endometrium

Summary

Summary: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing EMBRYO.

Top Publications

  1. pmc VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
  2. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
  3. pmc Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium
    Caroline E Gargett
    Department of Obstetrics and Gynaecology and Centre for Women s Health Research, Monash Institute of Medical Research, Monash University, Victoria, Australia
    Biol Reprod 80:1136-45. 2009
  4. ncbi Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential
    Bruno Borghese
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Mol Endocrinol 22:2557-62. 2008
  5. ncbi Progesterone and interferon-tau regulate cystatin C in the endometrium
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:3478-83. 2006
  6. ncbi Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives
    Birgit Gellersen
    Endokrinologikum Hamburg, Hamburg, Germany
    Semin Reprod Med 25:445-53. 2007
  7. ncbi Endometrial receptivity markers, the journey to successful embryo implantation
    Hanna Achache
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel
    Hum Reprod Update 12:731-46. 2006
  8. pmc Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
    Madhuri Salker
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 5:e10287. 2010
  9. ncbi Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle
    S Battersby
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:2463-9. 2004
  10. ncbi Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation
    N Forde
    School of Agriculture, Food Science, and Veterinary Medicine, and Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 84:266-78. 2011

Detail Information

Publications349 found, 100 shown here

  1. pmc VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
    ..and regulation by steroid hormones, the lack of clear understanding of the mechanisms of angiogenesis in the endometrium is a major limitation for use of antiangiogenic therapy targeting endometrial vessels...
  2. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
    ..Our aim was to identify specific miRNAs that are expressed in endometrium of women with and without endometriosis...
  3. pmc Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium
    Caroline E Gargett
    Department of Obstetrics and Gynaecology and Centre for Women s Health Research, Monash Institute of Medical Research, Monash University, Victoria, Australia
    Biol Reprod 80:1136-45. 2009
    Human endometrium is a highly regenerative tissue undergoing more than 400 cycles of growth, differentiation, and shedding during a woman's reproductive years. Endometrial regeneration is likely mediated by adult stem/progenitor cells...
  4. ncbi Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential
    Bruno Borghese
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Mol Endocrinol 22:2557-62. 2008
    ..The objective of this study is to characterize the transcriptome differences between eutopic vs. ectopic endometrium with a special interest in pathways involved in cancerogenesis...
  5. ncbi Progesterone and interferon-tau regulate cystatin C in the endometrium
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:3478-83. 2006
    ..inhibitor of lysosomal cysteine proteases cathepsins B (CTSB) and CTSL, which are abundant in the ovine endometrium and conceptus. In mice, cathepsins and cystatins play important roles in implantation and placentation...
  6. ncbi Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives
    Birgit Gellersen
    Endokrinologikum Hamburg, Hamburg, Germany
    Semin Reprod Med 25:445-53. 2007
    ..This raises the possibility that biochemical analysis of timed endometrial biopsy samples taken in a nonconception cycle could be informative of subsequent pregnancy outcome...
  7. ncbi Endometrial receptivity markers, the journey to successful embryo implantation
    Hanna Achache
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel
    Hum Reprod Update 12:731-46. 2006
    ..a three-stage process (apposition, adhesion and invasion) involving synchronized crosstalk between a receptive endometrium and a functional blastocyst...
  8. pmc Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
    Madhuri Salker
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 5:e10287. 2010
    ....
  9. ncbi Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle
    S Battersby
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:2463-9. 2004
    ..discovered endocrine gland-derived vascular endothelial growth factors and their cognate receptors in the human endometrium during the menstrual cycle...
  10. ncbi Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation
    N Forde
    School of Agriculture, Food Science, and Veterinary Medicine, and Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 84:266-78. 2011
    ..This study aimed to: 1) describe the transcriptional changes that occur in the bovine endometrium during the estrous cycle, 2) determine how elevated P4 affects these changes, 3) identify if low P4 alters the ..
  11. ncbi Altered gene expression profiling in endometrium: evidence for progesterone resistance
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0132, USA
    Semin Reprod Med 28:51-8. 2010
    ..Indeed, aberrant expression of progesterone-regulated genes in the endometrium has been implicated in several gynecologic disorders, including endometriosis, polycystic ovarian syndrome (..
  12. ncbi Hormonal induction of endometrial receptivity
    Richard J Paulson
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Fertil Steril 96:530-5. 2011
    ..To review and synthesize information from the scientific literature pertaining to the hormonal induction of endometrial receptivity before ET...
  13. ncbi Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2), on gene expression in bovine endometrium
    Stefan Bauersachs
    Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Germany
    Biol Reprod 86:46. 2012
    ..In experiment 2, IFNA2 treatment resulted in differential gene expression in the bovine endometrium. Comparison of the data sets from both studies identified genes that were differentially expressed in response ..
  14. ncbi Expansion of human trophoblastic spheroids is promoted by decidualized endometrial stromal cells and enhanced by heparin-binding epidermal growth factor-like growth factor and interleukin-1 β
    Marina González
    Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Mol Hum Reprod 17:421-33. 2011
    ..We suggest that decidualized ESC support trophoblast invasion by paracrine signals that may include HB-EGF, IL-1β and LIF...
  15. ncbi Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obsterics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:681-7. 2007
    Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue endometriosis play critical physiologic roles...
  16. ncbi Models for study of human embryo implantation: choice of cell lines?
    Natalie J Hannan
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Biol Reprod 82:235-45. 2010
    ..While a number of cell lines for both endometrium and trophoblast have been developed and are widely used, it is difficult for researchers to decide which of ..
  17. ncbi Analysis of fertility-related soluble mediators in human uterine fluid identifies VEGF as a key regulator of embryo implantation
    N J Hannan
    Prince Henry s Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Endocrinology 152:4948-56. 2011
    Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced soluble mediators...
  18. ncbi The molecular basis of recurrent pregnancy loss: impaired natural embryo selection
    G Teklenburg
    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Mol Hum Reprod 16:886-95. 2010
    ..These uterine factors are, however, poorly defined. The ability of a conceptus to implant in the endometrium is normally restricted to a few days in the menstrual cycle...
  19. pmc Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle
    Rob D Catalano
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:182-92. 2011
    ..the prostanoid receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGDR, GPR44, PTGIR and TBXA2R) in the human endometrium throughout the menstrual cycle...
  20. ncbi Hypoxia-inducible factor-1alpha expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2)
    Hilary O D Critchley
    University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Building, Scotland, UK
    Endocrinology 147:744-53. 2006
    ..We hypothesize that HIF-1 is expressed in human endometrium and that locally synthesized prostaglandins (PGE2 and PGF(2alpha)) regulate HIF-1 activity...
