connective tissue


Summary: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.

Top Publications

  1. pmc Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
    Malea M Murphy
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Development 138:3625-37. 2011
  2. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  3. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012
  4. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
  5. ncbi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
  6. pmc An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
    Brian C Tieu
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 119:3637-51. 2009
  7. ncbi Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
  8. ncbi Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
  9. ncbi Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
    Efstathios Vassiliadis
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 16:426-33. 2011
  10. ncbi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011

Detail Information

Publications325 found, 100 shown here

  1. pmc Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
    Malea M Murphy
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
    Development 138:3625-37. 2011
    ..b>Connective tissue fibroblasts also are likely to play a role in regeneration, as connective tissue fibrosis is a hallmark of ..
  2. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  3. pmc Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
    Boris Hinz
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 180:1340-55. 2012 several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; ii) factors controlling the expression of α-smooth muscle actin, the most used marker of ..
  4. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
    ..Zinc (Zn) is an essential trace element and it is abundant in connective tissues, however biological roles of Zn and its transporters in those tissues and cells remain unknown...
  5. ncbi Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
    Nicolai Treiber
    Department of Dermatology and Allergic Diseases, University of Ulm, Maienweg 12, Ulm, Germany
    Aging Cell 10:239-54. 2011
    ..Its role in aging of the connective tissue has not yet been established, even though the incidence of aging-related disorders in connective tissue-rich ..
  6. pmc An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
    Brian C Tieu
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 119:3637-51. 2009
  7. ncbi Role of the adventitia in pulmonary vascular remodeling
    Kurt R Stenmark
    Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Physiology (Bethesda) 21:134-45. 2006
    ..The purpose of this review is to present the current evidence demonstrating that the adventitial fibroblast acts as a key regulator of pulmonary vascular function and structure from the "outside-in."..
  8. ncbi Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia
    Marc Schmidt
    Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
    J Biol Chem 279:8063-9. 2004
    ..with three antibodies directed against different epitopes of the protein consistently show cytoglobin in connective tissue fibroblasts as well as in hepatic stellate cells...
  9. ncbi Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
    Efstathios Vassiliadis
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 16:426-33. 2011
    ..The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis...
  10. ncbi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011
    ..The purpose of this article is to review the progress of TE technology, focusing on mesenchymal stem cells (MSC) as a cell source for artificial functional tissue...
  11. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009
    ..pathogenesis of chronic low back pain (LBP), there have been no previous studies quantitatively evaluating connective tissue structure in this condition...
  12. ncbi Adventitial progenitor cells contribute to arteriosclerosis
    Evelyn Torsney
    Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, SW17 0RE London, UK
    Trends Cardiovasc Med 15:64-8. 2005
    ..Thus, these cells may be a source of smooth muscle cells and might have implications for cellular, genetic, and tissue engineering approaches to vascular disease...
  13. pmc Extracellular matrix mechanics in lung parenchymal diseases
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Respir Physiol Neurobiol 163:33-43. 2008
    ..Finally, we speculate about the possibility of using targeted tissue engineering to optimize treatment of these two major lung diseases...
  14. ncbi Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling
    Boris Hinz
    Laboratory of Cell Biophysics, Swiss Federal Institute of Technology, Bâtiment SG AA B 143, CH 1015 Lausanne, Switzerland
    Thromb Haemost 90:993-1002. 2003
    ..modulation represents a crucial step in granulation tissue contraction and in the production of the connective tissue deformations typical of fibrocontractive diseases...
  15. pmc Connective tissue fibroblasts and Tcf4 regulate myogenesis
    Sam J Mathew
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Development 138:371-84. 2011
    Muscle and its connective tissue are intimately linked in the embryo and in the adult, suggesting that interactions between these tissues are crucial for their development...
  16. ncbi Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, D 52074 Aachen, Germany
    J Hepatol 47:699-710. 2007
    b>Connective tissue growth factor (CTGF/CCN2) has been implicated in the pathogenesis of hepatic fibrosis and suggested as a downstream mediator of the fibrogenic master cytokine TGF-beta.
  17. ncbi Pathologic changes in the pericoronal tissues of unerupted third molars
    S Rakprasitkul
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, 6 Yothi Street, Rajthevee, Bangkok 10400, Thailand
    Quintessence Int 32:633-8. 2001
    ..The purpose of this study was to determine whether the incidence of pathologic conditions affecting the pericoronal tissue of unerupted third molars justifies their routine removal...
  18. ncbi Pseudotumours associated with metal-on-metal hip resurfacings
    H Pandit
    Nuffield Orthopaedic Centre, Oxford, England
    J Bone Joint Surg Br 90:847-51. 2008
    ..We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause...
  19. ncbi Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont, Burlington, VT 05405, United States
    Med Hypotheses 68:74-80. 2007
    ..This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural ..
  20. ncbi Oral focal mucinosis: report of 15 cases and review of the literature
    Michael J Aldred
    Dorevitch Pathology, Heidelberg, Victoria, Australia
    Pathology 35:393-6. 2003
    ..To describe 15 cases of oral focal mucinosis (OFM) and compare these to previously reported cases...
  21. ncbi Changes in connective tissue in patients with pelvic organ prolapse--a review of the current literature
    M H Kerkhof
    Kennemer Gasthuis Haarlem, Haarlem, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 20:461-74. 2009
    ..In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level...
  22. ncbi Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms
    M D Huffman
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Surgery 128:429-38. 2000
    Abdominal aortic aneurysms (AAAs) involve an unfavorable balance between the destruction and the repair of connective tissue proteins...
  23. pmc Chondroitin sulphate inhibits connective tissue mast cells
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, MA 02111, USA
    Br J Pharmacol 131:1039-49. 2000
    ..3. Immunologic stimulation of histamine secretion from rat connective tissue mast cells (CTMC) was also inhibited, but this effect was weaker in umbilical cord-derived human mast cells ..
  24. pmc Muscle degeneration in neuraminidase 1-deficient mice results from infiltration of the muscle fibers by expanded connective tissue
    Edmar Zanoteli
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochim Biophys Acta 1802:659-72. 2010
    ..Muscle fibers located adjacent to the expanded connective tissue underwent extensive invagination of their sarcolemma, which resulted in the infiltration of the fibers by ..
  25. ncbi Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy
    A Mobasheri
    Division of Veterinary Medicine, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom
    Histol Histopathol 24:347-66. 2009
  26. pmc Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans
    H Langberg
    Sports Medicine Research Unit, Department of Rheumatology H and Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
    J Physiol 521:299-306. 1999
    ..This suggests an adaptation to acute physical loading also in non-bone-related collagen in humans...
  27. ncbi Subepithelial connective tissue grafts in the treatment of multiple recession-type defects
    Luiz Armando Chambrone
    Discipline of Periodontics, Faculty of Dentistry, Methodist University of Sao Paulo, Sao Bernardo do Campo, Brazil
    J Periodontol 77:909-16. 2006
    ..The objective of this study was to evaluate the results obtained with a connective tissue graft placed under a coronally advanced flap for the treatment of multiple gingival recessions.
