Genomes and Genes
Summary: The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)
Publications243 found, 100 shown here
- Tooth development: 1. Generating teeth in the embryoMaisa Seppala
Department of Orthodontics and Craniofacial Development, Floor 22 Guy s Hospital, GKT Dental Institute, King s College London, London SE1 9RT, UK
Dent Update 33:582-4, 586-8, 590-1. 2006....
- MicroRNAome and expression profile of developing tooth germ in miniature pigsAng Li
Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China
PLoS ONE 7:e52256. 2012....
- Early morphogenesis of heterodont dentition in minipigsJan Stembírek
Institute of Animal Physiology and Genetics, v v i, Academy of Sciences of the Czech Republic, Brno, Czech Republic
Eur J Oral Sci 118:547-58. 2010..After the primary tooth germ reached the late bell stage, the dental lamina began to disintegrate and fragmentize...
- Podoplanin expression in human tooth germ tissues and cystic odontogenic lesions: an immunohistochemical studyJozef Zustin
Institute of Pathology, University Medical Center Hamburg Eppendorf, Germany
J Oral Pathol Med 39:115-20. 2010Podoplanin expression was described in mouse tooth germ and apical bud cells. The aim of this study was to analyse the podoplanin expression of human tooth germ tissues, adult teeth and odontogenic lesions immunohistochemically.
- Generation of a bioengineered tooth by using a three-dimensional cell manipulation method (organ germ method)Masamitsu Oshima
Tokyo University of Science, Chiba, Japan
Methods Mol Biol 887:149-65. 2012..Here, we describe protocols for tooth germ reconstitution using the organ germ method and methods for analyzing tooth development in vitro and in vivo.
- Early regression of the dental lamina underlies the development of diphyodont dentitionsM Buchtová
Institute of Animal Physiology and Genetics, v v i, Academy of Sciences of the Czech Republic, Veveri 97, 602 00 Brno, Czech Republic
J Dent Res 91:491-8. 2012..The uncovering of the processes behind lamina degradation allows us to clarify the evolution of diphyodonty, and provides a mechanism for future manipulation of the number of tooth generations...
- Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesisP Kettunen
Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
Dev Dyn 211:256-68. 1998..The coexpression of Fgfs with other signaling molecules including Shh and several Bmps and their partly similar effects suggest that the FGFs participate in the signaling networks during odontogenesis...
- Bioengineered teeth from cultured rat tooth bud cellsM T Duailibi
University Federal of São Paulo, Department of Otorhinolaryngology and Human Communication Disorders, Sao Paolo, Brazil
J Dent Res 83:523-8. 2004..Furthermore, our ability to bioengineer tooth structures from cultured tooth bud cells suggests that dental epithelial and mesenchymal stem cells can be maintained in vitro for at least 6 days...
- Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesisM E Yalvac
Department of Genetics and Bioengineering, College of Engineering and Architecture, Yeditepe University, Kayisdagi, Istanbul, Turkey
Pharmacogenomics J 10:105-13. 2010..In this study, we isolated and characterized human tooth germ stem cells (hTGSCs) from third molars and assessed the expression of developmentally important transcription ..
- Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell-conditioned mediumNa Huo
Department of Orthodontics, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
Stem Cells Dev 19:93-104. 2010..By exposure to conditioned medium of embryonic and neonatal tooth germ cells in culture, the proliferation and mineralization activity of DMCs was elevated, while the embryonic tooth ..
- Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarrayK Heikinheimo
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
J Dent Res 81:525-30. 2002..The gene expression profile identifies candidate genes that may be involved in the origination of ameloblastoma and several genes previously unidentified in relation to human tooth development...
- GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblastsMichelle Tillmann Biz
Department of Cell and Developmental Biology, University of Sao Paulo, Sao Paulo, SP, Brazil
Cell Tissue Res 340:459-70. 2010..odontoblasts, Rac1 and its effector Pak3 were observed in ameloblasts; and Cdc42 was present in all cells of the tooth germ and mesenchyme...
- Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germY Zhang
Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
Dev Dyn 215:45-53. 1999We have used the mouse developing tooth germ as a model system to explore the transmission of Sonic hedgehog (Shh) signal in the induction of Patched (Ptc)...
- Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitroKevin Tompkins
Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Bone Miner Res 20:341-9. 2005..Our results show that these individual proteins have specific but quite different effects on epithelial-derived ameloblasts versus mesenchymal-derived odontoblasts...
- Extraction of "killer" teeth: the case of two Somali siblingsMarcio A da Fonseca
Section of Pediatric Dentistry, The Ohio State University, Nationwide Children s Hospital, Columbus, Ohio, USA
J Dent Child (Chic) 74:143-6. 2007..The purpose of this manuscript was to discuss the case of two Somali siblings who had tooth buds enucleated at a young age, leading to significant dental problems...
