Genomes and Genes
Summary: The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
Publications219 found, 100 shown here
- Mucin genes expressed by human female reproductive tract epitheliaI K Gipson
Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Reprod 56:999-1011. 1997....
- Human immunodeficiency virus type 1 genomic RNA sequences in the female genital tract and blood: compartmentalization and intrapatient recombinationSean Philpott
Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
J Virol 79:353-63. 2005....
- Coevolution of male and female genital morphology in waterfowlPatricia L R Brennan
Department of Ecology and Evolutionary Biology, and Peabody Natural History Museum, Yale University, New Haven, Connecticut, United States of America
PLoS ONE 2:e418. 2007..Our results suggest that females have evolved a cryptic anatomical mechanism of choice in response to forced extra-pair copulations...
- Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selectionWillie J Swanson
Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
Genetics 168:1457-65. 2004....
- Characterization of the external female genitalia of six species of Triatominae (Hemiptera: Reduviidade) by scanning electron microscopyJoão Aristeu da Rosa
Departamento de Ciencias Biologicas, Universidade Estadual Paulista Araraquara, Araraquara, SP, Brasil
Mem Inst Oswaldo Cruz 105:286-92. 2010..Scanning observation of the dorsal, ventral, lateral and posterior sides of the female genitalia of Panstrongylus herreri, Panstrongylus megistus, Rhodnius colombiensis, Rhodnius prolixus, Triatoma ..
- Unlocking the "Black box": internal female genitalia in Sepsidae (Diptera) evolve fast and are species-specificNalini Puniamoorthy
Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
BMC Evol Biol 10:275. 2010..The internal female genitalia, in sharp contrast, remain poorly studied...
- Sperm-female coevolution in DrosophilaGary T Miller
Department of Biology, Syracuse University, 108 College Place, Syracuse, NY 13244, USA
Science 298:1230-3. 2002..Giant sperm tails are the cellular equivalent of the peacock's tail, having evolved because females evolved reproductive tracts that selectively bias paternity in favor of males with longer sperm...
- Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatmentA Wald
Department of Medicine, University of Washington, Seattle 98195, USA
J Clin Invest 99:1092-7. 1997..HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide...
- MUC1/episialin: a critical barrier in the female reproductive tractM M DeSouza
Department of Biological Sciences, University of Delaware, Newark 19716 2590, USA
J Reprod Immunol 45:127-58. 1999..Collectively, these studies demonstrate a critical barrier role for Muc1 in various aspects of female reproductive tract physiology...
- Anogenital distance in human male and female newborns: a descriptive, cross-sectional studyEduardo Salazar-Martinez
National Institute of Public Health, Av Universidad 655, Col Santa Ma Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
Environ Health 3:8. 2004..Because AGD has been an easy-to-measure, sensitive outcome in animals studies, we developed and implemented an anthropometric protocol for measurement of AGD in human males as well as females...
- Resolving mechanisms of competitive fertilization success in Drosophila melanogasterMollie K Manier
Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
Science 328:354-7. 2010..We find that competitive male fertilization success derives from a multivariate process involving ejaculate-female and ejaculate-ejaculate interactions, as well as complex sperm behavior in vivo...
- The impact of endocrine disrupters on the female reproductive systemP Nicolopoulou-Stamati
Department of Pathology, Medical School, University of Athens, Greece
Hum Reprod Update 7:323-30. 2001..The aim is to present available information, highlighting the impact of endocrine disrupters on the female reproductive system, in order to stimulate reevaluation in identifying hormone disorders...
- Localization of the Drosophila male accessory gland protein Acp36DE in the mated female suggests a role in sperm storageM J Bertram
Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
Insect Biochem Mol Biol 26:971-80. 1996..Facilitation of sperm storage by Acp36DE may also explain the previously observed effect of this protein on sperm competition...
- Expression and steroid hormonal control of Muc-1 in the mouse uterusG A Surveyor
Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
Endocrinology 136:3639-47. 1995..Collectively, these data indicate that Muc-1 expression in mouse uterine epithelium is strongly influenced by ovarian steroids. It is suggested that the loss of Muc-1 contributes to generation of a receptive uterine state...
- Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tractPatricia A Pioli
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Infect Immun 72:5799-806. 2004..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
- Multiple pyogenic granuloma involving female genitalia: a rare entity?Tejinder Kaur
Pediatr Dermatol 21:614-5. 2004
- Alteration of glutathione reductase expression in the female reproductive organs during the estrous cycleT Kaneko
Department of Biochemistry, Yamagata University School of Medicine, Yamagata, Yamagata 990-9585, Japan
Biol Reprod 65:1410-6. 2001..Because GSH is known to increase gamete viability and the efficiency of fertility, GR, which is expressed in these tissues, is predicted to play a pivotal role in the reproduction process as a source of GSH...
- Silhouettella loricatula (Arachnida, Araneae, Oonopidae): a Haplogyne spider with complex female genitaliaMatthias Burger
Natural History Museum, Department of Invertebrates, CH 3005 Bern, Switzerland
J Morphol 267:663-77. 2006..The microorganisms can be identified partly as bacteria. They are enclosed in secretion and are always found in the same position inside the receptaculum...
- The anatomy of fertilization in the yellow dung fly Scathophaga stercorariaB I Arthur
Zoological Museum, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich
J Morphol 269:630-7. 2008..Such anatomy potentially gives the female a large degree of control over sperm traffic from storage to the site of fertilization...
- Nonantagonistic interactions between the sexes revealed by the ecological consequences of reproductive traitsL Lacey Knowles
Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109 1079, USA
J Evol Biol 18:156-61. 2005....
