mucous membrane

Summary

Summary: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of smooth muscle cells that separates the mucosa from submucosa.

Top Publications

  1. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
  2. ncbi Mucins in the mucosal barrier to infection
    S K Linden
    Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, Level 3 Aubigny Place, Mater Hospitals, South Brisbane, Queensland, Australia
    Mucosal Immunol 1:183-97. 2008
  3. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
  4. ncbi ATP drives lamina propria T(H)17 cell differentiation
    Koji Atarashi
    Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 455:808-12. 2008
  5. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
  6. ncbi Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    Satoshi Uematsu
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 9:769-76. 2008
  7. pmc Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 296:202-11. 2006
  8. ncbi Barrier properties of mucus
    Richard A Cone
    Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
    Adv Drug Deliv Rev 61:75-85. 2009
  9. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
  10. ncbi HIV infection of the genital mucosa in women
    Florian Hladik
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3 100, Seattle, WA 98109 1024, USA
    Curr HIV/AIDS Rep 6:20-8. 2009

Detail Information

Publications342 found, 100 shown here

  1. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion...
  2. ncbi Mucins in the mucosal barrier to infection
    S K Linden
    Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, Level 3 Aubigny Place, Mater Hospitals, South Brisbane, Queensland, Australia
    Mucosal Immunol 1:183-97. 2008
    ....
  3. pmc Glycerol monolaurate prevents mucosal SIV transmission
    Qingsheng Li
    Department of Microbiology, Medical School, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, Minnesota 55455, USA
    Nature 458:1034-8. 2009
    ....
  4. ncbi ATP drives lamina propria T(H)17 cell differentiation
    Koji Atarashi
    Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 455:808-12. 2008
    ..These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria...
  5. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  6. ncbi Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    Satoshi Uematsu
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 9:769-76. 2008
    ..Our findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine...
  7. pmc Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 296:202-11. 2006
    ....
  8. ncbi Barrier properties of mucus
    Richard A Cone
    Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
    Adv Drug Deliv Rev 61:75-85. 2009
    ..These viruses are smaller than the mucus mesh spacing, and have surfaces that do not stick to mucus. They form a useful model for developing NP for mucosal drug delivery...
  9. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
    ..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
  10. ncbi HIV infection of the genital mucosa in women
    Florian Hladik
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3 100, Seattle, WA 98109 1024, USA
    Curr HIV/AIDS Rep 6:20-8. 2009
    ..Studies using human explant tissues and in vivo animal studies have improved our understanding of the cellular and molecular pathways of infection; this information could be harnessed to design effective HIV vaccines and microbicides...
  11. ncbi Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    Timothy L Denning
    Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Nat Immunol 8:1086-94. 2007
    ..This IL-17 production was suppressed by lamina propria macrophages, indicating that a dynamic interaction between these subsets may influence the balance between immune activation and tolerance...
  12. pmc Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus
    Norifumi Iijima
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 205:3041-52. 2008
    ..Thus, these results revealed a distinct mechanism by which memory Th1 cells mediate noncytolytic IFN-gamma-dependent antiviral protection after recognition of processed viral antigens by local DCs and B cells...
  13. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
    ..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
  14. ncbi Synthesis and characterisation of mucoadhesive thiolated polymers
    A Bernkop-Schnürch
    Institute of Pharmaceutical Technology, Center of Pharmacy, University of Vienna, Althanstrasse 14, A 1090, Vienna, Austria
    Int J Pharm 194:239-47. 2000
    ..The results represent helpful basic information in order to improve the mucoadhesive properties of thiolated polymers...
  15. ncbi Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Pharm 389:24-31. 2010
    ....
  16. ncbi Optimization of methods to assess human mucosal T-cell responses to HIV infection
    Barbara L Shacklett
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA
    J Immunol Methods 279:17-31. 2003
    ..Taken together, these methods will be useful for studies of mucosal immunity to HIV-1 and other pathogens during natural infection and following vaccination...
  17. pmc Management of esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    BMC Gastroenterol 11:46. 2011
    ..We examined the effectiveness of systemic steroid administration for control of postprocedural esophageal stricture after complete circular ESD...
  18. ncbi Female genital tract immunity: distinct immunological challenges for vaccine development
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, WV 26506 9186, USA
    J Reprod Immunol 93:1-8. 2012
    ..Thus, as well as active immunization using selected routes, the passive immunization approach may provide a viable alternative to vaccinology for future development...
  19. ncbi The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages
    Y Ganor
    Department of Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology, and Host Pathogen Interactions, Cochin Institute, INSERM, U1016, Paris, France
    Mucosal Immunol 6:776-86. 2013
    ..Our results identify the male urethra as a novel entry site for HIV-1 that targets resident urethral macrophages. These results might explain the incomplete prophylactic efficacy of male circumcision in reducing HIV-1 transmission...
  20. ncbi Herpes simplex virus-2 in the genital mucosa: insights into the mucosal host response and vaccine development
    Amanda J Lee
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics and Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Infect Dis 25:92-9. 2012
    ..This review aims to summarize the innate and adaptive immune responses against HSV-2 and examines the current status of vaccine development...