  28. pmc Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma
    Victor H Hu
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 80:121-30. 2012
    ..This study supports the possibility that the immunofibrogenic response in scarring trachoma is partly stimulated by nonchlamydial bacterial infection, which is characterized by the expression of innate factors...
  29. ncbi Mutable collagenous tissue: overview and biotechnological perspective
    I C Wilkie
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 OBA, Scotland, UK
    Prog Mol Subcell Biol 39:221-50. 2005
    ..that MCT could be a source of, or inspiration for, (1) new pharmacological agents and strategies designed to manipulate therapeutically connective tissue mechanical properties and (2) new composite materials with biomedical applications.
  30. ncbi Use of platelet gel with connective tissue grafts for root coverage: a randomized-controlled trial
    Huseyin Gencay Keceli
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Clin Periodontol 35:255-62. 2008
    ..Platelet-rich plasma (PRP) was speculated to be a promoter of periodontal regeneration. There are only a few clinical comparative studies using PRP in the treatment of gingival recession...
  31. ncbi Structural and mechanical architecture of the intestinal villi and crypts in the rat intestine: integrative reevaluation from ultrastructural analysis
    Yasue Hosoyamada
    Department of Nutrition, Chiba College of Health Science, 2 10 1 Wakaba, Mihama ku, Chiba shi, Chiba, 261 0014, Japan
    Anat Embryol (Berl) 210:1-12. 2005
  32. pmc Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling
    Brian C Tieu
    Department of Biochemistry, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Vasc Res 48:261-72. 2011
    ..Our objective was to explore the contribution of these cells to angiotensin II (Ang II)-induced aortic inflammation and adventitial expansion...
  33. ncbi A histologic evaluation of various stages of palatal healing following subepithelial connective tissue grafting procedures: a comparison of eight cases
    Kristi M Soileau
    Department of Oral and Maxillofacial Pathology, Louisiana State University School of Dentistry, New Orleans, LA 70115, USA
    J Periodontol 77:1267-73. 2006
    ..The purpose of this study was to determine whether the length of time between a first procurement and a second would have any bearing on the quality of tissue available for recipient sites...
  34. ncbi Peptides controlling stifness of connective tissue in sea cucumbers
    R Birenheide
    Basic Biology, Faculty of Bioscience and Biotechnology, Tokyo Institue of Technology, Japan
    Biol Bull 194:253-9. 1998
    ..The body wall dermis of sea cucumbers consists of catch connective tissue that is characterized by quick and drastic stiffness changes under nervous control...
  35. pmc Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions
    Hongli Yang
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:345-63. 2011
    ..that monkey ONH connective tissues become hypercompliant in early experimental glaucoma (EEG), by using 3-D histomorphometric reconstructions, and to expand the characterization of EEG connective tissue deformation to nine EEG eyes.
  36. ncbi Ontogenetic decline of regenerative ability and the stimulation of human regeneration
    David M Gardiner
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, California 92697, USA
    Rejuvenation Res 8:141-53. 2005
    ..A second lesson is that connective tissue fibroblasts control regeneration, and that the unique regenerative ability of salamanders (the first step of ..
  37. ncbi Connective tissue configuration in the human liver hilar region with special reference to the liver capsule and vascular sheath
    Shogo Hayashi
    Aichi Medical University Education Center AMEC, 21 Yazako Karimata, Nagakute, Aichi, 480 1195, Japan
    J Hepatobiliary Pancreat Surg 15:640-7. 2008
  38. ncbi Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration
    Mounir J Haurani
    Department of General Surgery, Hypertension and Vascular Research Division, Room 7044, E and R Building, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 52:143-9. 2008
    ..05). Our data suggest that Nox4 promotes Ang II-induced myofibroblast migration via an H(2)O(2)-dependent pathway. The data also suggest that Nox4 causes feedback inhibition of its own expression in adventitial myofibroblasts...
  39. ncbi Immunomodulation of TGF-beta 1 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy
    Francesca Andreetta
    Department of Neuroimmunology and Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Neuroimmunol 175:77-86. 2006
    Irreversible connective tissue proliferation in muscle is a pathological hallmark of Duchenne muscular dystrophy (DMD), a genetic degenerative muscle disease due to lack of the sarcolemmal protein dystrophin...
  40. ncbi A comparative study of the biocompatibility of three root-end filling materials in rat connective tissue
    Shahriar Shahi
    Department of Endodontics, Tabriz Faculty of Dentistry, Azarbaidjan Shargi, Iran
    J Endod 32:776-80. 2006
    The purpose of this study was to compare the biocompatibility of amalgam, gray MTA and white MTA in the connective tissue of rats. We used 45 Sprague-Dawley rats in this study. The rats were divided into three groups...
  41. ncbi Connective tissue structure of the tree shrew optic nerve and associated ageing changes
    Julie Albon
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 48:2134-44. 2007
    ..To identify the structure and composition of the tree shrew optic nerve to determine its potential as a model for glaucoma...
  42. ncbi Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy
    Guilian Sun
    Department of Pediatrics, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Sci 267:48-56. 2008
    ..In the present study, the immunolocalization and mRNA expression of connective tissue growth factor (CTGF) in muscles from normal and dystrophic human muscles were examined with the goal of ..
  43. ncbi Connective tissue growth factor in drug-induced gingival overgrowth
    M I Uzel
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, MA 02118, USA
    J Periodontol 72:921-31. 2001
    ..This study assesses for the presence and localization of connective tissue growth factor (CTGF) in drug-induced gingival overgrowth tissues...
  44. ncbi Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes
    Hannah L Bader
    Universite de Lyon, Universite Lyon 1, France
    Matrix Biol 28:32-43. 2009
    ..exhibited a much broader expression pattern than previously thought: it was ubiquitously expressed in the connective tissue sheaths (fascia) that encase the tissues and organs of the body...
  45. ncbi Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
    M A Rossi
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Hypertens 16:1031-41. 1998
    To investigate pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans.
  46. ncbi Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice
    Denise M Inman
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    J Comp Neurol 462:431-49. 2003
    ..a unique wound healing response following spinal cord injury in which the lesion site fills in with a connective tissue matrix...
  47. ncbi Reactions of connective tissue to mineral trioxide aggregate and amalgam
    Mehmet Yaltirik
    Faculty of Dentistry, Department of Oral Surgery and Medicine, Istanbul University, Turkey
    J Endod 30:95-9. 2004
    The purpose of this study was to evaluate the subcutaneous connective tissue reactions to ProRoot, mineral trioxide aggregate (MTA; Dentsply), and Oralloy, high-copper amalgam (Coltene)...
  48. ncbi The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice
    Michael P W Moos
    The Institute for Vascular Medicine, Friedrich Schiller University of Jena, Germany
    Arterioscler Thromb Vasc Biol 25:2386-91. 2005
    ..Cells of adaptive immunity have been implicated in atherogenesis. Though substantial information is available on immune cells in atherosclerotic lesions of the lamina intima, cells in the lamina adventitia have received less attention...
