spleen

Summary

Top Publications

  1. ncbi Structure and function of the spleen
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 5:606-16. 2005
  2. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
  3. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
  4. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
  5. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
  6. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
  7. doi A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 28:639-50. 2008
  8. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
  9. pmc Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
    Kanako L Lewis
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 35:780-91. 2011
  10. pmc Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    M Paula Longhi
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1589-602. 2009

Detail Information

Publications322 found, 100 shown here

  1. ncbi Structure and function of the spleen
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 5:606-16. 2005
    The spleen combines the innate and adaptive immune system in a uniquely organized way...
  2. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  3. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    ..Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation...
  4. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
    ..Importantly, rejection of highly immunogenic syngeneic tumors was impaired in Batf3-/- mice. These results suggest an important role for CD8alpha+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection...
  5. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion...
  6. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
    ..Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors...
  7. doi A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 28:639-50. 2008
    ..regulated by a unique CD1d(hi)CD5(+) B cell subset that was absent in Cd19(-/-) mice, represented only 1%-2% of spleen B220(+) cells in wild-type mice, but was expanded to approximately 10% of spleen B220(+) cells in hCD19Tg mice...
  8. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  9. pmc Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
    Kanako L Lewis
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 35:780-91. 2011
    ..We report that DC-specific deletion of the Notch2 receptor caused a reduction of DC populations in the spleen. Within the splenic CD11b(+) DC subset, Notch signaling blockade ablated a distinct population marked by high ..
  10. pmc Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    M Paula Longhi
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1589-602. 2009
    ..Therefore, the adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity...
  11. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  12. pmc Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis
    Susanne Nylen
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:805-17. 2007
    Visceral leishmaniasis (VL) is a life-threatening disease characterized by uncontrolled parasitization of the spleen, liver, and bone marrow...
  13. doi Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
    Zhuzhen Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Blood 118:1912-22. 2011
    ..These studies demonstrate that Fpn1 plays important roles in macrophage iron release in vivo and in modulating innate immune responses...
  14. pmc Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen
    Laura McCulloch
    The Roslin Institute and Royal Dick School of Veterinary Sciences, University of Edinburgh, Midlothian, United Kingdom
    PLoS Pathog 7:e1002402. 2011
    ..We show that PrP(C)-expression only on FDC is sufficient to sustain prion replication in the spleen. Furthermore, prion replication is blocked in the spleen when PrP(C)-expression is specifically ablated only on ..
  15. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    ....
  16. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..cloning of a recently identified IFN-gamma-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells...
  17. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    ..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
  18. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  19. ncbi Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
    ..Leukocyte cellularity was reduced in the bone marrow, peripheral blood, lymph nodes (LN), and spleen. Thymic cellularity, blood hematocrit, and platelet numbers were not affected...
  20. pmc Characterization of chicken spleen transcriptome after infection with Salmonella enterica serovar Enteritidis
    Marta Matulova
    Veterinary Research Institute, Brno, Czech Republic
    PLoS ONE 7:e48101. 2012
    ..Expression of AVD, EXFABP, IRG1, AH221, TRAP6, SAA and all immunoglobulin genes can be therefore used for the characterization of the course of S. Enteritidis infection in chickens...
  21. doi Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation
    Sarah Millot
    INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Universite Paris Diderot, Paris, France
    Blood 116:6072-81. 2010
    ..whereas after acute anemia, bone morphogenetic protein 4 (BMP4)-dependent stress erythropoiesis develops in the spleen. The aim of this work was to compare spleen stress erythropoiesis and bone marrow erythropoiesis in a mouse model ..
  22. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
  23. ncbi A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
    H Suzuki
    Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
    Nature 386:292-6. 1997
    ..In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens...
  24. doi Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
    Suresh K Balasubramanian
    Division of Environmental Science and Engineering, Department of Anatomy, National University of Singapore, Singapore
    Biomaterials 31:2034-42. 2010
    ..v.) injection in rats. Au was rapidly and consistently accumulated in liver (49.4+/-50.4-72.2+/-40.5 ng/g) and spleen (8.4+/-5.0-9.5+/-6.4 ng/g) throughout the entire timeframe of the study (2 months)...
  25. ncbi Balancing immunity and pathology in visceral leishmaniasis
    Amanda C Stanley
    Immunology and Infection Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Immunol Cell Biol 85:138-47. 2007
    ..donovani results in the development of organ-specific immunity in the two main target tissues of infection, the spleen and the liver...
  26. pmc CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6923-33. 2008
    ..In this study we compare two major DC subsets from mouse spleen. We find that CD8(+) DEC-205/CD205(+) DCs, but not the major fraction of CD8(-) DC inhibitory receptor-2 (DCIR2)(+)..
  27. doi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow to the spleen. In the absence of this receptor mice harbor higher parasitemias...
