Summary: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.

Top Publications

  1. ncbi The endothelium: physiological functions and role in microcirculatory failure during severe sepsis
    H Ait-Oufella
    INSERM U970, PAris Research Cardiovascular Center, Paris, France
    Intensive Care Med 36:1286-98. 2010
  2. pmc MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro
    Yun Fang
    Institute for Medicine and Engineering, Center for Bioinformatics, and Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:13450-5. 2010
  3. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
  4. pmc Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 19:2282-7. 2008
  5. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
  6. ncbi The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    R F Furchgott
    Nature 288:373-6. 1980
  7. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
  8. ncbi Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation
    James H Finigan
    Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 280:17286-93. 2005
  9. pmc Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure
    Ananthakrishnan Sankaranarayanan
    Department of Pharmacology, University of California, Davis, California 95616, USA
    Mol Pharmacol 75:281-95. 2009
  10. ncbi Circulating endothelial cells in patients with septic shock
    M Mutunga
    Department of Anaesthesia and Intensive Care Medicine, Newcastle-upon-Tyne National Health Service Trust, Newcastle-upon-Tyne, United Kingdom
    Am J Respir Crit Care Med 163:195-200. 2001

Detail Information

Publications324 found, 100 shown here

  1. ncbi The endothelium: physiological functions and role in microcirculatory failure during severe sepsis
    H Ait-Oufella
    INSERM U970, PAris Research Cardiovascular Center, Paris, France
    Intensive Care Med 36:1286-98. 2010
    The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of ..
  2. pmc MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro
    Yun Fang
    Institute for Medicine and Engineering, Center for Bioinformatics, and Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:13450-5. 2010
    ..Comparative expression studies of endothelium located in athero-susceptible aortic arch and athero-protected descending thoracic aorta identified ..
  3. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
    ..Therapeutic co-transplantation of inductive VEGFR2(+)Id1(+)Wnt2(+)HGF(+) LSECs with hepatocytes provides an effective strategy to achieve durable liver regeneration...
  4. pmc Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 19:2282-7. 2008
    ..Collectively, our results demonstrate that EndMT contributes to the accumulation of activated fibroblasts and myofibroblasts in kidney fibrosis and suggest that targeting EndMT might have therapeutic potential...
  5. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
    Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells...
  6. ncbi The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    R F Furchgott
    Nature 288:373-6. 1980
    ..We propose that this may be one of the principal mechanisms for ACh-induced vasodilation in vivo. Preliminary reports on some aspects of the work have been reported elsewhere...
  7. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
    ..this organelle impaired nitric oxide and calcium signaling in the cardiovascular system, causing aberrations in endothelium-dependent relaxation, contractility, and maintenance of myogenic tone...
  8. ncbi Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation
    James H Finigan
    Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 280:17286-93. 2005
    ..These data suggest that novel EPCR ligation and S1P1 transactivation results in EC cytoskeletal rearrangement and barrier protection, components potentially critical to the improved survival of APC-treated patients with severe sepsis...
  9. pmc Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure
    Ananthakrishnan Sankaranarayanan
    Department of Pharmacology, University of California, Davis, California 95616, USA
    Mol Pharmacol 75:281-95. 2009
    ..1 channels in murine endothelial cells, and the more "drug-like" SKA-31 (half-life of 12 h) potentiated endothelium-derived hyperpolarizing factor-mediated dilations of carotid arteries from KCa3.1(+/+) mice but not from KCa3...
  10. ncbi Circulating endothelial cells in patients with septic shock
    M Mutunga
    Department of Anaesthesia and Intensive Care Medicine, Newcastle-upon-Tyne National Health Service Trust, Newcastle-upon-Tyne, United Kingdom
    Am J Respir Crit Care Med 163:195-200. 2001
    The vascular endothelium has a central role in the control of microvascular tone, and it has been proposed that vascular endothelial damage occurs in septic shock, producing multiorgan failure...
  11. pmc Human glomerular endothelium: interplay among glucose, free fatty acids, angiotensin II, and oxidative stress
    Edgar A Jaimes
    Renal Division, University of Alabama at Birmingham, AL 35294, USA
    Am J Physiol Renal Physiol 298:F125-32. 2010
    ..These novel studies are the first in human GEC that characterize the differential role of FFA, hyperglycemia, and ANG II on the genesis of ROS, COX-2, and PGs and their interplay in the early stages of hyperglcyemia...
  12. pmc Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium
    Daniel H Paris
    Mahidol Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 6:e1466. 2012
    ..tsutsugamushi from the initial eschar site. This newly described cellular tropism for O. tsutsugamushi may influence its interaction with local host immune responses...
  13. ncbi Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Kidney Int 64:1648-52. 2003
    ..We tested the hypothesis that darbepoetin alfa [i.e., a recombinant analogue of the cytokine erythropoietin (EPO)] stimulates proliferation and differentiation of EPCs...
  14. pmc Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
    Philip M Bauer
    Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 102:204-9. 2005
    ..First, increasing levels of Cav-1 do not increase caveolae number in the endothelium in vivo...
  15. ncbi Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
    Mattias Bjarnegard
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 131:1847-57. 2004
    ..The endothelium-restricted Pdgfb knockout mutants also developed organ defects including cardiac, placental and renal ..
  16. pmc Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant
    Lloyd Hutchinson
    Department of Pathology, UMass Memorial Health Care, Worcester, MA, USA
    Stem Cells Dev 20:11-7. 2011
    ..These findings demonstrate that BMDCs can generate cancer-associated fibroblasts as well as contribute directly to epithelial cells in cancer of the esophagus...
  17. ncbi Pulmonary endothelium in acute lung injury: from basic science to the critically ill
    S E Orfanos
    Department of Critical Care and Pulmonary Medicine, M Simou Laboratory, Medical School, University of Athens, Evangelismos Hospital, 45 47 Ipsilandou St, 10675, Athens, Greece
    Intensive Care Med 30:1702-14. 2004
    Pulmonary endothelium is an active organ possessing numerous physiological, immunological, and metabolic functions...
