tooth germ

Summary

Summary: The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)

Top Publications

  1. ncbi Tooth development: 1. Generating teeth in the embryo
    Maisa Seppala
    Department of Orthodontics and Craniofacial Development, Floor 22 Guy s Hospital, GKT Dental Institute, King s College London, London SE1 9RT, UK
    Dent Update 33:582-4, 586-8, 590-1. 2006
  2. pmc MicroRNAome and expression profile of developing tooth germ in miniature pigs
    Ang Li
    Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China
    PLoS ONE 7:e52256. 2012
  3. ncbi Early morphogenesis of heterodont dentition in minipigs
    Jan Stembírek
    Institute of Animal Physiology and Genetics, v v i, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Eur J Oral Sci 118:547-58. 2010
  4. ncbi Podoplanin expression in human tooth germ tissues and cystic odontogenic lesions: an immunohistochemical study
    Jozef Zustin
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Germany
    J Oral Pathol Med 39:115-20. 2010
  5. ncbi Generation of a bioengineered tooth by using a three-dimensional cell manipulation method (organ germ method)
    Masamitsu Oshima
    Tokyo University of Science, Chiba, Japan
    Methods Mol Biol 887:149-65. 2012
  6. ncbi Early regression of the dental lamina underlies the development of diphyodont dentitions
    M Buchtová
    Institute of Animal Physiology and Genetics, v v i, Academy of Sciences of the Czech Republic, Veveri 97, 602 00 Brno, Czech Republic
    J Dent Res 91:491-8. 2012
  7. ncbi Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 211:256-68. 1998
  8. ncbi Bioengineered teeth from cultured rat tooth bud cells
    M T Duailibi
    University Federal of São Paulo, Department of Otorhinolaryngology and Human Communication Disorders, Sao Paolo, Brazil
    J Dent Res 83:523-8. 2004
  9. ncbi Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis
    M E Yalvac
    Department of Genetics and Bioengineering, College of Engineering and Architecture, Yeditepe University, Kayisdagi, Istanbul, Turkey
    Pharmacogenomics J 10:105-13. 2010
  10. ncbi Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell-conditioned medium
    Na Huo
    Department of Orthodontics, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Stem Cells Dev 19:93-104. 2010

Research Grants

Detail Information

Publications243 found, 100 shown here

  1. ncbi Tooth development: 1. Generating teeth in the embryo
    Maisa Seppala
    Department of Orthodontics and Craniofacial Development, Floor 22 Guy s Hospital, GKT Dental Institute, King s College London, London SE1 9RT, UK
    Dent Update 33:582-4, 586-8, 590-1. 2006
    ....
  2. pmc MicroRNAome and expression profile of developing tooth germ in miniature pigs
    Ang Li
    Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China
    PLoS ONE 7:e52256. 2012
    ....
  3. ncbi Early morphogenesis of heterodont dentition in minipigs
    Jan Stembírek
    Institute of Animal Physiology and Genetics, v v i, Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Eur J Oral Sci 118:547-58. 2010
    ..After the primary tooth germ reached the late bell stage, the dental lamina began to disintegrate and fragmentize...
  4. ncbi Podoplanin expression in human tooth germ tissues and cystic odontogenic lesions: an immunohistochemical study
    Jozef Zustin
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Germany
    J Oral Pathol Med 39:115-20. 2010
    Podoplanin expression was described in mouse tooth germ and apical bud cells. The aim of this study was to analyse the podoplanin expression of human tooth germ tissues, adult teeth and odontogenic lesions immunohistochemically.
  5. ncbi Generation of a bioengineered tooth by using a three-dimensional cell manipulation method (organ germ method)
    Masamitsu Oshima
    Tokyo University of Science, Chiba, Japan
    Methods Mol Biol 887:149-65. 2012
    ..Here, we describe protocols for tooth germ reconstitution using the organ germ method and methods for analyzing tooth development in vitro and in vivo.
  6. ncbi Early regression of the dental lamina underlies the development of diphyodont dentitions
    M Buchtová
    Institute of Animal Physiology and Genetics, v v i, Academy of Sciences of the Czech Republic, Veveri 97, 602 00 Brno, Czech Republic
    J Dent Res 91:491-8. 2012
    ..The uncovering of the processes behind lamina degradation allows us to clarify the evolution of diphyodonty, and provides a mechanism for future manipulation of the number of tooth generations...
  7. ncbi Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 211:256-68. 1998
    ..The coexpression of Fgfs with other signaling molecules including Shh and several Bmps and their partly similar effects suggest that the FGFs participate in the signaling networks during odontogenesis...
  8. ncbi Bioengineered teeth from cultured rat tooth bud cells
    M T Duailibi
    University Federal of São Paulo, Department of Otorhinolaryngology and Human Communication Disorders, Sao Paolo, Brazil
    J Dent Res 83:523-8. 2004
    ..Furthermore, our ability to bioengineer tooth structures from cultured tooth bud cells suggests that dental epithelial and mesenchymal stem cells can be maintained in vitro for at least 6 days...
  9. ncbi Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis
    M E Yalvac
    Department of Genetics and Bioengineering, College of Engineering and Architecture, Yeditepe University, Kayisdagi, Istanbul, Turkey
    Pharmacogenomics J 10:105-13. 2010
    ..In this study, we isolated and characterized human tooth germ stem cells (hTGSCs) from third molars and assessed the expression of developmentally important transcription ..
