tongue

Summary

Top Publications

  1. ncbi Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
  2. pmc N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:3472-83. 2012
  3. pmc Dual-task motor performance with a tongue-operated assistive technology compared with hand operations
    Ashley N Johnson
    School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA, USA
    J Neuroeng Rehabil 9:1. 2012
  4. ncbi Differences in tongue strength across age and gender: is there a diminished strength reserve?
    Scott R Youmans
    Department of Communication Sciences and Disorders, Long Island University, Brooklyn Campus, Brooklyn, NY 11201 5372, USA
    Dysphagia 24:57-65. 2009
  5. ncbi A novel approach based on computerized image analysis for traditional Chinese medical diagnosis of the tongue
    C C Chiu
    Institute of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ROC
    Comput Methods Programs Biomed 61:77-89. 2000
  6. ncbi Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue
    C F Huang
    School of Stomatology, Wuhan University, Wuhan, China
    Oral Dis 17:328-34. 2011
  7. ncbi Cross-modal plasticity revealed by electrotactile stimulation of the tongue in the congenitally blind
    Maurice Ptito
    PET Centre and CFIN, Aarhus University Hospitals, Aarhus, Denmark
    Brain 128:606-14. 2005
  8. pmc Integrating next-generation sequencing and traditional tongue diagnosis to determine tongue coating microbiome
    Bai Jiang
    Bioinformatics Division, TNLIST and Department of Automation, Tsinghua University, Beijing 100084, China
    Sci Rep 2:936. 2012
  9. pmc Long chain N-acyl homoserine lactone production by Enterobacter sp. isolated from human tongue surfaces
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:14307-14. 2012
  10. ncbi Measures of tongue function related to normal swallowing
    Scott R Youmans
    Department of Communication Sciences and Disorders, Long Island University, Brooklyn, New York, USA
    Dysphagia 21:102-11. 2006

Detail Information

Publications385 found, 100 shown here

  1. ncbi Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
    The aim of this study was to evaluate the microRNA expression patterns in squamous cell carcinoma (SCC) of the tongue.
  2. pmc N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:3472-83. 2012
    ..report the isolation of two AHL-producing Klebsiella pneumoniae strains from the posterior dorsal surface of the tongue of a healthy individual. Spent culture supernatant extracts from K...
  3. pmc Dual-task motor performance with a tongue-operated assistive technology compared with hand operations
    Ashley N Johnson
    School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA, USA
    J Neuroeng Rehabil 9:1. 2012
    ..control, navigation, and communication in individuals suffering from impairment or disability in hand functions, a Tongue Drive System (TDS) has been developed that allows for real time tracking of tongue motion in an unobtrusive, ..
  4. ncbi Differences in tongue strength across age and gender: is there a diminished strength reserve?
    Scott R Youmans
    Department of Communication Sciences and Disorders, Long Island University, Brooklyn Campus, Brooklyn, NY 11201 5372, USA
    Dysphagia 24:57-65. 2009
    Maximum tongue strength was investigated and compared to mean swallowing pressure elicited by the anterior tongue to calculate the percentage of maximum tongue strength used during swallowing in 96 participants with normal swallowing, ..
  5. ncbi A novel approach based on computerized image analysis for traditional Chinese medical diagnosis of the tongue
    C C Chiu
    Institute of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ROC
    Comput Methods Programs Biomed 61:77-89. 2000
    This research is aimed at building a computerized tongue examination system (CTES) based on computerized image analysis for the purpose of quantizing the tongue properties in traditional Chinese medical diagnosis...
  6. ncbi Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue
    C F Huang
    School of Stomatology, Wuhan University, Wuhan, China
    Oral Dis 17:328-34. 2011
    The aim of this study was to assess the expression levels of two proteins, such as PRDX6 and cyclophilin A (CypA), and to evaluate their relationship with clinicopathologic features and survival in tongue squamous cell carcinomas (TSCCs).
  7. ncbi Cross-modal plasticity revealed by electrotactile stimulation of the tongue in the congenitally blind
    Maurice Ptito
    PET Centre and CFIN, Aarhus University Hospitals, Aarhus, Denmark
    Brain 128:606-14. 2005
    ..We used PET to study cross-modal plasticity in the congenitally blind, using electrotactile stimulation of the tongue. Blind (n = 6) and sighted blindfolded controls (n = 5) were scanned before and after they were trained to use ..
  8. pmc Integrating next-generation sequencing and traditional tongue diagnosis to determine tongue coating microbiome
    Bai Jiang
    Bioinformatics Division, TNLIST and Department of Automation, Tsinghua University, Beijing 100084, China
    Sci Rep 2:936. 2012
    b>Tongue diagnosis is a unique method in traditional Chinese medicine (TCM). This is the first investigation on the association between traditional tongue diagnosis and the tongue coating microbiome using next-generation sequencing...
  9. pmc Long chain N-acyl homoserine lactone production by Enterobacter sp. isolated from human tongue surfaces
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:14307-14. 2012
    ..isolate T1-1 from the posterior dorsal surfaces of the tongue of a healthy individual. Spent supernatants extract from Enterobacter sp...
  10. ncbi Measures of tongue function related to normal swallowing
    Scott R Youmans
    Department of Communication Sciences and Disorders, Long Island University, Brooklyn, New York, USA
    Dysphagia 21:102-11. 2006
    The availability of objective measures of tongue function presents a possible supplement to the clinical dysphagia evaluation...
  11. ncbi Speech listening specifically modulates the excitability of tongue muscles: a TMS study
    Luciano Fadiga
    Dipartimento di Scienze Biomediche e Terapie Avanzate, Sezione di Fisiologia Umana, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Eur J Neurosci 15:399-402. 2002
    ..that, during speech listening, there is an increase of motor-evoked potentials recorded from the listeners' tongue muscles when the presented words strongly involve, when pronounced, tongue movements...
  12. ncbi Tongue pressure modulation during swallowing: water versus nectar-thick liquids
    Catriona M Steele
    Toronto Rehabilitation Institute, Toronto, ON M5G 2A2, Canada
    J Speech Lang Hear Res 53:273-83. 2010
    Evidence of tongue-palate pressure modulation during swallowing between thin and nectar-thick liquids stimuli has been equivocal...
  13. ncbi The effects of lingual exercise on swallowing in older adults
    Joanne Robbins
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Am Geriatr Soc 53:1483-9. 2005
    ..To determine the effects of an 8-week progressive lingual resistance exercise program on swallowing in older individuals, the most "at risk" group for dysphagia...
  14. pmc Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste
    Yijen A Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    J Physiol 586:2903-12. 2008
    ..These findings may also have implications for other sensory receptors that respond to acids, such as nociceptors...
  15. ncbi Functional MRI assessment of orofacial articulators: neural correlates of lip, jaw, larynx, and tongue movements
    Krystyna Grabski
    GIPSA lab, Département Parole and Cognition, UMR CNRS 5216, Grenoble Universités, France
    Hum Brain Mapp 33:2306-21. 2012
    ..cortical and subcortical regions associated with supralaryngeal motor control, participants produced lip, tongue and jaw movements while undergoing functional magnetic resonance imaging (fMRI)...