  18. ncbi P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta
    Leon M Tai
    Department of Life Sciences, The Open University, Walton Hall, Milton Keynes, UK
    J Cereb Blood Flow Metab 29:1079-83. 2009
    ..Our in vitro data suggest that P-gp and BCRP might act to prevent the blood-borne Abeta 1-40 from entering the brain...
  19. ncbi Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium
    Dorothee Faille
    Department of Pathology, University of Sydney, 92 94 Parramatta Rd, Camperdown, NSW 2042, Australia
    FASEB J 23:3449-58. 2009
    ..PMPs thereby provide a novel target for antagonizing interactions between vascular cells that promote microvascular sludging and blood brain barrier alteration during CM...
  20. pmc PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice
    Takeshi Kanda
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 119:110-24. 2009
    ..defined as abnormal vasoreactivity, is a common early finding in individuals with type 2 diabetes, the endothelium has not been known to regulate metabolism...
  21. pmc Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow
    Chih Wen Ni
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
    Blood 116:e66-73. 2010
    ..for protein, including LMO4, which showed higher expression in mouse aortic arch and in human coronary endothelium in an asymmetric pattern...
  22. ncbi Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis
    Guillaume Grenier
    Sprott Centre for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Stem Cells 25:3101-10. 2007
    ..This finding is of particular interest since it could bring new insight in cancer angiogenesis and collateral blood vessels developed following ischemia. Disclosure of potential conflicts of interest is found at the end of this article...
  23. ncbi Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium
    Salomón Matías-Román
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Blood 105:3956-64. 2005
    ..In addition, monocyte transmigration through tumor necrosis factor-alpha (TNF-alpha)-activated endothelium is also inhibited by anti-MT1-MMP mAb...
  24. pmc Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration
    Sarah J Heasman
    Randall Division of Cell and Molecular Biophysics, King s College London, London, England, UK
    J Cell Biol 190:553-63. 2010
    ..Our data indicate that RhoA activity is dynamically regulated at the front and back of T cells to coordinate TEM...
  25. ncbi Occludin as a possible determinant of tight junction permeability in endothelial cells
    T Hirase
    Eisai London Research Laboratories Ltd, University College London, UK
    J Cell Sci 110:1603-13. 1997
    ..Our data indicate that regulation of occludin expression may be a crucial determinant of the tight junction permeability properties of endothelial cells in different tissues...
  26. pmc Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
    D D Wagner
    J Cell Biol 95:355-60. 1982
    ..These data suggest that the Weibel-Palade bodies of endothelial cells are storage and/or processing organelles for von Willebrand protein...
  27. ncbi The effect of vitamin D replacement on markers of vascular health in stroke patients - a randomised controlled trial
    M D Witham
    Ageing and Health, Centre for Cardiovascular and Lung Biology, Division of Medicine, University of Dundee, Dundee DD1 9SY, UK
    Nutr Metab Cardiovasc Dis 22:864-70. 2012
    ..We tested whether vitamin D supplementation could reduce blood pressure and improve markers of vascular health in patients who had previously suffered a stroke...
  28. pmc Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria
    Patricia A Reis
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    PLoS Pathog 8:e1003099. 2012
    ..a decrease in functional capillary density and an increase in rolling and adhesion of leukocytes to inflamed endothelium that were reversed by treatment with lovastatin...
  29. ncbi Expression of cell adhesion molecules and the appearance of adherent leukocytes on the left atrial endothelium with atrial fibrillation: rabbit experimental model
    N Kamiyama
    Division of Cardiology Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Jpn Circ J 62:837-43. 1998
    To assess the expression of cell adhesion molecules and the appearance of leukocytes adhering to the left atrial endothelium with atrial fibrillation (AF), 10 Japanese white rabbits were anesthetized and 3 pacing leads were placed in the ..
  30. ncbi Inducible secretion of large, biologically potent von Willebrand factor multimers
    L A Sporn
    Cell 46:185-90. 1986
    ..Endothelial cells therefore concentrate a special subclass of very large and biologically potent vWf multimers in Weibel-Palade bodies, presumably available for release in response to vascular injury...
  31. ncbi A synthetic peptide vector system for optimal gene delivery to corneal endothelium
    Louise Collins
    Department of Clinical Sciences, Institute of Liver Studies, Guy s King s and St Thomas School of Medicine, King s College Hospital, Bessemer Road, London SE5 9PJ, UK
    J Gene Med 6:185-94. 2004
    ..Efficient and non-toxic gene delivery, preferably with non-viral DNA vectors readily transferable to clinical practice, is generally regarded as a major limitation for gene therapy...
  32. pmc Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries
    Javier Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Spain
    Br J Pharmacol 139:854-62. 2003
    1 We have evaluated the participation of endothelium-derived hyperpolarizing factor (EDHF) in the endothelium-dependent relaxation of isolated human penile resistance arteries (HPRA) and human corpus cavernosum (HCC) strips...
  33. pmc Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy
    Yong Hong Chen
    Department of Internal Medicine, Iowa City, Iowa, USA
    Nat Med 15:1215-8. 2009
    ..Peripheral injection of the epitope-modified AAVs expressing the enzymes lacking in LSD mice reconstituted enzyme activity throughout the brain and improved disease phenotypes in two distinct disease models...
  34. ncbi Endothelium-coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection
    Tong Ding
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen Zhongshan University, Guangzhou, China
    Cancer 117:4878-89. 2011
    Distinct morphologic features of microvascular endothelium exist in tumor tissues. The objective of this study was to investigate the prognostic value of endothelium-coated tumor clusters (ECTCs) in hepatocellular carcinoma (HCC).
  35. pmc Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation
    Axel M Küchler
    Laboratory for Immunology and Immunopathology, Division of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Am J Pathol 173:1229-42. 2008
    ..of vascular IL-33, a response consistent with both its rapid down-regulation in wound healing and loss in tumor endothelium. In conclusion, we speculate that the proposed transcriptional repressor function of IL-33 may be involved in ..
  36. ncbi In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium
    Raffaella Rossin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 49:103-11. 2008
    ..intercellular adhesion molecule 1 (ICAM-1) hold promise as a mean of delivering therapeutics to the pulmonary endothelium in patients with acute and chronic respiratory diseases...
