dentin

Summary

Summary: The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)

Top Publications

  1. ncbi Physicochemical basis of the biologic properties of mineral trioxide aggregate
    N K Sarkar
    Operative Dentistry and Biomaterials Department, LSU, School of Dentistry, 1100 Florida Ave, New Orleans, LA 70119, USA
    J Endod 31:97-100. 2005
  2. ncbi Induction of specific cell responses to a Ca(3)SiO(5)-based posterior restorative material
    Patrick Laurent
    Laboratoire IMEB ERT 30, Faculté d Odontologie, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13355 Marseille Cedex 05, France
    Dent Mater 24:1486-94. 2008
  3. ncbi The use of dentin matrix scaffold and dental follicle cells for dentin regeneration
    Weihua Guo
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an 710032, China
    Biomaterials 30:6708-23. 2009
  4. ncbi An in vitro comparison of the intraradicular dentin bond strength of Resilon and gutta-percha
    Lance J Skidmore
    Department of Endodontics, Marquette University, School of Dentistry, Milwaukee, Wisconsin 53233, USA
    J Endod 32:963-6. 2006
  5. ncbi Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Norway
    J Endod 28:634-7. 2002
  6. ncbi Dentin hypersensitivity and its management
    C H Chu
    University of Hong Kong
    Gen Dent 59:115-22; quiz 123-4. 2011
  7. ncbi Topographical, diametral, and quantitative analysis of dentin tubules in the root canals of human and bovine teeth
    Carlos H R Camargo
    Sao Jose dos Campos, Faculty of Dentistry, Sao Paulo State University UNESP, Av Fco José Longo 777, 12245 000 São Paulo, SP, Brazil
    J Endod 33:422-6. 2007
  8. ncbi Does a low-shrinking composite induce less stress at the adhesive interface?
    Annelies Van Ende
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    Dent Mater 26:215-22. 2010
  9. pmc In vitro reparative dentin: a biochemical and morphological study
    G Teti
    University of Bologna
    Eur J Histochem 57:e23. 2013
  10. ncbi Influence of irrigation regimens on the adherence of Enterococcus faecalis to root canal dentin
    Anil Kishen
    Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, Singapore
    J Endod 34:850-4. 2008

Detail Information

Publications396 found, 100 shown here

  1. ncbi Physicochemical basis of the biologic properties of mineral trioxide aggregate
    N K Sarkar
    Operative Dentistry and Biomaterials Department, LSU, School of Dentistry, 1100 Florida Ave, New Orleans, LA 70119, USA
    J Endod 31:97-100. 2005
    ..aggregate with a synthetic tissue fluid composed of a neutral phosphate buffer saline solution and root canal dentin in extracted human teeth using inductively coupled plasma-atomic emission spectroscopy, scanning electron ..
  2. ncbi Induction of specific cell responses to a Ca(3)SiO(5)-based posterior restorative material
    Patrick Laurent
    Laboratoire IMEB ERT 30, Faculté d Odontologie, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13355 Marseille Cedex 05, France
    Dent Mater 24:1486-94. 2008
    ..A Ca(3)SiO(5)-based cement has been developed to circumvent the shortcomings of traditional filling materials. The purpose of this work was to evaluate its genotoxicity, cytotoxicity and effects on the target cells' specific functions...
  3. ncbi The use of dentin matrix scaffold and dental follicle cells for dentin regeneration
    Weihua Guo
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an 710032, China
    Biomaterials 30:6708-23. 2009
    Scaffold and inductive microenvironment are the two most important factors for dentin regeneration...
  4. ncbi An in vitro comparison of the intraradicular dentin bond strength of Resilon and gutta-percha
    Lance J Skidmore
    Department of Endodontics, Marquette University, School of Dentistry, Milwaukee, Wisconsin 53233, USA
    J Endod 32:963-6. 2006
    ..0 mm thick disks (n = 15 per group). Micropush-out bond strengths to root canal dentin were measured...
  5. ncbi Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells
    Isabelle Portenier
    Department of Endodontics, Dental Faculty, University of Oslo, Norway
    J Endod 28:634-7. 2002
    ..chlorhexidine digluconate and iodine potassium iodide on Enterococcus faecalis A197A was tested in the presence of dentin, dentin matrix, dentin pretreated by EDTA and citric acid, collagen, and heat-killed cells of Enterococcus ..
  6. ncbi Dentin hypersensitivity and its management
    C H Chu
    University of Hong Kong
    Gen Dent 59:115-22; quiz 123-4. 2011
    b>Dentin hypersensitivity is a common patient complaint that is more prevalent than the profession realizes...
  7. ncbi Topographical, diametral, and quantitative analysis of dentin tubules in the root canals of human and bovine teeth
    Carlos H R Camargo
    Sao Jose dos Campos, Faculty of Dentistry, Sao Paulo State University UNESP, Av Fco José Longo 777, 12245 000 São Paulo, SP, Brazil
    J Endod 33:422-6. 2007
    The aim of this study was to evaluate the number and the diameter of dentin tubules in root canals, in the cervical, middle, and apical thirds, of human and bovine teeth...
  8. ncbi Does a low-shrinking composite induce less stress at the adhesive interface?
    Annelies Van Ende
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    Dent Mater 26:215-22. 2010
    ..Therefore, we investigated the effect of C-factor (flat surface vs. class-I cavity) and different composite application protocols on the bonding effectiveness of a low-shrinking composite to human dentin.
  9. pmc In vitro reparative dentin: a biochemical and morphological study
    G Teti
    University of Bologna
    Eur J Histochem 57:e23. 2013
    ..Biochemical assays demonstrated that the differentiated phenotype expressed odontoblast markers, such as Dentin Matrix Protein 1 (DMP1) and Dentin Sialoprotein (DSP), as well as type I collagen...
  10. ncbi Influence of irrigation regimens on the adherence of Enterococcus faecalis to root canal dentin
    Anil Kishen
    Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, Singapore
    J Endod 34:850-4. 2008
    ..is the earliest stage in biofilm formation, eliciting the factors that links adherence of this bacterium to dentin would help in understanding its association with treatment-failed root canals...
  11. pmc Tooth dentin defects reflect genetic disorders affecting bone mineralization
    S Opsahl Vital
    Dental School University Paris Descartes PRES Sorbonne Paris Cité, EA 2496, Montrouge, F 92120, France
    Bone 50:989-97. 2012
    Several genetic disorders affecting bone mineralization may manifest during dentin mineralization...
  12. ncbi Residual and antimicrobial activity of final irrigation protocols on Enterococcus faecalis biofilm in dentin
    Pilar Baca
    Department of Preventive and Operative Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 37:363-6. 2011
    ..solutions exerting antimicrobial activity and prolonged residual activity is desirable in order to control dentin infection and delay reinfection of the root canal...
  13. ncbi Effect of different concentrations of fluoride in dentifrices on dentin erosion subjected or not to abrasion in situ/ex vivo
    A C Magalhaes
    Department of Pediatric and Social Dentistry, School of Dentistry of Aracatuba, Sao Paulo State University, Aracatuba, Brazil
    Caries Res 42:112-6. 2008
    This in situ/ex vivo study assessed the effect of different concentrations of fluoride in dentifrices on dentin subjected to erosion or to erosion plus abrasion...
