apocrine glands

Summary

Summary: Large, branched, specialized sweat glands that empty into the upper portion of a HAIR FOLLICLE instead of directly onto the SKIN.

Top Publications

  1. ncbi Apocrine secretory mechanism: recent findings and unresolved problems
    A P Gesase
    Department of Anatomy Histology, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Histol Histopathol 18:597-608. 2003
  2. ncbi Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
    J Am Acad Dermatol 57:467-83. 2007
  3. ncbi Ablation of apocrine glands with the use of a suction-assisted cartilage shaver for treatment of axillary osmidrosis: an analysis of 156 cases
    Wen Horng Wu
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Kuang Tien General Hospital, Hungkuang University, Taichung, Taiwan
    Ann Plast Surg 62:278-83. 2009
  4. ncbi Radical treatment of axillary osmidrosis by subdermal excision of apocrine glands: a prospective study in 31 cases
    J G Qian
    Department of Plastic Surgery, Zhejiang Provincial Tongde Hospital, 234 Gucui Road, Hangzhou 310012, China
    J Plast Reconstr Aesthet Surg 59:860-4. 2006
  5. ncbi Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ
    Z Gatalica
    Department of Pathology, The University of Texas Medical Branch at Galveston, 77555 0588, USA
    Pathol Res Pract 193:753-8. 1997
  6. ncbi Effectiveness and complications of subdermal excision of apocrine glands in 206 cases with axillary osmidrosis
    J G Qian
    Department of Plastic Surgery, Zhejiang Provincial Tongde Hospital, 234 Gucui Road, Hangzhou 310012, China
    J Plast Reconstr Aesthet Surg 63:1003-7. 2010
  7. ncbi Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases
    Alistair Robson
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Am J Surg Pathol 32:682-90. 2008
  8. ncbi Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?
    Yu Toyoda
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B 60 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    FASEB J 23:2001-13. 2009
  9. ncbi Immunocytochemical localization of lysozyme and beta-defensin in the apocrine glands of the equine scrotum
    Tadashi Yasui
    Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252 8510, Japan
    Arch Dermatol Res 299:393-7. 2007
  10. ncbi Dilation of apocrine glands. A forgotten but helpful histopathological clue to the diagnosis of axillary Fox-Fordyce disease
    Ricardo S Macarenco
    Department of CIPAX Medicina Diagnostica, Sao Jose dos Campos SP, Brazil
    Am J Dermatopathol 31:393-7. 2009

Research Grants

Detail Information

Publications211 found, 100 shown here

  1. ncbi Apocrine secretory mechanism: recent findings and unresolved problems
    A P Gesase
    Department of Anatomy Histology, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Histol Histopathol 18:597-608. 2003
    ..In other glands morphological features during apocrine secretion have not been documented. The current paper reviews what is known about apocrine secretion, recent findings and highlights on the unresolved areas for future research...
  2. ncbi Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
    J Am Acad Dermatol 57:467-83. 2007
    ..A systematic analysis of the entire spectrum of various forms of differentiation and metaplastic epiphenomena in cutaneous apocrine mixed tumor (AMT) has never been performed...
  3. ncbi Ablation of apocrine glands with the use of a suction-assisted cartilage shaver for treatment of axillary osmidrosis: an analysis of 156 cases
    Wen Horng Wu
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Kuang Tien General Hospital, Hungkuang University, Taichung, Taiwan
    Ann Plast Surg 62:278-83. 2009
    ..1% (16/312). There were no recurrent malodor, contracture scars, arm abduction limitation, or any nerve injury in our series. The minor procedure can be an efficient and predictable treatment choice for axillary osmidrosis...
  4. ncbi Radical treatment of axillary osmidrosis by subdermal excision of apocrine glands: a prospective study in 31 cases
    J G Qian
    Department of Plastic Surgery, Zhejiang Provincial Tongde Hospital, 234 Gucui Road, Hangzhou 310012, China
    J Plast Reconstr Aesthet Surg 59:860-4. 2006
    ..5%) patients were very satisfied with the procedure and two (6.5%) patients satisfied, with none regretful. The operation has the advantage of a high success rate in radical elimination of the malodour with minor complications...
  5. ncbi Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ
    Z Gatalica
    Department of Pathology, The University of Texas Medical Branch at Galveston, 77555 0588, USA
    Pathol Res Pract 193:753-8. 1997
    ..An identical pattern of immuno-reactivity is seen in in situ apocrine carcinomas, but it is observed with less frequency in invasive apocrine carcinomas, which only infrequently express AR as the only steroid hormone receptor...
  6. ncbi Effectiveness and complications of subdermal excision of apocrine glands in 206 cases with axillary osmidrosis
    J G Qian
    Department of Plastic Surgery, Zhejiang Provincial Tongde Hospital, 234 Gucui Road, Hangzhou 310012, China
    J Plast Reconstr Aesthet Surg 63:1003-7. 2010
    ..Open excision of the subcutaneous apocrine glands through a small incision seems to be the most logical and effective method available for osmidrosis...