  21. ncbi Targeting early infection to prevent HIV-1 mucosal transmission
    Ashley T Haase
    Department of Microbiology, University of Minnesota, Minnesota 55455, USA
    Nature 464:217-23. 2010
    ....
  22. ncbi Infection of macaques after vaginal exposure to cell-associated simian immunodeficiency virus
    Bettina Salle
    Commissariat a l Energie Atomique CEA, Division of Immuno Virology, Institute of Emerging Diseases and Innovative Therapies IMETI, Fontenay aux Roses, France
    J Infect Dis 202:337-44. 2010
    ..The contribution of infected semen cells to sexual transmission of human immunodeficiency virus (HIV) is still debated. We addressed this issue in the model of experimental infection of macaques with simian immunodeficiency virus (SIV)...
  23. pmc Pathogenic consequences of vaginal infection with CCR5-tropic simian-human immunodeficiency virus SHIVSF162P3N
    Madina Shakirzyanova
    Aaron Diamond AIDS Research Center, New York, New York, USA
    J Virol 86:9432-42. 2012
    ..However, the administered dose appears to impact SHIV(SF162P3N) vaginal infection outcome in an unexpected manner...
  24. pmc Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells
    Wei Jen Chua
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 186:4744-50. 2011
    ..Based on this pattern of MR1 expression, it is intriguing to speculate that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut and/or detection of pathogenic bacteria in mucosal tissues...
  25. ncbi Sublingual mucosa: A new vaccination route for systemic and mucosal immunity
    Mi Na Kweon
    Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Republic of Korea
    Cytokine 54:1-5. 2011
    ..l. administration. This review highlights current knowledge about the safety and effectiveness of s.l. vaccination and describes how s.l. vaccination can induce both systemic and mucosal immunity...
  26. ncbi Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract
    Catherine Hervouet
    INSERM, U634, Faculté de Médecine Pasteur, 06107 Nice Cedex 2, France
    Vaccine 28:5582-90. 2010
    ..Sublingual vaccination could represent a promising vaccine strategy against heterosexual transmission of HIV-1...
  27. pmc Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier
    PABLO ARGUESO
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 284:23037-45. 2009
    ..Taken together, these results suggest that galectin-3 plays a key role in maintaining mucosal barrier function through carbohydrate-dependent interactions with cell surface mucins...
  28. ncbi Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa
    Christopher A Squier
    Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 54222, USA
    J Pharm Sci 97:9-21. 2008
    ....
  29. pmc Spatiotemporal and functional behavior of airway dendritic cells visualized by two-photon microscopy
    Tibor Z Veres
    Department of Airway Immunology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Am J Pathol 179:603-9. 2011
    ..Our results provide a first description of the dynamic behavior of airway mucosal DCs, with their exact role in antigen sampling remaining unclear...
  30. ncbi Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus infection
    Nicolas Cuburu
    Laboratory Sciences Division, International Vaccine Institute, Seoul, Korea
    J Immunol 183:7851-9. 2009
    ..l. immunization as an efficient vaccination strategy for inducing genital immune responses and should impact on the development of vaccines against sexually transmitted diseases...
  31. pmc Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice
    Bradford K Berges
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virology 373:342-51. 2008
    ....
  32. pmc Host responses to Candida albicans: Th17 cells and mucosal candidiasis
    Heather R Conti
    University at Buffalo, SUNY, Department of Oral Biology, Buffalo, NY, USA
    Microbes Infect 12:518-27. 2010
    ..However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis...
  33. pmc Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts?
    P Sadananda
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Br J Pharmacol 153:1465-73. 2008
    ..The bladder urothelium is now known to have active properties. Our aim was to investigate the contractile properties of the urinary mucosa in response to the tachykinin neurokinin A (NKA) and carbachol...
  34. pmc Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:359-70. 2009
    ..Thus, both migrant and resident DCs play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo...
  35. ncbi Long-term outcome after endoscopic mucosal resection in patients with esophageal squamous cell carcinoma invading the muscularis mucosae or deeper
    Yuichi Shimizu
    Division of Endoscopy, Third Department of Internal Medicine, Hokkaido University Medical Hospital, Sapporo, Japan
    Gastrointest Endosc 56:387-90. 2002
    ..This study prospectively evaluated long-term outcome in such patients...
  36. ncbi HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis
    D Tudor
    Entrée Muqueuse du VIH et Immunité Muqueuse, Mucosal Entry of HIV 1 and Mucosal Immunity, Departement de Biologie Cellulaire, Cell Biology Department, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 2:412-26. 2009
    ..This analysis of HEPS monoclonal IgA gives a unique opportunity to correlate an antibody function (resistance to a pathogen in vivo) with an antibody gene. Such neutralizing monoclonal IgAs could be used in microbicide formulation...
  37. ncbi Endoscopic submucosal dissection of esophageal squamous cell neoplasms
    Mitsuhiro Fujishiro
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 4:688-94. 2006
    ..Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus...
  38. pmc Claudin 4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery
    Thejani E Rajapaksa
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    J Control Release 142:196-205. 2010
    ..Our results suggest that a reasonably simple nanoparticle manufacture method can provide insight into developing an effective needle-free delivery system...