  14. ncbi The effect of calcium hydroxide root filling on dentin fracture strength
    Brett Rosenberg
    Department of Endodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328 2018, USA
    Dent Traumatol 23:26-9. 2007
    ..9 Mpa per 77 days: an average of 0.157 MPa day-1. Between 7 and 84 days, the MTFS of the dentin was reduced by 43.9%. This difference was statistically significant (P < 0.05)...
  15. ncbi The dentin-enamel junction and the fracture of human teeth
    V Imbeni
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, California 94720, USA
    Nat Mater 4:229-32. 2005
    The dentin-enamel junction (DEJ), which is the interfacial region between the dentin and outer enamel coating in teeth, is known for its unique biomechanical properties that provide a crack-arrest barrier for flaws formed in the brittle ..
  16. ncbi Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief
    Diane Cummins
    Colgate Palmolive Technology Center, Piscataway, NJ, USA
    J Clin Dent 20:1-9. 2009
    ..provides an overview of the current knowledge of diagnosis, epidemiology, etiology, and clinical management of dentin hypersensitivity...
  17. ncbi Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2
    K Iohara
    Department of Clinical Oral Molecular Biology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Higashiku, Fukuoka, Japan
    J Dent Res 83:590-5. 2004
    ..Dental pulp tissue has the potential to regenerate dentin in response to noxious stimuli, such as caries. The progenitor/stem cells are responsible for this regeneration...
  18. ncbi Interfacial strength of Resilon and gutta-percha to intraradicular dentin
    Andrea Gesi
    Department of Restorative Dentistry and Dental Materials, University of Siena, Italy
    J Endod 31:809-13. 2005
    ..by improvement in the interfacial strength and dislocation resistance between the root fillings and intraradicular dentin. This study compared the interfacial strengths of Resilon/Epiphany and gutta-percha/AH Plus using a thin-slice ..
  19. pmc Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin
    Sunita P Ho
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, UCSF, 707 Parnassus Avenue, San Francisco, CA 94143 0758, USA
    Acta Biomater 5:707-18. 2009
    This work seeks to establish comparisons of the physical properties of rat and human cementum, root dentin and their interface, including the cementum-dentin junction (CDJ), as a basis for future studies of the entire periodontal complex ..
  20. ncbi Dentin alteration of deciduous teeth in human hypophosphatemic rickets
    T Boukpessi
    Laboratoire Réparation et Remodelage des Tissus Oro Faciaux, EA 2496 Groupe Matrices Extracellulaires et Biominéralisations, Faculte de Chirurgie Dentaire, Université University Paris 5, 1 rue Maurice Arnoux, 92120 Montrouge, France
    Calcif Tissue Int 79:294-300. 2006
    ..Patients have been reported to display important dentin defects, and therefore, we explored the dentin structure, composition, and distribution of extracellular matrix (..
  21. pmc Survival of atraumatic restorative treatment (ART) sealants and restorations: a meta-analysis
    Rodrigo G de Amorim
    Department of Dentistry, Faculty of Health Science, University of Brasilia, Brasilia, Federal District, Brazil
    Clin Oral Investig 16:429-41. 2012
    ..The short-term survival rates of single-surface ART restorations in primary and permanent teeth, and the caries-preventive effect of ART sealants were high...
  22. ncbi Effects of pH and acid concentration on erosive dissolution of enamel, dentine, and compressed hydroxyapatite
    R P Shellis
    Clinical Trials Group, School of Oral and Dental Sciences, University of Bristol, Bristol, UK
    Eur J Oral Sci 118:475-82. 2010
    ..The variation in response of the dissolution rate to acid concentration/buffer capacity with respect to pH and tissue type might complicate attempts to predict erosive potential from solution composition...
  23. pmc Experimental determination of the periodicity of incremental features in enamel
    T M Smith
    Department of Anthropology, Stony Brook University, Stony Brook, NY 11794, USA
    J Anat 208:99-113. 2006
    ..Studies of the genetic, neurological and hormonal basis of incremental feature formation are needed to provide more insight into their physiological and structural basis...
  24. ncbi Setting characteristics and cavity adaptation of low-shrinking resin composites
    Dimitris Papadogiannis
    Department of Biomaterials, School of Dentistry, University of Athens, Greece
    Dent Mater 25:1509-16. 2009
    The aim of this study was to evaluate the setting characteristics of low-shrinking resin composites and examine the possible interactions with curing efficiency and marginal adaptation in dentin cavities.
  25. ncbi The effects of sodium hypochlorite (5.25%), Chlorhexidine (2%), and Glyde File Prep on the bond strength of MTA-dentin
    Ping Yan
    Department of Endodontics, School of Stomatology, Wuhan University, Luoyu Road 237, Wuhan City, China 430079
    J Endod 32:58-60. 2006
    ..25%), chlorhexidine (2%), and Glyde File Prep on the bond strengths of MTA-dentin in vitro...
  26. pmc Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model
    George T J Huang
    Section of Oral and Diagnostic Sciences, Division of Endodontics, College of Dental Medicine, Columbia University, New York, New York, USA
    Tissue Eng Part A 16:605-15. 2010
    The ultimate goal of this study is to regenerate lost dental pulp and dentin via stem/progenitor cell-based approaches and tissue engineering technologies...
  27. ncbi The effectiveness of different acid irrigating solutions in root canal cleaning after hand and rotary instrumentation
    Mercedes Pérez-Heredia
    Department of Dental Pathology and Therapeutics, School of Dentistry, University of Granada Spain, Campus de Cartuja, Granada, Spain
    J Endod 32:993-7. 2006
    ..However, 2.5% NaOCl did not remove smear layer or debris, and no significant differences in debris were observed between manual and rotary techniques...
  28. pmc Substantivity of chlorhexidine to human dentin
    Marcela R Carrilho
    GEO UNIBAN, Health Institute, Bandeirante University of Sao Paulo, Sao Paulo, Brazil
    Dent Mater 26:779-85. 2010
    To better comprehend the role of CHX in the preservation of resin-dentin bonds, this study investigated the substantivity of CHX to human dentin.
  29. ncbi Influence of thermal stress on marginal integrity of restorative materials
    Maximiliano Sergio Cenci
    Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Appl Oral Sci 16:106-10. 2008
    ..Cervical and incisal walls were located in dentin and enamel, respectively...
  30. ncbi Antimicrobial substantivity over time of chlorhexidine and cetrimide
    Pilar Baca
    Department of Preventive Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Endod 38:927-30. 2012
    To reach an adequate control of dentin infection and to promote success in endodontic therapy, antimicrobial irrigating solutions with confirmed substantivity are recommended...
  31. ncbi Effect of acidic environment on the push-out bond strength of mineral trioxide aggregate
    Noushin Shokouhinejad
    Department of Endodontics, Faculty of Dentistry Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Endod 36:871-4. 2010
    ..In this study, the effect of an acidic environment on the push-out strength of MTA was evaluated...
  32. pmc Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth - a prospective study
    Gilles Koubi
    Service d Odontologie Gaston Berger, CHU de Marseille, 17 19 boulevard Mireille Lauze, 13010, Marseille, France
    Clin Oral Investig 17:243-9. 2013
    ..A multicentric randomized, 3-year prospective study was conducted to determine for how long Biodentine, a new biocompatible dentine substitute, can remain as a posterior restoration...