  28. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  29. ncbi Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes
    Shalin H Naik
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Parkville, Victoria 3050, Australia
    Nat Immunol 7:663-71. 2006
    ..Thus, the inflammatory status of the host influences the developmental origin and type of DC present in lymphoid tissues...
  30. ncbi Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination
    Henrik Lambert
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Cell Microbiol 8:1611-23. 2006
    ..DC in vivo, similar or higher numbers of Toxoplasma-infected DC reached the mesenteric lymph nodes and spleen respectively...
  31. pmc B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
    Irene Puga
    Institut Municipal d Investigació Mèdica Hospital del Mar, Barcelona, Spain
    Nat Immunol 13:170-80. 2011
    ..Here we identified neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell-independent immunoglobulin responses to circulating antigen...
  32. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum...
  33. ncbi Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 174:6477-89. 2005
    ..Thus, NOD-scid IL2Rgamma(null) mice engrafted with human mobilized blood stem cells provide a new in vivo long-lived model of robust multilineage human HSC engraftment...
  34. ncbi Regulation of plasma-cell development
    Miriam Shapiro-Shelef
    Departments of Microbiology, and Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nat Rev Immunol 5:230-42. 2005
    ....
  35. ncbi Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    A L Shaffer
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:51-62. 2002
    ....
  36. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..Stimulation of CD8-expressing T cells by dendritic cells from Peyer's patches, peripheral lymph nodes and spleen induced equivalent activation markers and effector activity in T cells, but only Peyer's patch dendritic cells ..
  37. ncbi STAT1-dependent innate immunity to a Norwalk-like virus
    Stephanie M Karst
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 299:1575-8. 2003
    ..The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease...
  38. pmc Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    S J Szabo
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:817-24. 1997
    ..Thus, IFN-gamma may prevent early Th cells from premature commitment to the Th2 pathway. Controlling the expression of the IL-12R beta 2 subunit could be an important therapeutic target for the redirection of ongoing Th cell responses...
  39. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Furthermore, activated B cells fail to migrate from the T cell-rich zone into B cell follicles of the spleen, and despite high numbers of germinal center founder cells, no functional germinal centers develop in this organ...
  40. pmc The effect of magnetic nanoparticles of Fe(3)O(4) on immune function in normal ICR mice
    Bao An Chen
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:593-9. 2010
    ..The results showed that the ratio of spleen to body weight was not different between the experimental groups and control group (P > 0.05)...
  41. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
  42. ncbi Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    M Muramatsu
    Department of Medical Chemistry, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan
    Cell 102:553-63. 2000
    ..AID-/- spleen cells stimulated in vitro with LPS and cytokines failed to undergo class switch recombination although they ..
  43. ncbi RAG-1-deficient mice have no mature B and T lymphocytes
    P Mombaerts
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cell 68:869-77. 1992
    ..Although RAG-1 expression has been reported in the central nervous system of the mouse, no obvious neuroanatomical or behavioral abnormalities have been found in the RAG-1-deficient mice...
  44. doi Lack of the bone morphogenetic protein BMP6 induces massive iron overload
    Delphine Meynard
    INSERM, U563, Toulouse, France
    Nat Genet 41:478-81. 2009
    ....
  45. ncbi Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice
    O Kollet
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 97:3283-91. 2001
    ..immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously conditioned with total body irradiation...
  46. ncbi Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
    F Martin
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 14:617-29. 2001
    The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens...
  47. ncbi A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    Darin K Fogg
    INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France
    Science 311:83-7. 2006
    ..of a mouse bone marrow progenitor that is specific for monocytes, several macrophage subsets, and resident spleen DCs in vivo...
  48. pmc Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
    Masako Kohyama
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 457:318-21. 2009
    ..Spic(-/-) mice show normal trapping of red blood cells in the spleen, but fail to phagocytose these red blood cells efficiently, and develop an iron overload localized selectively to ..
  49. pmc Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Med 15:401-9. 2009
    ..These data define a new mechanism for the systemic induction of retinoic acid and immune suppression against autoimmunity...
  50. ncbi Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infection
    Cynthia L Baldwin
    Paige Laboratory, Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Vet Microbiol 90:367-82. 2002
    ..However, reduction of p40 IL-12 in vivo through administration of indomethacin reduced the infection without a concomitant measurable increase in IFN-gamma. Current studies are aimed at elucidating the mechanism of the IFN-gamma hiatus...
  51. doi The follicular versus marginal zone B lymphocyte cell fate decision
    Shiv Pillai
    Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Rev Immunol 9:767-77. 2009
    ..cells make an important cell fate choice to develop into either follicular B cells or marginal zone B cells in the spleen, which depends on signalling through the B cell receptor, Notch2, the receptor for B cell-activating factor and ..
  52. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  53. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..In chimeric mice reconstituted with CXCR4-deficient fetal liver cells, plasma cells are mislocalized in the spleen, found in elevated numbers in blood, and fail to accumulate normally in the bone marrow...