  7. ncbi Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases
    Alistair Robson
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Am J Surg Pathol 32:682-90. 2008
    ..Furthermore, steroid receptor expression should be investigated in these tumors, particularly if a tumor is unlikely to be controlled by surgery alone...
  8. ncbi Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?
    Yu Toyoda
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B 60 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    FASEB J 23:2001-13. 2009
    ..For rapid genetic diagnosis of axillary osmidrosis and potential risk of breast cancer, we developed specific primers for the SmartAmp method that enabled us to clinically genotype the ABCC11 gene within 30 min...
  9. ncbi Immunocytochemical localization of lysozyme and beta-defensin in the apocrine glands of the equine scrotum
    Tadashi Yasui
    Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252 8510, Japan
    Arch Dermatol Res 299:393-7. 2007
    The present study revealed in detail the subcellular localization of lysozyme and beta-defensin in the apocrine glands of the equine scrotal skin, a specific body region...
  10. ncbi Dilation of apocrine glands. A forgotten but helpful histopathological clue to the diagnosis of axillary Fox-Fordyce disease
    Ricardo S Macarenco
    Department of CIPAX Medicina Diagnostica, Sao Jose dos Campos SP, Brazil
    Am J Dermatopathol 31:393-7. 2009
    ..We also propose that the so-called perifollicular xanthomatosis may be composed of muciphages or mixed cell (muciphages/xanthomatous) population, an issue that should be further investigated in future studies...
  11. ncbi Solid apocrine carcinoma of the skin: report of a rare adnexal neoplasm mimicking lobular breast carcinoma
    Bettina G Zelger
    Institute of Pathology, Innsbruck Medical University, Innsbruck, Austria
    J Cutan Pathol 35:332-6. 2008
    ..A survey of the stereotypical presentation of this lesion and a comparison with lobular breast carcinoma and other types of apocrine carcinoma of the skin is given...
  12. ncbi Extramammary Paget Disease of the Axilla Associated With Comedo-like Apocrine Carcinoma In Situ
    Elena Castelli
    Institute of Pathology, University of Palermo, Palermo, Italy
    Am J Dermatopathol 24:351-7. 2002
    ..This reinforces the unifying conception of Paget disease...
  13. ncbi Three-millimeter apocrine adenoma in a man: a case report and review of the literature
    Melissa A Pasquale-Styles
    Departments of Pathology, Jackson Memorial Hospital, Miami, Fla, USA
    Arch Pathol Lab Med 127:1498-500. 2003
    ..After reviewing other reported apocrine adenomas in the literature, we determined that our case was the smallest detected apocrine adenoma to be reported to date...
  14. doi Deciduoid-like myofibroblastoma of the breast: a potential pitfall of malignancy
    G Magro
    Histopathology 52:652-4. 2008
  15. ncbi Androgen and estrogen receptor mRNA status in apocrine carcinomas
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Patholology, Washington, DC 20306 6000, USA
    Diagn Mol Pathol 11:113-8. 2002
    ..Therefore, the immunohistochemical absence of the estrogen receptor in apocrine cells cannot be explained by an abnormal message at these common sites and should be sought beyond these points...
  16. ncbi Mixed apocrine sweat gland tumor of the tail in a cow
    M Y Gulbahar
    Department of Pathology, Faculty of Veterinary Medicine, University of Yuzuncu Yil, Zeve Kampusu, Turkey
    Vet Pathol 39:281-5. 2002
    ..Immunostaining for neuron-specific enolase and S100 protein was not observed in any component of the tumor mass. These findings suggested that the origin of bone formation was undifferentiated mesenchymal cells with osteogenic potential...
  17. ncbi A rare and unusual case of bilateral, axillary, metachronous apocrine carcinoma
    Santosh K Somasundaram
    West Middlesex University Hospital, Breast and General Surgery Department, Twickenham Road, Isleworth, Middlesex TW7 6AF, UK
    Int Surg 92:335-8. 2007
    ..He had a further recurrence in the right axilla and was treated with surgery and radiotherapy. He continues to do well at this time, with no evidence of local or distant metastases...
  18. ncbi Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia
    Tatjana Bujas
    Department of Pathology, Karlovac General Hospital, Ljudevit Jurak Department of Pathology, Sestre Milosrdnice University Hospital, Vinogradska cesta 29, HR 10000 Zagreb, Croatia
    Acta Dermatovenerol Croat 15:148-51. 2007
    ..Beneath the tumor, in the deep dermis and subcutaneous tissue, hyperplastic apocrine glands were also found...
  19. ncbi Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma)
    Joan Cangiarella
    Department of Pathology, New York University Medical Center, 550 First Avenue, Skirball West Tower, Suite 7S, New York, NY 10016, USA
    Diagn Cytopathol 26:320-3. 2002
    ..Herein, we describe a second case with cytologic, histologic, and immunohistochemical findings and discuss the differential diagnosis of foamy cells on aspiration smears obtained from mammary nodules...
  20. ncbi Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles
    Sonja Ständer
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:42-51. 2002
    ..In conclusion, preserved MC-1R expression in adnexal epithelia suggests a functional role of proopiomelanocortin (POMC) in various malformations and neoplasms of the skin...