  33. ncbi Nanoleakage, ultramorphological characteristics, and microtensile bond strengths of a new low-shrinkage composite to dentin after artificial aging
    Sillas Duarte
    Department of Comprehensive Care, Case Western Reserve University, School of Dental Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    Dent Mater 25:589-600. 2009
    To study the microtensile bond strengths and nanoleakage of low-shrinkage composite to dentin. The null hypotheses tested were (1) aging does not affect the bonding of low-shrinkage composite; (2) there is no difference in microtensile ..
  34. ncbi Characterization of dentin, enamel, and carious lesions by a polarization-sensitive optical coherence tomography system
    Yueli Chen
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 1157, USA
    Appl Opt 44:2041-8. 2005
    Enamel and dentin are the primary components of human teeth. Both of them have a strong polarization effect...
  35. ncbi Dentinal tubule infection as the cause of recurrent disease and late endodontic treatment failure: a case report
    Adalberto R Vieira
    Brazilian Association of Dentistry, Juiz de Fora, Minas Gerais, Brazil
    J Endod 38:250-4. 2012
    ..This article describes a case of recurrent post-treatment apical periodontitis and late failure after endodontic retreatment performed in a single visit...
  36. ncbi Randomized trial on fluorides and sealants for fissure caries prevention
    B Y Liu
    Faculty of Dentistry, University of Hong Kong, 3 F, Prince Philip Dental Hospital, Hong Kong SAR
    J Dent Res 91:753-8. 2012
    ..After 24 months, 485 children (97%) were examined. Proportions of pit/fissure sites with dentin caries in the sealant, NaF, SDF, and control groups were 1.6%, 2.4%, 2.2%, and 4.6%, respectively...
  37. ncbi Microbiological analysis after complete or partial removal of carious dentin in primary teeth: a randomized clinical trial
    E C O Lula
    Graduate Program in Health Sciences, College of Dentistry, Federal University of Maranhao, Sao Luis, Brazil
    Caries Res 43:354-8. 2009
    ..clinical trial was to examine the microflora of primary teeth treated by complete or partial removal of carious dentin. Deciduous molars with acute carious lesions in the inner half of dentin and vital pulp were randomly divided into ..
  38. ncbi Hereditary dentin defects
    J W Kim
    Seoul National University, School of Dentistry Department of Pediatric Dentistry and Dental Research Institute, 28 2 Yongon Dong, Chongno Gu, Seoul, Korea 110 749
    J Dent Res 86:392-9. 2007
    By the Shields classification, articulated over 30 years ago, inherited dentin defects are divided into 5 types: 3 types of dentinogenesis imperfecta (DGI), and 2 types of dentin dysplasia (DD)...
  39. ncbi The impact of root dentine conditioning on sealing ability and push-out bond strength of an epoxy resin root canal sealer
    P Neelakantan
    Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India
    Int Endod J 44:491-8. 2011
    ..To investigate the impact of dentine conditioning on sealing ability and dentine bond strength of an epoxy resin sealer...
  40. ncbi The expression of dentin sialophosphoprotein gene in bone
    C Qin
    Department of Basic Sciences, The University of Texas Houston Health Science Center Dental Branch, 6516 M D Anderson Boulevard, DBB Rm 4 133, Houston, TX 77030, USA
    J Dent Res 81:392-4. 2002
    b>Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) are expressed as a single mRNA transcript coding for a large precursor protein termed dentin sialophosphoprotein (DSPP)...
  41. ncbi Evaluation of three different scoring systems for dental erosion: a comparative study in adolescents
    Vasileios Margaritis
    Department of Preventive and Community Dentistry, Dental School, National and Kapodistrian University of Athens, 2, Thivon Street, 11527 Goudi, Athens, Greece
    J Dent 39:88-93. 2011
    ..W.I.), and the Evaluating Index of Dental Erosion (EV.I.D.E.), which are introduced and calibrated in the present study, in order to contribute to the development of a standardised and validated erosion index...
  42. ncbi The mechanical properties of human dentin: a critical review and re-evaluation of the dental literature
    J H Kinney
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, Mail Stop 0758, University of California, San Francisco, San Francisco, CA 94143 0758, USA
    Crit Rev Oral Biol Med 14:13-29. 2003
    The past 50 years of research on the mechanical properties of human dentin are reviewed...
  43. ncbi Effects of different exposure times and concentrations of sodium hypochlorite/ethylenediaminetetraacetic acid on the structural integrity of mineralized dentin
    Kai Zhang
    Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, China
    J Endod 36:105-9. 2010
    ..3% NaOCl/17% ethylenediaminetetraacetic acid (EDTA) and 5.25% NaOCl/17% EDTA irrigation regimens on the collagen degradation and flexural strength reduction in mineralized dentin.
  44. ncbi Dentin-derived BMP-2 and odontoblast differentiation
    L Casagrande
    Department of Pediatric Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    J Dent Res 89:603-8. 2010
    ..However, the nature of dentin-derived morphogenic signals required for dental pulp stem cell differentiation remains unclear...
  45. ncbi Effects of irrigation solutions on dentin wettability and roughness
    Xiaoli Hu
    Department of Operative Dentistry and Endodontics, Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, China
    J Endod 36:1064-7. 2010
    ..It is hypothesized that irrigation solutions might influence the physicochemical properties of human root canal dentin including the wettability and roughness.
  46. ncbi Comparison of the efficacy of maleic acid and ethylenediaminetetraacetic acid in smear layer removal from instrumented human root canal: a scanning electron microscopic study
    Nidambur Vasudev Ballal
    Manipal College of Dental Sciences, Karnataka, India
    J Endod 35:1573-6. 2009
    ..The aim of this study was to assess, by scanning electron microscopic (SEM) analysis, the ability of 17% EDTA and 7% maleic acid in the removal of the smear layer from the human root canal system...
  47. ncbi Effect of calcium removal on dentin bond strengths
    J Perdigao
    Division of Operative Dentistry, Department of Restorative Sciences, University of Minnesota, Minneapolis, Minnesota, USA
    Quintessence Int 32:142-6. 2001
    ..in vitro study was to determine the microtensile bond strengths (mu TBS) of 3 dental adhesives when applied to dentin decalcified with ethylenediaminetetraacetic acid (EDTA)...
  48. ncbi Survival of Enterococcus faecalis in root canals ex vivo
    C M Sedgley
    Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Int Endod J 38:735-42. 2005
    ..faecalis in instrumented root canals and (iii) gelatinase-production capacity influences the survival of E. faecalis in root canals...
  49. ncbi Decalcifying effect of 15% EDTA, 15% citric acid, 5% phosphoric acid and 2.5% sodium hypochlorite on root canal dentine
    M Pérez-Heredia
    Department of Dental Pathology and Therapeutics, School of Dentistry, University of Granada, Spain
    Int Endod J 41:418-23. 2008
    ..To evaluate and compare ex vivo the decalcifying effect of 15% EDTA, 15% citric acid, 5% phosphoric acid and 2.5% sodium hypochlorite on root canal dentine...
  50. ncbi Ultrastructural examination of dentin using focused ion-beam cross-sectioning and transmission electron microscopy
    R K Nalla
    Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA
    Micron 36:672-80. 2005
    ..In this study, we seek to evaluate the FIB as a TEM preparation tool for human dentin. Two particular problems involving dentin, a structural analog of bone that makes up the bulk of the human tooth, ..
  51. ncbi Adhesion to tooth structure: a critical review of "macro" test methods
    Roberto R Braga
    University of Sao Paulo School of Dentistry, Dept of Dental Materials, Av Prof Lineu Prestes, 2227, Sao Paulo, SP 05508 000, Brazil
    Dent Mater 26:e38-49. 2010
    ..This review focuses on aspects related to specimen geometry and test mechanics of "macro" shear and tensile bond strength tests...