  21. ncbi Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
    Huijian Wu
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    Nature 438:981-7. 2005
    ..we identify a paired-box gene, PAX2, that is crucially involved in cell proliferation and carcinogenesis in the endometrium. Our experiments show that PAX2 is activated by oestrogen and tamoxifen in endometrial carcinomas but not in ..
  22. ncbi Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2
    Mitsutoshi Tamura
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
    J Clin Endocrinol Metab 87:3263-73. 2002
    ..Moreover, posttranscriptional mRNA stability is an important mechanism for IL-1beta-induced elevation of COX-2 expression in ESC...
  23. pmc Stem cell-like properties of the endometrial side population: implication in endometrial regeneration
    Hirotaka Masuda
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 5:e10387. 2010
    The human endometrium undergoes cyclical regeneration throughout a woman's reproductive life...
  24. ncbi Putative stem cell activity of human endometrial epithelial and stromal cells during the menstrual cycle
    Kjiana Elkje Schwab
    Department of Obstetrics and Gynaecology, Centre for Women s Health Research, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Fertil Steril 84:1124-30. 2005
    ..To determine whether menstrual cycle stage or activity has an effect on the clonogenic activity of human endometrial epithelial and stromal cells...
  25. ncbi Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation
    Anne E King
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, United Kingdom EH16 4SB
    J Clin Endocrinol Metab 88:4426-31. 2003
    ..This study details the expression and regulation of elafin in the human endometrium. Elafin mRNA and protein expression were examined in endometrium throughout the menstrual cycle and in first-..
  26. ncbi Human uterine stem/progenitor cells: their possible role in uterine physiology and pathology
    Tetsuo Maruyama
    Department of Obstetrics and Gynaecology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Reproduction 140:11-22. 2010
    The human uterus mainly consists of the endometrium and the outer smooth muscle layer termed the myometrium...
  27. ncbi Characterization of clonogenic stromal cells isolated from human endometrium
    R Dimitrov
    Department of Immunochemistry, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Reproduction 135:551-8. 2008
    Human endometrium is an object of extensive restructuring and remodeling during the female reproductive life and it is quite tempting to assume that these periodic changes happen with the participation of cells that should have the basic ..
  28. pmc Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation
    Chang Hao Cui
    Department of Reproductive Biology and Pathology, National Institute for Child Health and Development, Tokyo, 157 8535, Japan
    Mol Biol Cell 18:1586-94. 2007
    ..These results demonstrate that the endometrial progenitor cells and menstrual blood-derived cells can transfer dystrophin into dystrophied myocytes through cell fusion and transdifferentiation in vitro and in vivo...
  29. pmc Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration
    Seema Grewal
    Nuffield Department of Obstetrics and Gynecology, University of Oxford, Level 3, Women s Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 105:16189-94. 2008
    ..These results reveal embryo-induced and localized endometrial responses that may govern implantation of the human embryo...
  30. ncbi Bovine pretransfer endometrium and embryo transcriptome fingerprints as predictors of pregnancy success after embryo transfer
    Dessie Salilew-Wondim
    Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Endenicher Allee 15, Bonn, Germany
    Physiol Genomics 42:201-18. 2010
    Aberrant gene expression in the uterine endometrium and embryo has been the major causes of pregnancy failure in cattle...
  31. ncbi Comparative aspects of implantation
    Fuller W Bazer
    Department of Animal Science Veterinary Integrative Biosciences, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Reproduction 138:195-209. 2009
    ....
  32. ncbi Identification of genes regulated by interleukin-1beta in human endometrial stromal cells
    Marco Rossi
    Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine, University of Siena, Italy
    Reproduction 130:721-9. 2005
    Interleukin-1beta (IL-1b) is an important immune regulatory factor that in human endometrium plays a role in both menstruation and implantation in the event of pregnancy...
  33. ncbi Effects of lactation and pregnancy on gene expression of endometrium of Holstein cows at day 17 of the estrous cycle or pregnancy
    R L A Cerri
    Department of Animal Sciences, University of Florida, Gainesville, FL 32611, USA
    J Dairy Sci 95:5657-75. 2012
    ..The stated genes associated with immune function and developmental genes expressed in the endometrium affected by lactational state are possible candidate genes for interventions to improve fertility of lactating ..
  34. ncbi Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure
    Madhuri S Salker
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Nat Med 17:1509-13. 2011
    ..is upregulated in unexplained infertility, most prominently in the luminal epithelium, but downregulated in the endometrium of women suffering from RPL...
  35. ncbi Global gene profiling in human endometrium during the window of implantation
    L C Kao
    Department of Gynecology and Obstetrics, Stanford University, Stanford, California 94305, USA
    Endocrinology 143:2119-38. 2002
    ..several genes and gene products that may participate in this process have been identified in secretory phase endometrium. Herein, we have investigated global gene expression during the window of implantation (peak E2 and ..
  36. ncbi Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle
    N Forde
    School of Agriculture, Food Science and Veterinary Medicine, Conway Institute, College of Life Sciences, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 81:784-94. 2009
    ....
  37. ncbi Transcriptomic analysis of the bovine endometrium: What is required to establish uterine receptivity to implantation in cattle?
    Niamh Forde
    School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland
    J Reprod Dev 58:189-95. 2012
    ..During this time, carefully orchestrated spatio-temporal alterations in the transcriptomic profile of the endometrium are required to drive conceptus elongation, via secretions from the endometrium (termed histotroph) and ..
  38. ncbi Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium
    James G Cronin
    Institute of Life Science, School of Medicine, Swansea University, United Kingdom
    Biol Reprod 86:51. 2012
    Infection of the bovine endometrium with Gram-negative bacteria commonly causes uterine disease...
  39. ncbi Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy
    S Bauersachs
    Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich, Germany
    Exp Clin Endocrinol Diabetes 116:371-84. 2008
    The endometrium undergoes marked functional changes during estrous cycle and pregnancy...
  40. ncbi Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium
    K E Schwab
    Centre for Women s Health Research, Monash Institute of Medical Research, Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, Australia
    Hum Reprod 22:2903-11. 2007
    Human endometrium has immense regenerative capacity, growing ~5 mm in 7 days every month. We have previously identified a small population of colony-forming endometrial stromal cells which we hypothesize are mesenchymal stem cells (MSC)...
  41. pmc Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium
    Banghyun Lee
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 80:79-85. 2009
    The eutopic endometrium in women with endometriosis demonstrates diminished endometrial receptivity and altered gene expression...