  54. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  55. ncbi The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
    Natural killer cells are important cytolytic cells in innate immunity. We have characterized human NK cells of spleen, lymph nodes, and tonsils...
  56. ncbi Photonic detection of bacterial pathogens in living hosts
    C H Contag
    Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305 5402, USA
    Mol Microbiol 18:593-603. 1995
    ..In vivo efficacy of an antibiotic was monitored using this optical method. This study demonstrates that real time non-invasive analyses of pathogenic events and pharmacological monitoring can be performed in vivo...
  57. pmc Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells
    H C Probst
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Clin Exp Immunol 141:398-404. 2005
    ..points after diphtheria toxin injection and confirmed the transient depletion of CD11c+ cells from lymph nodes and spleen. Unexpectedly, the injection of diphtheria toxin completely depleted marginal zone and metallophilic M(Phi) from ..
  58. pmc Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8 240 Factor Bldg, 10833 Le Conte Ave, 90095, USA
    J Exp Med 200:437-45. 2004
    ..Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense...
  59. pmc Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    Cevayir Coban
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST, Osaka, Japan
    J Exp Med 201:19-25. 2005
    ..These data suggest that TLR9-mediated, MyD88-dependent, and CQ-sensitive innate immune activation by HZ may play an important role in malaria parasite-host interactions...
  60. pmc B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus
    Michael S Diamond
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Virol 77:2578-86. 2003
    ..Wild-type mice replicated virus extraneuronally in the draining lymph nodes and spleen during the first 4 days of infection...
  61. pmc Stromal cell contributions to the homeostasis and functionality of the immune system
    Scott N Mueller
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia
    Nat Rev Immunol 9:618-29. 2009
    ..is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the ..
  62. ncbi Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures
    Shalin H Naik
    Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 174:6592-7. 2005
    ..This culture system allows access to bona fide counterparts of the splenic DC subsets...
  63. pmc The spleen contributes to stroke-induced neurodegeneration
    Craig T Ajmo
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33216, USA
    J Neurosci Res 86:2227-34. 2008
    ..The immune response that is initiated in the spleen has been linked to the systemic inflammatory response to stroke, contributing to neurodegeneration...
  64. ncbi Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis
    Josianne Nitcheu
    Institut National de la Sante et de la Recherche Medicale, Unité 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, CHU Pitie Salpetriere, Universite Pierre et Marie Curie, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    J Immunol 170:2221-8. 2003
    ..Thus, lymphocyte cytotoxicity and cell trafficking are key players in ECM pathogenesis...
  65. pmc Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection
    Rosario Castro
    Virologie et Immunologie Moléculaires, INRA, Jouy en Josas, France
    PLoS Pathog 9:e1003098. 2013
    ..undertook a comprehensive analysis of the variable heavy chain (VH) domain repertoires of the IgM, IgD and IgT in spleen of homozygous isogenic rainbow trout (Onchorhynchus mykiss) before, and after challenge with a rhabdovirus, the ..
  66. pmc Myeloid suppressor cell depletion augments antitumor activity in lung cancer
    Minu K Srivastava
    Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 7:e40677. 2012
    ..We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer...
  67. pmc Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach
    Hongbo Chen
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, PR China
    BMC Genomics 10:64. 2009
    ..In this study, we investigated the global changes in gene expression in the spleen following HPS infection using the Affymetrix Porcine Genechip.
  68. doi Subsets, expansion and activation of myeloid-derived suppressor cells
    Eliana Ribechini
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, Wurzburg, Germany
    Med Microbiol Immunol 199:273-81. 2010
    ..Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites...
  69. pmc Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development
    Shoichi Suzuki
    Department of Host Defense Biochemistry, Institute of Tropical Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Proc Natl Acad Sci U S A 101:8981-6. 2004
    ..In the IRF-4(-/-) spleen, the number of CD4(+)CD8alpha(-) DCs, a major subset of CD11b(high) DCs, was severely reduced...
  70. ncbi Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: ev
    Rajatava Basu
    Department of Immunology, Indian Institute of Chemical Biology, Kolkata
    J Immunol 174:7160-71. 2005
    ..This is the first report of a vaccine conferring protection to both antimony responsive and resistant Leishmania strains reflecting several aspects of clinical visceral leishmaniasis...
  71. ncbi Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus
    Mauro Krampera
    Department of Clinical, Section of Haematology, University of Verona, Italy
    Bone 40:382-90. 2007
    ..We describe here the neural-like differentiation of human MSCs obtained from spleen and thymus, induced either with chemical factors or with co-culture with human Schwann cells (Sc)...
  72. pmc Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
    ..The amount of macrophages in liver and spleen and peripheral blood leukocyte counts is increased in the ABCA1(-/-) --> LDLr(-/-) chimeras...
  73. ncbi Generation and analysis of interleukin-4 deficient mice
    R Kuhn
    Institute for Genetics, University of Cologne, Germany
    Science 254:707-10. 1991
    ..Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo...
