Genomes and Genes
Summary: A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX situated on each side of the fauces, between the anterior and posterior pillars of the soft palate (PALATE, SOFT).
Publications263 found, 100 shown here
- The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolyticGuido Ferlazzo
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Immunol 172:1455-62. 2004..These results also suggest secondary lymphoid organs as a possible site of NK cell differentiation and self-tolerance acquisition...
- Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitisAnne Mansson
Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
Respir Res 7:36. 2006..In the present study, the expression profile of TLR1-TLR10 was characterized in human tonsil T cells, focusing on differences between subsets of CD4+ T helper (Th) cells and CD8+ cytotoxic T lymphocytes (CTL)..
- Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entitySamir K El-Mofty
Washington University School of Medicine, St Louis, MO 63110, USA
Am J Surg Pathol 27:1463-70. 2003..The HPV-positive carcinomas have a distinct histopathologic and immunophenotypic features...
- Regulation of the tonsil cytokine milieu favors HIV susceptibilityNiki M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr, MSC 4352, Bethesda, MD 20892, USA
J Leukoc Biol 80:1145-55. 2006..To dissect the mechanisms underlying susceptibility to HIV in this compartment, isolated tonsil cells were studied for phenotypic and functional characteristics, which may account for their permissiveness to ..
- NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretionBarbara Morandi
Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
Eur J Immunol 36:2394-400. 2006..Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells via cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors...
- Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary reportMargaret J Lesmeister
Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, 1 Hospital Drive, M616 Medical Sciences Building, Columbia, MO 65212, USA
Int J Pediatr Otorhinolaryngol 70:987-92. 2006The Waldeyer's ring, comprised of the nasopharyngeal tonsil (adenoid), the paired tubal tonsils, the paired palantine tonsils, and the lingual tonsil, is arranged in a circular orientation around the wall of the throat...
- CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotidesFlorian Gantner
Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Diseases Research, Japan
Eur J Immunol 33:1576-85. 2003..We investigated the expression of the CpG receptor, Toll-like receptor 9 (TLR9), in human tonsil B cells, and determined functional responses following stimulation by a well-characterized stimulatory CpG-..
- Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markersChia Chi Ku
Department of Pediatrics, Stanford University, Stanford, California 94305, USA
J Virol 76:11425-33. 2002..The susceptibility of tonsil T cells to VZV suggests that these cells may be important targets during the initial VZV infection of upper ..
- Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responsesHyung W Lim
Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
J Clin Invest 114:1640-9. 2004..Our results have identified a subset of Tregs that is physiologically relevant to GC-Th cell-dependent B cell responses and a potential regulation mechanism for the trafficking of these Tregs to GCs...
- Classical swine fever virus induces activation of plasmacytoid and conventional dendritic cells in tonsil, blood, and spleen of infected pigsAgnès Jamin
French Agency for Food Safety AFSSA, Poultry and Swine Research Laboratory, Swine Virology Immunology Unit, BP 53, 22440 Ploufragan, France
Vet Res 39:7. 2008..Detection of antigen activated B lymphocytes in tonsil T-cell areas at 72 h pi, subsequently to the transient translocation of the viral E2 protein within germinal ..
- The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expressionFrancisco Medina
Servicio de Inmunologia, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009 Cadiz, Spain
Blood 99:2154-61. 2002..In addition, by using the common CD38(h) feature, human PCs from tonsil (as a possible source of early PCs), from blood from tet-immunized donors (as the putative precursors of BM PCs), ..
- Transcriptional analysis of the B cell germinal center reactionUlf Klein
Institute for Cancer Genetics and Department of Pathology, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:2639-44. 2003..These results provide insights into the dynamics of the GC reaction and represent the basis for the analysis of B cell malignancies...
- Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balanceAndrew D Hislop
Institute for Cancer Studies and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
J Clin Invest 115:2546-55. 2005..We therefore studied how responses localize to the tonsil, a major target site for EBV, during primary infection and persistence...
- Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting diseaseT R Spraker
Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA
J Vet Diagn Invest 14:3-7. 2002..The MAb F99/97.6.1 immunohistochemistry assay was evaluated in brain and tonsil tissue from 100 mule deer that had spongiform encephalopathy compatible with CWD and from 1,050 mule deer outside ..
- Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agentsAudrey Kinter
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, MSC 1576, Building 10, Room 6A33, 10 Center Drive, Bethesda, MD 20892 1576, USA
AIDS Res Hum Retroviruses 19:847-56. 2003..The ability of resting CD4+ T cells to support HIV replication in the microenvironment of the lymphoid tissue has implications in the pathogenesis of HIV disease and may provide an additional avenue for therapeutic intervention...
- Tonsil epithelial factors may influence oropharyngeal human immunodeficiency virus transmissionNiki M Moutsopoulos
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda 20892, USA
Am J Pathol 171:571-9. 2007b>Tonsil epithelium has been implicated in human immunodeficiency virus (HIV) pathogenesis, but its role in oral transmission remains controversial...
- Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte traffickingDiana Palmeri
Department of Anatomy and Program of Immunology, University of California, San Francisco, USA
J Leukoc Biol 75:910-27. 2004..novel HEC-specific proteins with potential function in the recruitment cascade, we sequenced a normalized human tonsil HEC cDNA library (generated from an inflamed tonsil) from which lymphocyte and human umbilical vein endothelial ..
- Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivoLauri L Laichalk
Dept of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave, Boston, MA 02111, USA
J Virol 79:1296-307. 2005....
- Development of the palatine tonsil in conventional and germ-free pigletsStephen Wilson
Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU, UK
Dev Comp Immunol 29:977-87. 2005..The results suggest that the microbial environment influences the development of the tonsil immunological architecture...
- Histamine reduces gap junctional communication of human tonsil high endothelial cells in cultureXavier F Figueroa
Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad, Catolica de Chile, Chile
Microvasc Res 68:247-57. 2004The regulation of gap junctional communication by histamine was studied in primary cultures of human tonsil high endothelial cells (HUTECs)...