  21. ncbi Use of quantitative analysis as a method for differentiation between canine cutaneous apocrine adenomas and apocrine carcinomas on cytological smears
    R S Simeonov
    Department of General and Clinical Pathology of Animals, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
    J Vet Med A Physiol Pathol Clin Med 54:542-4. 2007
    ..The results indicated that the computerized morphometry could be used as an effective auxiliary tool for differential diagnosis between canine cutaneous adenomas and carcinomas on cytological smears...
  22. ncbi Structure and function of human sweat glands studied with histochemistry and cytochemistry
    Kenji Saga
    Department of Dermatology, Sapporo Medical University School of Medicine, Minami 1 Nishi 16, Chyuo ku, Sapporo 060 8543, Japan
    Prog Histochem Cytochem 37:323-86. 2002
    ..Histochemical techniques, especially immunohistochemistry using a confocal laser scanning microscope and in situ hybridization, will further clarify the relationship of the structure and function in human sweat glands...
  23. ncbi An unusual apocrine carcinoma on the forehead
    Noriyuki Misago
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Am J Dermatopathol 29:404-7. 2007
    ..Otherwise, it could be a hitherto undescribed variant of apocrine carcinoma. This apocrine carcinoma on the forehead may have originated from either pluripotential cells or from apocrine glands at an unusual site.
  24. ncbi Tubular apocrine adenoma in association with syringocystadenoma papilliferum
    Fatma Aktepe
    Department of Pathology, Afyon Kocatepe University School of Medicine, Afyon, Turkey
    Dermatol Online J 9:7. 2003
    ..It was difficult to distinguish stromal cells and epithelial cells from each other in some areas. The characteristics and differences in histopathologic and immunohistochemical findings in these tumors are described...
  25. ncbi An unusual axillary mass
    David C Huneycutt
    Am J Med 115:677-9. 2003
  26. ncbi Recurrent pleural effusion and pulmonary metastases from a cutaneous apocrine tumour of the axilla
    S Guerriero
    Surgical Unit, Ospedale S Martino, Belluno, Italy
    Acta Chir Belg 107:697-9. 2007
    ..We describe the clinical and histological features, with management options and a review of the relevant literature on apocrine gland carcinoma...
  27. ncbi Axillary apocrine carcinoma with brain metastases
    Elisa Gallerani
    Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    J Clin Oncol 25:5655-6. 2007
  28. ncbi The expression of CD23 in cutaneous non-lymphoid neoplasms
    Jason Carvalho
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Cutan Pathol 34:693-8. 2007
    ..Its utility in cutaneous epithelial tumors has never been studied. In our routine practice, we observed that CD23 reacted strongly with eccrine and apocrine secretory coils...
  29. ncbi A case of ductal apocrine carcinoma in the left axilla with tubular apocrine adenoma in the right axilla
    Yasuyuki Amo
    Department of Dermatology, Inada Noborito Hospital, Kanagawa, Japan
    J Dermatol 30:72-5. 2003
  30. ncbi Apocrine cystadenoma and apocrine hidrocystoma: examination of 21 cases with emphasis on nomenclature according to proliferative features
    Akiko Sugiyama
    Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Cutan Pathol 34:912-7. 2007
    Apocrine cystadenoma (AC) and apocrine hidrocystoma (AH) have been used interchangeably in the literature to designate cystic lesions of apocrine glands.
  31. ncbi Apocrine carcinomas of the breast in Turkish women: hormone receptors, c-erbB-2 and p53 immunoexpression
    Handan Kaya
    Department of Pathology, Marmara University Hospital, Altunizade, Istanbul 81190, Turkey
    Pathol Res Pract 204:367-71. 2008
    ..For Turkish BCa patients, (i) the occurrence rate of ApBCa (2.1%) was high; and (ii) the following combination would allow for an immunohistochemical identification of ApBCa: GCDFP-15(+), c-erbB-2(+), and PR(-)...
  32. ncbi Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case
    Masayuki Shintaku
    Department of Pathology, Osaka Red Cross Hospital, Osaka, Japan
    Pathol Int 52:169-73. 2002
    ..This case emphasizes that apocrine adenocarcinomas of the ocular region have the potential for aggressive biological behavior, including distant metastasis...
  33. ncbi A case of sebaceoma with extensive apocrine differentiation
    Jin Tanahashi
    Department of Pathology, Faculty of Medicine, Oita University, Yufu Shi, Oita, Japan
    Am J Dermatopathol 30:408-11. 2008
    ..Nuclear atypia of all types of cells was inconspicuous, and mitotic figures were infrequent. We considered the lesion to be a sebaceoma with apocrine differentiation...
  34. ncbi Apocrine adenocarcinoma in a golden hamster
    F Urayama
    Department of Veterinary Pathology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 63:1249-52. 2001
    ..By electron microscopy, the tumor cells had an oval nucleus with invagination, abundant cytoplasmic organelles and microvilli protruding into the intercellular spaces...
  35. ncbi Squamous cell apocrine hidradenoma
    Jorge Angulo
    Department of Dermatology, Fundacion Jimenez Diaz, Universidad Autonoma, Avenida Reyes Catolicos 2, 28040 Madrid, Spain
    J Cutan Pathol 34:801-3. 2007
    ....