  74. ncbi Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani
    R Lira
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 180:564-7. 1999
    ..No correlation with clinical response was found by use of extracellular promastigotes (ED50=48+/-22 vs. 52+/-29 microgram/mL). The emergence of antimony-resistant L. donovani strains appears to be a cause of treatment failures in India...
  75. pmc Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice
    E A Murphy
    Department of Veterinary and Animal Sciences, Paige Laboratory, University of Massachusetts, Amherst, MA 01003, USA
    Immunology 103:511-8. 2001
    ..5 weeks, the time by which normal BALB/c mice were clearing the infection. Death in both strains of IFN-gamma gene disrupted mice coincided with symptoms of cachexia and macrophages comprised > or= 75% of the splenic leucocytes...
  76. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  77. pmc Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen
    Michele L Caton
    Department of Microbiology, Columbia University Medical Center, New York, NY 10032, USA
    J Exp Med 204:1653-64. 2007
    ..In the spleen, CD8(-) DCs were found adjacent to cells expressing the Notch ligand Delta-like 1 in the marginal zone (MZ)...
  78. pmc Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    Leif E Sander
    Department of Medicine III, RWTH University Hospital, 52074 Aachen, Germany
    J Exp Med 207:1453-64. 2010
    ..Thus, gp130-dependent communication between the liver and MDSCs through APPs controls inflammatory responses during infection...
  79. ncbi Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse
    M G Cecchini
    Department of Pathophysiology, University of Berne, Switzerland
    Development 120:1357-72. 1994
    ..These studies suggest that circulating CSF-1 exclusively regulates both the F4/80+ cells in the liver, spleen and kidney and the MOMA-1+ metallophilic macrophages in the spleen...
  80. pmc Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 105:11008-13. 2008
    ..Here, we show that vagus nerve stimulation during endotoxemia specifically attenuates TNF production by spleen macrophages in the red pulp and the marginal zone...
  81. pmc Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
    Gudrun F Debes
    Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:889-94. 2005
    ..The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation...
  82. ncbi Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice
    Cheng hu Liu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 177:31-5. 2006
    ..Taken together, the results presented in this study indicate that DCs constitute the major IL-12-producing cell population in vivo during T. gondii infection...
  83. ncbi Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential
    Pieternella S In 't Anker
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Haematologica 88:845-52. 2003
    ..We previously found that human fetal lung is a rich source of mesenchymal stem cells (MSC). Here we characterize and analyze the frequency and function of MSC in other second-trimester fetal tissues...
  84. ncbi Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis
    J Alexander
    Department of Immunology, University of Strathclyde, Glasgow, GB
    Eur J Immunol 30:2935-43. 2000
    ..These results demonstrate that IL-4 has an important role in effective anti-leishmanial chemotherapy which seems to be related to modulation of IFN-gamma production...
  85. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  86. doi Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    Kiavash Movahedi
    Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
    Blood 111:4233-44. 2008
    ..Overall, our data refine tumor-induced MDSC functions by uncovering mechanistically distinct MDSC subpopulations, potentially relevant for MDSC-targeted therapies...
  87. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  88. pmc The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity
    Yuchun Nie
    Dept of Microbiology, Columbia University, 701 West 168th St, HHSC 1406, New York, NY 10032, USA
    J Exp Med 200:1145-56. 2004
    ..These findings establish an important role for CXCR4 in regulating homeostasis of B cell compartmentalization and humoral immunity...
  89. ncbi Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes
    Leah A Mitchell
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Toxicol Sci 100:203-14. 2007
    ..expression analysis of selected cytokines and an indicator of oxidative stress were assessed in lung tissue and spleen. No changes in gene expression were observed in lung; however, interleukin-10 (IL-10) and NAD(P)H oxidoreductase 1 ..
  90. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
  91. pmc Autonomic innervation and regulation of the immune system (1987-2007)
    Dwight M Nance
    Susan Samueli Center for Integrative Medicine, University of California Irvine, Orange, CA 92868 4283, USA
    Brain Behav Immun 21:736-45. 2007
    ..Neither the thymus nor spleen receive any sensory neural innervation; however, there is evidence that lymph nodes and bone marrow may be ..
  92. ncbi Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system
    A Krebber
    Biochemisches Institut der Universitat Zurich, Switzerland
    J Immunol Methods 201:35-55. 1997
    ..integrated cloning, screening and selection system allowed us to rapidly obtain antigen binding scFvs derived from spleen-cell repertoires of mice immunized with ampicillin as well as from all hybridoma cell lines tested to date...
  93. pmc A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp
    Martijn A Nolte
    Department of Molecular Cell Biology, VUMC, Amsterdam, Netherlands
    J Exp Med 198:505-12. 2003
    ..Therefore, the conduit plays a role in distribution of both blood-borne and locally produced molecules and provides a framework for directing lymphocyte migration and organization of the splenic white pulp...
  94. ncbi The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    S J Morrison
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 1:661-73. 1994
    ..The ability to predict the longevity of reconstitution based on lineage marker expression indicates that reconstitution potential is deterministic, not stochastic...