  10. ncbi Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell-conditioned medium
    Na Huo
    Department of Orthodontics, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Stem Cells Dev 19:93-104. 2010
    ..By exposure to conditioned medium of embryonic and neonatal tooth germ cells in culture, the proliferation and mineralization activity of DMCs was elevated, while the embryonic tooth ..
  11. ncbi Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray
    K Heikinheimo
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    J Dent Res 81:525-30. 2002
    ..The gene expression profile identifies candidate genes that may be involved in the origination of ameloblastoma and several genes previously unidentified in relation to human tooth development...
  12. ncbi GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts
    Michelle Tillmann Biz
    Department of Cell and Developmental Biology, University of Sao Paulo, Sao Paulo, SP, Brazil
    Cell Tissue Res 340:459-70. 2010
    ..odontoblasts, Rac1 and its effector Pak3 were observed in ameloblasts; and Cdc42 was present in all cells of the tooth germ and mesenchyme...
  13. ncbi Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ
    Y Zhang
    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
    Dev Dyn 215:45-53. 1999
    We have used the mouse developing tooth germ as a model system to explore the transmission of Sonic hedgehog (Shh) signal in the induction of Patched (Ptc)...
  14. ncbi Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro
    Kevin Tompkins
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Bone Miner Res 20:341-9. 2005
    ..Our results show that these individual proteins have specific but quite different effects on epithelial-derived ameloblasts versus mesenchymal-derived odontoblasts...
  15. ncbi Extraction of "killer" teeth: the case of two Somali siblings
    Marcio A da Fonseca
    Section of Pediatric Dentistry, The Ohio State University, Nationwide Children s Hospital, Columbus, Ohio, USA
    J Dent Child (Chic) 74:143-6. 2007
    ..The purpose of this manuscript was to discuss the case of two Somali siblings who had tooth buds enucleated at a young age, leading to significant dental problems...
  16. ncbi Human tooth germ stem cells preserve neuro-protective effects after long-term cryo-preservation
    Mehmet E Yalvac
    Department of Genetics and Bioengineering, College of Engineering and Architecture, Yeditepe University, Campus, Kayisdagi Cad, Kayisdagi, TR 34755 Istanbul, Turkey
    Curr Neurovasc Res 7:49-58. 2010
    ..In this report, we isolated human tooth germ stem cells (hTGSCs) with MSC characteristics from third molar tooth germs, cryo-preserved them at -80( degrees )..
  17. ncbi Alteration of the sialylation pattern of the murine tooth germ after ethanol exposure
    Dolores Jiménez-Farfán
    Laboratorio de Inmunologia, División de Estudios de Posgrado e Investigación, DEPeI, Facultad de Odontologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico
    Birth Defects Res A Clin Mol Teratol 73:980-8. 2005
    ..5 murine tooth germs exposed to ethanol...
  18. ncbi The eternal tooth germ is formed at the apical end of continuously growing teeth
    Hayato Ohshima
    Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Arch Oral Biol 50:153-7. 2005
    ..transverse sections of the apical end toward the incisal direction is likely to reflect the development of the tooth germ in the prenatal stage...
  19. ncbi In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar
    Merina Akhter
    Laboratory of Oral and Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Histol 41:185-91. 2010
    ..The expression of Ifrg15 mRNA was coincidently observed in various craniofacial organs as well as in the tooth germ. These results suggest that Ifrg15 is closely related to odontogenesis, especially the differentiation of the ..
  20. ncbi Effect of dental materials calcium hydroxide-containing cement, mineral trioxide aggregate, and enamel matrix derivative on proliferation and differentiation of human tooth germ stem cells
    Esra Pamukcu Guven
    Department of Endodontics, Yeditepe University, Istanbul, Turkey
    J Endod 37:650-6. 2011
    ..trioxide aggregate (MTA), and calcium hydroxide-containing cement (DYCAL) on proliferation and odontogenic differentiation of human tooth germ stem cells (hTGSCs) in which cells belonging to both pulp tissue and dental follicle exist.
  21. pmc Differentiation of mesenchymal stem cells from human umbilical cord tissue into odontoblast-like cells using the conditioned medium of tooth germ cells in vitro
    Tian xia Li
    Department of Prosthodontics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
    Biomed Res Int 2013:218543. 2013
    ..The third-passage hUCMSCs induced by conditioned medium from developing tooth germ cells (TGC-CM) displayed high alkaline phosphatase (ALP) levels (P < 0...
  22. ncbi In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar
    Jun ya Honda
    Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Histol 42:83-90. 2011
    ..5 to E18.0 to determine the precise expression patterns of Atpase6 mRNA in the developing tooth germ. Atpase6 mRNA was strongly expressed in the presumptive dental epithelium and the underlying mesenchyme at E10...
  23. ncbi Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar
    Merina Akhter
    Laboratory of Oral Pathology and Medicine, Kyushu University Graduate School of Dental Science, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Histochem Cell Biol 124:207-13. 2005
    ..We herein report for the first time that Tbeta4 is distinctly expressed in developing tooth germ, and it may also play functional roles in the initiation, growth and differentiation of tooth germ.
  24. ncbi Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture
    Kevin Tompkins
    Department of Cell and Molecular Biology, Northwestern University, Ward 13 100, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Connect Tissue Res 43:224-31. 2002
    ..Since the recombinant peptides are active, their corresponding tissue forms may be important in the stimulation of mesenchymal tissue differentiation. Thus, these specific amelogenin proteins may be involved in tooth morphogenesis...