  37. pmc Role of protein tyrosine phosphatase SHP2 in barrier function of pulmonary endothelium
    K L Grinnell
    Vascular Research Laboratory, Providence VA Medical Center, 830 Chalkstone Ave, Providence, RI 02908, USA
    Am J Physiol Lung Cell Mol Physiol 298:L361-70. 2010
  38. pmc Non-nuclear estrogen receptor signaling in the endothelium
    Qian Wu
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 286:14737-43. 2011
    ..evidence continues to accumulate that they mediate non-nuclear processes in numerous cell types, including the endothelium, in which they activate endothelial NO synthase...
  39. ncbi Valproic acid blocks adhesion of renal cell carcinoma cells to endothelium and extracellular matrix
    Jon Jones
    Department of Urology and Pediatric Urology, Goethe University Hospital, Frankfurt am Main, Germany
    J Cell Mol Med 13:2342-52. 2009
    ..VPA significantly and dose-dependently prevented tumour cell attachment to endothelium or matrix proteins, accompanied by elevated histones H3 and H4 acetylation...
  40. pmc Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice
    Takahisa Murata
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06511
    J Exp Med 204:2373-82. 2007
    ..These results provide clear physiological evidence supporting the important role of cell type-specific Cav-1 expression governing multiple phenotypes in the vasculature, heart, and lung...
  41. ncbi Tumor cytotoxicity by endothelial cells. Impairment of the mitochondrial system for glutathione uptake in mouse B16 melanoma cells that survive after in vitro interaction with the hepatic sinusoidal endothelium
    Angel L Ortega
    Departamento de Fisiologia, Universidad de Valencia, Spain
    J Biol Chem 278:13888-97. 2003
    ..GSH homeostasis was investigated in LD B16M cells that survive after adhesion to the hepatic sinusoidal endothelium (HSE)...
  42. pmc Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury
    Loc Duyen D Pham
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Glia 60:875-81. 2012
    ..In gray matter, a neurovascular niche promotes cortical recovery after brain injury. Our study suggests that an analogous oligovascular niche may mediate recovery in white matter...
  43. ncbi Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk
    Katrien Lemmens
    Department of Physiology, University of Antwerp, Antwerp 2020, Belgium
    J Biol Chem 281:19469-77. 2006
    ..extent ErbB2, the favored co-factor of ErbB4 for heterodimerization, participates in the cardiac effects of endothelium-derived NRG-1...
  44. ncbi Stop the flow: a paradigm for cell signaling mediated by reactive oxygen species in the pulmonary endothelium
    Elizabeth A Browning
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 74:403-24. 2012
    The lung endothelium is exposed to mechanical stimuli through shear stress arising from blood flow and responds to altered shear by activation of NADPH (NOX2) to generate reactive oxygen species (ROS)...
  45. ncbi Dkk-3 expression in the tumor endothelium: a novel prognostic marker of pancreatic adenocarcinomas
    Dominic Fong
    Department of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
    Cancer Sci 100:1414-20. 2009
    ..Overexpression of Dkk-3 enhanced endothelial cell growth inhibition to chemotherapeutic drugs. Therefore, we suggest that Dkk-3 high microvessel density may help to select patients who may benefit from chemotherapy...
  46. pmc Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes
    Lu Tie
    VA Vascular Surgery Research, Dept of Surgery, Univ of Pittsburgh School of Medicine, 2W109 151L U VAPHS, University Dr, Pittsburgh, PA 15240, USA
    Am J Physiol Endocrinol Metab 296:E1423-9. 2009
    ..Blood glucose levels were significantly increased in both male endothelium-specific GTPCH I transgenic mice (Tg-GCH; via a tie-2 promoter) and wild-type (WT) littermates 5 days after STZ ..
  47. ncbi Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging
    Pal Pacher
    Inotek Corporation, Suite 419E, 100 Cummings Center, Beverly, MA 01915, USA
    Int J Mol Med 9:659-64. 2002
    ..Thus, PARP activation contributes to the pathogenesis of endothelial dysfunction associated with hypertension and aging, but not in the current experimental model of atherosclerosis...
  48. pmc CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium
    Alexander I Aspinall
    The Liver Unit, University of Calgary Health Sciences Center, Calgary, Alberta, Canada
    Hepatology 51:2030-9. 2010
    ..Adhesion and transmigration across HSECs under flow was also dependent on vascular adhesion protein-1 (VAP-1) on the HSECs...
  49. ncbi Minireview: rapid actions of sex steroids in the endothelium
    Renee W Y Chow
    Heart Research Institute, 7 Eliza Street, Newtown, Sydney, New South Wales 2042, Australia
    Endocrinology 151:2411-22. 2010
    The endothelium is a dynamic interface between the blood vessel and the circulating blood that plays a pivotal role in vascular homeostasis...
  50. pmc Mammalian stanniocalcin-1 activates mitochondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium
    David Sheikh-Hamad
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 298:F248-54. 2010
    ..Our data suggest that STC1 activates antioxidant pathways in endothelial cells and macrophages and displays cytoprotective and anti-inflammatory actions...
  51. pmc Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB
    Lara F Costa
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 107:285-92. 2006
    ..The molecular mechanisms involved in the modulation and recruitment of BM endothelium are largely unknown and may provide novel therapeutic targets for neoplastic diseases...
  52. pmc Update on the glomerular filtration barrier
    George Jarad
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Nephrol Hypertens 18:226-32. 2009
    ..The glomerular capillary wall consists of three distinct but closely interacting layers: the fenestrated endothelium, with its glycocalyx; the podocytes, with their interdigitated foot processes and slit diaphragms; and the ..
  53. ncbi Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    T N Mayadas
    New England Medical Center, Department of Medicine, Boston, Massachusetts
    Cell 74:541-54. 1993
    ..These mutant mice should prove useful in deciphering the contributions of P selectin in various inflammatory responses as well as in platelet functions...
  54. pmc Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo
    Reema Jasuja
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 116:4665-74. 2010
    ..These results indicate that, although both platelets and endothelial cells secrete PDI after laser-induced injury, PDI from endothelial cells is required for fibrin generation in vivo...