  39. ncbi Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 287:1710-5. 2002
    ....
  40. ncbi Chitosan and its derivatives in mucosal drug and vaccine delivery
    I M van der Lubben
    Leiden/Amsterdam Center for Drug Research, Division of Pharmaceutical Technology, P.O. Box 9502, 2300 RA, Leiden, The Netherlands
    Eur J Pharm Sci 14:201-7. 2001
    ..From the studies reviewed it is concluded that chitosan and chitosan derivatives are promising polymeric excipients for mucosal drug and vaccine delivery...
  41. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    ..tularensis, a category A biothreat agent. In summary, these studies show for the first time the use of FcRs as a highly effective vaccination strategy against a highly virulent mucosal intracellular pathogen...
  42. pmc Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
    ..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
  43. pmc Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1
    Florian Hladik
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Immunity 26:257-70. 2007
    ..Our findings shed light on the very earliest steps of mucosal HIV infection in vivo and may guide the design of effective strategies to block local transmission and prevent HIV-1 spread...
  44. pmc Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
    Nobuhiko Kamada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Clin Invest 118:2269-80. 2008
    ..Collectively, these data suggest that this IL-23/IFN-gamma-positive feedback loop induced by abnormal intestinal macrophages contributes to the pathogenesis of chronic intestinal inflammation in patients with CD...
  45. pmc Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes
    Agnes L Chenine
    Dana Farber Cancer Institute, Massachusetts General Hospital, Boston, Massachusetts 02115 6084, USA
    J Infect Dis 201:1155-63. 2010
    ..Worldwide, approximately 90% of all human immunodeficiency virus (HIV) transmissions occur mucosally; almost all involve R5 strains. Risks of sexual HIV acquisition are highest for rectal, then vaginal, and finally oral exposures...
  46. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Our data indicate that IL-10 released from myeloid cells acts in a paracrine manner on T(reg) cells to maintain Foxp3 expression...
  47. ncbi Mucoadhesive polymeric platforms for controlled drug delivery
    Gavin P Andrews
    School of Pharmacy, The Queen s University of Belfast, Belfast, Ireland
    Eur J Pharm Biopharm 71:505-18. 2009
    ..Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer networks to more specific second-generation systems based on lectin, thiol and various other adhesive functional groups...
  48. ncbi Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan
    Jeffrey N Roberts
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4263, USA
    Nat Med 13:857-61. 2007
    ..In contrast, carrageenan, a polysaccharide present in some vaginal lubricants, prevented infection even in the presence of N-9, suggesting that carrageenan might serve as an effective topical HPV microbicide...
  49. ncbi HIV disease: fallout from a mucosal catastrophe?
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 7:235-9. 2006
    ....
  50. ncbi Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 188:1345-51. 2003
    ..In home-collected specimens, the ratio of PCR positivity to viral-culture positivity rose from 3.8:1 in the winter to 8.8:1 in the summer months, reflecting the lability of viral-culture specimens transported during warm weather...
  51. ncbi Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers
    Shehzad M Iqbal
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Infect Dis 192:728-38. 2005
    ..This is the first study to show elevated levels of beta chemokines and CD4+ T cells in the genital tracts of women who are exposed to HIV-1 and yet are uninfected...
  52. ncbi A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge
    X Zhang
    Laboratory of Cellular and Molecular Immunology, The Gavin S Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, USA
    Mucosal Immunol 2:129-43. 2009
    ..IVAG immunization with self-adjuvanting lipid-tailed peptides appears to be a novel mucosal vaccine approach, which has attractive practical and immunological features...
  53. ncbi Transepithelial pathogen uptake into the small intestinal lamina propria
    Alexandra Vallon-Eberhard
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 176:2465-9. 2006
    ....
  54. ncbi Collaboration of epithelial cells with organized mucosal lymphoid tissues
    M R Neutra
    Children s Hospital and Harvard Medical School, Enders 1220, 300 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 2:1004-9. 2001
    ..Determination of the earliest cellular interactions that occur in and under the follicle-associated epithelium could greatly facilitate the design of effective mucosal vaccines in the future...
  55. ncbi Polysaccharide colloidal particles as delivery systems for macromolecules
    K A Janes
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
    Adv Drug Deliv Rev 47:83-97. 2001
    ..The potential applications and future prospects of these new systems for mucosal delivery of macromolecules are highlighted at the end of the chapter...
  56. ncbi Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Drug Dev Ind Pharm 35:986-96. 2009
    ..CMC films prepared at 45 degrees C and 6% RH produced suitable films at the fastest rate while films containing equal quantities of glycerol and CMC possessed an ideal balance between flexibility and rigidity...
  57. pmc Characterization of mucosal Candida albicans biofilms
    Anna Dongari-Bagtzoglou
    Division of Periodontology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut, United States of America
    PLoS ONE 4:e7967. 2009
    ....
  58. ncbi Early mucosal responses in blue catfish (Ictalurus furcatus) skin to Aeromonas hydrophila infection
    Chao Li
    Department of Fisheries and Allied Aquacultures, Auburn University, Auburn, AL 36849, USA
    Fish Shellfish Immunol 34:920-8. 2013
    ..Taken together, A. hydrophila coordinately modulates mucosal factors across numerous cellular pathways in a manner predicted to enhance its ability to adhere to and infect the blue catfish host...
