epithelium

Summary

Summary: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.

Top Publications

  1. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  2. pmc XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberg
    Department of Pathology and Cell Biology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:16351-6. 2009
  3. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
  4. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
  5. pmc The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    Jonathan M Lee
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Cell Biol 172:973-81. 2006
  6. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
  7. pmc The human keratins: biology and pathology
    Roland Moll
    Institute of Pathology, Philipps University, 35033, Marburg, Germany
    Histochem Cell Biol 129:705-33. 2008
  8. doi Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    Toshiro Sato
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:1762-72. 2011
  9. pmc Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models
    Ruth Perets
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 24:751-65. 2013
  10. ncbi Parallels between tissue repair and embryo morphogenesis
    Paul Martin
    Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Development 131:3021-34. 2004

Research Grants

  1. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
  2. RODNEY JON SCHLOSSER; Fiscal Year: 2014
  3. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
  4. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
  5. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
  6. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
  7. Brian Wong; Fiscal Year: 2014
  8. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
  9. Heather L Francis; Fiscal Year: 2015
  10. SUSAN F KEAY; Fiscal Year: 2016

Detail Information

Publications432 found, 100 shown here

  1. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  2. pmc XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberg
    Department of Pathology and Cell Biology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:16351-6. 2009
    ..Our observations provide evidence for an association of XMRV with malignant cells and with more aggressive tumors...
  3. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  4. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
    ..in several transgenic strains carrying the activated neu transgene, expression of unactivated neu in the mammary epithelium resulted in the development of focal mammary tumors after long latency...
  5. pmc The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    Jonathan M Lee
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Cell Biol 172:973-81. 2006
    ..E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996-6000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991-5995)...
  6. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
    ..The limb truncations are due to a failure to maintain the apical ectodermal ridge, a stratified epithelium, essential for limb development...
  7. pmc The human keratins: biology and pathology
    Roland Moll
    Institute of Pathology, Philipps University, 35033, Marburg, Germany
    Histochem Cell Biol 129:705-33. 2008
    ..Future research might open further fields of clinical application for this remarkable protein family...
  8. doi Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    Toshiro Sato
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:1762-72. 2011
    ..We have adapted the culture conditions to grow similar epithelial organoids from mouse colon and human small intestine and colon...
  9. pmc Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models
    Ruth Perets
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 24:751-65. 2013
    ..These findings offer an avenue to address clinically important questions that are critical for cancer prevention and early detection in women carrying BRCA1 and BRCA2 mutations. ..
  10. ncbi Parallels between tissue repair and embryo morphogenesis
    Paul Martin
    Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Development 131:3021-34. 2004
    ..In the embryo, both morphogenesis and repair are achieved with a perfect end result, whereas repair of adult tissues leads to scarring. We discuss whether this may be due to the adult inflammatory response, which is absent in the embryo...
  11. pmc Occludin: a novel integral membrane protein localizing at tight junctions
    M Furuse
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Biol 123:1777-88. 1993
    ..These findings revealed that an integral membrane protein localizing at tight junctions is now identified, which we designated as "occludin."..
  12. pmc Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium
    Eva Böttcher
    Institute of Virology, Philipps University, Hans Meerwein str 3, 35043 Marburg, Germany
    J Virol 80:9896-8. 2006
    ..These data suggest that TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo...
  13. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    To directly test the contribution of Scgb1a1(+) Clara cells to postnatal growth, homeostasis, and repair of lung epithelium, we generated a Scgb1a1-CreER "knockin" mouse for lineage-tracing these cells...
  14. doi Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila
    Benoit Aigouy
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Cell 142:773-86. 2010
    ..Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape...
  15. ncbi Math1: an essential gene for the generation of inner ear hair cells
    N A Bermingham
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 284:1837-41. 1999
    ..Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells...
  16. pmc CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
    Rhonda L Brown
    Department of Medicine, Division of Hematology Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    J Clin Invest 121:1064-74. 2011
    ..Together, our data suggest that regulation of CD44 alternative splicing causally contributes to EMT and breast cancer progression...
  17. ncbi Evidence that stem cells reside in the adult Drosophila midgut epithelium
    Craig A Micchelli
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 439:475-9. 2006
    ..Using genetic mosaic analysis we demonstrate that differentiated cells in the epithelium arise from a common lineage...
  18. doi Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    Jelena Nedjic
    Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
    Nature 455:396-400. 2008
    ..In doing so, it contributes to T-cell selection and is essential for the generation of a self-tolerant T-cell repertoire...
  19. doi The sentinel role of the airway epithelium in asthma pathogenesis
    Stephen T Holgate
    Allergy and Inflammation Research, Division of Infection, Inflammation and Immunity, School of Medicine, Southampton University and General Hospital, Southampton, Hampshire, UK
    Immunol Rev 242:205-19. 2011
    ..reticularis provides evidence for ongoing epithelial barrier dysfunction, while physical distortion of the epithelium consequent upon repeated bronchoconstriction provides additional stimuli for remodeling...
  20. ncbi Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    V Kaartinen
    Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
    Nat Genet 11:415-21. 1995
    ..This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction...
  21. ncbi Mesothelial cells: their structure, function and role in serosal repair
    Steven E Mutsaers
    Asthma and Allergy Research Institute and Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Respirology 7:171-91. 2002
    ..In the present review, the current understanding of the structure and function of the mesothelium and the biology of mesothelial cells is discussed, together with recent insights into the mechanisms regulating its repair...