  49. ncbi Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    Acupuncture needle manipulation has been previously shown to result in measurable changes in connective tissue architecture in animal experiments...
  50. pmc The adventitia: a dynamic interface containing resident progenitor cells
    Mark W Majesky
    Seattle Children s Research Institute, Departments of Pediatric, Center for Cardiovascular Biology, and the Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98101, USA
    Arterioscler Thromb Vasc Biol 31:1530-9. 2011
    ..views of the tunica adventitia as a poorly organized layer of vessel wall composed of fibroblasts, connective tissue, and perivascular nerves are undergoing revision...
  51. ncbi Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?
    Mounir J Haurani
    Henry Ford Hospital, Detroit, Department of General Surgery, MI 48202 2689, USA
    Cardiovasc Res 75:679-89. 2007
    ..We will also survey other signaling pathways involving adventitial NAD(P)H oxidase ultimately leading to changes in vascular phenotype...
  52. ncbi No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
    Benjamin F Miller
    Institute of Sports Medicine, Copenhagen
    Am J Physiol Endocrinol Metab 290:E163-E168. 2006
    ..Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women...
  53. pmc Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-))
    Jennifer Larusso
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Invest Dermatol 129:1388-94. 2009
    Pseudoxanthoma elasticum (PXE) is an autosomal recessive multisystem disorder characterized by ectopic connective tissue mineralization, with clinical manifestations primarily in the skin, eyes, and cardiovascular system...
  54. pmc Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes
    Michael D Roberts
    Ocular Biomechanics, Legacy Health System, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:295-307. 2010
    ..To investigate the biomechanical response to IOP elevation of normal monkey eyes using eye-specific, three-dimensional (3-D) finite element (FE) models of the ONH that incorporate lamina cribrosa (LC) microarchitectural information...
  55. ncbi Connective tissue metabolism and gingival overgrowth
    P C Trackman
    Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Division of Oral Biology, Boston, MA 02118, USA
    Crit Rev Oral Biol Med 15:165-75. 2004
  56. ncbi Serum collagen type VI and XIV and hyaluronic acid as early indicators for altered connective tissue turnover in alcoholic liver disease
    F Stickel
    I. Department of Medicine, University of Erlangen-Nurnberg, Erlangen, Germany
    Dig Dis Sci 46:2025-32. 2001
    ..The correlation between procollagen-III-N-propeptide and TGF-beta1 emphasizes its role in hepatic fibrogenesis...
  57. ncbi Influence of laser photobiomodulation upon connective tissue remodeling during wound healing
    Alena P Medrado
    Laboratory of Experimental Pathology, Oswaldo Cruz Foundation, Rua Waldemar Falcão, 121, Salvador, Bahia 40 296 710, Brazil
    J Photochem Photobiol B 92:144-52. 2008
    ..Thus, laser photobiomodulation was able to induce several modifications during the cutaneous healing process, especially in favoring newly-formed collagen fibers to be better organized and compactedly disposed...
  58. ncbi Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
    H M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    FASEB J 15:2275-82. 2001
    ..We hypothesize that 1) needle grasp is due to mechanical coupling between the needle and connective tissue with winding of tissue around the needle during needle rotation and 2) needle manipulation transmits a ..
  59. ncbi Dermal connective tissue metabolism in photoageing
    Y Miyachi
    Department of Dermatology, Gunma University School of Medicine, Japan
    Australas J Dermatol 39:19-23. 1998
    ..The connective tissue of the skin is composed mainly of collagen, glycosaminoglycans and elastin and, thus, alterations of these ..
  60. pmc Viscoelastic properties of bovine orbital connective tissue and fat: constitutive models
    Lawrence Yoo
    Department of Ophthalmology, Jules Stein Eye Institute, University of California, 100 Stein Plaza, UCLA, Los Angeles, CA 90095 7002, USA
    Biomech Model Mechanobiol 10:901-14. 2011
    Reported mechanical properties of orbital connective tissue and fat have been too sparse to model strain-stress relationships underlying biomechanical interactions in strabismus...
  61. ncbi [The role of adventitia in atherosclerosis]
    Zi Yi Liu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    Sheng Li Ke Xue Jin Zhan 41:177-82. 2010
    ..Thus the current review will focus on most advanced studies related to the role of adventitial fibroblasts in some cardiovascular diseases such as atherosclerosis...
  62. ncbi Ultrastructural connective tissue aberrations in patients with intracranial aneurysms
    Caspar Grond-Ginsbach
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:2192-6. 2002
    An unknown connective tissue defect might predispose for the development and rupture of intracranial aneurysms in some patients...
  63. ncbi Angiotensin II and connective tissue: homeostasis and reciprocal regulation
    K T Weber
    Division of Cardiology, University of Missouri Health Sciences Center, Columbia, USA
    Regul Pept 82:1-17. 1999
    ..angiotensin converting enzyme (ACE) and AngII receptors, are expressed by mesenchymal cells responsible for connective tissue turnover. ACE inhibition or AT1 receptor antagonism attenuate the formation of these connective tissues...
  64. ncbi Perivascular space: possible anatomical substrate for the meridian
    Wentao Ma
    Department of Analysis Measurement Science, School of Life Sciences, Wuhan University, Wuhan 430 072, People s Republic of China
    J Altern Complement Med 9:851-9. 2003
    ..On the other hand, perivascular space (PVS) has been demonstrated to be a body fluid pathway in addition to blood vessels and lymphatics in some mammalian tissues, such as brain, thymus, and lung...
  65. ncbi Relationship of acupuncture points and meridians to connective tissue planes
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Anat Rec 269:257-65. 2002
    ..of acupuncture points and meridians can be viewed as a representation of the network formed by interstitial connective tissue. This hypothesis is supported by ultrasound images showing connective tissue cleavage planes at acupuncture ..
  66. pmc Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue
    Zeeshan H Syedain
    Departments of Chemical Engineering and Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 105:6537-42. 2008
    ..constant CD. These results suggest cell adaptation may limit conventional strategies of stretching with constant strain amplitude and that new approaches might optimize bioreactor operation...
  67. pmc The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicus
    Maurice R Elphick
    Queen Mary University of London, School of Biological and Chemical Sciences, London, United Kingdom
    PLoS ONE 7:e44492. 2012
    ..NGIWYamide was originally discovered as a muscle contractant, but it also causes stiffening of mutable connective tissue in the body wall of A...
  68. ncbi Estimation of Young's modulus and Poisson's ratio of soft tissue from indentation using two different-sized indentors: finite element analysis of the finite deformation effect
    A P C Choi
    Rehabilitation Engineering Centre, Kowloon Polytechnic University, Kowloon, China
    Med Biol Eng Comput 43:258-64. 2005
    ..After the finite deformation effect of indentation was considered, the error of the calculated Young's modulus could be controlled within 5% (a/h = 1) and 2% (a/h = 2) for deformation up to 10%...
  69. ncbi Treatment of gingival recession: comparison of two techniques of subepithelial connective tissue graft
    Tolga F Tozum
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Periodontol 76:1842-8. 2005
    ..This clinical study was conducted to examine the coverage of gingival recession defects, where two different subepithelial connective tissue graft (SCTG) techniques (Langer and Langer and modified tunnel) were used.