  95. ncbi Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets
    H Hochrein
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 166:5448-55. 2001
    ..In contrast, the CD4(-)8(-) DC produced much more IFN-gamma than the CD4(-)8(+) or the CD4(+)8(-) DC under all conditions tested...
  96. pmc Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response
    Cristina L Swanson
    Integrated Department of Immunology, University of Colorado, Denver, CO 80206, USA
    J Exp Med 207:1485-500. 2010
    ..Thus, innate signals have the capacity to enhance TI-2 antibody responses by promoting participation of FO B cells, which then elaborate effective IgG anti-pathogen antibodies...
  97. pmc Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility
    Neil A Mabbott
    Neuropathogenesis Unit, Institute for Animal Health, Edinburgh EH9 3JF, Scotland, United Kingdom
    J Virol 77:6845-54. 2003
    ..scrapie inoculation blocked the early accumulation of infectivity and disease-specific PrP (PrP(Sc)) within the spleen and substantially reduced disease susceptibility...
  98. pmc Follicular shuttling of marginal zone B cells facilitates antigen transport
    Guy Cinamon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 9:54-62. 2008
    ..Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells...
  99. ncbi The induction of anterior chamber-associated immune deviation
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Chem Immunol Allergy 92:27-35. 2007
    ..ACAID embodies a constellation of cellular interactions and at least four different organ systems: eye, thymus, spleen, and sympathetic nervous system...
  100. doi Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells
    Veronica S Mary
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI, CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Córdoba X5000HUA, Argentina
    Toxicology 302:299-307. 2012
    ..This work was aimed at evaluating in spleen mononuclear cells (SMC) from Wistar rats the effects of the exposure, in vitro for up to 48 h, to 20 μM AFB(1), ..
  101. ncbi Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
    Adrian E Morelli
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Blood 104:3257-66. 2004
    ..Circulating exosomes are internalized by DCs and specialized phagocytes of the spleen and by hepatic Kupffer cells...

Research Grants71

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..It is life saving when used on the surfaces of solid visceral organs, such as the liver spleen, pancreas and kidney, involved in trauma, cancer and transplantation in presence of coagulopathies or ..
  3. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..CD11b+ cells and changes in plasma levels of inflammatory cytokines and levels of SNS derived neuropeptide Y in spleen. Corticotrophin releasing hormone (CRH) and melatonin can accelerate arthritis, and although the SNS can increase ..
  4. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..molecule iNOS inhibitor N6(1-iminoethyl)-L-lysine-dihydrochloride (L-NIL) decreases MDSC infiltration in tumor and spleen, reverses the tumor-mediated decrease in CD4+ and CD8+ splenocytes, and enhances the number of tumor-infiltrating ..
  5. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Postmortem studies of DV-infected patients and the AG129 mouse model demonstrate that ECs in the liver, lung, and spleen are infected...
  6. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..CCR7 failed to traffic normally to recipient lymph nodes, and demonstrated a reduced capacity to expand within the spleen. Importantly, however, donor cells lacking CCR7 were able to mount potent anti-cancer immune effects after ..
  7. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..deposits containing the AA amyloid protein in different organs throughout the body including heart, kidney, liver, spleen, lungs, skin and gastrointestinal tract, whereby such amyloid fibril accumulation leads to pronounced organ ..
  8. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Changes in blood and bone marrow cell compositions as well as phagocyte infiltration into lung, spleen and liver will be tested following sepsis or endotoxemia...
  9. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..In mice, Ada KO mutants have no discernable thymus, two-to-three-fold lower cell numbers in the spleen, and livers that exhibit severe histological defects...
  10. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..nephrectomy, laparoscopic liver resection and post-traumatic (hemodynamically stable and non-coagulopathic), spleen laceration...
  11. Immune Development: Role of Milk Cell Transfer and Recipient Gender
    Ameae M Walker; Fiscal Year: 2013
    ..These T cells homed to the spleen and thymus, with maximal accumulation at 3-4 weeks, and disappearance thereafter...
  12. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..immune feature of these mice is the high numbers of Th17 CD4+ T cells, which are spontaneously activated in the spleen. Our data suggest that IL-17 promotes the interaction of B cells and CD4+ T cells in the spleen and the formation ..
  13. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..this "Trojan Horse" MP carriage of the drug formulations can facilitate long-lived storage depots, in liver and spleen, resulting in reduced viral mutation and sustained plasma ART levels...
  14. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    ..and chemokine responses in lung granulomas by laser capture microdissection and real-time RT-PCR as well as whole spleen and lung digest cells following antigen stimulation by real time RT-PCR...
  15. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..to Chinese medical theories, the most common cause of IBS is the "stagnation of liver energy attacking the spleen and resulting in dysfunction of the transportation and transformation function of the spleen"...