- Human tooth germ stem cells preserve neuro-protective effects after long-term cryo-preservationMehmet E Yalvac
Department of Genetics and Bioengineering, College of Engineering and Architecture, Yeditepe University, Campus, Kayisdagi Cad, Kayisdagi, TR 34755 Istanbul, Turkey
Curr Neurovasc Res 7:49-58. 2010..In this report, we isolated human tooth germ stem cells (hTGSCs) with MSC characteristics from third molar tooth germs, cryo-preserved them at -80( degrees )..
- Alteration of the sialylation pattern of the murine tooth germ after ethanol exposureDolores Jiménez-Farfán
Laboratorio de Inmunologia, División de Estudios de Posgrado e Investigación, DEPeI, Facultad de Odontologia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico
Birth Defects Res A Clin Mol Teratol 73:980-8. 2005..5 murine tooth germs exposed to ethanol...
- The eternal tooth germ is formed at the apical end of continuously growing teethHayato Ohshima
Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
Arch Oral Biol 50:153-7. 2005..transverse sections of the apical end toward the incisal direction is likely to reflect the development of the tooth germ in the prenatal stage...
- In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molarMerina Akhter
Laboratory of Oral and Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Mol Histol 41:185-91. 2010..The expression of Ifrg15 mRNA was coincidently observed in various craniofacial organs as well as in the tooth germ. These results suggest that Ifrg15 is closely related to odontogenesis, especially the differentiation of the ..
- Effect of dental materials calcium hydroxide-containing cement, mineral trioxide aggregate, and enamel matrix derivative on proliferation and differentiation of human tooth germ stem cellsEsra Pamukcu Guven
Department of Endodontics, Yeditepe University, Istanbul, Turkey
J Endod 37:650-6. 2011..trioxide aggregate (MTA), and calcium hydroxide-containing cement (DYCAL) on proliferation and odontogenic differentiation of human tooth germ stem cells (hTGSCs) in which cells belonging to both pulp tissue and dental follicle exist.
- Differentiation of mesenchymal stem cells from human umbilical cord tissue into odontoblast-like cells using the conditioned medium of tooth germ cells in vitroTian xia Li
Department of Prosthodontics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
Biomed Res Int 2013:218543. 2013..The third-passage hUCMSCs induced by conditioned medium from developing tooth germ cells (TGC-CM) displayed high alkaline phosphatase (ALP) levels (P < 0...
- In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molarJun ya Honda
Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Mol Histol 42:83-90. 2011..5 to E18.0 to determine the precise expression patterns of Atpase6 mRNA in the developing tooth germ. Atpase6 mRNA was strongly expressed in the presumptive dental epithelium and the underlying mesenchyme at E10...
- Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molarMerina Akhter
Laboratory of Oral Pathology and Medicine, Kyushu University Graduate School of Dental Science, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
Histochem Cell Biol 124:207-13. 2005..We herein report for the first time that Tbeta4 is distinctly expressed in developing tooth germ, and it may also play functional roles in the initiation, growth and differentiation of tooth germ.
- Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in cultureKevin Tompkins
Department of Cell and Molecular Biology, Northwestern University, Ward 13 100, 303 E Chicago Avenue, Chicago, IL 60611, USA
Connect Tissue Res 43:224-31. 2002..Since the recombinant peptides are active, their corresponding tissue forms may be important in the stimulation of mesenchymal tissue differentiation. Thus, these specific amelogenin proteins may be involved in tooth morphogenesis...
- Characterization of dental epithelial progenitor cells derived from cervical-loop epithelium in a rat lower incisorS Kawano
Department of Oral Anatomy and Cell Biology, Kyushu Dental College, 2 6 1 Manazuru, Kokurakita ku, Kitakyushu 803 8580, Japan
J Dent Res 83:129-33. 2004..These results suggest that fibroblast growth factor 10 plays a role in coupling mitogenesis of the cervical-loop cells and the production of stratum intermedium cells in rat incisors...
- Expression of prion gene and presence of prion protein during development of mouse molar tooth germQalb E Saleem Khan
Department of Oral Biology, University of Oslo, Oslo, Norway
Eur J Oral Sci 118:559-65. 2010..Expression of Prnp in the mouse first molar tooth germ was highly dynamic, increasing several-fold during the secretory phase of odontogenesis, exhibiting a time-..
- The relationship between the termination of cell proliferation and expression of heat-shock protein-25 in the rat developing tooth germNaohiro Nakasone
Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Eur J Oral Sci 114:302-9. 2006..Numerous proliferating cells in developing molars were distributed throughout the tooth germ and HSP-25 immunoreactivity was recognizable in the dental epithelial and mesenchymal cells after they completed ..
- Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissuesZ H Yang
Department of Orthodontics, School of Stomatology, Fourth Millitary Medical University, 145 West Changle Road, Xi an, Shaanxi, China
J Periodontal Res 44:199-210. 2009..The aim of this study was to investigate the biological effect of conditioned medium from developing apical tooth germ cells (APTG-CM) on the differentiation and cementogenesis of PDLSCs both in vitro and in vivo.