  25. ncbi Characterization of dental epithelial progenitor cells derived from cervical-loop epithelium in a rat lower incisor
    S Kawano
    Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1 Manazuru, Kokurakita ku, Kitakyushu 803 8580, Japan
    J Dent Res 83:129-33. 2004
    ..These results suggest that fibroblast growth factor 10 plays a role in coupling mitogenesis of the cervical-loop cells and the production of stratum intermedium cells in rat incisors...
  26. ncbi Expression of prion gene and presence of prion protein during development of mouse molar tooth germ
    Qalb E Saleem Khan
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Eur J Oral Sci 118:559-65. 2010
    ..Expression of Prnp in the mouse first molar tooth germ was highly dynamic, increasing several-fold during the secretory phase of odontogenesis, exhibiting a time-..
  27. ncbi The relationship between the termination of cell proliferation and expression of heat-shock protein-25 in the rat developing tooth germ
    Naohiro Nakasone
    Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Oral Sci 114:302-9. 2006
    ..Numerous proliferating cells in developing molars were distributed throughout the tooth germ and HSP-25 immunoreactivity was recognizable in the dental epithelial and mesenchymal cells after they completed ..
  28. ncbi Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissues
    Z H Yang
    Department of Orthodontics, School of Stomatology, Fourth Millitary Medical University, 145 West Changle Road, Xi an, Shaanxi, China
    J Periodontal Res 44:199-210. 2009
    ..The aim of this study was to investigate the biological effect of conditioned medium from developing apical tooth germ cells (APTG-CM) on the differentiation and cementogenesis of PDLSCs both in vitro and in vivo.
  29. ncbi A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ
    Y Zhang
    Department of Cell and Molecular Biology, Molecular and Cell Biology Graduate Program, Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Development 127:1431-43. 2000
    ..Multiple signaling molecules are expressed in the developing tooth germ and interact each other to mediate the inductive tissue interactions...
  30. pmc Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse
    H Fong
    Department of Materials Science and Engineering, University of Washington, Seattle, WA, USA
    J Periodontol 80:1348-54. 2009
    ..Here, we report a developmental study of tooth root formation in Hyp mouse molars, focusing on dentin and cementum...
  31. ncbi Tooth agenesis: from molecular genetics to molecular dentistry
    E Matalova
    Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic
    J Dent Res 87:617-23. 2008
    ..In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed...
  32. ncbi Type II/III Runx2/Cbfa1 is required for tooth germ development
    Ieyoshi Kobayashi
    Laboratory of Oral Pathology and Medicine, Faculty of Oral Science, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Bone 38:836-44. 2006
    ..Runx2/Cbfa1 knockout mice showed both a complete lack of ossification and the developmental arrest of tooth germ. We here report Runx2/Cbfa1 isoform-type specific functional roles in the development of tooth germ by the ..
  33. ncbi Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning
    Paivi Kettunen
    Section of Anatomy and Cell Biology, Department of Biomedicine, Medical Faculty, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Mech Dev 124:868-83. 2007
    ..Tgfbeta1, which controls Sema3A was absent from the Fgfr2b(-/-) tooth germ, and Sema3A was specifically downregulated in the dental mesenchyme at the bud and cap stage...
  34. ncbi Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ
    Amer Sehic
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Physiol Genomics 43:488-98. 2011
    ..miR-214), encoded by the polycistronic Dnm30os gene, is highly expressed during development of molar tooth germ and was selected as a target for silencing with anti-miR-214...
  35. ncbi MicroRNA expression profiling of the developing murine molar tooth germ and the developing murine submandibular salivary gland
    Anne Marthe Jevnaker
    Department of Oral Biology, University of Oslo, Oslo, Norway
    Arch Oral Biol 53:629-45. 2008
    ..5, P0 and P5) of the murine first molar mandibular tooth germ and the right submandibular salivary gland (E15.5, P0, P5 and P25)...
  36. ncbi Expression, localisation and synthesis of versican by the enamel organ of developing mouse molar tooth germ: an in vivo and in vitro study
    Bei Zhan Jiang
    Division of Histology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 1757 Tobetsu cho, Ishikari gun, Hokkaido 061 0293, Japan
    Arch Oral Biol 55:995-1006. 2010
    ..In dental tissue, versican expression occurs primarily in mesenchymal tissue but rarely in epithelial tissue. We investigated the expression, localisation and synthesis of versican in the enamel organ of the developing tooth germ.
  37. ncbi Accelerated bone formation and increased osteoblast number contribute to the abnormal tooth germ development in parathyroid hormone-related protein knockout mice
    Y Kitahara
    Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Bone 35:1100-6. 2004
    ..In vivo and in vitro studies have shown that the development of the tooth germ proper is not disturbed, but insufficient alveolar bone resorption, due to the decreased number and hypofunction ..
  38. ncbi Fgf-2 regulates enamel and dentine formation in mouse tooth germ
    T Tsuboi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Japan
    Calcif Tissue Int 73:496-501. 2003
    We examined the effects of basic fibroblast growth factor (FGF-2) on cultured lower molar tooth germ at the differentiative (bell) stage...