  36. pmc Axillary apocrine carcinoma with benign apocrine tumours: a case report involving a pathological and immunohistochemical study and review of the literature
    T Miyamoto
    Division of Dermatology, Tsuyama Central Hospital, 1756 Kawasaki, Tsuyama 708 0841, Japan
    J Clin Pathol 58:757-61. 2005
    ..Apocrine carcinoma is rare and often occurs in the axilla. This is the second apocrine carcinoma arising in bilateral axillae with associated apocrine hyperplasia to be reported...
  37. ncbi [Organoid nevus (nevus sebaceus) dominated by the apocrine glands]
    Lone Baandrup
    Amtssygehuset i Gentofte, Patologisk anatomisk Institut og Dermatovenerologisk Afdeling
    Ugeskr Laeger 167:2900-1. 2005
    We report a case of congenital organoid nevus with an excessive number of apocrine glands. A one-year-old boy presented with a slowly enlarging keratotic element in the left temporal region, and biopsy showed hyperkeratosis, acanthosis, ..
  38. ncbi Adenocarcinoma of apocrine sweat glands in a mouflon (Ovis musimon)
    Federico Morandi
    Department of Veterinary Public Health and Animal Pathology, School of Veterinary Medicine, Bologna, Italy
    J Vet Diagn Invest 17:389-92. 2005
    ..On the basis of histological and ultrastructural findings, this tumor was diagnosed as a tubulopapillary adenocarcinoma, arising from apocrine sweat glands of the skin...
  39. ncbi Benign pigmented apocrine vulvar hamartomas
    S M Stephens-Groff
    Pediatric Ambulatory Care Clinic, Children's Health Center, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013
    Pediatr Dermatol 10:123-4. 1993
    ..To our knowledge, these rare and benign tumors have never been described as pigmented, but should be added to the differential diagnosis of pigmented vulvar lesions...
  40. ncbi [Expansion of an ceruminous adenoma into the middle ear]
    M Teschner
    Medizinische Hochschule Hannover, Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, 30625 Hannover
    Laryngorhinootologie 85:444-7. 2006
    ..Owing to a high recurrence rate, complete surgical removal is necessary. Despite its rare occurrence, a ceruminal gland adenoma must be taken into consideration in the differential diagnosis of individual cholesteatoma cases...
  41. ncbi Bilateral axillary apocrine nevi--a case report
    Gayathri P Amonkar
    Department of Pathology, T N Medical College and B Y L Nair Hospital, Dr A L Nair Road, Bombay Central, Mumbai
    Indian J Pathol Microbiol 48:22-3. 2005
    b>Apocrine glands are tubular glands, which function as scent glands. These are found at only a few sites like the axillae and anogenital region...
  42. ncbi Expression of androgen receptors and inhibin/activin alpha and betaA subunits in breast apocrine lesions
    Hyo Sub Shim
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    APMIS 114:352-8. 2006
    ..271, p=0.0048). As the expression of the alpha and betaA subunits reflects inhibin and activin A, respectively, AR and activin A may be implicated in apocrine morphogenesis, but not in tumor progression...
  43. ncbi Lipomatous pleomorphic adenoma of the ceruminous gland
    Hiroko Kuwabara
    Department of Pathology, School of Medicine, Osaka Medical College, Osaka, Japan
    Pathol Int 56:51-3. 2006
    ..This case demonstrates the peculiar location of a lipomatous pleomorphic adenoma in the external auditory canal...
  44. ncbi Syringocystadenoma papilliferum associated with apocrine poroma
    Toshihiro Suzuki
    Department of Dermatology, Dokkyo University of School of Medicine, Mibu, Japan
    J Dermatol 33:249-51. 2006
    ..Based on these findings, a diagnosis of SCAP associated with apocrine poroma was made. To the best of our knowledge, there have been no previous reports of such a case in the published work...
  45. ncbi CD10 expression in cutaneous adnexal neoplasms and a potential role for differentiating cutaneous metastatic renal cell carcinoma
    Soon Bahrami
    Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Arch Pathol Lab Med 130:1315-9. 2006
    ..The differential diagnosis in histopathologic evaluation of these cases includes cutaneous adnexal neoplasms, and describing the expression of CD10 in these tumors may be helpful in delineating the differential diagnosis...
  46. pmc Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature
    K N MacNeill
    Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario M9G 1L5, Canada
    J Clin Pathol 58:217-9. 2005
    ..This report describes the case of an invasive apocrine adenocarcinoma arising in a benign adenoma in the perianal region of a 45 year old woman. The origin and invasiveness are supported by histological and immunohistochemical studies...
  47. pmc Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast
    C Jones
    Breast Molecular Pathology Group, Department of Histopathology, Royal Free and University College Medical School, University College London, London, United Kingdom
    Am J Pathol 158:207-14. 2001
    ..These alterations are also commonly seen in nonapocrine breast cancer. The data are consistent with apocrine hyperplasia as a putative nonobligate precursor of apocrine carcinoma...