  16. ncbi Development of vocal tract length during early childhood: a magnetic resonance imaging study
    Houri K Vorperian
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Acoust Soc Am 117:338-50. 2005
    ..Measurements on lip thickness, hard- and soft-palate length, tongue length, naso-oro-pharyngeal length, mandibular length and depth, and distance of the hyoid bone and larynx from ..
  17. ncbi Reduced tongue pressure against the hard palate on the paralyzed side during swallowing predicts Dysphagia in patients with acute stroke
    Nobuko Hirota
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
    Stroke 41:2982-4. 2010
    ..The present study investigated the relationship between tongue motor deficits and dysphagia in patients with acute stroke.
  18. ncbi The mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruction
    Benedetto Longo
    Plastic Surgery Unit, Sant Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Plast Reconstr Surg 132:656-65. 2013
    Reconstruction of a functional tongue with proper motility and sensation after subtotal resection is a demanding procedure...
  19. ncbi Epithelial overexpression of BDNF or NT4 disrupts targeting of taste neurons that innervate the anterior tongue
    R F Krimm
    Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    Dev Biol 232:508-21. 2001
    ..the survival of geniculate ganglion neurons, which provide the sensory afferents for taste buds of the anterior tongue and palate...
  20. ncbi The effects of lingual exercise in stroke patients with dysphagia
    Joanne Robbins
    William S Middleton Memorial Veterans Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA
    Arch Phys Med Rehabil 88:150-8. 2007
    ..To examine the effects of lingual exercise on swallowing recovery poststroke...
  21. ncbi Age-related changes in tongue pressure during swallowing
    K Tamine
    Division of Oromaxillofacial Regeneration, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita City, Osaka 565 0871, Japan
    J Dent Res 89:1097-101. 2010
    Although swallowing movement is known to change with aging, age-related differences in the tongue pressure for propelling a bolus from the oral cavity into the pharynx have yet to be investigated in a physiological condition...
  22. ncbi EMMPRIN expression in tongue squamous cell carcinoma
    Zhiquan Huang
    Department of Oral and Maxillfacial Surgery, The Second Affiliated Hospital, Sun Yat Sen University, Guangdong, China
    J Oral Pathol Med 38:518-23. 2009
    ..The aim of this study was to investigate the relationship between clinico-pathologic characteristics and EMMPRIN, and prognostic significance of EMMPRIN expression in human tongue squamous cell carcinoma.
  23. ncbi Analysis of the relations between the shape of the reconstructed tongue and postoperative functions after subtotal or total glossectomy
    Yoshihiro Kimata
    Division of Plastic and Reconstructive Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Laryngoscope 113:905-9. 2003
    ..The objective was to investigate the relations of the shape of the reconstructed tongue to postoperative swallowing and speech functions.
  24. ncbi Closing an open-loop control system: vestibular substitution through the tongue
    Mitchell Tyler
    Wicab, Inc, 3510 W Beltline Hwy, Middleton, WI 53562, USA
    J Integr Neurosci 2:159-64. 2003
    ..accelerometer and a brain-machine interface that employs a unique pattern of electrotactile stimulation on the tongue. Moreover, postural stability persists for a period of time after removing the vestibular substitution, after ..
  25. ncbi A comparison of tongue and soft palate squamous cell carcinoma treated by primary surgery in terms of survival and quality of life outcomes
    J S Brown
    Regional Maxillofacial Unit, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Int J Oral Maxillofac Surg 35:208-14. 2006
    In the surgical management of oral cancer the resection and reconstruction of the mobile tongue and soft palate are most important if function is to be maintained...
  26. pmc Classifying EEG signals preceding right hand, left hand, tongue, and right foot movements and motor imageries
    Valerie Morash
    Human Motor Control Section, Medical Neurological Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Clin Neurophysiol 119:2570-8. 2008
    ..To use the neural signals preceding movement and motor imagery to predict which of the four movements/motor imageries is about to occur, and to access this utility for brain-computer interface (BCI) applications...
  27. ncbi On the origin of internal structure of word forms
    P F MacNeilage
    Department of Psychology, Department of Communication Sciences and Disorders, University of Texas, Austin, TX 78712, USA
    Science 288:527-31. 2000
    ..involve intrasyllabic consonant-vowel (CV) co-occurrence: labial (lip) consonants with central vowels, coronal (tongue front) consonants with front vowels, and dorsal (tongue back) consonants with back vowels...
  28. ncbi The bi-elliptical deformable contour and its application to automated tongue segmentation in Chinese medicine
    Bo Pang
    Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
    IEEE Trans Med Imaging 24:946-56. 2005
    Automated tongue image segmentation, in Chinese medicine, is difficult due to two special factors: 1) there are many pathological details on the surface of the tongue, which have a large influence on edge extraction; 2) the shapes of the ..
  29. ncbi UPPP combined with radiofrequency thermotherapy of the tongue base for the treatment of obstructive sleep apnea syndrome
    Emke van den Broek
    Department of Otorhinolaryngology, Head and Neck Surgery, St Lucas Andreas Hospital, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands
    Eur Arch Otorhinolaryngol 265:1361-5. 2008
    We investigated the outcome of uvulopalatopharyngoplasty (UPPP) combined with radiofrequency thermotherapy of the tongue base (RFTB) in patients with obstructive sleep apnea syndrome (OSAS) with both palatal and retroglossal obstruction, ..
  30. pmc Improved classification of Orthosiphon stamineus by data fusion of electronic nose and tongue sensors
    Ammar Zakaria
    Sensor Technology and Applications Group STAG, Universiti Malaysia Perlis UniMAP, 01000, Kangar, Perlis, Malaysia
    Sensors (Basel) 10:8782-96. 2010
    ..sources along with freshly prepared samples were discriminated using an electronic nose (e-nose) and an electronic tongue (e-tongue)...
  31. ncbi Cell types and lineages in taste buds
    Thomas E Finger
    Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Health Sciences Center, Denver, CO 80262 USA
    Chem Senses 30:i54-5. 2005
  32. ncbi Study on the tongue manifestations for the blood-stasis and toxin syndrome in the stable patients of coronary heart disease
    Yan Feng
    Graduate School of China Academy of Chinese Medical Sciences, Beijing, China
    Chin J Integr Med 17:333-8. 2011
    To explore the tongue manifestations for the blood-stasis and toxin syndrome in the stable patients of coronary heart disease (CHD) according to the acute cardiovascular events (ACEs) in one-year follow-up which based on the pathogenesis ..
  33. pmc Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis
    Francie Barron
    Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Development 138:2249-59. 2011
    ..The connective tissue of the tongue arises from cranial neural crest cell-derived ectomesenchyme within the mandibular portion of the first pharyngeal ..
  34. ncbi [Analysis of studies on pattern recognition of tongue image in traditional Chinese medicine by computer technology]
    Xiao qiang Yue
    Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhong Xi Yi Jie He Xue Bao 2:326-9. 2004
    The article analyzed the contemporary study of pattern recognition of tongue images in traditional Chinese medicine by computer technology from its key sectors...
  35. ncbi Visualization of phosphatidylcholine, lysophosphatidylcholine and sphingomyelin in mouse tongue body by matrix-assisted laser desorption/ionization imaging mass spectrometry
    Hirofumi Enomoto
    Department of Molecular Anatomy, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka, 431 3192, Japan
    Anal Bioanal Chem 400:1913-21. 2011
    The mammalian tongue is one of the most important organs during food uptake because it is helpful for mastication and swallowing. In addition, taste receptors are present on the surface of the tongue...