- The correlation among obesity, apnea-hypopnea index, and tonsil size in childrenYuen Yu Lam
Department of Paediatrics, Kwong Wah Hospital, 25 Waterloo Road, Hong Kong SAR
Chest 130:1751-6. 2006..We hypothesized that there is a significant correlation between the degree of obesity and the severity of OSA in children...
- Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4Elizabeth J Ryan
Regional Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195, USA
J Immunol 169:5638-48. 2002..Therefore, the function of DCAL-1 on DCs and B cells may act as a T cell costimulatory molecule, which skews CD4(+) T cells toward a Th2 response by enhancing their secretion of IL-4...
- Higher maturity and connective tissue association distinguish resident from recently generated human tonsil plasma cellsFrancisco Medina
Servicio de Inmunología and Unidad de Investigación, Hospital Universitario Puerta del Mar, Cadiz, Spain
J Leukoc Biol 82:1430-6. 2007Human plasma cells (PC) are present in cell suspensions obtained from the tonsil by mechanical disaggregation (PC(MECH))...
- Human beta-defensins and toll-like receptors in the upper airwayS Claeys
Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
Allergy 58:748-53. 2003..In this study, the expression of human beta-defensins (HBD) 2 and 3 and toll-like receptors (TLR) 2 and 4 in various upper airway diseases was investigated...
- Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cellsAnna Corcione
Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
Int Immunol 14:883-92. 2002..MCP-2/CCL8, MCP-3/CCL7, eotaxin/CCL11 and macrophage-derived chemokine (MDC)/CCL22 on the locomotion of human tonsil B lymphocytes and their subsets...
- Comparison of histology between recurrent tonsillitis and tonsillar hypertrophyP C Zhang
Department of Otolaryngology, The National University of Singapore, Singapore
Clin Otolaryngol Allied Sci 28:235-9. 2003..It may also explain the difference in aetiology and/or immune defence mechanism underlying these two conditions...
- Rabbit tonsil-associated M-cells express cytokeratin 20 and take up particulate antigenAlessandro Carapelli
Dept of Pharmacology Giorgio Segre, Section of Morphology, Via Aldo Moro 4, University of Siena, Siena, Italy
J Histochem Cytochem 52:1323-32. 2004..was identified at 46 kD on samples of proteins from the intermediate filament-enriched cytoskeletal fraction of tonsil epithelium...
- Bacteriologic comparison of tonsil core in recurrent tonsillitis and tonsillar hypertrophyJin Hyeok Jeong
Department of Otolaryngology, College of Medicine, Hanyang University, Seoul, Korea
Laryngoscope 117:2146-51. 2007..The purpose of this study was to analyze the underlying bacterial pathogens in tonsillar disease...
- Sustained secretion of immunoglobulin by long-lived human tonsil plasma cellsJacob M van Laar
B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Pathol 171:917-27. 2007..Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion...
- Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patientsCorrado Blandizzi
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University Hospital of Pisa, Pisa, Italy
Antimicrob Agents Chemother 46:1594-6. 2002..Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose...
- A case of unexpected difficult airway due to lingual tonsil hypertrophyH Asbjørnsen
Department of Anaesthesia and Intensive Care Medicine, Haukeland University Hospital, Bergen, Norway
Acta Anaesthesiol Scand 52:310-2. 2008Clinical value of preoperative bedside screening tests for predicting difficult airway remains limited. Asymptomatic lingual tonsil hypertrophy is a known cause of unexpected difficult airway. We report a case as a reminder of this.
- Complete upper airway obstruction after induction of anesthesia in a child with undiagnosed lingual tonsil hypertrophyMauro Arrica
Department of Anesthesia, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Paediatr Anaesth 16:584-7. 2006We present a case of a 9-year-old patient with previously undiagnosed lingual tonsil hypertrophy (LTH) that caused sudden and complete airway obstruction and inability to ventilate on induction of anesthesia...
- Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivoSalim Bounou
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Hôpital CHUL, Ste Foy, Quebec G1V 4G2, Canada
J Virol 76:1004-14. 2002....
- Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell developmentFenghuang Zhan
Donna and Donald Lambert Laboratory of Myeloma Genetics at the Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Blood 101:1128-40. 2003..0005) identified 359 and 500 previously defined and novel genes that distinguish tonsil BCs from tonsil PCs (early differentiation genes [EDGs]), and tonsil PCs from bone marrow PCs (late ..
- CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell folliclesMaire F Quigley
Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Eur J Immunol 37:3352-62. 2007..CXCR5+ CD8 T cells were found in tonsil B cell follicles, and isolated cells migrated towards CXCL13 in vitro...
- Detection of Helicobacter pylori and its CagA gene in tonsil and adenoid tissues by PCRMeltem Yalinay Cirak
School of Medicine, Department of Microbiology and Clinical Microbiology, Gazi University, Ankara, Turkey
Arch Otolaryngol Head Neck Surg 129:1225-9. 2003..To determine the presence of Helicobacter pylori and, if detected, the prevalence of the CagA gene in adenotonsillectomy specimens by polymerase chain reaction (PCR)...
- Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL populationTonia Woodberry
Partners AIDS Research Center, Massachusetts General Hospital, Boston 02129, USA
J Immunol 175:4355-62. 2005..EBV-specific, tonsil-resident, but not PBMC-derived, T cells expressed the integrin/activation marker CD103 (alphaEbeta7), consistent ..
- Ex vivo modeling of oral HIV transmission in human palatine tonsilDiane M Maher
Department of Microbiology, MMC 196, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Histochem Cytochem 53:631-42. 2005..By using human palatine tonsil from routine tonsillectomies and semen from HIV-positive donors, we have created an experimental equivalent to ..