  52. ncbi Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms
    Chun Hung Chu
    The University of Hong Kong, China
    Int J Paediatr Dent 22:2-10. 2012
    ..mutans or A. naeslundii formed on dentine surfaces. SDF slowed down demineralization of dentine. This dual activity could be the reason behind clinical success of SDF...
  53. ncbi NovaMin and dentin hypersensitivity--in vitro evidence of efficacy
    Anora Burwell
    NovaMin Technology Inc, Alachua, FL, USA
    J Clin Dent 21:66-71. 2010
    The objective of this study was to determine the ability of a calcium sodium phosphosilicate (NovaMin) particulate to occlude dentin tubules, and to characterize the nature of the occlusion through a number of in vitro studies.
  54. ncbi Effect of collagenase and esterase on resin-dentin interface: a comparative study between a total-etch adhesive and a self-etch adhesive
    Young Jung Jung
    Department of Dentistry, School of Medicine, Ewha Womans University, Seoul, South Korea
    Am J Dent 22:295-8. 2009
    ..the effects of collagenase and esterase activity on the microtensile bond strength and nanoleakage at the resin-dentin interfaces of two adhesive systems: a total-etch adhesive (Single Bond 2: SB) and a self-etch adhesive (Clearfil ..
  55. ncbi Caries-preventive effect of resin-based and glass ionomer sealants over time: a systematic review
    N Beiruti
    Regional WHO Demonstration, Training and Research Centre for Oral Health, Mezah, Damascus, Syria
    Community Dent Oral Epidemiol 34:403-9. 2006
    ..Two recently published reviews were unable to conclude on the difference because the comparison was an exclusion criterion in one review and there were statistical shortcomings in the relevant papers in the other (Cochrane) review...
  56. pmc Limitations in bonding to dentin and experimental strategies to prevent bond degradation
    Y Liu
    Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan 430030, People s Republic of China
    J Dent Res 90:953-68. 2011
    The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations...
  57. ncbi Recent advances in the theory and mechanism of adhesive resin bonding to dentin: a critical review
    T K Vaidyanathan
    Department of Restorative Dentistry, NJ Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biomed Mater Res B Appl Biomater 88:558-78. 2009
    b>Dentin bonding issues involving adhesive resins have attracted considerable research interest in recent years. An important advance due to the ongoing research is the concept of hybridization of the tissue with primer/adhesive systems...
  58. ncbi Influence of moisture conditions on dentin bond strength of single-step self-etch adhesive systems
    Yasushi Chiba
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    J Oral Sci 48:131-7. 2006
    This study was conducted to clarify the influence of dentin surface moisture on bond strength of single-step self-etch adhesive systems...
  59. pmc Functional biomimetic analogs help remineralize apatite-depleted demineralized resin-infiltrated dentin via a bottom-up approach
    Jongryul Kim
    Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seou, South Korea
    Acta Biomater 6:2740-50. 2010
    ..Using an acid-etched human dentin model to create a layer of completely demineralized collagen matrix, a bio-inspired mineralization scheme has been ..
  60. pmc State of the art etch-and-rinse adhesives
    David H Pashley
    Department of Oral Biology, Medical College of Georgia, School of Dentistry, Augusta, GA, USA
    Dent Mater 27:1-16. 2011
    ..The aim of this study was to explore the therapeutic opportunities of each step of 3-step etch-and-rinse adhesives...
  61. ncbi Effects of endodontic post surface treatment, dentin conditioning, and artificial aging on the retention of glass fiber-reinforced composite resin posts
    Zakereyya S Albashaireh
    Jordan University of Science and Technology, Irbid 22110, Jordan
    J Prosthet Dent 103:31-9. 2010
    ..A regimen that produces the maximum bond strength of glass fiber-reinforced composite resin posts has not been verified...
  62. ncbi Bond strength of composite to astringent-contaminated dentin using self-etching adhesives
    Kathy L O'Keefe
    Department of Restorative Dentistry and Biomaterials, The University of Texas Dental Branch at Houston, 6516 M D Anderson Blvd, Houston, Texas 77030, USA
    Am J Dent 18:168-72. 2005
    To determine the effects of contamination by ferric sulfate and aluminum chloride astringents on the bond strength of composite bonded to superficial dentin using self-etching adhesives.
  63. ncbi Substantive antimicrobial activity in chlorhexidine-treated human root dentin
    Bettina Basrani
    Department of Endodontics, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:240-5. 2002
    The aim of this in vitro study was to assess the substantive antimicrobial activity of different medicaments in human root dentin.
  64. ncbi Effect of desensitizing agents on the hydraulic conductance of human dentin subjected to different surface pre-treatments--an in vitro study
    Jose C Pereira
    Department of Restorative Dentistry, Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    Dent Mater 21:129-38. 2005
    The aim of this study was to evaluate the variation of fluid filtration across dentin treated with different formulations of potassium oxalate gels and one gel of acidified sodium fluorophosphate, under five different pre-conditioned ..
  65. ncbi Effect of chelating solutions on the microhardness of root canal lumen dentin
    Antonio M Cruz-Filho
    Department of Endodontics, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Endod 37:358-62. 2011
    The greatest reduction in microhardness of the most superficial layer of dentin of the root canal lumen is desired...
  66. ncbi Chlorhexidine gluconate in endodontics: an update review
    Zahed Mohamadi Kanisavaran
    Int Dent J 58:247-57. 2008
    ..Furthermore, because of its cationic structure, chlorhexidine has a unique property named substantivity. The purpose of this paper is to review different aspects of the use of chlorhexidine gluconate in endodontics...
  67. ncbi Chelating agents in root canal treatment: mode of action and indications for their use
    M Hulsmann
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Gottingen, Germany
    Int Endod J 36:810-30. 2003
    ..This paper reviews the relevant literature on chelating agents, presents an overview of the chemical and pharmacological properties of EDTA preparations and makes recommendations for their clinical use...
  68. ncbi Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004
    The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development. In vitro study suggests that this noncollagen acidic phosphoprotein plays a role in mineralization...
  69. ncbi Differences in bonding to acid-etched or Er:YAG-laser-treated enamel and dentin surfaces
    A Martinez-Insua
    Santiago de Compostela University, Santiago de Compostela, Spain
    J Prosthet Dent 84:280-8. 2000
    ..It has been suggested that they are also useful for preparing dental surfaces for adhesion, but results to date have been controversial...
  70. ncbi A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth
    Irene Petrou
    Colgate Palmolive Technology Center, Piscataway, NJ, USA
    J Clin Dent 20:23-31. 2009
    ..range of state-of-the-art surface techniques to gain insight into the mechanism of action of a new technology for dentin hypersensitivity relief based upon arginine and calcium carbonate and, in particular, to address important ..
  71. ncbi An ultra-morphological characterization of collagen-depleted etched dentin
    J Perdigao
    Dept of Operative Dentistry CB 7450, University of North Carolina at Chapel Hill 27599 7450, USA
    Am J Dent 12:250-5. 1999
    To evaluate the ultramorphology of superficial and deep dentin after etching with 35% phosphoric acid (H3PO4) and after etching with 35% H3PO4 followed by deproteinization with 5% sodium hypochlorite (NaOCl).
