mouth mucosa

Summary

Summary: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.

Top Publications

  1. ncbi Tobacco use and oral disease
    D M Winn
    Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7395, USA
    J Dent Educ 65:306-12. 2001
  2. ncbi The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, Roma, Italy
    Mutat Res 728:88-97. 2011
  3. pmc Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling
    Gunther Weindl
    Department of Dermatology, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Clin Invest 117:3664-72. 2007
  4. ncbi National prevalence of oral HPV infection and related risk factors in the U.S. adult population
    A E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Oral Dis 18:430-41. 2012
  5. ncbi Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study
    Jie Cao
    Peking University School and Hospital of Stomatology, Beijing, China
    Clin Cancer Res 15:5178-83. 2009
  6. ncbi Lack of type-specific concordance between human papillomavirus (HPV) serology and HPV DNA detection in the uterine cervix and oral mucosa
    A E Paaso
    Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland
    J Gen Virol 92:2034-46. 2011
  7. pmc Antimicrobial peptides in periodontal innate defense
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, USA
    Front Oral Biol 15:84-98. 2012
  8. ncbi Circadian expression of clock- and tumor suppressor genes in human oral mucosa
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 26:155-66. 2010
  9. ncbi Nd:YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa
    Paolo Vescovi
    Department of ENT Dental Ophthalmological and Cervico Facial Sciences, Universita degli Studi di Parma, Parma, Italy
    Lasers Med Sci 25:685-91. 2010
  10. ncbi Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signaling
    Takahiro Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    Stem Cells 25:628-38. 2007

Detail Information

Publications336 found, 100 shown here

  1. ncbi Tobacco use and oral disease
    D M Winn
    Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7395, USA
    J Dent Educ 65:306-12. 2001
    ..Effective treatments to prevent tobacco use and increase cessation are available and need greater implementation. Dental practices may provide a uniquely effective setting for tobacco prevention and cessation...
  2. ncbi The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, Roma, Italy
    Mutat Res 728:88-97. 2011
    ....
  3. pmc Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling
    Gunther Weindl
    Department of Dermatology, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Clin Invest 117:3664-72. 2007
    ....
  4. ncbi National prevalence of oral HPV infection and related risk factors in the U.S. adult population
    A E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Oral Dis 18:430-41. 2012
    ..The results also provide population data that help evaluate the likely public health benefits of prophylactic vaccination against oral HPV acquisition...
  5. ncbi Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study
    Jie Cao
    Peking University School and Hospital of Stomatology, Beijing, China
    Clin Cancer Res 15:5178-83. 2009
    ..To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospective cohort study...
  6. ncbi Lack of type-specific concordance between human papillomavirus (HPV) serology and HPV DNA detection in the uterine cervix and oral mucosa
    A E Paaso
    Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland
    J Gen Virol 92:2034-46. 2011
    ..Neither the presence nor the dynamics of oral HPV DNA had any correlation with HPV serology...
  7. pmc Antimicrobial peptides in periodontal innate defense
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, USA
    Front Oral Biol 15:84-98. 2012
    ..The differential regulation of AMP expression in periodontal disease suggests that AMP panels, including up- and downregulated proteins, can be used in oral fluid diagnosis of periodontal disease and to monitor treatment outcome...
  8. ncbi Circadian expression of clock- and tumor suppressor genes in human oral mucosa
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 26:155-66. 2010
    ..To further elucidate the role circadian clocks have in cellular growth control, tumor suppression and cancer treatment, it is revealing to know how clock genes and clock-controlled genes are regulated in healthy humans...
  9. ncbi Nd:YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa
    Paolo Vescovi
    Department of ENT Dental Ophthalmological and Cervico Facial Sciences, Universita degli Studi di Parma, Parma, Italy
    Lasers Med Sci 25:685-91. 2010
    ..The quality of incision was better and the width of overall tissue injuries was less in the specimens obtained with higher frequency and lower power (group 1: Nd:YAG laser at 3.5 W and 60 Hz)...
  10. ncbi Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signaling
    Takahiro Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    Stem Cells 25:628-38. 2007
    ..Our in vivo and in vitro findings indicate that p75 is a potential marker of oral keratinocyte stem/progenitor cells and that some neurotrophin/p75 signaling affects cell growth and survival...
  11. ncbi Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus
    Kenichi Kumagai
    Department of Oral and Maxillofacial Surgery, Tsurumi University, Tsurumi ku, Yokohama, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:748-54. 2010
    ..This study aimed to investigate the roles of the epidermal growth factor receptor (EGFR) family members and their ligands in oral lichen planus (OLP)...
  12. ncbi Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema
    K Laitinen
    Department of Paediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 36:166-73. 2006
    ..The major theory implicating diet with allergic diseases is associated with altered food consumption and subsequent changes in fatty acid composition...
  13. ncbi Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation
    Tsutomu Inatomi
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Ophthalmol 141:267-275. 2006
    ..To perform a midterm assessment of the integrity and reproducibility of cultivated autologous oral mucosal epithelial sheets, and to evaluate the clinical efficacy of their transplantation in ocular surface...
  14. ncbi Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults
    Helen E Gabriel
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:835-41. 2006
    ..Because folate is instrumental in DNA synthesis and repair, it is a determinant of genetic stability and therefore might attenuate the genotoxic effects of smoking...
  15. ncbi ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p
    Xiaomin Zhao
    Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Microbiology 150:2415-28. 2004
    ..Collectively, these results demonstrate functional similarities and differences between Als1p and Als3p, and suggest the potential for more complex interrelationships between the ALS genes and their encoded proteins...
  16. ncbi Smoking and smokeless tobacco-associated human buccal cell mutations and their association with oral cancer--a review
    Nicole K Proia
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1061-77. 2006
    ....