  55. ncbi Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice
    E Gustafsson
    Department of Experimental Pathology, Lund University, Lund, Sweden
    J Cell Sci 114:671-6. 2001
    ..These results show that the tie-1-Cre transgenic strain can efficiently direct deletion of floxed genes in endothelial cells in vivo...
  56. ncbi Mechanical interactions among cytoskeletal filaments
    N Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02115, USA
    Hypertension 32:162-5. 1998
    ..We conclude that higher order mechanical interactions of CSK filaments are important in determining the mechanical properties of the cell...
  57. ncbi Pathogenic mechanisms in rheumatic carditis: focus on valvular endothelium
    S Roberts
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Infect Dis 183:507-11. 2001
    ..At the valve surface, CD4(+) and CD8(+) T lymphocytes were adherent to valve endothelium and penetrated through the subendothelial layer...
  58. ncbi Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines
    Peter C E Burdon
    Leukocyte Biology Section, NHLI Division, Faculty of Medicine, Imperial College, South Kensington, London, UK
    Br J Haematol 142:100-8. 2008
    ..neutrophil migration from the haematopoietic compartment of the bone marrow across the bone marrow sinusoidal endothelium via a transcellular route...
  59. pmc Adriamycin alters glomerular endothelium to induce proteinuria
    Marie Jeansson
    The Renal Center Wallenberg Laboratory, Institute of Internal Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Am Soc Nephrol 20:114-22. 2009
    ..These data suggest that the glomerular endothelium may play a role in the pathogenesis of proteinuric renal diseases.
  60. pmc Nf1 has an essential role in endothelial cells
    Aaron D Gitler
    Department of Medicine, Cardiology Division, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 33:75-9. 2003
    ..These results establish a new and essential role for Nf1 in endothelial cells and confirm the requirement for neurofibromin in the neural crest...
  61. ncbi Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration
    Yasmin Issa
    Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:99-112. 2009
    ..We observed that L1CAM expression was selectively enhanced on endothelium associated with pancreatic adenocarcinoma in situ and on cultured pancreatic tumor-derived endothelial cells in ..
  62. ncbi The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development
    P E Young
    Department of Immunology, Genentech, Inc, South San Francisco, CA 94080
    Blood 85:96-105. 1995
    ..We have recently shown that murine CD34 (mCD34) is expressed on the vascular endothelium in all organs and tissues of the adult mouse as well as on a small percentage of presumably hematopoietic stem ..
  63. ncbi Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium
    S Christian
    Department of Oncology Research and the Genomics Group, Boehringer Ingelheim Pharma KG, 88397 Biberach an der Riss, Germany
    J Biol Chem 276:7408-14. 2001
    ..antibody FB5, is a highly restricted 165-kDa cell surface glycoprotein expressed by tumor blood vessel endothelium in a broad range of human cancers but not detected in blood vessels or other cell types in many normal tissues...
  64. ncbi Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
    C B Brown
    Department of Pharmacology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232 6600, USA
    Science 283:2080-2. 1999
    ..These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-beta signaling...
  65. pmc Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    T Makinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, FIN 00014 Helsinki, Finland
    EMBO J 20:4762-73. 2001
    ..and cultured stable lineages of blood vascular and lymphatic endothelial cells from human primary microvascular endothelium by using antibodies against the extracellular domain of VEGFR-3...
  66. pmc Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus
    G O'Driscoll
    Department of Cardiology and Medicine, Royal Perth Hospital, Australia
    J Clin Invest 100:678-84. 1997
    ..blood flow measurement using strain gauge plethysmography during intraarterial infusion of incremental doses of endothelium-dependent (acetylcholine [ACh]) and endothelium-independent (sodium nitroprusside [SNP]) vasodilators...
  67. ncbi Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines
    Revital Shamri
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 6:497-506. 2005
    ..In vitro flow chamber models showed that endothelium-presented but not soluble chemokines triggered instantaneous extension of bent LFA-1 in the absence of LFA-1 ..
  68. ncbi A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stress
    Gennady G Yegutkin
    MediCity Research Laboratory, Tykistokatu 6A, 20520 Turku, Finland
    Eur J Immunol 34:2276-85. 2004
    ..Moreover, the inhibitory peptide diminishes leukocyte interactions with endothelial cells under conditions of shear, and thus it may be useful to treat inflammatory conditions...
  69. ncbi Fibronectin binding proteins contribute to the adherence of Staphylococcus aureus to intact endothelium in vivo
    Sylvain Kerdudou
    Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Homburg Saar, Germany
    Thromb Haemost 96:183-9. 2006
    ..these results demonstrate that staphylococcal FnBPs significantly contribute to primary interaction with intact endothelium under physiologic conditions...
  70. pmc Interactions of human prostatic epithelial cells with bone marrow endothelium: binding and invasion
    L J Scott
    CRC Experimental Haematology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK
    Br J Cancer 84:1417-23. 2001
    ..We have developed an in vitro system to study the binding of prostate epithelial cells to bone marrow endothelium (BME) and stroma (BMS)...
  71. ncbi Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers
    Tommaso Gori
    Division of Cardiology, Department of Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Am J Cardiol 91:1392-4. 2003
  72. ncbi Erythropoietin and the endothelium - a promising link?
    D Fliser
    Saarland University Medical Centre, Homburg, Germany
    Eur J Clin Invest 38:457-61. 2008
    ..This mini review summarizes the present knowledge on protective vascular effects of EPO and discusses the potential underlying mechanisms...
  73. pmc Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma
    Angel Carlos Roman
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain
    J Biol Chem 284:25135-48. 2009
    ..Thus, AhR modulates angiogenesis through a mechanism requiring VEGF activation in the endothelium and TGFbeta inactivation in the stroma...
  74. pmc TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
    T Oshima
    Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, Louisiana, USA
    BMC Gastroenterol 1:5. 2001
    ..It has been suggested that both reactive oxygen and nitrogen metabolites participate in regulating adhesion molecule expression in response to TNF-alpha...
