nematode Caenorhabditis elegans...
  31. ncbi Hakuna Nematoda: genetic and phenotypic diversity in African isolates of Caenorhabditis elegans and C. briggsae
    E S Dolgin
    Institute of Evolutionary Biology, University of Edinburgh, King s Buildings, Edinburgh, UK
    Heredity (Edinb) 100:304-15. 2008
    ..briggsae from sub-Saharan Africa. We characterize these samples for patterns of nucleotide polymorphism and vulva precursor cell lineage, and conduct a series of hybrid crosses in C...
  32. ncbi The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development
    Vincent Coustham
    Laboratoire de Biologie Moleculaire de la Cellule, Ecole Normale Superieure de Lyon, 69007 Lyon, France
    Dev Biol 297:308-22. 2006
    ..We further show by in vivo localization studies that LIN-13 is required for HPL-2 recruitment in nuclear foci. Our data suggest that the LIN-13/HPL-2 complex may physically link a subset of the Rb related synMuv proteins to chromatin...
  33. ncbi COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans
    W Hanna-Rose
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Development 126:169-79. 1999
    ..In screens for mutants defective in vulval morphogenesis, multiple mutants were isolated in which the uterus and the vulva fail to make a proper connection...
  34. pmc Comparison of the INNO-LiPA and PapType assays for detection of human papillomavirus in archival vulva dysplasia and/or neoplasia tissue biopsy specimens
    Sarah E Tan
    Department of Microbiology and Infectious Diseases, The Royal Women s Hospital, Victoria 3052, Australia
    J Clin Microbiol 49:3980-2. 2011
    ..The INNO-LiPA assay detected amplifiable DNA in 59 (91%) biopsy specimens, compared with 57 (88%) specimens for which amplifiable DNA was detected by the PapType assay. The two genotyping assays were highly comparable...
  35. ncbi Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva
    Alicia N Minniti
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Casilla 114 D, Santiago
    J Cell Sci 117:5179-90. 2004
    ..Mutations in all the genes that encode for GAG biosynthetic enzymes show defects in the development of the vulva, specifically in the invagination of the vulval epithelium...
  36. pmc The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins
    S G Clark
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Genetics 137:987-97. 1994
    ..locus lin-15 negatively regulates an intercellular signaling process that induces formation of the hermaphrodite vulva. The lin-15 locus controls two separate genetic activities...
  37. ncbi The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination
    T von Zelewsky
    Institute of Zoology, Department of Biology, University of Fribourg, Perolles, CH 1700 Fribourg, Switzerland
    Development 127:5277-84. 2000
    ....
  38. ncbi High sensitivity of C. elegans vulval precursor cells to the dose of posterior Wnts
    Jean Baptiste Pénigault
    Institut Jacques Monod, CNRS University Paris Diderot, 15 Rue Hélène Brion, 75205 Paris Cedex 13, France
    Dev Biol 357:428-38. 2011
    ..p competence without affecting their LIN-39 level. The centered vulval competence profile is thus under the control of the posterior Wnts and of cross-regulation of three HOM-C genes and prepatterns the later induction of vulval fates...
  39. pmc Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase
    A Hajnal
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 USA
    Genes Dev 11:2715-28. 1997
    During induction of the Caenorhabditis elegans hermaphrodite vulva, a signal from the anchor cell activates the LET-23 epidermal growth factor receptor (EGFR)/LET-60 Ras/MPK-1 MAP kinase signaling pathway in the vulval precursor cells...
  40. pmc Vulvovaginal-swab or first-catch urine specimen to detect Chlamydia trachomatis in women in a community setting?
    Sue Skidmore
    Public Health Laboratory Service, Birmingham Laboratory, Birmingham, UK
    J Clin Microbiol 44:4389-94. 2006
    ....
  41. pmc sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans
    Bhagwati P Gupta
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Genetics 174:1315-26. 2006
    ..We provide evidence that sli-3 interacts with the EGF signaling pathway components during vulval induction but not during viability and ovulation processes. Thus, sli-3 helps define specificity of the EGF signaling to induce the vulva.