- A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germY Zhang
Department of Cell and Molecular Biology, Molecular and Cell Biology Graduate Program, Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
Development 127:1431-43. 2000..Multiple signaling molecules are expressed in the developing tooth germ and interact each other to mediate the inductive tissue interactions...
- Aberrant cementum phenotype associated with the hypophosphatemic hyp mouseH Fong
Department of Materials Science and Engineering, University of Washington, Seattle, WA, USA
J Periodontol 80:1348-54. 2009..Here, we report a developmental study of tooth root formation in Hyp mouse molars, focusing on dentin and cementum...
- Tooth agenesis: from molecular genetics to molecular dentistryE Matalova
Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic
J Dent Res 87:617-23. 2008..In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed...
- Type II/III Runx2/Cbfa1 is required for tooth germ developmentIeyoshi Kobayashi
Laboratory of Oral Pathology and Medicine, Faculty of Oral Science, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
Bone 38:836-44. 2006..Runx2/Cbfa1 knockout mice showed both a complete lack of ossification and the developmental arrest of tooth germ. We here report Runx2/Cbfa1 isoform-type specific functional roles in the development of tooth germ by the ..
- Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterningPaivi Kettunen
Section of Anatomy and Cell Biology, Department of Biomedicine, Medical Faculty, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Mech Dev 124:868-83. 2007..Tgfbeta1, which controls Sema3A was absent from the Fgfr2b(-/-) tooth germ, and Sema3A was specifically downregulated in the dental mesenchyme at the bud and cap stage...
- Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germAmer Sehic
Department of Oral Biology, University of Oslo, Oslo, Norway
Physiol Genomics 43:488-98. 2011..miR-214), encoded by the polycistronic Dnm30os gene, is highly expressed during development of molar tooth germ and was selected as a target for silencing with anti-miR-214...
- MicroRNA expression profiling of the developing murine molar tooth germ and the developing murine submandibular salivary glandAnne Marthe Jevnaker
Department of Oral Biology, University of Oslo, Oslo, Norway
Arch Oral Biol 53:629-45. 2008..5, P0 and P5) of the murine first molar mandibular tooth germ and the right submandibular salivary gland (E15.5, P0, P5 and P25)...
- Expression, localisation and synthesis of versican by the enamel organ of developing mouse molar tooth germ: an in vivo and in vitro studyBei Zhan Jiang
Division of Histology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Kanazawa 1757 Tobetsu cho, Ishikari gun, Hokkaido 061 0293, Japan
Arch Oral Biol 55:995-1006. 2010..In dental tissue, versican expression occurs primarily in mesenchymal tissue but rarely in epithelial tissue. We investigated the expression, localisation and synthesis of versican in the enamel organ of the developing tooth germ.
- Accelerated bone formation and increased osteoblast number contribute to the abnormal tooth germ development in parathyroid hormone-related protein knockout miceY Kitahara
Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
Bone 35:1100-6. 2004..In vivo and in vitro studies have shown that the development of the tooth germ proper is not disturbed, but insufficient alveolar bone resorption, due to the decreased number and hypofunction ..
- Fgf-2 regulates enamel and dentine formation in mouse tooth germT Tsuboi
Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Japan
Calcif Tissue Int 73:496-501. 2003We examined the effects of basic fibroblast growth factor (FGF-2) on cultured lower molar tooth germ at the differentiative (bell) stage...
- Collagen analysis in human tooth germ papillaeIvete Jorge Abrahão
Department of Endodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil
Braz Dent J 17:208-12. 2006..In conclusion, the findings of this study showed that type III collagen is a regular component of the papillae of human tooth germs whereas type I collagen is present in a significantly lesser amount...
- Expression survey of genes critical for tooth development in the human embryonic tooth germDahe Lin
College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, People s Republic of China
Dev Dyn 236:1307-12. 2007..Our results show that these genes exhibit basically similar expression patterns in the human tooth germ compared with that in the mouse...
- Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molarJ Y Honda
Laboratory of Oral Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Histol Histopathol 23:423-32. 2008..expression patterns and possible functional roles of phosphoglycerate kinase 1 (Pgk1) gene in the developing tooth germ of the mouse lower first molar...
- The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutantsZ Hardcastle
Department of Craniofacial Development, UMDS, Guy s Hospital, London Bridge, London SE1 9RT, UK
Development 125:2803-11. 1998..expressed in temporal and spatial patterns during early murine tooth development, suggestive of a role in early tooth germ initiation and subsequent epithelial-mesenchymal interactions...
- Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned mediumJinhua Yu
Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China
Tissue Eng 12:3097-105. 2006..In this study, we investigated the effect of conditioned medium from developing tooth germ cells (TGCs) on the differentiation and dentinogenesis of DPSCs both in vitro and in vivo...