  75. ncbi Coronary oxygen persufflation for heart preservation in pigs: analyses of endothelium and myocytes
    Ferdinand Kuhn-Regnier
    Department of Cardiothoracic Surgery, University of Cologne, Cologne, Germany
    Transplantation 77:28-35. 2004
    ..The aim of the present study was to assess the structural, metabolic, and functional myocardial and endothelial integrity after COP in mature pig hearts...
  76. ncbi PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers
    Masashi Kimura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertension 41:1106-10. 2003
    ..We evaluated the forearm blood flow (FBF) responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and to sodium nitroprusside (SNP), an endothelium-independent vasodilator, before and ..
  77. ncbi Endothelial and myogenic differentiation of hematopoietic progenitor cells in inflammatory myopathies
    David Hollemann
    Department of Blood Group Serology and Transfusion Medicine, Institute of Neurology, Medical University Vienna, Austria
    J Neuropathol Exp Neurol 67:711-9. 2008
    ..Our findings suggest that circulating HPCs colonize skeletal muscle in inflammatory conditions and provide evidence for in situ myoendothelial differentiation of some of these cells...
  78. ncbi How the endothelium and its bone marrow-derived progenitors influence development of disease
    Tihomir Stefanec
    Brown University, Providence, RI, USA
    Med Hypotheses 62:247-51. 2004
  79. pmc Development of the endothelium: an emphasis on heterogeneity
    Laura A Dyer
    McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    Semin Thromb Hemost 36:227-35. 2010
    The endothelium is composed of specialized epithelial cells that line the vasculature, the lymph vessels, and the heart...
  80. ncbi Scanning electron microscopy examination of endothelium morphology in human carotid plaques
    Terenzio Congiu
    Department of Human Morphology, University of Insubria, Varese, Italy
    Micron 41:532-6. 2010
    ..In the present study, by using SEM analysis, the morphological features of dysfunctional endothelium in human carotid plaques were extensively documented at the ultrastructural level...
  81. ncbi The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis
    Gang Ming Zou
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Cell Physiol 219:209-18. 2009
    ..We explored the role of the Ape-1/Ref-1 redox domain in the maintenance of tumor-associated endothelium, and of endothelial progenitor cells (EPCs), which contribute to tumor angiogenesis...
  82. ncbi Xenograft rejection: IgG1, complement and NK cells team up to activate and destroy the endothelium
    Robert Rieben
    Department of Clinical Research, University of Bern, Murtenstrasse 31, PO Box 33, CH 3010 Bern, Switzerland
    Trends Immunol 26:2-5. 2005
  83. pmc Potential role of nuclear factor κB in diabetic cardiomyopathy
    O Lorenzo
    Vascular Pathology Laboratory, Instituto de Investigaciones Sanitarias IIS Fundación Jiménez Díaz, Av Reyes Catolicos 2, Madrid 28040, Spain
    Mediators Inflamm 2011:652097. 2011
  84. ncbi Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression
    Estelle Oberlin
    INSERM, U602, Villejuif, France
    Int J Dev Biol 54:1165-73. 2010
    ..Altogether our studies strongly suggest that at least a part of both the human and the murine hematopoietic systems arise from an endothelium-like ancestor.
  85. ncbi Cultivation in human serum reduces adipose tissue-derived mesenchymal stromal cell adhesion to laminin and endothelium and reduces capillary entrapment
    Lena Dreher
    German Red Cross Blood Service of Baden Württemberg Hessen, Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology, Heidelberg University, Mannheim, Germany
    Stem Cells Dev 22:791-803. 2013
    ..Appropriate injury models and further molecular analyses are required to provide mechanistic insight into the differential effects of HS versus FBS on ASC cultures...
  86. ncbi Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5
    Paolo Macor
    University of Trieste, Trieste, Italy
    Arthritis Rheum 64:2559-67. 2012
  87. ncbi Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus
    Dae Won Chung
    Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151 742, South Korea
    Cell Mol Neurobiol 30:531-41. 2010
    ..COX-2 immunoreactivity was significantly increased in the endothelium of blood vessels in the hippocampus 6 h after LPS treatment, judging from double immunofluorescence study with ..
  88. pmc Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes
    Akira Mima
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Diabetes 61:2967-79. 2012
    ..PKCβ isoform activation induced by diabetes decreased GLP-1R expression and protective action on the renal endothelium by increasing its degradation via ubiquitination and enhancing phospho-c-Raf(Ser338) and Ang II activation of ..
  89. ncbi Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats
    Bum Ju Ahn
    NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 387:321-5. 2009
  90. ncbi Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia
    Carlos J Veas
    Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, P O Box 237, Concepcion, Chile
    J Matern Fetal Neonatal Med 24:1371-7. 2011
    ..To evaluate the association between endothelial activation markers in the maternal circulation with nitric oxide (NO) synthesis in human umbilical endothelial cells...
  91. ncbi Advanced glycation end products induce moesin phosphorylation in murine brain endothelium
    Qiaoqin Li
    Department of Pathophysiology, Key Lab for Shock and Microcirculation Research, Southern Medical University, 1023 Shatai Road, Tonghe, Guangzhou 510515, PR China
    Brain Res 1373:1-10. 2011
    ..These results demonstrate that AGEs cause the phosphorylation of moesin in murine brain microvascular endothelial cells, with p38 and ROCK being involved in this process...
  92. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone...
  93. ncbi Intensive insulin treatment attenuates burn-initiated acute lung injury in rats: role of the protective endothelium
    Wan Fu Zhang
    Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    J Burn Care Res 32:e51-8. 2011
    ..insulin treatment would attenuate burn-induced acute lung injury by protecting the pulmonary microvascular endothelium. The rat model of burn injury was achieved by exposure to 92°C water for 18 seconds...
  94. pmc Endothelium-induced proliferation and electrophysiological differentiation of human embryonic stem cell-derived neuronal precursors
    Bin Lai
    Buck Institute for Age Research, Novato, CA 94945 0638, USA
    Stem Cells Dev 17:565-72. 2008
    ..These findings indicate that ECs can regulate the proliferation and electrophysiological neuronal differentiation of human NPCs...