  36. ncbi Transoral robotic surgery of the tongue base in obstructive sleep Apnea-Hypopnea syndrome: anatomic considerations and clinical experience
    Claudio Vicini
    Department of Special Surgery, Ear, Nose, and Throat, and Oral Surgery Unit, Ospedale Morgagni Pierantoni, University of Pavia in Forlì, Italy
    Head Neck 34:15-22. 2012
    The purpose of our work was to describe, through cadaveric dissection, the anatomy of the tongue base with a robotic perspective and to demonstrate the feasibility of this approach in case of tongue base hypertrophy in Obstructive Sleep ..
  37. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer
    Yoshinori Shimizu
    Department of Otolaryngology, School of Medicine, Kanazawa University, Takaramachi 13 1, Ishikawa, Japan
    Auris Nasus Larynx 35:381-9. 2008
    ..MMP-1 -1607 2G/2G and IL-8 -251 A/A genotypes enhance transcriptional activity and may be associated with increased risk in malignant tumors. We therefore evaluated the impact of these SNPs in tongue squamous cell carcinoma (SCC).
  38. ncbi Molecular identification of bacteria on the tongue dorsum of subjects with and without halitosis
    M P Riggio
    Infection and Immunity Research Group, University of Glasgow Dental School, Glasgow, UK
    Oral Dis 14:251-8. 2008
    Compare the microbial profiles on the tongue dorsum in patients with halitosis and control subjects in a UK population using culture-independent techniques.
  39. ncbi Brain plasticity: 'visual' acuity of blind persons via the tongue
    E Sampaio
    Laboratoire d Etudes des Systèmes Perceptifs et Emotionnels, University Louis Pasteur, 12 rue Goethe, 67000 Strasbourg, France
    Brain Res 908:204-7. 2001
    ..information through a newly developed human-machine interface, with an array of electrical stimulators on the tongue, has been quantified using a standard Ophthalmological test (Snellen Tumbling E)...
  40. ncbi Tongue-jaw linkages in human feeding: a preliminary videofluorographic study
    J B Palmer
    Department of Physical Medicine and Rehabilitation, Good Samaritan Hospital, Baltimore, MD 21239, U S A
    Arch Oral Biol 42:429-41. 1997
    Motions of the tongue and jaw are closely coupled during feeding in mammals, but this relation has not been studied in humans...
  41. ncbi Pattern of tongue pressure on hard palate during swallowing
    Takahiro Ono
    Osaka University Graduate School of Dentistry, Osaka, Japan
    Dysphagia 19:259-64. 2004
    Contact of the tongue against the hard palate plays an important role in swallowing...
  42. ncbi Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds
    B Fritzsch
    Creighton University, School of Medicine, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Neurosci 15:563-76. 1997
    ..These data strongly suggest that the initial-development of many fungiform papillae and taste buds is independent of the specific taste innervation. It remains to be shown why others appear to be more dependent on proper innervation...
  43. ncbi Tongue movements during water swallowing in healthy young and older adults
    Catriona M Steele
    Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    J Speech Lang Hear Res 52:1255-67. 2009
    The purpose of this study was to explore the nature and extent of variability in tongue movement during healthy swallowing as a function of aging and gender...
  44. ncbi Risk factors for the prevalence of porcine cysticercosis in Mbulu District, Tanzania
    H A Ngowi
    Department of Veterinary Microbiology and Parasitology, Sokoine University of Agriculture, Morogoro, Tanzania
    Vet Parasitol 120:275-83. 2004
    ..This study suggests the need for further studies in order to design and implement effective prevention and control measures for porcine cysticercosis in Mbulu District, Tanzania...
  45. pmc Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells
    Hitoshi Kawaguchi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:17277-81. 2010
    ..Thus, PKD2L1-PKD1L3-mediated acid-evoked off responses occurred both in HEK293 cells and in native taste cells, suggesting the involvement of the PKD2L1-PKD1L3 complex in acid sensing in vivo...
  46. ncbi Development of spontaneous mouth/tongue movement and related neural activity, and their repression in fetal mice lacking glutamate decarboxylase 67
    Naoko Tsunekawa
    Obata Research Unit, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Eur J Neurosci 21:173-8. 2005
    ..At E14, mouth opening and tongue withdrawal were observed independently at frequency of 14/h each...
  47. pmc Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development
    Liam M Casey
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1830-44. 2006
    ..shelves initially grow vertically from the medial sides of the paired maxillary processes flanking the developing tongue and subsequently elevate and fuse with each other above the tongue to form the intact secondary palate...
  48. pmc The cells and logic for mammalian sour taste detection
    Angela L Huang
    Howard Hughes Medical Institute and Departments of Neurobiology and Neurosciences, University of California at San Diego, La Jolla, California 92093 0649, USA
    Nature 442:934-8. 2006
    ..In the tongue, PKD2L1 is expressed in a subset of taste receptor cells distinct from those responsible for sweet, bitter and ..
  49. ncbi Identification of a phospholipase C beta subtype in rat taste cells
    P Rössler
    Institute of Physiology, University of Hohenheim, Stuttgart, Germany
    Eur J Cell Biol 77:253-61. 1998
    ..These data indicate that a phospholipase C beta2 isoform mediates a denatonium benzoate-induced second messenger response of taste sensory cells in the circumvallate papillae...
  50. pmc Sox2 is required for development of taste bud sensory cells
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 20:2654-9. 2006
    Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae...
  51. ncbi Rapid quantitative assessment of fungiform papillae density in the human tongue
    Maryam Shahbake
    Children s Food Research and Education Unit, Centre for Advanced Food Research, College of Science, Technology and Environment, University of Western Sydney, Australia
    Brain Res 1052:196-201. 2005
    ..Oral Maxillofac. Surg. 55 (1997) 2-13], was measured on the dorsal surface of the anterior tongue of living humans using a digital camera and a videomicroscope...
  52. ncbi Molecular mechanisms of fat preference and overeating
    Dany Gaillard
    Physiologie de la Nutrition, UMR INSERM U866, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation ENSBANA, Universite de Bourgogne, Dijon, France
    Ann N Y Acad Sci 1141:163-75. 2008
    ..This paper provides a brief overview of postoral regulation of food intake by lipids and then highlights recent data suggesting the existence of a "fatty taste" which might contribute to lipid overeating and hence to the risk of obesity...
  53. ncbi Negative BOLD during tongue movement: a functional magnetic resonance imaging study
    Kiwako Sakamoto
    ITAB Institute for Advanced Biomedical Technologies, University of Chieti, Chieti, Italy
    Neurosci Lett 466:120-3. 2009
    ..imaging (fMRI) study was to evaluate negative blood oxygen level-dependent (BOLD) signals during voluntary tongue movement...
  54. pmc Electromyographic activity at the base and tip of the tongue across sleep-wake states in rats
    Jackie W Lu
    Department of Animal Biology 209E VET, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    Respir Physiol Neurobiol 167:307-15. 2009
    ..sleep-wake patterns and respiratory modulation of lingual EMG depend on the site of EMG recording within the tongue. In nine chronically instrumented rats, we recorded from 17 sites within the tongue and from the diaphragm across ..