  16. A XENOPUS LAEVIS RESEARCH RESOURCE FOR IMMUNOBIOLOGY
    Jacques Robert; Fiscal Year: 2013
    ..g., thymus, spleen) or leukocytes;by developing in vivo knockdown by RNA interference using transgenesis to reveal the function of ..
  17. Understand and Improve Iron Distribution and Erythropoiesis in Beta-Thalassemia
    Yelena Ginzburg; Fiscal Year: 2013
    ..FPN-1B, heme and iron exporters, respectively, during erythroid precursor differentiation in mouse bone marrow and spleen samples as well as in human samples in culture...
  18. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..Some decrease is also observed in the spleen and bone marrow...
  19. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..be used as a drug delivery system to improve tissue penetrance of ART into the reticuloendothelial system (RES;spleen, liver, lymph nodes) in mice...
  20. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
    ..techniques;5) flow cytometry to determine immune cell population in the blood and tissues;6) T cells from the spleen of transgenic mice to determine the mechanism of cPLA2[unreadable]-induced NADPH oxidase activity and ROS ..
  21. Chronic ethanol, B cell competence and lymphoid integrity
    Thomas J Waldschmidt; Fiscal Year: 2010
    ..Of interest, these lesions are accompanied by progressive disruption of lymphoid integrity in the spleen, suggesting alcohol to induce structural damage within secondary lymphoid tissues...
  22. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
    ..and that are individually deformable in a manner to allow them to pass through the 3 micron sized sinusoids in the spleen. Previous approaches for the design of synthetic blood have focused on i) fluorocarbon emulsions which can ..
  23. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The hepatic portal vein carries blood from the intestines, pancreas, spleen and gallbladder and exposes the liver to nutrients and toxins derived from these sources...
  24. The Role of PPAR Gamma in Fat-Resident Regulatory T Cells and Glucose Homeostasis
    SAGAR PRADEEP BAPAT; Fiscal Year: 2013
    ..A recent study showed that fTregs have a different gene expression signature compared to Tregs isolated from the spleen or lymph nodes in mice...
  25. Mechanistic study of the host defense functions of IL-32 in tuberculosis
    Edward D Chan; Fiscal Year: 2013
    ..hypervirulent MTB W-Beijing HN878 showed that the SPC-IL-323Tg mice have reduced bacterial burden in the lungs and spleen, a more protective immune phenotype, and increased survival compared to wild type (WT) C57BL/6 mice...
  26. The Role of Fibrocytes in Liver Fibrosis
    Tatiana Kisseleva; Fiscal Year: 2012
    ..fibrocytes possess high plasticity, and in response to liver injury migrate to fibrotic liver, but also to spleen where they mediate antimicrobial response...
  27. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..will include blood chemistry, enzyme activity, and RNA and protein expression analysis of plasma, liver, spleen and kidney, plus histopathology of these organs...
  28. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..The iGb3 synthase knockout (iGb3S-/-) mice furthermore showed normal iNKT cells numbers in the thymus, spleen, and liver...
  29. Syk in Mitochondrial Stress Signaling and Insulin Resistance
    Heide Christine Patterson; Fiscal Year: 2013
    ..The prevailing notion is that spleen tyrosine kinase (Syk) is a kinase important for activation of B cells, myeloid cells and other cell of the ..
  30. Immune Regulation of Virus Clearance and Tissue Injury at Sites of Infection
    Thomas J Braciale; Fiscal Year: 2013
    ..e. the spleen, and the activation state of the NK cells, affect virus elimination and the tempo and quality of the antiviral CD8 ..
  31. The Effects of C-Reactive Protein on Autoimmunity
    Terry W Du Clos; Fiscal Year: 2013
    ..We have produced suppressive macrophages by treating spleen cells, splenic macrophages or bone marrow macrophages (BMM) with CRP...
  32. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..moves from the yolk sac of the embryo to the embryo dorsal aorta to the fetal liver, then to the fetal spleen and finally to the bone marrow...
  33. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..exposure of New Zealand White rabbits to the isolate resulted in severe eye disease and necrosis of the spleen and lymph nodes...
  34. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..Analyses of numbers, location, and proportions of regulatory T cell (Treg) subsets (from lamina propria and spleen) as well as their ability to inhibit lymphocyte proliferation will e employed to test hypotheses that ENS ..
  35. Regulation of Osteoblast Function by Megakaryocytes: Key Signaling Proteins
    Melissa A Kacena; Fiscal Year: 2013
    ..Importantly, the increased bone phenotype can be adoptively transferred into irradiated wild-type mice using spleen cells from mutant mice suggesting a role for hematopoietic cells, most likely MKs which are elevated in these mice,..
  36. Study of the HFE Transferrin Receptor interaction in mammalian iron homeostasis
    Paul Schmidt; Fiscal Year: 2010
    ..Liver iron stores will be used as an index of intestinal iron absorption, and serum transferrin saturation and spleen iron stores will be used to assess macrophage iron recycling and stores...