  39. ncbi Collagen analysis in human tooth germ papillae
    Ivete Jorge Abrahão
    Department of Endodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil
    Braz Dent J 17:208-12. 2006
    ..In conclusion, the findings of this study showed that type III collagen is a regular component of the papillae of human tooth germs whereas type I collagen is present in a significantly lesser amount...
  40. ncbi Expression survey of genes critical for tooth development in the human embryonic tooth germ
    Dahe Lin
    College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, People s Republic of China
    Dev Dyn 236:1307-12. 2007
    ..Our results show that these genes exhibit basically similar expression patterns in the human tooth germ compared with that in the mouse...
  41. ncbi Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar
    J Y Honda
    Laboratory of Oral Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    Histol Histopathol 23:423-32. 2008
    ..expression patterns and possible functional roles of phosphoglycerate kinase 1 (Pgk1) gene in the developing tooth germ of the mouse lower first molar...
  42. ncbi The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
    Z Hardcastle
    Department of Craniofacial Development, UMDS, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Development 125:2803-11. 1998
    ..expressed in temporal and spatial patterns during early murine tooth development, suggestive of a role in early tooth germ initiation and subsequent epithelial-mesenchymal interactions...
  43. ncbi Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned medium
    Jinhua Yu
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng 12:3097-105. 2006
    ..In this study, we investigated the effect of conditioned medium from developing tooth germ cells (TGCs) on the differentiation and dentinogenesis of DPSCs both in vitro and in vivo...
  44. ncbi In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar
    Hiroko Wada
    Laboratory of Oral Pathology and Medicine, Faculty of Dental Science, Kyushu University 61, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Histochem J 34:105-9. 2002
    ..5, and then were slightly localized at E12 in an area where the tooth germ of the lower first molar is estimated to be formed...
  45. ncbi Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of mice
    Makoto J Tabata
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Suita, Japan
    Eur J Oral Sci 110:114-20. 2002
    ..5-d-old mice. In the tooth germ explants incubated for 14 d with antisense oligodeoxynucleotide (AS-ODN) against Bmp4 (a) cusps were not formed, ..
  46. ncbi Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ
    M T Cobourne
    Department of Craniofacial Development, GKT Dental Institute of Kings College London, Guy's Hospital, UK
    J Dent Res 80:1974-9. 2001
    ..Thus, Shh has dual roles in early odontogenesis, first in bud formation by stimulating epithelial proliferation, and second in the development of cap-stage tooth germs by increasing epithelial cell survival...
  47. ncbi In situ expression of ribosomal protein L21 in developing tooth germ of the mouse lower first molar
    Ming Xie
    Laboratory of Oral Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Histol 40:361-7. 2009
    ..in the synthesis of various polypeptides which might be related to the initiation and the development of such tooth germ, and also in the synthesis of enamel components in the presecretory stage of the ameloblast...
  48. ncbi Esthetic and endosurgical management of Turner's hypoplasia; a sequlae of trauma to developing tooth germ
    B A Bhushan
    Department of Pedodontics and Preventive Dentistry, M M College of Dental Sciences and Research, M M University Mullana, Ambala, Haryana, India
    J Indian Soc Pedod Prev Dent 26:S121-4. 2008
    ....
  49. ncbi Maturation ameloblasts of the porcine tooth germ do not express amelogenin
    K Wakida
    Department of Oral Anatomy, Hiroshima University School of Dentistry, Japan
    Histochem Cell Biol 111:297-303. 1999
    ....
  50. ncbi The effect of mechanical trauma on the tooth germ of rat molars at various developmental stages: a histopathological study
    K Taniguchi
    Department of Oral Pathology, Fukuoka Dental College, Japan
    Endod Dent Traumatol 15:17-25. 1999
    Intrusive trauma was experimentally applied to the tooth germ at different developmental stages in the rat first molar...
  51. ncbi Changes in gene-expression during development of the murine molar tooth germ
    Harald Osmundsen
    Department of Oral Biology, University of Oslo, Box 1052 Blindern, 0316 Oslo, Norway
    Arch Oral Biol 52:803-13. 2007
    In a matter of a few days the murine tooth germ develops into a complex, mineralized, structure. Murine 30K microarrays were used to examine gene expression in the mandibular first molar tooth germs isolated at 15.5dpc and at 2DPN...
  52. ncbi Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease
    Etsuko Ikeda
    Research Institute for Cell Engineering RICE, National Institute of Advanced Industrial Science and Technology AIST, 3 11 46 Nakoji, Amagasaki, Hyogo 661 0974, Japan
    Differentiation 76:495-505. 2008
    ..In the present study, we identified a novel stem cell, which we named tooth germ progenitor cells (TGPCs), from discarded third molar, commonly called as wisdom teeth...
  53. ncbi [Immunohistochemical localization of enamelin in developing rat tooth germ]
    Ping Lv
    Department of Cariology, Endodotology and Operative Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
    Beijing Da Xue Xue Bao 39:37-40. 2007
    ..To observe the immunohistochemical localization of enamelin in enamel formationand mineralization...
  54. ncbi Adequacy of mandibular premolar position despite early loss of its deciduous molar
    Atalia Wasserstein
    Department of Orthodontics, School of Dental Medicine, Tel Aviv University, Israel
    ASDC J Dent Child 69:254-8, 233-4. 2002
    ..Our findings do not show a significant influence of early loss of dM2 on the inclination of the unerupted MnP2, suggesting that environmental factors may be of less significance, compared with genetic ones...