- In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molarHiroko Wada
Laboratory of Oral Pathology and Medicine, Faculty of Dental Science, Kyushu University 61, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Histochem J 34:105-9. 2002..5, and then were slightly localized at E12 in an area where the tooth germ of the lower first molar is estimated to be formed...
- Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of miceMakoto J Tabata
Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Suita, Japan
Eur J Oral Sci 110:114-20. 2002..5-d-old mice. In the tooth germ explants incubated for 14 d with antisense oligodeoxynucleotide (AS-ODN) against Bmp4 (a) cusps were not formed, ..
- Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germM T Cobourne
Department of Craniofacial Development, GKT Dental Institute of Kings College London, Guy's Hospital, UK
J Dent Res 80:1974-9. 2001..Thus, Shh has dual roles in early odontogenesis, first in bud formation by stimulating epithelial proliferation, and second in the development of cap-stage tooth germs by increasing epithelial cell survival...
- In situ expression of ribosomal protein L21 in developing tooth germ of the mouse lower first molarMing Xie
Laboratory of Oral Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Mol Histol 40:361-7. 2009..in the synthesis of various polypeptides which might be related to the initiation and the development of such tooth germ, and also in the synthesis of enamel components in the presecretory stage of the ameloblast...
- Esthetic and endosurgical management of Turner's hypoplasia; a sequlae of trauma to developing tooth germB A Bhushan
Department of Pedodontics and Preventive Dentistry, M M College of Dental Sciences and Research, M M University Mullana, Ambala, Haryana, India
J Indian Soc Pedod Prev Dent 26:S121-4. 2008....
- Maturation ameloblasts of the porcine tooth germ do not express amelogeninK Wakida
Department of Oral Anatomy, Hiroshima University School of Dentistry, Japan
Histochem Cell Biol 111:297-303. 1999....
- The effect of mechanical trauma on the tooth germ of rat molars at various developmental stages: a histopathological studyK Taniguchi
Department of Oral Pathology, Fukuoka Dental College, Japan
Endod Dent Traumatol 15:17-25. 1999Intrusive trauma was experimentally applied to the tooth germ at different developmental stages in the rat first molar...
- Changes in gene-expression during development of the murine molar tooth germHarald Osmundsen
Department of Oral Biology, University of Oslo, Box 1052 Blindern, 0316 Oslo, Norway
Arch Oral Biol 52:803-13. 2007In a matter of a few days the murine tooth germ develops into a complex, mineralized, structure. Murine 30K microarrays were used to examine gene expression in the mandibular first molar tooth germs isolated at 15.5dpc and at 2DPN...
- Multipotent cells from the human third molar: feasibility of cell-based therapy for liver diseaseEtsuko Ikeda
Research Institute for Cell Engineering RICE, National Institute of Advanced Industrial Science and Technology AIST, 3 11 46 Nakoji, Amagasaki, Hyogo 661 0974, Japan
Differentiation 76:495-505. 2008..In the present study, we identified a novel stem cell, which we named tooth germ progenitor cells (TGPCs), from discarded third molar, commonly called as wisdom teeth...
- [Immunohistochemical localization of enamelin in developing rat tooth germ]Ping Lv
Department of Cariology, Endodotology and Operative Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
Beijing Da Xue Xue Bao 39:37-40. 2007..To observe the immunohistochemical localization of enamelin in enamel formationand mineralization...
- Adequacy of mandibular premolar position despite early loss of its deciduous molarAtalia Wasserstein
Department of Orthodontics, School of Dental Medicine, Tel Aviv University, Israel
ASDC J Dent Child 69:254-8, 233-4. 2002..Our findings do not show a significant influence of early loss of dM2 on the inclination of the unerupted MnP2, suggesting that environmental factors may be of less significance, compared with genetic ones...
- Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar toothKeijo Luukko
Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, N 5009, Bergen, Norway
Mech Dev 120:270-6. 2003..Moreover, our results suggest that Slit1 signaling may be involved in the regulation of molar tooth shape by regulating epithelial cell proliferation and formation of EFA of the crown...
- Development of the dentition: four-dimensional visualization and open questions concerning the morphogenesis of tooth form and occlusionR J Radlanski
Department of Experimental Dentistry, Benjamin Franklin University Clinic at Freie Universität Berlin, Berlin, Germany
Orthod Craniofac Res 6:82-8. 2003..Until today, it has not been clear how traffic of the ameloblasts is controlled, how the folding pattern of the occlusal relief is generated or how the enamel production is terminated at the enamel surface...
- Different distribution of immunocompetent cells in the dentogingival junction during root formation in rat molarsHiroshi Tamura
Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho dori, Niigata, Japan
J Periodontal Res 38:10-9. 2003..dendritic or oval in shape, were abundantly distributed in the connective tissue between the oral epithelium and tooth germ. Positive cells with slender cell processes were also found beneath the ameloblast layer...
- [Effect of the Tabby mutation on the dentition of mice]H Lesot
INSERM U595, Faculte de Medecine, Strasbourg, France
Bull Group Int Rech Sci Stomatol Odontol 45:1-11. 2003....