  37. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..in the Peyer[unreadable]s patches, which then carry the infection to other organs including the liver and the spleen. This results in either systemic disease, clearance of the organism, or an asymptomatic carrier state in which ..
  38. Tissue compartmentalization of human lymphocytes
    Donna L Farber; Fiscal Year: 2013
    ..Thus far, we have analyzed T cells from blood and eight different tissues including lymphoid tissues (spleen, peripheral and tissue-draining lymph nodes), and mucosal tissues (lung, small and large intestines) from over 24 ..
  39. MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORS
    Hal E Broxmeyer; Fiscal Year: 2013
    ..cycling status of functionally- and phenotypically-defined HSC and HPC in fetal liver, and adult bone marrow and spleen, and on mature blood cell lineages in blood, bone marrow and spleen using Sirt1 -/-, Sirt1 +/-, and littermate ..
  40. Role of cannabinoid 2 receptors in B lymphocyte function
    Catherine E Patterson; Fiscal Year: 2010
    ..switching will be determined by ELISA of serum samples and by examining T helper biasing cytokine production in spleen and lymph node cells from injected mice...
  41. Adipose Tissue Macrophage Iron Metabolism in Obesity
    Alyssa H Hasty; Fiscal Year: 2013
    ..In other organs, liver and spleen in particular, macrophages play a key role in iron homeostasis...
  42. Oxidative Stress and Autoimmunity
    M Firoze Khan; Fiscal Year: 2013
    ..Formation of LPDA-protein adducts (in liver, kidney and spleen) and their corresponding antibodies will be correlated with autoimmune response...
  43. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven L Spitalnik; Fiscal Year: 2012
    ..mouse model demonstrate that the transfusion of older stored RBC acutely delivers hemoglobin iron to the spleen, kidney, and liver, induces an intense pro-inflammatory cytokine response, and synergizes with the effects of ..
  44. Functional impact of dendritic cell phenotype in a mouse model of myositis
    Dana P Ascherman; Fiscal Year: 2010
    ..T cell proliferative responses and intracellular cytokine staining of antigen-challenged lymphocytes derived from spleen and organ-draining lymph nodes of DC-immunized mice will further link the observed tissue phenotype to Th17 and/or ..
  45. CELLULAR MECHANISMS OF PTLD IN TRANSPLANT RECIPIENTS
    Olivia M Martinez; Fiscal Year: 2012
    ..We have also determined that the spleen tyrosine kinase (Syk), activated by the viral protein latent membrane protein 2A (LMP2A), is critical to the ..
  46. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..ability to expand HSCs in culture, to determine whether similar cells are found in the adult mouse bone marrow and spleen, to determine whether these are part of the HSC niche, and to examine differences and similarities between gene ..
  47. MECHANISMS OF THE INDUCTION OF ORAL TOLERANCE
    Howard L Weiner; Fiscal Year: 2013
    ..AHR have a defect in the induction of oral tolerance and a defect in Tregs in the mesenteric lymph node but not spleen or thymus. Furthermore, in addition to its effect on T cells, the AHR ligand ITE affects dendritic cells (DCs)...
  48. IL12 Gene Therapy For Enhancing Therapeutic Efficacy of Bleomycin Against Oral Tu
    Shulin Li; Fiscal Year: 2013
    ..study in mice also found that injection of bleomycin via intratumoral electroporation may decrease the size of the spleen, but that this side effect is able to be reversed by co-administration IL12 encoding DNA via electroporation...
  49. Role of Brain-Specific microRNAs in Suppression of Autoimmune Neuroinflammation
    Howard L Weiner; Fiscal Year: 2013
    ..in normal CNS-resident macrophages, but not in inflammatory macrophages or normal macrophages isolated from blood, spleen, bone marrow, peritoneal cavity or liver...
  50. Aldose Reductase: A Regulator of Inflammatory Signals
    KOTA VENKATA RAMANA; Fiscal Year: 2011
    ..of LPS-induced inflammatory cytokines and chemokines by AR inhibition will be investigated in the liver, spleen, small intestine, kidney, heart and serum, and correlated with attenuation of inflammation in tissues of mice...
  51. Neuropeptides and Regulatory T cells
    Doina Ganea; Fiscal Year: 2013
    ..We will assess LentiVIP-DC migration to spleen, CNS, and affected joints, and investigate the effects on clinical disease, on splenic and local cytokine/..
  52. Quinone Oxidoreductases and Mammary Toxicity/Carcinogenenicity
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..led to mammary gland intraductal hyperplasia and DMBA-induced mammary tumors that metastasized to lung, liver and spleen. NQO2 is highly homologous to NQO1 and is also expected to protect against mammary cancer...
  53. Sex differences in brain inflammation in experimental stroke
    Halina Offner; Fiscal Year: 2013
    ..biological sex, including sexually dimorphic immune cell subsets and key inflammatory mechanisms that affect brain-spleen-brain cycling of inflammatory cells after focal cerebral ischemia...