  17. ncbi Evaluation of micronucleus frequencies and DNA damage in glass workers exposed to arsenic
    Saleha B Vuyyuri
    Department of Genetics, Osmania University, Hyderabad 500007, Andhra Pradesh, India
    Environ Mol Mutagen 47:562-70. 2006
    ..Our findings indicate that chronic occupational exposure to As is genotoxic and that the Comet assay and micronucleus test are useful assays for evaluating genotoxicity in humans occupationally exposed to As...
  18. pmc Differential expression of HIF-1α in skin and mucosal wounds
    L Chen
    Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, 801 S Paulina St, MC 859, Chicago, IL 60612, USA
    J Dent Res 91:871-6. 2012
    ..Interestingly, modulation of oxygen by HBOT does not ameliorate this difference. These results suggest that differential responses to hypoxia may underlie the distinctive wound-healing phenotypes seen in skin and oral mucosa...
  19. ncbi Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids
    Mario Klingler
    Division of Metabolic and Nutritional Medicine, Dr von Hauner Children s Hospital, University of Munich Medical Center, Lindwurmstr 4, 80337, Munich, Germany
    Lipids 46:981-90. 2011
    ..The accuracy and reliability of this new method is comparable to conventional invasive methods for the determination of the n-3 fatty acid status in humans, and it is well applicable in interventional or epidemiological studies...
  20. ncbi Genotoxicity biomarkers in occupational exposure to formaldehyde--the case of histopathology laboratories
    Carina Ladeira
    Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Portugal
    Mutat Res 721:15-20. 2011
    ..011), with drinkers showing higher mean values. These results provide evidence of the association between occupational exposure to formaldehyde and the presence of genotoxicity biomarkers...
  21. ncbi Disruption of sphingolipid biosynthetic gene IPT1 reduces Candida albicans adhesion and prevents activation of human gingival epithelial cell innate immune defense
    Mahmoud Rouabhia
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec, Canada
    Med Mycol 49:458-66. 2011
    ..This is the first study to demonstrate that a disruption of the IPT1 gene affects Candida-host interaction, thus preventing TLR activation and β-defensin expression...
  22. ncbi The upregulation of cystatin C in oral submucous fibrosis
    Tsai Chung-Hung
    Department of Oral Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan
    Oral Oncol 43:680-5. 2007
    ..05). Taken together, the data demonstrate that cystatin C expression is significantly upregulated in OSF from areca quid chewers and arecoline may be responsible for the enhanced cystatin C expression in vivo...
  23. ncbi Differential injury responses in oral mucosal and cutaneous wounds
    A M Szpaderska
    Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA
    J Dent Res 82:621-6. 2003
    ..These findings demonstrate that diminished inflammation is a key feature of the privileged repair of oral mucosa...
  24. ncbi Detection of human immunodeficiency virus type 1 RNA by in situ hybridization in oral mucosa epithelial cells from anti-HIV-1 positive patients
    Elena Rodríguez-Iñigo
    Fundacióon para el estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 77:17-22. 2005
    ....
  25. ncbi The fatty acid profile of buccal cheek cell phospholipids is a noninvasive marker of long-chain polyunsaturated Fatty Acid status in piglets
    Alexandre Lapillonne
    U S Department of Agriculture ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030 2600, USA
    J Nutr 132:2319-23. 2002
    ....
  26. ncbi Site-specific production of TGF-beta in oral mucosal and cutaneous wounds
    Megan E Schrementi
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, Illinois, USA
    Wound Repair Regen 16:80-6. 2008
    ..These findings showed reduced scarring in oral wounds at the ultrastructural level, and provide evidence that site-specific differences in TGF-beta production contributes to the superior healing of oral wounds...
  27. ncbi Making sense of the epithelial barrier: what molecular biology and genetics tell us about the functions of oral mucosal and epidermal tissues
    Richard B Presland
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195 7132, USA
    J Dent Educ 66:564-74. 2002
    ..We also highlight recent work demonstrating how loss or attenuation of certain proteases can lead to early onset periodontitis and tooth loss as well as other epithelial abnormalities...
  28. ncbi The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
    ....
  29. ncbi Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A
    Lays M Sobral
    Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    Oral Oncol 47:840-6. 2011
    ..We conclude that myofibroblasts in the stroma of OSCC may influence proliferation and invasion, resulting in more aggressive tumor...
  30. pmc Microbiomic subprofiles and MDR1 promoter methylation in head and neck squamous cell carcinoma
    Gurkan Bebek
    Genomic Medicine Institute, Lerner Research Institute, Cleveland, OH 44195, USA
    Hum Mol Genet 21:1557-65. 2012
    ....
  31. ncbi Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells
    S L Connor
    Departments of Medicine and Pediatrics, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Am J Clin Nutr 71:21-7. 2000
    ..However, these invasive techniques cannot always be used in studies involving infants, young children, or subjects from whom it is difficult to obtain blood. A body tissue that is easy to access is the buccal mucosa (cheek cells)...
  32. ncbi Association of micronucleus frequency with neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 26:85-92. 2011
    ..These changes in buccal cytome ratios may prove useful as potential future diagnostics to identify individuals of increased risk for these disorders...
  33. ncbi The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis
    Shun Fa Yang
    Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan
    Oral Oncol 39:367-72. 2003
    ..Taken together, these results suggest that PAI-1 expression is significantly upregulated in OSF tissues from areca quid chewers, and arecoline may be responsible for the enhanced PAI-1 expression in vivo...
  34. ncbi Implications of cytokeratin 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype
    Ujwala Raul
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Cancer Research Institute, Kharghar, Navi Mumbai, India
    Int J Cancer 111:662-8. 2004
    ..In both cases, lung metastasis was also seen. Thus, in conclusion, it appears that increased expression of CK8 in some way changes the phenotypic characteristics of stratified epithelial cells, resulting in malignant transformation...