  70. pmc Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma
    Michael D Roberts
    Ocular Biomechanics Laboratory, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 50:681-90. 2009
    To characterize the trabeculated connective tissue microarchitecture of the lamina cribrosa (LC) in terms of total connective tissue volume (CTV), connective tissue volume fraction (CTVF), predominant beam orientation, and material ..
  71. ncbi Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells
    Ayuko Hoshino
    Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    Biochem Biophys Res Commun 368:305-10. 2008
    ..These findings demonstrate that human vascular adventitia contains MPCs, and that hVAFs may be an ideal source for further experiments on stem cell biology and tissue engineering...
  72. ncbi Leukotriene formation by mouse connective tissue mast cells
    B A Jakschik
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110
    Eicosanoids 5:39-43. 1992
    ..Western blot analysis confirmed the presence of 5-lipoxygenase in connective tissue mast cells...
  73. ncbi Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling
    C D Jordan
    Department of Pathology, University of Washington, USA
    J Musculoskelet Neuronal Interact 6:366-7. 2006
  74. ncbi Single-tooth replacement by immediate implant and connective tissue graft: a 1-9-year clinical evaluation
    Andrea E Bianchi
    Department of Periodontology and Implantology, Istituto Stomatologico Italiano, Milan, Italy
    Clin Oral Implants Res 15:269-77. 2004
    ..the long-lasting efficacy of a combined surgical protocol, using immediate implant and subepithelial connective tissue graft for single-tooth replacement...
  75. pmc CAUDLES-EF: carotid automated ultrasound double line extraction system using edge flow
    Filippo Molinari
    Biolab Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129, Torino, Italy
    J Digit Imaging 24:1059-77. 2011
    ..Regarding the Figure of Merit (FoM), CALEXia and CULEXsa showed the values of 84.7% and 91.5%, respectively, while our new approach, CAUDLES-EF, performed the best at 94.8%, showing a good improvement compared to previous methods...
  76. ncbi Tissue response to a new methacrylate-based root canal sealer: preliminary observations in the subcutaneous connective tissue of rats
    Osvaldo Zmener
    Department of Adult Dental Care, Section of Endodontics, Faculty of Odontology, University of Buenos Aires, Republica Argentina
    J Endod 30:348-51. 2004
    ..Silicone tubes filled with EndoRez, a methacrylate-based root canal sealer, were implanted in the subcutaneous connective tissue of the rat...
  77. ncbi Endothelin-1 expression in vascular adventitial fibroblasts
    Sheng Jun An
    Dept of Community Health Sciences, Faculty of Applied Health Sciences, Brock Univ, St Catharines, ON, Canada L2S 3Y6
    Am J Physiol Heart Circ Physiol 290:H700-8. 2006
    ..The results demonstrate that vascular adventitial fibroblasts are able to synthesize and release ET-1 in response to ANG II...
  78. ncbi Initial characterization of the microenvironment that regulates connective tissue degradation in amniochorion during normal human labor
    Guadalupe Estrada-Gutierrez
    Research Direction, Instituto Nacional de Perinatologia, Mexico City, Mexico
    Matrix Biol 24:306-12. 2005
    ..Initial characterization of the effect of different blood compartments on connective tissue degradation in amniochorion during human labor was explored...
  79. ncbi An ultrastructural study of connective tissue in mollusc integument: II. Gastropoda
    A Bairati
    Dipartimento di Fisiologia e Biochimica Generali, Sezione di Istologia e Anatomia Umana, Universita degli Studi di Milano, Italy
    Tissue Cell 33:426-38. 2001
    We studied the ultrastructure of the subepidermal connective tissue (SEC) in different zones of the integument in terrestrial, marine and freshwater gastropods (eight species)...
  80. ncbi Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1
    Darcey Klaahsen
    Department of Human Nutrition, Kansas State University, Manhattan, KS 66506, USA
    J Nutr Biochem 18:719-26. 2007
    ..The results of this study merit the further investigation of the role of reactive oxidative species with regard to Nfkappab1 in the copper deficient rat heart...
  81. ncbi Epimuscular myofascial force transmission between antagonistic and synergistic muscles can explain movement limitation in spastic paresis
    Peter A Huijing
    Instituut voor Fundamentele en Klinische Bewegingswetenschappen, Faculteit Bewegingswetenschappen, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Electromyogr Kinesiol 17:708-24. 2007
  82. ncbi Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia
    Pattaratida Sa-nguanmoo
    Center of Excellence in Viral Hepatitis Research, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University
    J Med Assoc Thai 90:251-7. 2007
    b>Connective tissue growth factor (CTGF) has been proposed to play a key role in the pathogenesis of hepatic fibrosis in biliary atresia (BA)...
  83. ncbi The connective tissue and glial framework in the optic nerve head of the normal human eye: light and scanning electron microscopic studies
    Tokuhide Oyama
    Division of Microscopic Anatomy and Bio imaging, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Histol Cytol 69:341-56. 2006
    The arrangement of connective tissue components (i.e...
  84. ncbi Zosteriform connective tissue nevus: a case report
    Shih Wei Yeh
    Department of Dermatology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Int J Dermatol 42:720-2. 2003
    Because of its distinctive clinical features and histopathological characteristics, zosteriform connective tissue nevus is considered a separate entity from other connective tissue nevi...
  85. ncbi Water transport and IIF parameters for a connective tissue equivalent
    Saravana Kumar Balasubramanian
    Department of Mechanical Engineering, University of Minnesota, 111 Church Street SE, Minneapolis, MN 55455, USA
    Cryobiology 52:62-73. 2006
    ..The observed biophysics seems to indicate that cell-cell and cell-matrix interactions play a major role in ice propagation in TEs...
  86. ncbi Short and long-term results of connective tissue manipulation and combined ultrasound therapy in patients with fibromyalgia
    Ilkim Citak-Karakaya
    Mugla University, Mugla School of Health Sciences, Mugla, Turkey
    J Manipulative Physiol Ther 29:524-8. 2006
    The aim of the study was to evaluate the short-term and 1-year follow-up results of connective tissue manipulation and combined ultrasound (US) therapy (US and high-voltage pulsed galvanic stimulation) in terms of pain, complaint of ..
  87. pmc Light and scanning electron microscopic study on the lingual papillae and their connective tissue cores of the Cape hyrax Procavia capensis
    Ken Yoshimura
    Department of Anatomy, Faculty of Life Dentistry, The Nippon Dental University at Niigata, Niigata, Japan
    J Anat 213:573-82. 2008
    We examined the epithelial surface and connective tissue cores (CTCs) of each lingual papilla on the Paenungulata, Cape hyrax (Procavia capensis), by scanning electron microscopy and light microscopy...
  88. ncbi A novel stiffening factor inducing the stiffest state of holothurian catch connective tissue
    Akira Yamada
    Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, Kobe, Hyogo 651 2492, Japan
    J Exp Biol 213:3416-22. 2010
    The dermis of sea cucumbers is a catch connective tissue or mutable collagenous tissue that shows large changes in stiffness...