- Interactions between Streptococcus suis serotype 2 and cells of the myeloid lineage in the palatine tonsil of the pigStephen M Wilson
School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU, United Kingdom
Vet Immunol Immunopathol 117:116-23. 2007..The palatine tonsil is one of the main sites where the organism can be recovered, both in infected and carrier animals...
- The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epitheliumAndrew C Hoover
Department of Otolaryngology Head and Neck Surgery, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Arch Otolaryngol Head Neck Surg 133:495-502. 2007..To provide a manipulatable system to study the mechanism of human papillomavirus 16 (HPV16) E6-related transformation of an epithelial cell type affected by HPV16 in humans...
- HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivoAnnette Audigé
Division of Infectious Diseases and Hospital Epidemiology, Institute of Clinical Immunology, and Clinic of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
J Immunol 172:2687-96. 2004..These results also indicate that different molecular mechanisms govern HIV replication in tissue blocks and HLAC. Prevention of effective cytokine responses may be an important mechanism that HIV uses during acute infection...
- Transmission of chronic wasting disease of mule deer to Suffolk sheep following intracerebral inoculationAmir N Hamir
National Animal Disease Center, Agricultural Research Center, U S Department of Agriculture, Ames, IA 50010, USA
J Vet Diagn Invest 18:558-65. 2006..These findings demonstrate that transmission of the CWDmd agent to sheep via the intracerebral route is possible. Interestingly, the host genotype may play a notable part in successful transmission and incubation period of CWDmd...
- Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cellsWilliam C Spanos
Department of Otolaryngology Head and Neck Surgery, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
Head Neck 30:139-47. 2008..Human papillomavirus 16 (HPV16) has been associated with head and neck squamous cell carcinoma (HNSCC) in up to 60% of sampled specimens...
- Pathogenesis of experimental bovine spongiform encephalopathy: preclinical infectivity in tonsil and observations on the distribution of lingual tonsil in slaughtered cattleG A H Wells
Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey
Vet Rec 156:401-7. 2005..at stages of pathogenesis previously indicated by mouse bioassay, traces of infectivity were found in the palatine tonsil of cattle killed 10 months after exposure...
- Germinal centers regulate human Th2 developmentBengt Johansson-Lindbom
Department of Immunotechnology, Lund University, Lund, Sweden
J Immunol 171:1657-66. 2003In the present study we demonstrate that all CD4(+) T cells in human tonsil expressing the Th2-selective receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) also 1) express high levels of CXCR5, and 2) ..
- Solitary fibrous tumor with atypical histological features occurring in the palatine tonsil: an uncommon neoplasm in an uncommon siteRicardo Silvestre Macarenco
Department of Pathology, Faculdade de Medicina de Botucatu, State University of Sao Paulo, Botucatu SP, Brazil
J Oral Pathol Med 35:602-5. 2006..We report the first case of a SFT arising from the palatine tonsil of a 62-year-old man...
- Distribution and phenotype of Epstein-Barr virus-infected cells in human pharyngeal tonsilsS David Hudnall
Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
Mod Pathol 18:519-27. 2005..non-B cells, the immunophenotype of all EBV-infected cells in reactive human tonsils was determined by subjecting tonsil sections to dual/triple EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (..
- Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skinEmily L Abbot
Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Cell Microbiol 9:1822-33. 2007..pyogenes strain SF370 to both human tonsil epithelium and primary human keratinocytes, which represent the two main sites of infection by this human-specific ..
- Obese obstructive sleep apnea patients with tonsil hypertrophy submitted to tonsillectomyF L Martinho
Departamento de Otorrinolaringologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
Braz J Med Biol Res 39:1137-42. 2006..e., obese OSAHS patients with tonsil hypertrophy...
- Tonsil size and body mass index are important factors for efficacy of simple tonsillectomy in obstructive sleep apnoea syndromeS Nakata
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Clin Otolaryngol 31:41-5. 2006..To evaluate the efficacy of simple tonsillectomy to treat obstructive sleep apnoea syndrome (OSAS) in adults...
- [Report of a case: large tonsillolith in palatine tonsil]F J Cogolludo Pérez
Servicio de ORL, Hospital Clinico San Carlos, Madrid
Acta Otorrinolaringol Esp 53:207-10. 2002A 69-year-old woman presented with a one-year history of dysphagia and a hard overgrowth of the right palatine tonsil visible in oral examination...
- Extramedullary plasmacytoma of the tonsil diagnosed by fine-needle aspiration cytologyYu Sakai
Department of Pathology, Japan Self Defense Forces Sapporo General Hospital, Hokkaido 062 8610, Japan
Ann Diagn Pathol 12:41-3. 2008..Examination of the oral cavity showed enlargement of the left tonsil. Magnetic resonance imaging demonstrated a solid mass, measuring 3.2 x 2.0 x 3.8 cm, in the left tonsil...
- Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriersDirk M Pegtel
Department of Pathology, Tufts University School of Medicine, Jaharis Bldg, 150 Harrison Avenue, Boston, MA 02111, USA
J Virol 78:12613-24. 2004..In this report, we show the establishment and characterization of an ex vivo culture model of tonsil epithelial cells, a likely site for EBV infection in vivo...
- Determination of in vivo protein synthesis in human palatine tonsilAnna Januszkiewicz
Department of Anaesthesiology and Intensive Care, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
Clin Sci (Lond) 108:179-84. 2005..The aim of the present study was to investigate if the immunological activation of the human palatine tonsil is reflected by a high metabolic activity, as determined by in vivo measurement of protein synthesis...
- Detection of the archetypal regulatory region of JC virus from the tonsil tissue of patients with tonsillitis and tonsilar hypertrophyAtsushi Kato
Department of Urology, Mitsui Memorial Hospital, Tokyo, Japan
J Neurovirol 10:244-9. 2004..Nevertheless, Monaco et al (J Virol 70: 7004-7012, 1996) reported that PML-type regulatory regions occur in human tonsil tissue. The purpose of this study is to confirm their findings...