  59. pmc Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder
    Thomas J Heppner
    Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Regul Integr Comp Physiol 301:R351-62. 2011
    ....
  60. ncbi Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction
    Seema S Aceves
    Division of Allergy and Immunology, University of California and Rady Children s Hospital, San Diego, USA
    J Allergy Clin Immunol 126:1198-204.e4. 2010
    ..However, mast cell infiltration into the esophageal lamina propria (LP) and smooth muscle (SM) and the effects of their products on SM function has not been determined...
  61. ncbi Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients
    Danny Yakoub
    Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, United Kingdom
    Cancer Res 70:9129-36. 2010
    ..This indicates that metabolic profiling of tissue can potentially play a role in the surveillance of cancer by reporting on the phenotypic consequences of field cancerization...
  62. pmc A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel
    Marla J Keller
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 6:e16475. 2011
    ....
  63. pmc IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells
    J Laoukili
    Laboratoire de Cytophysiologie et Toxicologie Cellulaire, , Paris, France
    J Clin Invest 108:1817-24. 2001
    ..These results suggest that, in human allergic asthmatic responses, IL-13 affects both ciliated and secretory cell differentiation, leading to airway damage and obstruction...
  64. ncbi Characterization of seven novel human papillomavirus types isolated from cutaneous tissue, but also present in mucosal lesions
    Ethel Michele de Villiers
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Gen Virol 90:1999-2004. 2009
    ..The general prevalence of these HPV types in lesions is infrequent...
  65. pmc Starch source influences dietary glucose generation at the mucosal α-glucosidase level
    Amy Hui Mei Lin
    Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, West Lafayette, Indiana 47907 2009, USA
    J Biol Chem 287:36917-21. 2012
    ..Strategies to control the rate of glucogenesis at the mucosal level could lead to regulation of the glycemic response and improved glucose management in the human body...
  66. pmc Cytolysins augment superantigen penetration of stratified mucosa
    Amanda J Brosnahan
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 182:2364-73. 2009
    ....
  67. ncbi Evasion of mucosal defenses during Aeromonas hydrophila infection of channel catfish (Ictalurus punctatus) skin
    Chao Li
    Department of Fisheries and Allied Aquacultures, Auburn University, Auburn, AL 36849, USA
    Dev Comp Immunol 39:447-55. 2013
    ..In particular, A. hydrophila infection rapidly altered a number of potentially critical lectins, chemokines, interleukins, and other mucosal factors in a manner predicted to enhance its ability to adhere to and invade the catfish host...
  68. pmc Protection against high-dose highly pathogenic mucosal SIV challenge at very low serum neutralizing titers of the antibody-like molecule CD4-IgG2
    Pascal Poignard
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e42209. 2012
    ....
  69. pmc Innate and acquired immunity in the human penile urethra
    Jeffrey Pudney
    Department of Obstetrics and Gynecology, Boston University, School of Medicine, Boston, MA 02118, USA
    J Reprod Immunol 88:219-27. 2011
    ..Further research is needed to define approaches to stimulate immunity at this mucosal site to prevent the transmission of HIV-1 and other sexually transmitted pathogens...
  70. pmc Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies
    Rajeev Gautam
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:8516-26. 2012
    ....
  71. ncbi Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide
    Yuan Yuan
    Department of Pharmacy, Logistic University of Chinese People s Armed Police Forces, China
    Int J Pharm 430:114-9. 2012
    ..In addition, it resulted in significantly higher initial serum concentrations, C(max) and AUC of NM compared to the solid suppository...
  72. ncbi Large cell neuroendocrine carcinoma of the head and neck
    Kimihide Kusafuka
    Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan
    Oral Oncol 48:211-5. 2012
    ..This article describes their characteristic light microscopic and immunohistochemical features and highlights the importance of accurate diagnosis, management and prognostic implications...
  73. ncbi Fasting and refeeding cause rapid changes in intestinal tissue mass and digestive enzyme capacities of Atlantic salmon (Salmo salar L.)
    Ashild Krogdahl
    Aquaculture Protein Centre, Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
    Comp Biochem Physiol A Mol Integr Physiol 141:450-60. 2005
    ..Investigations of digestive processes of fed fish should only be performed when intestines are feed-filled to avoid bias due to effects of fasting...
  74. pmc HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV
    Claudia Cicala
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:S2. 2011
    ....
  75. pmc Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients
    K Elgbratt
    Department of Clinical Medicine, Orebro University, Sweden
    Clin Exp Immunol 162:325-36. 2010
    ....
  76. ncbi Mucosal Leishmania infantum leishmaniasis: specific pattern in a multicentre survey and historical cases
    Benoit Faucher
    Laboratoire de Parasitologie et Mycologie, Centre Hospitalo Universitaire de la Timone, Assistance publique Hôpitaux de Marseille AP HM, 13385 Marseille, France
    J Infect 63:76-82. 2011
    ..Leishmania infantum mucosally restricted leishmaniasis was rarely reported, so that diagnostic and treatment strategies remain debated. A long-term multicentric survey appeared thereby necessary...