  42. pmc The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression
    E F Hoier
    Division of Cancer Research, Department of Pathology, University of Zurich, CH 8091 Zurich, Switzerland
    Genes Dev 14:874-86. 2000
    ..Thus, APR-1 may positively regulate the activity of the beta-Catenin/Armadillo-related proteins HMP-2 in migrating epithelial cells and BAR-1 in the vulval precursor cells...
  43. pmc Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans
    J Shim
    Department of Biology, Yonsei University, Seoul, Korea
    Mol Biol Cell 11:2743-56. 2000
    ..Thus, apm-1 and unc-101 encode two highly related micro1 chains that share redundant and distinct functions within AP-1 clathrin-associated protein complexes of the same tissue...
  44. ncbi The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins
    Ning Chen
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Dev Cell 6:183-92. 2004
    ..In addition, we show that DSL-1, which lacks a predicted transmembrane domain, is a natural secreted ligand and can substitute for the transmembrane ligand LAG-2 in different functional assays...
  45. ncbi cis-Regulatory control of three cell fate-specific genes in vulval organogenesis of Caenorhabditis elegans and C. briggsae
    Martha Kirouac
    Howard Hughes Medical Institute and Division of Biology, Mail Code 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 257:85-103. 2003
    ..egl-17, zmp-1, and cdh-3 are expressed differentially in the developing vulva cells, providing a potential readout for different signaling pathways...
  46. ncbi Circulating basement membrane zone antibodies are found in lichen sclerosus of the vulva
    Anne Howard
    Dermatology Department, Western Hospital, Melbourne, Victoria, Australia
    Australas J Dermatol 45:12-5. 2004
    ..and clinical correlations in 96 patients attending the Oxford vulval clinic with lichen sclerosus (LS) of the vulva. Indirect immunofluorescence of serum (intact and split skin) to immunoglobulin (Ig)G was performed looking for ..
  47. ncbi Dissection of lin-11 enhancer regions in Caenorhabditis elegans and other nematodes
    Sujatha Marri
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    Dev Biol 325:402-11. 2009
    ..elegans has led to the identification of three functionally distinct enhancers for the vulva, VC neurons, and uterine pi lineage cells...
  48. pmc H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development
    Nora Koester-Eiserfunke
    Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    PLoS Genet 7:e1002017. 2011
    ..In vivo, H3K9me2/3 interaction of LIN-61 is required for C. elegans vulva development within the synMuvB pathway...
  49. pmc sli-1, a negative regulator of let-23-mediated signaling in C. elegans
    G D Jongeward
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Genetics 139:1553-66. 1995
    ..Our analysis suggests that let-23 can activate distinct signaling pathways in different tissues: one pathway is required for vulval induction; another pathway is involved in hermaphrodite fertility and is not regulated by sli-1...
  50. ncbi Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    Ben Lehner
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nat Genet 38:896-903. 2006
    ..We propose that these genes function as general buffers of genetic variation and that these hub genes may act as modifier genes in multiple, mechanistically unrelated genetic diseases in humans...
  51. pmc HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells
    Sonia Schott
    Ecole Normale Superieure de Lyon, Laboratory of Molecular and Cellular Biology, UMR5239, 69007 Lyon, France
    Genetics 181:797-801. 2009
    ..in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs)...
  52. pmc Bias and evolution of the mutationally accessible phenotypic space in a developmental system
    Christian Braendle
    Institut Jacques Monod, CNRS Universite Paris Diderot, Paris, France
    PLoS Genet 6:e1000877. 2010
    ..This study provides an empirical assessment of developmental bias and the evolution of mutationally accessible phenotypes and supports the notion that such bias may influence the directions of evolutionary change...
  53. ncbi Conserved mechanism of Wnt signaling function in the specification of vulval precursor fates in C. elegans and C. briggsae
    Ashwin Seetharaman
    Department of Biology, McMaster University, Hamilton, ON, Canada L8S 4K1
    Dev Biol 346:128-39. 2010
    The C. elegans hermaphrodite vulva serves as a paradigm for understanding how signaling pathways control organ formation. Previous studies have shown that Wnt signaling plays important roles in vulval development...
  54. ncbi Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development
    Julie E Gleason
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Dev Biol 298:442-57. 2006
    ..p lineage. Here, too, we found that four of five Wnt receptors can influence P7.p orientation, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C. elegans vulval induction...