  95. pmc TRPing on the lung endothelium: calcium channels that regulate barrier function
    Donna L Cioffi
    Center for Lung Biology, University of South Alabama, Mobile, Alabama 36688, USA
    Antioxid Redox Signal 11:765-76. 2009
    ..Thus, phenotypic heterogeneity in ion channel expression and function exists within the lung endothelium, along the arterial-capillary-venous axis, and is coupled to discrete control of endothelial barrier function.
  96. ncbi Hypoglycemic pharmacological treatment of type 2 diabetes: targeting the endothelium
    David Nathanson
    Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital, Sodersjukhuset, Ringvägen 52, SE 118 83 Stockholm, Sweden
    Mol Cell Endocrinol 297:112-26. 2009
    ..Also, insulin resistance is not confined to skeletal muscle, adipose tissue and the liver, but also to the endothelium. Insulin resistance and endothelial dysfunction co-exist, where chronic inflammation may be a crucial factor...
  97. ncbi Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule
    Xiaoqiang Yao
    Department of Medicine, Section of Nephrology, Yale University School of Medicine, West Haven VA Medical Center, 333 Cedar Street, New Haven, CT 06520 8029, USA
    J Am Soc Nephrol 13:2831-9. 2002
    ..Furthermore, its presence in endothelial and vascular smooth muscle cells supports the notion that it also regulates vascular tone...
  98. ncbi Response of mesenchymal stem cells to the biomechanical environment of the endothelium on a flexible tubular silicone substrate
    Eoin D O'Cearbhaill
    National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland
    Biomaterials 29:1610-9. 2008
    ..However, gene expression results show the cells exhibit greater levels of SMC-associated markers alpha-smooth muscle actin and calponin (p<0.05)...
  99. pmc Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation
    Jin Qian
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Heart Circ Physiol 298:H112-8. 2010
    ..We conclude that the greater functional effects of PM eNOS are due to the increased amount of NO produced rather than effects derived from the local synthesis of NO...
  100. ncbi Effect of antibodies on endothelium
    X Zhang
    Department of Pathology, UCLA Immunogenetics Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Am J Transplant 9:2459-65. 2009
    Patients developing posttransplant antibodies against HLA and non-HLA antigens expressed by the endothelium of the graft undergo more frequent episodes of rejection and have decreased long-term graft survival...
  101. ncbi Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions
    Mira Lischper
    Institute of Biochemistry, Westfaelische Wilhelms Universitaet Muenster, Muenster, Germany
    Brain Res 1326:114-27. 2010
    ..Thus, in our model occludin cleavage is not an autoregulatory mechanism of microcapillary endothelium in barrier modulation under oxidative stress, but only occurs upon endothelial damage.

Research Grants79

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..and maintenance of these cell populations, (b) migration and establishment of intercellular contacts with the endothelium, and (c) sub-division of the existing endothelial tubes to allow rapid expansion of capillary surface area...
  2. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..To test these hypotheses, we propose to 1. measure endothelium-dependent and endothelium-independent dilation in isolated human coronary and adipose arterioles (from non-..
  3. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Ultrasound of brachial flow-mediated dilation will be used to evaluate changes in vascular endothelium function...
  4. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..Furthermore, we anticipate this research will lead to the development of a new drug that inhibits the enzyme's activity and blocks the change of LDL. ..
  5. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..b>Endothelium-dependent vasodilatation will be determined by videomicroscopy...
  6. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..of the vasculature, and ultimately edema or hemorrhagic disease result from altering barrier functions of the endothelium. Postmortem studies of DV-infected patients and the AG129 mouse model demonstrate that ECs in the liver, lung, ..
  7. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    Francis W Luscinskas; Fiscal Year: 2013
    ..The vascular endothelium plays an active and vital role in regulating inflammatory responses and in maintaining homeostasis of the ..
  9. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Title of grant: Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Ischemia-reperfusion (I/R) injury to vital organs and tissue can occur in a variety of clinical ..
  10. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Although abnormalities of the platelets, endothelium and adventitia contribute critically to the pathogenesis of PAH, excessive proliferation of pulmonary arterial ..
  11. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..At the same time, activation of RAS and XO in resistance arteries leads to impairment in endothelium- dependent vasodilation...
  12. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..with SCD TSP1 levels in the plasma of patients with SCD disrupt the vasodilator/vasoconstrictor balance in endothelium and smooth muscle by inhibition of NO signaling and increasing ROS and ETA levels;(2) to employ unique mutant ..
  13. Role of Endocytosis and Vesicular Trafficking in Podocyte Health and Filter Integ
    Puneet Garg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The functional kidney filter is likely created by the capillary endothelium, the glomerular basement membrane, and the "slit diaphragm" or specialized intercellular junction that lies between the ..
  14. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..that an inflammatory oxidative environment in the cardiovascular system can lead to pathologic changes in the endothelium and contribute to atherosclerosis...
  15. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..In both cases, unique chemokines (chemotactic cytokines) produced by the lymphatic endothelium play central roles in driving the respective transit of either immune cells or tumor cells...
  16. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
  17. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..We will use this technique to measure flow and artery responses to intra-arterial infusions of the endothelium-dependent vasodilator acetylcholine 10-6M, the microvascular endothelium-independent dilator adenosine, and the ..
  18. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..The vascular endothelium plays an important role in regulating blood flow, in inhibiting platelet aggregation and in the immune and ..
  19. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..tissues have been reported and transcripts of EPO and/or its receptor (EPOR) genes are found in brain, endothelium, hematopoietic stem cells, breast, ovary, testes, and other tissues...
  20. Mechanism of eNOS Uncoupling in the Renal Microvasculature
    YVES CLAUDE GORIN; Fiscal Year: 2013
    ..Our preliminary data show that in isolated glomeruli, where endothelium and mesangium are intact, eNOS generates ROS and lesser amount of NO upon stimulation with high glucose ..
  21. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2012
    ..The central hypothesis of this proposal is that S1P profoundly regulates the phenotype of vascular endothelium by temporally- and spatially-precise signaling of S1P1R and S1P2R...