  55. ncbi Pleomorphic lipoma of the tongue
    Esin Atik
    Department of Pathology, Inonu University Medical School, Turkey
    Otolaryngol Head Neck Surg 126:430-1. 2002
  56. ncbi Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice
    Junko Okano
    Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Dev Dyn 237:3059-70. 2008
    ..We investigated the mechanisms underlying the aberrant differentiation of tongue muscles in fetal mice exposed to exogenous RA in utero...
  57. ncbi Morphological evidence of the importance of epithelial tissue during mouse tongue development
    Jae Young Kim
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Oral Science Research Center, College of Dentistry, BK 21 Project for Medical Sciences, Yonsei University, Seoul, Korea
    Exp Cell Res 290:217-26. 2003
    The morphogenesis of fungiform papillae occurs in a stereotyped pattern on the dorsal surface of the tongue in mice from embryonic day 12 (E12) to E17...
  58. ncbi Handy measurement for tongue motion and coordination with laryngeal elevation at swallowing
    K Tsuga
    Department of Removable Prosthodontics, Faculty of Dentistry, Hiroshima University, Hiroshima, Japan
    J Oral Rehabil 30:985-9. 2003
    At the oral stage of swallowing, the tongue plays a major role and proper tongue performance is necessary to form the bolus and transfer it to the pharynx...
  59. ncbi Taste receptors in the gastrointestinal tract III. Salty and sour taste: sensing of sodium and protons by the tongue
    John A DeSimone
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1005-10. 2006
    ..Adaptation to sour arises from the activation of the basolateral sodium-hydrogen exchanger isoform-1 by an increase in intracellular calcium that sustains the tonic phase of the sour taste response...
  60. ncbi Tongue coating and tongue brushing: a literature review
    M M Danser
    Department of Periodontology, Academic Centre for Dentistry, Amsterdam, The Netherlands
    Int J Dent Hyg 1:151-8. 2003
    The present paper reviews the role of the tongue as a habitat for oral microorganisms and the potential need for tongue cleaning as part of daily oral hygiene. In addition tongue coating is described...
  61. ncbi A review of the advantages of the anterolateral thigh flap in head and neck reconstruction
    Jagdeep S Chana
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 10591, Taiwan, ROC
    Br J Plast Surg 57:603-9. 2004
  62. pmc N-acyl homoserine lactone-producing Pseudomonas putida strain T2-2 from human tongue surface
    Jian Woon Chen
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:13192-203. 2013
    ..This is the first report of the finding of quorum sensing of P. putida strain T2-2 isolated from the human tongue surface and their quorum sensing molecules were identified.
  63. ncbi Computerized tongue diagnosis based on Bayesian networks
    Bo Pang
    Department of Computer Science and Engineering, Harbin Institute of Technology, Harbin 150001, PR China
    IEEE Trans Biomed Eng 51:1803-10. 2004
    b>Tongue diagnosis is an important diagnostic method in traditional Chinese medicine (TCM)...
  64. ncbi Tongue movements in feeding and speech
    Karen M Hiiemae
    Institute for Sensory Research, Department of Bioengineering and Neuroscience, Syracuse University, Syracuse, NY 15244 5290, USA
    Crit Rev Oral Biol Med 14:413-29. 2003
    The position of the tongue relative to the upper and lower jaws is regulated in part by the position of the hyoid bone, which, with the anterior and posterior suprahyoid muscles, controls the angulation and length of the floor of the ..
  65. ncbi Oral and pharyngeal reflexes in the mammalian nervous system: their diverse range in complexity and the pivotal role of the tongue
    A J Miller
    Department of Growth and Development, School of Dentistry, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0438, USA
    Crit Rev Oral Biol Med 13:409-25. 2002
    ..Most of the reflexes affect the diversity of muscles that compose the tongue, which is vital to all stages of feeding and which continually affects the patency of the airway...
  66. pmc Tongue Base Reduction with Thyro-Hyoido-Pexy (TBRTHP) vs. Tongue Base Reduction with Hyo-Epiglottoplasty (TBRHE) in mild-severe OSAHS adult treatment. Preliminary findings from a prospective randomised trial
    C Vicini
    ENT and Oral Surgery Unit, Department of Special Surgery, G B Morgagni L Pierantoni Hospital, University of Pavia in Forlì, Forli, Italy
    Acta Otorhinolaryngol Ital 30:144-8. 2010
    In a preliminary prospective randomised study, a series of 5 patients submitted to classic Tongue Base Reduction with Hyo-Epiglottoplasty (TBRHE according to Chabolle et al...
  67. ncbi An optimized tongue image color correction scheme
    Xingzheng Wang
    Biometrics Research Center, Department of Computing, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    IEEE Trans Inf Technol Biomed 14:1355-64. 2010
    ..This is a serious problem in computer-aided tongue image analysis because it relies on the accurate rendering of color information...
  68. ncbi The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis
    J A Rothnagel
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Differentiation 65:119-30. 1999
    ..of the K6a transgene paralleled that of the endogenous genes in all K6 expressing tissues, except in the tongue. The K6b transgene was also expressed in these tissues but, in contrast to K6a, was only expressed in suprabasal ..
  69. ncbi Objectified study on tongue images of patients with lung cancer of different syndromes
    Wan Su
    Department of Oncology, Longhua Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Chin J Integr Med 17:272-6. 2011
    To describe the characteristic of tongue images of patients with lung cancer of different Chinese medicine (CM) syndromes and to reveal the elemental rule on the changes of the tongue images.
  70. ncbi Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue
    Pollianna M Alves
    Dentistry Department, State s University of Paraíba, Campina Grande, PB, Brazil
    Pathol Res Pract 207:236-40. 2011
    ..the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological ..
  71. pmc Saliva and tongue coating pH before and after use of mouthwashes and relationship with parameters of halitosis
    Elen de Souza Tolentino
    Department of Stomatology, Bauru School of Dentistry, University of Sao Paulo, Bauru, SP, Brazil
    J Appl Oral Sci 19:90-4. 2011
    The aim of this work was to evaluate saliva and tongue coating pH in oral healthy patients with morning bad breath before and after use of different oral mouthrinses.
  72. ncbi Hyoid and tongue surface movements in speaking and eating
    Karen M Hiiemae
    Department of Bioengineering and Neuroscience, Institute for Sensory Research, Syracuse University, Syracuse, NY 13244 5290, USA
    Arch Oral Biol 47:11-27. 2002
    The human hyoid moves continuously in feeding, facilitating movements of the tongue surface and the processing and transport of food...
  73. ncbi Surgical aspects of a lower face, mandible, and tongue allotransplantation
    Pedro C Cavadas
    Department of Reconstructive Surgery, Clinica Cavadas, Valencia, Spain
    J Reconstr Microsurg 28:43-7. 2012
    ..The technical aspects of a composite lower face transplantation including the tongue, floor of the mouth, and most of the mandible are detailed...
  74. ncbi The importance of stromal inflammation in squamous cell carcinoma of the tongue
    Lotta Lundqvist
    Department of Medical Biosciences Pathology, Umea University, Umea, Sweden
    J Oral Pathol Med 41:379-83. 2012
    ..SCCHN is a heterogeneous group of tumours including tumours located in the oral cavity, of which the majority is located in the tongue.