  72. ncbi Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentine by etch-and-rinse adhesives
    Annalisa Mazzoni
    Department of SAU and FAL, University of Bologna, Bologna, Italy
    Biomaterials 27:4470-6. 2006
    ..This provides an explanation for the degradation of hybrid layers after acid-etched dentine matrices are infiltrated with these adhesives...
  73. ncbi Influence of NaOCl deproteinization on shear bond strength in function of dentin depth
    Manuel Toledano
    Department of Dental Materials, School of Dentistry, University of Granada, Spain
    Am J Dent 15:252-5. 2002
    To determine the influence of NaOCl application on shear bond strengths (SBS) to superficial and deep dentin, using Prime & Bond 2.1.
  74. ncbi Elimination of Candida albicans infection of the radicular dentin by intracanal medications
    Jose F Siqueira
    Department of Endodontics, Estacio de Sa University, Rio de Janeiro, RJ, Brazil
    J Endod 29:501-4. 2003
    ..purpose of this study was to evaluate the effectiveness of four intracanal medications in disinfecting the root dentin of bovine teeth experimentally infected with Candida albicans...
  75. ncbi Caries-preventive effect of a one-time application of composite resin and glass ionomer sealants after 5 years
    N Beiruti
    Regional WHO Demonstration, Training and Research Centre for Oral Health, Damascus, Syria
    Caries Res 40:52-9. 2006
    ..A well-designed clinical trial using different types of oral health personnel should be implemented to confirm these initial results...
  76. ncbi Dentin enhances the antibacterial effect of mineral trioxide aggregate and bioaggregate
    Hui Zhang
    Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    J Endod 35:221-4. 2009
    ..The antimicrobial effect of the cements mixed with equal amounts of human dentin powder was also tested...
  77. ncbi Effects of chelating agents and sodium hypochlorite on mineral content of root dentin
    H Dogan
    Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    J Endod 27:578-80. 2001
    Effects of combined and single use of EDTA, RC-Prep, and NaOCl on mineral content of root dentin were evaluated in vitro using energy dispersion spectrometric microanalysis...
  78. ncbi Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts
    S Toyosawa
    Department of Oral Pathology, Osaka University Graduate School of Dentistry, Suita, Japan
    J Bone Miner Res 16:2017-26. 2001
    ..b>Dentin matrix protein 1 (DMP1) is an acidic phosphoprotein expressed in tooth organ and bone...
  79. ncbi Push-out bond strengths of the dentine-sealer interface with and without a main cone
    A Jainaen
    School of Dental Science, The University of Melbourne, Melbourne, Victoria, Australia
    Int Endod J 40:882-90. 2007
    ..To evaluate the push-out bond strength of the dentine-sealer interface with and without main cone for three resin sealers...
  80. ncbi Effects of dentin on the antimicrobial properties of endodontic medicaments
    Markus Haapasalo
    Division of Endodontics, Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    J Endod 33:917-25. 2007
    ..Recent studies have given valuable information about the interaction of endodontic disinfecting agents with dentin and other compounds present in the necrotic root canal...
  81. ncbi Fungi in endodontic infections
    Jose F Siqueira
    Department of Endontics, School of Dentistry, Estacio de Sa University, Rio de Janiero, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:632-41. 2004
    ..canals, and this species has been considered a dentinophilic microorganism because of its invasive affinity to dentin. C albicans has also been discovered to be resistant to some intracanal medicaments, such as calcium hydroxide...
  82. ncbi Influence of thermal cycling on dentin bond strengths of single-step self-etch adhesive systems
    Youhei Asaka
    Department of Operative Dentistry, Nihon University School of Dentistry, Tokyo, Japan
    Oper Dent 32:73-8. 2007
    This study investigated the influence of thermal cycling on the dentin bond strengths of single-step self-etch adhesive systems. The Absolute, Clearfil Tri-S Bond, G-Bond and One-Up Bond F Plus systems were used...
  83. ncbi Effect of chemical irrigants on the bond strength of a self-etching adhesive to pulp chamber dentin
    Juliana Nascimento Santos
    Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil
    J Endod 32:1088-90. 2006
    The aim of this study was to evaluate the influence of endodontic irrigants on adhesion to pulp chamber dentin. Seventy crowns of bovine incisors were cut to expose the pulp chamber...
  84. ncbi Remineralization of caries lesions extending into dentin
    J M Ten Cate
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    J Dent Res 80:1407-11. 2001
    ..The aim of this study was to explore whether caries lesions in enamel and extending into the dentin can be remineralized...
  85. ncbi Effect of whitening agents on dentin bonding
    G M Spyrides
    Department of Prosthodontics and Dental Materials, UFRJ Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Esthet Dent 12:264-70. 2000
    ..The aim of this in vitro study was to evaluate the effect of three bleaching regimens: 35% hydrogen peroxide (HP), 35% carbamide peroxide (CP), and 10% CP, on dentin bond strengths.
  86. ncbi Bonding characteristics to dentin walls of class II cavities, in vitro
    S Bouillaguet
    Department of Cariology, Endodontics and Pediatric Dentistry, School of Dental Medicine, University of Geneva, Geneva, Switzerland
    Dent Mater 17:316-21. 2001
    ..e., axial resin-dentin interface). RESULTS: The mean bond strengths obtained in the cavity bonding group were significantly lower (p<0...
  87. ncbi Finite element analysis of stresses in endodontically treated, dowel-restored teeth
    Erik Asmussen
    Department of Dental Materials, Faculty of Health Sciences, School of Dentistry, University of Copenhagen, 20 Nørre Allé, DK 2200 Copenhagen N, Denmark
    J Prosthet Dent 94:321-9. 2005
    ..Endodontically-treated, dowel-restored teeth may experience fracture, but investigations of variables related to fracture are often inconclusive and occasionally contradictory...
  88. ncbi Invasion of dentinal tubules by oral bacteria
    R M Love
    Department of Stomatology, University of Otago School of Dentistry, PO Box 647, Dunedin, New Zealand
    Crit Rev Oral Biol Med 13:171-83. 2002
    Bacterial invasion of dentinal tubules commonly occurs when dentin is exposed following a breach in the integrity of the overlying enamel or cementum...
  89. ncbi The role of matrix metalloproteinases (MMPs) in human caries
    C Chaussain-Miller
    Groupe Matrice Extracellulaire et Biominéralisation, Universite Paris 5, France
    J Dent Res 85:22-32. 2006
    ..MMPs have been suggested to play an important role in the destruction of dentin organic matrix following demineralization by bacterial acids and, therefore, in the control or progression of ..
  90. ncbi Formation of odontoblast-like cells from cultured human dental pulp cells on dentin in vitro
    George T J Huang
    University of Maryland, College of Dental Surgery, Dental School, Department of Endodontics, Prosthodontics and Operative Dentistry, Baltimore, Maryland 21201, USA
    J Endod 32:1066-73. 2006
    ..adult dental pulp cells isolated and cultured in vitro and to examine the cell differentiation potential grown on dentin. We observed that some pulp cells isolated with an enzyme-digestion approach proliferated at a similar rate as the ..
  91. ncbi Effects of endodontic irrigation solutions on mineral content of root canal dentin using ICP-AES technique
    Hale Ari
    Department of Endodontics, Selcuk University Faculty of Dentistry, Konya, Turkey
    J Endod 31:187-9. 2005
    The aim of this in vitro study was to evaluate mineral content of root canal dentin after treatment with several endodontic irrigation solutions. Sixty mandibular anterior teeth extracted for periodontal reasons used...