  77. ncbi Efficacy of concurrent application of chlorhexidine gluconate and povidone iodine against six nosocomial pathogens
    Michele J Anderson
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Infect Control 38:826-31. 2010
    ..Chlorhexidine gluconate (CHG) and povidone iodine (PI) are rarely used concurrently despite a lack of evidence regarding functional incompatibility of these agents...
  78. ncbi Predictive factors for esophageal stenosis after endoscopic submucosal dissection for superficial esophageal cancer
    H Mizuta
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Dis Esophagus 22:626-31. 2009
    ..Although ESD enables large en bloc resection of esophageal cancer, practically, in cases with a lesion more than half of the circumference, great care must be taken because of the high risk of post-ESD stenosis...
  79. ncbi Direct evidence of bacterial biofilms in otitis media
    J C Post
    Department of Pediatric Otolaryngology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4722, USA
    Laryngoscope 111:2083-94. 2001
    ..The objective of this study was to collect visual evidence of the formation of bacterial biofilms in these situations...
  80. pmc The role of DNA sensing and innate immune receptor TLR9 in otitis media
    Anke Leichtle
    Department of Surgery Otolaryngology, University of Lubeck, Lubeck, Germany
    Innate Immun 18:3-13. 2012
    ..The results suggest that DNA sensing via TLR9 plays a role in OM pathogenesis and recovery. Alternative forms of DNA sensing may also contribute to OM...
  81. ncbi Process of healing of mucosal defects in the esophagus after endoscopic mucosal resection: histological evaluation in a dog model
    M Honda
    Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, Kyoto, Japan
    Endoscopy 42:1092-5. 2010
    ..The aim of this study was to evaluate the process of healing of defects in the esophageal mucosa after endoscopic mucosal resection (EMR)...
  82. ncbi Autologous buccal keratinocyte implantation for the prevention of stenosis after EMR of the esophagus
    Tadashi Sakurai
    Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Gastrointest Endosc 66:167-73. 2007
    ..We, therefore, hypothesized that, by applying the technology of regenerative medicine, the stricture occurring in the esophagus after EMR on broad lesions could be prevented...
  83. ncbi Dendritic cells in the human decidua
    Lucy Gardner
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Biol Reprod 69:1438-46. 2003
    ..They were also visible in endothelial-lined spaces. This is the first study to identify and describe the phenotype and distribution of human decidual DCs...
  84. pmc Human mucosal associated invariant T cells detect bacterially infected cells
    Marielle C Gold
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Biol 8:e1000407. 2010
    ..Overall, these findings suggest a generalized role for MAIT cells in the detection of bacterially infected cells, and potentially in the control of bacterial infection...
  85. pmc Setting of methods for analysis of mucosal antibodies in seminal and vaginal fluids of HIV seropositive subjects from Cambodian and Italian cohorts
    Carla Donadoni
    Division of Immunology, Infectious Diseases and Trasplantation, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 5:e9920. 2010
    ..High variability of published observations concerning IgA isolation and quantification underlies the strong requirement of specific methods able to maximize investigation on HIV-specific IgA...
  86. ncbi Proteome reference map of the skin mucus of Atlantic cod (Gadus morhua) revealing immune competent molecules
    Binoy Rajan
    Aquatic Animal Health Research Group, Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodø, Norway
    Fish Shellfish Immunol 31:224-31. 2011
    ..Five of the aforementioned proteins were cloned and their tissue distribution was analysed by RT-PCR...
  87. ncbi Dietary heme injures surface epithelium resulting in hyperproliferation, inhibition of apoptosis and crypt hyperplasia in rat colon
    Johan de Vogel
    TI Food and Nutrition, PO Box 557, 6700 AN Wageningen, The Netherlands
    Carcinogenesis 29:398-403. 2008
    ..This disturbed epithelial cell homeostasis might explain why a high intake of dietary heme is associated with an increased risk of colon cancer...
  88. ncbi Enemy at the gates: dendritic cells and immunity to mucosal pathogens
    Adam C Soloff
    Center for Vaccine Research, University of Pittsburgh, Pennsylvania 15261, USA
    Cell Res 20:872-85. 2010
    ..Finally, DC interact with each other through crosstalk to promote antigen presentation and T-cell immunity. Together, these processes condition mucosal DC for the induction of a tailored immune response to pathogens...
  89. pmc Multi-species bacterial biofilm and intracellular infection in otitis media
    Ruth B Thornton
    School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia
    BMC Pediatr 11:94. 2011
    ..The aim of this project is to provide evidence for the presence of otopathogenic bacteria intracellularly or within biofilm in the middle ear mucosa of children with COME or rAOM...
  90. ncbi Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis
    Ping Zhang
    Microbiology Department, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Vaccine 21:4459-71. 2003
    ..These results demonstrate the effectiveness of GPI-0100 as both a systemic and mucosal adjuvant and support its potential use in the development of vaccines against periodontal, as well as other pathogens...