  75. pmc TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis
    Ryoichi Hosokawa
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Dev Biol 341:186-95. 2010
    ..Our study shows that cranial neural crest (CNC) cells give rise to the fibroblastic cells of the tongue skeletal muscle in mice...
  76. ncbi Modeling tongue surface contours from Cine-MRI images
    M Stone
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    J Speech Lang Hear Res 44:1026-40. 2001
    This study demonstrated that a simple mechanical model of global tongue movement in parallel sagittal planes could be used to quantify tongue motion during speech...
  77. pmc Sustained cortical and subcortical neuromodulation induced by electrical tongue stimulation
    Joseph C Wildenberg
    Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53705, USA
    Brain Imaging Behav 4:199-211. 2010
    This pilot study aimed to show that information-free stimulation of the tongue can improve behavioral measures and induce sustained neuromodulation of the balance-processing network in individuals with balance dysfunction...
  78. ncbi A novel murine beta -defensin expressed in tongue, esophagus, and trachea
    H P Jia
    Departments of Pediatrics, Genetics Ph D Program, and Microbiology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 275:33314-20. 2000
    ..The peptide shares approximately 40% identity with HBD-2. MBD-4 mRNA was expressed in the esophagus, tongue, and trachea but not in any of 20 other tissues surveyed...
  79. ncbi Effects of two types of tongue strengthening exercises in young normals
    Cathy Lazarus
    Voice, Speech and Language Service and Swallowing Center, Northwestern University Medical School, Chicago, Ill, USA
    Folia Phoniatr Logop 55:199-205. 2003
    This pilot study examines the effects of two types of tongue strengthening exercises on tongue function measures of strength and endurance in a group of 31 healthy young subjects...
  80. ncbi Arteriovenous malformations of the tongue: a spectrum of disease
    Gresham T Richter
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Arkansas Children s Hospital, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA
    Laryngoscope 117:328-35. 2007
    To examine our vascular anomalies team's experience with tongue arteriovenous malformations (AVM) with specific emphasis on the spectrum on disease and surgical management.
  81. ncbi Can a plantar pressure-based tongue-placed electrotactile biofeedback improve postural control under altered vestibular and neck proprioceptive conditions?
    N Vuillerme
    TIMC IMAG Laboratory, University of Grenoble, Faculty of Medicine, La Tronche Cedex, France
    Neuroscience 155:291-6. 2008
    We investigated the effects of a plantar pressure-based tongue-placed electrotactile biofeedback on postural control during quiet standing under normal and altered vestibular and neck proprioceptive conditions...
  82. ncbi Hemispheric dominance of tongue control depends on the chewing-side preference
    H Shinagawa
    Maxillofacial Orthognathics, Graduate School, Tokyo Medical and Dental University, Japan
    J Dent Res 82:278-83. 2003
    ..The purpose of this study was to apply BOLD-fMRI to identify brain areas responsible for producing tongue movements and their relation to chewing-side preference in 15 normal right-handed volunteers...
  83. ncbi Vanilloid receptor expression in the rat tongue and palate
    M A Kido
    Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    J Dent Res 82:393-7. 2003
    ..Immunohistochemistry revealed that the taste papillae in the tongue and palate are richly innervated by VR1-immunoreactive nerve fibers...
  84. ncbi Morphology and function of the feeding apparatus of Pelusios castaneus (Chelonia; Pleurodira)
    P Lemell
    Department of Comparative Anatomy and Morphology, Institute of Zoology, University of Vienna, Austria
    J Morphol 244:127-35. 2000
    ..Gross morphological investigations of skull, hyoid, tongue, and connected musculature, as well as scanning electron microscopy of the tongue surface, show typical features ..
  85. pmc Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture
    Wilfried Engelke
    Dentistry Centre, Department of Maxillofacial Surgery, University of Gottingen, Gottingen, Germany
    Clin Oral Investig 15:165-76. 2011
    ....
  86. ncbi Instrument measurement of lingual force variability reflects tardive tongue dyskinesia
    J P Koning
    Psychiatric Centre Symfora Group, Utrechtseweg 266, Amersfoort, 3800 DB, The Netherlands
    J Med Eng Technol 34:71-7. 2010
    Tardive tongue dyskinesia is often under-diagnosed or misdiagnosed. Instrument measurement of lingual force variability may be a valid and reliable method for assessing tardive tongue dyskinesia...
  87. ncbi Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score
    Z Yilmaz
    Clinical and Diagnostic Oral Sciences, St Bartholomew s and Royal London School of Medicine and Dentistry, Queen Mary College, University of London, and Peripheral Neuropathy Unit, Hammersmith Hospital, London, UK
    J Clin Neurosci 14:864-71. 2007
    ..with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin...
  88. ncbi Tongue pressure patterns during water swallowing
    Daniel Kennedy
    Department of Oral Sciences, University of Otago, Dunedin, New Zealand
    Dysphagia 25:11-9. 2010
    ..to be characterised by the sequential elevation of the front, middle, and posterior regions of the dorsum of the tongue. However, the coordinated orchestration of lingual movement is still poorly understood...
  89. ncbi The effects of a chlorhexidine mouthrinse on culturable microorganisms of the tongue and saliva
    P K Sreenivasan
    Colgate Palmolive Company, Piscataway, NJ 08855, USA
    Microbiol Res 159:365-70. 2004
    ..CHX) mouthrinse and a control rinse on a range of microflora including those implicated in halitosis on the tongue and saliva...
  90. pmc Evolution of the structure and function of the vertebrate tongue
    Shin Ichi Iwasaki
    Advanced Research Center, The Nippon Dental University School of Dentistry at Niigata, Japan
    J Anat 201:1-13. 2002
    ..The tongue, which plays a very important role in food intake by vertebrates, exhibits significant morphological variations ..
  91. pmc Immune cells of the human peripheral taste system: dominant dendritic cells and CD4 T cells
    Pu Feng
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Brain Behav Immun 23:760-6. 2009
    ..These observations provide a basic anatomical foundation for the immune response in the healthy human tongue as a basis for subsequent disease-related studies, but none of the present data indicate that the immune cell ..
  92. pmc The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells
    Pu Feng
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 35:501-9. 2010
    ..The T cells stand ready to respond to inflammatory and infectious insults and may play a role in the taste alterations observed during acute and chronic inflammatory states...
  93. ncbi Isolated lingual leishmaniasis
    F Habibzadeh
    NIOC Medical Education and Research Center, Shiraz University, Iran
    J Postgrad Med 51:218-9. 2005
    ..The lesion was totally excised. The patient was cured completely and is doing well after four years of follow-up, with no medical treatment...
  94. ncbi Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch
    J R Chin
    Department of Anatomy, University of California, San Francisco 94143 0750, USA
    Development 124:1519-30. 1997
    We have investigated the role of proteinases in the developmental program of bone, cartilage, tongue muscle and epithelial differentiation and remodeling in the mandibular arch during murine embryogenesis...
  95. ncbi Changes in the lingual muscles of obese rats induced by high-fat diet feeding
    Takashi Saito
    Department of Dentistry, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Arch Oral Biol 55:803-8. 2010
    ..To elucidate the influences of obesity on the properties and volume of lingual (genioglossus and geniohyoid) muscles in obese rats...