- Determinants of HIV-1 shedding in the genital tract of womenA Kovacs
Maternal Child and Adolescent HIV Management and Research Center, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
Lancet 358:1593-601. 2001..We aimed to assess the relation between HIV-1 shedding (RNA or culturable virus) in female genital secretions and other factors that might affect HIV-1 shedding...
- Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspringYasuyoshi Nikaido
Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
Reprod Toxicol 18:803-11. 2004..High-dose GEN and RES and high- and low-dose BPA and DES exerted transient effects on the reproductive tract and mammary glands, whereas ZEA exerted prolonged effects...
- Pathobiology of triple reassortant H3N2 influenza viruses in breeder turkeys and its potential implication for vaccine studies in turkeysS P S Pillai
Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
Vaccine 27:819-24. 2009....
- Female genitalia concealment promotes intimate male courtship in a water striderChang S Han
Laboratory of Behavioral Ecology and Evolution, School of Biological Sciences, Seoul National University, Seoul, South Korea
PLoS ONE 4:e5793. 2009..Our results indicate that the apparent victory of coevolutionary arms race by one sex in terms of morphology may trigger evolution of a behavioral phenotype in the opposite sex...
- HIV-1 drug resistance in variants from the female genital tract and plasmaKimdar Sherefa Kemal
Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
J Infect Dis 195:535-45. 2007..Human immunodeficiency virus type 1 (HIV-1) drug-resistance mutations may arise in a fraction of viral variants, and these variants may differ between compartments, including the genital tract and blood...
- Function of multiple sperm storage organs in female Mediterranean fruit flies (Ceratitis capitata, Diptera: Tephritidae)Eyal Twig
Department of Entomology, Hebrew University of Jerusalem, POB 12, Rehovot 76100, Israel
J Insect Physiol 51:67-74. 2005..We suggest that the use of both organs by females results in sperm economy, which adaptively prolongs the intervals between copulations...
- NK cell function in the human female reproductive tractCharles L Sentman
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Reprod Immunol 57:108-15. 2007..Uterine NK cells have a unique phenotype compared with blood NK cell subsets, yet little is known about how NK cells function as a part of the innate immune cell network in the female reproductive tract...
- Copulation behaviour of Glossina pallidipes (Diptera: Muscidae) outside and inside the female, with a discussion of genitalic evolutionR D Briceño
Escuela de Biologia, Universidad de Costa Rica, Ciudad Universitaria, Costa Rica
Bull Entomol Res 97:471-88. 2007..The elaborate copulatory courtship behaviour and male genitalia may provide the stimuli that previous studies showed to induce female ovulation and resistance to remating...
- HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant womenLisa M Frenkel
University of Washington, Seattle, Washington 98109, Children s Hospital and Medical Center of Seattle, Seattle, Washington 98105, USA
AIDS Res Hum Retroviruses 22:870-3. 2006..However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract...
- [The role of the physician when faced with mutilations of the female genitalia]Roger Henrion
Presse Med 32:1347-8. 2003
- HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylationKimdar Sherefa Kemal
New York State Department of Health, Wadsworth Center, 120 New Scotland Avenue, Albany, NY 12208, USA
Proc Natl Acad Sci U S A 100:12972-7. 2003..These findings are relevant to the prevention and control of HIV-1 infection...
- Anatomical studies of the female genitalia: surgical reconstructive implicationsLaurence S Baskin
Pediatric Urology, UCSF Children s Medical Center, University of California, Children s Hospital, San Francisco, CA 94143, USA
J Pediatr Endocrinol Metab 17:581-7. 2004..Herein, we review the neuroanatomy of the female genitalia and the implications for the rare patient who needs surgical reconstruction.
- Disruption of the female reproductive system by the phytoestrogen genisteinWendy N Jefferson
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
Reprod Toxicol 23:308-16. 2007..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood...
- Characterization of Toll-like receptors in the female reproductive tract in humansA Fazeli
Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, UK
Hum Reprod 20:1372-8. 2005....
- Male and female cooperate in the prohormone-like processing of a Drosophila melanogaster seminal fluid proteinM Park
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
Dev Biol 171:694-702. 1995..The need for molecular cooperation between the sexes for processing of Acp26Aa could restrict its activity to the mated female...
- Complex female genitalia indicate sperm dumping in armored goblin spiders (Arachnida, Araneae, Oonopidae)Matthias Burger
Division of Invertebrate Zoology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024, USA
Zoology (Jena) 113:19-32. 2010..Oonopidae are a diverse spider family comprising many species with peculiar female genitalia. Especially in species where studies of mating behavior are difficult, morphological investigations of the ..
- Meeting report: measuring endocrine-sensitive endpoints within the first years of lifeTye E Arbuckle
Biostatistics and Epidemiology Division, Health Canada, Ottawa, Ontario, Canada
Environ Health Perspect 116:948-51. 2008....
- Structure and function of the spermathecal complex in the phlebotomine sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae): I. ultrastructure and histologyK Ilango
Zoological Survey of India, Southern Regional Station, Chennai 600 028, India
J Biosci 30:711-31. 2005..Post-mating sexual selection may be responsible for the structural uniqueness of the spermathecal complex in phlebotomine sandflies...
- Structure and function of the spermathecal complex in the phlebotomine sandfly Phlebotomus papatasi Scopoli (Diptera: Psychodidae): II. post-copulatory histophysiological changes during the gonotrophic cycleK Ilango
Zoological Survey of India, Southern Regional Station, 130 Santhome High Road, Chennai 600 028, India
J Biosci 30:733-47. 2005..papatasi. As the females of P. papatasi mate polyandrously, the anatomical and physiological complexity of the spermathecal complex may be related to post-copulatory sexual selection...