  91. pmc An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection
    Tao Peng
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Virol 86:10587-96. 2012
    ..Many of these transcripts are known to have half-lives of <48 h, suggesting that cognate antigen is released frequently into the mucosa and that resident CD8(+) T cells act as functional effectors in controlling viral spread...
  92. ncbi Relationship between the distribution of pseudoxanthoma elasticum skin and mucous membrane lesions and cardiovascular involvement
    Atsushi Utani
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Dermatol 37:130-6. 2010
    ..To determine the relationship between the distribution of skin and mucous membrane lesions and the prevalence of CVD in patients with PXE, we examined 14 PXE cases who presented between 2004 ..
  93. ncbi An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR
    Alejandro Nieponice
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Gastrointest Endosc 69:289-96. 2009
    ..One of the limitations of this technique is that extensive mucosal resection and endoscopic submucosal dissection may be required to obtain complete removal of the neoplasm, which may result in significant stricture formation...
  94. ncbi Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagus
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit and AIDS Reference Centre, National Cancer Institute Fond Pascale, Naples, Italy
    J Clin Virol 45:28-33. 2009
    ..Still controversial is the association of HPV infection with oesophageal neoplasia...
  95. pmc Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice
    Aoife M Roche
    Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104 6076, USA
    Infect Immun 75:2469-75. 2007
    ..Thus, colonization by live attenuated S. pneumoniae is a potentially safe and less complex vaccine strategy that may offer broad protection...
  96. ncbi The role of chronic infection in children with otitis media with effusion: evidence for intracellular persistence of bacteria
    Harvey Coates
    Department of ENT Surgery, Princess Margaret Hospital for Children, Perth, Western Australia
    Otolaryngol Head Neck Surg 138:778-81. 2008
    ..Demonstrate mucosal bacterial infection in children with otitis media with effusion (OME)...
  97. pmc Expression of mucins in mucoid otitis media
    Jizhen Lin
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Assoc Res Otolaryngol 4:384-93. 2003
    ..Further study indicated that the mucin hyperproduction was significantly linked to CD4+ and CD8+ T cells and/or CD68+ monocyte macrophages. It suggests that MUC5B and MUC4 expression may be regulated by the products of these cells...
  98. pmc Respiratory mucosal immunization with reovirus serotype 1/L stimulates virus-specific humoral and cellular immune responses, including double-positive (CD4(+)/CD8(+)) T cells
    S B Periwal
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    J Virol 73:7633-40. 1999
    ..These results establish reovirus 1/L as a viable model for future investigation of the mucosal immune response in the RALT and its relationship to the common mucosal immune system...
  99. pmc Differences in immunoregulatory cytokine expression patterns in the systemic and genital tract compartments of HIV-1-infected commercial sex workers in Benin
    J Lajoie
    Laboratoire d Immunogénétique, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Canada
    Mucosal Immunol 1:309-16. 2008
    ..The increased production of genital mucosal pro-inflammatory cytokines in HIV-1-infected CSWs possibly reflects susceptibility to HIV-1 infection and disease progression/perpetuation at the initial site of exposure...
  100. ncbi Biomarkers of leukocyte traffic and activation in the vaginal mucosa
    Radiana T Trifonova
    Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biomarkers 12:608-22. 2007
    ..These biomarkers, which were also detected in human vaginal secretions, may be used to enhance the characterization of mucosal safety of vaginally applied compounds, both in animal as well as clinical studies...
  101. ncbi Terminology: nomenclature of mucosa-associated lymphoid tissue
    P Brandtzaeg
    Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Mucosal Immunol 1:31-7. 2008
    ..In addition, we recommend and justify standard nomenclature and abbreviations for discrete mucosal immune-cell compartments, belonging to, and beyond, mucosa-associated lymphoid tissue...

Research Grants63

  1. ORAL MUCOSA MICROBIOTA IN HEALTH, CANCER & MUCOSITIS
    Donna Mager; Fiscal Year: 2004
    ..Specific Aims are 1. To compare the microbial composition of samples from 8 different oral mucous membrane sites with that found in saliva, supra and sub-gingival plaque in subjects stratified according to ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  4. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..abstract_text> ..
  5. MECHANISM OF PATHOGENIC ACTIVITY OF PEPTIDOGLYCAN
    Roman Dziarski; Fiscal Year: 2012
    ..abstract_text> ..
  6. Dysregulation of microRNAs in HPV-Positive Oropharyngeal Cancers
    Abigail Wald; Fiscal Year: 2012
    ..Exploring the differences in miRNA expression in HPV-positive and HPV-negative SCCHN could lead to better diagnostics, treatments, and cures for oropharyngeal cancers. ..
  7. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ....
  8. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..Leptospirosis is contracted through skin or mucous membrane contact with urine of infected animals...
  9. Mechanism of skin-specific targeting of adult stem cells
    Olga Igoucheva; Fiscal Year: 2013
    ..A successful outcome of these studies may form a platform for development of a novel therapeutic approach for curing connective tissue disorders as well as other human genetic disorders. ..
  10. Cell-Binding Adhesins of Leptospira interrogans
    Jenifer L Coburn; Fiscal Year: 2013
    ..As a step toward development of improved vaccines, we will identify and establish the significance of leptospiral molecules required for the bacteria to cause infection and disease manifestations. ..