  22. pmc Gene expression profiles of estrogen receptor-positive and estrogen receptor-negative breast cancers are detectable in histologically normal breast epithelium
    Kelly Graham
    Genetics and Genomics Program and Department of Pathology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA
    Clin Cancer Res 17:236-46. 2011
    Previously, we found that gene expression in histologically normal breast epithelium (NlEpi) from women at high breast cancer risk can resemble gene expression in NlEpi from cancer-containing breasts...
  23. doi Transcriptional regulation of cell polarity in EMT and cancer
    G Moreno-Bueno
    Departamento de Bioquimica, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 27:6958-69. 2008
    ..These recent observations provide new insights into the relationship between alterations in cell polarity components and EMT in cancer, opening new avenues for their potential use as therapeutic targets to prevent tumour progression...
  24. pmc Gene expression in histologically normal epithelium from breast cancer patients and from cancer-free prophylactic mastectomy patients shares a similar profile
    K Graham
    Boston University School of Medicine and Boston Medical Center, MA, USA
    Br J Cancer 102:1284-93. 2010
    We hypothesised that gene expression in histologically normal (HN) epithelium (NlEpi) would differ between breast cancer patients and usual-risk controls undergoing reduction mammoplasty (RM), and that gene expression in NlEpi from cancer-..
  25. ncbi Molecular requirements for epithelial-mesenchymal transition during tumor progression
    Margit A Huber
    Department of Dermatology, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Opin Cell Biol 17:548-58. 2005
    ..Increasing evidence suggests that EMT plays a specific role in the migration of cells from a primary tumor into the circulation and may provide a rationale for developing more effective cancer therapies...
  26. pmc Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Biol Cell 14:1790-800. 2003
    ..of TNF-alpha and TGF-beta signaling promotes a rapid morphological conversion of the highly organized colonic epithelium to dispersed cells with a mesenchymal phenotype, and this process is dependent on enhanced p38 MAPK activity...
  27. ncbi Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
    Marcus Mall
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, 7011 Thurston Bowles Building, Chapel Hill, North Carolina 27599 7248, USA
    Nat Med 10:487-93. 2004
    ..We conclude that increasing airway Na(+) absorption initiates cystic fibrosis-like lung disease and produces a model for the study of the pathogenesis and therapy of this disease...
  28. ncbi Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis
    Annie N Y Ng
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Dev Biol 286:114-35. 2005
    ..these studies by providing an analysis of the morphological events that shape the zebrafish intestinal epithelium. One of our goals is to provide a framework for the future characterization of zebrafish mutant phenotypes in ..
  29. ncbi Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium
    D Z Chen
    North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 131:3294-302. 2001
    ..mice, which develop cervical cancer after chronic estradiol exposure, apoptotic cells were detected in cervical epithelium by TdT-mediated dUTP nick-end labeling staining and by immunohistochemical staining of active caspase 3 only in ..
  30. ncbi Signalling to and from tight junctions
    Karl Matter
    Division of Cell Biology, Institute of Ophthalmology, University College London, London, UK
    Nat Rev Mol Cell Biol 4:225-36. 2003
    ..They receive and convert signals from the cell interior to regulate junction assembly and function, and transmit signals to the cell interior to modulate gene expression and cell behaviour...
  31. pmc Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA
    C Meyers
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Virol 71:7381-6. 1997
    ..HPV18 virions purified by isopycnic gradient were capable of infecting keratinocytes in vitro, as shown by the expression of multiple HPV18-specific, spliced transcripts...
  32. ncbi Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
    Masato Maeda
    Department of Oral Biology College of Dentistry, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Cell Sci 118:873-87. 2005
    b>Epithelium-to-mesenchyme transitions (EMTs) are characterized by morphological and behavioral changes in cells. During an EMT, E-cadherin is downregulated while N-cadherin is upregulated...
  33. doi Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    Ying Li
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 147:629-40. 2011
    ..AhR activity can be regulated by dietary components, such as those present in cruciferous vegetables, providing a mechanistic link between dietary compounds, the intestinal immune system, and the microbiota...
  34. doi Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell
    Shiro Yui
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Nat Med 18:618-23. 2012
    ..The transplanted donor cells readily integrated into the mouse colon, covering the area that lacked epithelium as a result of the introduced damage in recipient mice...
  35. ncbi Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
    Junichi Ikenouchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Sci 116:1959-67. 2003
    Snail is a transcription repressor that plays a central role in the epithelium-mesenchyme transition (EMT), by which epithelial cells lose their polarity...
  36. doi Bacterial interactions with the host epithelium
    Minsoo Kim
    Department of Infectious Disease Control, International Research Center for Infectious Diseases, University of Tokyo 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cell Host Microbe 8:20-35. 2010
    The gastrointestinal epithelium deploys multiple innate defense mechanisms to fight microbial intruders, including epithelial integrity, rapid epithelial cell turnover, quick expulsion of infected cells, autophagy, and innate immune ..
  37. pmc p63 is the molecular switch for initiation of an epithelial stratification program
    Maranke I Koster
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 18:126-31. 2004
    ..Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis...
  38. pmc GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Hosein Kouros-Mehr
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 127:1041-55. 2006
    ..We identified GATA-3 as the most highly enriched transcription factor in the mammary epithelium of pubertal mice...
  39. doi Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity
    Sumitaka Hagiwara
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 99:1916-23. 2008
    ..These findings suggest that CD109 plays a role in the development of oral cancers, and is a useful prognostic marker to predict malignant transformation of premalignant lesions...