  92. ncbi Effects of adhesive composition on microtensile bond strength to human dentin
    M F Nunes
    Department of Operative Dentistry, University of North Carolina School of Dentistry, Chapel Hill 27599-7450, USA
    Am J Dent 14:340-3. 2001
    ..the role of adhesive composition (solvent and filler content) on microtensile bond strength (muTBS) to human dentin. MATERIALS AND METHODS: 15 third molars were ground to expose superficial dentin, which was polished to 600-grit...
  93. ncbi One-day bonding effectiveness of new self-etch adhesives to bur-cut enamel and dentin
    Jan De Munck
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Leuven, Belgium
    Oper Dent 30:39-49. 2005
    ..The main objective of this study was to determine the bonding effectiveness to and the interaction with enamel/dentin of three contemporary one- and two-step self-etch adhesives by microtensile bond strength testing (microTBS), Fe-..
  94. ncbi The effect of different irrigating solutions on bond strength of two root canal-filling systems
    Ahmed Abdel Rahman Hashem
    Endodontic Department, Ain Shams University, Cairo, Egypt
    J Endod 35:537-40. 2009
    ..The bond strength of gutta-percha/AH plus was adversely affected by MTAD and MTAD/CHX...
  95. ncbi Effect of medications for root canal treatment on bonding to root canal dentin
    Ali Erdemir
    Selcuk University Faculty of Dentistry, Department of Endodontics, Konya, Turkey
    J Endod 30:113-6. 2004
    ..during endodontic treatment procedures may have an effect on bond strengths of adhesive materials to root canal dentin. The purpose of this in vitro study was to evaluate the effect of various medications on microtensile bond ..
  96. ncbi Biomineralization ability and interaction of mineral trioxide aggregate and white portland cement with dentin in a phosphate-containing fluid
    Jessie F Reyes-Carmona
    Postgraduate program of the Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    J Endod 35:731-6. 2009
    ..This study analyzed the interaction of MTA and white Portland cement with dentin after immersion in phosphate-buffered saline (PBS).
  97. ncbi Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges
    Bart Van Meerbeek
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Belgium
    Oper Dent 28:215-35. 2003
    ..In this paper, the basic bonding mechanism to enamel and dentin of these three approaches is demonstrated by means of ultramorphological and chemical characterization of tooth-..
  98. ncbi Chlorhexidine substantivity in root canal dentin
    Sidney Rosenthal
    Department of Endodontology, University of Connecticut School of Dental Medicine, Farmington, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:488-92. 2004
    ..The purpose of this investigation was to evaluate the substantivity of chlorhexidine (CHX) within a root canal system and to assess how long the CHX remains antimicrobially effective...
  99. ncbi What constitutes dental caries? Histopathology of carious enamel and dentin related to the action of cariogenic biofilms
    E A M Kidd
    GKT Dental Institute, Floor 25, Guy s Tower, London Bridge, London SE1 9RT, England
    J Dent Res 83:C35-8. 2004
    ..The dentin reacts to the stimulus in the biofilm by tubular sclerosis and reactionary dentin.
  100. ncbi Dentin bond strength of two mineral trioxide aggregate-based and one epoxy resin-based sealers
    Eloísa Assmann
    Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Endod 38:219-21. 2012
    This study aimed at evaluating the bond strength to root dentin of 2 mineral trioxide aggregate (MTA)-based sealers (Endo-CPM sealer and MTA Fillapex) and of 1 epoxy resin-based sealer (AH Plus sealer).
  101. ncbi The effect of acidity on dislodgment resistance of mineral trioxide aggregate and bioaggregate in furcation perforations: an in vitro comparative study
    Ahmed Abdel Rahman Hashem
    Endodontic Department, Ain Shams University, Egypt, Cairo
    J Endod 38:245-9. 2012
    ..The aim of this study was to compare the effect of acidic environment on the dislodgement resistance of mineral trioxide aggregate (MTA) and Bioaggregate (Innovative BioCeramix, Vancouver, Canada) when used as perforation repair materials...

Research Grants71

  1. TGF B1'S ROLE IN PRIMARY AND REPARATIVE DENTINOGENESIS
    RENA D SOUZA; Fiscal Year: 2001
    ..The molecular mechanisms of TGF-beta1 action during dentin formation are poorly understood...
  2. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..caused by the interaction of the dental materials (GIC and amalgam) with the dental tissues (enamel and dentin)...
  3. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ..expressing Cre recombinase under the control of specific bone promoters (type 1 collagen, osteocalcin, osterix, dentin matrix protein 1) to develop conditional knockouts of the CaR targeted to bone cell populations at different ..
  4. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..tissue-specific gene regulation during the later stages of tooth development, especially those associated with dentin mineralization...
  5. The Roles of FAM20C (DMP4) in Odontogenesis and Osteogenesis
    Chunlin Qin; Fiscal Year: 2013
    ..provided by applicant): This research proposal focuses on the biological roles of FAM20C (also known as Dentin Matrix Protein 4, DMP4) in the formation of dentin, cementum, enamel and bone...
  6. Stem Cell Based Therapy for Regenerative Endodontics
    George T J Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-term goal of this proposal is to regenerate and repair dental pulp/dentin thereby reducing the need of endodontic procedures...
  7. New composite material design based on studies of tooth-composite and microbial i
    J Paul Santerre; Fiscal Year: 2013
    ..Methods: Bonded resin-dentin specimens will be incubated with simulated human saliva esterase (SHSE) for up to 180-days...
  8. Molecular Regulation of Human Dental Stem Cell Properties
    Cun Yu Wang; Fiscal Year: 2013
    ..When implanted into immunodeficient mice, dental stem cells can form dentin- or cementum-like mineralized tissues or related craniofacial structures...
  9. A Novel Approach for Biomaterials Assisted Regeneration of Pulp-Dentin Complex
    Satish Alapati; Fiscal Year: 2013
    ..in postnatal dental pulp stem cell-based regenerative medicine, with an emphasis on tissue-engineering the pulp-dentin complex...
  10. Establishment of Marmoset iPS-derived Cranial Neural Crest Cells
    Steven Farnsworth; Fiscal Year: 2013
    ..lineage-specific progeny cells make ideal cells for dental regenerative goals such as the regeneration of bone, dentin, dental pulp, whole teeth, and peripheral nerves...
  11. Mechanisms of dental pulp stem cell differentiation into functional endothelium
    JACQUES EDUARDO NOR; Fiscal Year: 2013
    ..However, the impact of stem cel- mediated vasculogenesis on dentin formation is not known...
  12. Modeling Dentin by G Protein Coupled Receptor Signaling
    Orapin V Horst; Fiscal Year: 2013
    ..pursue her long-term goal of creating cell-based therapies and tissue engineering approaches to regenerate the dentin-pulp complex in a manner recapitulating normal development...
  13. Proteomics and Genetics of Enamel and Dentin
    James P Simmer; Fiscal Year: 2013
    Patients with inherited enamel or dentin defects, because of the disfiguring appearance of their teeth, have low self-esteem and perceive themselves as having an inferior quality of life...
  14. Identification and Function of nuDMP1 in Odontoblast Differentiation
    Yongbo Lu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The loss of dentin matrix protein 1 (DMP1) function in humans and mice results in autosomal recessive hypophosphatemic rickets (ARHR), characterized by hypomineralization in dentin and bone, ..