  42. ncbi Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 79:1226-36. 2008
    ..Therefore, FGF10, MET, IGFBP1, and IGFBP3 are P4-regulated factors within the endometrium of the ovine uterus that have potential effects on endometrial function and peri-implantation blastocyst growth ..
  43. ncbi 900 MHz radiofrequency-induced histopathologic changes and oxidative stress in rat endometrium: protection by vitamins E and C
    Mehmet Guney
    Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    Toxicol Ind Health 23:411-20. 2007
    ..In the EMR group histopathologic changes in endometrium, diffuse and severe apoptosis was present in the endometrial surface epithelial and glandular cells and the ..
  44. ncbi Hormone and growth factor signaling in endometrial renewal: role of stem/progenitor cells
    Caroline E Gargett
    Centre for Women s Health Research, Monash Institute of Medical Research, Monash University, Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria Australia
    Mol Cell Endocrinol 288:22-9. 2008
    The human endometrium is a dynamic remodeling tissue undergoing more than 400 cycles of regeneration, differentiation and shedding during a woman's reproductive years...
  45. pmc The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2
    Quanxi Li
    Department of Comparative Biosciences, University of Illinois Urbana Champaign, Urbana, IL 61820, USA
    Science 331:912-6. 2011
    ..Thus, Hand2 is a critical regulator of the uterine stromal-epithelial communication that directs proper steroid regulation conducive for the establishment of pregnancy...
  46. ncbi Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors
    Mohan Singh
    Research Group in Molecular Oncology and Endocrinology, Department of Chemistry Biology, University of Quebec, Trois Rivieres, 3351, Boulevard des Forges, CP 500, Trois Rivieres, Quebec G8Y 5H7, Canada
    J Endocrinol 210:5-14. 2011
    ..achieving the appropriate embryo development to the blastocyst stage and at the same time the development of an endometrium that is receptive to the embryo...
  47. ncbi Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing
    Ai Guo Sha
    Reproductive Medicine Center, Bailu Hospital, Xiamen, People s Republic of China
    Fertil Steril 96:150-155.e5. 2011
    ..To identify microRNAs (miRNAs) associated with endometrial receptivity...
  48. ncbi Decidualized endometrial stromal cell derived factors promote trophoblast invasion
    Geeta Godbole
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Parel, Mumbai, India
    Fertil Steril 95:1278-83. 2011
    ..To evaluate the effects of decidua-derived factors on trophoblast invasion...
  49. ncbi Adult stem cells in the endometrium
    Caroline E Gargett
    Department of Obstetrics and Gynaecology and The Ritchie Centre, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton, Vic, 3168, Australia
    Mol Hum Reprod 16:818-34. 2010
    Rare cells with adult stem cell activity were recently discovered in human endometrium. Endometrial stem/progenitor cell candidates include epithelial, mesenchymal and endothelial cells, and all may contribute to the rapid endometrial ..
  50. ncbi Endometrial NK cells are special immature cells that await pregnancy
    Irit Manaster
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Biomedical Research Institute, Jerusalem, Israel
    J Immunol 181:1869-76. 2008
    NK cells populate the human endometrium before pregnancy. Unlike decidual NK cells that populate the decidua during pregnancy, the NK cells present in the human endometrium, before pregnancy, have not been fully characterized...
  51. pmc Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor
    Jemma Evans
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    FASEB J 23:2165-75. 2009
    Implantation requires communication between a receptive endometrium and a healthy blastocyst. This maternal-embryonic crosstalk involves local mediators within the uterine microenvironment...
  52. ncbi Endometrial glands are required for preimplantation conceptus elongation and survival
    C A Gray
    Center for Animal Biotechology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843-2471, USA
    Biol Reprod 64:1608-13. 2001
    ..Collectively, these results demonstrate that endometrial glands and, by inference, their secretions are required for periimplantation conceptus survival and development...
  53. pmc Endometrial decidualization: of mice and men
    Cyril Y Ramathal
    Department of Cell and Developmental Biology, University of Illinois Urbana Champaign, Urbana, Illinois 61801, USA
    Semin Reprod Med 28:17-26. 2010
    ..human pregnancies, embryos implant by attaching to the luminal epithelium and invading into the stroma of the endometrium. Under the influence of the steroid hormones estrogen and progesterone, the stromal cells surrounding the ..
  54. ncbi Antiangiogenesis therapy for endometriosis
    Annemiek W Nap
    Department of Obstetrics and Gynecology, Research Institute for Growth and Development, Maastricht University and University Hospital, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:1089-95. 2004
    ..We show that human endometrium in the proliferative endometrium is highly angiogenic and that vascular endothelial growth factor-A is the most ..
  55. ncbi Analysis of osteopontin at the maternal-placental interface in pigs
    Jane E Garlow
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 66:718-25. 2002
    ..Both 70- and 45-kDa forms of OPN protein were detected in cyclic and pregnant endometrium by Western blotting...
  56. ncbi Clonogenicity of human endometrial epithelial and stromal cells
    Rachel W S Chan
    Centre for Women s Health Research, Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Biol Reprod 70:1738-50. 2004
    The human endometrium regenerates from the lower basalis layer, a germinal compartment that persists after menstruation to give rise to the new upper functionalis layer...
  57. ncbi Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep
    G A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843 2471, USA
    Biol Reprod 65:820-8. 2001
    ....
  58. ncbi Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon
    Rebecca T Marquez
    Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:6116-26. 2005
    ..malignant transformation, different histotypes arise that resemble epithelial cells from normal fallopian tube, endometrium, and intestine...
  59. ncbi Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells
    K E Schwab
    Centre for Women s Health Research, Monash Institute of Medical Research and Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria, Australia
    Hum Reprod 23:934-43. 2008
    Human endometrium is a highly regenerative tissue. We hypothesized that the source of endometrial stromal and vascular regeneration is a resident stromal stem/progenitor cell population...
  60. ncbi Non-genomic progesterone actions in female reproduction
    B Gellersen
    Endokrinologikum Hamburg, Hamburg, Germany
    Hum Reprod Update 15:119-38. 2009
    ..This review covers our current knowledge on the mechanisms and relevance of non-genomic progesterone signalling in female reproduction...
  61. ncbi Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women
    S Talbi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, Parnassus, M1495, Box 0132, San Francisco, California 94143 0132, USA
    Endocrinology 147:1097-121. 2006
    Histological evaluation of endometrium has been the gold standard for clinical diagnosis and management of women with endometrial disorders...