  40. pmc Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila
    Tatsushi Igaki
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Dev Cell 16:458-65. 2009
    ..Our data indicate that TNF signaling and the endocytic machinery could be components of an evolutionarily conserved fail-safe mechanism by which animals protect against neoplastic development...
  41. pmc Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration
    Deborah J Andrew
    Department of Cell Biology and Center for Cell Dynamics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Biol 341:34-55. 2010
    ....
  42. pmc Gene expression profile of the regeneration epithelium during axolotl limb regeneration
    Leah J Campbell
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
    Dev Dyn 240:1826-40. 2011
    ..requires several key tissues including a regeneration-competent wound epidermis called the regeneration epithelium (RE). We used microarray analysis to profile gene expression of the RE in the axolotl, a Mexican salamander...
  43. pmc Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium
    Yong Fu
    Department of Biochemistry, University of Southern California Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Proc Natl Acad Sci U S A 105:19444-9. 2008
    ..Here, we report that homozygous deletion of Grp78 specifically in mouse prostate epithelium suppresses prostate tumorigenesis without affecting postnatal prostate development and growth...
  44. pmc Shiga toxin 2 targets the murine renal collecting duct epithelium
    Mitchell A Psotka
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
    Infect Immun 77:959-69. 2009
    ..Stx2 therefore targets the murine collecting duct, and this Stx2-induced injury can be blocked by inhibitors of apoptosis in vivo...
  45. pmc The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 136:3741-5. 2009
    ..development, the undifferentiated epithelial progenitors are located at the distal tips of the branching epithelium. To test this hypothesis, we used an Id2-CreER(T2) knock-in mouse strain to lineage trace the distal epithelial ..
  46. pmc Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair
    Isabel Campos
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal and Instituto Gulbenkian de Ciência, 2780 156 Oeiras, Portugal
    Genetics 184:129-40. 2010
    ..We show beta(Heavy)-spectrin (beta(H)) localization to the wound edges where it presumably exerts an essential function to bring the wound to normal closure...
  47. ncbi Epithelial-mesenchymal transitions in development and pathologies
    Jean Paul Thiery
    Unite Mixte de Recherche 144, Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Opin Cell Biol 15:740-6. 2003
    ..Current studies further emphasise the critical importance of EMT and provide a better molecular and functional definition of mesenchymal cells and how they emerged >500 million years ago as a key event in evolution...
  48. ncbi N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish
    Elim Hong
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Development 133:3895-905. 2006
    ....
  49. pmc The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    K Aigner
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, Vienna, Austria
    Oncogene 26:6979-88. 2007
    ..In invasive ductal and lobular breast cancer, upregulation of ZEB1 was stringently coupled to cancer cell dedifferentiation. Our data show that ZEB1 represents a key player in pathologic EMTs associated with tumour progression...
  50. pmc A single progenitor population switches behavior to maintain and repair esophageal epithelium
    David P Doupé
    Medical Research Council MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Science 337:1091-3. 2012
    Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial...
  51. pmc Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche
    Andrea Flesken-Nikitin
    Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA
    Nature 495:241-5. 2013
    ..Some epithelial cancers are known to occur in transitional zones between two types of epithelium, whereas others have been shown to originate in epithelial tissue stem cells...
  52. ncbi The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium
    Johan D Heilborn
    Department of Dermatology, Karolinska Institute, Stockholm, Sweden
    J Invest Dermatol 120:379-89. 2003
    ..hCAP18 is detected in the inflammatory infiltrate and in the epithelium migrating over the wound bed...
  53. pmc Dicer function is essential for lung epithelium morphogenesis
    Kelley S Harris
    Laboratory of Genetics, University of Wisconsin, 425 G Henry Mall, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:2208-13. 2006
    ..Therefore, to study Dicer function in the later event of lung formation, we inactivated it in the mouse lung epithelium using a Dicer conditional allele and the Sonic Hedgehogcre (Shhcre) allele...
  54. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
    ....
  55. doi The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
    Stephen T Holgate
    Infection, Inflammation and Immunity Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton SO166YD, UK
    Proc Am Thorac Soc 6:655-9. 2009
    ..Evidence is provided to show that both the physical and functional barrier of the airway epithelium is defective in asthma with disrupted tight junctions, reduced antioxidant activity, and impaired innate ..
  56. ncbi The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    Elizabeth D Hay
    Harvard Medical School, Department of Cell Biology, Boston, Massachusetts 02115, USA
    Dev Dyn 233:706-20. 2005
    ..The creation of this cell is a remarkable process, one where a tightly knit, impervious epithelium suddenly extends filopodia from its basal surface and gives rise to migrating cells...
  57. pmc E-cadherin null mutant embryos fail to form a trophectoderm epithelium
    L Larue
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 91:8263-7. 1994
    ..At the blastocyst stage, E-cadherin-negative embryos failed to form a trophectodermal epithelium or a blastocyst cavity...
  58. ncbi Forces for morphogenesis investigated with laser microsurgery and quantitative modeling
    M Shane Hutson
    Department of Physics and Free Electron Laser Laboratory, Duke University, Durham, NC 27708, USA
    Science 300:145-9. 2003
    ....
  59. ncbi The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles
    J B Gurdon
    J Embryol Exp Morphol 10:622-40. 1962
  60. pmc Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
    Marjorie Jenny
    INSERM U381, 3 avenue Moliere, 67200, Strasbourg, France
    EMBO J 21:6338-47. 2002
    ..expression and the function of ngn3 in the control of endocrine cell development in the intestinal and gastric epithelium. Our results indicate that as in the pancreas, gastrointestinal endocrine cells derive from ngn3-expressing ..