- Quantitative cytokine gene expression in human tonsils at excision and during histoculture assessed by standardized and calibrated real-time PCR and novel data processingAthos Bonanomi
Division of Infectious Diseases, University Children s Hospital of Zurich, Zurich, Switzerland
J Immunol Methods 283:27-43. 2003..b>Tonsil histocultures could serve as a valuable ex vivo model system for further, donor-dependent, studies on activation ..
- Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2Shao Heng He
Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
Acta Pharmacol Sin 26:568-74. 2005..To investigate the effects of the agonists of proteinase activated receptor (PAR)-2, and histamine on degranulation of human mast cells...
- Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting diseaseKatherine I O'Rourke
Agricultural Research Service, U S Department of Agriculture, Animal Disease Research Unit, Pullman, WA 99164, USA
J Vet Diagn Invest 15:320-3. 2003A monoclonal antibody dot-blot assay was used to evaluate detergent lysates of tonsil tissue from mule deer to detect PrP(CWD), the marker for the cervid transmissible spongiform encephalopathy chronic wasting disease (CWD)...
- The dispersal of mucosal memory B cells: evidence from persistent EBV infectionLauri L Laichalk
Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Immunity 16:745-54. 2002..This pathway may reflect that of normal memory B cells derived from nasopharyngeal and other mucosal lymph nodes...
- Rapid PrP(Sc) detection in lymphoid tissue and application to scrapie surveillance of fallen stock in Japan: variable PrP(Sc) accumulation in palatal tonsil in natural scrapieKimi Shimada
Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan
Microbiol Immunol 49:801-4. 2005..In this program, brain and palatal tonsil were examined by WB and three cases of sheep scrapie were detected...
- HIV-gp160 modulates differentially the production in vitro of IgG, IgA and cytokines by blood and tonsil B lymphocytes from HIV-negative individualsF Cognasse
GIMAP EA3064, Universite de Saint Etienne, Faculte de Medecine, Saint Etienne, France
Clin Exp Immunol 132:304-8. 2003..Gp160 induced significantly less total IgG by blood - but not tonsil-originating - B cells and did not affect total IgA production...
- A model system of oral HIV exposure, using human palatine tonsil, reveals extensive binding of HIV infectivity, with limited progression to primary infectionDiane Maher
Department of Microbiology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Infect Dis 190:1989-97. 2004..We developed a mucosal model, using human palatine tonsil with intact external epithelium, to study events after oral exposure to HIV...
- Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sectionsKunihiko Maeda
Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
J Histochem Cytochem 50:1475-86. 2002..Our results are easily adaptable for routine practice and provided useful suggestions concerning the immunopathological behavior and diversity of the particular cells...
- Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissueG R Kolar
Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104a, USA
Scand J Immunol 64:314-24. 2006..representation of naïve and germinal centre B-cell subpopulations changed relative to total B lymphocytes in the tonsil. While the percentage of naïve and germinal centre B-cell subpopulations changes during the second half of life, ..
- Biofilm formation by Haemophilus influenzae isolated from adeno-tonsil tissue samples, and its role in recurrent adenotonsillitisJ Galli
Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy
Acta Otorhinolaryngol Ital 27:134-8. 2007..with a morphology consistent with bacterial coccoid biofilms, were observed in all adenoid (15/15) and in 6/10 tonsil samples...
- Streptococcal modulation of cellular invasion via TGF-beta1 signalingBeinan Wang
Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, MMC 196, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 103:2380-5. 2006..of TGF-beta1 to up-regulate integrin expression and intracellular invasion by GAS was reproduced in primary human tonsil fibroblasts, which could be a source of TGF-beta1 in chronically infected tonsils...
- Heterogeneity of freshly isolated human tonsil dendritic cells demonstrated by intracellular markers, phagocytosis, and membrane dye transferGianna Stent
Department of Microbiology and Immunology, University of Melbourne, Grattan Street, Parkville, Australia
Cytometry 48:167-76. 2002..Heterogeneity within human dendritic cells (DCs) has been described but its functional relationships to cells of macrophage lineage and its role in human immunodeficiency virus (HIV) infection in vivo remain unclear...
- The unexpected difficult airway and lingual tonsil hyperplasia: a case series and a review of the literatureAndranik Ovassapian
Department of Anesthesia and Critical Care, The University of Chicago Hospitals, University of Chicago, Illinois 60637, USA
Anesthesiology 97:124-32. 2002..Lingual tonsil hyperplasia (LTH) is one risk factor for an unanticipated failed intubation that is not detectable during a ..
- [Extramedullary plasmocytoma of the left tonsil. A rare cause of tonsillar asymmetry]T Zehlicke
Abteilung für Hals Nasen Ohrenheilkunde des Bundeswehrkrankenhauses Hamburg
HNO 50:240-3. 2002..First of all, squamous-cell carcinoma has to be taken into account, more rarely with malignant lymphoma. Tonsillektomie added by immunhistological examination of the preparation brings diagnostic certainty...
- [A preliminary study on the immune suppressive protein of stress in human tonsil]Jie Zhang
Department of Physiology, The Health Science Center of Peking University, Beijing 100083
Sheng Li Xue Bao 54:171-4. 2002..In the present work, a protein similar to ISPS was found in human tonsil (a peripheral lymph tissue). Human tonsil was homogenized and the extract was prepared...
- Expression of chemokine receptors in normal and inflamed human intestine, tonsil, and liver--an immunohistochemical analysis with new monoclonal antibodies from the 8th international workshop and conference on human leucocyte differentiation antigensFrank Autschbach
Institute of Pathology, University of Heidelberg, Heidelberg, Germany
Cell Immunol 236:110-4. 2005..by the cytokine/chemokine receptor section of the 8th HLDA workshop on cryostat sections of normal human gut, tonsil, and liver...
- Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding proteinChang Hoon Lee
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:63-72. 2006..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
- Germinal center B cells constitute a predominant physiological source of IL-4: implication for Th2 development in vivoBengt Johansson-Lindbom
Department of Immunotechnology, Lund University, Lund, Sweden
J Immunol 168:3165-72. 2002..In this report, we describe the anatomical localization as well as the identity of IL-4-producing cells in human tonsil, a representative secondary lymphoid organ...
- The human marginal zone B cellMariella Dono
Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
Ann N Y Acad Sci 987:117-24. 2003..If the current distinction into B1 and B2 cells has to be maintained also for humans, it is likely that only these CD5-positive cells rather than the FM B cells should be called B1 cells...
- Simultaneous, clonally identical T cell expansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitisMitsuhiro Kawano
Kanazawa Social Insurance Hospital, Kanazawa, Japan
Arthritis Rheum 48:2483-8. 2003..Analysis of infiltrating T cell clones in tonsil and synovium using T cell receptor V(beta) repertoire and third complementarity-determining region size ..
- Temperature-controlled radiofrequency tonsil reduction in childrenLionel M Nelson
Arch Otolaryngol Head Neck Surg 129:533-7. 2003To evaluate the safety and efficacy of temperature-controlled radiofrequency tonsil reduction in the treatment of children with a sleep-related breathing disorder associated with tonsillar obstructive hypertrophy.
- Long-term effects of pediatric adenotonsillectomy on serum immunoglobulin levels: results of a randomized controlled trialEmma H van den Akker
Department of Otorhinolaryngology, Wilhelmina Children s Hospital University Medical Center Utrecht, The Netherlands
Ann Allergy Asthma Immunol 97:251-6. 2006....
- The effects of tonsillectomy and adenoidectomy on pulmonary arterial pressure in childrenMustafa Deniz Yilmaz
Department of Otolaryngology Head and Neck Surgery, Afyon Kocatepe University, Afyon, Turkey
Am J Otolaryngol 26:18-21. 2005....
- Effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy: open, randomised controlled trialBirgit K van Staaji
Clin Otolaryngol 30:60-3. 2005..To assess the effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy...
- [Snoring in children]M Francois
Service ORL, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, 48, boulevard Serurier, 75935 Paris Cedex 19, France
Arch Pediatr 13:207-10. 2006..Snoring is severe when associated with sleep apneas. The 3 most frequent causes of snoring in children are enlarged adenoids, enlarged tonsils and blocked nose due to allergic rhinitis...
- Children with obstructive sleep-disordered breathing generate high-frequency inspiratory sounds during sleepChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
Sleep 27:1154-61. 2004..Our objective was to determine whether HFIS occur in most children with obstructive SDB and adenotonsillar hypertrophy and whether adenotonsillectomy reduces HFIS...
- Optimal site for throat culture: tonsillar surface versus posterior pharyngeal wallE L van der Veen
Department of Otorhinolaryngology E 04 140 5, Wilhelmina Children s Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands
Eur Arch Otorhinolaryngol 263:750-3. 2006..When detection of other bacteria is also important, such as for research purposes, the posterior pharyngeal wall should be sampled as well...
- Changes in behavior and attentional capacity after adenotonsillectomyBarbara C Galland
Department of Women s and Children s Health, University of Otago, Dunedin, New Zealand
Pediatr Res 59:711-6. 2006....
- Temperature-controlled radiofrequency treatment of tonsillar hypertrophy for reduction of upper airway obstruction in pediatric patientsJames M Coticchia
Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Arch Otolaryngol Head Neck Surg 132:425-30. 2006To determine if temperature-controlled radiofrequency (TCRF) tonsil reduction and adenoidectomy (TCRF&A) and conventional tonsillectomy and adenoidectomy (T&A) are statistically similar in outcome and to compare morbidity between ..
- Growth failure and sleep disordered breathing: a review of the literatureKaren Bonuck
Department of Epidemiology and Population Health, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467 2490, USA
Int J Pediatr Otorhinolaryngol 70:769-78. 2006....
- Improved somatic growth following adenoidectomy and tonsillectomy in young children. Possible pathogenetic mechanismsHarilaos S Vontetsianos
ENT Department, First Paediatric Department, Athens University, Children s Hospital, Agia Sophia Athens, Greece
Hormones (Athens) 4:49-54. 2005..All other metabolic indices did not change. In conclusion, linear grow post-Adenotonsillectomy improved in children aged <5 years and was associated with improved with IGF-1/GH ratio, increased Hbeta values and decreased in WBC...
- The effects of chin lift and jaw thrust while in the lateral position on stridor score in anesthetized children with adenotonsillar hypertrophyYoung Chang P Arai
Department of Anesthesiology, Kochi Medical School, Oko cho, Nankoku, Kochi, 783 8505, Japan
Anesth Analg 99:1638-41, table of contents. 2004..We conclude that lateral positioning combined with airway maneuvers significantly improved airway patency compared with the airway maneuvers alone for patients in the supine position...
- Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apneaAviv D Goldbart
Department of Pediatrics, Kosair Children s Hospital Research Institute, and Department of Surgery, Division of Ear Nose and Throat, University of Louisville, Louisville, Kentucky 40202, USA
Pediatr Res 62:489-94. 2007....
- Upper airway dynamic responses in children with the obstructive sleep apnea syndromeCarole L Marcus
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287, USA
Pediatr Res 57:99-107. 2005..Further, we speculate that this compensatory response is lacking in children with OSAS, most likely due to either habituation to chronic respiratory abnormalities during sleep or to mechanical damage to the upper airway...
- Alteration of adenoid tissue alkaline and acid phosphatase in children with secretory otitis mediaSnezana Jesic
Institute for Otorhinolaryngology and Maxillofacial surgery, Clinical Centre of Serbia, 11000 Belgrade, Pasterova 2 Street, Serbia and Montenegro
Int J Pediatr Otorhinolaryngol 70:1069-76. 2006..Specific activity and kinetic properties were studied in palatinal tonsils and adenoids of children with secretory otitis (OME) and compared with children with recurrent tonsillitis without ear involvement...