  55. ncbi Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans
    Tony Oosterveen
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Dev Biol 308:438-48. 2007
    ..AXL-1 functions redundantly with PRY-1 in negatively regulating BAR-1/beta-catenin signaling in the developing vulva and the Q neuroblast lineage...
  56. pmc Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates
    Erik C Andersen
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 179:2001-12. 2008
    ..Many synMuv genes are evolutionarily conserved, and the genetic relationships we have identified might define the functions not only of synMuv genes in C. elegans but also of their homologs in other organisms...
  57. pmc Germ-line induction of the Caenorhabditis elegans vulva
    Beth E Thompson
    Cellular and Molecular Biology Program, Department of Biochemistry, and Howard Hughes Medical Institute, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:620-5. 2006
    Development of the Caenorhabditis elegans vulva serves as a paradigm for intercellular signaling during animal development...
  58. ncbi Transcriptional upregulation of the C. elegans Hox gene lin-39 during vulval cell fate specification
    Javier A Wagmaister
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Mech Dev 123:135-50. 2006
    ..Finally, we found that when the Wnt pathway is over activated, expression from the transcriptional lin-39::GFP increases, suggesting that the Wnt pathway also regulates lin-39 at the transcriptional level...
  59. ncbi Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein
    Kyunghee Koh
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Development 129:5171-80. 2002
    Development of the vulva in C. elegans is mediated by the combinatorial action of several convergent regulatory inputs, three of which, the Ras, Wnt and Rb-related pathways, act by regulating expression of the lin-39 Hox gene...
  60. ncbi The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway
    Jennifer L Green
    Division of Biology, California Institute of Technology, Mail Code 156 29, Pasadena, CA 91125, USA
    Development 134:4053-62. 2007
    ..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
  61. ncbi ARK-1 inhibits EGFR signaling in C. elegans
    N A Hopper
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Mol Cell 6:65-75. 2000
    ..We find that sem-5 also has a negative function in let-23-mediated ovulation and suggest that this negative function is mediated by the recruitment of inhibitors such as ARK-1...
  62. ncbi Evolution of a system sensitive to stochastic noise: P3.p cell fate in Caenorhabditis
    Jean Baptiste Pénigault
    Institut Jacques Monod, CNRS University Paris Diderot, 15 Rue Hélène Brion, 75205 Paris Cedex 13, France
    Dev Biol 357:419-27. 2011
    The C. elegans cell lineage is overall invariant. One rare instance of variability concerns P3.p, the most anterior vulva precursor cell, which may either fuse with the epidermis without dividing, or remain competent to form vulval ..
  63. pmc A cholinergic-regulated circuit coordinates the maintenance and bi-stable states of a sensory-motor behavior during Caenorhabditis elegans male copulation
    Yishi Liu
    Department of Biology, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 7:e1001326. 2011
    ..During mating, the Caenorhabditis elegans male cloaca is maintained over the hermaphrodite's vulva as he attempts to insert his copulatory spicules. Rhythmic spicule thrusts cease when insertion is sensed...
  64. ncbi C. elegans class B synthetic multivulva genes act in G(1) regulation
    Mike Boxem
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Curr Biol 12:906-11. 2002
    ..In contrast, lin-15B appeared to act in parallel to lin-35. Our results demonstrate the potential for genetic identification of novel G(1) regulators in C. elegans...
  65. ncbi LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction
    J S Simske
    Department of Developmental Biology, Stanford University Medical School, California 94305 5427, USA
    Cell 85:195-204. 1996
    In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway...
  66. ncbi The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development
    Lucie Yang
    Department of Biochemistry and Biophysics, University of California, San Francisco, Mission Bay Genentech Hall, 600 16th Street, Room S312A, San Francisco, CA 94143 2200, USA
    Development 132:1413-28. 2005
    ..ortholog of Homothorax (Hth/Meis/Prep), in two processes that are regulated by Hox gene lin-39: cell migration and vulva formation...
  67. pmc Transcriptional control of cell-cycle quiescence during C. elegans development
    Joseph E Clayton
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 313:603-13. 2008
    During the development of the C. elegans reproductive system, cells that give rise to the vulva, the vulval precursor cells (VPCs), remain quiescent for two larval stages before resuming cell division in the third larval stage...