- Molecular insights into the lineage-specific determination of odontoblasts: the role of Cbfa1J S Gaikwad
Department of Orthodontics, Dental Branch, Room 370, University of Texas Health Science Center at Houston, 6516 John Freeman Avenue, Houston, TX 77030, USA
Adv Dent Res 15:19-24. 2001....
- Relative levels of mRNA encoding enamel proteins in enamel organ epithelia and odontoblastsT Nagano
Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
J Dent Res 82:982-6. 2003..These results support the conclusion that odontoblasts are involved in the formation of the enamel layer adjacent to enamel-dentin junction...
- Expression of protein kinases C betaI, betaII, and VEGF during the differentiation of enamel epithelium in tooth developmentM Aida
Department of Oral Pathology, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
J Dent Res 84:234-9. 2005..These results indicate that PKC betaI, betaII, and VEGF are closely associated with the differentiation of the inner enamel epithelium to ameloblasts...
- Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA miceT Boran
Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the CR, Prague, Czech Republic
J Dent Res 84:228-33. 2005..Analysis of the present data suggests that the increased apoptosis in Ta mice is a consequence of impaired tooth development caused by a defect in segmentation of dental epithelium...
- The expression pattern of hyaluronan synthase during human tooth developmentSz Felszeghy
Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Centre, Debrecen, Nagyerdei krt 98 H 4012, Hungary
Arch Oral Biol 50:175-9. 2005....
- Tissue-engineered hybrid tooth and boneConan S Young
Department of Cytokine Biology, Forsyth Institute, Boston, Massachusetts 02115, USA
Tissue Eng 11:1599-610. 2005..These results demonstrate the utility of a hybrid tooth-bone tissue-engineering approach for the eventual clinical treatment of tooth loss accompanied by alveolar bone resorption...
- Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teethX P Wang
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, FIN 00014, University of Helsinki, Finland
J Dent Res 84:138-43. 2005..Similar buds were also present in Runx2 heterozygotes, and they may represent the extension of dental lamina for successional teeth. The results suggest that Runx2 prevents the formation of Shh-expressing buds for successional teeth...
- Characterization of human primary enamel organ epithelial cells in vitroP K DenBesten
University of California at San Francisco, 94143 0640, USA
Arch Oral Biol 50:689-94. 2005..Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ...
- Shear stress facilitates tissue-engineered odontogenesisM J Honda
Tooth Regeneration, The Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Bone 39:125-33. 2006..Such was not the case in controls. We concluded that shear stress facilitates odontogenic cell differentiation in vitro as well as the process of tooth tissue engineering in vivo...
- Preliminary study of tissue-engineered odontogenesis in the canine jawMasaki J Honda
Tooth Regeneration, Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
J Oral Maxillofac Surg 64:283-9. 2006..Therefore, the present study was designed to evaluate whether transplantation of dissociated odontogenic cells could induce tissue-engineered odontogenesis in the canine jaw...
- Molar tooth development in caspase-3 deficient miceEva Matalova
Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic
Int J Dev Biol 50:491-7. 2006..The results suggest that although caspase-3 becomes activated and may be essential for dental apoptosis, it does not seem fundamental for formation of normal mineralised molar teeth...
- Apoptosis distribution in the first molar tooth germ of the field vole (Microtus agrestis)E Matalova
Laboratory of Genetics and Embryology IAPG CAS, Institute of Animal Physiology and Genetics, Academy of Sciences, Veveri 97, 602 00 Brno, Czech Republic
Tissue Cell 36:361-7. 2004..Apoptosis was shown to be involved in the first molar development of the field vole, however, exact mechanisms and roles of this process in tooth morphogenesis require further investigation...
- Identification of temporal and spatial expression patterns of amelogenin isoforms during mouse molar developmentStanca Iacob
Northwestern University, Feinberg School of Medicine, Department of Cell and Molecular Biology, Chicago, IL 60611, USA
Eur J Oral Sci 114:194-200; discussion 201-2, 381. 2006..In conclusion, ameloblasts, odontoblasts, and stratum intermedium cells demonstrate selective alternative splicing patterns of the amelogenin pre-mRNA transcript...
- Anisotropic properties of the enamel organic extracellular matrixAlexandre R do Espírito Santo
Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil
Eur J Oral Sci 114:333-7; discussion 349-50, 382. 2006..The analysis of enamel organic matrix birefringence may be used to detect the effects of genetic and environmental factors on the supramolecular orientation of enamel matrix and their effects on the structure of mature enamel...
- Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stageC Lillesaar
Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
Neuroscience 125:149-61. 2004..We conclude that developing mandibular/dental mesenchyme can inhibit/repel neurite growth in vitro. Our results support the hypothesis that semaphorins may be involved in this interaction...
