tonsil

Summary

Summary: A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX situated on each side of the fauces, between the anterior and posterior pillars of the soft palate (PALATE, SOFT).

Top Publications

  1. ncbi The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
  2. pmc Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
    Respir Res 7:36. 2006
  3. ncbi Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 27:1463-70. 2003
  4. ncbi Regulation of the tonsil cytokine milieu favors HIV susceptibility
    Niki M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr, MSC 4352, Bethesda, MD 20892, USA
    J Leukoc Biol 80:1145-55. 2006
  5. ncbi NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    Barbara Morandi
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Eur J Immunol 36:2394-400. 2006
  6. ncbi Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report
    Margaret J Lesmeister
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, 1 Hospital Drive, M616 Medical Sciences Building, Columbia, MO 65212, USA
    Int J Pediatr Otorhinolaryngol 70:987-92. 2006
  7. ncbi CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides
    Florian Gantner
    Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Diseases Research, Japan
    Eur J Immunol 33:1576-85. 2003
  8. pmc Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers
    Chia Chi Ku
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Virol 76:11425-33. 2002
  9. pmc Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
    J Clin Invest 114:1640-9. 2004
  10. ncbi Classical swine fever virus induces activation of plasmacytoid and conventional dendritic cells in tonsil, blood, and spleen of infected pigs
    Agnès Jamin
    French Agency for Food Safety AFSSA, Poultry and Swine Research Laboratory, Swine Virology Immunology Unit, BP 53, 22440 Ploufragan, France
    Vet Res 39:7. 2008

Detail Information

Publications263 found, 100 shown here

  1. ncbi The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
    ..These results also suggest secondary lymphoid organs as a possible site of NK cell differentiation and self-tolerance acquisition...
  2. pmc Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, 205 02 Malmo, Sweden
    Respir Res 7:36. 2006
    ..In the present study, the expression profile of TLR1-TLR10 was characterized in human tonsil T cells, focusing on differences between subsets of CD4+ T helper (Th) cells and CD8+ cytotoxic T lymphocytes (CTL)..
  3. ncbi Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 27:1463-70. 2003
    ..The HPV-positive carcinomas have a distinct histopathologic and immunophenotypic features...
  4. ncbi Regulation of the tonsil cytokine milieu favors HIV susceptibility
    Niki M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Dr, MSC 4352, Bethesda, MD 20892, USA
    J Leukoc Biol 80:1145-55. 2006
    ..To dissect the mechanisms underlying susceptibility to HIV in this compartment, isolated tonsil cells were studied for phenotypic and functional characteristics, which may account for their permissiveness to ..
  5. ncbi NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    Barbara Morandi
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Eur J Immunol 36:2394-400. 2006
    ..Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells via cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors...
  6. ncbi Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report
    Margaret J Lesmeister
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, 1 Hospital Drive, M616 Medical Sciences Building, Columbia, MO 65212, USA
    Int J Pediatr Otorhinolaryngol 70:987-92. 2006
    The Waldeyer's ring, comprised of the nasopharyngeal tonsil (adenoid), the paired tubal tonsils, the paired palantine tonsils, and the lingual tonsil, is arranged in a circular orientation around the wall of the throat...
  7. ncbi CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides
    Florian Gantner
    Bayer Yakuhin, Ltd, Research Center Kyoto, Respiratory Diseases Research, Japan
    Eur J Immunol 33:1576-85. 2003
    ..We investigated the expression of the CpG receptor, Toll-like receptor 9 (TLR9), in human tonsil B cells, and determined functional responses following stimulation by a well-characterized stimulatory CpG-..
  8. pmc Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers
    Chia Chi Ku
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    J Virol 76:11425-33. 2002
    ..The susceptibility of tonsil T cells to VZV suggests that these cells may be important targets during the initial VZV infection of upper ..
  9. pmc Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses
    Hyung W Lim
    Laboratory of Immunology and Hematopoiesis, Department of Pathobiology, Purdue University, West Lafayette, Indiana 47907, USA
    J Clin Invest 114:1640-9. 2004
    ..Our results have identified a subset of Tregs that is physiologically relevant to GC-Th cell-dependent B cell responses and a potential regulation mechanism for the trafficking of these Tregs to GCs...
  10. ncbi Classical swine fever virus induces activation of plasmacytoid and conventional dendritic cells in tonsil, blood, and spleen of infected pigs
    Agnès Jamin
    French Agency for Food Safety AFSSA, Poultry and Swine Research Laboratory, Swine Virology Immunology Unit, BP 53, 22440 Ploufragan, France
    Vet Res 39:7. 2008
    ..Detection of antigen activated B lymphocytes in tonsil T-cell areas at 72 h pi, subsequently to the transient translocation of the viral E2 protein within germinal ..
  11. ncbi The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression
    Francisco Medina
    Servicio de Inmunologia, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009 Cadiz, Spain
    Blood 99:2154-61. 2002
    ..In addition, by using the common CD38(h) feature, human PCs from tonsil (as a possible source of early PCs), from blood from tet-immunized donors (as the putative precursors of BM PCs), ..
  12. pmc Transcriptional analysis of the B cell germinal center reaction
    Ulf Klein
    Institute for Cancer Genetics and Department of Pathology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:2639-44. 2003
    ..These results provide insights into the dynamics of the GC reaction and represent the basis for the analysis of B cell malignancies...
  13. pmc Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance
    Andrew D Hislop
    Institute for Cancer Studies and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Clin Invest 115:2546-55. 2005
    ..We therefore studied how responses localize to the tonsil, a major target site for EBV, during primary infection and persistence...
  14. ncbi Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease
    T R Spraker
    Department of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA
    J Vet Diagn Invest 14:3-7. 2002
    ..The MAb F99/97.6.1 immunohistochemistry assay was evaluated in brain and tonsil tissue from 100 mule deer that had spongiform encephalopathy compatible with CWD and from 1,050 mule deer outside ..
  15. ncbi Productive HIV infection of resting CD4+ T cells: role of lymphoid tissue microenvironment and effect of immunomodulating agents
    Audrey Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, MSC 1576, Building 10, Room 6A33, 10 Center Drive, Bethesda, MD 20892 1576, USA
    AIDS Res Hum Retroviruses 19:847-56. 2003
    ..The ability of resting CD4+ T cells to support HIV replication in the microenvironment of the lymphoid tissue has implications in the pathogenesis of HIV disease and may provide an additional avenue for therapeutic intervention...