  68. pmc The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development
    L S Huang
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 5:395-411. 1994
    ..We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal...
  69. ncbi The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling
    J N Maloof
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143 0554, USA
    Development 125:181-90. 1998
    ..In C. elegans, activation of the Ras pathway induces cells in the central body region to generate the vulva. Vulval induction takes place in the domain of the Hox gene lin-39...
  70. ncbi Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis
    Ho Yon Hwang
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Room 68 425, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 423:439-43. 2003
    ..So far much of the focus on glycosaminoglycans has been on heparan sulphate. Mutations in eight squashed vulva (sqv) genes in Caenorhabditis elegans cause defects in cytokinesis during embryogenesis and in vulval ..
  71. pmc The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells
    S M Kaech
    Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
    Cell 94:761-71. 1998
    ..Each of the binding interactions within this complex is conserved, suggesting that this complex may also mediate basolateral localization in mammals...
  72. pmc Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development
    D M Eisenmann
    Department of Developmental Biology, Stanford University, Stanford, California 94305, USA
    Genetics 156:1097-116. 2000
    The Caenorhabditis elegans vulva develops from the progeny of three vulval precursor cells (VPCs) induced to divide and differentiate by a signal from the somatic gonad...
  73. ncbi Lifetime changes in the vulva and vagina
    Miranda Farage
    The Procter and Gamble Company, Feminine Care Clinical Sciences, Winton Hill Technical Center, 6110 Center Hill Rd, Box 136, Cincinnati, OH 45224, USA
    Arch Gynecol Obstet 273:195-202. 2006
    The morphology and physiology of the vulva and vagina change over a lifetime. The most salient changes are linked to puberty, the menstrual cycle, pregnancy, and menopause...
  74. pmc A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction
    D S Sieburth
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309 0347, USA
    Genes Dev 13:2562-9. 1999
    ..Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling...
  75. pmc Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals
    C Chang
    HHMI and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 19:3283-94. 2000
    ..This SOS-1-independent signaling is not inhibited by SLI-1/Cbl and is not mediated by PTP-2/SHP, raising the possibility that there could be another RasGEF...
  76. ncbi Preliminary characterization of the normal microbiota of the human vulva using cultivation-independent methods
    Celeste J Brown
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844 3051, USA
    J Med Microbiol 56:271-6. 2007
    ..of this study was to perform a preliminary characterization of the microbial populations of the normal human vulva. Genomic DNA was isolated from samples of the labia majora and labia minora from four healthy women, and sequences ..
  77. pmc LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes
    Melissa M Harrison
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 176:255-71. 2007
    ..Our data indicate that while the class B synMuv genes act together to regulate vulval development, lin-61 functions separately from some class B synMuv proteins in other biological processes...
  78. ncbi Pattern formation during C. elegans vulval induction
    M Wang
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Top Dev Biol 51:189-220. 2001
    ..The temporal and spatial regulation of VPC competence and production of the inductive and the lateral signal are precisely coordinated to ensure the wild-type vulval pattern...
  79. ncbi SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans
    D S Sieburth
    Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, 80309 0347, USA
    Cell 94:119-30. 1998
    ..A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro...
  80. pmc Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction
    R V Aroian
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Genetics 128:251-67. 1991
    ..Since various let-23 mutant phenotypes can be obtained independently, the let-23 gene is likely to have tissue-specific functions...
  81. ncbi As good as they get: cells in nematode vulva development and evolution
    R J Sommer
    Max Planck Institute for Developmental Biology, Spemannstrasse 37 39, D 72076 Tubingen, Germany
    Curr Opin Cell Biol 13:715-20. 2001
    ..Genetic and molecular comparisons of nematode vulva development between Caenorhabditis, Pristionchus and Oscheius indicate that although the vulva is a stable organ, ..
  82. ncbi Sarcomatoid squamous cell carcinoma of the vulva expressing smooth muscle actin and S100 protein
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu Ku, Shizuoka 424 8636, Japan
    Arch Gynecol Obstet 283:1103-6. 2011
    ..Vulvar sarcomatoid squamous cell carcinoma has been rarely reported...