  22. Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    HUA LINDA CAI; Fiscal Year: 2013
    ..this application is to examine a previously uncharacterized, critical signaling role of cardiac microvascular endothelium in mediating cardioprotection during ischemia reperfusion (I/R) injury of the heart...
  23. Regulation of the Endothelial Citrulline-Nitric Oxide Cycle
    Duane C Eichler; Fiscal Year: 2010
    ..The second aim is based on our work demonstrating that endothelium-specific upstream open reading frame of AS mRNA encodes a small protein, Argininosuccinate Synthase Regulatory ..
  24. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..To invade joints and other host tissue, the cells must adhere to the endothelium of blood vessels in target organs and penetrate through them. The unique motility and morphology of B...
  25. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    ..endothelial cell survival during lymphangiogenesis and subsequent tumor metastasis;that lymph node lymphatic endothelium promotes the homing, adhesion and extravasation of tumor cells by expressing key tumor cell chemoattractants ..
  26. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
    ..provided by applicant): Endothelin-1 (ET-1) is a 21 amino acid potent vasoconstrictor and product of vascular endothelium. ET-1 is also a tumor-secreted factor that has a central role in osteoblast activation and the osteosclerotic ..
  27. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    ..e., loss of endothelium-dependent relaxation) and cardiomyopathy (i.e., left ventricular dysfunction, hypertrophy and cardiac fibrosis)...
    Devendra K Agrawal; Fiscal Year: 2013
    ..b>Endothelium-dependent and -independent coronary vasodilatation will be measured by intracoronary administration of ..
  29. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..The goal of this study is to determine 1) if macrophages can successful deliver miR-126 to the vascular endothelium, 2) If delivery of miR-126 to the vessel wall protects the endothelium thereby decreasing atherosclerotic ..
  30. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Nitric oxide (NO) from endothelium nitric oxide synthase (eNOS) is important in maintaining normal cerebral blood flow...
  31. Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    Laurence E Cheng; Fiscal Year: 2013
    ..Preliminary data indicate that tissue mast cells extend projections into the vascular endothelium as a means to capture IgE and respond to allergen...
  32. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..Challenge Topic, 04-HL-103, "Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases"...
  33. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..This program will focus on the endothelium, which is generally believed to be the first vascular cell altered during both atherogenesis and impaired ..
  34. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..Challenge topic, 04- HL-103: Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  35. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    DESCRIPTION (provided by applicant): Endothelium forms a thin lining inside blood vessels that acts a barrier to control the response of the vasculature to inflammatory agonists...
  36. Pathogenic Mechanisms of PBEF in Ventilator Induced Lung Injury
    Joe G N Garcia; Fiscal Year: 2012
    ..Specific Aim 2 will explore exogenous PBEF involvement in NF-(B-dependent innate immunity pathways in lung endothelium, possibly via Interferon-Induced Transmembrane 3 protein, IFITM3, a novel PBEF binding partner that we ..
  37. Mechanisms for cell specific modulation of proliferation and migration
    Thomas S Monahan; Fiscal Year: 2013
    ..therapy would inhibit vascular smooth muscle cell proliferation and migration without negatively impacting the endothelium. We have identified a promising candidate, the myristolated alanine-rich C kinase substrate (MARCKS), a ..
  38. Vitamin D and Arterial Function in Patients with Chronic Kidney Disease
    Jessica B Kendrick; Fiscal Year: 2013
    ..in stage IIIB and stage IV CKD patients with vitamin D insufficiency or deficiency on conduit artery endothelium- dependent dilation (EDD) measured by brachial artery flow-mediated dilation (FMD)...
  39. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..feature of PM-associated cardiovascular disorders is the establishment and maintenance of a dysfunctional endothelium. Because endothelial dysfunction is an early symptom of cardiovascular disease and an important factor in acute ..
  40. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..types is mediated by transcobalamin (TC), a Cbl binding protein in the circulation, secreted by the vascular endothelium and a ubiquitous transcobalamin receptor (TCblR/CD320) that specifically binds TC saturated with Cbl and ..
  41. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    ..growth factor (VEGF) is a potent mitogen and critical survival and maintenance factor for lung vascular endothelium. VEGF and its down-stream mediator, nitric oxide (NO), are essential for lung angiogenesis during early ..
  42. SFRP2 and NFAT are therapeutic targets in angiosarcoma
    NANCY K DEMORE; Fiscal Year: 2013
    ..we identified secreted frizzled related protein 2 (SFRP2) as a gene with increased expression in tumor endothelium. SFRP2 is a 33kd secreted protein involved in Wnt signaling...
  43. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The lining of the microvasculature, the endothelium, communicates nutrient needs of cells to upstream vessels via gap junctional coupling, thereby matching local ..
  44. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    ..Furthermore, here has been recent evidence that sympathetic neurons, in addition to the endothelium, release t-PA in response to bradykinin in vivo...
  45. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ..have obtained the first definitive in vivo evidence to show that insulin has "anti-atherogenic" actions in the endothelium, since mice with deletion of both insulin receptors in the endothelial cells (EC) and apolipoprotein E (apoE-/-)..
  46. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ..activates endothelin A receptor (ETAR) in vascular smooth muscle to induce vasoconstriction, and ETBR in the endothelium to induce the release of vasodilator substances...
  47. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bioengineered corneal endothelium is being explored as an exciting, practical alternative to corneal transplantation to treat vision loss due to endothelial injury or disease...
  48. Prevention of high fat diet-induced vascular injury
    Ming Hui Zou; Fiscal Year: 2013
    ..activity, and (4) to assess the effects of AMPK on endothelial function and atherosclerosis in mice with the endothelium-specific depletion of AMPK (Tg-Cre-AMPK 11 or 12 (flox/flox), loss-of function) or in mice with the endothelium-..
  49. Redox Regulation of SERCA by Nitric Oxide
    Richard A Cohen; Fiscal Year: 2013
    ..the high levels of reactive oxygen and nitrogen species (ROS/RNS) present in diseased arteries, the function of endothelium-derived nitric oxide (7NO) is decreased, and this contributes to the growth of vascular lesions...