  16. pmc Tonsil epithelial factors may influence oropharyngeal human immunodeficiency virus transmission
    Niki M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda 20892, USA
    Am J Pathol 171:571-9. 2007
    b>Tonsil epithelium has been implicated in human immunodeficiency virus (HIV) pathogenesis, but its role in oral transmission remains controversial...
  17. ncbi Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking
    Diana Palmeri
    Department of Anatomy and Program of Immunology, University of California, San Francisco, USA
    J Leukoc Biol 75:910-27. 2004
    ..novel HEC-specific proteins with potential function in the recruitment cascade, we sequenced a normalized human tonsil HEC cDNA library (generated from an inflamed tonsil) from which lymphocyte and human umbilical vein endothelial ..
  18. pmc Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo
    Lauri L Laichalk
    Dept of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Ave, Boston, MA 02111, USA
    J Virol 79:1296-307. 2005
    ....
  19. ncbi Development of the palatine tonsil in conventional and germ-free piglets
    Stephen Wilson
    Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU, UK
    Dev Comp Immunol 29:977-87. 2005
    ..The results suggest that the microbial environment influences the development of the tonsil immunological architecture...
  20. ncbi Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad, Catolica de Chile, Chile
    Microvasc Res 68:247-57. 2004
    The regulation of gap junctional communication by histamine was studied in primary cultures of human tonsil high endothelial cells (HUTECs)...
  21. ncbi The correlation among obesity, apnea-hypopnea index, and tonsil size in children
    Yuen Yu Lam
    Department of Paediatrics, Kwong Wah Hospital, 25 Waterloo Road, Hong Kong SAR
    Chest 130:1751-6. 2006
    ..We hypothesized that there is a significant correlation between the degree of obesity and the severity of OSA in children...
  22. ncbi Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4
    Elizabeth J Ryan
    Regional Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195, USA
    J Immunol 169:5638-48. 2002
    ..Therefore, the function of DCAL-1 on DCs and B cells may act as a T cell costimulatory molecule, which skews CD4(+) T cells toward a Th2 response by enhancing their secretion of IL-4...
  23. ncbi Higher maturity and connective tissue association distinguish resident from recently generated human tonsil plasma cells
    Francisco Medina
    Servicio de Inmunología and Unidad de Investigación, Hospital Universitario Puerta del Mar, Cadiz, Spain
    J Leukoc Biol 82:1430-6. 2007
    Human plasma cells (PC) are present in cell suspensions obtained from the tonsil by mechanical disaggregation (PC(MECH))...
  24. ncbi Human beta-defensins and toll-like receptors in the upper airway
    S Claeys
    Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 58:748-53. 2003
    ..In this study, the expression of human beta-defensins (HBD) 2 and 3 and toll-like receptors (TLR) 2 and 4 in various upper airway diseases was investigated...
  25. ncbi Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Int Immunol 14:883-92. 2002
    ..MCP-2/CCL8, MCP-3/CCL7, eotaxin/CCL11 and macrophage-derived chemokine (MDC)/CCL22 on the locomotion of human tonsil B lymphocytes and their subsets...
  26. ncbi Comparison of histology between recurrent tonsillitis and tonsillar hypertrophy
    P C Zhang
    Department of Otolaryngology, The National University of Singapore, Singapore
    Clin Otolaryngol Allied Sci 28:235-9. 2003
    ..It may also explain the difference in aetiology and/or immune defence mechanism underlying these two conditions...
  27. ncbi Rabbit tonsil-associated M-cells express cytokeratin 20 and take up particulate antigen
    Alessandro Carapelli
    Dept of Pharmacology Giorgio Segre, Section of Morphology, Via Aldo Moro 4, University of Siena, Siena, Italy
    J Histochem Cytochem 52:1323-32. 2004
    ..was identified at 46 kD on samples of proteins from the intermediate filament-enriched cytoskeletal fraction of tonsil epithelium...
  28. ncbi Bacteriologic comparison of tonsil core in recurrent tonsillitis and tonsillar hypertrophy
    Jin Hyeok Jeong
    Department of Otolaryngology, College of Medicine, Hanyang University, Seoul, Korea
    Laryngoscope 117:2146-51. 2007
    ..The purpose of this study was to analyze the underlying bacterial pathogens in tonsillar disease...
  29. pmc Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells
    Jacob M van Laar
    B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Pathol 171:917-27. 2007
    ..Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion...
  30. pmc Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University Hospital of Pisa, Pisa, Italy
    Antimicrob Agents Chemother 46:1594-6. 2002
    ..Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose...
  31. ncbi A case of unexpected difficult airway due to lingual tonsil hypertrophy
    H Asbjørnsen
    Department of Anaesthesia and Intensive Care Medicine, Haukeland University Hospital, Bergen, Norway
    Acta Anaesthesiol Scand 52:310-2. 2008
    Clinical value of preoperative bedside screening tests for predicting difficult airway remains limited. Asymptomatic lingual tonsil hypertrophy is a known cause of unexpected difficult airway. We report a case as a reminder of this.
  32. ncbi Complete upper airway obstruction after induction of anesthesia in a child with undiagnosed lingual tonsil hypertrophy
    Mauro Arrica
    Department of Anesthesia, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Paediatr Anaesth 16:584-7. 2006
    We present a case of a 9-year-old patient with previously undiagnosed lingual tonsil hypertrophy (LTH) that caused sudden and complete airway obstruction and inability to ventilate on induction of anesthesia...
  33. pmc Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo
    Salim Bounou
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Hôpital CHUL, Ste Foy, Quebec G1V 4G2, Canada
    J Virol 76:1004-14. 2002
    ....
  34. ncbi Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development
    Fenghuang Zhan
    Donna and Donald Lambert Laboratory of Myeloma Genetics at the Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Blood 101:1128-40. 2003
    ..0005) identified 359 and 500 previously defined and novel genes that distinguish tonsil BCs from tonsil PCs (early differentiation genes [EDGs]), and tonsil PCs from bone marrow PCs (late ..
  35. ncbi CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
    Maire F Quigley
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Immunol 37:3352-62. 2007
    ..CXCR5+ CD8 T cells were found in tonsil B cell follicles, and isolated cells migrated towards CXCL13 in vitro...