  83. ncbi Recurrent vulvovaginal candidosis: focus on the vulva
    Florian C Beikert
    IVDP German Center for Health Services Research in Dermatology, University Medical Center Hamburg, Hamburg, Germany
    Mycoses 54:e807-10. 2011
    ..Of 139 women, 105 (76%) had at least one C. albicans positive culture from the external vulva. Vulvar positive cultures correlated with pruritus (OR 5.4; P < 0.001), vulvar edema (OR 3.8; P = 0...
  84. ncbi PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulva
    Daryl D Hurd
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14580, USA
    Dev Biol 253:54-65. 2003
    The Caenorhabditis elegans vulva provides a simple model for the genetic analysis of pattern formation and organ morphogenesis during metazoan development...
  85. pmc The SynMuv genes of Caenorhabditis elegans in vulval development and beyond
    David S Fay
    University of Wyoming, College of Agriculture, Department of Molecular Biology, Dept 3944, 1000 E University Avenue, Laramie, WY 82071, USA
    Dev Biol 306:1-9. 2007
    For a nonessential diminutive organ comprised of only 22 nuclei, the Caenorhabditis elegans vulva has done very well for itself...
  86. ncbi Postcircumcision epidermoid inclusion cyst of the vulva containing multiple stones
    J Al-Maghrabi
    Department of Pathology, King Faisal Specialist Hospital and Research Center Jedah, P O Box 40047, Jeddah 21499, MBC J 52 Kingdom of Saudi Arabia
    Int J Gynaecol Obstet 90:155-6. 2005
  87. ncbi The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells
    A P Newman
    Howard Hughes Medical Institute, Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 126:5319-26. 1999
    The Caenorhabditis elegans hermaphrodite egg-laying system comprises several tissues, including the uterus and vulva. lin-11 encodes a LIM domain transcription factor needed for certain vulval precursor cells to divide asymmetrically...
  88. ncbi lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
    X Lu
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 95:981-91. 1998
    ..We propose that LIN-35 and LIN-53 antagonize the Ras signaling pathway in C. elegans by repressing transcription in the vulval precursor cells of genes required for the expression of vulval cell fates...
  89. ncbi Secondary corrections of the vulva in male-to-female transsexuals
    J J Hage
    Department of Plastic and Reconstructive Surgery at the Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
    Plast Reconstr Surg 106:350-9. 2000
    ..5-year period. In 86 of the 390 patients (22 percent), secondary corrections of the vulva were deemed necessary. A total of 130 corrections were performed in these 86 patients. In the same 17...
  90. ncbi Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome
    Caroline F Pukall
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, Canada
    Pain 96:163-75. 2002
    ..The data imply that VVS may reflect a specific pathological process in the vestibular region, superimposed on systemic hypersensitivity to tactile and pain stimuli...
  91. ncbi Impact of inguinal dissection on prognosis of early-stage squamous cell carcinoma of the vulva--a retrospective analysis
    J R Kouvaris
    Department of Radiology Radiotherapy, Aretaeion Hospital, University of Athens, Greece
    Onkologie 26:564-7. 2003
    ..Inclusion of inguinal lymphadenectomy in the surgical procedure is a potential prognostic factor for squamous cell vulvar carcinoma...
  92. ncbi The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development
    Gopal Battu
    Zoologisches Institut, Universitaet Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Development 130:2567-77. 2003
    ..Thus, SRA-13 may serve to adapt the activity of the RAS/MAPK pathway to environmental conditions...
  93. pmc A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development
    Florence Couteau
    Laboratory of Molecular and Cellular Biology, UMR5665 CNRS, Ecole Normale Superieure de Lyon, F 69364 Lyon, France
    EMBO Rep 3:235-41. 2002
    ..of the homologues, HPL-2, is required for the formation of a functional germline and for the development of the vulva by acting in an Rb-related pathway...
  94. ncbi The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval-uterine-epidermal connections
    A P Newman
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Biol 10:1479-88. 2000
    The development of a connection between the uterus and the vulva in the nematode Caenorhabditis elegans requires specification of a uterine cell called the utse, and its attachment to the vulva and the epidermal seam cells...