  35. ncbi Oral mucosal lesions in a representative cross-sectional study of aging Germans
    P A Reichart
    Department of Oral Surgery and Oral Radiology Center for Dentistry, University Clinic Charite, Berlin, Germany
    Community Dent Oral Epidemiol 28:390-8. 2000
    ..To determine prevalence of oral mucosal lesions in a cross-sectional study among aging Germans...
  36. ncbi Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal cells
    Simon D Spivack
    Laboratory of Human Toxicology and Molecular Epidemiology, New York State Department of Health, Albany, NY 12201 0509, USA
    Cancer Res 64:6805-13. 2004
    ..This noninvasive and quantitative method may be incorporated into high-throughput human applications for probing gene-environment interactions associated with cancer...
  37. ncbi Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis
    Ponlatham Chaiyarit
    Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand
    Cancer Sci 96:553-9. 2005
    ..We conclude that the formation of potentially mutagenic DNA lesions including 8-nitroguanine and 8-oxodG may contribute to the development of oral cancer from OLP...
  38. pmc Circadian variation in the expression of cell-cycle proteins in human oral epithelium
    G A Bjarnason
    Toronto Sunnybrook Regional Cancer Centre, Department of Medicine, University of Toronto, Ontario, Canada
    Am J Pathol 154:613-22. 1999
    ..The finding of a circadian variation in the nuclear expression of p53 protein corresponding to late G1 is novel. This information has clinical implications regarding the timing of chemotherapy and radiotherapy...
  39. ncbi Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation
    S T Sonis
    Brigham and Women's Hospital and Harvard School of Dental Medicine, Boston, MA, USA
    J Clin Oncol 19:2201-5. 2001
    ..06). CONCLUSION: Oral mucositis is associated with significantly worse clinical and economic outcomes in blood and marrow transplantation...
  40. ncbi Improvement of sublingual immunotherapy efficacy with a mucoadhesive allergen formulation
    Alain Razafindratsita
    Research and Development, Stallergènes, Antony, France
    J Allergy Clin Immunol 120:278-85. 2007
    ..A murine model of sublingual immunotherapy is needed to understand better the immune mechanisms involved in successful immunotherapy and to assess second-generation candidate vaccines...
  41. ncbi Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma
    Takahiro Kiyosue
    Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Int J Clin Oncol 18:154-63. 2013
    ....
  42. ncbi Report on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007
    Michael Fenech
    Mutagenesis 24:199-201. 2009
    ..A follow-up workshop is planned at the 10th International Conference on Environmental Mutagens in Florence in 2009...
  43. ncbi Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model
    Karen Mak
    Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
    J Dermatol Sci 56:168-80. 2009
    ..Currently, there are no accepted predictable treatments to prevent scarring which emphasizes a need for a better understanding of the wound healing and scar formation process...
  44. ncbi Aberrant expression of CD133 and musashi-1 in preneoplastic and neoplastic human oral squamous epithelium and their correlation with clinicopathological factors
    Gokulan Ravindran
    Unit of Biochemistry, Department of Zoology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
    Head Neck 34:1129-35. 2012
    ..The study also aims to investigate the correlation of CD133 and Musashi-1 expression with clinicopathological factors...
  45. pmc Oral mucosal expression of HIV-1 receptors, co-receptors, and alpha-defensins: tableau of resistance or susceptibility to HIV infection?
    C W Cutler
    Periodontal Molecular Immunology Laboratory, Department of Periodontics, School of Dental Medicine, J 110 Rockland Hall, Stony Brook University SUNY, Stony Brook, NY 11794 8703, USA
    Adv Dent Res 19:49-51. 2006
    ....
  46. ncbi Human papillomavirus in oral atrophic lichen planus lesions
    Riikka Mattila
    Department of Oral Pathology and Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Finland
    Oral Oncol 48:980-4. 2012
    ..We assessed HPV-genotype distribution in atrophic OLPs as related to DNA content and repair, proliferation activity, apoptosis, cell adhesion and lymphocyte infiltration...
  47. ncbi Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts
    Wei Feng Ni
    Institute of Stomatology, Chung Shan Medical University, Taichung, Taiwan
    Oral Oncol 43:557-62. 2007
    ..NF-kappaB expression induced by safrole in fibroblasts may be mediated by ERK activation and COX-2 signal transduction pathway...
  48. ncbi Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate
    N Titenko-Holland
    Division of Environmental Health Sciences, 217 Warren Hall, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Mutat Res 417:101-14. 1998
    ..010). Thus, low folate, without clinical symptoms of anemia, results in higher levels of cytogenetic damage in both the blood and oral cavity of postmenopausal women...
  49. ncbi Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids
    Mario Klingler
    Division of Metabolic and Nutritional Medicine, University of Munich Medical Center, Dr von Hauner Children s Hospital, Lindwurmstrasse 4, 80337 Munich, Germany
    Br J Nutr 109:962-8. 2013
    ..Based on the data of the present study, they can be used alternatively to plasma and erythrocyte PL as non-invasive n-3 fatty acid status markers...
  50. ncbi Streptococcal adhesion and colonization
    H F Jenkinson
    Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand
    Crit Rev Oral Biol Med 8:175-200. 1997
    ....
  51. ncbi Micronucleus frequencies in lymphocytes and buccal epithelial cells from patients having head and neck cancer and their first-degree relatives
    Sema Burgaz
    Toxicology Department, Pharmacy Faculty, Gazi University, 06330 Ankara, Turkey
    Mutagenesis 26:351-6. 2011
    ..05), thus reflecting an increased susceptibility to HNC in FDRs. However, for buccal cell MN frequencies, we could not demonstrate enhanced genetic instability in the FDRs of patients having HNC...