  36. ncbi Detection of Helicobacter pylori and its CagA gene in tonsil and adenoid tissues by PCR
    Meltem Yalinay Cirak
    School of Medicine, Department of Microbiology and Clinical Microbiology, Gazi University, Ankara, Turkey
    Arch Otolaryngol Head Neck Surg 129:1225-9. 2003
    ..To determine the presence of Helicobacter pylori and, if detected, the prevalence of the CagA gene in adenotonsillectomy specimens by polymerase chain reaction (PCR)...
  37. ncbi Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population
    Tonia Woodberry
    Partners AIDS Research Center, Massachusetts General Hospital, Boston 02129, USA
    J Immunol 175:4355-62. 2005
    ..EBV-specific, tonsil-resident, but not PBMC-derived, T cells expressed the integrin/activation marker CD103 (alphaEbeta7), consistent ..
  38. ncbi Ex vivo modeling of oral HIV transmission in human palatine tonsil
    Diane M Maher
    Department of Microbiology, MMC 196, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Histochem Cytochem 53:631-42. 2005
    ..By using human palatine tonsil from routine tonsillectomies and semen from HIV-positive donors, we have created an experimental equivalent to ..
  39. ncbi Interactions between Streptococcus suis serotype 2 and cells of the myeloid lineage in the palatine tonsil of the pig
    Stephen M Wilson
    School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU, United Kingdom
    Vet Immunol Immunopathol 117:116-23. 2007
    ..The palatine tonsil is one of the main sites where the organism can be recovered, both in infected and carrier animals...
  40. pmc The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium
    Andrew C Hoover
    Department of Otolaryngology Head and Neck Surgery, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Arch Otolaryngol Head Neck Surg 133:495-502. 2007
    ..To provide a manipulatable system to study the mechanism of human papillomavirus 16 (HPV16) E6-related transformation of an epithelial cell type affected by HPV16 in humans...
  41. ncbi HIV-1 does not provoke alteration of cytokine gene expression in lymphoid tissue after acute infection ex vivo
    Annette Audigé
    Division of Infectious Diseases and Hospital Epidemiology, Institute of Clinical Immunology, and Clinic of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    J Immunol 172:2687-96. 2004
    ..These results also indicate that different molecular mechanisms govern HIV replication in tissue blocks and HLAC. Prevention of effective cytokine responses may be an important mechanism that HIV uses during acute infection...
  42. ncbi Transmission of chronic wasting disease of mule deer to Suffolk sheep following intracerebral inoculation
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Center, U S Department of Agriculture, Ames, IA 50010, USA
    J Vet Diagn Invest 18:558-65. 2006
    ..These findings demonstrate that transmission of the CWDmd agent to sheep via the intracerebral route is possible. Interestingly, the host genotype may play a notable part in successful transmission and incubation period of CWDmd...
  43. pmc Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells
    William C Spanos
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
    Head Neck 30:139-47. 2008
    ..Human papillomavirus 16 (HPV16) has been associated with head and neck squamous cell carcinoma (HNSCC) in up to 60% of sampled specimens...
  44. ncbi Pathogenesis of experimental bovine spongiform encephalopathy: preclinical infectivity in tonsil and observations on the distribution of lingual tonsil in slaughtered cattle
    G A H Wells
    Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey
    Vet Rec 156:401-7. 2005
    ..at stages of pathogenesis previously indicated by mouse bioassay, traces of infectivity were found in the palatine tonsil of cattle killed 10 months after exposure...
  45. ncbi Germinal centers regulate human Th2 development
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 171:1657-66. 2003
    In the present study we demonstrate that all CD4(+) T cells in human tonsil expressing the Th2-selective receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) also 1) express high levels of CXCR5, and 2) ..
  46. ncbi Solitary fibrous tumor with atypical histological features occurring in the palatine tonsil: an uncommon neoplasm in an uncommon site
    Ricardo Silvestre Macarenco
    Department of Pathology, Faculdade de Medicina de Botucatu, State University of Sao Paulo, Botucatu SP, Brazil
    J Oral Pathol Med 35:602-5. 2006
    ..We report the first case of a SFT arising from the palatine tonsil of a 62-year-old man...
  47. ncbi Distribution and phenotype of Epstein-Barr virus-infected cells in human pharyngeal tonsils
    S David Hudnall
    Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
    Mod Pathol 18:519-27. 2005
    ..non-B cells, the immunophenotype of all EBV-infected cells in reactive human tonsils was determined by subjecting tonsil sections to dual/triple EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (..
  48. ncbi Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin
    Emily L Abbot
    Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Cell Microbiol 9:1822-33. 2007
    ..pyogenes strain SF370 to both human tonsil epithelium and primary human keratinocytes, which represent the two main sites of infection by this human-specific ..
  49. ncbi Obese obstructive sleep apnea patients with tonsil hypertrophy submitted to tonsillectomy
    F L Martinho
    Departamento de Otorrinolaringologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 39:1137-42. 2006
    ..e., obese OSAHS patients with tonsil hypertrophy...
  50. ncbi Tonsil size and body mass index are important factors for efficacy of simple tonsillectomy in obstructive sleep apnoea syndrome
    S Nakata
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Otolaryngol 31:41-5. 2006
    ..To evaluate the efficacy of simple tonsillectomy to treat obstructive sleep apnoea syndrome (OSAS) in adults...
  51. ncbi [Report of a case: large tonsillolith in palatine tonsil]
    F J Cogolludo Pérez
    Servicio de ORL, Hospital Clinico San Carlos, Madrid
    Acta Otorrinolaringol Esp 53:207-10. 2002
    A 69-year-old woman presented with a one-year history of dysphagia and a hard overgrowth of the right palatine tonsil visible in oral examination...
  52. ncbi Extramedullary plasmacytoma of the tonsil diagnosed by fine-needle aspiration cytology
    Yu Sakai
    Department of Pathology, Japan Self Defense Forces Sapporo General Hospital, Hokkaido 062 8610, Japan
    Ann Diagn Pathol 12:41-3. 2008
    ..Examination of the oral cavity showed enlargement of the left tonsil. Magnetic resonance imaging demonstrated a solid mass, measuring 3.2 x 2.0 x 3.8 cm, in the left tonsil...
  53. pmc Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers
    Dirk M Pegtel
    Department of Pathology, Tufts University School of Medicine, Jaharis Bldg, 150 Harrison Avenue, Boston, MA 02111, USA
    J Virol 78:12613-24. 2004
    ..In this report, we show the establishment and characterization of an ex vivo culture model of tonsil epithelial cells, a likely site for EBV infection in vivo...