  95. ncbi Infantile pyramidal protrusion localized at the vulva as a manifestation of lichen sclerosus et atrophicus
    Buenaventura Hernandez-Machin
    J Am Acad Dermatol 56:S49-50. 2007
  96. pmc Predictive modeling of signaling crosstalk during C. elegans vulval development
    Jasmin Fisher
    School of Computer and Communication Sciences, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    PLoS Comput Biol 3:e92. 2007
    ..The insights gained by our modeling study further substantiate the usefulness of executing and analyzing mechanistic models to investigate complex biological behaviors...
  97. ncbi National audit of asymptomatic screening in UK genitourinary medicine clinics: clinic policies audit
    C A Carne
    BASHH, The Royal Society of Medicine, London, UK
    Int J STD AIDS 21:512-5. 2010
    ....
  98. pmc The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva
    Jolene S Fernandes
    Division of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS Genet 3:e69. 2007
    ..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
  99. ncbi Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 83:71-83. 2012
    ..parameters have been related to survival of patients with invasive squamous cell carcinoma of the vulva, whereas few studies have investigated the ability of biological variables to predict the clinical outcome of ..
  100. ncbi Primary extraskeletal myxoid chondrosarcoma of the vulva
    Morio Sawada
    Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan
    J Obstet Gynaecol Res 37:1706-10. 2011
    Primary extraskeletal myxoid chondrosarcoma (EMC) of the vulva is extremely rare. There is little available information about the biological behavior and treatment strategy for primary EMC of the vulva...
  101. ncbi High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva
    Irene A M van der Avoort
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Pathol 41:1475-85. 2010
    ..Furthermore, high p53 expression correlates with increased DNA content and aneuploidy; but it requires further research to unveil a possible causal relation...

Research Grants50

  1. Role of c-Met in SCLC and Potential for Novel Therapy
    Ravi Salgia; Fiscal Year: 2012
    ..elegans modeling system, we show that the JM domain c-Met mutants cause a dramatic phenotype related to the vulva, and is further activated with nicotine (an important component of cigarette smoke, and implicated in the ..
  2. Comparative and Cost-Effectiveness of Preventing HPV-Related Diseases
    JANE JOOYUN KIM; Fiscal Year: 2013
    ..in the United States;nearly 50% are cervical cancer, while the rest involve the oral cavity/oropharynx, anus, vulva, penis, and vagina...
  3. Longitudinal Population-Based Study of Vulvodynia
    Barbara D Reed; Fiscal Year: 2012
    ..hormonal exposures of women have been associated with the presence of vulvodynia and with pain sensitivity of the vulva, but results have been inconsistent...
  4. Probing functions of NAM and NAD+ salvage in development and aging in C. elegans
    Wendy Hanna-Rose; Fiscal Year: 2013
    ..For example, gonad development is delayed and the uterine vulva 1 (uv1) cells necrose. We aim to decipher how nicotinamidase influences development and longevity in the C...
  5. Regulation of the cell cycle and signaling by CUL-2 E3 complexes
    Edward T Kipreos; Fiscal Year: 2013
    ..elegans vulva, through the use of genetic analysis in combination with reporter transgenes...
  6. Localized Vulvodynia Pathogenesis: Fibroblast, Yeast, and Melanocortin
    Richard P Phipps; Fiscal Year: 2013
    ..Specific Aim 1: To determine whether pro-inflammatory fibroblasts segregate to painful areas of the vulva. Using lower genital tract pain mapping, we will discover whether pro-inflammatory fibroblasts localize to painful ..
  7. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..with a novel method of mechanical sensitivity testing whereby von Frey filaments are applied to the mouse vulva, located ventrally from the anogential ridge...
  8. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2001
    ..e. cervix, vagina, vulva,anus, penis, and scrotum) in adolescents infected with HIV and to compare the prevalence and severity of HPV ..
  9. Genetic Analysis of Nematode Behavior
    Scott W Emmons; Fiscal Year: 2013
    ..executed according to sensory input to allow the male to insert hardened spicules into the hermaphrodite vulva and transfer sperm...
  10. Characterization of Pain Processing in Vulvodynia
    Barbara Reed; Fiscal Year: 2009
    ..However, previous data from our group indicate increased sensitivity to pressure not only at the vulva, but also in the periphery (thumb, deltoid, and shin), suggesting that central mechanisms may be playing a role in ..
  11. Structure/Function of Human Papillomavirus Oncoproteins
    Ronen Marmorstein; Fiscal Year: 2006
    ..HPV infections are also implicated in other malignancies including cancer of the vulva, vagina, penis, anus, skin, esophagus, and oropharyngeal region...