  48. ncbi Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature
    Brian Pucevich
    Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA, USA
    Dermatol Online J 14:5. 2008
    ..To our knowledge this is the first reported case of apocrine adenocarcinoma to develop in an accessory nipple...
  49. ncbi Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinicopathologic study of 18 cases
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic
    Am J Surg Pathol 31:1094-102. 2007
    ..We conclude that some atypical cytoarchitectural features in apocrine mixed tumors, albeit worrisome, do not indicate a malignant change...
  50. ncbi Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands
    Wataru Nishie
    Department of Dermatology, Sapporo Social Insurance General Hospital, Chuo2 6 2 1, Atsubetsu ku, Sapporo 004 8618, Japan
    J Cutan Pathol 31:561-4. 2004
    ..In this study, it has been suggested that this tumor might have been developed from these mammary-like glands...
  51. ncbi Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation
    Mohamed E Salama
    Department of Pathology, Henry Ford Hospital, Detroit, Mich 48202, USA
    Arch Pathol Lab Med 128:986-90. 2004
    ..Chondroid syringoma (CS) is a benign cutaneous adnexal tumor with epithelial and stromal components. Epithelial components derived from folliculo-sebaceous-apocrine germ are evident in apocrine but not in eccrine CS...
  52. ncbi Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread
    Jonathan M Hernandez
    Department of Surgery, University of South Florida, Tampa, Florida 33612, USA
    Am Surg 73:307-9. 2007
    ..Wide local excision with lymph node dissection is the mainstay of treatment. The role of adjuvant therapy has yet to be established...
  53. ncbi [A case of apocrine adenocarcinoma suspected as an axillary lymph node metastasis from cecal cancer]
    Takayuki Ogino
    Dept of Gastrointestinal Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
    Gan To Kagaku Ryoho 33:1968-70. 2006
    ..Histopathological examination showed the axillary tumor was different from the cecal cancer. Axillary tumor was diagnosed not as metastasis of axillary lymph nodes from cecal cancer but apocrine adenocarcinoma...
  54. ncbi Mucinous carcinoma of the skin could have either an eccrine or an apocrine origin
    H Mitsui
    Br J Dermatol 151:1285-6. 2004
  55. ncbi Moll gland neoplasms of the eyelid: a clinical and pathological spectrum in 5 cases
    Ann E Barker-Griffith
    Eye Pathology Laboratory, Weiskotten Hall, Room 2107, State University of New York Upstate Medical University, 766 Irving Ave, Syracuse, NY 13210, USA
    Arch Ophthalmol 124:1645-9. 2006
  56. ncbi Cytologic features of pleural effusion in apocrine sweat gland carcinoma. A case report
    M Otani
    Division of Pathology, Tokyo Medical University Hospital and Toho University Hospital, and Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Acta Cytol 45:74-8. 2001
    ..Moreover, its definitive diagnosis in a pleural effusion can be made because of retaining the characteristics of apocrine sweat gland...
  57. ncbi Surgical approach to extensive hidradenitis suppurativa in the perineal/perianal and gluteal regions
    Emre Balik
    Department of General Surgery, University of Istanbul, Istanbul Faculty of Medicine, Istanbul, Turkey
    World J Surg 33:481-7. 2009
    ..It is a disease of the apocrine sweat glands and may arise from each of the localizations where apocrine glands are prominent: axilla, nipples, umbilicus, perineum, groin, and buttocks...
  58. ncbi Hypohidrotic ectodermal dysplasia with true anodontia of the primary dentition
    Aydan Acikgoz
    Department of Oral Diagnosis and Radiology, Faculty of Dentistry, University of Baskent, Ankara, Turkey
    Quintessence Int 38:853-8. 2007
    ..An armpit biopsy specimen revealed the absence of eccrine and apocrine glands. A removable prosthesis was made to satisfy the patient's esthetic and functional needs...
  59. ncbi Dependence of humoral hypercalcemia of malignancy on parathyroid hormone-related protein expression in the canine anal sac apocrine gland adenocarcinoma (CAC-8) nude mouse model
    A Grone
    Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA
    Vet Pathol 35:344-51. 1998
    ..factor in dogs with spontaneous humoral hypercalcemia of malignancy (HHM) and adenocarcinomas derived from apocrine glands of the anal sac...
  60. ncbi Toll-like receptor 2 is highly expressed in lesions of acne inversa and colocalizes with C-type lectin receptor
    R E Hunger
    Department of Dermatology, University of Bern, Inselspital, 3010 Bern, Switzerland
    Br J Dermatol 158:691-7. 2008
    ..hidradenitis suppurativa) is a chronic inflammatory and cicatricial disorder that affects skin areas rich in apocrine glands and terminal hairs, such as perineum and axillae...
  61. ncbi Circumanal glands of the dog: a new classification and cell degeneration
    Y Atoji
    Laboratory of Veterinary Anatomy, Faculty of Agriculture, Gifu University, Yanagido, Japan
    Anat Rec 250:251-67. 1998
    ..In addition, we investigated the cell degeneration in lobules of the circumanal glands in relation to the apocrine glands.