  54. ncbi Determination of in vivo protein synthesis in human palatine tonsil
    Anna Januszkiewicz
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
    Clin Sci (Lond) 108:179-84. 2005
    ..The aim of the present study was to investigate if the immunological activation of the human palatine tonsil is reflected by a high metabolic activity, as determined by in vivo measurement of protein synthesis...
  55. ncbi Detection of the archetypal regulatory region of JC virus from the tonsil tissue of patients with tonsillitis and tonsilar hypertrophy
    Atsushi Kato
    Department of Urology, Mitsui Memorial Hospital, Tokyo, Japan
    J Neurovirol 10:244-9. 2004
    ..Nevertheless, Monaco et al (J Virol 70: 7004-7012, 1996) reported that PML-type regulatory regions occur in human tonsil tissue. The purpose of this study is to confirm their findings...
  56. ncbi Quantitative cytokine gene expression in human tonsils at excision and during histoculture assessed by standardized and calibrated real-time PCR and novel data processing
    Athos Bonanomi
    Division of Infectious Diseases, University Children s Hospital of Zurich, Zurich, Switzerland
    J Immunol Methods 283:27-43. 2003
    ..b>Tonsil histocultures could serve as a valuable ex vivo model system for further, donor-dependent, studies on activation ..
  57. ncbi Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2
    Shao Heng He
    Allergy and Inflammation Research Institute, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 26:568-74. 2005
    ..To investigate the effects of the agonists of proteinase activated receptor (PAR)-2, and histamine on degranulation of human mast cells...
  58. ncbi Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting disease
    Katherine I O'Rourke
    Agricultural Research Service, U S Department of Agriculture, Animal Disease Research Unit, Pullman, WA 99164, USA
    J Vet Diagn Invest 15:320-3. 2003
    A monoclonal antibody dot-blot assay was used to evaluate detergent lysates of tonsil tissue from mule deer to detect PrP(CWD), the marker for the cervid transmissible spongiform encephalopathy chronic wasting disease (CWD)...
  59. ncbi The dispersal of mucosal memory B cells: evidence from persistent EBV infection
    Lauri L Laichalk
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Immunity 16:745-54. 2002
    ..This pathway may reflect that of normal memory B cells derived from nasopharyngeal and other mucosal lymph nodes...
  60. ncbi Rapid PrP(Sc) detection in lymphoid tissue and application to scrapie surveillance of fallen stock in Japan: variable PrP(Sc) accumulation in palatal tonsil in natural scrapie
    Kimi Shimada
    Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Microbiol Immunol 49:801-4. 2005
    ..In this program, brain and palatal tonsil were examined by WB and three cases of sheep scrapie were detected...
  61. pmc HIV-gp160 modulates differentially the production in vitro of IgG, IgA and cytokines by blood and tonsil B lymphocytes from HIV-negative individuals
    F Cognasse
    GIMAP EA3064, Universite de Saint Etienne, Faculte de Medecine, Saint Etienne, France
    Clin Exp Immunol 132:304-8. 2003
    ..Gp160 induced significantly less total IgG by blood - but not tonsil-originating - B cells and did not affect total IgA production...
  62. ncbi A model system of oral HIV exposure, using human palatine tonsil, reveals extensive binding of HIV infectivity, with limited progression to primary infection
    Diane Maher
    Department of Microbiology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Infect Dis 190:1989-97. 2004
    ..We developed a mucosal model, using human palatine tonsil with intact external epithelium, to study events after oral exposure to HIV...
  63. ncbi Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections
    Kunihiko Maeda
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    J Histochem Cytochem 50:1475-86. 2002
    ..Our results are easily adaptable for routine practice and provided useful suggestions concerning the immunopathological behavior and diversity of the particular cells...
  64. ncbi Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue
    G R Kolar
    Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104a, USA
    Scand J Immunol 64:314-24. 2006
    ..representation of naïve and germinal centre B-cell subpopulations changed relative to total B lymphocytes in the tonsil. While the percentage of naïve and germinal centre B-cell subpopulations changes during the second half of life, ..
  65. pmc Biofilm formation by Haemophilus influenzae isolated from adeno-tonsil tissue samples, and its role in recurrent adenotonsillitis
    J Galli
    Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy
    Acta Otorhinolaryngol Ital 27:134-8. 2007
    ..with a morphology consistent with bacterial coccoid biofilms, were observed in all adenoid (15/15) and in 6/10 tonsil samples...
  66. pmc Streptococcal modulation of cellular invasion via TGF-beta1 signaling
    Beinan Wang
    Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Memorial Building, MMC 196, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:2380-5. 2006
    ..of TGF-beta1 to up-regulate integrin expression and intracellular invasion by GAS was reproduced in primary human tonsil fibroblasts, which could be a source of TGF-beta1 in chronically infected tonsils...
  67. ncbi Heterogeneity of freshly isolated human tonsil dendritic cells demonstrated by intracellular markers, phagocytosis, and membrane dye transfer
    Gianna Stent
    Department of Microbiology and Immunology, University of Melbourne, Grattan Street, Parkville, Australia
    Cytometry 48:167-76. 2002
    ..Heterogeneity within human dendritic cells (DCs) has been described but its functional relationships to cells of macrophage lineage and its role in human immunodeficiency virus (HIV) infection in vivo remain unclear...
  68. ncbi The unexpected difficult airway and lingual tonsil hyperplasia: a case series and a review of the literature
    Andranik Ovassapian
    Department of Anesthesia and Critical Care, The University of Chicago Hospitals, University of Chicago, Illinois 60637, USA
    Anesthesiology 97:124-32. 2002
    ..Lingual tonsil hyperplasia (LTH) is one risk factor for an unanticipated failed intubation that is not detectable during a ..
  69. ncbi [Extramedullary plasmocytoma of the left tonsil. A rare cause of tonsillar asymmetry]
    T Zehlicke
    Abteilung für Hals Nasen Ohrenheilkunde des Bundeswehrkrankenhauses Hamburg
    HNO 50:240-3. 2002
    ..First of all, squamous-cell carcinoma has to be taken into account, more rarely with malignant lymphoma. Tonsillektomie added by immunhistological examination of the preparation brings diagnostic certainty...