  55. ncbi Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth
    Keijo Luukko
    Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, N 5009, Bergen, Norway
    Mech Dev 120:270-6. 2003
    ..Moreover, our results suggest that Slit1 signaling may be involved in the regulation of molar tooth shape by regulating epithelial cell proliferation and formation of EFA of the crown...
  56. ncbi Development of the dentition: four-dimensional visualization and open questions concerning the morphogenesis of tooth form and occlusion
    R J Radlanski
    Department of Experimental Dentistry, Benjamin Franklin University Clinic at Freie Universität Berlin, Berlin, Germany
    Orthod Craniofac Res 6:82-8. 2003
    ..Until today, it has not been clear how traffic of the ameloblasts is controlled, how the folding pattern of the occlusal relief is generated or how the enamel production is terminated at the enamel surface...
  57. ncbi Different distribution of immunocompetent cells in the dentogingival junction during root formation in rat molars
    Hiroshi Tamura
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho dori, Niigata, Japan
    J Periodontal Res 38:10-9. 2003
    ..dendritic or oval in shape, were abundantly distributed in the connective tissue between the oral epithelium and tooth germ. Positive cells with slender cell processes were also found beneath the ameloblast layer...
  58. ncbi [Effect of the Tabby mutation on the dentition of mice]
    H Lesot
    INSERM U595, Faculte de Medecine, Strasbourg, France
    Bull Group Int Rech Sci Stomatol Odontol 45:1-11. 2003
    ....
  59. ncbi Molecular insights into the lineage-specific determination of odontoblasts: the role of Cbfa1
    J S Gaikwad
    Department of Orthodontics, Dental Branch, Room 370, University of Texas Health Science Center at Houston, 6516 John Freeman Avenue, Houston, TX 77030, USA
    Adv Dent Res 15:19-24. 2001
    ....
  60. ncbi Relative levels of mRNA encoding enamel proteins in enamel organ epithelia and odontoblasts
    T Nagano
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Dent Res 82:982-6. 2003
    ..These results support the conclusion that odontoblasts are involved in the formation of the enamel layer adjacent to enamel-dentin junction...
  61. ncbi Expression of protein kinases C betaI, betaII, and VEGF during the differentiation of enamel epithelium in tooth development
    M Aida
    Department of Oral Pathology, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Dent Res 84:234-9. 2005
    ..These results indicate that PKC betaI, betaII, and VEGF are closely associated with the differentiation of the inner enamel epithelium to ameloblasts...
  62. ncbi Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice
    T Boran
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the CR, Prague, Czech Republic
    J Dent Res 84:228-33. 2005
    ..Analysis of the present data suggests that the increased apoptosis in Ta mice is a consequence of impaired tooth development caused by a defect in segmentation of dental epithelium...
  63. ncbi The expression pattern of hyaluronan synthase during human tooth development
    Sz Felszeghy
    Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Centre, Debrecen, Nagyerdei krt 98 H 4012, Hungary
    Arch Oral Biol 50:175-9. 2005
    ....
  64. ncbi Tissue-engineered hybrid tooth and bone
    Conan S Young
    Department of Cytokine Biology, Forsyth Institute, Boston, Massachusetts 02115, USA
    Tissue Eng 11:1599-610. 2005
    ..These results demonstrate the utility of a hybrid tooth-bone tissue-engineering approach for the eventual clinical treatment of tooth loss accompanied by alveolar bone resorption...
  65. ncbi Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth
    X P Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, University of Helsinki, Finland
    J Dent Res 84:138-43. 2005
    ..Similar buds were also present in Runx2 heterozygotes, and they may represent the extension of dental lamina for successional teeth. The results suggest that Runx2 prevents the formation of Shh-expressing buds for successional teeth...
  66. ncbi Characterization of human primary enamel organ epithelial cells in vitro
    P K DenBesten
    University of California at San Francisco, 94143 0640, USA
    Arch Oral Biol 50:689-94. 2005
    ..Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ...
  67. ncbi Shear stress facilitates tissue-engineered odontogenesis
    M J Honda
    Tooth Regeneration, The Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Bone 39:125-33. 2006
    ..Such was not the case in controls. We concluded that shear stress facilitates odontogenic cell differentiation in vitro as well as the process of tooth tissue engineering in vivo...
  68. ncbi Preliminary study of tissue-engineered odontogenesis in the canine jaw
    Masaki J Honda
    Tooth Regeneration, Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Oral Maxillofac Surg 64:283-9. 2006
    ..Therefore, the present study was designed to evaluate whether transplantation of dissociated odontogenic cells could induce tissue-engineered odontogenesis in the canine jaw...
  69. ncbi Molar tooth development in caspase-3 deficient mice
    Eva Matalova
    Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic
    Int J Dev Biol 50:491-7. 2006
    ..The results suggest that although caspase-3 becomes activated and may be essential for dental apoptosis, it does not seem fundamental for formation of normal mineralised molar teeth...
  70. ncbi Apoptosis distribution in the first molar tooth germ of the field vole (Microtus agrestis)
    E Matalova
    Laboratory of Genetics and Embryology IAPG CAS, Institute of Animal Physiology and Genetics, Academy of Sciences, Veveri 97, 602 00 Brno, Czech Republic
    Tissue Cell 36:361-7. 2004
    ..Apoptosis was shown to be involved in the first molar development of the field vole, however, exact mechanisms and roles of this process in tooth morphogenesis require further investigation...