  62. ncbi Experience using the thoracodorsal artery perforator flap in axillary hidradentitis suppurativa cases
    Carlos Laredo Ortiz
    Hospital General Universitario de Alicante, Spain
    Aesthetic Plast Surg 34:785-92. 2010
    Hidradenitis suppurativa is a chronic and recurrent inflammatory disease of the apocrine glands characterized by recurrent abscesses, draining sinus tracts, and scarring that can be located in the groin, axilla, perineal, and perianal ..
  63. ncbi Differential expression of mucin genes in mammary and extramammary Paget's disease
    S F Kuan
    Department of Pathology, University of Chicago Hospital, Chicago, Illinois 60637, USA
    Am J Surg Pathol 25:1469-77. 2001
    ..associated with underlying apocrine carcinoma had a phenotype (MUC1+MUC2-MUC5AC-) identical to that of normal apocrine glands. The skin appendage and Bartholin's glands from 20 normal-appearing vulvar skin samples and anal glands from ..
  64. ncbi [Practical management of hidradenitis suppurativa]
    J Pedraz
    Servicio de Dermatologia, Hospital Universitario de la Princesa, Madrid, Espana
    Actas Dermosifiliogr 99:101-10. 2008
    ..suppurativa is a chronic inflammatory disease that usually affects areas of the skin with a high density of apocrine glands (axillae, groin, perianal and perineal regions, submammary area, etc)...
  65. ncbi Development of a histomorphologic scale to quantify cutaneous scars after burns
    A J Singer
    Departments of Emergency Medicine, State University of New York, Stony Brook, NY, USA
    Acad Emerg Med 7:1083-8. 2000
    ..Cutaneous wound healing in adults invariably results in scarring; however, there are few scales to quantify the degree of such scarring. The authors developed a histomorphologic scale for quantifying scarring after cutaneous burn injury...
  66. ncbi "Hidradenitis suppurativa" is acne inversa! An appeal to (finally) abandon a misnomer
    Klaus Sellheyer
    Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Dermatol 44:535-40. 2005
    ..The term was historically coined based merely on the characteristic distribution of the apocrine glands and the anatomical coincidence with the disease process...
  67. ncbi ALA-PDT and blue light therapy for hidradenitis suppurativa
    Michael Gold
    Gold Skin Care Center, 2000 Richard Jones Road, Suite 220, Nashville, TN 37215, USA
    J Drugs Dermatol 3:S32-5. 2004
    Hidradenitis suppurativa (HS) is a chronic, often suppurative skin condition which affects primarily apocrine glands. A variety of therapies have been used to treat HS, often with unsatisfactory results...
  68. ncbi Hidradenitis suppurativa complicated by squamous cell carcinoma
    Constantinos Constantinou
    Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Am Surg 74:1177-81. 2008
    Hidradenitis suppurativa (HS) is a chronic inflammatory condition affecting the apocrine glands of the axilla, groin, and perianal region. Although it is a common condition, it is rarely associated with squamous cell carcinoma (SCC)...
  69. pmc Three fatal cases of squamous cell carcinoma arising in chronic perineal hidradenitis suppurativa
    Gael M Maclean
    Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Oxford, UK
    Ann R Coll Surg Engl 89:709-12. 2007
    Hidradenitis suppurativa (HS) is a chronic, inflammatory and suppurative disorder of skin bearing apocrine glands. The most severe complication is squamous cell carcinoma (SCC) and we here present three cases, all of which proved fatal, ..
  70. ncbi Ulnar-mammary syndrome with dysmorphic facies and mental retardation caused by a novel 1.28 Mb deletion encompassing the TBX3 gene
    Eva Klopocki
    Institute of Medical Genetics, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Hum Genet 14:1274-9. 2006
    ..characterized by hypoplasia or aplasia of upper limbs on the ulnar side, mammary glands and nipples, and of apocrine glands in both sexes (MIM #181450)...
  71. ncbi Thresholds and chemosensory event-related potentials to malodors before, during, and after puberty: differences related to sex and age
    Anita Chopra
    Unilever Research and Development Port Sunlight, Quarry Road East, Bebington, Wirral, CH63 3JW, UK
    Neuroimage 40:1257-63. 2008
    ..The latency increase in male pubescents may be due to the production of sweat by the apocrine glands resulting in increased levels of 2M3M and androstadienone, resulting in adaptation...
  72. ncbi Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study
    Anabelle Brocard
    Department of Dermatology, INSERM U601, CHU Hotel Dieu, Nantes, France
    Dermatology 214:325-7. 2007
    Hidradenitis suppurativa (Verneuil's disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective.
  73. ncbi Congenital melanotic macules and Sebaceous Choristoma arising on the tongue of a newborn: epidermal choristoma?
    D Azorin
    Servicio de Anatomia Patologica, Hospital Infantil Universitario Nino Jesus, Madrid 28009, Spain
    J Cutan Pathol 32:251-3. 2005
    ..basal pigmentation, under which, sebaceous glands, abortive hair follicles and ductal structures mimicking apocrine glands were found...