  70. ncbi [A preliminary study on the immune suppressive protein of stress in human tonsil]
    Jie Zhang
    Department of Physiology, The Health Science Center of Peking University, Beijing 100083
    Sheng Li Xue Bao 54:171-4. 2002
    ..In the present work, a protein similar to ISPS was found in human tonsil (a peripheral lymph tissue). Human tonsil was homogenized and the extract was prepared...
  71. ncbi Expression of chemokine receptors in normal and inflamed human intestine, tonsil, and liver--an immunohistochemical analysis with new monoclonal antibodies from the 8th international workshop and conference on human leucocyte differentiation antigens
    Frank Autschbach
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cell Immunol 236:110-4. 2005
    ..by the cytokine/chemokine receptor section of the 8th HLDA workshop on cryostat sections of normal human gut, tonsil, and liver...
  72. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    ..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
  73. ncbi Germinal center B cells constitute a predominant physiological source of IL-4: implication for Th2 development in vivo
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 168:3165-72. 2002
    ..In this report, we describe the anatomical localization as well as the identity of IL-4-producing cells in human tonsil, a representative secondary lymphoid organ...
  74. ncbi The human marginal zone B cell
    Mariella Dono
    Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Ann N Y Acad Sci 987:117-24. 2003
    ..If the current distinction into B1 and B2 cells has to be maintained also for humans, it is likely that only these CD5-positive cells rather than the FM B cells should be called B1 cells...
  75. ncbi Simultaneous, clonally identical T cell expansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitis
    Mitsuhiro Kawano
    Kanazawa Social Insurance Hospital, Kanazawa, Japan
    Arthritis Rheum 48:2483-8. 2003
    ..Analysis of infiltrating T cell clones in tonsil and synovium using T cell receptor V(beta) repertoire and third complementarity-determining region size ..
  76. ncbi Temperature-controlled radiofrequency tonsil reduction in children
    Lionel M Nelson
    Arch Otolaryngol Head Neck Surg 129:533-7. 2003
    To evaluate the safety and efficacy of temperature-controlled radiofrequency tonsil reduction in the treatment of children with a sleep-related breathing disorder associated with tonsillar obstructive hypertrophy.
  77. ncbi Long-term effects of pediatric adenotonsillectomy on serum immunoglobulin levels: results of a randomized controlled trial
    Emma H van den Akker
    Department of Otorhinolaryngology, Wilhelmina Children s Hospital University Medical Center Utrecht, The Netherlands
    Ann Allergy Asthma Immunol 97:251-6. 2006
    ....
  78. ncbi The effects of tonsillectomy and adenoidectomy on pulmonary arterial pressure in children
    Mustafa Deniz Yilmaz
    Department of Otolaryngology Head and Neck Surgery, Afyon Kocatepe University, Afyon, Turkey
    Am J Otolaryngol 26:18-21. 2005
    ....
  79. ncbi Effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy: open, randomised controlled trial
    Birgit K van Staaji
    Clin Otolaryngol 30:60-3. 2005
    ..To assess the effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy...
  80. ncbi [Snoring in children]
    M Francois
    Service ORL, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, 48, boulevard Serurier, 75935 Paris Cedex 19, France
    Arch Pediatr 13:207-10. 2006
    ..Snoring is severe when associated with sleep apneas. The 3 most frequent causes of snoring in children are enlarged adenoids, enlarged tonsils and blocked nose due to allergic rhinitis...
  81. ncbi Children with obstructive sleep-disordered breathing generate high-frequency inspiratory sounds during sleep
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Sleep 27:1154-61. 2004
    ..Our objective was to determine whether HFIS occur in most children with obstructive SDB and adenotonsillar hypertrophy and whether adenotonsillectomy reduces HFIS...
  82. ncbi Optimal site for throat culture: tonsillar surface versus posterior pharyngeal wall
    E L van der Veen
    Department of Otorhinolaryngology E 04 140 5, Wilhelmina Children s Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands
    Eur Arch Otorhinolaryngol 263:750-3. 2006
    ..When detection of other bacteria is also important, such as for research purposes, the posterior pharyngeal wall should be sampled as well...
  83. ncbi Changes in behavior and attentional capacity after adenotonsillectomy
    Barbara C Galland
    Department of Women s and Children s Health, University of Otago, Dunedin, New Zealand
    Pediatr Res 59:711-6. 2006
    ....
  84. ncbi Temperature-controlled radiofrequency treatment of tonsillar hypertrophy for reduction of upper airway obstruction in pediatric patients
    James M Coticchia
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Arch Otolaryngol Head Neck Surg 132:425-30. 2006
    To determine if temperature-controlled radiofrequency (TCRF) tonsil reduction and adenoidectomy (TCRF&A) and conventional tonsillectomy and adenoidectomy (T&A) are statistically similar in outcome and to compare morbidity between ..
  85. ncbi Growth failure and sleep disordered breathing: a review of the literature
    Karen Bonuck
    Department of Epidemiology and Population Health, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467 2490, USA
    Int J Pediatr Otorhinolaryngol 70:769-78. 2006
    ....
  86. ncbi Improved somatic growth following adenoidectomy and tonsillectomy in young children. Possible pathogenetic mechanisms
    Harilaos S Vontetsianos
    ENT Department, First Paediatric Department, Athens University, Children s Hospital, Agia Sophia Athens, Greece
    Hormones (Athens) 4:49-54. 2005
    ..All other metabolic indices did not change. In conclusion, linear grow post-Adenotonsillectomy improved in children aged <5 years and was associated with improved with IGF-1/GH ratio, increased Hbeta values and decreased in WBC...
  87. ncbi The effects of chin lift and jaw thrust while in the lateral position on stridor score in anesthetized children with adenotonsillar hypertrophy
    Young Chang P Arai
    Department of Anesthesiology, Kochi Medical School, Oko cho, Nankoku, Kochi, 783 8505, Japan
    Anesth Analg 99:1638-41, table of contents. 2004
    ..We conclude that lateral positioning combined with airway maneuvers significantly improved airway patency compared with the airway maneuvers alone for patients in the supine position...
  88. pmc Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea
    Aviv D Goldbart
    Department of Pediatrics, Kosair Children s Hospital Research Institute, and Department of Surgery, Division of Ear Nose and Throat, University of Louisville, Louisville, Kentucky 40202, USA
    Pediatr Res 62:489-94. 2007
    ....