  52. pmc Human oral mucosa and gingiva: a unique reservoir for mesenchymal stem cells
    Q Z Zhang
    Department of Oral and Maxillofacial Surgery and Pharmacology, Penn Dental Medicine and Penn Medicine Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Dent Res 91:1011-8. 2012
    ..The ease of isolation, accessible tissue source, and rapid ex vivo expansion, with maintenance of stable stem-cell-like phenotypes, render oral mucosa- and gingiva-derived MSCs a promising alternative cell source for MSC-based therapies...
  53. pmc Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status
    Alex J Walsh
    Vanderbilt University, Department of Biomedical Engineering, Station B, Box 1631, Nashville, Tennessee 37235, USA
    J Biomed Opt 17:116015. 2012
    ..This study suggests that short-term ex vivo tissue culture may be more appropriate than frozen-thawed tissue for optical metabolic and morphologic measurements that approximate in vivo status...
  54. ncbi beta-catenin expression pattern in primary oral squamous cell carcinoma
    Zhi Gang Cai
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
    Chin Med J (Engl) 121:1866-70. 2008
    ....
  55. ncbi Oral mucositis complicating chemotherapy and/or radiotherapy: options for prevention and treatment
    W J Köstler
    Clinical Division of Oncology, Department of Medicine I, University Hospital of Vienna, Austria
    CA Cancer J Clin 51:290-315. 2001
    ..The prophylactic and therapeutic armamentarium for the treatment of oral mucositis consists of locally and systemically applied nonpharmacological measures and pharmacotherapeutics...
  56. ncbi Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ
    Toshihiko Mikami
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Oncol 47:497-503. 2011
    ..The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies...
  57. ncbi Induction of epithelial migration of lymphocytes by intercellular adhesion molecule-1 in a rat model of oral mucosal graft-versus-host disease
    Jun Ohno
    Department of Morphological Biology, Pathology Section, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka, Japan
    Histol Histopathol 26:725-33. 2011
    ..Our data suggest that in the early phase of acute oral mucosal GVHD, the induction of ICAM-1 expression on KCs leads to the migration of CD8+ cells into the epithelium and that this is mediated in part by the ICAM-1/LFA-1 pathway...
  58. ncbi Direct thickness measurements of the hard palate mucosa
    Beate Schacher
    Department of Periodontology, Hospital of the Johan Wolfgang Goethe University Frankfurt Main, Frankfurt, Germany
    Quintessence Int 41:e149-56. 2010
    ..To measure directly the thickness of the palatal mucosa using sharp cannulas and to evaluate potential correlations with gender and body mass index (BMI)...
  59. ncbi Increased micronucleus frequency in exfoliated cells of the buccal mucosa in hairdressers
    L N Rickes
    Laboratorio de Genetica, Centro de Ciências da Vida e da Saúde, Universidade Catolica de Pelotas, Pelotas, RS, Brasil
    Genet Mol Res 9:1921-8. 2010
    ..033) in females. The lowest income level influenced MNC (P = 0.044), and the habit of not smoking influenced SA (P = 0.020). We concluded that exposure to substances used by hairdressers is genotoxic for men...
  60. ncbi Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management
    Isaac van der Waal
    Department of Oral and Maxillofacial Surgery Pathology, VU University Medical Center Academic Centre for Dentistry Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 46:423-5. 2010
    ..At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable...
  61. ncbi The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future
    Michael Fenech
    Department of Nutritional Genomics and DNA Damage Diagnostics, Commonwealth Scientific and Industrial Research Organisation Food and Nutritional Sciences, Adelaide BC, South Australia 5000, Australia
    Mutagenesis 26:239-45. 2011
    ..g. erythrocyte and nasal cells and (iv) prospective association studies with pregnancy complications, developmental defects, childhood cancers, cardiovascular disease and neurodegenerative diseases...
  62. ncbi Morphogenesis of rete ridges in human oral mucosa: a pioneering morphological and immunohistochemical study
    Tianfu Wu
    The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, PR China
    Cells Tissues Organs 197:239-48. 2013
    ....
  63. ncbi Characterization of oral keratinocyte stem cells and prospects of its differentiation to oral epithelial equivalents
    B Calenic
    Department of Oral Health, Nippon Dental University, Tokyo, Japan
    Rom J Morphol Embryol 51:641-5. 2010
    ..The specific aim of the present study is to characterize an oral keratinocyte stem-cell population separated using a magnetic technique...
  64. pmc Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes
    Shahinaz M Gadalla
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Aging (Albany NY) 2:867-74. 2010
    ..66, p=0.002), blood and buccal cells (r=0.74, p<0.0001), and fibroblast and buccal cells (r=0.65, p=0.004). These data suggest that relative TL is tissue-independent in DC and possibly in the other IBMFS...
  65. pmc Positional differences in the wound transcriptome of skin and oral mucosa
    Lin Chen
    Center for Wound Healing and Tissue Regeneration, University of Illinois, Chicago, IL, USA
    BMC Genomics 11:471. 2010
    ..The current study was designed to compare the transcriptomes of oral mucosal and skin wounds in order to identify critical differences in the healing response at these two sites using an unbiased approach...
  66. ncbi Orotransmucosal drug delivery systems: a review
    N V Satheesh Madhav
    Faculty of Pharmacy, Dehradoon Institute of Technology, Mussorie Diversion Road, Bagawantpur, Makkawala, Uttarakhand 248009 Dehradoon, India
    J Control Release 140:2-11. 2009
    ..The present papers intend to overview a wide range of orotransmucosal routes being potentially useful for transmucosal drug delivery and remind us of the success achieved with these systems and the latest advancement in the field...