  74. ncbi Phyllodes tumor of the vulva: Report of a rare case and review of the literature
    Abul Ala Syed Rifat Mannan
    Departments of Pathology, Al Jahra Hospital, Kuwait City, Kuwait
    Am J Dermatopathol 32:384-6. 2010
    ..is controversial as it is being debated whether such lesions evolve from ectopic breast tissue, cutaneous apocrine glands, and most recently, anogenital mammary-like gland...
  75. ncbi Expression, candidate gene, and population studies of the melanocortin 5 receptor
    N Hatta
    Department of Dermatology, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Invest Dermatol 116:564-70. 2001
    ..immunoreactivity in the epithelium and appendages, including the sebaceous gland, eccrine glands, and apocrine glands, as well as low level expression in the interfollciular epidermis...
  76. ncbi Hidradenitis suppurativa: a comprehensive review
    Ali Alikhan
    University of California Davis School of Medicine, Sacramento, California 95816, USA
    J Am Acad Dermatol 60:539-61; quiz 562-3. 2009
    ..is now considered a disease of follicular occlusion rather than an inflammatory or infectious process of the apocrine glands. Clinically, the disease often presents with tender subcutaneous nodules beginning around puberty...
  77. ncbi Hidradenitis suppurativa managed with adalimumab
    Paul S Yamauchi
    Dermatology Institute and Skin Care Center, Santa Monica, CA 90404, USA
    J Drugs Dermatol 8:181-3. 2009
    Hidradenitis suppurativa (HS), a chronic, inflammatory, relapsing disease of the apocrine glands in the skin, commonly occurs in women aged 20 to 40 years...
  78. ncbi Pleomorphic adenoma in the auricle
    Young Min Yim
    Department of Plastic Surgery, College of Medicine, Catholic University of Korea, Uijongbu, Korea
    J Craniofac Surg 20:951-2. 2009
    ..These findings suggested that this tumor originated from the apocrine glands. Only a few cases of PA in the auricle have been reported in the literature, 2 of which occurred in the ..
  79. ncbi [Verneuil's disease or perianal hydradenitis suppurativa]
    A Pelayo Salas
    Facoltà di Medicina Ospedale Universitario Arnau de Vilanova, Lleida, Servizio di Chirugia Generale, Universita degli Studi, Lleida, Spain
    Minerva Chir 57:517-20. 2002
    ..suppurative disease with a tendency to fistulization and sclerosis, developing on the subcutaneous tissue, on apocrine glands. The perianal location is the most frequent, and the elective therapy in such case is surgery...
  80. ncbi Clinicopathological study of Fox-Fordyce disease
    Pei Han Kao
    School of Medicine, National Taiwan University, Taipei, Taiwan
    J Dermatol 36:485-90. 2009
    ..FFD) is a rare skin disease manifesting as multiple pruritic follicular papules involving the skin-bearing apocrine glands. Reports of FFD in Asian people are scant...
  81. ncbi Oestrogen functions in skin and skin appendages
    M J Thornton
    Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
    Expert Opin Ther Targets 9:617-29. 2005
    ..In addition, they can also modulate skin appendages such as the hair follicle, the sebaceous gland and the apocrine glands. Oestrogens may also have important modulatory roles in events such as skin ageing, pigmentation, hair growth,..
  82. ncbi Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene
    P J Biggs
    Section of Molecular Carcinogenesis, Institute of Cancer Research, Haddow Laboratories, Belmont, Sutton, Surrey, UK
    Nat Genet 11:441-3. 1995
    ..glands (which secrete lipids that may serve as a permeability barrier, emollient or antimicrobial agent), apocrine glands (which secrete scents) and eccrine glands (which produce sweat for temperature control)...
  83. ncbi The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus
    K M Waltz
    Penn State Geisinger Health System, Department of Medicine/Section of Dermatology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Pediatr Dermatol 16:211-3. 1999
    ..development of skin, pluripotential cells give rise to keratinocytes, sebaceous glands, hair follicles, apocrine glands, and eccrine glands...
  84. pmc A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene
    Motoi Nakano
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    BMC Genet 10:42. 2009
    ..AO was defined here as a clinical condition of individuals with a deep anxiety regarding axillary odor and had undergone the removal of bilateral axillary apocrine glands.
  85. ncbi Treatment of mammary and extramammary Paget's skin disease with topical imiquimod
    Ewa Mirer
    Department of Dermatology, CHU Purpan, Toulouse, France
    J Dermatolog Treat 17:167-71. 2006
    Paget's disease is an uncommon epidermal cancer, affecting all skin regions wherever apocrine glands are present. It is divided into extramammary (EMPD) and mammary Paget's disease (MPD)...
  86. pmc Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands
    Nidal A Obaidat
    Department of Laboratory Medicine and Pathobiology, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Clin Pathol 60:145-59. 2007
    ..In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been described: the apoeccrine and the mammary-like glands of the ..
  87. ncbi Eyelid multiple cysts of the apocrine gland of Moll in Persian cats
    Chiara Giudice
    Section of Veterinary Pathology, Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Via Celoria 10, 20133 Milan, Italy
    J Feline Med Surg 11:487-91. 2009
    Feline eyelid hidrocystoma is a rarely reported disease of the apocrine glands of Moll that has been variably interpreted as proliferative/neoplastic lesion or retention cyst...