  89. ncbi Upper airway dynamic responses in children with the obstructive sleep apnea syndrome
    Carole L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287, USA
    Pediatr Res 57:99-107. 2005
    ..Further, we speculate that this compensatory response is lacking in children with OSAS, most likely due to either habituation to chronic respiratory abnormalities during sleep or to mechanical damage to the upper airway...
  90. ncbi Alteration of adenoid tissue alkaline and acid phosphatase in children with secretory otitis media
    Snezana Jesic
    Institute for Otorhinolaryngology and Maxillofacial surgery, Clinical Centre of Serbia, 11000 Belgrade, Pasterova 2 Street, Serbia and Montenegro
    Int J Pediatr Otorhinolaryngol 70:1069-76. 2006
    ..Specific activity and kinetic properties were studied in palatinal tonsils and adenoids of children with secretory otitis (OME) and compared with children with recurrent tonsillitis without ear involvement...
  91. ncbi Post-tonsillectomy morbidity and quality of life in pediatric patients with obstructive tonsils and adenoid: microdebrider vs electrocautery
    Craig S Derkay
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, 825 Fairfax Avenue, Ste 510, Norfolk, VA 23507 1914, USA
    Otolaryngol Head Neck Surg 134:114-20. 2006
    ..To prospectively compare outcomes in children over age 2 with obstructive adenotonsillar hypertrophy when tonsillectomy is performed utilizing an intracapsular microdebrider technique versus low-wattage electrocautery technique...
  92. ncbi Is diagnostic tonsillectomy indicated in all children with asymmetrically enlarged tonsils?
    Anton C van Lierop
    Division of Otorlaryngology, University of Cape Town, South Africa
    S Afr Med J 97:367-70. 2007
    ....
  93. ncbi Changes in growth pattern, body composition and biochemical markers of growth after adenotonsillectomy in prepubertal children
    Betul Ersoy
    Celal Bayar University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Manisa, Turkey
    Int J Pediatr Otorhinolaryngol 69:1175-81. 2005
    ..The aim of this study was to determine the changes in growth, body composition and biochemical markers associated with growth following adenotonsillectomy (A&T) in prepubertal children...
  94. ncbi Oxidants and antioxidants in tonsillar and adenoidal tissue in chronic adenotonsillitis and adenotonsillar hypertrophy in children
    A Faruk Kiroglu
    Yuzuncu Yil University, School of Medicine, Department of Otolaryngology, Van, Turkey
    Int J Pediatr Otorhinolaryngol 70:35-8. 2006
    ..The aim of the study is to determine the possible role of oxidants and antioxidants in the pathogenesis of chronic adenotonsillitis and adenotonsillar hypertrophy in children...
  95. ncbi Pathologic evaluation of routine tonsillectomy and adenoidectomy specimens in the pediatric population: is it really necessary?
    Taner K Erdag
    Dokuz Eylul University School of Medicine, Department of Otolaryngology, Izmir, Turkey
    Int J Pediatr Otorhinolaryngol 69:1321-5. 2005
    ..To evaluate the necessity of histopathologic examination for routine tonsillectomy and/or adenoidectomy in terms of unexpected malignancy by evaluating a large group of pediatric patients retrospectively with review of the literature...
  96. ncbi Tonsillitis index: an objective tool for quantifying the indications for tonsillectomy for recurrent acute tonsillitis
    Keiji Fujihara
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Int J Pediatr Otorhinolaryngol 69:1515-20. 2005
    ..TI may be a useful tool for surgical decision making...
  97. ncbi Cytokines locally produced by lymphocytes removed from the hypertrophic nasopharyngeal and palatine tonsils
    Anna Komorowska
    Department of Otolaryngology, Polish Mother s Memorial Hospital, Research Institute, Lodz, Poland
    Int J Pediatr Otorhinolaryngol 69:937-41. 2005
    Human palatine tonsils and the nasopharyngheal tonsil are the largest components of the Waldeyer's ring...
  98. ncbi The effect of adenotonsillectomy on oxygen saturation in children with sleep breathing disorders
    Jaime Arrarte
    Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Pos graduate Program, Brazil
    Int J Pediatr Otorhinolaryngol 71:973-8. 2007
    ..To evaluate the effect of adenotonsillectomy on the oxygen saturation measures by nocturnal pulse oximetry in children with sleep breathing disorders (SBD)...
  99. ncbi Tonsillar colonization is unlikely to play important role in Helicobacter pylori infection in children
    Boris Jelavic
    Department of Otorhinolaryngology, Mostar University Hospital, Mostar, Bosnia and Herzegovina
    Int J Pediatr Otorhinolaryngol 71:585-90. 2007
    ....
  100. ncbi Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy
    Riva Tauman
    Kosair Children s Hospital Research Institute and the Department of Pediatrics, Division of Pediatric Sleep Medicine, University of Louisville, Louisville, Kentucky, USA
    J Pediatr 149:803-8. 2006
    ..To investigate the relative contribution of various risk factors to the surgical outcome of adenotonsillectomy for obstructive sleep apnea syndrome in children...
  101. ncbi [Muramidase and lactoferrin in adenoidal hypertrophies, hypertrophic and chronic infected tonsil tissue--a quantitative analysis]
    M Schwaab
    Universitätsklinik für Hals Nasen Ohrenheilkunde und Kopf und Halschirurgie, Ruhr Universitat Bochum
    Laryngorhinootologie 84:660-4. 2005
    ..Till now there are only immunohistochemical and microbiological studies on the presence of muramidase and lactoferrin in adenoid and tonsil tissue available.

Research Grants62

  1. HOST IMMUNITY TO EBV INFECTION IN VITRO AND IN VIVO
    David A Thorley-Lawson; Fiscal Year: 2013
    ..To test this we will show that: 1. P. falciparum activates AID in vitro. Tonsil B cells will be cultured with various AID agonists combined with parasite preparations including whole extracts ..
  2. Varicella-Zoster Virus: T Cell/Skin Tropism &Immunity
    Ann Arvin; Fiscal Year: 2013
    ..VZV infects human tonsil T cells very efficiently and infected tonsil T cells transfer VZV into skin xenografts, where lesion formation ..
  3. Role of HSF1 in B cell activation and lymphoma
    Tharu M Fernando; Fiscal Year: 2013
    ..is induced in the GC response and DLBCL via HSF1 ChIP-seq and gene expression analysis (mRNA-seq) in normal human tonsil-derived na?ve and GC B cells and in malignant human DLBCL cell lines and primary DLBCL patient samples...