  67. pmc Characterization of mucosal Candida albicans biofilms
    Anna Dongari-Bagtzoglou
    Division of Periodontology, School of Dental Medicine, University of Connecticut, Farmington, Connecticut, United States of America
    PLoS ONE 4:e7967. 2009
    ....
  68. ncbi High-risk types of human papillomavirus (HPV) DNA in oral and genital mucosa of infants during their first 3 years of life: experience from the Finnish HPV Family Study
    Marjut A M Rintala
    Department of Obstetrics and Gynecology, Turku University Hospital, Turku, Finland
    Clin Infect Dis 41:1728-33. 2005
    ..This study is aimed to clarify data on the acquisition, persistence, and clearance of high-risk types of human papillomavirus (HPV) DNA from the mucosa and the determinants of persistent mucosal HPV infection in infants...
  69. ncbi Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo
    Marie Le Borgne
    INSERM U404 Immunité et Vaccination, IFR128 Biosciences Lyon Gerland, F 69365 Lyon, France
    Immunity 24:191-201. 2006
    ..Thus, newly recruited DCs likely derived from circulating monocytes are responsible for efficient crosspriming of CD8+ CTL after mucosal or skin immunization...
  70. pmc A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells
    David L Moyes
    Department of Oral Medicine, Pathology, and Immunology, King s College London Dental Institute, King s College London, London, UK
    Cell Host Microbe 8:225-35. 2010
    ..MAPK/MKP1/c-Fos activation may represent a "danger response" pathway that is critical for identifying and responding to the pathogenic switch of commensal microbes...
  71. ncbi The upregulation of insulin-like growth factor-1 in oral submucous fibrosis
    Chung Hung Tsai
    Department of Oral Pathology, Chung Shan Medical University, Taichung, Taiwan, ROC
    Oral Oncol 41:940-6. 2005
    ..05). Taken together, the data presented here demonstrated that IGF-1 expression is significantly upregulated in OSF from areca quid chewers and arecoline may be responsible for the enhanced IGF-1 expression in vivo...
  72. ncbi Alteration of cell-cycle regulatory proteins in human oral epithelial cells immortalized by HPV16 E6 and E7
    P Sdek
    School of Stomatology, Shanghai Second Medical University, 639 Zhi Zao Ju Road, Shanghai 200011, PR China
    Int J Oral Maxillofac Surg 35:653-7. 2006
    ..This suggests that the pathogenesis of HPV in oral epithelial cells differs from that in cervical epithelial cells...
  73. ncbi Trehalose inhibits oral dryness by protecting the cell membrane
    Y Mori
    Sensory and Motor System Medicine, Faculty of Medicine, Japan
    Int J Oral Maxillofac Surg 39:916-21. 2010
    ..These results indicate that pretreatment application of trehalose solution on the oral mucosa is effective in preventing oral dryness caused by dental treatment...
  74. ncbi The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes
    M J McCullough
    Melbourne Dental School, The University of Melbourne, Victoria
    Aust Dent J 53:302-5. 2008
    ....
  75. ncbi Mechanisms of sublingual immunotherapy
    Guy Scadding
    Allergy and Clinical Immunology, Imperial College, London, UK
    J Asthma 46:322-34. 2009
    ..This review discusses the possible mechanism of action of sublingual immunotherapy, including data from animal and clinical studies, while comparing this with the current understanding of subcutaneous immunotherapy...
  76. ncbi Effective indicators for diagnosis of oral cancer using optical coherence tomography
    Meng Tsan Tsai
    Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei, Taiwan
    Opt Express 16:15847-62. 2008
    ..It is found that SD and alpha are good diagnosis indicators for moderate dysplasia and squamous cell carcinoma. On the other hand, T is a good diagnosis indicator for epithelia hyperplasia and moderate dysplasia...
  77. ncbi Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells
    Laurent Mascarell
    Research and Development, Stallergenes SA, Antony, France
    J Allergy Clin Immunol 122:603-9.e5. 2008
    ..A detailed characterization of oral antigen-presenting cells is critical to improve second-generation sublingual allergy vaccines...
  78. ncbi The immune privilege of the oral mucosa
    Natalija Novak
    Department of Dermatology and Allergy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Trends Mol Med 14:191-8. 2008
    ....
  79. ncbi The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR
    David Esquenazi
    Universidade Federal do Rio de Janeiro, Brazil
    Braz J Otorhinolaryngol 76:78-84. 2010
    ..In the oral mucosa they have been associated with oral papilloma, focal epithelial hyperplasia, leucoplakia and oral neoplasia...
  80. ncbi Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata
    Pirjo Pärnänen
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    J Oral Pathol Med 39:275-8. 2010
    ..E-cadherin (E-Cad) is a 120-kDa adhesive protein found in adherens junctions of the digestive tract epithelium. We tested the ability of two Candida strains to degrade human E-Cad in the Candida virulence factor perspective...
  81. ncbi Treatment of Laugier-Hunziker syndrome with the Q-switched alexandrite laser in 22 Chinese patients
    Ya Gang Zuo
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Arch Dermatol Res 302:125-30. 2010
    ..Our study has also demonstrated QSAL to be highly effective and safe in the treatment of LHS...
  82. ncbi Screening and analysis of pathogenic genes during DMBA-induced buccal mucosa carcinogenesis in golden hamsters
    Kai Yang
    Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China
    Oncol Rep 23:1619-24. 2010
    ..Searching for various effective inhibitors of xenobiotic metabolism by cytochrome P450 and the arachidonic acid metabolism pathway may suggest a therapy for the treatment and chemoprevention of oral squamous cell carcinoma...
  83. ncbi Candida albicans induces early apoptosis followed by secondary necrosis in oral epithelial cells
    C C Villar
    Department of Periodontics, The University of Texas, Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Mol Oral Microbiol 25:215-25. 2010
    ..Hence, C. albicans stimulates oral epithelial signaling pathways that promote early apoptotic cell death through the activation of cellular caspases, followed by late necrosis...