  96. ncbi [Cysticercosis as a rare cause of a tumor of the tongue]
    B Roth
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankheiten des Universitätsklinikums Hamburg Eppendorf
    Laryngorhinootologie 82:564-7. 2003
    This article presents the case of a 19-year-old male patient with cysticercosis in the tongue and the CNS...
  97. ncbi Tactile-'visual' acuity of the tongue in early blind individuals
    Daniel Robert Chebat
    Chaire de Recherche Harland Sanders, Ecole d Optometrie, Universite de Montreal, Quebec, Canada
    Neuroreport 18:1901-4. 2007
    This study compares the 'tactile-visual' acuity of the tongue for 15 early blind participants with that of 24 age-matched and sex-matched sighted controls...
  98. ncbi Relationship between maxillofacial morphology and deglutitive tongue movement in patients with anterior open bite
    Tatsuya Fujiki
    Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Am J Orthod Dentofacial Orthop 125:160-7. 2004
    We reported previously that patients with anterior open bite had tongue tip protrusion, slower movement of the rear part of the dorsal tongue, and earlier closure of the nasopharynx during deglutition...
  99. ncbi Impact of tongue cleansers on microbial load and taste
    M Quirynen
    Department of Periodontology, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium
    J Clin Periodontol 31:506-10. 2004
    b>Tongue cleaning has been advocated to improve oral malodor and to reduce reinfection of periodontal niches by eliminating tongue coating and/or reducing putrefaction by bacteria.
  100. pmc Oral thresholds and suprathreshold intensity ratings for free fatty acids on 3 tongue sites in humans: implications for transduction mechanisms
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907 2059, USA
    Chem Senses 34:415-23. 2009
    ..They reportedly differ in their distribution on the tongue and each has a unique range of ligand specificities...
  101. pmc The effects of aging on hypoglossal motoneurons in rats
    Emilie C Schwarz
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Dysphagia 24:40-8. 2009
    ..changes might help explain alterations at the neuromuscular junction and changes in the contractile properties of tongue muscle that have been reported in older rats...

Research Grants76

  1. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..It is widely accepted that obstructive apnea is caused largely by abnormal activation of tongue muscles, which are in turn controlled by hypoglossal motoneurons...
  2. Molecular Studies of Bone Marrow Failure
    Monica Bessler; Fiscal Year: 2013
    ..patients present with additional clinical manifestations, including alterations of the skin, white spots on the tongue and brittle fingernails, which led to the disease name, dyskeratosis congenita (DC)...
  3. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..To determine if AMP peptide could protect the oral mucosa in vivo, radiation- induced injuries of the mouse tongue and hamster buccal mucosa were studied in models of oral mucositis...
  4. Diet and Alcohol Induced Epigenetic Changes in Oral Cavity Carcinogenesis Model
    Lorraine J Gudas; Fiscal Year: 2013
    ..that alcohol may contribute to carcinogenesis in epithelial stem/progenitor cells of the basal layer of the tongue by promoting epigenetic changes, such as histone modifications or greater DNA methylation at CpG cytosines, which ..
  5. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..Aim 1 will test the hypotheses that injection of AAV9 vector encoding the GAA gene (AAV9-GAA) into the tongue of Pompe (Gaa-/-) mice will cause GAA expression in muscle and motoneurons, and will restore tongue motor function...
  6. Physiology and regulation of T2R bitter taste receptors in enteroendocrine cells
    Timothy F Osborne; Fiscal Year: 2013
    ..coupled receptor (GPCR) genes and are predominantly expressed in taste receptor cells (TRCs) on the surface of the tongue and surrounding oral tissue...
  7. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    ..Many command options, such as voice commands, tongue-touch keypads, or chin- operated joysticks, can be awkward and can interfere with talking, eating, and normal ..
  8. Small Interfering RNAs: Inhibition of Oral Carcinogenesis in a Mouse Model
    Lorraine J Gudas; Fiscal Year: 2010
    ..this proposed study are: 1) To design effective routes for siRNA delivery into the epithelial cells of the mouse tongue and to measure the gene silencing effects of applied siRNAs...
  9. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ..we will apply in vivo bioluminescence imaging and micro- computed tomography, followed by histology of tongue, floor of mouth, and mandible...
  10. Mechanisms of Adult Taste Bud Regeneration
    Linda A Barlow; Fiscal Year: 2013
    ..is mediated by taste buds comprising aggregates of heterogeneous receptor cells within specialized papillae on the tongue. In adult mammals, taste receptor cells, despite their functional similarities to neurons, are continually renewed ..
  11. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    ..for example, which tooth the plaque was taken from, or whether a sample was from the side or the top of the tongue), spatial information at the micron level--namely the level of microbial community organization--is lost...
  12. GE Healthcare Discovery MR750 3T MRI System
    FRANK KOROSEC; Fiscal Year: 2010
    ..of epilepsy in adults and children and its response to therapy, the impact of stroke on swallowing and response to tongue exercises, the effects of injury on muscle morphology and function, and many other medical issues...
  13. The Role of Ets1 in Melanocyte Development
    Lidia Kos; Fiscal Year: 2012
    ..including sensorineural deafness, cranio-facial abnormalities, cardiac malformations, impaired thyroid and tongue, and pigmentation disorders...
  14. Elucidating the role of TIN2L at the telomere and in dyskeratosis congenita
    Nya D Nelson; Fiscal Year: 2013
    ..Patients with DC have a particularly high risk of developing acute myeloid leukemia and tongue cancer in comparison to the general population, 200 and 1100 fold respectively...
  15. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..On the systemic level, cells that function as hydrogen ion sensors in the brain, the heart, the gut,and the tongue evoke reflexive responses that serve to mitigate and ultimately eliminate the acidic challenge...
  16. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..PRS occurs in about 1 in every 800 live births and is characterized by small lower jaw, improperly positioned tongue and posterior cleft of the palate, which can result in upper airway obstruction and feeding difficulties...
  17. Taste organs: formation and regulation
    Hongxiang Liu; Fiscal Year: 2013
    ..stimuli into neural signals conveyed to the central nervous system, reside in taste papillae in the mammalian tongue. Therefore, taste papillae host the epithelium that will differentiate to include taste bud cells...
  18. Neural Substrates of Oral Motor Dysfunction in Parkinson's Disease
    EMILY KATE PRINE; Fiscal Year: 2010
    ..Intracortical microstimulation will then be used to derive motor maps of forelimb, tongue and jaw movements and the level of striatal dopamine depletion will be determined using immunohistochemistry...
  19. Eph/Ephrin signaling in Taste Nerve Targeting
    MICHAEL WILLIAM ROCHLIN; Fiscal Year: 2010
    ..first aim of the proposed work is to determine which Ephs and ephrins are expressed in gustatory epithelia in the tongue and palate and the sensory nerves that innervate them during embryonic development...
  20. Chemoprevention of upper aerodigestive tract cancer by dietary zinc
    Louise Y Y Fong; Fiscal Year: 2013
    ..UADT) cancer, including esophageal squamous cell cancer (ESCC, predominant subtype of esophageal cancer) and tongue SCC (major site of oral cancer), remains deadly...
  21. Isolation and characterization of the normal and cancer stem cells of the tongue.
    Agnieszka Kobielak; Fiscal Year: 2012
    ..Furthermore, carcinoma of the tongue appears to account for the majority of this increase in incidence and has now become the second most common ..