  12. ONCOGENES & GROWTH FACTORS IN HUMAN GYNECOLOGIC CANCERS
    Lundy Braun; Fiscal Year: 1991
    ..oncogenes and growth factors in the pathogenesis of female genital tract cancers, particularly those of the vulva and cervix will be explored...
  13. Evolution of Axial Specification in Caenorhabditis
    SCOTT BAIRD; Fiscal Year: 2002
    ..to map and identify those genes responsible for ray pattern and vulva equivalence group evolution. These aims will be achieved through genetic analyses of C...
  14. Glycan alterations in C.elegans surface mutants
    Patricia Berninsone; Fiscal Year: 2003
    ..srf-4 (surface) are single loci mutants that have multiple defects, including uncoordinated movement, protruding vulva, abnormal egg laying, and defective copulatory bursae and gonad morphology, yet they were isolated based on their ..
  15. HPV IN CONJUNCTIVAL SQUAMOUS DYSPLASIA AND CARCINOMA
    JAN MCDONNELL; Fiscal Year: 1992
    ..as possible causative agents in the development of proliferative squamous lesions of the uterine cervix, vulva, anus, larynx, and tongue...
  16. A new gene family as modifiers of polycystin signaling
    Renee Miller; Fiscal Year: 2009
    ..which requires intact polycystins for two distinct steps, response to contact and location of the hermaphrodite vulva. We have recently discovered five new genes named cwp1-5, expressed exclusively in male worms in the identical set ..
  17. GENETIC CONTROL OF NEMATODE VULVAL DEVELOPMENT
    Paul Sternberg; Fiscal Year: 1999
    DESCRIPTION: This application is to study pattern formation during development of the nematode vulva. Previous work has shown that the product of the lin-3 gene, an EGF homolog, acts as a secreted morphogen in this system...
  18. Formal Modeling, Simulation and Analysis of C. elegans
    Amir Pnueli; Fiscal Year: 2006
    ..These components include the gonad, the vulva, the egg-laying muscles, and the HSN neurons...
  19. Identification of Wnt signal target genes in C. elegans
    BELINDA JACKSON; Fiscal Year: 2009
    ..In C. elegans this leads to the formation of the hermaphrodite vulva and possibly ventral cord neuron cell identity...
  20. Regulation of EGFR signaling in C. Elegans
    Andres Maricq; Fiscal Year: 2009
    ..elegans. Precise patterning of the vulva requires EGFR signaling to be subjected to all 3 layers of regulation...
  21. REGULATION OF GENE EXPRESSION DURING ORGANOGENESIS
    Helen Chamberlin; Fiscal Year: 2004
    ..elegans. A third aim is to functionally characterize this second gene to determine whether its product shares in vivo functions with EGL-38, or whether it regulates lin-48 and cdh-3 expression in other organs. ..
  22. Genetic Regulation of Mating Behavior in C. elegan Males
    Luis Garcia; Fiscal Year: 2009
    ..of many steps, this project will focus on dissecting how the male inserts his spicules into his mate's vulva. Spicule insertion behavior is a simple reflex;however, the male nervous system and musculature must regulate many ..
  23. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2006
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  24. VULVODYNIA PREVALENCE AND EFFICACY OF 4 INTERVENTIONS
    Gloria Bachmann; Fiscal Year: 2004
    ..Our ultimate goal is to share findings from this and related research with the broadest cross-spectrum of women that we can. ..
  25. GENES CONTROLLING DEVELOPMENT OF TISSUE SPECIALIZATION
    ANNA NEWMAN; Fiscal Year: 2003
    ..Development of the two uterine cell types (called utse and uv1) that connect to the vulva and the intermediate precursor cell (called pi) that produces them involves strategies used broadly in the ..
  26. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2009
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..
  27. COGNITIVE-BEHAVIORAL THERAPY FOR VULVODYNIA
    Robin Masheb; Fiscal Year: 2002
    ..Clinically, results from this study may provide a justified treatment option for women with vulvodynia. ..
  28. Ras/ERK control of cell fates
    MEERA VEDAVALLI SUNDARAM; Fiscal Year: 2010
    ..elegans, where Ras-ERK specifies the fates of the excretory duct, P12 ectoblast, vulva and other tissues...