- Hypospadias mimicking female genitalia on early second trimester sonographic examinationMarwan Odeh
Department of Obstetrics and Gynecology, Western Galilee Hospital, Rappaport Faculty of Medicine, Technion, Nahariya 22100, Haifa, Israel
J Clin Ultrasound 36:581-3. 2008..We therefore suggest that female fetal sex assignment should be based on the demonstration of the 2 or 4 parallel lines representing the labial folds and not only upon the demonstration of the downward direction of the genital tubercle...
- Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1Nicolas Chomont
Universite Paris V, Unité INSERM Internationale d Immunologie Humaine U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, and Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Paris, France
AIDS 21:153-62. 2007....
- Induction of gonadal toxicity to female rats after chronic exposure to mancozebP N Baligar
Post-graduate Department of Studies in Zoology, Karnatak University, Dharwad, India
Ind Health 39:235-43. 2001..These observed effect of mancozeb on the estrous cycle, follicles and biochemical constituents may be due to imbalance in the hormone or toxic effect...
- Colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the ratTomoko Kaneko
Department of Biochemistry, Yamagata University School of Medicine, 2 2 2 Iidanishi, 990 9585 Yamagata, Japan
Histochem Cell Biol 119:309-15. 2003..The abundance of AR compared with SDH suggests that it also plays an additional role in the reproductive system, which might include a source of reducing power and protection against toxic carbonyl compounds...
- Multigenerational exposure to phytosterols in the mouseAri Ryökkynen
Department of Biology, University of Joensuu, P O Box 111, FIN 80101, Joensuu, Finland
Reprod Toxicol 19:535-40. 2005..PS supplement also increased the testicular levels of testosterone in the male pups of F(2) generation. In spite of these transitory changes, PS exposure caused no permanent deleterious effects on the reproduction of the mouse...
- Reproductive tract infections in horsesKristina G Lu
Hagyard Equine Medical Institute, 4250 Iron Works Pike, Lexington, KY 40511, USA
Vet Clin North Am Equine Pract 22:519-52, x. 2006..Only then can a rational treatment plan be formulated. Many recent advances in knowledge about the reproductive system of multiple species have application to the mare and stallion...
- Multigeneration reproductive and developmental toxicity study of bar gene inserted into genetically modified potato on ratsGyu Seek Rhee
Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul
J Toxicol Environ Health A 68:2263-76. 2005..The results suggest that genetically modified crops have no adverse effects on the multigeneration reproductive-developmental ability...
- Angiotensin I-converting enzyme (ACE) activity of the tomato moth, Lacanobia oleracea: changes in levels of activity during development and after copulation suggest roles during metamorphosis and reproductionU V Ekbote
Molecular and Cellular Biosciences, Faculty of Biological Sciences, University of Leeds, LC Miall Building, Clarendon Way, Leeds LS2 9JT, UK
Insect Biochem Mol Biol 33:989-98. 2003..Evidence for such a proteolytic pathway and its role in providing substrates for the TCA cycle has been obtained previously in a study of reproduction in Bombyx mori...
- Developmental effects of ethinylestradiol on reproductive organs of female miceAkiko Kirigaya
Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa Ku, Yokohama 236 0027, Japan
In Vivo 20:867-73. 2006..Thus, it is clear that prenatal exposure to EE2 or DES induces reproductive abnormalities, including PF, ovary-independent vaginal epithelial stratification and cornification...
- Novelties of conception in insectivorous mammals (Lipotyphla), particularly shrewsJ Michael Bedford
Center for Reproductive Medicine and Infertility, Weill Medical College, Cornell University, New York, NY 10021, USA
Biol Rev Camb Philos Soc 79:891-909. 2004....
- Reproductive physiology of free-living White Ibises (Eudocimus albus) in the Florida EvergladesJulie A Heath
Department of Biology, Hofstra University, Hempstead, NY 11549, USA
Gen Comp Endocrinol 133:118-31. 2003..White Ibises showed similar patterns in reproductive physiology to other monogamous, seasonally breeding bird species in which both sexes incubate and care for the young...
- Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide microemulsionJack Y Zheng
Global Pharmaceutical R and D, Formulation Development Center, Abbott Laboratories, North Chicago, IL 60064 6246, USA
Int J Pharm 307:209-15. 2006..These findings suggest that systemic absorption of highly water-soluble protein or peptide drugs could be enhanced by oral microemulsions containing oleic acid...
- Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effectOsamu Takahashi
Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health, 24 1, Hyakunincho 3 chome, 169 0073 Shinjuku ku, Tokyo, Japan
Arch Toxicol 80:225-41. 2006..These results suggest that BM and TM are weakly toxic, possibly through an estrogenic mechanism to male reproductive organs in mice as well as rats, while MM and ME may be the direct testicular toxins in rats but not mice...
- Effect of exposure to high isoflavone-containing diets on prenatal and postnatal offspring miceKyoka Takashima-Sasaki
Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University
Biosci Biotechnol Biochem 70:2874-82. 2006..These results suggest that chronic exposure to higher than normal levels of IF induces alterations in the reproductive development of female mice through an estrogenic effect...
- Endogenous retroviruses and animal reproductionS Prudhomme
UMR 2142 CNRS bioMérieux, IFR 128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
Cytogenet Genome Res 110:353-64. 2005..We conclude with an insight on the evolutionary and epigenetic consequences of the relationships of ERV guests with their animal hosts...
- Reproductive morphology of Brittanichthys axelrodi (Teleostei: Characidae), a miniature inseminating fish from South AmericaRobert Javonillo
Department of Biological Sciences, The George Washington University, Washington, District of Columbia 20052, USA
J Morphol 268:23-32. 2007..These morphological features are likely linked to the reproductive mode of insemination, a trait that is so far as known, relatively rare among teleost fishes, but is proving increasingly frequent among certain groups of characid fishes...