  84. ncbi Quality of life and psychological problems of patients with oral mucosal disease in dermatological practice
    S Tabolli
    Health Services Research Unit, IDI IRCCS, Via dei Monti di Creta, 104 Rome IT 00167, Italy
    Dermatology 218:314-20. 2009
    ..Dermatologists see patients with oral mucosal conditions...
  85. ncbi Laugier-Hunziker-Baran syndrome
    Kaori Yago
    Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:e20-5. 2008
    ..The differential diagnosis of oral and pigmented lesions between Laugier-Hunziker-Baran syndrome and other disorders, Peutz-Jeghers syndrome in particular, requires our utmost consideration...
  86. ncbi Natural history of oral papillomavirus infections in spouses: a prospective Finnish HPV Family Study
    Marjut Rintala
    Department of Obstetrics and Gynecology, Turku University Central Hospital, P O Box 52, FIN 20521 Turku, Finland
    J Clin Virol 35:89-94. 2006
    ..The natural history of genital human papillomavirus infection is well known, but nearly nothing is known about the outcome of oral HPV-infection...
  87. ncbi Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas
    M A Onofre
    Oral Medicine Service, Department of Diagnosis and Surgery, School of Dentistry Araraquara UNESP, Sao Paulo, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:535-40. 2001
    ....
  88. ncbi Laugier-Hunziker syndrome: a rare cause of mucocutaneous pigmentation
    T Sabesan
    Department of Oral and Maxillofacial Surgery, Poole General Hospital, Longfleet Road, Poole, Dorset BH15 2JB, UK
    Br J Oral Maxillofac Surg 44:320-1. 2006
    ..An 80-year-old white woman presented with brown pigmentation on both sides of the buccal mucosa and lower lip and patchy freckling in her nails, which was diagnosed as Laugier-Hunziker syndrome...
  89. ncbi Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Frauenlobstr 9 11, D 80337 Munich, Germany
    Microbiology 150:2807-13. 2004
    ..albicans, as well as the influence of PMNs on C. albicans pathogenesis...
  90. ncbi ERBB receptors in developing, dysplastic and malignant oral epithelia
    J Rautava
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520, Turku, Finland
    Oral Oncol 44:227-35. 2008
    ..This information may be useful for clinicians as EGFR inhibitors are becoming treatment options in modern oncology...
  91. ncbi Immune mechanisms in oral lichen planus
    M H Thornhill
    Oral Disease Research Centre, Bart s and The London, Queen Mary School of Medicine and Dentistry, UK
    Acta Odontol Scand 59:174-7. 2001
    ..In susceptible individuals, chronic presentation of antigen by basal keratinocytes may perpetuate the condition and direct cell-mediated immune damage on the keratinocytes...
  92. ncbi Histological grading of oral epithelial dysplasia: revisited
    S Warnakulasuriya
    Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College London, Denmark Hill Campus, Caldecot Road, London, UK
    J Pathol 194:294-7. 2001
    ..They are potential biomarker candidates but their utility in prognosis of oral precancer deserves further study...
  93. ncbi Laugier-Hunziker syndrome associated with actinic lichen planus
    S Aytekin
    J Eur Acad Dermatol Venereol 18:221-3. 2004
  94. ncbi Successful genome-wide scan in paired blood and buccal samples
    Heather Spencer Feigelson
    Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road, NE, Atlanta, GA, USA
    Cancer Epidemiol Biomarkers Prev 16:1023-5. 2007
    ..96%). These results show that buccal cell samples collected and processed under optimal conditions can be used for genome-wide association studies with results comparable to those obtained from DNA extracted from buffy coat...
  95. ncbi Idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a report of a case
    Maria Siponen
    Univeristy of Oulu, Oulu University Hospital, Oulu, Finland
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:288-92. 2003
    ..Here we report the first case of the Laugier-Hunziker syndrome in Scandinavia. Other conditions causing diffuse or multifocal pigmented oral lesions are discussed...
  96. ncbi Frequency of oral conditions in a dermatology clinic
    V A Ramirez-Amador
    Department of Health Care, Universidad Autonoma Metropolitana Xochimilco, Consejo Nacional para la prevencion y control del SIDA, Mexico City, Mexico
    Int J Dermatol 39:501-5. 2000
    ..Oral mucosal manifestations may be the initial feature, the most florid clinical feature, or the only sign of mucocutaneous diseases...
  97. ncbi Laser microdissection separation of pure spermatozoa from epithelial cells for short tandem repeat analysis
    Christine T Sanders
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    J Forensic Sci 51:748-57. 2006
    ..This report describes an efficient, low-manipulation LMD method for the efficient separation of spermatozoa from two-donor sperm/epithelial cell mixtures...
  98. pmc Deletion of ALS5, ALS6 or ALS7 increases adhesion of Candida albicans to human vascular endothelial and buccal epithelial cells
    Xiaomin Zhao
    Department of Pathobiology, University of Illinois, Urbana, Illinois 61802, USA
    Med Mycol 45:429-34. 2007
    ..These studies demonstrate similar phenotypic characteristics for the als5Delta/als5Delta, als6Delta/als6Delta and als7Delta/als7Delta strains that are not observed in any of the other C. albicans alsDelta/alsDelta isolates...
  99. ncbi Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy?
    J P Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 63:720-7. 2008
    ..As little is known about LCs and MCs within the oral cavity, we investigated their distribution in search for mucosal sites with highest LCs and lowest MCs density...