- Post-tonsillectomy morbidity and quality of life in pediatric patients with obstructive tonsils and adenoid: microdebrider vs electrocauteryCraig S Derkay
Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, 825 Fairfax Avenue, Ste 510, Norfolk, VA 23507 1914, USA
Otolaryngol Head Neck Surg 134:114-20. 2006..To prospectively compare outcomes in children over age 2 with obstructive adenotonsillar hypertrophy when tonsillectomy is performed utilizing an intracapsular microdebrider technique versus low-wattage electrocautery technique...
- Is diagnostic tonsillectomy indicated in all children with asymmetrically enlarged tonsils?Anton C van Lierop
Division of Otorlaryngology, University of Cape Town, South Africa
S Afr Med J 97:367-70. 2007....
- Changes in growth pattern, body composition and biochemical markers of growth after adenotonsillectomy in prepubertal childrenBetul Ersoy
Celal Bayar University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Manisa, Turkey
Int J Pediatr Otorhinolaryngol 69:1175-81. 2005..The aim of this study was to determine the changes in growth, body composition and biochemical markers associated with growth following adenotonsillectomy (A&T) in prepubertal children...
- Oxidants and antioxidants in tonsillar and adenoidal tissue in chronic adenotonsillitis and adenotonsillar hypertrophy in childrenA Faruk Kiroglu
Yuzuncu Yil University, School of Medicine, Department of Otolaryngology, Van, Turkey
Int J Pediatr Otorhinolaryngol 70:35-8. 2006..The aim of the study is to determine the possible role of oxidants and antioxidants in the pathogenesis of chronic adenotonsillitis and adenotonsillar hypertrophy in children...
- Pathologic evaluation of routine tonsillectomy and adenoidectomy specimens in the pediatric population: is it really necessary?Taner K Erdag
Dokuz Eylul University School of Medicine, Department of Otolaryngology, Izmir, Turkey
Int J Pediatr Otorhinolaryngol 69:1321-5. 2005..To evaluate the necessity of histopathologic examination for routine tonsillectomy and/or adenoidectomy in terms of unexpected malignancy by evaluating a large group of pediatric patients retrospectively with review of the literature...
- Tonsillitis index: an objective tool for quantifying the indications for tonsillectomy for recurrent acute tonsillitisKeiji Fujihara
Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
Int J Pediatr Otorhinolaryngol 69:1515-20. 2005..TI may be a useful tool for surgical decision making...
- Cytokines locally produced by lymphocytes removed from the hypertrophic nasopharyngeal and palatine tonsilsAnna Komorowska
Department of Otolaryngology, Polish Mother s Memorial Hospital, Research Institute, Lodz, Poland
Int J Pediatr Otorhinolaryngol 69:937-41. 2005Human palatine tonsils and the nasopharyngheal tonsil are the largest components of the Waldeyer's ring...
- The effect of adenotonsillectomy on oxygen saturation in children with sleep breathing disordersJaime Arrarte
Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Pos graduate Program, Brazil
Int J Pediatr Otorhinolaryngol 71:973-8. 2007..To evaluate the effect of adenotonsillectomy on the oxygen saturation measures by nocturnal pulse oximetry in children with sleep breathing disorders (SBD)...
- Tonsillar colonization is unlikely to play important role in Helicobacter pylori infection in childrenBoris Jelavic
Department of Otorhinolaryngology, Mostar University Hospital, Mostar, Bosnia and Herzegovina
Int J Pediatr Otorhinolaryngol 71:585-90. 2007....
- Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomyRiva Tauman
Kosair Children s Hospital Research Institute and the Department of Pediatrics, Division of Pediatric Sleep Medicine, University of Louisville, Louisville, Kentucky, USA
J Pediatr 149:803-8. 2006..To investigate the relative contribution of various risk factors to the surgical outcome of adenotonsillectomy for obstructive sleep apnea syndrome in children...
- [Muramidase and lactoferrin in adenoidal hypertrophies, hypertrophic and chronic infected tonsil tissue--a quantitative analysis]M Schwaab
Universitätsklinik für Hals Nasen Ohrenheilkunde und Kopf und Halschirurgie, Ruhr Universitat Bochum
Laryngorhinootologie 84:660-4. 2005..Till now there are only immunohistochemical and microbiological studies on the presence of muramidase and lactoferrin in adenoid and tonsil tissue available.
- HOST IMMUNITY TO EBV INFECTION IN VITRO AND IN VIVODavid A Thorley-Lawson; Fiscal Year: 2013..To test this we will show that: 1. P. falciparum activates AID in vitro. Tonsil B cells will be cultured with various AID agonists combined with parasite preparations including whole extracts ..
- Varicella-Zoster Virus: T Cell/Skin Tropism &ImmunityAnn Arvin; Fiscal Year: 2013..VZV infects human tonsil T cells very efficiently and infected tonsil T cells transfer VZV into skin xenografts, where lesion formation ..
- Role of HSF1 in B cell activation and lymphomaTharu M Fernando; Fiscal Year: 2013..is induced in the GC response and DLBCL via HSF1 ChIP-seq and gene expression analysis (mRNA-seq) in normal human tonsil-derived na?ve and GC B cells and in malignant human DLBCL cell lines and primary DLBCL patient samples...
- Plasmacytoid Dendritic Cells in HIV PathogenesisPatricia Fitzgerald-Bocarsly; Fiscal Year: 2013..blood of HIV-infected patients;second, we will determine whether pDC:HIV-infected T cell fusion occurs in tonsil suspension cells and tonsil organ culture;third, in collaboration with Dr...
- Integrative epigenomic/genomic profiling and biomarker discovery in HPV+ and HPV-MAUREEN AGNES SARTOR; Fiscal Year: 2013..Currently, treatment of head and neck SCC (HNSCC) is not based on HPV status. The incidence of tonsil and tongue cancers have been increasing annually and many contain high risk HPV...