- PELVIS SyndromeCéline Girard
Department of Dermatology, Hopital Saint Eloi, Centre Hospitalier Regional Universitaire, Montpellier, France
Arch Dermatol 142:884-8. 2006..Large perineal hemangiomas can be associated with congenital anomalies, including anorectal, urinary tract, spine, and external genitalia malformations...
- Xenoendocrine pollutants may reduce size of sexual organs in East Greenland polar bears (Ursus maritimus)Christian Sonne
Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, P O Box 358, DK 4000 Roskilde, Denmark
Environ Sci Technol 40:5668-74. 2006..This may pose a riskto this polar bear subpopulation in the future because of reduced sperm and egg quality/quantity and uterus and penis size/robustness...
- Effect of cigarette smoke on body weight, food intake and reproductive organs in adult albino ratsSumedha S Audi
Department of Physiology, Goa Medical College, Bambolim Goa, 403 202, India
Indian J Exp Biol 44:562-5. 2006..The number of sperms was less in the testes. The results show that exposure to cigarette smoke is detrimental to the reproductivity in both, male and female albino rats...
- Effect of gestational exposure to nonylphenol on the development and fertility of mouse offspringNaoko Kimura
Laboratory of Animal Reproduction, Faculty of Agricultural Science, Yamagata University, Tsuruoka, Japan
J Reprod Dev 52:789-95. 2006..9%) and NP1/10 (female: 9.8%) groups. These results suggest that exposure to NP in utero possibly affects the body weight and some reproductive organ weights, but does not influence the potential fertility of the F1 generation...
- Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive systemErdal Budak
Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain
Fertil Steril 85:1563-81. 2006....
- A synthetic gonadotropin-releasing hormone (GnRH) vaccine for control of fertility and hormone dependent diseases without any adjuvantXu Jinshu
The Minigene Pharmacy Laboratory, Biopharmaceutical College, China Pharmaceutical University, Tong Jia Xiang 24, Nanjing 210009 Jiangsu, PR China
Vaccine 23:4834-43. 2005....
- Effects of in utero and lactational exposure to tamoxifen in SD ratsKanji Yamasaki
Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
Toxicol Lett 156:289-96. 2005..6 and 3 microg/kg/day groups. No abnormalities were detected in the reproductive performance of the male and female offspring...
- Effects of butylated hydroxyanisole on the development and functions of reproductive system in ratsSang Hee Jeong
Toxicology Division, National Veterinary Research and Quarantine Service, 480, Anyang 430 016, Republic of Korea
Toxicology 208:49-62. 2005....
- Possible coevolution of male and female genital form and function in a calopterygid damselflyA Córdoba-Aguilar
Instituto de Ecologia, Universidad Nacional Autonoma de Mexico, Mexico, DF
J Evol Biol 18:132-7. 2005..A suggested coevolutionary interpretation of these results in C. haemorrhoidalis is that aedeagal width was favoured which was followed by a sensillum reduction...
- Effects of in utero and lactational exposure to di(2-ethylhexyl)phthalate on somatic and physical development in rat offspringKenichi Kobayashi
National Institute of Occupational Safety and Health, Nagao, Kawasaki, Japan
Ind Health 44:652-60. 2006....
- Functional morphology of the reproductive system of Galathea intermedia (Decapoda: Anomura)Katrin Kronenberger
Forschungsinstitut und Naturmuseum Senckenberg, 60325 Frankfurt am Main, Germany
J Morphol 262:500-16. 2004..No trace of a female reproductive system could be detected. Thus, these external intersexes are exclusively functional males...
- Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expressionG V Benson
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Development 122:2687-96. 1996..These results show that Hoxa-10 is required during morphogenesis for proper patterning of the reproductive tract and in the adult uterus for peri-implantation events...
- Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response studyCynthia J Wolf
Reproductive Toxicology Division, Endocrinology Branch, MD 72, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, 86 Alexander Drive, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 65:71-86. 2002..This study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities...
- Impairment of male rat reproductive function in F1 offspring from dams exposed to 2-bromopropane during gestation and lactationKyung Sun Kang
Department of Veterinary Public Health, College of Veterinary Medicine, School of Agricultural Biotechnology, Seoul National University, 103 Seodun dong, Kwonsun Gu, Suwon, 441 744, Korea
Reprod Toxicol 16:151-9. 2002..These results suggest that gestational and lactational exposure to 2-BP at a high maternally toxic dose impairs the development of the reproductive organs of the offspring...
- Decreased sperm number and motile activity on the F1 offspring maternally exposed to butyl p-hydroxybenzoic acid (butyl paraben)Kyung Sun Kang
Department of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea
J Vet Med Sci 64:227-35. 2002..Taken together, these results indicated that maternal exposure of BP might have adverse effects on the F1 male offspring...
- Humoral immune responses to microbial infections in the genital tractMichael W Russell
Department of Microbiology, and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, NY 14214, USA
Microbes Infect 4:667-77. 2002..Antibody responses to genital infections or to locally applied vaccines are usually modest, but alternative strategies for eliciting genital tract antibodies are being developed...
- Vaginal reconstruction for ambiguous genitalia and congenital absence of the vagina: a 27-year experienceKathleen Graziano
Section of Pediatric Surgery, Department of Surgery, the C S Mott Children s Hospital and the University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Pediatr Surg 37:955-60. 2002..Patients with an absent vagina require the construction of an artificial vagina. In an effort to improve care, the authors have categorized their experience with this group of children...
- A historical survey of scintigraphic methodology for evaluation of the reproductive tractL S Zuckier
Department of Radiology, Section of Nuclear Medicine, New Jersey Medical School, Newark, NJ, USA
Q J Nucl Med 46:160-8. 2002..Consideration of these methods will potentially stimulate future development and application of radionuclide techniques to emerging questions in the fields of reproductive and genital physiology...