  62. pmc Prokineticin 1 signaling and gene regulation in early human pregnancy
    Jemma Evans
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:2877-87. 2008
    ..The objective of this study was to investigate the role of PROK1 and prokineticin receptor 1 (PROKR1) in human endometrium during early pregnancy...
  63. ncbi DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen
    Yoshiaki Yamagata
    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1 1 1, Ube 755 8505, Japan
    Hum Reprod 24:1126-32. 2009
    ..regulation may be involved in modulation of gene expression during the normal cyclic changes of the human endometrium. We investigated expression of DNA methyltransferases (DNMTs) in endometrium during the menstrual cycle and the ..
  64. pmc Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium
    Satu Kuokkanen
    Department of Obstetrics and Gynecology and Women s Health, Cooperative Center for the Study of Reproduction and Infertility Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biol Reprod 82:791-801. 2010
    ..Because the expression of miRNAs in human endometrium has been established, it is important to understand whether miRNAs have a physiological role in modulating the ..
  65. pmc Wnt signalling in implantation, decidualisation and placental differentiation--review
    S Sonderegger
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Placenta 31:839-47. 2010
    ..Hence, much remains to be learned about the role of different Wnt signalling cascades in reproductive cell types and their changes under pathological conditions...
  66. ncbi Contribution of bone marrow-derived stem cells to endometrium and endometriosis
    Hongling DU
    Division of Reproductive Endocrinology, Department of Medicine, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Stem Cells 25:2082-6. 2007
    ..Donor-derived bone marrow cells have been identified in human uterine endometrium. Here, two murine models were used to investigate the contribution of nonendometrial stem cells to endometrium...
  67. ncbi Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis
    Richard O Burney
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
    Endocrinology 148:3814-26. 2007
    The identification of molecular differences in the endometrium of women with endometriosis is an important step toward understanding the pathogenesis of this condition and toward developing novel strategies for the treatment of ..
  68. ncbi Oct-4 expression in human endometrium
    C Matthai
    Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Waehringer Guertel, Vienna, Austria
    Mol Hum Reprod 12:7-10. 2006
    ..Thus, we investigated the expression of Oct-4 comparing its occurrence in endometrium of healthy and diseased women using immunohistochemistry (IHC) and RT-PCR...
  69. ncbi Interleukin-11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation
    M Marwood
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, Victoria, Australia
    Endocrinology 150:2915-23. 2009
    ..IL-11 and leukemia inhibitory factor (LIF), two IL-6 family cytokines, are produced by the endometrium and are absolutely required for implantation in mice...
  70. ncbi Localization of angiogenic growth factors and their receptors in the human endometrium throughout the menstrual cycle and in recurrent miscarriage
    Gendie E Lash
    Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, 3rd Floor, William Leech Building, Newcastle upon Tyne NE2 4HH, UK
    Hum Reprod 27:183-95. 2012
    ..Angiogenesis is a key feature of endometrial development. Inappropriate endometrial vascular development has been associated with recurrent miscarriage (RM) with increased amounts of perivascular smooth muscle cells surrounding them...
  71. ncbi A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies
    N Gleicher
    The Center for Human Reproduction, New York and the Foundation for Reproductive Medicine, New York, NY 10021, USA
    Hum Reprod 28:172-7. 2013
    Is thin endometrium unresponsive to standard treatments expandable by intrauterine perfusion with granulocyte colony-stimulating factor (G-CSF)?
  72. ncbi Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
    ..The OPN mRNA in total ovine endometrium increased 30-fold between Days 40 and 80 of gestation...
  73. pmc Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey
    Ji Long Liu
    Department of Biology, Shantou University, Shantou 515063, China
    J Biol Chem 287:13899-910. 2012
    ..Surprisingly, about 50% of the 10,677 genes expressed in the rhesus monkey endometrium exhibited alternative 3'-UTRs...
  74. ncbi Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau
    N Forde
    School of Agriculture and Food Science, University College Dublin, Belfield, Dublin, Ireland
    Physiol Genomics 44:799-810. 2012
    The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and ..
  75. ncbi Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium
    T E Spencer
    Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Endocrinology 137:1144-7. 1996
    ..IFNtau acts as an antiestrogen on the endometrium to suppress increases in estrogen receptor (ER) and oxytocin receptor (OTR) gene expression which prevents ..
  76. ncbi Pinopodes, leukemia inhibitory factor, integrin-β3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss
    Bufang Xu
    Reproductive Medical Center of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Fertil Steril 98:389-95. 2012
    ..morphology and coverage, and expression of leukemia inhibitory factor (LIF), integrin-β3, and mucin-1 (MUC1) in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss (RPL) versus normal fertile women.
  77. pmc MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis
    R O Burney
    Division of Reproductive Endocrinology and Infertility, Madigan Army Medical Center, Tacoma, WA, USA
    Mol Hum Reprod 15:625-31. 2009
    ..of progesterone target genes and maintenance of a proliferative molecular fingerprint in the early secretory endometrium (ESE) has been reported...
  78. ncbi Molecular classification of human endometrial cycle stages by transcriptional profiling
    Anna P Ponnampalam
    Centre for Women s Health Research, Monash University Department of Obstetrics and Gynaecology, 246 Clayton Road, Victoria 3168, Australia
    Mol Hum Reprod 10:879-93. 2004
    b>Endometrium is a dynamic tissue that undergoes cyclic changes each month, under the overall control of estrogen and progesterone...
  79. ncbi Estrogen-mediated endothelial progenitor cell biology and kinetics for physiological postnatal vasculogenesis
    Haruchika Masuda
    Department of Regenerative Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Circ Res 101:598-606. 2007
    ..These findings demonstrate that physiological postnatal vasculogenesis involves cyclic, E2-regulated bioactivity of BM-derived EPCs, predominantly through the ER alpha...
  80. pmc Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium
    Elena Burova
    Department of Intracellular Signaling and Transport, Institute of Cytology of Russian Academy of Sciences, St Petersburg 194064, Russia
    Oxid Med Cell Longev 2013:474931. 2013
    ..The responses of human endometrium-derived mesenchymal stem cells (hMESCs) to oxidative stress remain still unknown...
  81. pmc Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility
    Shan Herath
    Institute of Life Science, School of Medicine, Swansea University, Singleton Park, Swansea, SA2 8PP, UK
    Reprod Biol Endocrinol 7:55. 2009
    ..The present study tested the hypothesis that postpartum cattle that develop persistent endometritis and infertility are unable to limit the inflammatory response to uterine bacterial infection...