- Fluoride alters type I collagen expression in the early stages of odontogenesisI Maciejewska
Department of Oral Implantology, Medical University, Gdansk, Poland
Folia Morphol (Warsz) 65:359-66. 2006..of our study was to determine the effects of fluoride on type I collagen expression during the early stages of tooth germ development in rats. Pregnant dams were divided into three groups and fed a standard diet...
- Influence of aging on tooth eruption: experimental canine mandibular allograftEmiko Tanaka
First Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry, Suita City, Japan
J Oral Maxillofac Surg 62:353-60. 2004..Aging is clinically related to tooth eruption; however, there are no known studies that have elucidated the relationship. We examined whether tooth eruption would occur normally in a mature subject...
- Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teethIbrahim O Bello
Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
J Oral Pathol Med 36:48-54. 2007..To analyze the distribution pattern of claudins 1, 4, 5, 7 and occludin in benign and malignant ameloblastomas and developing human teeth...
- [The expression and function of Smad7 during human tooth germ development]Liuyu Bao
Department of Operative Dentistry and Endodontics, Stomatological College, Fourth Military Medical University, Xi an 710032, China
Hua Xi Kou Qiang Yi Xue Za Zhi 21:438-40. 2003To observe the temporal and spatial expression of Smad7 during human tooth germ development and evaluate the effect of Smad7 on tooth germ development.
- Histological and immunohistochemical studies of tissue engineered odontogenesisMasaki J Honda
Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Arch Histol Cytol 68:89-101. 2005..These aggregates assumed three different shapes: a natural tooth germ-like shape, a circular shape, or a bilayer-bundle...
- Role of two mineral-associated adhesion molecules, osteopontin and bone sialoprotein, during cementogenesisR L MacNeil
Department of Periodontics Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
Connect Tissue Res 33:1-7. 1995..These findings collectively suggest that BSP and OPN are intimately involved in the sequence of cellular and molecular events accompanying cementogenesis...
- Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivoJ Q Feng
School of Dentistry, Dept of Oral Biology, University of Missouri Kansas City, 64108, USA
J Dent Res 81:6-10. 2002..The determination of unique domains by controlling the expression of the Bmp4 gene suggests that different transcriptional factors regulate the Bmp4 level at different stages during tooth morphogenesis...
- The secretion of amelogenins is associated with the induction of enamel and dentinoid in an ameloblastic fibro-odontomaH Yagishita
Department of Pathology, Nippon Dental University, Tokyo, Japan
J Oral Pathol Med 30:499-503. 2001..The results obtained indicate that the odontogenic tumor epithelia and its products, i.e., amelogenins, participate in multifaceted aspects of dental hard tissue formation that takes place during oncogenesis...
- Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formationS Løes
Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, Bergen, Norway
Mech Dev 107:155-7. 2001..analysis showed that Slit1 mRNAs were expressed in the primary enamel knot of the bud and cap stage tooth germ and later the expression continued in the secondary enamel knots of the late cap and bell stage tooth...
- Bioengineered dental tissues grown in the rat jawS E Duailibi
University Federal of São Paulo, Department of Plastic Surgery, Sao Paulo, Brazil
J Dent Res 87:745-50. 2008..The results presented in this report support the feasibility of bioengineered replacement tooth formation in the jaw...
- The spatial and temporal expression of calretinin in developing rat molars (Rattus norvegicus)D Mistry
Department of Anatomical Pathology, Division of Oral Pathology, School of Oral Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa
Arch Oral Biol 46:973-81. 2001..In the secretory ameloblasts, the staining was less intense, being restricted to the cytoplasm, including Tomes' processes. This distribution suggests that calretinin may play a part in enamel formation...
- The effect of retinoic acid on mouse mandibular molar development in vitro, using alkaline phosphatase as a molecular indicator of differentiationD M Jones
School of Anatomical Sciences, University of the Witwatersrand, Johannesburg
SADJ 63:276, 278-80. 2008..Retinoic acid is a known morphogen and is important in tooth development. In excess, retinoic acid has been found to alter the formation of teeth...
- Transformation of tooth type induced by inhibition of BMP signalingA S Tucker
Department of Craniofacial Development, Guy s, King s, and St Thomas School of Dentistry, Guy s Hospital, London SE1 9RT, UK
Science 282:1136-8. 1998....
- Bone morphogenetic protein-7 (osteogenic protein-1, OP-1) and tooth developmentM N Helder
Department of Oral Cell Biology, ACTA, Vrije Universiteit, Amsterdam, The Netherlands
J Dent Res 77:545-54. 1998....
- Spatiotemporal expression of the homeobox gene S8 during mouse tooth developmentH Karg
Department of Oral Cell Biology, ACTA, Vrije Universiteit, Amsterdam, The Netherlands
Arch Oral Biol 42:625-31. 1997..It is speculated that the time-restricted expression of S8 in tooth primordia involves establishing the definitive form of the tooth organ...