  61. doi Transitions between epithelial and mesenchymal states in development and disease
    Buzz Baum
    Department of Cell and Developmental Biology, UCL, London, UK
    Semin Cell Dev Biol 19:294-308. 2008
    ..Nat Rev Mol Cell Biol 2006;7:131-42; Hay ED, Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am J Kidney Dis 1995;26:678-90]...
  62. pmc Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression
    Laurie G Hudson
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM, USA
    Clin Exp Metastasis 25:643-55. 2008
    The mesodermally derived normal ovarian surface epithelium (OSE) displays both epithelial and mesenchymal characteristics and exhibits remarkable phenotypic plasticity during post-ovulatory repair...
  63. pmc Unique morphological features of the proliferative zones and postmitotic compartments of the neural epithelium giving rise to striate and extrastriate cortex in the monkey
    Iain H M Smart
    Cerveau et Vision, Unité 371 INSERM, 18 Avenue Doyen Lepine, 69675 Bron Cedex, France
    Cereb Cortex 12:37-53. 2002
    ....
  64. pmc Molecular bases of cell-cell junctions stability and dynamics
    Matthieu Cavey
    IBDML, UMR CNRS Université de la Méditerranée, Marseille, France
    Cold Spring Harb Perspect Biol 1:a002998. 2009
    ....
  65. doi Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk
    Moshe Biton
    Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Immunol 12:239-46. 2011
    Colonic homeostasis entails epithelium-lymphocyte cooperation, yet many participants in this process are unknown...
  66. pmc Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations
    Laura C Greaves
    Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 8:e1003082. 2012
    ..These data provide little evidence for any selective constraints on the occurrence and expansion of mtDNA mutations in somatic cells of the human colon during human ageing in contrast to germline mutations seen in the general population...
  67. pmc Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes
    Allison Choyce
    The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia
    PLoS ONE 8:e57798. 2013
    ..In a mouse model of premalignant skin epithelium, transgenic mice that express the human papillomavirus type 16 (HPV16) E7 oncoprotein under a keratin 14 ..
  68. pmc Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development
    Audrey V Parent
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0540, USA
    Cell Stem Cell 13:219-29. 2013
    ..Thus, hESC-derived TEP grafts may have broad applications for enhancing engraftment in cell-based therapies as well as restoring age- and stress-related thymic decline. ..
  69. ncbi Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature
    Liqing Zhao
    Department of Medicine, University of California, Box 2911, San Francisco, CA 94143 2911, USA
    Mech Dev 122:877-86. 2005
    ..VEGF is expressed by epithelium and the receptors in the surrounding mesenchyme...
  70. pmc Lack of Foxp3 function and expression in the thymic epithelium
    Adrian Liston
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 204:475-80. 2007
    ..Here, we used genetic tools to demonstrate that the thymic epithelium does not express Foxp3...
  71. pmc Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma
    Jeffrey L Spees
    Center for Gene Therapy, Tulane Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 100:2397-402. 2003
    ..A subset of the hMSCs rapidly differentiated into epithelium-like cells, and they restored the epithelial monolayer...
  72. ncbi A homolog of Drosophila grainy head is essential for epidermal integrity in mice
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Science 308:411-3. 2005
    ..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
  73. ncbi Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis
    Ali Nawshad
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Cells Tissues Organs 179:11-23. 2005
    ..Here we assess the biochemical signaling pathways of TGF-beta and their potential cross-interaction with traditional Wnt signaling molecules to bring about EMT during embryogenesis and tumor metastasis...
  74. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
  75. pmc The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2
    Quanxi Li
    Department of Comparative Biosciences, University of Illinois Urbana Champaign, Urbana, IL 61820, USA
    Science 331:912-6. 2011
    ..However, the mechanism for this is not clear. The attenuation of estrogen-mediated proliferation of the uterine epithelium by progesterone is a prerequisite for successful implantation...
  76. pmc Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell-containing epithelium
    Weitian Liu
    Pathology Department, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 104:816-24. 2009
    The mucosa of patients with columnar-lined esophagus recognized on endoscopy usually shows epithelium with and without goblet cells...
  77. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
    ....
  78. pmc Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19
    Arturo Ramirez-Miranda
    Cornea and Uveitis Division, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA
    Mol Vis 17:1652-61. 2011
    To evaluate the expression patterns of cytokeratin (K) 12, 13, and 19 in normal epithelium of the human ocular surface to determine whether K13 could be used as a marker for conjunctival epithelium.
  79. doi The mouse ovarian surface epithelium contains a population of LY6A (SCA-1) expressing progenitor cells that are regulated by ovulation-associated factors
    Lisa F Gamwell
    Center for Cancer Therapeutics, Ottawa Hospital Research Institute, Ontario, Canada
    Biol Reprod 87:80. 2012
    The ovarian surface epithelium, a single layer of poorly differentiated epithelial cells, covers the surface of the ovary and is ruptured during ovulation...
  80. ncbi A zonal organization of odorant receptor gene expression in the olfactory epithelium
    K J Ressler
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Cell 73:597-609. 1993
    ..capacity, we have examined the spatial distribution of odorant receptor RNAs in the mouse olfactory epithelium. We have observed topographically distinct patterns of receptor RNAs suggesting that the nasal cavity is divided ..
  81. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
    ..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
  82. pmc Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation
    Matthew J Naylor
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 171:717-28. 2005
    ..the development and function of a range of tissues; however, little is known about its role in glandular epithelium. To assess the contribution of beta1 integrin, we conditionally deleted its gene in luminal epithelia during ..