  82. ncbi Coordinate regulation of heterogeneous nuclear ribonucleoprotein dynamics by steroid hormones in the human fallopian tube and endometrium in vivo and in vitro
    Ruijin Shao
    Dept of Physiology Endocrinology, Sahlgrenska Academy, Univ of Gothenburg, Box 434, Gothenburg, Sweden
    Am J Physiol Endocrinol Metab 302:E1269-82. 2012
    ..to date, the regulation of hnRNPs and their interactions with steroid hormone signaling in fallopian tubes and endometrium are not fully elucidated...
  83. pmc Augmented cell survival in eutopic endometrium from women with endometriosis: expression of c-myc, TGF-beta1 and bax genes
    M Cecilia Johnson
    Institute of Maternal and Child Research, School of Medicine, University of Chile, San Borja Arriaran Clinical Hospital, Santiago, Chile
    Reprod Biol Endocrinol 3:45. 2005
    ..aim of this study was to evaluate if the balance between cell proliferation and apoptosis is changed in eutopic endometrium from women with endometriosis throughout the menstrual cycle by studying bax (pro-apoptotic), c-myc (regulator ..
  84. ncbi Regulation of matrix metalloproteinases activity studied in human endometrium as a paradigm of cyclic tissue breakdown and regeneration
    Héloïse P Gaide Chevronnay
    Cell Biology Unit, de Duve Institute, Universite Catholique de Louvain, Bruxelles, Belgium
    Biochim Biophys Acta 1824:146-56. 2012
    ..The resulting massive tissue breakdown is best exemplified in humans by the menstrual lysis and shedding of the endometrium, the mucosa lining the uterus...
  85. ncbi Paracrine regulation of endometriotic tissue
    Francesca Minici
    Cattedra di Fisiopatologia della Riproduzione Umana, Universita Cattolica del Sacro Cuore, Rome, Italy
    Gynecol Endocrinol 23:574-80. 2007
    ..Since the peculiar biological characteristics of eutopic endometrium from women with endometriosis differ from endometrium of normal subjects, an important role in the pathogenesis ..
  86. ncbi Decidual HtrA3 negatively regulates trophoblast invasion during human placentation
    Harmeet Singh
    Prince Henry s Institute of Medical Research, PO Box 5152, 246 Clayton Road, Clayton, VIC 3168, Australia
    Hum Reprod 26:748-57. 2011
    ..001). CONCLUSIONS These results strongly support the hypothesis that decidual HtrA3 negatively regulates trophoblast invasion...
  87. ncbi Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis
    I Y Yotova
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Hum Reprod 26:885-97. 2011
    ..The differences in cell proliferation and migration between both cell types are likely due to increased activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in cells from endometriosis patients...
  88. ncbi The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells
    Yue Jiang
    Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, PR China
    Biochem Biophys Res Commun 404:628-33. 2011
    ..01) induced by 8-Br-cAMP and MPA. These results demonstrate that Nur77 is a novel transcription factor that contributes significantly to the regulation of prolactin gene expression in human endometrial stromal cells...
  89. ncbi Tyrosine receptor kinase B (TrkB) protein expression in the human endometrium
    Dana L Anger
    Reproductive Biology Division, Department of Obstetrics and Gynecology, HSC 3N52D, McMaster University, 1200 Main Street W, Hamilton, ON, Canada
    Endocrine 31:167-73. 2007
    ..However, TrkB protein expression in the eutopic endometrium of women with and without endometriosis is unknown...
  90. ncbi Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas
    Seetharaman Balasenthil
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 37:656-61. 2006
    ..We investigated the expression profile of MTA1 in different stages of benign endometrium as well as in endometrial endometrioid adenocarcinoma using immunohistochemistry and Western blotting...
  91. ncbi Effect of tumour necrosis factor-α in combination with interferon-γ on first trimester extravillous trophoblast invasion
    Harry A Otun
    Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE24HH, UK
    J Reprod Immunol 88:1-11. 2011
    ..The mode of activity of TNF-α was modified by the presence of IFN-γ, suggesting that the local cytokine milieu may be critical in determining spatial and/or temporal changes in EVT invasion...
  92. pmc The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review
    Alysson Zanatta
    Huntington Medicina Reprodutiva, Av República do Líbano, 529 Ibirapuera, 04501 000 São Paulo, SP, Brazil
    J Assist Reprod Genet 27:701-10. 2010
    ..This could in turn elucidate how various clinical and surgical treatments might affect the evolution and remission of the disease...
  93. ncbi Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells
    Gaurang S Daftary
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Endocrinol 16:571-9. 2002
    Estrogen and progesterone regulate HOXA10 expression in the endometrium, where HOXA10 is necessary for implantation. The integrins are also involved in early embryo-endometrial interactions...
  94. ncbi Effect of conceptus secretions on HOXA10 and PTGS2 gene expression, and PGE2 release in co-cultured luminal epithelial and stromal cells of the porcine endometrium at the time of early implantation
    A Blitek
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 76:954-66. 2011
    Homeobox A10 (HOXA10) gene expression was demonstrated in the endometrium of adult porcine uteri, however there is little information concerning the role of this gene in the pig...
  95. ncbi Role of TGF-betas in normal human endometrium and endometriosis
    Charles O A Omwandho
    Department of Biochemistry, University of Nairobi, Nairobi, Kenya
    Hum Reprod 25:101-9. 2010
    ..TGF-betas are abundantly and differentially expressed in the endometrium under hormonal control...
  96. pmc Ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast
    W Colin Duncan
    MRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, Midlothian, United Kingdom
    PLoS ONE 6:e23595. 2011
    The endometrium in early pregnancy undergoes decidualization and functional changes induced by local trophoblast, which are not fully understood...
  97. ncbi Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology
    Anne Riesewijk
    NV Organon, Department of Target Discovery, Oss, The Netherlands
    Mol Hum Reprod 9:253-64. 2003
    In humans, embryonic implantation and reproduction depends on the interaction of the embryo with the receptive endometrium. To gain a global molecular understanding of human endometrial receptivity, we compared gene expression profiles ..
  98. ncbi Regulation of prostaglandin biosynthesis by interleukin-1 in cultured bovine endometrial cells
    Michiyo Tanikawa
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    J Endocrinol 199:425-34. 2008
    Interleukin-1 (IL1) has been shown to be a potent stimulator of prostaglandin (PG) production in bovine endometrium. The aim of the present study was to determine the cell types in the endometrium (epithelial or stromal cells) ..