  89. ncbi PLGA nanofiber-coated silk microfibrous scaffold for connective tissue engineering
    Sambit Sahoo
    NUS Tissue Engineering Program, National University of Singapore, Singapore
    J Biomed Mater Res B Appl Biomater 95:19-28. 2010
    ..Although PLGA-based hybrid scaffolds have earlier been proposed for dense connective tissue engineering, rapid biodegradation of PLGA was a drawback...
  90. ncbi Basaloid/follicular hyperplasia overlying connective tissue/mesenchymal hamartomas simulating basal cell carcinomas
    M E Stashower
    Department of Dermatology, National Naval Medical Center, Bethesda, Maryland, USA
    J Am Acad Dermatol 45:886-91. 2001
    ..antibodies, which may suggest differences in pathogenesis, were different in basaloid hyperplasia overlying connective tissue/mesenchymal hamartomas and BCC...
  91. ncbi Reaction of rat connective tissue to implanted dentin tubes filled with a white mineral trioxide aggregate
    Roberto Holland
    Department of Restorative Dentistry, Faculty of Dentistry of Aracatuba, UNESP, Aracatuba, SP, Brazil
    Braz Dent J 13:23-6. 2002
    The purpose of this paper was to study the reaction of rat subcutaneous connective tissue to the implantation of dentin tubes filled with white mineral trioxide aggregate (MTA), a material that will be marketed...
  92. ncbi The fine connective tissue architecture of the human ligamentum nuchae
    G M Johnson
    Department of Anatomy and Structural Biology, University of Otago School of Physiotherapy, Dunedin, New Zealand
    Spine (Phila Pa 1976) 25:5-9. 2000
    ..An anatomic study of the posterior midline structures of the cervical spine was performed using a new sheet-plastination (E12) technique in conjunction with gross anatomic dissection...
  93. pmc Force transmission between synergistic skeletal muscles through connective tissue linkages
    Huub Maas
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
    J Biomed Biotechnol 2010:575672. 2010
    ..Future studies are needed to investigate the importance of intermuscular force transmission during movement in health and disease...
  94. ncbi Diagnostic value of serum markers of connective tissue turnover for predicting histological staging and grading in patients with chronic hepatitis C
    Y Murawaki
    Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan
    J Gastroenterol 36:399-406. 2001
    ..CONCLUSIONS: These serum fibrotic markers, especially the serum HA test, would be clinically useful for assessing staging and grading in patients with chronic hepatitis C...
  95. ncbi Comparison of 2 techniques of subepithelial connective tissue graft in the treatment of gingival recessions
    G Cordioli
    Department of Periodontology, University of Padova, Institute of Clinical Dentistry, Italy
    J Periodontol 72:1470-6. 2001
    BACKGROUND: The clinical outcome of connective tissue grafts in the treatment of gingival recessions has been documented in numerous studies...
  96. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
    The visco-elastic behavior of connective tissue is generally attributed to the material properties of the extracellular matrix rather than cellular activity...
  97. ncbi Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms
    Federico E Parodi
    Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Vasc Surg 20:360-8. 2006
    ..The possibility that dietary ingestion of curcumin may have a beneficial effect in degenerative aortic aneurysms warrants further consideration...
  98. pmc Application of WGA lectin staining for visualization of the connective tissue in skeletal muscle, bone, and ligament/tendon studies
    Tatiana Y Kostrominova
    Department of Anatomy and Cell Biology, Indiana University School of Medicine Northwest, Gary, Indiana 46409 1008
    Microsc Res Tech 74:18-22. 2011
    ..Often in skeletal muscle research, immunostaining with antibodies against connective tissue or plasma membrane proteins (collagen 1, laminin, and caveolin 3) are used for this purpose...
  99. ncbi The echinoderm collagen fibril: a hero in the connective tissue research of the 1990s
    Greg Szulgit
    Department of Biology, McDaniel College, 2 College Hill, Westminster, MD 21157, USA
    Bioessays 29:645-53. 2007
    ..This information will be fundamental in understanding what holds collagenous tissues together at the fibrillar level, and could have important implications for people with Ehlers-Danlos syndrome...
  100. ncbi Contractile and connective tissue protein content of human skeletal muscle: effects of 35 and 90 days of simulated microgravity and exercise countermeasures
    Jacob M Haus
    Human Performance Laboratory, Ball State Univ, Muncie, IN 47306, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1722-7. 2007
    ..muscles are able to maintain the concentrations of the general protein pools and the main contractile and connective tissue elements...
  101. ncbi Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils
    L Y Sakai
    Shriners Hospital for Crippled Children, Portland, Oregon 97201
    J Biol Chem 266:14763-70. 1991
    Fibrillin, a connective tissue macromolecule (Mr = 350,000) which is normally insoluble in its tissue form, has been purified from the medium of human skin fibroblast and ligament cells in culture...

Research Grants108 found, 100 shown here

  1. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..Cytokines and growth factors such as transforming growth factor (TGF-Beta) and connective tissue growth factor (CTGF) activate fibroblasts and induce their differentiation to myofibroblasts, leading to ..
  2. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..These chemokines correlate with disease activity in other connective tissue disease...
  3. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
  4. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..This proposal seeks to understand the role of the HIF-1a and mitofusin in PAH and develop therapies (inhibition of HIF-1 a and supplementation of mitofusin-2) to restore mitochondrial form and function and cure PAH. ..
  5. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..Our combined expertise in the physiology of hypertension, connective tissue biochemistry and cardiovascular histomorphology place us in a unique position to pursue these directions of ..
  6. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..The causes of some of the ILDs are known, including those associated with connective tissue diseases such as systemic sclerosis (SSc, or scleroderma)...
  7. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010 the role of collagen II splicing in skeletal development is an important step forward in the field of connective tissue biology...
  8. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..The underlying pathology is diverse and predisposing factors include aortic aneurysms and diseases of the connective tissue. This is a life-threatening event, especially if the dissection is located in the ascending part of the ..
  9. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..that is coupled with myofibroblastic differentiation;and (ii) expression of the matricellular proteins connective tissue growth factor (CTGF), SPARC and periostin predicts BPD development. 2...
  10. International Symposium on Proline Metabolism and Human Health
    Donald F Becker; Fiscal Year: 2010
    ..having an important impact on bioenergetics, cellular redox control, apoptosis, cancer, schizophrenia, and connective tissue development...
    Devendra K Agrawal; Fiscal Year: 2013
    ..The proposed studies will provide conceptual support of our hypothesis and position us to translate our investigation into a clinical study in obese patients with coronary artery disease. ..
  12. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay E Reeder; Fiscal Year: 2010
    ..The condition, which seems to manifest as defects in the supporting connective tissue of the pelvic organs, adversely affects quality of life and is a major health issue for women...
  13. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
    ..the urokinase-type plasminogen activator receptor (uPAR) in the regulation of fibronectin matrix assembly in connective tissue cells...