  22. Head and Neck Cancer Risk Prediction Model
    Yuan Chin Amy Lee; Fiscal Year: 2013
    ..In recent years, tonsillar and tongue cancer incidence, and oral cavity and pharyngeal cancer incidence in young women have been increasing at alarming ..
  23. REGULATION OF EBV INFECTION IN EPITHELIAL CELLS
    SHANNON CELESTE KENNEY; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Epstein-Barr virus infection in AIDS patients causes both B cell lymphomas and a lesion on the tongue known as oral hairy leukoplakia...
  24. Modulation of miR-31 by dietary zinc deficiency in rat esophageal carcinogenesis
    Louise Y Y Fong; Fiscal Year: 2012
    ..In rodents Zn-deficiency induces a hyperplastic phenotype in tongue and esophagus by causing cell proliferation and changes in gene expression...
  25. Regulation of Oral Bacteria by Pattern Recognition Receptors
    Naohiro Inohara; Fiscal Year: 2012
    ..Oral bacteria colonize the surface of teeth, prostheses, gums and tongue by forming biofilm, an organized community of microbes in which microbial organisms highly interact with each ..
  26. Upper airway control during disrupted and misaligned sleep
    LESZEK K KUBIN; Fiscal Year: 2013
    ..effects on lingual EMG across sleep-wake states in chronically instrumented rats with stimulated use of the tongue and in anesthetized rats with direct activation of XII motoneurons with 5-HT...
  27. VERTEBRATE PRIMARY MOUTH FORMATION
    Hazel L Sive; Fiscal Year: 2013
    ..It is critical for food ingestion, and may contribute to the tongue and teeth...
  28. Epigenetic determinants of Epstein-Barr virus and cellular DNA in oral diseases
    SHANNON CELESTE KENNEY; Fiscal Year: 2013
    ..oropharyngeal epithelial cells is associated with at least two types of disease: oral hairy leukoplakia (OHL), a tongue lesion caused by lytic EBV infection of differentiated epithelial cells, and nasopharyngeal carcinoma (NPC), a ..
  29. Lingual and Laryngeal Muscle Plasticity
    NADINE PATTAKOS CONNOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skeletal muscles, including those of the tongue and larynx, are capable of considerable plasticity based on changing demands and levels of activity...
  30. The Use of Electropalatography in the Treatment of Apraxia of Speech
    Shannon C Mauszycki; Fiscal Year: 2012
    ..One method for examining the tongue's role in articulation is electropalatography (EPG)...
  31. Predictors of Speech Quality after Tongue Cancer Surgery
    Maureen Stone; Fiscal Year: 2013
    ..studies have shown a five-fold increase in the incidence of squamous cell carcinomas of the oral portion of the tongue among young men and a six-fold increase among young women...
  32. Modeling Adherence to Swallowing and Dental Regimens in Head and Neck Cancer
    Eileen H Shinn; Fiscal Year: 2010
    ..To prevent dysphagia, patients must perform motor exercises that strengthen the tongue and increase range of motion in oropharyngeal structures. However, adherence was low, just 9...
  33. MICROINVASIVE TREATMENT OF SLEEP APNEA WITH THE LINGUAFLEX TISSUE RETRACTOR II
    Ira Sanders; Fiscal Year: 2010
    ..A new technology, the LinguaFlex Tongue Retractor (LTR-I), was developed and recently tested in pre-clinical and clinical trial...
  34. Targeted Liposomal Delivery of CD147 siRNA to Murine Head and Neck Cancer Models
    Nadarajah Vigneswaran; Fiscal Year: 2010
    ..model;(2) the synergistic effect of CD147 siRNA to the chemopreventive potential of EGFR-TKI against 4-NQO-induced tongue cancer in CBA mice...
  35. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    Carole L Marcus; Fiscal Year: 2012
    ..weight loss will result primarily in a decrease in the size of the parapharyngeal fat pads, but may also affect tongue and soft palate size...
  36. Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer
    Eileen H Shinn; Fiscal Year: 2013
    ..To prevent this, patients can perform motor exercises that strengthen the tongue and increase range of motion in oropharyngeal structures...
  37. Small non-coding RNAs in Porphyromonas gingivalis
    JANINA P contact LEWIS; Fiscal Year: 2010
    ..pockets it also is present in other niches of the oral cavity enroute to the periodontal pockets such as tongue as well as it can access distant parts of body such as cardiovascular system and heart tissues...
  38. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2012
    ..Alterations in the motor nerves and endplates innervating the pharyngeal and tongue muscles will be also documented using quantitative techniques...
  39. Development and Translational Assesment of a Tongue-Based Assistive Neuro-Technol
    Maysam Ghovanloo; Fiscal Year: 2010
    ..validating assistive neuro-technologies: 06-NS-104 Abstract/summary: Development and Translational Assessment of a Tongue-Based Assistive Neuro-Technology (ANT) for Individuals with Severe Neurological Disorders More than two million ..
  40. Tongue-pressure timing for liquid flow detection and control in swallowing
    CATRIONA MARGARET STEELE; Fiscal Year: 2012
    ..The tongue plays a critical role in containing liquids in the mouth, and in directing and controlling flow through the ..
  41. International collaborative research to develop quantitive sensory testing guidel
    Mark Drangsholt; Fiscal Year: 2009
    ..internationally at three universities, on two visits, to measure reliability of the entire QST battery without tongue or taste assessments...
  42. Intestinal Microecology, Inflammatory Markers and Necrotizing Enterocolitis
    Josef Neu; Fiscal Year: 2013
    ..In addition, finding inflammation-related markers using a non-invasive technique such as fecal analysis or tongue scraping to determine individuals at highest risk for the development of NEC will improve our chances of only ..
  43. Neurotrophin Specificity and Function in the Taste System
    Christopher Nosrat; Fiscal Year: 2009
    ..neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) play important roles in the innervation of the developing tongue. BDNF null-mutated mice exhibit specific impairments related to innervation and development of the gustatory ..
  44. Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease
    Mihaela Teodorescu; Fiscal Year: 2013
    ..responsive patients with OLD and those with UAWs more susceptible to collapse at baseline, through alterations in tongue muscle function and fat accumulation in the UAW surrounding structures...
  45. Integrative epigenomic/genomic profiling and biomarker discovery in HPV+ and HPV-
    MAUREEN AGNES SARTOR; Fiscal Year: 2013
    ..Currently, treatment of head and neck SCC (HNSCC) is not based on HPV status. The incidence of tonsil and tongue cancers have been increasing annually and many contain high risk HPV...
  46. Inhibition of Rat Oral Carcinogenesis by Dietary Black Raspberries
    Christopher M Weghorst; Fiscal Year: 2013
    ..Therefore, another suitable animal model of oral cancer must be employed. The rat tongue/4NQO system of oral carcinogenesis represents such an established and well-studied model for the investigation of ..
  47. Endophenotypes of Sleep Apnea and Role of Obesity
    ALLAN IAN PACK; Fiscal Year: 2013
    ..It is proposed that the major pathogenetic mechanism is fat infiltration of tongue and other upper airway structures that increase their size, thereby reducing airway size and affecting the ..
  48. MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    Yang Chai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The tongue is an important muscular organ and carries out crucial physiological functions...