  99. pmc Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium
    Sanaz Memarzadeh
    Department of Obstetrics and Gynecology, The David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:17298-303. 2010
    ..Regenerated endometrial glands responded to pharmacologic variations in hormonal milieu similar to the native endometrium. Cell-autonomous activation of the PI3-kinase pathway via biallelic loss of PTEN or activation of AKT in adult ..
  100. ncbi The postimplantation embryo differentially regulates endometrial gene expression and decidualization
    Aki Kashiwagi
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, Thier Research Building, Room 931, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Endocrinology 148:4173-84. 2007
    Transcriptomal changes in the uterine endometrium induced in response to the implanting embryo remain largely unknown...
  101. ncbi Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival...

Research Grants69

  1. Biotransformation of Estrogens to Carcinogenic Quinoids
    JUDY BOLTON; Fiscal Year: 2005
    ..between excessive exposure to estrogens and the development of cancer in several tissues including breast and endometrium. The risk factors for women developing these cancers are all associated with longer estrogen exposure; early ..
  2. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..at higher risk than the general population of developing cancer of the urinary tract, liver, pancreas, colon, endometrium and kidney...
  3. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..mucosal pathogen, infecting only the superficial epithelial layer of the genital tract, including the cervix, endometrium, and oviduct...
  4. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..Each year more than 5.8 million patients are diagnosed with cancers of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and testis, for which first-..
  5. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    ..condition significantly increases risk for cancers of the colon, liver, pancreas, kidney, breast, cervix, and endometrium;however, the mechanisms responsible remain unknown...
  6. Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red c
    BIRGIT MARIA DIETZ; Fiscal Year: 2010
    ..of this project is that black cohosh and red clover reduce the carcinogenic effects of tamoxifen on the endometrium by inhibition of cell proliferation (Aim I) and through enhancing detoxification pathways (Aim 2)...
  7. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..Expression of this receptor is highly elevated in ectopic endometrial implants when compared to normal endometrium, and overexpression of this orphan receptor is strongly implicated as a driver of local estrogen biosynthesis...
  8. The Role of The Histone Epigenome in the Pathophysiology of Endometriosis
    MARICARMEN COLON; Fiscal Year: 2012
    ..isoforms belonging to the HDAC Class I family were higher in an endometriotic cell line as compared to normal endometrium cell lines...
  9. MSM Mapping and Modeling ErbB Receptor Membrane Topogra
    Bridget S Wilson; Fiscal Year: 2012
    ..Public Health Relevance. This project targets two women's cancer, breast and endometrium, and the ErbB family of receptors...
  10. Effect of Insulin on Estrogen Receptor Alpha Activity in Human Endometrial Cells
    CLARE ANN FLANNERY; Fiscal Year: 2013
    ..Robert Sherwin. She will acquire more experience in molecular biology to apply to her project on the endometrium, as well as improving her knowledge in the design, conduct, and analysis of clinical research...
  11. GHSU/WSU Cooperative Reproductive Medicine Network
    Michael Peter Diamond; Fiscal Year: 2013
    ..such women;and 3) Determine the influence of progestin withdrawal on the luteal phase hormonal milieu and the endometrium. The expected outcome is that renewal of our membership in the Network would allow continued contribution to ..
  12. Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
    Teresa K Woodruff; Fiscal Year: 2013
    ..individual follicles (that enclose and support oocytes), oviductal/fallopian tubes, uterine myometrium and endometrium, the cervix and the vagina...
  13. Biosignature of the endometrium in women with endometriosis
    Neil Sidell; Fiscal Year: 2010
    ..of Gynecology and Obstetrics, Emory University School of Medicine, we hope to identify a biosignature of the endometrium of endometriosis patients that will provide a low cost, simplified surgical alternative for the diagnosis of ..
  14. Follicular and endometrial pathology in polycystic ovary syndrome
    ANNE ELIZABETH NEWELL-FUGATE; Fiscal Year: 2011
    ..aberrations which lead to hyperandrogenemia and the interrelationship between hyperandrogenemia and the endometrium in the obese Ossabaw pig model of PCOS...
  15. Hormone-Regulated Pathways Controlling Implantation and Fertility
    Milan K Bagchi; Fiscal Year: 2012
    ..Failure of the fertilized embryo to implant into the endometrium is a major cause of infertility...
  16. Role of estrogen receptor in endometrial cancer initiation and progression
    Sanaz Memarzadeh; Fiscal Year: 2013
    ..While ER 1 and ER 2 are both expressed in the endometrium, based on functional studies ER 1 - the main focus of the outlined studies in this grant - is thought to be the ..
  17. The Role of Fbxw7 in genetic instability and cancer
    Jian Hua Mao; Fiscal Year: 2012
    ..in cancers from a wide spectrum of human tissues, such as bile duct, blood, bone, brain, breast, colon, endometrium, stomach, lung, ovary, pancreas, and prostate...
  18. Weight Loss &Cancer Biomarkers in Women: 0xidative Stress &Inflammation
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..and sedentary lifestyles are associated with an increased risk for several cancers in women, including colon, endometrium, postmenopausal breast, kidney, and lower esophageal cancer...
  19. Extranuclear estrogen receptor actions on endometrial cancer cell proliferation
    Twila A Jackson; Fiscal Year: 2012
    ..Estrogen (through the estrogen receptor) provides the primary proliferative signal in the endometrium and controls critical cellular processes such as proliferation and differentiation in many tissues including ..
  20. Quantification of Immune Cells in Women Using Contraception
    SHARON LYNELLE ACHILLES; Fiscal Year: 2013
    ..Cells from each participant will be collected from the cervix (using both cytobrush and biopsy), the endometrium, and peripheral blood at baseline (in the early follicular phase of their menstrual cycle) and after 3 and 6 ..
  21. Progesterone Action in the Endometrium of Women with Endometriosis
    Steven L Young; Fiscal Year: 2013
    ..We and others have demonstrated abnormal expression of genes regulated by progesterone (P) in eutopic endometrium of women with endometriosis, suggesting resistance to P...
  22. MECHANISM OF ACTION OF ANTITUMOR DRUGS
    Leroy F Liu; Fiscal Year: 2013
    ..ISG15 is highly elevated in many types of tumors, but absent in normal cells (except endometrium during early pregnancy)...
  23. Steroid Hormone Regulation of Uterine Function and Dysfunction
    Jae Wook Jeong; Fiscal Year: 2012
    ..The expression of Mig-6 in both level and cell specificity is dependent upon the menstrual cycle in the human endometrium. The expression of Mig- 6 is decreased in human endometriosis and endometrial cancer patients...