  50. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2013
    ..act as agonist or antagonist of human P2Y2, P2Y4, P2Y6, or P2X1 receptors, and had good safety margin in the endothelium P2Y-dependent guinea pig aorta relaxation model...
    Marcos Intaglietta; Fiscal Year: 2011
    ..one that provides a fundamentally different treatment of ischemia, based on enhancement of microvascular flow, cardiac and renal functions, repair of the endothelium and delivery of heme ligands (O2, NO and CO).
  52. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2013
    ..dependent mechanisms but that the formation of thromboses requires other inflammatory mediators to activate the endothelium. We will test the hypothesis that one mechanism for this "second hit" is endothelial cell death mediated via ..
  53. Modeling distinct neonatal purine metabolism to inform vaccine development
    Ofer Levy; Fiscal Year: 2013
    ..adult tissue construct (ATC), comprised of extracellular matrix, autologous plasma, and an overlying endothelium upon which cryopreserved cord blood- or peripheral blood-mononuclear cells or CD33-selected Mos extravasate and ..
  54. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2010
    ..We propose that myocardial reperfusion injury to the endothelium will be modest in TNF-alpha knockout (TNF-/-) mice, severe in TNF-alpha over-expression (TNF++/++) mice, and ..
  55. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..Unfortunately, SKA-31 also activates KCa3.1 channels, which are expressed on vascular endothelium, and thus reduces blood pressure in mice...
  56. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..effects of exercise on the SIRT1/LKB1/AMPK/eNOS signaling mechanism that it has recently identified in the endothelium of the mouse aorta and is presently studying in other tissues...
  57. Pososome Regulated Monocyte/Macrophage Tissue Infiltration
    Dianne Cox; Fiscal Year: 2013
    ..the Src family tyrosine kinase Hck mediates WASP phosphorylation, which is required for MD diapedesis across an endothelium. In Specific Aim 1 we will determine the role of Intersectin 2L, a protein that only binds to phosphorylated ..
  58. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..Challenge Topic (04-HL- 103): Assess the role of leukocyte interactions with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  59. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..and ovariectomy induce irreversible changes in the cardiovascular system that frequently result in diminished endothelium-dependent regulation of vascular tone and can lead to hypertension...
  60. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..image the retinal vasculature in vivo to monitor molecular expression and cellular recruitment to inflammatory endothelium. Our experimental design will allow us to follow disease progression within a single animal over time...
  61. Endothelial Lipoxygenase Metabolites and Vascular Tone
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endothelial cells release nitric oxide, prostaglandin I2 and endothelium-derived hyperpolarizing factor (EDHF) that reduce vascular tone and counteract vasoconstriction...
  62. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..Prior to the development of airway fibrosis in rejecting allografts, C3 deposits on the vascular endothelium just as tissue hypoxia is first detected...
  63. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..We found that Pf-IRBC but not non-infected RBC activate BBB endothelium: increase ICAM-1 expression on HBMEC, release cytokines &chemokines and decrease barrier integrity...
    WILLIAM MAYHAN; Fiscal Year: 1992
    Proposed studies will examine two aspects of endothelium in the cerebral circulation: permeability of the blood-brain barrier (BBB), and modulation of vascular responses...
  65. Modulation of Monocarboxylic Acid Transporter Kinetic Function for Stroke Therapy
    JEFFREY PAUL SMITH; Fiscal Year: 2010
    ..MCT1 is the sole facilitator of lactic acid transport across the blood brain barrier's cerebrovascular endothelium. Therefore it is important in brain metabolism where lactate is an important energy substrate, and during ..
    Michael Lawrence; Fiscal Year: 1999
    ..investigator's abstract) Immunologic responses to infection depend on adhesive interactions between leukocytes, endothelium, and platelets...
    Michael Heymann; Fiscal Year: 1999
    ..Although recent physiological advances have highlighted the role of the vascular endothelium in contributing to these changes, of primary importance in this respect are nitric oxide (NO) and PGI2, both of ..
  68. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2010
    ..reduced by a significant loss of cells due to the absence of the signals to guide the cells to the injured endothelium. The objectives of this proposed study are to develop a nano-sized cell guidance molecule and attach it to the ..
  69. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    ..actions of relaxin hinge on bi-directional communication between the vascular smooth muscle and the endothelium. Preliminary data indicate that the major relaxin receptor, Lgr7, mediates the renal vasodilatory and arterial ..
    Pin Lan Li; Fiscal Year: 2000
    b>Endothelium-dependent vasodilation plays an important role in the control of coronary vascular tone...
  71. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..Insulin resistance states, including type 2 diabetes mellitus, are associated with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function ..
    William Pearce; Fiscal Year: 1992
    ..First, experiments will be conducted to test the hypothesis that the vascular endothelium makes a greater contribution to hypoxic relaxation in adult than in newborn cerebral arteries...
  73. GATA Factor Regulation of Vascular Endothelium
    EMERY BRESNICK; Fiscal Year: 2009
    ..However, mechanisms underlying GATA-2 function and regulation in endothelium are unknown...
    Changyi Chen; Fiscal Year: 2004
    DESCRIPTION (Adapted from the applicant's abstract) 1). To define the role of HIV protease inhibitors in endothelium-dependent vasorelaxation and endothelial morphology...
    David Stern; Fiscal Year: 1992
    Recent studies have indicated that stimulation of endothelium by physiologic mediators results in suppression of anticoagulant and enhancement of procoagulant properties...
    John Keaney; Fiscal Year: 2000
    ..Normally, the endothelium maintains vascular homeostasis, in part, through the action of endothelium-derived nitric oxide (EDNO)...
    JOE GARCIA; Fiscal Year: 2001
    The vascular endothelium is a selective cellular barrier to circulatory proteins and is critical to vessel wall homeostasis...
    Christopher Wright; Fiscal Year: 2002
    ..either by homologous recombination-Mf1/lacZ-or as a result of spontaneous mutation-Mf1/Ch) the corneal endothelium fails to differentiate from the embryonic corneal mesenchyme...
  79. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..Previous studies have suggested that interleukin-6 (IL-6)-induced pro-inflammatory environments in the vascular endothelium are critical for the initiation and development of atherosclerosis...