  83. ncbi TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium
    Sophie Chabot
    Department of Pediatrics, Harvard Medical School, GI Cell Biology Laboratory, Children s Hospital Boston and Harvard Digestive Diseases Center, Boston, MA 02115, USA
    J Immunol 176:4275-83. 2006
    ..Mucosal lymphoid follicles are covered by a specialized follicle-associated epithelium (FAE) that contains M cells, which mediate uptake and transepithelial transport of luminal Ags...
  84. ncbi Endocrine signaling in ovarian surface epithelium and cancer
    Peter C K Leung
    Department of Obstetrics and Gynecology, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia, Canada
    Hum Reprod Update 13:143-62. 2007
    ..Greater than 85% of human ovarian cancer arises within the ovarian surface epithelium (OSE), with the remainder derived from granulosa cells or, rarely, stroma or germ cells...
  85. pmc Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis
    Robert P Schleimer
    Northwestern University Feinberg School of Medicine, Division of Allergy Immunology, 240 E Huron, McGaw M318, Chicago, IL 60611, USA
    Proc Am Thorac Soc 6:288-94. 2009
    ..The main emphasis of our work has been to focus on the roles that epithelium, in the sinuses and upper airways, plays as both a mediator and regulator of immune and inflammatory responses...
  86. pmc Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis
    K Levanon
    Department of Medical Oncology, Center of Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Oncogene 29:1103-13. 2010
    Recent studies suggest that some serous ovarian carcinomas (SOCs) arise from the fallopian tube (FT) epithelium rather than the ovarian surface epithelium...
  87. pmc Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden
    L Connelly
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Oncogene 30:1402-12. 2011
    ..doxycycline (dox)-inducible mouse model, termed DNMP, to inhibit NF-κB activity specifically within the mammary epithelium during tumor development in the polyoma middle T oncogene (PyVT) mouse mammary tumor model...
  88. ncbi Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis
    Fereshteh Parviz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 34:292-6. 2003
    ..functional differentiation of hepatocytes, accumulation of hepatic glycogen stores and generation of a hepatic epithelium. We show that Hnf4alpha is a dominant regulator of the epithelial phenotype because its ectopic expression in ..
  89. ncbi Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium
    Yaron Daniely
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, Triangle Park, NC 27709, USA
    Am J Physiol Cell Physiol 287:C171-81. 2004
    ..In the adult pseudostratified, columnar tracheal epithelium, K14(+)/K5(+)/BS-I-B4(+) basal cells stain most intensely for p63, whereas ciliated and mucosecretory cells are ..
  90. ncbi Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
    Honor Hugo
    Embryology Laboratory, Murdoch Children s Research Institute, The Royal Children s Hospital, Victoria, Australia
    J Cell Physiol 213:374-83. 2007
    ..Finally, perspectives from a clinical and translational viewpoint are discussed...
  91. ncbi Sry induces cell proliferation in the mouse gonad
    J Schmahl
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 127:65-73. 2000
    ..This male-specific proliferation was observed initially in the cells of the coelomic epithelium and occurred in two distinct stages...
  92. ncbi The role of epithelial-mesenchymal transition in cancer pathology
    Marcello Guarino
    Department of Anatomical Pathology, Hospital of Vimercate Milan, Italy
    Pathology 39:305-18. 2007
    ..Since the molecules involved in EMT represent potential targets for pharmacological agents, these findings open new avenues for the control of metastatic spread in the treatment of malignancies...
  93. ncbi N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
    Sanae Nakajima
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 10:4125-33. 2004
    ..The purpose of the study presented here was to investigate whether a gain in N-cadherin in pancreatic cancer is involved in the process of metastasis via EMT and whether its expression is affected by growth factors...
  94. ncbi The structure of the choroid plexus and the physiology of the choroid plexus epithelium
    Zoran B Redzic
    School of Biomedical Sciences, Hodgkin Building, Guy s Campus, London, SE1 1UL, United Kingdom
    Adv Drug Deliv Rev 56:1695-716. 2004
    ..The CPs also synthesise the thyroid transporting protein transthyretin and transferrin and can chelate heavy metals...
  95. ncbi Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
    P Sheth
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 293:G308-18. 2007
    Bile duct epithelium forms a barrier to the backflow of bile into the liver parenchyma. However, the structure and regulation of the tight junctions in bile duct epithelium is not well understood...
  96. pmc Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice
    Yuxin Feng
    Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:14718-23. 2007
    ..that this steroid hormone receptor is required in the mammary stroma that subsequently exerts its effect on the epithelium through additional paracrine signaling events...
  97. pmc Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    Nan Gao
    Department of Genetics, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 16:588-99. 2009
    ..homeobox transcription factor Cdx2 from early endoderm results in the replacement of the posterior intestinal epithelium with keratinocytes, a dramatic cell fate conversion caused by ectopic activation of the foregut/esophageal ..
  98. doi Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition
    Marcello Guarino
    Department of Pathology, Hospital of Vimercate, Vimercate, Milan, Italy
    Hum Pathol 40:1365-76. 2009
    ..Markers of epithelium undergoing epithelial-mesenchymal transition include loss of E-cadherin and cytokeratin; de novo expression of ..
  99. ncbi Molecular patterning of the oikoplastic epithelium of the larvacean tunicate Oikopleura dioica
    F Spada
    Sars International Centre for Marine Molecular Biology, Bergen High Technology Centre, N-5008 Bergen, Norway
    J Biol Chem 276:20624-32. 2001
    ..A monolayer of cells covering the trunk of the animal, the oikoplastic epithelium, secretes the house...