  11. Oral prodrug of a novel antiviral that blocks neuronal reactivation of HSV
    George E Wright; Fiscal Year: 2012
    ..Sacrovir represents a first-in-class, novel oral treatment for latent herpes simplex infections of neurons and, importantly, will prevent transmission of infectious virus. ..
  12. Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa
    MATT PETER MARINKOVICH; Fiscal Year: 2013
    ..We plan to correct the affected person's own skin cells and transplant their own cells back onto their skin. Effective gene therapy in this skin disease will assist in development of gene therapy for other genetic diseases. ..
  13. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2012
    ..Our experimental approaches will include the generation and analysis of transgenic mice, microscopic imaging of neural function, electrophysiological techniques and genetic and biochemical approaches. ..
  14. Tissue Engineering of a Neotrachea
    James E Dennis; Fiscal Year: 2013
    ..Particular attention will be paid to the fibrosis, the formation of a mucous membrane, and also whether bone forms within the neotrachea...
  15. Mucosal Adjuvants Targeting Dendritic Cells
    John G Nedrud; Fiscal Year: 2010
    ..It will develop a new class of intranasal vaccines which combine antigens, a substance to enhance immune responses (an adjuvant) and a way to direct the vaccine to the tissues where an immune response to the vaccine is initiated. ..
  16. Novel molecular therapeutics for cystic fibrosis
    David E Sterner; Fiscal Year: 2012
    ..Progenra proposes to develop a small molecule inhibitor of the enzyme (gp78) that degrades this mutated protein to restore salt balance and achieve therapeutic benefit. ..
  17. Leishmaniasis Drug Development Using an Evolutionary Design Strategy
    Roger G Linington; Fiscal Year: 2010
    ..In the course of this study we aim to both develop new effective treatments for this disease and to determine the mechanism by which these drugs exert their effect against the target parasite. ..
  18. Staphylococcal Superantigen Interactions With Vaginal Epithelium
    Marnie L Peterson; Fiscal Year: 2012
    ..This application studies the mechanism by which superantigens penetrate mucosal surfaces, allowing S. aureus to cause life threatening toxic shock syndrome, and possibly suggesting novel strategies to prevent and manage such illnesses. ..
  19. High throughput screening to find inhibitors of pathogenic pemphigus antibodies
    John R Stanley; Fiscal Year: 2012
    ..Current therapy is to suppress the immune system, which results in many potential adverse effects. This proposal seeks therapy directly targeted only to the autoantibodies that actually cause the blisters in this disease. ..
  20. Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease Pemphigus
    Andrew P Kowalczyk; Fiscal Year: 2012
    ....
  21. Cloning and genetics of human pemphigus autoantibodies
    John R Stanley; Fiscal Year: 2013
    ..These studies will elucidate the pathophysiology of the autoimmune response in pemphigus with implications for therapy. ..
  22. Structural investigation of Helicobacter pylori transcription regulator NikR
    SARAH ELIZABETH JOHNSON BOWMAN; Fiscal Year: 2011
    ..near the gastric lumen and to thrive in the neutral pH environment near the epithelial layer of the gastric mucous membrane. The objective of this proposal is to use complementary experimental and computational techniques to ..
  23. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer Coburn; Fiscal Year: 2009
    ..interrogans. ..
  24. Antifungal drugs: Beta(1,6)-glucan synthesis inhibitors
    Claude Selitrennikoff; Fiscal Year: 2003
    ..We predict that, since humans do not have the pathway for beta (1,6) glucan synthesis, inhibitors will be safe and effective therapeutics. ..
  25. The glyoxylate cycle as a new target for antifungals
    Claude Selitrennikoff; Fiscal Year: 2003
    ..The applicant predicts that, since humans do not have the glyoxylate cycle, the inhibitors will be safe and effective therapeutics. ..
  26. Leptospira interrogans Len adhesins
    Brian Stevenson; Fiscal Year: 2009
    ..The aim of this project is to characterize a family of six leptospiral proteins we found to interact with human immune system regulators and extracellular matrix components, and may therefore play important roles in human leptospirosis. ..
  27. Cell-Based Therapy for Dystrophic Epidermolysis Bullosa
    Olga Igoucheva; Fiscal Year: 2009
    ..If successful, the suggested strategy may become powerful therapeutic approach for treatment of connective tissue disorders, in particular dystrophic epidermolysis bullosa, and benefit public health. ..
  28. DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELS
    Timothy Wiedmann; Fiscal Year: 2000
    ..Moreover, elucidation of the limiting physical chemistry of lipids and mucin will form the basis for the structure/function of mucous membranes throughout the body. ..
  29. Enhanced Disinfection of Medical Facilities
    DANIEL AVERY; Fiscal Year: 2003
    ..Phase I will also demonstrate the stability of medical device materials (eg. stainless steel, polytetrafluoroethylene (PTFE)) when exposed to Compact Membrane Systems, Inc. novel disinfection system. ..