  100. ncbi DNA aneuploidy and dysplasia in oral potentially malignant disorders: association with cigarette smoking and site
    Monica Pentenero
    Department of Clinical and Biological Sciences, Oral Medicine and Oral Oncology Section, University of Turin, Regione Gonzole 10, 10043 Orbassano TO, Italy
    Oral Oncol 45:887-90. 2009
    ..Moreover DNA FCM of these samples appears easy amenable to routine analysis. Further research on larger numbers of PMDs should be carried out to determine whether DNA FCM plays a role in the prediction of risk of PMD transformation...
  101. ncbi Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1
    Akiko Uehara
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Immunol 177:1796-804. 2006
    ....

Research Grants70

  1. Creation of adult epithelial stem cells from differentiated epithelial
    Robert A Weinberg; Fiscal Year: 2010
    ..We believe that this strategy can be applied to many epithelial tissues, such as the skin or mouth mucosa.
  2. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  3. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  4. Chemoprevention of Oral Dysplasia by Black Raspberries
    Susan Mallery; Fiscal Year: 2005
    ..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
  5. Genes of M. tuberculosis Induced During Human Infection
    Jeffrey Hillman; Fiscal Year: 2004
    ..abstract_text> ..
  6. INNATE INTRAEPITHELIAL DEFENSE AGAINST ORAL INFECTION
    MARK HERZBERG; Fiscal Year: 2006
    ..abstract_text> ..
  7. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  8. Identification of Novel Genes Expressed in Bowel Cancer Using Change Mediated Ant
    Jeffrey Hillman; Fiscal Year: 2007
    ..Such proteins are likely to be useful in monitoring treatment, diagnosing this disease, and in preventing it. [unreadable] [unreadable] [unreadable]..
  9. ORAL MUCOSITIS - FORMULATIONS FOR PALLIATION AND THERAPY
    Christopher Squier; Fiscal Year: 2002
    ....
  10. Adiponectin in Human Milk and Infant Serum in Relation to Early Adiposity
    Jessica Woo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  12. SMALL BIOEFFECTOR MOLECULES OF STREPTOCOCCUS MUTANS
    Jeffrey Hillman; Fiscal Year: 2001
    ..In specific aim 5, a reporter gene-labeled construct of JH1140 will be mutagenized with Tn917 and mutants lacking positive regulators for mutacin 1140 expression will be isolated and analyzed. ..
  13. Bisphosphonates and Oral Complications of Cancer Chemotherapy: A Pilot Study
    Regina Landesberg; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  15. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  16. Tobacco Carcinogen Oral Cancer Model
    Joel Schwartz; Fiscal Year: 2005
    ..lc. Assessments of membrane (aryl hydrolase) and cytoplasmic phase I and II enzymes. ld. Confirmation of early cellular initiation and promotion events critical to our understanding for prevention of oral cancer. ..
  17. Host Response and Pathogenesis in the Oral Cavity during SIV Infection
    Michael George; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. Focusing oral health research at the University of Iowa
    Christopher Squier; Fiscal Year: 2003
    ..abstract_text> ..
  19. Oral Epithelial Cells: Innate Immune "Gatekeeper" of HIV
    MARK HERZBERG; Fiscal Year: 2006
    ..Innate immune factor-related genes may prove to be novel targets to prevent mucosal HIV. ..
  20. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
    Susan Mallery; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  21. Biofilm Chemoprevention of Head/Neck Skin Cancer
    Zhi Wang; Fiscal Year: 2005
    ..This is the first study to use polymer biofilm technique for NMSC chemoprevention on head/neck region. We believe that a successful study will greatly benefit patients. ..
  22. Imaging Evaluation of Cancer Chemoprevention
    Zhi Wang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. Laser Atraumatic Treatment of Ectasias on Vocal Cords
    Zhi Wang; Fiscal Year: 2006
    ..It would be safe and convenient enough for an out-patient treatment, without requiring a general anesthesia. [unreadable] [unreadable]..
  24. S. sanguis Adhesion: Molecular Basis of Specificity
    MARK HERZBERG; Fiscal Year: 2009
    ..abstract_text> ..
  25. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
  26. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  27. EBV and HPV: Oral Infection, Persistence & Pathogenesis
    DENNIS WALLING; Fiscal Year: 2003
    ..abstract_text> ..
  28. EBV PATHOGENESIS IN HIV-ASSOCIATED HAIRY LEUKOPLAKIA
    DENNIS WALLING; Fiscal Year: 2003
    ..The results of this study will elucidate molecular mechanisms of EBV pathogenesis in HLP applicable to other EBV-associated diseases, including nasopharyngeal carcinoma and HIV-associated lymphomas. ..
  29. Afro-Caribbean Consortium on viral and environmental risk factors for cancer
    Camille Ragin; Fiscal Year: 2007
    ..We have already had commitments from several investigators who are interested in participating in this Consortium. In total we estimate approximately 60-100 attendees. [unreadable] [unreadable] [unreadable] [unreadable]..
  30. Planning Grant for a Study of the Effect of Radiation o*
    Camille Ragin; Fiscal Year: 2006
    ....
  31. In Vitro Skin Model for Percutaneous Absorption Studies
    Mitchell Klausner; Fiscal Year: 2002
    ..In addition, the methodology developed will likely improve cultured skin graft material since it has ben reported that skin tissue with improved barrier properties increases the efficacy of such grafts. ..
  32. HIV AND STIS IN YOUNG ADULTS: A NETWORK APPROACH
    W Morris; Fiscal Year: 2003
    ..The goal of these analyses will be to identify the relative contribution of individual attributes and network exposure to the risk of infection, and to establish the implications for prevention. ..
  33. 8th ASM Conference on Candida and Candidiasis
    Paul Fidel; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  34. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  35. CORE FACILITY RESEARCH PEPTIDE SYNTHESIZER
    Michael Yeaman; Fiscal Year: 2001
    ..Therefore, the proposed instrument will significantly enhance the efficiency and diversity of SPPS required for NIH-sponsored and hypothesis-driven research. ..