  14. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ..In the pancreas, connective tissue growth factor (CTGF), a secreted protein in the CCN family, is expressed in embryonic beta cells and ..
  15. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..AMP peptide treatment protected the surface epithelium and connective tissue of the mouse tongue, and delayed the appearance and reduced the extent of ulcer formation in the buccal ..
    Gary W Conrad; Fiscal Year: 2012
    ..The long-range goal of the proposed research is to understand and to learn to repair the connective tissue of the cornea of the eye, based upon lessons learned from studying the differentiation of the connective ..
  17. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..The key criteria for regeneration will be restoration of connective tissue architecture, including the formation of functional elastic fibers and the initiation of hair follicle ..
  18. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..and imaging of arteries located deep in the body, such as the aorta, can be difficult due to the presence of connective tissue and fat...
  19. Immunoglobulin Activation of Fibroblasts
    Terry J Smith; Fiscal Year: 2012
    ..GD is also associated with the inflammation, accumulation of hyaluronan (HA), and remodeling of orbital connective tissue. This process is known as thyroid-associated ophthalmopathy (TAO) for which no effective treatment currently ..
  20. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stretching of soft tissue (connective tissue and muscle) is an important component of manual (e.g. massage) and movement-based (e.g...
  21. Regenerative Adjuvant Therapy for Stress Urinary Incontinence
    Margot S Damaser; Fiscal Year: 2011
    ..injuries since the maternal injuries of childbirth are similarly diffuse and involve nerves, muscles, connective tissue by a variety of mechanisms including direct trauma, ischemia, stretch, and avulsion...
  22. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    ..abstract_text> ..
  23. TGF-Beta in Intimal Hyperplasia after Vascular Bypass
    K Craig Kent; Fiscal Year: 2013
    ..through Smad3, appears to produce adaptive remodeling or arterial enlargement, mediated through the protein connective tissue growth factor (CTGF). These novel findings have generated three hypotheses...
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..Cell culture studies, animal experiments, and recent clinica trials strongly indicate that connective tissue growth factor (CTGF) is the dominant scar-inducing growth factor in the cornea and in other tissues, ..
  25. Development of Adult Pluripotent Very Small Embryonic Like (VSEL) Stem Cells to T
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Scleroderma is an autoimmune, connective tissue disorder which causes fibrosis of the skin and internal organs. In the skin, there is overproduction of extracellular matrix, and type 1 and 3 collagen...
  26. Cthrc1 function as a novel TGF-beta antagonist in the vasculature
    Volkhard Lindner; Fiscal Year: 2013
    ..With its ability to inhibit collagen production, Cthrc1 could be very suitable for the development of future antifibrotic therapies. ..
  27. Mechanisms of oval cell activation and differentiation
    Bryon E Petersen; Fiscal Year: 2013
    ..Previous experiments have implicated connective tissue growth factor (CTGF), Notch-1, Wnt1, Somatostatin (SST), insulin-like growth factor binding protein 3 (..
  28. Novel Therapies and Biomarkers for the Mucopolysaccharidoses
    CALOGERA MARIA SIMONARO; Fiscal Year: 2013
    The Mucopolysaccharidoses (MPS) are inherited, connective tissue disorders that result from the deficient activities of specific lysosomal enzymes required for glycosaminoglycan (GAG) degradation...
    Francis J Castellino; Fiscal Year: 2013
    ..microenvironment employed by GAS to catalyze degradation of fibrin, the extracellular matrix, and/or connective tissue, which then assists the spread of the bacteria...
  30. 2013 Elastin, Elastic Fibers &Microfibrils Gordon Research Conference &Gordon R
    Zsolt Urban; Fiscal Year: 2013, as well as with new and improved diagnostic and therapeutic strategies for acquired and genetic connective tissue disorders originating from derailed functions of the elastic fiber/microfibril system...
  31. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    ..Vascular endothelial growth factor, platelet derived growth factor, connective tissue growth factor, and transforming growth factor beta are among hundreds of potentially regenerative factors ..
  32. Connective Tissue Mechanotransduction
    Helene M Langevin; Fiscal Year: 2012 poorly understood, with the majority of research so far being on muscle, with comparatively little on connective tissue. In our previous grant, we demonstrated a novel, dynamic response of connective tissue fibroblasts to tissue ..
  33. Thrombospondins and other matricellular proteins in tissue organization and homeo
    Joanne E Murphy Ullrich; Fiscal Year: 2010
    ..extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix)...
  34. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ..ranging in severity from the prevention of steroid-induced osteoporosis in ambulatory children affected with connective tissue, gastrointestinal and pulmonary diseases, to prevention of bone loss in children with hypercalciuria...
  35. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..individuals with RDEB with the idea that our findings may have broad implications for understanding other connective tissue extracellular matrix diseases...
  36. Assessing the Impact of Osteogenesis Imperfecta on Non-Skeletal Systems
    Laura Tosi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Osteogenesis imperfecta (OI) is a rare, heterogeneous disease of connective tissue that affects about 30,000 persons in the United States...
  37. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..cells) to migrate into the TGF2-rich wound bed, because these cells must move into the wound to deposit new connective tissue materials and build new blood vessels (remodeling)...
  38. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ..We hypothesize further that heritable connective tissue disorders that commonly lead to aneurysms of, and dissections in, the aortic root or ascending aorta also ..
  39. Microfibril Fragments: Biomarkers of Aortic Disease
    Lynn Y Sakai; Fiscal Year: 2010
    ..Assays to measure other connective tissue protein fragments (e.g...
  40. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..are being investigated for treatment of cardiovascular disorders (stroke, myocardial infarction), diabetes, connective tissue disorders (cartilage defects, osteonecrosis, limb ischemia), chronic obstructive pulmonary disease, nervous ..
  41. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Thomas Doetschman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cardiac valve thickening is a major cardiovascular manifestation of connective tissue disorders (e.g., Marfan syndrome (MFS) and Ehlers-Danlos syndrome (EDS)), and non-syndromic valvular diseases...
  42. Cardiac Dystrophy: Cellular Mechanisms
    NATALIA V SHIROKOVA; Fiscal Year: 2013
    ..The pathoanatomic basis for the loss of function is mainly the replacement of myocardium by connective tissue and fat (fibrosis)...
  43. Developing A Novel Therapy for Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2013
    ..such as VEGF, tumor necrosis factor-alpha (TNF-[unreadable]), intercellular adhesion molecule-1 (ICAM-1), connective tissue growth factor (CTGF), fibronectin (FN), and Cox-2...
  44. Multi-Ethnic Study of Autoimmunity and Cardiovascular Disease
    Darcy S Majka; Fiscal Year: 2013 a well established association between clinically apparent coronary heart disease (CHD) and autoimmune connective tissue diseases (CTD) including rheumatoid arthritis and lupus, but the exact mechanism is not established...
  45. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..A. actinomycetemcomitans is found in the connective tissue of the periodontium and in close association with collagen fibers in infected tissues...
  46. Genetic Regulation of B Lymphocyte Aortic Homing and Atheroprotection
    Coleen A McNamara; Fiscal Year: 2013
    ..Results may not only identify, original and unconventional risk markers, but may also lay the groundwork for bold and creative approaches to bolster immune protection from atherosclerosis in humans. ..