  4. Plasmacytoid Dendritic Cells in HIV Pathogenesis
    Patricia Fitzgerald-Bocarsly; Fiscal Year: 2013
    ..blood of HIV-infected patients;second, we will determine whether pDC:HIV-infected T cell fusion occurs in tonsil suspension cells and tonsil organ culture;third, in collaboration with Dr...
  5. Integrative epigenomic/genomic profiling and biomarker discovery in HPV+ and HPV-
    MAUREEN AGNES SARTOR; Fiscal Year: 2013
    ..Currently, treatment of head and neck SCC (HNSCC) is not based on HPV status. The incidence of tonsil and tongue cancers have been increasing annually and many contain high risk HPV...
  6. Virus-Host Cell Interactions in AIDS-Associated PML
    Walter Atwood; Fiscal Year: 2013
    ..First, the anatomical site of virus latency is not known but kidney, tonsil, bone marrow, and brain have all been postulated to be involved...
  7. HIV-Induced CD4 T-Cell Depletion: An Innate Host Defense Gone Awry?
    Warner C Greene; Fiscal Year: 2013
    ..Using primary human lymphoid aggregate cultures (HLAC) formed with tonsil or spleen tissue, we have explored how CD4 T cells die during HIV infection in lymphoid tissues...
  8. Augmenting Innate Immunity to Protect the Oral Mucosa
    Mark C Herzberg; Fiscal Year: 2013
    ..cytotoxic, proinflammatory immune, and carcinogenic side effects, we will concurrently model this system in human tonsil explants ex vivo...
  9. Determining Whether Transient HIV Infection Occurs
    Miles W Cloyd; Fiscal Year: 2010
    ..HIV was found by PCR in the tonsil of one such transiently HIV infected subject, but it was not detected in the PBMCs...
  10. THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITY
    Marco Colonna; Fiscal Year: 2013
    ..We recently discovered a novel subset of tonsil and gut innate immune cells that express natural killer (NK) cell markers, but, in contrast to conventional NK ..
  11. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2007
    ..real time PCR assay that detects adenoviral DNA in mononuclear cell preparations from the majority (81%) of tonsil and adenoid specimens tested...
  12. STRUCTURE AND GENETIC CONTROL OF IGA
    Katherine Knight; Fiscal Year: 2000
    ..assays, most of the 13 C/a genes are known to be expressed in gut-associated lymphoid tissue, but in lung and tonsil of the respiratory tract, only one C/a gene, C/a4 is expressed...
  13. Intercellular communication in Epstein Barr virus reactivation
    Erik K Flemington; Fiscal Year: 2013
    ..This model proposes that environmental cues from the oral/tonsil epithelium (in the late stages of the germinal center reaction, for example) trigger reactivation in B-cells, ..
  14. IMMUNOLOGICAL ASPECTS OF RETINOIDS IN HUMAN CANCER
    Neil Sidell; Fiscal Year: 1993
    ..the effects of RA along with various activation\growth signals on the differentiation and the secretion from fresh tonsil lymphocytes...
  15. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2005
    ..that the frequency of HHV-8 shedding in saliva is increased in the presence of HIV infection, with lingual and tonsil swabs demonstrating the highest viral titers. Salivary glands do not appear to be a significant source of HHV-8...
  16. Tonsil Model of Oral HIV-1 Infection via Breastfeeding
    Diane Shugars; Fiscal Year: 2003
    ..This exploratory study will develop and characterize a human tonsil histoculture model of oral HIV-1 acquisition through breast milk...
  17. EFFECTS OF TONSIL-ADENOID SURGERY ON THROAT INFECTION
    JACK PARADISE; Fiscal Year: 1990
    ..Enrollment of subjects through August 1986 and follow-up through August, 1989 appears necessary to achieve results sufficiently conclusive to be persuasive to clinicians and to influence well-established standards of practice...
  18. Oral HIV Pathogenesis and Shedding
    Robert Coombs; Fiscal Year: 2005
    ..06). HIV was not isolated from saliva, buccal or salivary mucosa. Biopsies of palatine and lingual tonsil (n=6) revealed vRNA and p24 antigen within lymphoid follicles, despite HAART-suppressed plasma VL...
  19. Ultrasound-Mediated Tissue Preservation
    Wei Sing Chu; Fiscal Year: 2003
    ..Using this technique, we have demonstrated in lung and tonsil tissues that 1) the time of preservation is reduced from 24-48 hours to < 1 hour, 2) tissue morphology remains ..
  20. DENDRITIC CELLS AND HIV-1 PATHOGENESIS
    Ralph Steinman; Fiscal Year: 1999
    ..have visualized production infection of dendritic cells, including syncytia derived from dendritic cells in the tonsil and adenoid mucosia of 13 of 13 specimens from HIV-1 infected individuals, most of them asymptomatic...
  21. ORAL TRANSMISSION OF SIV IN NEONATAL AND ADULT MACAQUES
    SHAWN O NEIL; Fiscal Year: 2004
    ..that transmission will occur at multiple sites within the alimentary tract, including the lymphoepithelium of the tonsil, the respiratory mucosa of the nasopharynx, and the columnar epithelium of the gastrointestinal tract...
  22. Oral-Pharyngeal HHV-8 Infection
    Jeffrey Vieira; Fiscal Year: 2004
    ..concentrations of HHV-8 in saliva are higher in individuals with concurrent HIV infection and that swabs from the tonsil and lingual surfaces appear to contain the highest titers of virus...
  23. Genomic and Proteomic Analysis of HPV-Associated SCCHN
    Saleem Khan; Fiscal Year: 2009
    ..Since the majority of HPV-associated SCCHN arise in the oropharynx (tonsil and base of tongue), we will specifically analyze tumors from this sub-site...
  24. 5-LIPOXYGENASE STRUCTURE/FUNCTION IN MUCOSAL EPITHELIUM
    Thomas Brock; Fiscal Year: 2001
    ..The specific aims of this project are 1) to isolate and characterize the gene for the tonsil 5-LO enzyme, as well as its regulatory region, 2) to determine the properties of this novel 5-LO, with emphasis on ..
  25. CATALYTIC ANTIBODIES FOR HIV1 IMMUNOTHERAPY
    Sudhir Paul; Fiscal Year: 1999
    ..mechanism of neutralization and to approximate in vivo HIV-1 infection, including assay of neutralization using tonsil histoculture and SCID mouse models...