  54. IMMUNE RESPONSES IN LUPUS
    Joseph Craft; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: T cells that help B cells produce antibodies in the spleen and other lymphoid organs are critical for normal and autoimmune responses...
  55. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..Subsequently, there is a progressive apoptosis of the spleen, with broad destruction of most constituent immunologically competent cells but a sparing of Treg cells...
  56. CHARACTERIZATION OF NOVEL BUTADIENE-INDUCED PUTATIVE p53 TARGET GENES
    Perpetua M Muganda; Fiscal Year: 2010
    ..range of hematopoietic, reproductive, and neurological toxicity, which includes bone marrow depletion, ovarian, spleen and thymus atrophy...
  57. Genetic and Transcriptional Control of Spleen Development
    Licia Selleri; Fiscal Year: 2013
    ..In this proposal, we will use the vertebrate spleen as a model to investigate these fundamental steps...
  58. Chronic alcohol abuse disrupts CD8+T cell function
    Annette J Schlueter; Fiscal Year: 2013
    ..Published work from our laboratories and others has shown comparable findings in CD8+ T cells from mouse spleen, after many weeks of 20% (w/v) ethanol in water ingestion...
  59. Validating Syk as a Target for AML Therapy
    Kimberly Stegmaier; Fiscal Year: 2013
    ..b>Spleen tyrosine kinase (Syk) was identified as the top candidate...
  60. MicroRNA expression in the NZB/W lupus mouse
    CHRISTOPHER MICHAEL REILLY; Fiscal Year: 2013
    ..2. Correlate the changes in miRNA expression to pathological changes in the kidney and spleen to detail how miRNA expression parallels disease activity...
  61. Function of MTG16/ETO2 in acute leukemia
    SCOTT HIEBERT; Fiscal Year: 2010
    ..Moreover, the Mtg16-null stem cells and progenitor cells were completely defective in spleen colony forming assays...
  62. The role of Atg16L1 in Graft-Versus-Host-Disease
    VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2013
    ..organ damage and lymphocytic infiltration via Flow Cytometry and histology of various GVHD target organ tissues (spleen, thymus, liver, skin, small intestines and colon)...
  63. NEMATODE-INDUCED PULMONARY GRANULOMA FORMATION
    STEPHEN KAYES; Fiscal Year: 1991
    ..All attempts to transfer granulomatous hypersensitivity from infected mice to naive recipients using spleen cells or hyperimmune serum from infected mice have failed...
  64. BETA-GLUCOSIDASES IN GAUCHER DISEASE
    Robert Glew; Fiscal Year: 1991
    ..It is as designated because of its subcellular location in liver and spleen and because it hydrolyzes a variety of glycosides, including Beta-D-glucosides, Beta-D-galactosides and alpha-L-..
  65. VIRAL GASTROENTERITIS--BASIS OF PROTECTION AND VIRULENCE
    Harry Greenberg; Fiscal Year: 2003
    ..more efficiently than heterologous infection, we will characterize the T helper cell response in the gut and spleen after murine and non-murine rotavirus infection of suckling mice...
  66. Intercellular transfer of prion in prion disease
    Man Sun Sy; Fiscal Year: 2006
    ..in cattle, it is believed that the PrP sc enters the host through the gastrointestinal tract, migrates to the spleen, and eventually causes disease in the CNS...
  67. Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesis
    Samuel Black; Fiscal Year: 2009
    ..in the mouse model show that there is a rapid expansion of early B cell progenitors in the bone marrow and spleen, but the loss of newly formed and mature B cells from these organs, features of dyshematopoiesis that are reversed ..
  68. SURGERY AND IV NUTRITION MODULATE MACROPHAGE FUNCTION
    W Helton; Fiscal Year: 1999
    ..Mphis will be isolated from the mesenteric lymph nodes, peritoneal cavity, lung, and spleen and their function studied...
  69. DIFFERENT IMBALANCES OF CYTOKINES IN NEMATODE INFECTIONS
    Norman Reed; Fiscal Year: 1992
    ..In cultures of normal bone marrow, medium conditioned (CM) by spleen cells of normal mice (Nor-CM) or Ts-or Nb-infected mice (Ts-CM or Nb-CM) supports the development of mast cells ..
  70. Manufacturing Process for Albumin-ICG Solder & Denatured Albumin Scaffold
    Yasmin Wadia; Fiscal Year: 2006
    ..biomaterials to join, repair and create hemostasis on surfaces of solid visceral organs such as the liver, spleen and kidney involved in trauma, cancer, and transplantation in the presence of dilutional coagulopathies or ..
  71. CHRONIC INFUSION OF OPIOID PEPTIDES AND IMMUNE RESPONSES
    SEI TOKUDA; Fiscal Year: 1990
    ..buy plaque-forming cell and cytotoxic T-cell assays following immunization, natural killer cell activation, and spleen cell proliferation following mitogen stimulation...