  29. Acquisition and Natural History of Genital HPV Infection
    Laura Koutsky; Fiscal Year: 2009
    ..In summary, the long-range goal of this project is to improve the effectiveness of both vaccine-based and behavioral strategies for preventing HPV infection. ..
  30. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women. ..
  31. Substrate specific ERK docking domain inhibitors
    Paul S Shapiro; Fiscal Year: 2010
    ..These compounds will be appropriate for research tools and the development into novel chemotherapeutic agents aimed at treating cancers associated with elevated ERK pathway activity. ..
  32. CBT and Dieting: Effects on Psychopathology and Weight in BED
    Robin Masheb; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  33. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. A Female Mouse Model to Study Recurrent Genital Herpes
    Margaret Parr; Fiscal Year: 2002
    ..abstract_text> ..
  35. Functional Genomics:Complex Biological Systems
    Stuart Kim; Fiscal Year: 2003
    ..The goal of the meeting is to integrate advances in human disease, modeling of genetic networks, quantitative trait mapping, and data mining techniques. ..
  36. HPV Testing--Self-Collected Samples for Cervical Cancer
    Laura Koutsky; Fiscal Year: 2003
    ....
  37. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
  38. Spinning Microlens Confocal Microscope
    William Mohler; Fiscal Year: 2004
    ..Bruce Mayer will visualize actin cytoskeletal changes induced by aggregation of signaling oroteins, as well as dvnamic colocalization and orotein interaction bv FRET in vivo. ..
  39. PROTEIN PHOSPHATASE 2A REGULATION OF RAS SIGNALING
    Meera Sundaram; Fiscal Year: 2004
    ..We will use C. elegans vulva development as a genetic model system to elucidate how PP2A-B subunits regulate PP2A catalytic activity and/or ..
  40. Analysis of sperm transfer behavior in C elegans
    Gary Schindelman; Fiscal Year: 2004
    ..These questions will be investigated by means of surgical and genetic methods. ..
  41. Development of ERK docking domain inhibitors
    Paul Shapiro; Fiscal Year: 2005
    ..These studies represent a novel approach for developing compounds that selectively block ERK activation of proteins involved in cancer cell proliferation. ..
  42. RNA Analysis of HPV Viral Loads
    Laura Koutsky; Fiscal Year: 2005
    ....
  43. Reproductive Hormonal Effects of Weight Loss in Women
    Nanette Santoro; Fiscal Year: 2005
    ..Thus, this initial exploration, if positive, would provide the basis for a new line of investigation for the PI into the interactions between reproduction and metabolism. ..
  44. NEUROBIOLOGICAL EFFECT OF LONG-TERM ESTROGEN REPLACEMENT
    Yolanda Smith; Fiscal Year: 2006
    ..Comparison between groups will offer a greater understanding of the effect of hormone therapies on brain neurochemistry and cognition. ..
  45. Function of the protein EFF-1 in cell membrane fusion
    William Mohler; Fiscal Year: 2007
    ..Our results will increase understanding of the molecular mechanism underlying developmental cell fusion, a crucial and under-explored component of animal reproduction, development, and health. ..
  46. Regulation and Function of Hox gene lin-39 in C elegans
    DAVID EISENMANN; Fiscal Year: 2007
    ..elegans, for which full genomic sequence is available and functional genomic approaches are available. ..
  47. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2007
    ..Clear public health benefits will accrue from development of more accurate and less costly screening tests. ..
  48. Effect of Oxidant Load on HPV Persistence and CIN (SIL)
    Anna Giuliano; Fiscal Year: 2008
    ..abstract_text> ..
  49. Breeding status and delayed motoneuron maturation in a eusocial mammal
    Marianne Seney; Fiscal Year: 2008
    ..This information could be used to develop treatments for degenerative diseases characterized by loss or atrophy of motoneurons, such as amyotrophic lateral sclerosis (ALS). [unreadable] [unreadable] [unreadable]..
  50. 2001 International C. elegans Meeting
    Paul Sternberg; Fiscal Year: 2001
    ..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones, and have been vital in fostering the sense of excitement, collegiality and cooperativity that characterize this field. ..