  26. Determining Whether Transient HIV Infection Occurs
    Miles Cloyd; Fiscal Year: 2004
    ..HIV was found by PCR in the tonsil of one such transiently HIV infected subject, but it was not detected in the PBMCs...
  27. HIV-1 Clones with Attenuated Cytopathic Effects
    David Camerini; Fiscal Year: 2004
    ..Characterize the replication and cytopathic effects, of R5 HIV-1 isolates from LTNP-HVL in FTOC, tonsil histoculture and SCID-hu mice...
  28. VALIDATION OF A DISEASE SPECIFIC HEALTH STATUS INSTRUMEN
    Michael Stewart; Fiscal Year: 1999
    ..No studies have evaluated the impact of tonsil and adenoid (T and A) disease on the health status or quality of life (QOL) of affected children...
  29. T CELL IMMUNITY AT ORAL VERSUS OTHER MUCOSAL SITES
    STEVEN LONDON; Fiscal Year: 2002
    ..We have demonstrated reovirus-specific immunity in the murine tonsil equivalent (Nasal Associated Lymphoid Tissue), salivary glands, and associated lymph nodes...
  30. Oral HIV Exposure May Result in Transient Infection
    Miles Cloyd; Fiscal Year: 2004
    ..HIV was found by PCR in the tonsil of one such transiently HIV infected subject, but it was not detected in the PBMCs...
  31. EPIDEMIOLOGY/MOLECULAR VIROLOGY OF ORAL HIV TRANSMISSION
    Timothy Schacker; Fiscal Year: 2002
    ..Animal data suggests of tonsil tissue can be easily infected with SIV and some observational studies suggest the rate of oral transmission may be ..
  32. MECHANISMS OF HEV CELL RECOGNITION OF APOPTOTIC CELLS
    Joan Cook Mills; Fiscal Year: 2000
    ..Primary cultures of human tonsil HEV cells will be used to determine whether HIV survives HEV cell phagocytosis of apoptotic HIV-infected ..
  33. CHIMERIC MRNA TEMPLATES DRIVE AIDS B CELL LYMPHOMAS
    Andrew Saxon; Fiscal Year: 1999
    ..SCID mice will be reconstituted with human tonsil B cells carrying u: c myc constructs that drive u: c myc rearrangement (Aim 1)...
  34. Does the HSV-1 latency associated transcript (LAT) encode a protein?
    Clinton Jones; Fiscal Year: 2008
    ..Studies will also determine whether LAT encoded proteins inhibit apoptosis, and whether these proteins are necessary for the latency reactivation cycle. [unreadable] [unreadable] [unreadable]..
  35. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  36. IL-15 Characterization Through Experimental Immunology
    Michael Caligiuri; Fiscal Year: 2009
    ..abstract_text> ..
  37. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    CAROLE MARCUS; Fiscal Year: 2008
    ..These studies will help elucidate the pathophysiology of OSAS in obese adolescents, ultimately resulting in improved management of this disease. ..
  38. GENES INVOLVED IN AIDS LYMPHOMAGENESIS
    Michael Teitell; Fiscal Year: 2002
    ..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..
  39. Cancer and Non-cancer Mortality in Meat Workers (1 RO1-OH 008687-01 A1 SOH)
    Eric Johnson; Fiscal Year: 2008
    ..Infectious disease is a NIOSH priority area. [unreadable] [unreadable] [unreadable]..
  40. THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMA
    Michael Caligiuri; Fiscal Year: 2002
    ..The limitations of the animal model preclude its use for studying the pathogenesis of AIDS PCNSL. ..
  41. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
    ..The confirmed demonstration of ALSV pro-viral DNA in the genome of exposed tumor samples but not in that of control tumor samples, will provide definitive evidence incriminating ALSV in human carcinogenesis. ..
  42. LIPOSOMAL S MUTANS DELIVERY SYSTEM FOR CARIES IMMUNITY
    Noel Childers; Fiscal Year: 2001
    ....
  43. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  44. Noninvasive Ventilation in Children with Cystic Fibrosis
    CAROLE MARCUS; Fiscal Year: 2004
    ..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
  45. MOLECULAR GENETICS OF A SYNDROME WITH HEARING IMPAIRMENT
    J Post; Fiscal Year: 2004
    ..The delineation of the panoply of genes involved in causing craniosynostosis will enhance our understanding of these diseases and suggest new therapeutic strategies. ..
  46. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
  47. Polyamines and Breast Cancer Biology
    Andrea Manni; Fiscal Year: 2005
    ..The ultimate goal of these studies is to identify critical signaling molecules which can be targeted in conjunction with antipolyamine therapy to optimize prevention of metastasis from breast cancer. ..
  48. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  49. Neurofeedback functional MRI
    Seung Schik Yoo; Fiscal Year: 2006
    ....
  50. Multimodal Imaging of the Sensory Gating Deficit in Chronic Cocaine Abusers
    ANDREW MAYER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. B cell functional and signaling abnormalities in SLE
    Jennifer Anolik; Fiscal Year: 2006
    ..abstract_text> ..
  52. Oral Exposure and Transmission of HIV
    Peter Southern; Fiscal Year: 2003
    ..Oral exposure to semen from HIV seropositive donors can lead to primary HIV infection. Tonsil organ culture systems have been developed in order to investigate the cellular and molecular mechanisms that ..
  53. Pneumococcal Biofilms in Otitis Media
    James Post; Fiscal Year: 2007
    ..Delineating the molecular basis of biofilms will not only advance our understanding of OM, but of chronic infectious disease in general. ..
  54. A Novel Model for the Study of Lung Pathogenesis of SARS
    Linqi Zhang; Fiscal Year: 2008
    ..These methods are repeatedly used to support each of the aims. ..
  55. POLYAMINE INVOLVEMENT IN MAMMARY CARCINOGENESIS
    Andrea Manni; Fiscal Year: 2001
    ....
  56. CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESIS
    Linqi Zhang; Fiscal Year: 2003
    ....
  57. Regulation of Nuclear Import/Export of 5-Lipoxygenase
    Thomas Brock; Fiscal Year: 2006
    ..This foundation can then be used to elucidate the ways these factors can change and give rise to the disease states that arise from abnormal 5-LO localization and LT synthesis. ..
  58. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..