  24. Modulation of the Receptive Endometrium by CG
    Asgerally T Fazleabas; Fiscal Year: 2013
    ..We believe a better understanding of the molecular mechanisms responsible for decidualization and implantation will improve clinician's ability to detect, diagnose and treat early pregnancy loss. ..
  25. Environmental Estrogen Induced Epigenetic Alteration of Uterine Stem Cells
    Hugh S Taylor; Fiscal Year: 2013
    ..shown that fetal exposure to these agents alters the methylation of estrogen response elements (EREs) in the endometrium. The change in ERE methylation results in altered ERE occupancy by estrogen receptor (ER) in vivo and altered ..
  26. Center for Endometrial Biology and Endometriosis
    Hugh S Taylor; Fiscal Year: 2011
    ..Disorders of the endometrium and endometriosis result in significant morbidity including infertility, abnormal uterine bleeding, pelvic pain ..
  27. Molecular mechanism of LPA3-mediated uterine receptivity
    Xiaoqin Ye; Fiscal Year: 2013
    ..provided by applicant): Defective uterine receptivity, including delayed uterine receptivity and non-receptive endometrium, is the key maternal factor for infertility and early pregnancy loss...
  28. Endometriosis and Retinoids
    Serdar E Bulun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endometriosis, the pathologic endometrium-like tissue on pelvic organs, develops and persists in part due to defective apoptosis and is associated with pelvic pain and infertility...
  29. Follicular and endometrial pathology in polycystic ovary syndrome
    ANNE ELIZABETH NEWELL-FUGATE; Fiscal Year: 2013
    ..aberrations which lead to hyperandrogenemia and the interrelationship between hyperandrogenemia and the endometrium in the obese Ossabaw pig model of PCOS...
  30. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..provided by applicant): Endometriosis is an inflammatory disease characterized by the presence of functional endometrium outside the uterine cavity. The major two symptoms are intolerable pelvic pain and infertility...
  31. Origins and Biological Consequences of Human Infertility
    Linda C Giudice; Fiscal Year: 2013
    ..regulation of trophoblast differentiation;Projec IV (Linda Giudice) will investigate development of human endometrium for embryonic implantation;and the Pilot Project (NamTran) proposes to investigate molecular mechanisms ..
  32. Endocrine disruption of myometrial stem cell activities
    JOSE M TEIXEIRA; Fiscal Year: 2013
    ..the molecular mechanisms involved are largely unknown, particularly in primates where the top layer of the endometrium is shed and regenerated every month...
  33. Progestin Effects on Uterine Hemostatis &Angiogenesis
    Charles Lockwood; Fiscal Year: 2011
    ..Moreover, a model will be established to test innovative LTPOC formulations that minimize uterine and endometrial vasoconstriction and ROS-generation, thus preventing abnormal bleeding to improve the acceptability of LTPOC therapies. ..
  34. A macaque model for endometriosis induced pelvic pain and infertility
    Ov D Slayden; Fiscal Year: 2013
    ..Several studies have created ectopic endometrium in macaques, those studies failed to yield a reliable endometriosis model...
  35. Mouse Model of Endometrial Tumorigenesis
    Lora Hedrick Ellenson; Fiscal Year: 2013
    ..Furthermore, estrogen and its primary receptor in the endometrium, ER, stimulate endometrial proliferation via activation of the PI3K/AKT/PTEN pathway...
  36. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..electrophysiological methods are proposed to determine the characteristics of the effect of uterus, endometrium, and myometrium on the sciatic nerve. First, the proportion of through-conducting axons will be determined...
  37. The Role of the CXCR4/CXCL12 axis in endometriosis
    ABIGAIL RUIZ-RIVERA; Fiscal Year: 2013
    ..The two main cellular components of the endometrium, namely epithelial (EEC) and stromal (HESC) cells, show a differential expression of CXCR4 and CXCL12 proteins: ..
  38. Uterine Vascular Remodeling during Pregnancy
    James K Pru; Fiscal Year: 2013
    ..generates active hemodynamic peptides through proteolytic cleavage of angiotensinogen, is up-regulated in the endometrium during early gestation...
  39. Metformin as a Novel Chemotheraeutic Strategy for the Treatment of Endometrial Ca
    VICTORIA LIN BAE-JUMP; Fiscal Year: 2013
    ..Lastly, I will determine the effect of metformin on the endometrium of obese and diabetic women with endometrial cancer by comparing each patient's endometrial biopsy with ..
  40. Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits
    REGINE SITRUK WARE; Fiscal Year: 2013
    ..SA2: A contraceptive intrauterine system (IDS) releasing low doses of UPA to decrease endometrium and bleeding will be developed SA3: Molecular mechanisms underlying potential benefits of UPA CVR will be ..
  41. System biology approach to understand endometrial receptivity &pregnancy loss
    Thomas E Spencer; Fiscal Year: 2013
    ..The receptive endometrium represents a temporary, but unique physiological state of the uterus when conceptus (embryo and associated ..
  42. Molecular Basis of Treating Endometriosis by Prostaglandin E2 Receptor Inhibitors
    Joe A Arosh; Fiscal Year: 2012
    ..This is a R21 application addresses the mission of NIH/NICHD on women's reproductive health. ..
  43. Global methylation profile in endometrium of endometriosis patients
    Susan C Nagel; Fiscal Year: 2012
    ..of altered DNA methylation of specific genes and increased expression of DNA methyltransferases in patient endometrium. However, to date a global analysis of the DNA methylation status of endometrial tissue is lacking...
  44. MOLECULAR DETERMINANTS OF ANDROGEN RECEPTOR FUNCTION
    Elizabeth M Wilson; Fiscal Year: 2011
    ..Our hypothesis is that MAGE-n modulates AR activity in human ovary and endometrium by facilitating the recruitment of coregulators to the AR transcription complex through direct and indirect ..
  45. ASPECTS OF BLASTOCYST IMPLANTATION
    Sudhansu K Dey; Fiscal Year: 2010
    ..This research is clinically relevant because Msx1 is downregulated in the human endometrium during the receptive phase (window of implantation)...
  46. Microbial Exposures across the Lifespan and Cancer Risk in Women
    Christina A Clarke; Fiscal Year: 2011
    ..that together account for a large proportion of the cancer burden in US women, including cancers of the breast, endometrium, colon, thyroid, and melanocyte...