  15. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2010
    ..by regulating the function of HERS which in turn control root morphogenesis, odontoblast differentiation, dentin and cementum production and periodontal ligament formation...
  16. Individual Predoctoral Dental Scientist Fellowship
    Ejvis Lamani; Fiscal Year: 2011
    ..similar phenotype of incomplete or absent root formation is observed in patients with the human disease Radicular Dentin Dysplasia (ROD;MIM125400) also known as Rootless Teeth or Dentin Dysplasia Type I...
  17. Bone Morphogenetic Protein Controls Links Between Dentinogenesis and Angiogenesis
    Audrey Rakian; Fiscal Year: 2013
    ..b>Dentin sialophosphoprotein (DSPP) gene is expressed during terminal differentiation of odontoblasts and is regulated by ..
  18. Osteoblast and Odontoblast Specific Regulatory Action of Runx2 for Bone and Tooth
    MITRA D ADHAMI; Fiscal Year: 2013
    ..acquisition, and that the function of Runx2 in odontoblasts is essential for odontoblast maturation, and proper dentin and tooth formation...
  19. FASEB Summer Research Conference on Osteopontin Biology
    Neal S Fedarko; Fiscal Year: 2010
    ..Other members of the family include bone sialoprotein, dentin matrix protein-1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein...
  20. Dentin Fluoride as a Biomarker for Childhood Fluoride Intake
    JAMES STERN WEFEL; Fiscal Year: 2010
    ..We believe that the dentin fluoride levels found in exfoliated primary second molars can serve as an accurate and useful biomarker to monitor ..
  21. CSF-1 in Dental Biology
    SHERRY L ABBOUD-WERNER; Fiscal Year: 2012
    ..we showed that absence of CSF-1 alters tooth matrix protein expression that, in turn, leads to enamel and dentin defects...
  22. INTRINSICALLY DISORDERED PROTEINS IN BIOMINERALIZATION
    JANET M OLDAK; Fiscal Year: 2013
    ..research is to advance understanding of the role of extracellular matrix protein fragmentation in enamel and dentin, with a focus on the analysis of folding and the degree of disorder in the secondary structures of key proteins ..
  23. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2009
    ..of root development at the morphological, cellular and molecular levels including the mechanisms underlying root dentin, cementum and periodontal ligament formation which leads to root attachment in the healthy periodontium...
  24. Tooth Root Formation: An Emerging Signaling Pathway
    Jian Q Feng; Fiscal Year: 2013
    ..Since dentin forms the bulk of the root, such knowledge is critical for exploring how pulpal cells respond to injury by forming ..
  25. Bone Marrow Stromal Cells in Oral and Craniofacial Tissue Regeneration
    Jake Jinkun Chen; Fiscal Year: 2010
    ..the roles of osterix (Osx), a critical osteogenic transcription factor, in the differentiation of bone- and dentin-forming cells...
  26. Biomodification of Dentin Matrix Structure
    Ana Karina B Bedran-Russo; Fiscal Year: 2013
    ..Despite extensive advances in restorative materials, success in improving the dentin-resin interface and minimizing replacement of restorations has been limited to changes to the material itself...
  27. Reasons for poor durability of resin-dentin bonds
    David H Pashley; Fiscal Year: 2013
    ..A major reason for the poor durability of tooth-colored resin restorations is that collagenolytic MMPs in the dentin matrix are uncovered and activated during resin bonding procedures (Pashley et al., 2004;Tay et al...
  28. Bcl-2, A Key Factor for Dentinogenesis and Tooth Damage Repair
    Wenjian Zhang; Fiscal Year: 2010
    ..With respect to anticipated outcomes, the work will demonstrate the role of odontoblast apoptosis in dentin formation and tooth damage repair...
  29. Analysis of GFP Transgenes in Odontoblast in Differentiation
    Mina Mina; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Reparative dentinogenesis is a regenerative process that leads to dentin bridge formation and the maintenance of the dental pulp vitality...
  30. Generation of human dental epithelial lineage cells from embryonic stem cells
    Yan Zhang; Fiscal Year: 2010
    ..Dental mesenchymal cells adjacent to the dental epithelium, differentiate into odontoblasts, which form dentin. The dental epithelial cells differentiate into ameloblasts that go through multiple stages of differentiation to ..
  31. Key Modulators of Cementogenesis
    Tracy E Popowics; Fiscal Year: 2011
    ..and pyrophosphate (PPi) metabolism is critical for development and maintenance of mineralized tissues, including dentin and cementum...
  32. Noncollagenous Protein Interaction in Biomineralization
    Adele L Boskey; Fiscal Year: 2013
    ..mechanism of deposition of physiologic hydroxyapatite crystals (mineralization) in collagen-based tissues (bone, dentin, cementum, calcified cartilage, etc.) is a poorly understood complex process...
  33. Cell-based scaffold-less three-dimensional construct, a model for dentinogenesis
    FATIMA NAZ SYED-PICARD; Fiscal Year: 2012
    ..Methods are being designed to induce dentin repair and regeneration and more recent research efforts are targeted toward tissue engineering teeth for tooth ..
  34. Role of Notch Signaling in Osteocytes
    Ernesto Canalis; Fiscal Year: 2013
    ..in contrast to the effects observed in osteoblasts, when Notch is expressed in osteocytes under the control of the Dentin matrix protein 1 (Dmp1) promoter it causes a pronounced increase in trabecular and cortical bone volume...
  35. NIDCR Individual Predoctoral Dental Scientist Fellowship
    JOSHUA PADOVANO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant: The inorganic phase in bone and dentin contribute to the unique, compressive strength of these tissues...
  36. Proton Sponge Adhesives, Interfacial Milieu: Molecular Structure-Mechanics
    Paulette Spencer; Fiscal Year: 2013
    ..of composite restorations is particularly vulnerable to decay and at this margin, the adhesive and its seal to dentin provides the primary barrier between the prepared tooth and the environment...
  37. DMP1 Mutations: Defects in Odontogenesis
    Jian Q Feng; Fiscal Year: 2012
    ..In a search for genes required for normal tooth morphogenesis we have studied Dentin matrix protein1 (DMP1), a non- collagenous matrix protein highly expressed in pulp/odontoblast cells, using in ..
  38. Bone Sialprotein in Osteogenesis and Bone Regeneration
    Jinxi Wang; Fiscal Year: 2013
    ..Bone sialoprotein (BSP) is one of the major non-collagenous extracellular matrix (ECM) phosphoproteins in bone and dentin. BSP is highly expressed in developing and postnatal regenerating bone, but its precise function is largely ..
  39. Roles of Dmp1 in dentinogenesis
    Ling Ye; Fiscal Year: 2010
    The candidate is a trained dentist and his research experience is in the fields of dentin and bone developmental biology, where his main interests have been in dentin matrix proteins and bone morphogenetic protein receptors, in vitro/ in ..
  40. Epigenetics of Dental Stem Cells: Markers and CP27 Function
    Xianghong Luan; Fiscal Year: 2010
    ..that give rise to differentiated dental tissues such as periodontal ligament, alveolar bone, cementum, pulp, and dentin, and also serve as a resource for the continuous replenishment of high-turnover tissues such as the periodontal ..