  49. 2011 Symposium on Flavors and Feeding
    Richard D Mattes; Fiscal Year: 2011
    ..Further, new effective stimuli (e.g., fatty acids, calcium);new locations for their receptors (tongue, intestine, lung, muscle) and new effects (e.g., release of gut peptides) have been proposed...
  50. Neural Mechansims of Oil Reward
    Ralph Norgren; Fiscal Year: 2010
    ..individual tactile, taste, and thermal fibers of the gustatory and somatosensory nerves that innervate the tongue. Specific Aims 2 and 3 will identify the forebrain structures that mediate the hedonic value of oil...
  51. Comprehensive Analysis of Genetic Alterations in Oral Cancer
    JEFFREY NICHOLAS contact MYERS; Fiscal Year: 2010
    ..and identify structural abnormalities over the whole genome for 100 cases of squamous cell carcinoma of the oral tongue (SCCOT)...
  52. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2012
    ..when TrkB and p75 are required for specific aspects of gustatory development, including axonal extension into the tongue, target selection, and geniculate neuron/taste bud survival...
  53. Cellulose-Based Strips for Human Taste Evaluation
    Lloyd Hastings; Fiscal Year: 2010
    ..They dissolve almost immediately when placed on the tongue, show minimal volatility of released taste stimuli, and provide the possibility of regional testing of the tongue...
  54. MicroRNA Profiling and Tumor Progression in HPV+ Oropharyngeal Cancer
    Daniel L Miller; Fiscal Year: 2013
    ..3% and 0.6% yearly between 1973 and 2004 for base of tongue and tonsillar carcinomas, respectively...
  55. SYNAPTIC MECHANISMS IN RETINA
    Malcolm M Slaughter; Fiscal Year: 2012
    ..We found two taste receptor proteins in rat retina that are identical to those in the tongue. Unlike the tongue, a key third protein subunit is missing in retina...
  56. Exercise as a Treatment for Tongue Weakness
    NADINE PATTAKOS CONNOR; Fiscal Year: 2013
    ..The tongue has a vital role in swallowing and poor lingual function is associated with swallowing impairment...
  57. Prevention of Depression in Patients Being Treated for Head and Neck Cancer
    William J Burke; Fiscal Year: 2010
    ..Depression can also lead to suicide;patients with cancers of the larynx and tongue account for 2 of the 3 highest suicide rates in cancer patients...
  58. Guiding the Treatment of Anterior Eye Disease with Optical Coherence Tomography
    David Huang; Fiscal Year: 2013
    ..and host corneas with a combination of excimer laser to create smooth interfaces and femtosecond laser to create tongue-in-groove edge fits. Pilot clinical trials of these techniques are proposed...
  59. Nonmuscle myosins in craniofacial morphogenesis and orofacial clefting
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..primordia called palatal shelves project vertically into the oral cavity, reorient to a position above the tongue, and then fuse at the midline...
  60. Oral Colonization of Aggregatibacter in Primates
    Daniel H Fine; Fiscal Year: 2012
    ..Aim 2 will assess the location, level and timing of Aa found on BECs, tongue and teeth comparing un-inoculated and wild type inoculated Aa to Aa with mutations in aae and apiA, a double ..
  61. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte M Mistretta; Fiscal Year: 2013
    ..that direct development of the fungiform papilla: the sense organ residence of taste buds on the anterior tongue. However, the complexity of the papilla taste organ, composed of specific signaling compartments and encompassing ..
  62. Strategies for the Treatment of Dysphagia in Patients with Alzheimer's Disease
    Jerilyn A Logemann; Fiscal Year: 2013
    ..or liquid in a cup, poor recognition of food in the mouth and apraxia of swallow, meaning they cannot coordinate tongue movements to initiate a swallow in the mouth or to propel the food back to the pharynx...
  63. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2001
    What is special about the human tongue that allows it to perform the movements that are unique to human speech and swallowing? The biomechanics of the tongue are dependent on its anatomy, and some of the most basic facts of human tongue ..
  64. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    What is special about the human tongue that allows it to perform the movements that are unique to human speech and swallowing? The biomechanics of the tongue are dependent on its anatomy, and some of the most basic facts of human tongue ..
  65. LINGUAL SEROUS GLANDS--REGULATION OF ENZYME SECRETION
    RUTH FIELD; Fiscal Year: 1992
    ..of secretion of two digestive enzymes, lingual lipase and amylase, from serous (von Ebner's) glands of the tongue. These exocrine glands are the only known source of lingual lipase which is responsible for the first step in ..
  66. AIDS ASSOCIATED LEUKOPLAKIA--ROLE OF EBV
    Nancy Raab Traub; Fiscal Year: 2004
    ..and defective EBV genomes is a frequent occurrence in HLP and that the strains of EBV which are replicating on the tongue in HLP infect the peripheral blood...
  67. ORAL PHARYNGEAL REFLEXES
    Louis Goldberg; Fiscal Year: 1992
    ..long-term objective of this proposal is to determine the neutral basis for the coordination and control of jaw and tongue movements during feeding and drinking...
  68. STUDIES IN ORAL PHARYNGEAL REFLEXES
    Scott Chandler; Fiscal Year: 1993
    ..long-term objective of this proposal is to determine the neutral basis for the coordination and control of jaw and tongue movements during feeding and drinking...
  69. GUSTATORY CHEMOSENSITIVITY OF THE ORAL PALATE
    INGLIS MILLER; Fiscal Year: 1980
    ..buds are present on the oral palates of humans and the human palate is as sensitive to chemical solutions as the tongue. In the rat which is frequently used as an animal model for the study of taste, there are as many taste buds on ..
  70. Respiratory activities of intrinsic tongue muscles
    E Bailey; Fiscal Year: 2004
    b>Tongue movement depends on the actions of both intrinsic (origin and insertion in the tongue) and extrinsic (attached to bone and inserted into the tongue) muscles...
  71. Tongue-Jaw Linkages in Feeding
    Jeffrey Palmer; Fiscal Year: 2005
    ..Movement of food in and through the oral cavity depends primarily on coordinated motions of the jaw, hyoid, and tongue. Although the basic motions have been described, the muscle activity patterns producing these motions have not...
  72. NEUROMOTOR BASIS OF STUTTERING
    MICHAEL MCCLEAN; Fiscal Year: 2003
    ..g., tongue and jaw) are controlled and coordinated...
  73. Linguapalatal Contact Pressures During Speech
    JEFFREY SEARL; Fiscal Year: 2003
    Abnormalities in tongue strength, range of motion, and coordination are primary contributors to speech deficits resulting from stroke, head injury, neuromuscular disease, oral cancer, and developmental delays...
  74. CHORDA-LINGUAL NERVE INJURY AND CHEMOSENSORY PERFORMANCE
    John Zuniga; Fiscal Year: 1993
    ..of different concentrations of citrate applied to spatially- matched, isolated, discrete regions of the anterior tongue tip...
  75. HIV suppression by Beta-defensins
    Alfredo Garzino Demo; Fiscal Year: 2004
    ..Their expression is elevated in the epithelia of the mouth, tongue, digestive apparatus, and also in airways, mammary gland, liver and other organs...
  76. PRECISE CONTOL OF TONGUE MOVEMENT
    Stephen Goldberg; Fiscal Year: 2005
    The normal development of the complex neuromuscular system used to control tongue movement is critical to the immediate survival of all terrestrial mammals...