  47. KEEPS Cognitive and Affective Study
    Sanjay Asthana; Fiscal Year: 2013
    ..will employ cyclic administration of micronized progesterone to counteract proliferative effects of HT on the endometrium, and accomplish the following objectives: 1) to characterize the potential differential efficacy and adverse ..
  48. Comparative Risk of Endometrial Cancer from Ablation Versus Medical Management
    BRIAN LESLIE STROM; Fiscal Year: 2012
    ..It is designed to study differences in cancer of the womb (endometrium) by comparing the risk of cancer, the delay in diagnosis of cancer, and the severity of each cancer between ..
  49. Influence of AKT pathway on progesterone receptor function in endometrial cancer
    JI YONG JULIE KIM; Fiscal Year: 2013
    ..therapy has been shown to be effective in preventing endometrial cancer as well as controlling growth of the endometrium. However, the effectiveness of progestins for women with endometrial cancer is less clear...
  50. Mentoring and Research in Mouse Models of Cancer and Infertility
    Diego H Castrillon; Fiscal Year: 2011
    ..endometrial cancer, we will develop a heterotopic transplantation model of genetically-modified Lkb1-deficient endometrium. These studies will result in mouse models that will be useful to 1) identify and perform detailed analyses of ..
  51. Biophotonics Noninvasive Detection of Ovarian Cancer
    Hemant K Roy; Fiscal Year: 2012
    ..cancer screening strategy based on identifying ovarian field cancerization at a clinically practical site (endometrium or cervix) through our novel biophotonics approach analogous with our successful programs in the colon, lung ..
  52. Role of Autophagy in the Pathogenesis of Endometriosis
    Meera Nanjundan; Fiscal Year: 2013
    ..are unclear;thus, and a better understanding of the underlying molecular changes that occur in the endometrium is needed to improve current therapeutic strategies and the reproductive capacity for these patients...
  53. Trans-splicing of RNA in Endometrail Stroma and Other Tissues
    Jeffrey Sklar; Fiscal Year: 2013
    ..Additional evidence suggests that in the normal endometrium trans-splicing between the pre- mRNAs is physiologically regulated, but in the tumors the gene fusion produces ..
  54. HISTOMETRIC ANALYSIS OF PREMALIGNANT ENDOMETRIAL LESIONS
    Francisco Garcia; Fiscal Year: 2003
    Adenocarcinoma of the endometrium is the most common gynecologic malignancy in the United States. It accounts for about 36,000 cases of invasive cancer each year and is among the top five neoplasms affecting women...
  55. Dissecting the functional role of miRNAs in decidualization
    Warren B Nothnick; Fiscal Year: 2013
    ..Recently, miRNA mis-expression in endometrium from women who suffer from repeated implantation failure has been documented (Revel et al., 2011)...
  56. SURGICAL TREATMENTS OUTCOMES PROJECT FOR DUB (STOP-DUB)
    Kay Dickersin; Fiscal Year: 2000
    ..The baseline exam will include physical exam and either ultrasound or hysteroscopic evaluation of the endometrium. A log of patients refusing consent will be maintained for comparison with those who proceed with the study...
  57. The pharmacological actions of antiprogestins in uterine fibroids
    Donald P McDonnell; Fiscal Year: 2010
    ..will lead to development and validation of new approaches with which to identify novel antiprogestins/SPRMs that effectively treat fibroids but which do not manifest abnormal pathological responses in the endometrium.
  58. ENDOMETRIAL VEGF: ENDOCRINE REGULATION OF ANGIOGENESIS
    Robert Taylor; Fiscal Year: 1999
    ..that a specific angiogenic peptide, vascular endothelial growth factor (VEGF), is hormonally regulated in human endometrium. We hypothesize that VEGF mediates the effects of ovarian steroids on the growth and function of the ..
  59. MECHANISMS OF INFERTILITY IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    ..of 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD-2) in endometriosis (in comparison with the eutopic endometrium) give rise to elevated local levels of estradiol, which is mitogenic for endometriotic tissue...
  60. PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSIS
    CECIL LYTTLE; Fiscal Year: 1993
    ..However, in patients with endometriosis the proliferative phase endometrium demonstrates high chemotactic activity...
  61. Hyaluronan/CD44 and the Early Endometriotic Lesion
    Robert Schenken; Fiscal Year: 2005
    ..One theory, known as Sampson's theory, proposes that fragments of menstrual endometrium pass retrograde through the fallopian tubes into the peritoneal cavity where they attach and grow on peritoneal ..
  62. UTERINE BIOLOGY AND THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS
    Kevin Osteen; Fiscal Year: 2003
    ..Most cases of endometriosis can be attributed to ectopic implantation of fragments of endometrium entering the peritoneal cavity following reflex menstruation...
  63. Cytochrome-P-450 genes in pathobiology of endometrial cancer
    Rajvir Dahiya; Fiscal Year: 2009
    ..We hypothesize that the CYP1A1 and CYP1B1 genes are hyper-activated during malignant transformation of the endometrium. To test this hypothesis, we will: (a) Analyze the level of CYP1A1 and CYP1B1 mRNA expression by real-time PCR (..
  64. ANTIPROGESTINS IN ENDOMETRIUM
    RONALD WIEHLE; Fiscal Year: 2000
    ..Tissues of the reproductive system such as pituitary, breast, myometrium, cervix, and endometrium remain obvious target organs for treatment with APs...
  65. Antiprogestins in Cynomolgus Endometriosis
    RONALD WIEHLE; Fiscal Year: 2003
    ..Tissues of the reproductive system such as pituitary, breast, myometrium, cervix, and endometrium remain obvious target organs for treatment...
  66. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ..One theory, known as Sampson's theory, proposes that fragments of menstrual endometrium pass retrograde through the fallopian tubes into the peritoneal cavity where they attach and grow on peritoneal ..
  67. Tumor Suppressor Role of ARID1A
    Ie Ming Shih; Fiscal Year: 2013
    ..The main objective of this study is to demonstrate the tumor suppressor role of ARID1A in the pathogenesis of endometrium-related cancer...
  68. Primate Endometrial Responses to Placental MHC Class I Molecules
    Thaddeus Golos; Fiscal Year: 2009
    ..and T cells, the modification of smooth muscle in maternal vessels, and differentiation in the functional endometrium. To begin to address this hypothesis, we will evaluate soluble Mamu-AG expression and define its effects on ..
  69. Chemoprevention of Uterine Cancer Risk by Antioxidants
    Minoti Sharma; Fiscal Year: 2003
    ..Expression of CYPs in human uterine endometrium suggests that endometrial tissue has potential to generate genotoxic Tam metabolites...