  100. ncbi Epithelial-mesenchymal transitions: twist in development and metastasis
    Yibin Kang
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cell 118:277-9. 2004
    ..A recent report in Cell (Yang et al., 2004) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases...
  101. ncbi Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Int J Oncol 31:277-83. 2007
    ..It is possible that therapeutic benefits such as the restoration of chemosensitivity or suppression of metastasis will be enabled by gaining further insight into the mechanisms underlying chemoresistance and EMT...

Research Grants79

  1. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..The possibility that soy isoflavones act directly in the seminiferous epithelium will be investigated by analysis of Sertoli cell differentiation and maturation...
  2. RODNEY JON SCHLOSSER; Fiscal Year: 2014
    ..We propose to achieve targeted delivery to and retention of SOD and CAT (antioxidants) on respiratory epithelium using biodegradable polylactic acid (PLA) nanoparticles (NPs)...
  3. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..Secreted from goblet cells on the surface epithelium and mucus cells in the submucosal glands, mucins not only are the major determinant of the viscoelastic ..
  4. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..by applicant): The homeostatic balance between proliferation and apoptosis is essential for the intestinal epithelium to function as a physiological and structural barrier...
  5. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..influenzae during stages of pathogenesis in which it encounters sites such as the mucosal epithelium, bloodstream, and lungs that differ with respect to both oxygen availability and the presence of antimicrobial ..
  6. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..This VLP is capable of encapsulating DNA vaccine in vitro, delivering DNA vaccine to epithelium cell at gastrointestinal tract, and inducing antigen-specific humoral and cellular immune responses...
  7. Brian Wong; Fiscal Year: 2014
    ..OCT allows for one to distinguish the epithelium from the underlying tissue microstructures based on tissue optical properties with real-time frame rates...
  8. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
    ..In corneal epithelium, the transgene expression causes decreased expression of adhesion molecule BP180 and defective hemidesmosomes, ..
  9. Heather L Francis; Fiscal Year: 2015
    ..the extent and the signaling mechanisms involved through which the proliferation/damage of the biliary epithelium is regulated by the autocrine synthesis of histamine by HDC...
  10. SUSAN F KEAY; Fiscal Year: 2016
    ..consistent findings in bladder biopsies from BPS/IC patients, including denudation, tears, or thinning of the epithelium, coupled with abnormal proteoglycan and protein expression (including tight junction and adherens proteins, ..
  11. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..The mechanism involves possible transport through the neuroepithelial cells of olfactory epithelium as well as through trigeminal nerve pathways...
  12. John M Sullivan; Fiscal Year: 2016
    ..macular degeneration (dAMD), cellular and biochemical debris accumulates within and beneath the retinal pigment epithelium (RPE)...
  13. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..This model of engineered human skin develops a keratinized epithelium, basement membrane, and has a dermal substitute, but requires high inoculation densities, has a limited lifespan ..
  14. GARY ANDREW WEISMAN; Fiscal Year: 2016
    ..Progress has been made in strategies for the regeneration of a variety of tissues including skin, corneal epithelium, cartilage, bone and bladder...
  15. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..by erythematous, scaling, infiltrated plaques and histology that shows a markedly hyperproliferative epithelium (acanthosis) with infiltration of neutrophils and CD4+ (helper) and CD8+ (cytotoxic/suppressor) lymphocytes, as ..
  16. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..We hypothesize flavokawain A has chemopreventive effects on bladder epithelium via enhancing cell cycle regulation and increasing the sensitivity of apoptotic mechanisms...
  17. Mario Strazzabosco; Fiscal Year: 2016
    ..Furthermore, better knowledge of the regulation of TLR pathways in the biliary epithelium, will also provide important insights into the pathogenesis of other inflammation-mediated diseases of the ..
  18. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..Further, the defined cellular organization of taste epithelium will allow us to tease apart the functions of PKC4 in taste epithelium, and lead potentially to development of ..
  19. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..to genetic mutations in subjects with CF results in altered fluid and electrolyte transport across the airway epithelium leading to impaired mucociliary clearance which leads to chronic airway infection...
  20. ANASTACIA GRIEGO; Fiscal Year: 2016
    ..are small double-stranded DNA viruses that are highly species specific and possess a strict tropism for squamous epithelium. Over 150 HPV types are capable of infecting mucosal and cutaneous epithelium, the majority of these types cause ..
  21. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..sulfonic acid (TNBS) that elicits a localized chronic inflammatory response that undermines the integrity of the epithelium, and upregulates ROS, and a more "acute model" of ligature-induced periodontitis....
  22. Paul Feinstein; Fiscal Year: 2014
    ..to identify odors by humans is dependent on odorant receptors within olfactory neurons that line the nasal epithelium. This epithelium is under continuous cell division by a basal stem cell population that produces immature ..
  23. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    ..Oxidative damage to the retinal pigment epithelium (RPE) contributes to AMD by reducing the function of these cells and by stimulating an inflammatory cascade that ..
  24. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..More than 90% of head and neck malignancies are squamous cell carcinoma (SCC), originating from the epithelium which lines the UADT...
  25. C Yan Cheng; Fiscal Year: 2016
    ..g., male contraceptives that exert their effects by disrupting germ cell function in the seminiferous epithelium) that can be targeted to the seminiferous epithelium behind the BTB. Recent studies have shown that cytokines (e...