- Virus-Host Cell Interactions in AIDS-Associated PMLWalter Atwood; Fiscal Year: 2013..First, the anatomical site of virus latency is not known but kidney, tonsil, bone marrow, and brain have all been postulated to be involved...
- HIV-Induced CD4 T-Cell Depletion: An Innate Host Defense Gone Awry?Warner C Greene; Fiscal Year: 2013..Using primary human lymphoid aggregate cultures (HLAC) formed with tonsil or spleen tissue, we have explored how CD4 T cells die during HIV infection in lymphoid tissues...
- Augmenting Innate Immunity to Protect the Oral MucosaMark C Herzberg; Fiscal Year: 2013..cytotoxic, proinflammatory immune, and carcinogenic side effects, we will concurrently model this system in human tonsil explants ex vivo...
- Determining Whether Transient HIV Infection OccursMiles W Cloyd; Fiscal Year: 2010..HIV was found by PCR in the tonsil of one such transiently HIV infected subject, but it was not detected in the PBMCs...
- THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITYMarco Colonna; Fiscal Year: 2013..We recently discovered a novel subset of tonsil and gut innate immune cells that express natural killer (NK) cell markers, but, in contrast to conventional NK ..
- Adenovirus Persistence in Human Lymphoid TissuesLinda Gooding; Fiscal Year: 2007..real time PCR assay that detects adenoviral DNA in mononuclear cell preparations from the majority (81%) of tonsil and adenoid specimens tested...
- STRUCTURE AND GENETIC CONTROL OF IGAKatherine Knight; Fiscal Year: 2000..assays, most of the 13 C/a genes are known to be expressed in gut-associated lymphoid tissue, but in lung and tonsil of the respiratory tract, only one C/a gene, C/a4 is expressed...
- Intercellular communication in Epstein Barr virus reactivationErik K Flemington; Fiscal Year: 2013..This model proposes that environmental cues from the oral/tonsil epithelium (in the late stages of the germinal center reaction, for example) trigger reactivation in B-cells, ..
- IMMUNOLOGICAL ASPECTS OF RETINOIDS IN HUMAN CANCERNeil Sidell; Fiscal Year: 1993..the effects of RA along with various activation\growth signals on the differentiation and the secretion from fresh tonsil lymphocytes...
- Pathogenesis of Oropharyngeal HHV-8 InfectionAndrew Johnson; Fiscal Year: 2005..that the frequency of HHV-8 shedding in saliva is increased in the presence of HIV infection, with lingual and tonsil swabs demonstrating the highest viral titers. Salivary glands do not appear to be a significant source of HHV-8...
- Tonsil Model of Oral HIV-1 Infection via BreastfeedingDiane Shugars; Fiscal Year: 2003..This exploratory study will develop and characterize a human tonsil histoculture model of oral HIV-1 acquisition through breast milk...
- EFFECTS OF TONSIL-ADENOID SURGERY ON THROAT INFECTIONJACK PARADISE; Fiscal Year: 1990..Enrollment of subjects through August 1986 and follow-up through August, 1989 appears necessary to achieve results sufficiently conclusive to be persuasive to clinicians and to influence well-established standards of practice...
- Oral HIV Pathogenesis and SheddingRobert Coombs; Fiscal Year: 2005..06). HIV was not isolated from saliva, buccal or salivary mucosa. Biopsies of palatine and lingual tonsil (n=6) revealed vRNA and p24 antigen within lymphoid follicles, despite HAART-suppressed plasma VL...
- Ultrasound-Mediated Tissue PreservationWei Sing Chu; Fiscal Year: 2003..Using this technique, we have demonstrated in lung and tonsil tissues that 1) the time of preservation is reduced from 24-48 hours to < 1 hour, 2) tissue morphology remains ..
- DENDRITIC CELLS AND HIV-1 PATHOGENESISRalph Steinman; Fiscal Year: 1999..have visualized production infection of dendritic cells, including syncytia derived from dendritic cells in the tonsil and adenoid mucosia of 13 of 13 specimens from HIV-1 infected individuals, most of them asymptomatic...
- ORAL TRANSMISSION OF SIV IN NEONATAL AND ADULT MACAQUESSHAWN O NEIL; Fiscal Year: 2004..that transmission will occur at multiple sites within the alimentary tract, including the lymphoepithelium of the tonsil, the respiratory mucosa of the nasopharynx, and the columnar epithelium of the gastrointestinal tract...
- Oral-Pharyngeal HHV-8 InfectionJeffrey Vieira; Fiscal Year: 2004..concentrations of HHV-8 in saliva are higher in individuals with concurrent HIV infection and that swabs from the tonsil and lingual surfaces appear to contain the highest titers of virus...
- Genomic and Proteomic Analysis of HPV-Associated SCCHNSaleem Khan; Fiscal Year: 2009..Since the majority of HPV-associated SCCHN arise in the oropharynx (tonsil and base of tongue), we will specifically analyze tumors from this sub-site...
- 5-LIPOXYGENASE STRUCTURE/FUNCTION IN MUCOSAL EPITHELIUMThomas Brock; Fiscal Year: 2001..The specific aims of this project are 1) to isolate and characterize the gene for the tonsil 5-LO enzyme, as well as its regulatory region, 2) to determine the properties of this novel 5-LO, with emphasis on ..
- CATALYTIC ANTIBODIES FOR HIV1 IMMUNOTHERAPYSudhir Paul; Fiscal Year: 1999..mechanism of neutralization and to approximate in vivo HIV-1 infection, including assay of neutralization using tonsil histoculture and SCID mouse models...
- Determining Whether Transient HIV Infection OccursMiles Cloyd; Fiscal Year: 2004..HIV was found by PCR in the tonsil of one such transiently HIV infected subject, but it was not detected in the PBMCs...