- Mode of transfer of spermatozoa in Orthoptera TettigoniidaeRenata Viscuso
Dipartimento di Biologia Animale Marcello La Greca, Universita di Catania, Via Androne 81, 95124 Catania, Italy
Tissue Cell 34:337-48. 2002..As regards their role, it is hypothesized that these structures represent a long-term conservation mechanism for spermatozoa inside the seminal receptacle...
- A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicalsKazushi Okazaki
Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Arch Toxicol 76:553-9. 2002..However, the findings indicate that chemicals with weak endocrine-disrupting potential like genistein must be evaluated taking into consideration the results of other test systems...
- Experimental transmission of Trypanosoma cruzi through the genitalia of albino miceL Herrera
, , Facultad de Ciencias, Universidad Central de Venezuela, Caracas 104l-A, Venezuela
Mem Inst Oswaldo Cruz 96:713-7. 2001..cruzi with genital mucosa can produce blood and tissue infections. These results are discussed in relation to reports of frequent experimental tropism of T. cruzi toward urogenital organs...
- Ultrastructural evidence for secretion from the epithelium of ampulla ductus deferentis of the fan-throated lizard Sitana ponticeriana CuvierM A Akbarsha
Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India
J Morphol 266:94-111. 2005..It appears that within the Squamata, the ductal ampulla differs in structure as well as function. We suggest that the ductal ampulla of agamid lizards is a composite gland of the ampulla ductus deferentis and seminal vesicles of mammals...
- Reproductive isolation and morphogenetic evolution in Drosophila analyzed by breakage of ethological barriersL Sanchez
Centro de Investigaciones Biologicas, Velazquez, Madrid, Spain
Genetics 147:231-42. 1997..The effect on the terminalia of teissieri-melanogaster hybrids of a mutation in doublesex, a regulatory gene that controls the development of the terminalia, was also investigated...
- HOX-4 genes and the morphogenesis of mammalian genitaliaP Dolle
European Molecular Biology Laboratory, Heidelberg, Germany
Genes Dev 5:1767-7. 1991..We also show that genital tubercle mesenchyme can respecify pattern in the chicken wing bud. This finding reinforces the concept of the uniformity in the patterning mechanisms along the various axes of the body...
- Reproductive biology of the pampas deer (Ozotoceros bezoarticus): a reviewRodolfo Ungerfeld
Departamento de Fisiologia, Facultad de Veterinaria, Montevideo, Uruguay
Acta Vet Scand 50:16. 2008..Finally, an overview is given and future directions of research are proposed...
- Glycodelin mRNA is expressed in the genital tract of male and female rats (Rattus norvegicus)C Keil
Institute of Biochemistry, Ernst Moritz Arndt University, Klinikum, Sauerbruchstrasse, D 17487 Greifswald, Germany
J Mol Endocrinol 23:57-66. 1999..The expression in several reproductive organs of rats offers an excellent tool to study further the physiological role of glycodelin, which is so far thought to act as an immunosuppressive factor...
- Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 miceRachel L Ruhlen
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 116:322-8. 2008..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful...
- Genetic control of fertility and embryonic waste in the mouse: A rolefor angiotensinogenC B Tempfer
Department of Obstetrics and Gynecology and Department of Human and Molecular Genetics, Baylor Collegeof Medicine, Houston, Texas 77030, USA
Biol Reprod 62:457-62. 2000..001). We conclude that Agt deficiency is associated with an in utero lethal effect, decreased fertility, and impaired neonatal survival...
- Role of early GnRH administration in sexual behavior disorders of rat pups perinatally exposed to leadH S Spinosa
Department of Pathology, Faculty of Veterinary Medicine and Zootechny, , , Brazil
Neurotoxicol Teratol 23:203-12. 2001..These results show that perinatal exposure to Pb had a dose-dependent effect on the sexual behavior of rats and that a decrease in GnRH source in the offspring was probably involved in the reduction of their sexual performance...
- 1-Stage feminizing genitoplasty: 8 years of experience with 49 casesA Farkas
Department of Urology, Shaare Zedek Medical Center, Faculty of Health Science, Ben-Gurion University, Jerusalem, Israel
J Urol 165:2341-6. 2001..CONCLUSIONS: Our adapted technique of 1-stage feminizing genitoplasty provides good cosmetic and functional results. The functional results of this operation should be reevaluated after puberty and in adulthood...
- Effects of prenatal treatment with antiandrogens on luteinizing hormone secretion and sex steroid concentrations in adult spotted hyenas, Crocuta crocutaNed J Place
Department of Psychology, University of California, Berkeley, California 94720, USA
Biol Reprod 67:1405-13. 2002....
- Characteristics and fate of the spermatozoa of Inachus phalangium (Decapoda, Majidae): description of novel sperm structures and evidence for an additional mechanism of sperm competition in BrachyuraRocco Rorandelli
Dipartimento di Biologia Animale e Genetica Leo Pardi, University of Florence, 50125 Florence, Italy
J Morphol 269:259-71. 2008....
- Exposure to naturally circulating androgens during foetal life incurs direct reproductive costs in female spotted hyenas, but is prerequisite for male matingC M Drea
Department of Psychology, University of California at Berkeley, Berkeley, CA 94720, USA
Proc Biol Sci 269:1981-7. 2002..Moreover, the same androgens that render an extremely unusual and laborious process even more reproductively costly in the female are apparently essential to the male's physical ability to reproduce with a normally masculinized female...