  26. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..by applicant): The nasal cavity in mammals houses distinct chemosensory epithelia including the main olfactory epithelium, the vomeronasal epithelium and the trigeminally innervated respiratory epithelium (so-called "non- sensory" ..
  27. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..retraction disrupts normal neurotrophin signaling among hair cells, supporting cells and neurons in the cochlear epithelium, and that this interruption initiates the slow cell-death cascade in SGCs...
  28. Nahid F Mivechi; Fiscal Year: 2016
    ..and (2) a model of spontaneous mammary tumorigenesis that expresses Her2/Neu directed to the mammary gland epithelium. In Aim 1, we will test the hypothesis that ablation of Hsf1, negatively impact cell transformation and HCC ..
  29. Robert Paine; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The pulmonary alveolar epithelium forms the largest surface of interaction of the human body with the external environment...
  30. Beth A McCormick; Fiscal Year: 2016
    ..and patient symptoms also correlate with the histologic finding of PMN infiltrates within the mucosa and surface epithelium. This same histological event of massive transepithelial migration of PMNs occurs in the acute phase of ..
  31. Zhiyong Zhao; Fiscal Year: 2016
    ..NTDs are caused by excessive programmed cell death (apoptosis) in the neural epithelium, which is executed by initiator caspase-8-triggered apoptotic signaling...
  32. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..normal alveolar epithelial cells homeostasis (the onset), followed-on by the diffuse activation of the alveolar epithelium (as a gateway for progression) and finally by aberrant epithelial repair...
  33. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..Efficient repair of respiratory epithelium and restoration of barrier function are essential for resolution of chlorine-induced lung injury...
  34. DAVID ANTONETTI; Fiscal Year: 2016
    ..Silencing occludin expression in retinal pigment epithelium cells induces a two-fold increase in cell proliferation...
  35. Yan Zhang; Fiscal Year: 2016
    Zhang Y. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Target ? Project Summary The Mentored Clinical Scientist Research Career Development Award (K08) candidate, Yan Zhang, earned her clinical degrees in ..
  36. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..e., when the architecture of the gastric epithelium is disrupted in vivo)...
  37. Radhakrishna Rao; Fiscal Year: 2014
    ..Using a cell culture model of the intestinal epithelium and human colonic biopsies we will determine that: 1) ADH1B and ALDH2 modulate ethanol-induced disruption of TJs ..
  38. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..I will do this by utilizing currently available alleles to remove ephrin-B2 from the palatal shelf epithelium, where it is highly expressed...
  39. Jennifer S Stone; Fiscal Year: 2014
    ..These processes have a variety of shapes and seem to contact other cells in the epithelium, including other type II hair cells...
  40. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..a fundamental process of organogenesis in multi-cellular organisms, involves transition of a mono-layered epithelium to a three- dimensional organ...
  41. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..our future plan includes testing of the isolated compounds in native preparations, such as neurons and epithelium, respectively...
  42. John R Hoidal; Fiscal Year: 2016
    ..A particular focus will be the role(s) of RAGE expressed on lung macrophages and alveolar epithelium since these are the primary sources of RAGE expression in the lungs of cigarette smokers...
  43. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..Finally, the mechanism by which LIF produced by decidualized uterine epithelium and/or macrophages contributes to the implantation process will be examined by studying its effects on ..
  44. Allen F Ryan; Fiscal Year: 2016
    ..of nonsensory cochlear cells into HCs have been identified, and epigenetic manipulation of the cochlear sensory epithelium to enhance gene expression induced by a viral vector has been performed...
  45. Anna Tate Riegel; Fiscal Year: 2015
    ..We will use mammary transplantation models to determine if continuous expression of AIB1 or ?3 in the A) epithelium or B) stroma is required for maintenance of mammary tumorigenesis and the tumor stromal response that includes ..
  46. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..verrucarum. We hypothesize that Bb initially infects the insect's midgut epithelium upon ingestion of a contaminated blood-meal...
  47. Alan M Hanash; Fiscal Year: 2016
    ..IL-22 is a recently characterized cytokine that has been shown to protect intestinal epithelium during experimental inflammatory bowel disease...
  48. John P Lynch; Fiscal Year: 2016
    ..provided by applicant): Barrett's esophagus (BE) is the replacement of the normal squamous esophageal epithelium with an intestinalized columnar epithelium...
  49. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..level of the molecular crosstalk that occurs between nontypeable Haemophilus influenzae (NTHI) and the mucosal epithelium of the NP;2) the polymicrobial disease OM (i.e...
  50. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..contrast to the success gene therapy approaches have had in other ocular tissues such as the retinal pigment epithelium (RPE) and specifically in animal models of Leber's congenital amaurosis...
  51. STEVEN HERBERT ABMAN; Fiscal Year: 2015
    ..VEGF treatment improves vascular and alveolar growth in experimental BPD yet has no direct effects on airway epithelium, we hypothesize that in addition to NO activation, VEGF-induced enhancement of lung structure may be mediated ..
  52. Jason C Mills; Fiscal Year: 2016
    ..intestines and the gastric antrum, relatively little is known about the stem cells of the gastric (body) corpus epithelium. Our overall goal is t better characterize the corpus stem cell under normal conditions and in response to ..
  53. The Role of RNA Splicing Factors in Retinal Degeneration
    Michael Farkas; Fiscal Year: 2012
    ..mice, we have found that mutations in PRPF3 and PRPF8 may cause vision loss by damaging the retinal pigment epithelium (RPE) cells of the retina. The RPE cells maintain the health of the photoreceptor cells...