  71. ncbi Identification of temporal and spatial expression patterns of amelogenin isoforms during mouse molar development
    Stanca Iacob
    Northwestern University, Feinberg School of Medicine, Department of Cell and Molecular Biology, Chicago, IL 60611, USA
    Eur J Oral Sci 114:194-200; discussion 201-2, 381. 2006
    ..In conclusion, ameloblasts, odontoblasts, and stratum intermedium cells demonstrate selective alternative splicing patterns of the amelogenin pre-mRNA transcript...
  72. ncbi Anisotropic properties of the enamel organic extracellular matrix
    Alexandre R do Espírito Santo
    Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    Eur J Oral Sci 114:333-7; discussion 349-50, 382. 2006
    ..The analysis of enamel organic matrix birefringence may be used to detect the effects of genetic and environmental factors on the supramolecular orientation of enamel matrix and their effects on the structure of mature enamel...
  73. ncbi Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage
    C Lillesaar
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Neuroscience 125:149-61. 2004
    ..We conclude that developing mandibular/dental mesenchyme can inhibit/repel neurite growth in vitro. Our results support the hypothesis that semaphorins may be involved in this interaction...
  74. ncbi Fluoride alters type I collagen expression in the early stages of odontogenesis
    I Maciejewska
    Department of Oral Implantology, Medical University, Gdansk, Poland
    Folia Morphol (Warsz) 65:359-66. 2006
    ..of our study was to determine the effects of fluoride on type I collagen expression during the early stages of tooth germ development in rats. Pregnant dams were divided into three groups and fed a standard diet...
  75. ncbi Influence of aging on tooth eruption: experimental canine mandibular allograft
    Emiko Tanaka
    First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry, Suita City, Japan
    J Oral Maxillofac Surg 62:353-60. 2004
    ..Aging is clinically related to tooth eruption; however, there are no known studies that have elucidated the relationship. We examined whether tooth eruption would occur normally in a mature subject...
  76. ncbi Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth
    Ibrahim O Bello
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    J Oral Pathol Med 36:48-54. 2007
    ..To analyze the distribution pattern of claudins 1, 4, 5, 7 and occludin in benign and malignant ameloblastomas and developing human teeth...
  77. ncbi [The expression and function of Smad7 during human tooth germ development]
    Liuyu Bao
    Department of Operative Dentistry and Endodontics, Stomatological College, Fourth Military Medical University, Xi an 710032, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:438-40. 2003
    To observe the temporal and spatial expression of Smad7 during human tooth germ development and evaluate the effect of Smad7 on tooth germ development.
  78. ncbi Histological and immunohistochemical studies of tissue engineered odontogenesis
    Masaki J Honda
    Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Arch Histol Cytol 68:89-101. 2005
    ..These aggregates assumed three different shapes: a natural tooth germ-like shape, a circular shape, or a bilayer-bundle...
  79. ncbi Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesis
    R L MacNeil
    Department of Periodontics Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    Connect Tissue Res 33:1-7. 1995
    ..These findings collectively suggest that BSP and OPN are intimately involved in the sequence of cellular and molecular events accompanying cementogenesis...
  80. ncbi Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo
    J Q Feng
    School of Dentistry, Dept of Oral Biology, University of Missouri Kansas City, 64108, USA
    J Dent Res 81:6-10. 2002
    ..The determination of unique domains by controlling the expression of the Bmp4 gene suggests that different transcriptional factors regulate the Bmp4 level at different stages during tooth morphogenesis...
  81. ncbi The secretion of amelogenins is associated with the induction of enamel and dentinoid in an ameloblastic fibro-odontoma
    H Yagishita
    Department of Pathology, Nippon Dental University, Tokyo, Japan
    J Oral Pathol Med 30:499-503. 2001
    ..The results obtained indicate that the odontogenic tumor epithelia and its products, i.e., amelogenins, participate in multifaceted aspects of dental hard tissue formation that takes place during oncogenesis...
  82. ncbi Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation
    S Løes
    Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, Bergen, Norway
    Mech Dev 107:155-7. 2001
    ..analysis showed that Slit1 mRNAs were expressed in the primary enamel knot of the bud and cap stage tooth germ and later the expression continued in the secondary enamel knots of the late cap and bell stage tooth...
  83. pmc Bioengineered dental tissues grown in the rat jaw
    S E Duailibi
    University Federal of São Paulo, Department of Plastic Surgery, Sao Paulo, Brazil
    J Dent Res 87:745-50. 2008
    ..The results presented in this report support the feasibility of bioengineered replacement tooth formation in the jaw...
  84. ncbi The spatial and temporal expression of calretinin in developing rat molars (Rattus norvegicus)
    D Mistry
    Department of Anatomical Pathology, Division of Oral Pathology, School of Oral Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa
    Arch Oral Biol 46:973-81. 2001
    ..In the secretory ameloblasts, the staining was less intense, being restricted to the cytoplasm, including Tomes' processes. This distribution suggests that calretinin may play a part in enamel formation...
  85. ncbi The effect of retinoic acid on mouse mandibular molar development in vitro, using alkaline phosphatase as a molecular indicator of differentiation
    D M Jones
    School of Anatomical Sciences, University of the Witwatersrand, Johannesburg
    SADJ 63:276, 278-80. 2008
    ..Retinoic acid is a known morphogen and is important in tooth development. In excess, retinoic acid has been found to alter the formation of teeth...