- Spatial and temporal distribution of sonic hedgehog mRNA in the embryonic mouse mandible by reverse transcription/polymerase chain reaction and in situ hybridization analysisJ E Kronmiller
Department of Orthodontics, School of Dentistry, Oregon Health Sciences University, Portland 97201, USA
Arch Oral Biol 40:831-8. 1995..Sonic hedgehog expression may be involved in the regulation of pattern formation through establishment of an incisor-molar axis of polarity...
- Amelogenin gene expression in porcine odontoblastsS Oida
Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
J Dent Res 81:103-8. 2002..In this study, we examined amelogenin gene expression in various cell layers prepared from a porcine permanent tooth germ using reverse transcription-polymerase chain-reaction (RT-PCR)...
- Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesisMakoto Abe
Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka 565 0871, Japan
Cell Tissue Res 310:201-12. 2002..of the presumptive incisor region of the lower jaw at an early stage and in the mesenchyme of the lower incisor tooth germ at a later stage...
- Different morphotypes of functional dentition in the lower molar region of tabby (EDA) miceP Kristenová
Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
Orthod Craniofac Res 5:205-14. 2002..The Ta syndome is homologous to the anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human and includes severe developmental defects of teeth, hair and sweat glands...
- Investigation of proliferative activity in the developing human tooth using Ki-67 immunostainingGunseli Guven
Department of Pediatric Dentistry, Center of Dental Sciences, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
Med Princ Pract 16:454-9. 2007The aim of this study was to investigate the proliferation of the developing human tooth germ and its surrounding tissues using Ki-67 immunostaining.
- Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epitheliumR Peterkova
Institute of Experimental Medicine, Academy of Sciences CR, Prague, Czech Republic
Orthod Craniofac Res 5:215-26. 2002..The mouse Ta syndrome and its counterpart anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human are characterized by absence or hypoplasia of sweat glands, hair and teeth...
- Expression of connexin 43 and ZO-1 in differentiating ameloblasts and odontoblasts from rat molar tooth germsSílvia M A João
Laboratory of Mineralized Tissue Biology, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, S P, Brazil
Histochem Cell Biol 119:21-6. 2003..In addition, the expression of these junctional proteins increases as differentiation of cells continues...
- Expression and activity of matrix metalloproteinase-2 (MMP-2) in the development of rat first molar tooth germPaola Cotrim
Faculty of Dentistry of Piracicaba, UNICAMP, SP, Brazil
Braz Dent J 13:97-102. 2002b>Tooth germ development is associated with morphological and biochemical changes of the dental papilla and enamel organ...
- Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibersSigbjørn Løes
Department of Anatomy and Cell Biology, Arstadveien 19, University of Bergen, N 5009 Bergen, Norway
Anat Embryol (Berl) 205:187-91. 2002..emerging from the trigeminal maxillary and mandibular nerve trunks started to grow towards the developing molar tooth germ at the early bud stage, and subsequently they diverged into buccal and lingual branches next to the condensed ..
- Growing bioengineered teeth from single cells: potential for dental regenerative medicineEtsuko Ikeda
Faculty of Industrial Science and Technology Tokyo University of Science, Department of Biological Science and Technology, Noda, Chiba 278 8510, Japan
Expert Opin Biol Ther 8:735-44. 2008..Dental regenerative medicine has made the most progress and is the most useful model for the consideration of strategies in future organ replacement therapies...
- Development of larval and transformed teeth in Ambystoma mexicanum (Urodela, Amphibia): an ultrastructural studyJ Wistuba
Institut für Spezielle Zoologie und Vergleichende Embryologie der Universität Münster, Germany
Tissue Cell 34:14-27. 2002..This cavity appears to mediate amelogenesis. A small apical zone in early, but not in late larval teeth directly below the thin enamel layer consists of enameloid and is free of dentine channels...
- Asymmetrical morphogenesis and medio-lateral positioning of molars during mouse developmentYves Cam
INSERM Unit 424, Institut de Biologie Medicale, Faculté de Médecine de l Université Louis Pasteur, Strasbourg, France
Eur J Oral Sci 110:35-43. 2002....
- Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissuesKeijo Luukko
Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
Cell Tissue Res 319:143-52. 2005..5-18.5). Ephrin-A1, ephrin-A5, EphA2, EphA3, EphA4, and EphA7 were expressed in the tooth germ at the epithelial thickening stage, and later, ephrin-A1, ephrin-A5, EphA2, EphA4, and EphA7 showed distinct ..
- Tooth Root Formation: An Emerging Signaling PathwayJian Q Feng; Fiscal Year: 2013DESCRIPTION (provided by applicant): Despite the advances made in identifying the signaling pathways in tooth germ and crown morphogenesis, the precise molecular events leading to root formation are largely unknown...
- Molecular Regulation of Early OdontogenesisRichard L Maas; Fiscal Year: 2013..Lastly, in Aim 3, we will validate the new version 2.0 GRN both in vitro and in vivo. In vitro, we will perturb tooth germ explant cultures and primary dental mesenchymal cells in defined ways, and we will compare the gene expression ..