  54. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..AMP peptide treatment protected the surface epithelium and connective tissue of the mouse tongue, and delayed the appearance and reduced the extent of ulcer formation ..
  55. Warren G Hill; Fiscal Year: 2014
    ..This project explores the role of integrins and integrin-signaling pathways within the epithelium lining the bladder - the urothelium - where almost nothing is known of their function...
  56. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..I will do this by utilizing currently available alleles to remove ephrin-B2 from the palatal shelf epithelium, where it is highly expressed...
  57. ERIN D GORDON; Fiscal Year: 2016
    ..Long considered a disease of the immune system, there is increasing recognition of the importance of the airway epithelium in orchestrating the immune responses in asthma...
  58. RUBIE ANN RAKIAN; Fiscal Year: 2016
    ..will address the capacity of bone marrow-derived mesenchymal stem cells (MSC) to regenerate the oral mucosa epithelium by mimicking an environment in vitro similar to that seen in the human body...
  59. Debra L Laskin; Fiscal Year: 2016
    ..We speculate that this is a key step leading to proliferation of type II cells and repair of damaged epithelium following ozone-induced injury...
  60. Screen for Small Molecule Regulators of Retinal Progenitor Epithelial Cell Phagoc
    CHARLES YOON HYUNG CHO; Fiscal Year: 2010
    ..Several mutations have been found to cause RP, most of them inducing a defect in the retinal pigment epithelium (RPE) or a breakdown of the photoreceptors outer segment disc membranes...
  61. Erik L Hewlett; Fiscal Year: 2015
    ..tract and is key in resisting bacterial clearance by neutrophils (PMN), yet its effects on the respiratory epithelium have not been studied...
  62. Bogi Andersen; Fiscal Year: 2016
    ..reveals the relationship between the clock, metabolism, cell proliferation and cancer in a rapidly proliferating epithelium, because it suggests that circadian regulation may contribute to the high incidence of skin cancer in humans, ..
  63. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..whether DRC of inflammation caused DNA damage is associated with development of pre- malignant lesions in lung epithelium. Therefore, we propose this study to test the hypothesis that DRC of inflammation caused DNA damage may predict ..
  64. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
    ..provided by applicant): Pheromones stimulate some olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE), but the transduction mechanism is poorly understood...
  65. IMMUNOREGULATION OF GUT EPITHELIUM TO ESCAPE PARASITISM
    GILBERT CASTRO; Fiscal Year: 1991
    ..interface between infective L1 larvae of Trichinella spiralis and the host at the level of the small intestinal epithelium, the parasite's habitat...
  66. ATP LINKED EFFECTORS OF NA+, K+ ATPASE AND CATARACTS
    MARGARET GARNER; Fiscal Year: 2001
    ..cataract lenses, were believed to result from the dysfunction of membrane Na+ transport systems of the lens epithelium. ATP hydrolysis by the Na, K-ATPase of the lens epithelium is altered in a majority of human cataract lenses...
  67. INTRAVAGINAL PRODUCTS EFFECT ON VAGINAL PHYSIOLOGY
    David Eschenbach; Fiscal Year: 1999
    ..microorganisms by producing a low pH and hydrogen peroxide, reducing the attachment of bacteria to the vaginal epithelium which reduces the ability of the bacteria to establish colonization, and an intact vaginal epithelium which ..
  68. Eph/Ephrin signaling in Taste Nerve Targeting
    MICHAEL WILLIAM ROCHLIN; Fiscal Year: 2010
    ..The discrete nature of taste papillae and the taste buds within their epithelium make it an excellent model for studying axon targeting mechanisms...
  69. Interactions of engineered nanomaterials with lung alveolar epithelium
    EDWARD DAVID CRANDALL; Fiscal Year: 2010
    ..to markedly increase, the mechanisms by which ENM injure and/or are transported into/across lung alveolar epithelium are not well known...
  70. NORMAL AND ABNORMAL UTERO-VAGINAL DEVELOPMENT
    Gerald Cunha; Fiscal Year: 1991
    ..Utilizing animal models, the role of epithelium in myometrial differentiation will be examined to determined whether only uterine epithelium can induce ..
  71. GASTRIC PRENEOPLASIA IN H FELIS INFECTED IL10 MICE
    Daniel Berg; Fiscal Year: 2002
    ..define the mechanisms by which chronic Helicobacter infection leads to the development of preneoplastic gastric epithelium, using a novel animal model, Helicobacter felis-infected interleukin 10-deficient mice (IL10-/-)...
  72. Tolerance to TLR Ligands in the Intestinal Epithelium
    Anatoly V Grishin; Fiscal Year: 2010
    The intestinal epithelium is continuously exposed to high concentrations of bacteria...
  73. MOLECULAR GENETICS OF INTESTINAL DEVELOPMENT
    Jeffrey Gordon; Fiscal Year: 1999
    The mouse intestinal epithelium represents a continuous development system and provides a unique mammalian model for examining how cellular proliferation, lineage allocation (commitment), and differentiation are interrelated...
  74. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2005
    ..the elucidation of regulatory mechanisms and pathways associated with macromolecule transport across alveolar epithelium. Preliminary studies on protein transport across primary cultured cell monolayers, which exhibit phenotypic and ..
  75. IN VITRO MODEL OF HUMAN VAGINAL EPITHELIUM
    Ann Stapleton; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's description): The human vaginal epithelium is located in a key anatomical location, between the external environment and protected sites in the upper genital tract, and forms a barrier to infecting ..