  47. Regulation and function of Cyr61 in hyperoxia induced acute lung injury
    Yang Jin; Fiscal Year: 2010
    ..that are extremely cysteine-rich and was named after its first three members (cysteine-rich 61 (Cyr61), connective tissue growth factor (CTGF) and nephroblastoma overexpressed (NOV)...
    Sergio A Jimenez; Fiscal Year: 2010
    ..SSc) is a disease of unknown etiology characterized by the excessive deposition of collagen and other connective tissue components in skin and multiple internal organs, prominent and often severe alterations in the ..
  49. Mechanisms of Metal Ion Regulation in Human Cells
    Svetlana Lutsenko; Fiscal Year: 2013
    ..Copper is an essential nutrient required for embryonic development, connective tissue formation, myelination of neurons, detoxification of radicals, and many other physiological processes...
  50. Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysis
    Julie M Barkmeier-Kraemer; Fiscal Year: 2013
    ..These findings support Sunderland's theory that connective tissue patterns within peripheral nerves may develop in response to environmental forces to which the nerve is ..
  51. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol A Otey; Fiscal Year: 2010
    ..adhesion between neighboring cells, and generating connections between cells and their underlying connective tissue. Palladin is a recently described protein that plays a key role in organizing these actin filament arrays, ..
  52. Transforming Growth Factor-Beta (TGF-b) Signaling in Aged Skin
    Taihao Quan; Fiscal Year: 2013
    ..All of these features are attributable, at least in part, to impairment of the structural integrity of skin connective tissue. The structural component of skin connective tissue is the dermal extracellular matrix (ECM), which is ..
  53. Transforming Growth Factor-Beta Signal Transduction
    Joan Massague; Fiscal Year: 2013
    ..pathway triggers induction of Angiopoietin-like 4 expression for lung Infiltration and of interleukin-11 and connective tissue growth factor (CTGF) for osteolytic bone metastasis...
  54. Mechanism of skin-specific targeting of adult stem cells
    Olga Igoucheva; Fiscal Year: 2013
    ..This proposal outlines a dedicated strategy of cell-based therapy aimed at the treatment of connective tissue disease in a clinically relevant model, epidermolysis bullosa, which provides an excellent genetic target ..
  55. New Strategies and Screening Methods for Metalloproteinase Inhibition
    Seth M Cohen; Fiscal Year: 2010
    ..All MMPs utilize a zinc(II) ion to perform the catalytic hydrolysis of connective tissue and other biological substrates...
  56. Role of Muscle Connective Tissue in Muscle and Tendon Development
    Gabrielle Kardon; Fiscal Year: 2013
    ..of the vertebrate musculoskeletal system requires the coordinated morphogenesis of muscle, muscle connective tissue, tendon, and skeleton...
  57. Selective MRTF/SRF-Transcription Inhibitors: Novel Anti-fibrotics for IPF
    Vijaykumar M Baragi; Fiscal Year: 2013
    ..Outcomes measures include [unreadable]-smooth muscle actin ([unreadable]-SMA), connective tissue growth factor (CTGF) and MRTF...
    HARRY ALAN QUIGLEY; Fiscal Year: 2013
    ..methods into cohesive glaucoma studies in normal mice and mice with targeted alterations in specific connective tissue molecules is the unified theme of the present application...
  59. Urinary Biomarkers of Chronic Kidney Disease Pathology and Progression
    Sushrut S Waikar; Fiscal Year: 2013
    ..1L-18);urinary cystatin C;albumin;hepatocyte growth facmr (HGF);interferon-inducible protein (IP-10);and connective tissue growth factor (CTGF)...
  60. Immune Response to Small Nuclear Ribonucleoprotein Autoantigens
    Eric L Greidinger; Fiscal Year: 2011
    ..snRNP) self-antigens contributes to disease pathogenesis in Systemic Lupus Erythematosus (SLE) and Mixed Connective Tissue Disease (MCTD)...
  61. Role of the Leprecan Genes in Skeletal Formation
    Roy Morello; Fiscal Year: 2013
    ..3) enhance understanding of the Leprecan genes in skeletal development and other tissues, and 4) provide further insight into the role of these non-collagenous proteins in the etiology of human connective tissue disease, including OI.
  62. Matrix Metalloproteinase Regulation of Leukocyte Infiltration during Wound Repair
    LISA JOY MCCAWLEY; Fiscal Year: 2013
    ..including arrest on endothelium, migration through the endothelial barrier and directed migration through connective tissue towards the site of inflammation...
  63. The Role of Perineurial Glia in PNS Regeneration
    GWENDOLYN LEWIS; Fiscal Year: 2013
    ..The complete nerve is formed of axons surrounded by several layers of ensheathing glia and connective tissue. Regeneration requires all the cells in these layers to precisely coordinate their behaviors to ensure ..
  64. Cellular Physiology of the Aqueous Outflow Pathway
    Haiyan Gong; Fiscal Year: 2013 localized near the inner wall endothelium of Schlemm's canal (SC) and the juxtacanalicular connective tissue (JCT)...
  65. FASEB SRC on Matricellular Proteins in Development, Health, and Disease
    Joanne E Murphy-Ullrich; Fiscal Year: 2013
    ..extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix)...
  66. Peptide therapeutics for inhibiting abdominal adhesions
    CYNTHIA ELLEN LANDER; Fiscal Year: 2012
    ..MK2 is implicated in the connective tissue growth factor (CTGF) and collagen type I up regulation that promotes adhesions...
  67. Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular Diseases
    Dianna M Milewicz; Fiscal Year: 2013
    ..layers, either embedded between layers of elastin lamellae in large elastic arteries or in a matrix of connective tissue in smaller muscular arteries...
  68. Targeted Delivery of iPS-Endothelial Cells for the Repair of Cardiovascular Injur
    Yiu Fai Chen; Fiscal Year: 2013
    ..In addition, it is expected that the results wll fundamentally advance the field of cell-based therapy by providing a noninvasive and cost effective treatment modality. ..
  69. Phase II Study of Inhales Carbon Monoxide for the Treatment of Idiopathic Pulmona
    Ivan O Rosas; Fiscal Year: 2013
    ..Successful completion of this study will provide the basis for the design of a more definitive phase III clinical trial of low dose inhaled CO in IPF. (End of Abstract) ..
  70. 2013 LAM Symposium
    ..lungs and the cystic remodeling of pulmonary parenchyma, including the elaboration of metalloproteinases and connective tissue matrix by LAM cells...
  71. The Role of Basement Membrane Biomechanics in Cancer Cell Invasion
    Aron Parekh; Fiscal Year: 2013
    ..adjacent stromal tissue occurs independent of proteolytic degradation and/or mechanosensing by utilizing the connective tissue component of UBM-BM as a model for the stroma. Dr...