  86. ncbi Transformation of tooth type induced by inhibition of BMP signaling
    A S Tucker
    Department of Craniofacial Development, Guy s, King s, and St Thomas School of Dentistry, Guy s Hospital, London SE1 9RT, UK
    Science 282:1136-8. 1998
    ....
  87. ncbi Bone morphogenetic protein-7 (osteogenic protein-1, OP-1) and tooth development
    M N Helder
    Department of Oral Cell Biology, ACTA, Vrije Universiteit, Amsterdam, The Netherlands
    J Dent Res 77:545-54. 1998
    ....
  88. ncbi Spatiotemporal expression of the homeobox gene S8 during mouse tooth development
    H Karg
    Department of Oral Cell Biology, ACTA, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Oral Biol 42:625-31. 1997
    ..It is speculated that the time-restricted expression of S8 in tooth primordia involves establishing the definitive form of the tooth organ...
  89. ncbi Spatial and temporal distribution of sonic hedgehog mRNA in the embryonic mouse mandible by reverse transcription/polymerase chain reaction and in situ hybridization analysis
    J E Kronmiller
    Department of Orthodontics, School of Dentistry, Oregon Health Sciences University, Portland 97201, USA
    Arch Oral Biol 40:831-8. 1995
    ..Sonic hedgehog expression may be involved in the regulation of pattern formation through establishment of an incisor-molar axis of polarity...
  90. ncbi Amelogenin gene expression in porcine odontoblasts
    S Oida
    Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Dent Res 81:103-8. 2002
    ..In this study, we examined amelogenin gene expression in various cell layers prepared from a porcine permanent tooth germ using reverse transcription-polymerase chain-reaction (RT-PCR)...
  91. ncbi Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis
    Makoto Abe
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka 565 0871, Japan
    Cell Tissue Res 310:201-12. 2002
    ..of the presumptive incisor region of the lower jaw at an early stage and in the mesenchyme of the lower incisor tooth germ at a later stage...
  92. ncbi Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice
    P Kristenová
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:205-14. 2002
    ..The Ta syndome is homologous to the anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human and includes severe developmental defects of teeth, hair and sweat glands...
  93. ncbi Investigation of proliferative activity in the developing human tooth using Ki-67 immunostaining
    Gunseli Guven
    Department of Pediatric Dentistry, Center of Dental Sciences, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    Med Princ Pract 16:454-9. 2007
    The aim of this study was to investigate the proliferation of the developing human tooth germ and its surrounding tissues using Ki-67 immunostaining.
  94. ncbi Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium
    R Peterkova
    Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
    Orthod Craniofac Res 5:215-26. 2002
    ..The mouse Ta syndrome and its counterpart anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human are characterized by absence or hypoplasia of sweat glands, hair and teeth...
  95. ncbi Expression of connexin 43 and ZO-1 in differentiating ameloblasts and odontoblasts from rat molar tooth germs
    Sílvia M A João
    Laboratory of Mineralized Tissue Biology, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, S P, Brazil
    Histochem Cell Biol 119:21-6. 2003
    ..In addition, the expression of these junctional proteins increases as differentiation of cells continues...
  96. ncbi Expression and activity of matrix metalloproteinase-2 (MMP-2) in the development of rat first molar tooth germ
    Paola Cotrim
    Faculty of Dentistry of Piracicaba, UNICAMP, SP, Brazil
    Braz Dent J 13:97-102. 2002
    b>Tooth germ development is associated with morphological and biochemical changes of the dental papilla and enamel organ...
  97. ncbi Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers
    Sigbjørn Løes
    Department of Anatomy and Cell Biology, Arstadveien 19, University of Bergen, N 5009 Bergen, Norway
    Anat Embryol (Berl) 205:187-91. 2002
    ..emerging from the trigeminal maxillary and mandibular nerve trunks started to grow towards the developing molar tooth germ at the early bud stage, and subsequently they diverged into buccal and lingual branches next to the condensed ..
  98. ncbi Growing bioengineered teeth from single cells: potential for dental regenerative medicine
    Etsuko Ikeda
    Faculty of Industrial Science and Technology Tokyo University of Science, Department of Biological Science and Technology, Noda, Chiba 278 8510, Japan
    Expert Opin Biol Ther 8:735-44. 2008
    ..Dental regenerative medicine has made the most progress and is the most useful model for the consideration of strategies in future organ replacement therapies...
  99. ncbi Development of larval and transformed teeth in Ambystoma mexicanum (Urodela, Amphibia): an ultrastructural study
    J Wistuba
    Institut für Spezielle Zoologie und Vergleichende Embryologie der Universität Münster, Germany
    Tissue Cell 34:14-27. 2002
    ..This cavity appears to mediate amelogenesis. A small apical zone in early, but not in late larval teeth directly below the thin enamel layer consists of enameloid and is free of dentine channels...
  100. ncbi Asymmetrical morphogenesis and medio-lateral positioning of molars during mouse development
    Yves Cam
    INSERM Unit 424, Institut de Biologie Medicale, Faculté de Médecine de l Université Louis Pasteur, Strasbourg, France
    Eur J Oral Sci 110:35-43. 2002
    ....
  101. ncbi Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues
    Keijo Luukko
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Cell Tissue Res 319:143-52. 2005
    ..5-18.5). Ephrin-A1, ephrin-A5, EphA2, EphA3, EphA4, and EphA7 were expressed in the tooth germ at the epithelial thickening stage, and later, ephrin-A1, ephrin-A5, EphA2, EphA4, and EphA7 showed distinct ..