- Handling during pregnancy in the blue fox (Alopex lagopus): the influence on the fetal gonadal functionLudmila V Osadchuk
Institute of Cytology and Genetics, Siberian Department of the Russian Academy of Sciences, Novosibirsk, 630090, Russia
Gen Comp Endocrinol 132:190-7. 2003..0.8+/-0.02 cm, P<0.01). These results indicate that prenatal stress resulted in a significant reduction of hormonal and morphometric measures of the reproductive system in blue fox fetuses with more drastic effects in female fetuses...
- Comparative performance of the Roche COBAS Amplicor assay and an in-house real-time PCR assay for diagnosis of Chlamydia trachomatis infectionHamid Jalal
Clinical Microbiology and Public Health Laboratory, Box 236, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QW, UK
J Med Microbiol 56:320-2. 2007..The sensitivity of IHRT-PCR was comparable with, and specificity was higher than, Amplicor PCR for the diagnosis of genital chlamydial infection...
- Clinical implications of rhinoceros reproductive tract anatomy and histologyN E Schaffer
SOS Rhino, 680 North Lake Shore Drive, Suite 807, Chicago, Illinois 60611, USA
J Zoo Wildl Med 32:31-46. 2001..Defining this unique morphology of rhinoceroses may help in understanding their reproductive physiology and will effect the development of appropriate reproductive techniques...
- Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 miceVendula Kyselova
Department of Biology and Biochemistry of Fertilization, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
Reprod Biol Endocrinol 1:30. 2003..The litter sex ratio was not different from controls. Unlike RES, NP had a negative effect on spermatogenesis and sperm quality with a resultant impact on in vivo fertility...
- Gross anatomy and ultrasonographic images of the reproductive system of the Sumatran rhinoceros (Dicerorhinus sumatrensis)Z Zainal Zahari
Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Anat Histol Embryol 31:350-4. 2002..Two lateral projections were located at the base of the penis. A well-defined process glandis was present at the tip of the penis. The accessory sex glands and the testes could be imaged by ultrasonography...
- Functions of platelet activating factor (PAF) in mammalian reproductive processes: a reviewW Kordan
University of Warmia and Mazury in Olsztyn, Faculty of Animal Bioengineering, Department of Animal Biochemistry and Biotechnology, 10 718 Olsztyn, Poland
Pol J Vet Sci 6:55-60. 2003..This review also addressed the importance of the mechanism regulating PAF metabolism, PAF-acetylhydrolase (PAF-AH), during the membrane fusion events associated with fertilization...
- Emerging roles for hedgehog-patched-Gli signal transduction in reproductionDavid O Walterhouse
Children s Memorial Hospital and the Children s Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Biol Reprod 69:8-14. 2003....
- [Congenital genital anomalies. Aspects of diagnostics and treatment]Indre Zaparackaite
Clinic of Paediatric Surgery, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania
Medicina (Kaunas) 39:105-13. 2003....
- Reproductive medicine in koi (Cyprinus carpio)Gregory A Lewbart
Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
Vet Clin North Am Exot Anim Pract 5:637-48, vii. 2002..In this country and in many parts of the world we refer to these fish as koi. Reproductive medicine problems are well documented in koi and a thorough knowledge of this subject will aid the fish practitioner in diagnosis and treatment...
- In vitro and in vivo effects of 17beta-trenbolone: a feedlot effluent contaminantVickie S Wilson
US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 70:202-11. 2002..In summary, TB is a potent environmental androgen both in vitro and in vivo and, in contrast to other reports, can induce developmental abnormalities in the fetus...
- Toxicological evaluations of long-term consumption of Solanum lycocarpum St. Hill fruits in male and female adult ratsV M Maruo
Department of Pathology, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Brazil
Phytomedicine 10:48-52. 2003..The present data, however, show sex-related differences in S. lycocarpum toxicity. Thus, other studies have to be conducted to better investigate female toxicity and other toxic effects of higher levels of exposure to this plant...
- [Cytotoxic effects of lead on the endocrine and exocrine sexual function of pubescent male and female rats. Demonstration of apoptotic activity]Fatma Gorbel
Laboratoire d éco physiologie animale, Faculte des Sciences de Sfax, 3018 Sfax, Tunisie
C R Biol 325:927-40. 2002..The cytotoxic effect of lead in males seems to be related to an apoptotic process...
- Avian reproductive anatomy, physiology and endocrinologyChristal G Pollock
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506 5606, USA
Vet Clin North Am Exot Anim Pract 5:441-74. 2002..Incubation is associated with falling LH levels and rising prolactin levels. If the hen actually enters reproductive quiescence at this time, then molt will follow. Molt is associated with the total regression of the reproductive tract...
- Novel therapy for female sexual dysfunctionGarry Southan; Fiscal Year: 2001..Topical application of traditional nitric oxide donors to the female genitalia, however, produces profound systemic side effects, including headache and hypotension...
- GENE REGULATION IN MAMMALIAN SEX DETERMINATIONHolly Ingraham; Fiscal Year: 2000..the secretion of MIS results in the regression or "cell death" of the Mullerian duct, the anlagen of internal female genitalia. Thus, regulation of MIS gene expression is directly coupled to the differentiation of the Sertoli cell and ..
- Blocking immune evasion as a novel HSV vaccine approachHARVEY MICHAEL FRIEDMAN; Fiscal Year: 2010..vaginal and flank models to address whether gD subunit vaccines are more effective at protecting mucosal (female genitalia) than epidermal (male genitalia) sites...
- Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsCharles Wira; Fiscal Year: 2007..These studies should provide the basis of knowledge essential for the development of more effective microbicides, therapeutic interventions, ..
- HOX GENE EXPRESSION IN HUMAN ENDOMETRIUMHugh Taylor; Fiscal Year: 2007..These studies will further characterize the molecular mechanisms by which HOX expression is related to normal and pathologic endometrial development. ..
- FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGYAbdulmaged Traish; Fiscal Year: 2003....
- DEVELOPMENT OF THE PRIMATE IMMUNOLOGY RESOURCEChristopher Miller; Fiscal Year: 2003..This type of sustained support for assay development is required if immune studies in non-human primates are going to significantly advance in the near future. ..
- CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSAKathleen Kelly; Fiscal Year: 2007..Insight into CXCL13 secretion will impact public health and the welfare of women in the US by aiding the development of therapeutics to prevent tubal infertility. ..
- METVAN: A Novel Anticancer AgentOSMOND D CRUZ; Fiscal Year: 2003..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
- PHI-443: Novel Non-Spermicidal Anti-HIV MicrobicideOSMOND D CRUZ; Fiscal Year: 2003..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
- Familial IgA Nephropathy: Genetic and Metabolic StudiesJiri Mestecky; Fiscal Year: 2006..abstract_text> ..
- 25th Annual Symposium on Nonhuman Primate Models for AIDSChristopher Miller; Fiscal Year: 2007..This format has been successfully followed using NCRR support for the previous Annual symposium. [unreadable] [unreadable] [unreadable]..
- Pelvic Floor Changes Before and After BirthREBECCA GLENN ROGERS; Fiscal Year: 2010..This project will provide fundamental data to guide future decisions about labor interventions to prevent PF changes as well as data-based decisions regarding maternal request cesarean. ..
- Stampidine: A Novel Broad-Spectrum Anti-HIV MicrobicideOSMOND D CRUZ; Fiscal Year: 2005..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
- Phase II SBIR: WHI-07: A Novel Dual-Function MicrobicideOSMOND D CRUZ; Fiscal Year: 2005....
- Vanadocenes as a New Class of Spermicidal DrugsOSMOND D CRUZ; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATIONJiri Mestecky; Fiscal Year: 2006..Results of these studies will generate information concerning previously unexplored inflammatory pathways that participate in the development of PD. ..
- MUCOSAL VACCINES AGAINST GONORRHEAMichael Russell; Fiscal Year: 2003..The information gained about genital tract immunity and the techniques used may also be applicable to other sexually transmitted diseases. ..
- NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITYOSMOND D CRUZ; Fiscal Year: 2001..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
- PROTECTIVE MECHANISMS WITH ATTENUATED LENTIVIRAL VACCINEChristopher Miller; Fiscal Year: 2002....
- FLP-102: Rationally Engineered Antiviral ProteinOSMOND D CRUZ; Fiscal Year: 2003..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
- ANNUAL SYMPOSIUM ON NONHUMAN PRIMATE MODELS FOR AIDSChristopher Miller; Fiscal Year: 2002..There will also be an evening banquet at the Monterey Bay Aquarium. ..
- ANTIGENS OF STREPTOCOCCUS MUTANS IN CARIES IMMUNITYMichael Russell; Fiscal Year: 2008..p RESEARCHGRANT TABLE OF CONTENTS Page Numbers Face Page ................................................................................................................................................ 1 Description, ..
- Effect of Microbicides on Mucosal HIV TransmissionChristopher Miller; Fiscal Year: 2004..Further, these studies will determine if individuals that consistently and correctly use of microbicides in the face of repeated viral exposure develop anti-viral immune responses or local infection. ..
- PHI 346: A Novel Dual-Function MicrobicideOSMOND D CRUZ; Fiscal Year: 2003..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
- Frequency and Function of HIV-specific T-cells in GALTBarbara Shacklett; Fiscal Year: 2003..We will also test alternate hypotheses to explain the apparent low levels of perforin expression in GALT. ..
- Injury from Sexual Assault: Addressing Health DisparityMarilyn S Sommers; Fiscal Year: 2010..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
- Suppression of Breakthrough Bleeding in LNG-IUS UsersOv Slayden; Fiscal Year: 2006..The proposal brings basic scientists and clinicians together for a "bench to bedside" approach that will advance women's health and improve contraceptive technology. ..
- Posttranslational Regulation of eNOS by Estrogen in the Vagina and ClitorisBiljana Musicki; Fiscal Year: 2007..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..
- PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2Gregg N Milligan; Fiscal Year: 2010..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
- Etiology of mastitis in HIV-1 infected womenLisa Frenkel; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- ANTIVIRAL THERAPY AND HIV IN THE GENITAL TRACT OF WOMENSusan Cu Uvin; Fiscal Year: 2007..We also propose to enroll women who have undergone total hysterectomy to assess HIV dynamics in the vagina. ..
- Vaccine-elicited genital and neuronal T cell responsesGregg Milligan; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Routine HIV Testing Among Adolescents and the Shifting Culture of AIDSLori Leonard; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- HERPES SIMPLEX VIRUS FC RECEPTORHarvey Friedman; Fiscal Year: 2009..This proposal addresses fundamental properties of HSV-1 gE, gl and Us9 related to infection of neurons and immune evasion. Understanding these activites may lead to novel therapies and better vaccines. ..
- Effects of Early Abuse on Adult Intimate RelationshipsCindy M Meston; Fiscal Year: 2010..The findings from this investigation will have implications for understanding both the psychological and physiological mechanisms that link CA with detrimental intimacy/relational factors in adulthood. ..
- In Utero Mammary Cancer Risk with Resveratrol and TCDDCORAL LAMARTINIERE; Fiscal Year: 2008..Programming breast cancer chemoprevention from in utero exposure to a nutritional agent would be a novel breakthrough for women's health. [unreadable] [unreadable] [unreadable]..