  72. Age related muscle fibrosis via PDGFRa signaling in fibroadipogenic progenitors
    ALISA ANNE MUELLER; Fiscal Year: 2013 regenerative capabilities, which is associated with fatty infiltration and the deposition of fibrou connective tissue. This fibrotic deposition is particularly harmful because it interferes with propr muscle contraction and ..
  73. Mechanism of Impaired Diabetic Oral Wound Healing
    Dana T Graves; Fiscal Year: 2013
    ..important health issue there have been surprisingly few studies that have examined mechanisms by which oral connective tissue healing is impaired by diabetes...
  74. Mechanobiology of Matrix Production by Corneal Fibroblasts
    Jeffrey W Ruberti; Fiscal Year: 2013
    ..Controlled fibroblast directional motility, self-organization and synthetic capacity are fundamental to connective tissue development, growth, remodeling and repair...
  75. Age-related shifts in epithelial lineages and tissue homeostasis in mammary gland
    Mark A Labarge; Fiscal Year: 2013
    ..Some age-associated changes in breast includes increased fat and estrogen receptor expression;decreased connective tissue, numbers of alveoli and overall breast density;changes in collagen-type expression, and discontinuities in ..
  76. Consortium for Translational Research in Marfan Syndrome
    FRANCESCO B RAMIREZ; Fiscal Year: 2013
    Marfan syndrome (MPS) is a common connective tissue disorder caused by mutations In flbrillln-1, the major Structural component of extracellular microfibrils...
  77. Targeting accessory proteins of alpha2C adrenergic receptor in Raynaud Phenomenon
    CATALIN FILIPEANU; Fiscal Year: 2013
    ..Raynaud's Disease (primary or idiopathic) and Raynaud's Syndrome when is associated with another connective tissue disorder like Lupus erythematosus or scleroderma...
  78. Dynamic limits on contraction of gastrointestinal smooth muscle
    MARION JOYCE SIEGMAN; Fiscal Year: 2013
    ..shortening depends on (a) external applied loads and (b) internal resistances provided by the extracellular connective tissue matrix which links smooth muscle cells together and to neighboring cells that are exerting force...
  79. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    Scleroderma is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, ..
    Anthony Visco; Fiscal Year: 2002
    ..have been reported between prolapse, joint hypermobility and abdominal striac suggesting a generalized connective tissue defect affecting pelvic organ support, joints and skin. One explanation is a defect in collagen biosynthesis...
  81. Metagenomic Study of the Periodontal Microbiome in Healthy and Diabetic Subjects
    Huiying Li; Fiscal Year: 2013
    ..The host immune response in T2Ds is known to be altered and evidence suggests a dysregulation in connective tissue metabolism...
  82. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..This project will provide an approach that is both compatible with minimally invasive techniques as well as provide a means to reduce post-operative complications while delivering therapeutic agents directly into the aneurysmal tissue. ..
  83. Influence of Innate Immunity on Xenobiotic-Induced Systemic Autoimmunity
    KENNETH MICHAEL POLLARD; Fiscal Year: 2013
    ..mechanisms in silica-induced autoimmunity, the linkage between silicosis and the risk of developing clinical connective tissue diseases such as SLE, suggest that immunological checkpoints in silicosis may contribute to silica-induced ..
  84. Promoting regeneration in muscular dystrophy with adipose derived stem cells.
    Gretchen A Meyer; Fiscal Year: 2013
    ..cells capable of regenerating damaged areas cause extensive replacement of contractile material with connective tissue and fat, decreasing contractile function (1, 2)...
    GORDON SHARP; Fiscal Year: 1990
    ..mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE), and undifferentiated connective tissue disease (UCTD), ..
  86. Abdominal Massage for Postoperative Adhesions and Ileus
    Geoffrey M Bove; Fiscal Year: 2013
    ..Intra-abdominal adhesions (pathological bands of fibrous connective tissue that develop after peritoneal injury) are a leading cause of bowel obstruction, infertility, chronic pain, ..
  87. The Epidemiology of Human Chondrogenic Progenitor Cells
    George F Muschler; Fiscal Year: 2013 defining strategies and principles for selecting and optimizing available sources of chondrogenic connective tissue progenitors (CTP- Cs)...
  88. Micro-Mechanical Role of Hypertension in Intimal Hyperplasia
    Ghassan S Kassab; Fiscal Year: 2013
  89. Nelfinavir in SLE: A Pilot Phase IIa Clinical Trial
    Betty Diamond; Fiscal Year: 2013
    ..Although considered a connective tissue disease, SLE harms a variety of organ systems, including the skin, joints, kidney and brain...
  90. Novel Anti-fibrotic Therapy for Diabetic Nephropathy
    Susan C Wright; Fiscal Year: 2013
    ..Two of the most important growth factors driving fibrosis in DN are transforming growth factor-b (TGFb) and connective tissue growth factor (CTGF), which is induced by TGFb...
  91. Development of a Mammalian Model for Rib Repair
    Francesca V Mariani; Fiscal Year: 2013 the middle of the resection site as well as from the ends, and 3), that the presence of the surrounding connective tissue sheath, or periosteum, is required for complete healing to occur...
  92. Regulated Assembly of the Tendon Extracellular Matrix
    David E Birk; Fiscal Year: 2013
    ..Finally, the underlying molecular pathophysiology of connective tissue disorders, e.g., classic Ehlers Danlos Syndrome, a newly defined collagen XII related myopathy, is addressed...
    Eric Kmiec; Fiscal Year: 1999
    Many inherited connective tissue diseases result from a point mutation or frame-shift mutation...
  94. Elastic mechanisms in locomotion
    THOMAS JAY ROBERTS; Fiscal Year: 2013
    ..Changes in the elastic properties of connective tissue elements within muscle are associated with several neuromuscular disorders, aging, and secondary to stroke ..
    Marie Francoise Doursout; Fiscal Year: 2004
    ..According to this hypothesis, the amount of connective tissue in the lung is increased when Pc is elevated for several days...
  96. Improved Adventitial Rapamycin Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2013
    ..If these Phase 2 studies are successful, we intend to move into pivotal clinical trials and ultimately seek FDA approval for a novel combination product. ..
  97. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010 largely caused by irreversible destruction of fibrillar collagen, the major structural protein in skin connective tissue (dermis)...
    ALADIN BORIEK; Fiscal Year: 1999
    ..Therefore, the mechanism of force transmissions between the fibers and connective tissue is more complex...
  99. Biophysics of Acupuncture: Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2009
    ..Now, robust evidence linking connective tissue to acupuncture structures has changed the research landscape and offers a new testable hypothesis: ..
  100. Automated Connective Tissue Torque Sensor
    Robert Davis; Fiscal Year: 2007
    ..project is to establish the usefulness of needle torque measurements for the diagnosis and monitoring of connective tissue pathology associated with chronic musculoskeletal conditions treated by manual therapies...
  101. Identification of Enhancers of Therapeutic Exon Skipping for DMD
    MELISSA JAN SPENCER; Fiscal Year: 2010
    ..topic: 04-AR-106 Cellular, Molecular and Genetic Therapies for Rare Inherited Diseases of Muscle, Skin and Connective Tissue and Bone...