  88. pmc The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia
    Jana Karbanova
    Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    J Histochem Cytochem 56:977-93. 2008
    ..In sweat glands including the gland of Moll, 80B258 immunoreactivity was found in the secretory (eccrine and apocrine glands) and duct (eccrine glands) portion...
  89. ncbi Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method
    Y Inoue
    Department of Plastic and Reconstructive Surgery, Toyoake, Japan
    J Plast Reconstr Aesthet Surg 63:1369-74. 2010
    Axillary osmidrosis (AO) is caused by apocrine glands secretions that are converted to odouriferous compounds by bacteria. A potential link between AO and wet earwax type has been implicated by phenotype-based analysis...
  90. ncbi Analysis of tissue- and hormone-specific regulation of the human prolactin-inducible protein/gross cystic disease fluid protein-15 gene in transgenic mice
    Y Myal
    Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Mol Endocrinol 21:217-23. 1998
    ..However, it is expressed in several normal human apocrine glands such as the lacrimal and salivary glands...
  91. ncbi Ultrasonography of the medial iliac lymph nodes in the dog
    Francisco J Llabres-Diaz
    Centre for Small Animal Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Vet Radiol Ultrasound 45:156-65. 2004
    Sixty-one medial iliac lymph nodes of 38 different dogs (eight with adenocarcinoma of the apocrine glands of the anal sac, 13 with multicentric lymphoma, six with multicentric lymphoma but in clinical remission, and 11 control dogs) were ..
  92. ncbi [Pathological study of radial sclerosing lesions]
    Xiao Li Zhang
    Shanxi Medical University, Taiyuan, China
    Zhonghua Bing Li Xue Za Zhi 39:10-3. 2010
    ..To investigate the pathological diagnostic features and the differential diagnosis of radial sclerosing lesions of the breast...
  93. ncbi Extra-mammary Paget's disease of the scrotum and penis: a case report
    Y M Chang
    Department of Plastic Surgery, Tri Service General Hospital, National Defence Medical Centre, Taipei, Taiwan, Republic of China
    Acta Chir Belg 109:808-10. 2009
    ..It is an intra-epithelial adenocarcinoma that involves the area rich in apocrine glands. The most common affected lesions are the vulva and perianal region, followed by the axillae and ..
  94. ncbi Mucinous hidradenoma: a report of three cases
    Seng Geok Nicholas Goh
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    J Cutan Pathol 34:497-502. 2007
    ..eyelid nodule and histology showed a mucinous apocrine hidradenoma with a proliferation of mucinous cells and apocrine glands. Case 2, from the shoulder of a 40-year-old man, was a 2...
  95. ncbi Extramammary Paget's disease--a proliferation of adnexal origin?
    S Regauer
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Histopathology 48:723-9. 2006
    ..Cytokeratin (CK) 15 and CK19 are considered markers for follicular stem cells located in the hair follicle bulge region...
  96. ncbi A refined surgical treatment modality for bromhidrosis: double w incision approach with tumescent technique
    Hang Li
    Department of Dermatology, First Hospital, Peking University, Beijing, China
    Dermatol Surg 35:1258-62. 2009
    ..Axillary bromhidrosis has a strong negative effect on one's social life. A high success rate and few complications are criteria for an ideal treatment method...
  97. ncbi Squamous cell carcinoma of the anal sac in five dogs
    D G Esplin
    Animal Reference Pathology Division, ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    Vet Pathol 40:332-4. 2003
    ..Whereas perianal adenomas occur often, adenocarcinomas of the apocrine glands of the anal sac occur less frequently...
  98. ncbi Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16
    Hiroaki Tomita
    Department of Human Genetics, Nagasaki University School of Medicine, Nagasaki, Japan
    Lancet 359:2000-2. 2002
    ..This trait is attributed to secretory products of the ceruminous apocrine glands, and frequencies of phenotypes vary between ethnic groups...
  99. pmc Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope
    Ulrike Samulowitz
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    Am J Pathol 160:1669-81. 2002
    ..stained the epithelium of the epidermis as well as epithelial and myoepithelial cells of the eccrine and apocrine glands in the skin...
  100. ncbi Oestrogen receptor evaluation in Pomeranian dogs with hair cycle arrest (alopecia X) on melatonin supplementation
    Linda A Frank
    Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, Tennessee 37996 4544, USA
    Vet Dermatol 17:252-8. 2006
    ..There was no oestrogen receptor-alpha staining of nuclei within the epidermis, apocrine glands or dermal fibroblasts. Large anagen hair bulbs had minimal to no oestrogen receptor staining...
  101. ncbi Fibroepithelial hamartoma in a domestic pig
    W Sipos
    University of Veterinary Medicine Vienna, Austria
    Vet Pathol 44:411-3. 2007
    ..In addition, some proliferating small blood vessels as well as focally gathered dilated apocrine glands were evident. Given morphologic and clinical features, the diagnosis of a hamartoma seemed to be justified.

Research Grants1

  1. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2002
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..