- Mechanisms of Sexual HIV-1 TransmissionFlorian Hladik; Fiscal Year: 2006..These studies will improve our knowledge of the human genital immune system and shed light on the mechanisms of HIV-l targeting and strain selection in the female genital tract. ..
- CELL CELL INTERACTIONS IN PROSTATE CANCERGerald Cunha; Fiscal Year: 2001..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
- GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTIONHunter Wessells; Fiscal Year: 2004..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
- Stromal Epithelial Interactions in Breast CancerGerald Cunha; Fiscal Year: 2004..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
- Genistein Impriting Against Prostate CancerCORAL LAMARTINIERE; Fiscal Year: 2003..We propose this in a dietary model at "physiological concentrations." ..
- NITRIC OXIDE REGULATORY SYSTEM IN THE PENISArthur Burnett; Fiscal Year: 2002....
- Immunization by HIV exposure during chemoprophylaxisLisa Frenkel; Fiscal Year: 2006..In the absence of an effective vaccine, the use of antiretrovirals should be optimized to prevent the spread of HIV-1 infection. This proposal works toward this goal. ..
- HSV PLANTIBODIES: A MICROBICIDAL LUBRICANTKevin Whaley; Fiscal Year: 2002..Vaginal rnicrobicides is one important application for mucosal antibodies but the technology is so flexible that it is readily extended to the prevention of diseases by pathogens at other mucosal sites. ..
- MUCOSAL PLANTIBODIES: ANTI-HIVKevin Whaley; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATION: Plantibodies offer a unique opportunity to provide large quantities of protective antibodies at a cost that enables technology that prevents mucosal transmission of a wide range of infectious diseases. ..
- HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTHGerald Cunha; Fiscal Year: 2001..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
- BAYLOR BIRCWH PROGRAMJoe Simpson; Fiscal Year: 2004..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
- Prenatal development, spatial ability, and hippocampusRebecca Herman; Fiscal Year: 2004..abstract_text> ..
- Oral HIV Pathogenesis and SheddingRobert Coombs; Fiscal Year: 2005..abstract_text> ..
- Neural Melanocortin Signaling and Erectile FunctionHunter Wessells; Fiscal Year: 2005..The findings may allow us to develop receptor-specific therapeutic strategies, which may ultimately be beneficial to men and women with sexual dysfunction. ..
- Synthetic smooth muscle cell-selective promotersBRIAN HERRING; Fiscal Year: 2006..Together these studies will provide a comprehensive analysis of the mechanisms regulating smooth muscle cell-selective gene expression in the genitourinary tract. [unreadable] [unreadable] [unreadable]..
- Plantibodies and Plantibody Hybrids as HIV MicrobicidesKevin Whaley; Fiscal Year: 2003..abstract_text> ..
- Immortalized Human Cavernosal Endothelial CellsHunter Wessells; Fiscal Year: 2005..abstract_text> ..
- Female sexuality: modulation by estrogen and androgenKim Wallen; Fiscal Year: 2005..These therapies will also be compared on their effects on neuroendocrine function. These studies will markedly increase our understanding of the role that ovarian steroids play in modulating women's sexuality. ..
- PHYSIOLOGY OF PUBERTY AND ANTISOCIAL BEHAVIORElizabeth Susman; Fiscal Year: 2003..The study will fill a major void in the literature as it aims to assess both the effect of hormones on behavior and the neurobiological effect of antisocial behavior on hormone concentrations. ..
- A Case Control Study of Interstitial CystitisJohn Warren; Fiscal Year: 2006..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
- Assessment of Penile Autonomic InnervationClaire Yang; Fiscal Year: 2007..The ability to detect cavernous neuropathy is relevant to the evaluation of erectile dysfunction, as well as the development of disease-specific treatments for neurogenic erectile dysfunction. [unreadable] [unreadable]..
- Mechanisms of HIV-1 Transmission in the Genital Mucosa of WomenFlorian Hladik; Fiscal Year: 2008..In this proposal, we will use a novel organ culture model of human vaginal tissue obtained from surgeries to characterize the entry pathways of HIV during the earliest stages of sexual transmission. [unreadable] [unreadable] [unreadable]..
- RCT OF STEPPING STONES BEHAVIOURAL INTERVENTION FOR HIVRachel Jewkes; Fiscal Year: 2005..It will also seek to understand what are the barriers to behavior change and what strategies are used by which people to circumnavigate these. ..
- BIOMARKERS FOR ANAL CANCERStephen Hawes; Fiscal Year: 2006..unreadable] [unreadable]..
- Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*Steven Witkin; Fiscal Year: 2005..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...
- MARYLAND INTERSTITIAL CYSTITIS CLINICAL TRIALS GROUPJohn Warren; Fiscal Year: 2003..This group will bring to the IC CTG experienced, motivated, and dedicated investigators; a new cadre of IC patients; and a network of referring urologists/gynecologists to study management strategies for this distressing disease. ..
- Genetics of Interstitial CystitisJohn Warren; Fiscal Year: 2007..The identification of alleles of susceptibility to IC may reveal clues to pathogenesis, clinical therapy, preventive strategy, and possibly gene therapies. ..
- NK effector mechanisms during NK-lymphoma interactionsCHARLES SENTMAN; Fiscal Year: 2007..These data will have implications for immunotherapy and tumor vaccines and suggest ways to develop more potent tumor immunity. [unreadable] [unreadable]..
- EPIDEMIOLOGY OF ORAL HIV 1 & 2 INFECTION IN HIGH RISK WOStephen Hawes; Fiscal Year: 2003....
- eNOS-Protein Interaction in the PenisBiljana Musicki; Fiscal Year: 2007..At the same time, it may suggest a specific eNOS regulatory pathway as a possible new molecular target for treating ED. [unreadable] [unreadable] [unreadable]..