  36. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  37. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2004
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  38. Bacteria-host cell interactions in periodontal disease
    Gill Diamond; Fiscal Year: 2005
    ..The result from this study will allow us to develop novel strategies to prevent attachment and colonization of disease-causing bacteria. ..
  39. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  40. Human Tissue Model For Heterosexual HIV Transmission
    Mitchell Klausner; Fiscal Year: 2003
    ..Protocols for irritation studies will be finalized and the mechanisms of HIV infection and transmission in the tissue will be delineated. Finally, methodology for testing HIV microbicides will be developed. ..
  41. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  42. Clinical and Molecular Evaluation of Cancer Therapy Induced Mucositis
    Sharon Gordon; Fiscal Year: 2007
    ..Demonstration of safety and tolerability will provide a basis to test further this route of administration. Hence, this proposal holds promise for clinical application in a relatively short period. [unreadable] [unreadable]..
  43. Phase I and Biological Studies of DB67 - A Blood Stable Camptothecin
    Markos Leggas; Fiscal Year: 2008
    ..Ultimately, the objective is to use DB-67 as a single agent or in combination with other molecular-targeted therapies or cytotoxics in frontline therapy with the goal to improve overall patient outcome. ..
  44. Regulation of Beta-Defensin Expression in Oral Epithelia
    WHASUN CHUNG; Fiscal Year: 2009
    ..These studies will lead to new insights on the role of innate immunity and new potential targets for therapeutic drug development for oral infections. ..
  45. Novel Context-Activated Protide Anti-Infectives
    Michael Yeaman; Fiscal Year: 2008
    ..These advances would represent major breakthroughs in the prevention and treatment of these common and increasingly difficult-to-treat infections. [unreadable] [unreadable] [unreadable]..
  46. Course and risk factors for depression in late life
    Hillary R Bogner; Fiscal Year: 2010
    ....
  47. Oral Commensal Bacterial Modulation of the Periodontal Innate Host Response
    RICHARD PETERS DARVEAU; Fiscal Year: 2010
    ....
  48. Highly Differentiated Tissue Culture Models of Melanoma
    Mitchell Klausner; Fiscal Year: 2002
    ..The tissues will be characterized in terms of morphology, tumor progression, and adhesion receptors. Finally, reproducibility of the tissue models will be investigated. ..
  49. TREATMENT RESPONSE MARKERS IN ADVANCED LARYNGEAL CANCER
    Carol Bradford; Fiscal Year: 2003
    ..The information acquired in this work should result in new trials that employ predictive markers to select the most appropriate and effective treatment for advanced laryngeal cancer. ..
  50. Regulation of Human Beta-Defensins in Epithelia
    WHASUN CHUNG; Fiscal Year: 2006
    ..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
  51. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  52. Quantifying HIV Transmission Risk in Sex/Drug Networks
    W Morris; Fiscal Year: 2006
    ..It will enable public health professionals to identify population-level prevention strategies that make a network less vulnerable to spread. Moreover, it will identify the type of network data needed to inform such efforts. ..
  53. Biology,Prevention,and Treatment of Head & Neck Cancer
    Carol Bradford; Fiscal Year: 2006
    ..The Workshops are of utmost importance for research progress in head and neck cancer biology, therapy and prevention and progress contributing to the public health. [unreadable] [unreadable]..
  54. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  55. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  56. ORAL IMMUNE DYSFUNCTION AND CANDIDIASIS IN HIV INFECTION
    Paul Fidel; Fiscal Year: 2007
    ..abstract_text> ..
  57. An In Vitro Model of Cell-Associated HIV-1 Transmission
    Deborah Anderson; Fiscal Year: 2006
    ....
  58. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007
    ..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..
  59. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  60. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  61. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    ..This would include strategies to modulate the endogenous antimicrobial peptide expression to prevent serious bacterial infections. ..
  62. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2002
    ....
  63. Biomimetics for Dentin Regeneration
    R Rutherford; Fiscal Year: 2003
    ..If successful these experiments could lead to efficacy tests in non-human primate models of reparative dentinogenesis (Phase II), human clinical trials and commercialization. ..
  64. LBP/CD14 interactions with bacterial components
    Richard Darveau; Fiscal Year: 2005
    ..These studies will provide further insight into how the innate host defense system recognizes and responds to different bacteria, a key component of both oral health and disease. ..
  65. Mechanisms of prion transport
    RICHARD BESSEN; Fiscal Year: 2008
    ..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion transmission. ..
  66. Nod1: An Apaf-like Activator of Apoptosis and NF-kB
    Naohiro Inohara; Fiscal Year: 2005
    ..We propose three Specific Aims to understand the biochemical mechanism by which bacterial LPS and Nod1 interact and to determine the role of Nod1 in the response to bacterial LPS in vivo. ..
  67. P. gingivalis lipid A species modulation of endothelial cell gene activation prog
    Richard Darveau; Fiscal Year: 2007
    ..gingivalis interactions with TLR4 or other novel LPS receptors. Furthermore, the microarray analysis results will be made public by deposition at the European Bioinformatics Institute Array Express database. [unreadable] [unreadable]..
  68. Adherence to Depression Treatment Among Older Patients
    Hillary Bogner; Fiscal Year: 2007
    ..This project will set the stage for the development and implementation of interventions to improve depression treatment adherence among persons with co-existing CVD. ..
  69. ASM Conf. on Beneficial Microbial Symbionts in Animals
    Richard Darveau; Fiscal Year: 2005
    ..It is an intellectually stimulating subject that attracts pioneering graduate students and post-doctoral fellows who will benefit from participation in a focused and dynamic conference; ..