Research Grants25

  1. Tooth Root Formation: An Emerging Signaling Pathway
    Jian Q Feng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the advances made in identifying the signaling pathways in tooth germ and crown morphogenesis, the precise molecular events leading to root formation are largely unknown...
  2. Molecular Regulation of Early Odontogenesis
    Richard L Maas; Fiscal Year: 2013
    ..Lastly, in Aim 3, we will validate the new version 2.0 GRN both in vitro and in vivo. In vitro, we will perturb tooth germ explant cultures and primary dental mesenchymal cells in defined ways, and we will compare the gene expression ..
  3. Roles of Dmp1 in dentinogenesis
    Ling Ye; Fiscal Year: 2010
    ..through the duration of Award, such as gene targeting skill, electron microscopes skill, pulp cell culture, and tooth germ culture...
  4. SONIC HEDGEHOG SIGNALING IN ODONTOGENESIS
    Eiki Koyama; Fiscal Year: 2003
    ..molecules mediating epithelial-mesenchymal interactions, the modes of polarized growth, and the roles of "minor" tooth germ cell populations such as the inner dental epithelium-associated stratum intermedium...
  5. GENE REGULATION AND FUNCTION OF AMELOBLASTIN
    Paul Krebsbach; Fiscal Year: 2003
    ..Adenovirus-mediated infections will deliver ameloblastin promoter constructs to molar tooth germ organ cultures...
  6. GENE REGULATION AND FUNCTION OF AMELOBLASTIN
    Paul Krebsbach; Fiscal Year: 2002
    ..Adenovirus-mediated infections will deliver ameloblastin promoter constructs to molar tooth germ organ cultures...
  7. High Throughput Genome Sequencer for Organ Building
    Richard Maas; Fiscal Year: 2009
    ..construct gene regulatory networks (GRNs) that can be used by tissue engineers to build three organ parts, the tooth germ, the pancreatic islet, and the heart valve...
  8. De novo generation of mammalian tooth from stem cells
    YiPing Chen; Fiscal Year: 2006
    ..Lastly in Aim 3, we will test if in vitro assembled tooth germ is implantable and can develop into a functional tooth in the oral cavity by exo uteru surgery...
  9. A NEW STRATEGY TO ASSESS GENE FUNCTION IN TOOTH FORMATION
    YiPing Chen; Fiscal Year: 2006
    ..a methodology to generate a well-differentiated tooth organ from a single-cell suspension of embryonic mouse tooth germ. In this study we propose to use recombinant viral vectors that express siRNAs intracellularly to examine the ..
  10. POTENTIAL MSXL DOWNSTREAM GENES IN TOOTH DEVELOPMENT
    Marianna Bei; Fiscal Year: 2000
    The developing molar tooth germ provides a powerful developmental system for identifying the genetic pathways involved in mammalian organogenesis. Mutations in Msx1 are responsible for anodontia in both humans and mouse...
  11. Transgenic Zebrafish as Models for Tooth Morphogenesis
    William Jackman; Fiscal Year: 2005
    ..the movements of the dental epithelium, and the histone H2A:GFP line to follow the nuclei of each cell in the tooth germ. We also propose to generate new transgenic zebrafish lines expressing GFP and DsRed driven by Fgf4 regulatory ..
  12. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. CELL AND GENETIC APPROACHES TO ENAMEL BIOMIMETICS
    Malcolm Snead; Fiscal Year: 2007
    ..unreadable]..
  14. BUILDING THE TOOTH: BRIDGING BIOLOGY IN MATERIAL SCIENCES
    Malcolm Snead; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  15. GENE REGULATION OF RAT DENTIN SIALOPROTEIN
    HELENA RITCHIE; Fiscal Year: 2006
    ..These ongoing studies, which combine gene regulation and protein function approaches, will reveal underlying mechanisms of dentin mineralization and will later be applicable to reparative dentistry. ..
  16. ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2003
    ..Research into this relatively unexplored area will contribute to our understanding of the basic Msx1- Bmp4 signal pathway, mechanisms of tooth formation, and possible cause of autosomal dominant forms of familial tooth agenesis. ..
  17. ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2004
    ..Molecular techniques include RT-PCR, in situ hybridization, DNA sequence determination, SSCP (single strand conformational polymorphism), and heteroduplex analysis. ..
  18. AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTH
    JANET OLDAK; Fiscal Year: 2002
    ....
  19. STRUCTURE & ASSEMBLY OF COLLAGEN MOLECULES & FIBRILS
    Arthur Veis; Fiscal Year: 2004
    ..The final study (4) will examine N-telopeptide structures as related to molecular assembly into fibrils and the cross-link patterns that modulate packing. These studies will help in understanding dysfunction in humans. ..
  20. ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATION
    JANET OLDAK; Fiscal Year: 2008
    ..abstract_text> ..
  21. Biomechanical and Molecular Mechanisms in Alveolar Bone Development
    TRACY POPOWICS; Fiscal Year: 2008
    ..these experimental conditions. Taken together, these studies will provide fundamental new information about how tooth loading modifies alveolar bone in newly erupted teeth and promotes adaptive tooth support. ..
  22. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  23. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  24. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
    ..In this revision, more experimental details have been provided. ..