  30. Molecular Basis of Francisella Virulence and Immunity
    THOMAS KAWULA; Fiscal Year: 2005
    ..of an animal host, and numerous transmission mechanisms including inhalation, ingestion, skin contact, mucous membrane contact, and insect vectors. Little is known about the mechanisms of F...
  31. Improving Clinical Outcomes for Early Chilhood Caries
    Robert Berkowitz; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  32. Novel Therapy for Pemphigus Vulgaris by Treatment with a Cholinergic Agonist
    Susan Wright; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The goal of this project is to develop a novel therapy for the life-threatening skin disease, pemphigus vulgarus. ..
  33. ALTERED GENE EXPRESSION IN OCULAR CICATRICIAL PEMPHIGOID
    MELVIN ROAT; Fiscal Year: 1990
    ..By understanding the cellular and molecular basis of the pathologic scarring responsible for the blinding and painful symptoms of cicatricial pemphigoid, we may be able to develop safe and effective new therapies...
  34. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  35. Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease Pemphigus
    Andrew Kowalczyk; Fiscal Year: 2007
    ..abstract_text> ..
  36. PATHOGENESIS OF PEMPHIGUS
    John Stanley; Fiscal Year: 2001
    ..in PF, anti-desmoglein 1 (Dsg1) antibodies cause loss of cell adhesion in superficial epidermis but not in mucous membrane. It has been speculated that pemphigus antibodies cause loss of cell adhesion directly by their effect on ..
  37. Antiviral Drugs for Treatment of Herpes B Infections
    George Wright; Fiscal Year: 2003
    ....
  38. SECRETORY IMMUNOGLOBULIN
    MICHAEL LAMM; Fiscal Year: 2002
    ....
  39. INITIAL EVENTS IN TRANSMUCOSAL LENTIVIRUS INFECTION
    AMY RULLKOETTER; Fiscal Year: 2000
    ..three specific aims addressed are: (1) to determine whether FIV crosses the intact vaginal and/or cervical mucous membrane by transcytosis in vivo; (2) to determine whether FIV infects cells within the epithelial layer as it ..
  40. MUCOSAL IMMUNITY AND INFECTION
    MICHAEL LAMM; Fiscal Year: 2004
    ..The insights to be gained from this PROGRAM Project may e broadly applicable since many infections involve mucous membranes, either as sites of infection or as portals of entry into the host. ..
  41. BMZ BIOLOGY AND PATHOLOGY IN EB SYMPOSIUM
    Jouni Uitto; Fiscal Year: 1991
    ..I believe that the planned symposium will be beneficial in defining the problems in EB, and will further enhance our understanding of the basement zone biology in general...
  42. Role of Pet Animals as Reservoirs for MRSA in Households
    Daniel Morris; Fiscal Year: 2009
    ..It is a fact that humans and animals share germs, such as MRSA. Recognizing this fact and discovering ways to minimize its impact is imperative to the protection of public health: both human and animal. ..
  43. ORAL CARCINOGENESIS, VITAMIN A AND RETINOIDS
    Gerald Shklar; Fiscal Year: 1980
    ..A or the synthetic retinoids administered systemically can act to delay or inhibit carcinogenesis of oral mucous membrane. Two well established oral mucosal tumor systems will be used: the hamster buccal pouch epidermoid carcinoma ..
  44. DNA Plasmid Mucosally Enhanced Anthrax Delivery Vaccine
    DEBRA TRANTOLO; Fiscal Year: 2002
    ..The Phase I feasibility will be defined by the capacity of the formulation to elicit antibody responses at a level sufficient to suggest protective efficacy against anthrax spore challenge. ..
  45. VIRAL & IMMUNE ELEMENTS IN EARLY PEDIATRIC HIV INFECTION
    Paul Palumbo; Fiscal Year: 1999
    ..vertical transmission of HIV from mother to infant requires passage through the placenta or the newborn skin/mucous membrane surface, both of which are remarkably effective in protecting the fetus/infant in the majority of cases...
  46. FINE STRUCTURE AND CHEMISTRY OF NERVE ENDINGS
    NIKOLAJS CAUNA; Fiscal Year: 1980
    ....
  47. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  48. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  49. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  50. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  51. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  52. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  53. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  54. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Functional Genomic Analysis of HIV-1 Infection in Lymphatic Tissues
    Ashley Haase; Fiscal Year: 2008
    ..Collectively, insights into pathological and reparative processes could lead to new approaches to decreasing the pathological consequences of infection and to new therapeutic strategies to enhance immune reconstitution. ..
  56. PATHOGENESIS OF HIV INDUCED IMMUNODEFICIENCY
    Ashley Haase; Fiscal Year: 2008
    ..abstract_text> ..
  57. PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATION
    Jiri Mestecky; Fiscal Year: 2006
    ..Results of these studies will generate information concerning previously unexplored inflammatory pathways that participate in the development of PD. ..
  58. PATHOGENESIS OF MUCOSAL TRANSMISSION/ACUTE SIV INFECTION
    Ashley Haase; Fiscal Year: 2003
    ..In aim 3, they will test the hypothesis that the balance between virus reproduction and the scope and breadth of the immune response determines the success or failure of establishing a persistent infection. ..