- HIV-1 Clones with Attenuated Cytopathic EffectsDavid Camerini; Fiscal Year: 2004..Characterize the replication and cytopathic effects, of R5 HIV-1 isolates from LTNP-HVL in FTOC, tonsil histoculture and SCID-hu mice...
- VALIDATION OF A DISEASE SPECIFIC HEALTH STATUS INSTRUMENMichael Stewart; Fiscal Year: 1999..No studies have evaluated the impact of tonsil and adenoid (T and A) disease on the health status or quality of life (QOL) of affected children...
- T CELL IMMUNITY AT ORAL VERSUS OTHER MUCOSAL SITESSTEVEN LONDON; Fiscal Year: 2002..We have demonstrated reovirus-specific immunity in the murine tonsil equivalent (Nasal Associated Lymphoid Tissue), salivary glands, and associated lymph nodes...
- Oral HIV Exposure May Result in Transient InfectionMiles Cloyd; Fiscal Year: 2004..HIV was found by PCR in the tonsil of one such transiently HIV infected subject, but it was not detected in the PBMCs...
- EPIDEMIOLOGY/MOLECULAR VIROLOGY OF ORAL HIV TRANSMISSIONTimothy Schacker; Fiscal Year: 2002..Animal data suggests of tonsil tissue can be easily infected with SIV and some observational studies suggest the rate of oral transmission may be ..
- MECHANISMS OF HEV CELL RECOGNITION OF APOPTOTIC CELLSJoan Cook Mills; Fiscal Year: 2000..Primary cultures of human tonsil HEV cells will be used to determine whether HIV survives HEV cell phagocytosis of apoptotic HIV-infected ..
- CHIMERIC MRNA TEMPLATES DRIVE AIDS B CELL LYMPHOMASAndrew Saxon; Fiscal Year: 1999..SCID mice will be reconstituted with human tonsil B cells carrying u: c myc constructs that drive u: c myc rearrangement (Aim 1)...
- Does the HSV-1 latency associated transcript (LAT) encode a protein?Clinton Jones; Fiscal Year: 2008..Studies will also determine whether LAT encoded proteins inhibit apoptosis, and whether these proteins are necessary for the latency reactivation cycle. [unreadable] [unreadable] [unreadable]..
- NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAYRALPH FREGOSI; Fiscal Year: 2002..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
- IL-15 Characterization Through Experimental ImmunologyMichael Caligiuri; Fiscal Year: 2009..abstract_text> ..
- PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEACAROLE MARCUS; Fiscal Year: 2008..These studies will help elucidate the pathophysiology of OSAS in obese adolescents, ultimately resulting in improved management of this disease. ..
- GENES INVOLVED IN AIDS LYMPHOMAGENESISMichael Teitell; Fiscal Year: 2002..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..
- Cancer and Non-cancer Mortality in Meat Workers (1 RO1-OH 008687-01 A1 SOH)Eric Johnson; Fiscal Year: 2008..Infectious disease is a NIOSH priority area. [unreadable] [unreadable] [unreadable]..
- THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMAMichael Caligiuri; Fiscal Year: 2002..The limitations of the animal model preclude its use for studying the pathogenesis of AIDS PCNSL. ..
- POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCEREric Johnson; Fiscal Year: 2002..The confirmed demonstration of ALSV pro-viral DNA in the genome of exposed tumor samples but not in that of control tumor samples, will provide definitive evidence incriminating ALSV in human carcinogenesis. ..
- LIPOSOMAL S MUTANS DELIVERY SYSTEM FOR CARIES IMMUNITYNoel Childers; Fiscal Year: 2001....
- PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCERALPH FREGOSI; Fiscal Year: 2008..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
- Noninvasive Ventilation in Children with Cystic FibrosisCAROLE MARCUS; Fiscal Year: 2004..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
- MOLECULAR GENETICS OF A SYNDROME WITH HEARING IMPAIRMENTJ Post; Fiscal Year: 2004..The delineation of the panoply of genes involved in causing craniosynostosis will enhance our understanding of these diseases and suggest new therapeutic strategies. ..
- P20-Mediated Suppression of Vascular ForceChristopher Rembold; Fiscal Year: 2004..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
- Polyamines and Breast Cancer BiologyAndrea Manni; Fiscal Year: 2005..The ultimate goal of these studies is to identify critical signaling molecules which can be targeted in conjunction with antipolyamine therapy to optimize prevention of metastasis from breast cancer. ..
- NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLEChristopher Rembold; Fiscal Year: 2004....
- Neurofeedback functional MRISeung Schik Yoo; Fiscal Year: 2006....
- Multimodal Imaging of the Sensory Gating Deficit in Chronic Cocaine AbusersANDREW MAYER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- B cell functional and signaling abnormalities in SLEJennifer Anolik; Fiscal Year: 2006..abstract_text> ..
- Oral Exposure and Transmission of HIVPeter Southern; Fiscal Year: 2003..Oral exposure to semen from HIV seropositive donors can lead to primary HIV infection. Tonsil organ culture systems have been developed in order to investigate the cellular and molecular mechanisms that ..
- Pneumococcal Biofilms in Otitis MediaJames Post; Fiscal Year: 2007..Delineating the molecular basis of biofilms will not only advance our understanding of OM, but of chronic infectious disease in general. ..
- A Novel Model for the Study of Lung Pathogenesis of SARSLinqi Zhang; Fiscal Year: 2008..These methods are repeatedly used to support each of the aims. ..
- POLYAMINE INVOLVEMENT IN MAMMARY CARCINOGENESISAndrea Manni; Fiscal Year: 2001....
- CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESISLinqi Zhang; Fiscal Year: 2003....
- Regulation of Nuclear Import/Export of 5-LipoxygenaseThomas Brock; Fiscal Year: 2006..This foundation can then be used to elucidate the ways these factors can change and give rise to the disease states that arise from abnormal 5-LO localization and LT synthesis. ..
- RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODELMichael Lawton; Fiscal Year: 2004..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..