- Roles of Dmp1 in dentinogenesisLing Ye; Fiscal Year: 2010..through the duration of Award, such as gene targeting skill, electron microscopes skill, pulp cell culture, and tooth germ culture...
- SONIC HEDGEHOG SIGNALING IN ODONTOGENESISEiki Koyama; Fiscal Year: 2003..molecules mediating epithelial-mesenchymal interactions, the modes of polarized growth, and the roles of "minor" tooth germ cell populations such as the inner dental epithelium-associated stratum intermedium...
- GENE REGULATION AND FUNCTION OF AMELOBLASTINPaul Krebsbach; Fiscal Year: 2003..Adenovirus-mediated infections will deliver ameloblastin promoter constructs to molar tooth germ organ cultures...
- GENE REGULATION AND FUNCTION OF AMELOBLASTINPaul Krebsbach; Fiscal Year: 2002..Adenovirus-mediated infections will deliver ameloblastin promoter constructs to molar tooth germ organ cultures...
- High Throughput Genome Sequencer for Organ BuildingRichard Maas; Fiscal Year: 2009..construct gene regulatory networks (GRNs) that can be used by tissue engineers to build three organ parts, the tooth germ, the pancreatic islet, and the heart valve...
- De novo generation of mammalian tooth from stem cellsYiPing Chen; Fiscal Year: 2006..Lastly in Aim 3, we will test if in vitro assembled tooth germ is implantable and can develop into a functional tooth in the oral cavity by exo uteru surgery...
- A NEW STRATEGY TO ASSESS GENE FUNCTION IN TOOTH FORMATIONYiPing Chen; Fiscal Year: 2006..a methodology to generate a well-differentiated tooth organ from a single-cell suspension of embryonic mouse tooth germ. In this study we propose to use recombinant viral vectors that express siRNAs intracellularly to examine the ..
- POTENTIAL MSXL DOWNSTREAM GENES IN TOOTH DEVELOPMENTMarianna Bei; Fiscal Year: 2000The developing molar tooth germ provides a powerful developmental system for identifying the genetic pathways involved in mammalian organogenesis. Mutations in Msx1 are responsible for anodontia in both humans and mouse...
- Transgenic Zebrafish as Models for Tooth MorphogenesisWilliam Jackman; Fiscal Year: 2005..the movements of the dental epithelium, and the histone H2A:GFP line to follow the nuclei of each cell in the tooth germ. We also propose to generate new transgenic zebrafish lines expressing GFP and DsRed driven by Fgf4 regulatory ..
- A Critical Role of DMP-1 in MineralizationJian Feng; Fiscal Year: 2007..unreadable] [unreadable]..
- CELL AND GENETIC APPROACHES TO ENAMEL BIOMIMETICSMalcolm Snead; Fiscal Year: 2007..unreadable]..
- BUILDING THE TOOTH: BRIDGING BIOLOGY IN MATERIAL SCIENCESMalcolm Snead; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- GENE REGULATION OF RAT DENTIN SIALOPROTEINHELENA RITCHIE; Fiscal Year: 2006..These ongoing studies, which combine gene regulation and protein function approaches, will reveal underlying mechanisms of dentin mineralization and will later be applicable to reparative dentistry. ..
- ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENTJian Feng; Fiscal Year: 2003..Research into this relatively unexplored area will contribute to our understanding of the basic Msx1- Bmp4 signal pathway, mechanisms of tooth formation, and possible cause of autosomal dominant forms of familial tooth agenesis. ..
- ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENTJian Feng; Fiscal Year: 2004..Molecular techniques include RT-PCR, in situ hybridization, DNA sequence determination, SSCP (single strand conformational polymorphism), and heteroduplex analysis. ..
- AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTHJANET OLDAK; Fiscal Year: 2002....
- STRUCTURE & ASSEMBLY OF COLLAGEN MOLECULES & FIBRILSArthur Veis; Fiscal Year: 2004..The final study (4) will examine N-telopeptide structures as related to molecular assembly into fibrils and the cross-link patterns that modulate packing. These studies will help in understanding dysfunction in humans. ..
- ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATIONJANET OLDAK; Fiscal Year: 2008..abstract_text> ..
- Biomechanical and Molecular Mechanisms in Alveolar Bone DevelopmentTRACY POPOWICS; Fiscal Year: 2008..these experimental conditions. Taken together, these studies will provide fundamental new information about how tooth loading modifies alveolar bone in newly erupted teeth and promotes adaptive tooth support. ..
- Eda/Edar Regulation of Embryonic SMG DevelopmentTina Jaskoll; Fiscal Year: 2007....
- A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATIONJANET OLDAK; Fiscal Year: 2004..abstract_text> ..
- Signaling activities of amelogenin gene splice products.Arthur Veis; Fiscal Year: 2006..In this revision, more experimental details have been provided. ..