  41. Intracellular and Extracellular function of dentin phosphophoryn
    Anne George; Fiscal Year: 2013
    ..Acidic phosphoproteins of the organic matrix of bone and dentin have been implicated as regulators of the nucleation process and growth of the inorganic calcium phosphate ..
  42. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2013
    ..MMP20 have strikingly malformed dental enamel that is thin, soft, and easily abrades from the underlying dentin. In Mmp20 null mice, the secretory stage ameloblasts do not enter the maturation stage of development properly and,..
  43. DMP1 and DSPP in Osteogenesis and Dentinogenesis
    Albert K Yamoah; Fiscal Year: 2013
    ..Specifically, we are focusing upon the biological functions of dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP)...
  44. Structural and Functional Analysis of Dentin Proteins
    James P Simmer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our long-term goal is to understand the molecular mechanisms of dentin biomineralization. The most abundant and important molecules in dentin are type I collagen and dentin sialophosphoprotein (DSPP)...
  45. Dental Nanocomposite Materials Using Functional Polymer and HAP Nanocrystals
    Seung Wuk Lee; Fiscal Year: 2009
    ..The proposed dental nanocomposite materials with HSP motifs will improve adhesive bonding to dentin and enamel surfaces, durability, toughness, biocompatibility, and aesthetic appearance...
  46. DSP-PP Precursor Protein Processing
    Helena H Ritchie; Fiscal Year: 2013
    Abstract: Dentin sialoprotein (DSP) and phosphophoryn (PP) are the two most abundant noncollagenous proteins in dentin, and have more recently been found in bone, kidney and salivary glands, suggesting that the DSP-PP gene may ..
  47. Regeneration of Clinically Relevant Orofacial Tissues in Pre-Clinical Models
    Jeremy J Mao; Fiscal Year: 2010
    ..tissue engineering of orofacial structures has provided the proof of concept that single tissue fragments, such as dentin and bone, can regenerate in vitro or in small animal models...
  48. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2011
    ..MMP20 have strikingly malformed dental enamel that is thin, soft, and easily abrades from the underlying dentin. In Mmp20 null mice, the secretory stage ameloblasts do not enter the maturation stage of development properly and,..
  49. REGENERATION OF PULP-DENTIN DEVELOPMENT IN IMMATURE PERMANENT TEETH WITH NECROSIS
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..By studying a new and biologically-based method for treating infection and allowing the tooth to continue its development, this project directly addresses a key issue of high relevance to public health. ..
  50. Effects of osteocyte specific Gs alpha signaling on bone mass and hematopoiesis
    PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013
    ..To restrict ablation of Gsa to osteocytes, we used the 10Kb upstream promoter of Dentin Matrix Protein-1 (DMP-1), known to be expressed specifically in osteocytes, to drive the Cre-recombinase in mice ..
  51. PROTEOMICS AND BIOMINERALIZATION OF DENTIN
    Charles Sfeir; Fiscal Year: 2010
    ..This expertise will be applied to the applicant's funded R01 "Dentin Biomineralization" which involves the determination of the difference in phosphorylation patterns and sites of ..
  52. Role of Cilia in Mammalian Tooth Patterning
    COURTNEY JEANNE HAYCRAFT; Fiscal Year: 2010
    ..the mesenchyme differentiates into many cell types including the dental pulp cells and odontoblasts which secrete dentin below the enamel...
  53. Self-assembling Peptide Nanofiber Hydrogels for Delivery of Proteins and Cells
    JEFFREY DALE HARTGERINK; Fiscal Year: 2013
    ..hydrogels intended as an all-purpose scaffold for the regeneration tissue (tested here on the regeneration of the dentin-pulp complex)...
  54. Characterization of DMP1 A Dentin Phosphoprotein
    Anne George; Fiscal Year: 2012
    ..cell-matrix and matrix-matrix are responsible for odontoblast differentiation and the assembly of the mineralized dentin matrix. Problems in the mineralization process are evident in a number of dental pathologies...
  55. Biomimetic remineralization of resin-dentin bonds
    FRANKLIN CHI MENG TAY; Fiscal Year: 2010
    Bonds created to-date by dentin adhesives are imperfect. Current methods of preventing bond degradation invariably leave a zone of resin-sparse, demineralized dentin which is susceptible to creep during function...
  56. Biomimetic Properties of Cementum and its Interfaces
    Sunita P Ho; Fiscal Year: 2010
    ..Investigate structure, chemical composition, mechanical properties of cementum and its interface with root dentin, 3). Investigate strain fields using functional loads on anterior and posterior teeth as a function of age, 4)...
  57. Role and Mechanism of Bone Morphogenetic Protein 2 Action During Dentinogenesis
    Wuchen Yang; Fiscal Year: 2010
    ..Recombinant BMP2 stimulates the secretion of new dentin matrix, and thereby is currently being tested as a molecule for dental reconstruction, as in vital cap therapy...
  58. DSPP signaling in dentinogenesis
    Shuo Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-ranged goal of these studies is to elucidate the mechanism (s) of dentin sialophosphoportein (DSPP) in dentinogenesis and thereby provide new avenues for inducing the repair and regeneration ..
  59. DENTIN STRUCTURE, DEMINERALIZATION AND REMINERALIZATION
    Grayson W Marshall; Fiscal Year: 2013
    ..Enamel remineralization is an accepted phenomenon with established mechanisms, but dentin remineralization strategies are at an early stage of development...
  60. Matrix Component Interactions in Bone, Dentin, and Invertebrate Mineral
    Arthur Veis; Fiscal Year: 2013
    This application is for continuation of our researh program into the mechanism of mineralization in bone and dentin. These studies are important for understanding, in humans, bone and tooth growth, development, tissue remodeling, and ..
  61. APPLICATION OF CLICK CHEMISTRY IN THE DEVELOPMENT OF NOVEL DENTAL ADHESIVES
    Yong Wang; Fiscal Year: 2010
    ..designed novel monomers which when formulated into a dental adhesive will drastically improve the adhesive/dentin bonding, thus significantly extending the longevity of resin-based tooth restorations...
  62. Multifunctional, Non-thermal Plasmas for Long-lasting Dental Adhesion
    Qingsong Yu; Fiscal Year: 2013
    ..to employ new surface/interface chemistries/functionalities induced by non-thermal plasmas for robust and durable dentin adhesion, thus significantly extending the longevity of resin-based tooth restorations...
  63. Oxarane-Acrylate System to Double the Clinical Service Life of Restorative Resins
    H Ralph Rawls; Fiscal Year: 2013
    ..The best performing OASys will be tested in three in vivo biocompatibility models: delayed-type hypersensitivity, oral mucosa irritation, and pulp and dentin response tests. 1
  64. C/EBP Regulation of Dentinogenesis
    John Harrison; Fiscal Year: 2009
    ..of p20C/EBP[unreadable], a naturally occurring dominant negative C/EBP[unreadable] isoform, showed evidence of dentin dysplasia occurring Preferentially on the lingual side of the incisors and in the molar roots...
  65. UTILITY AND CHOICE OF DENTAL TREATMENTS
    Amid Ismail; Fiscal Year: 2001
    ..the proposed study will test the feasibility and construct validity of two methods of measuring utility of dentin regeneration, tooth extraction, and root canal therapy (Healthy Time Equivalent [HTE] and Willingness to Pay [WTP])..
  66. RADIOPAQUE ADHESIVES AND DENTAL RESTORATIVE RESINS
    ISRAEL CABASSO; Fiscal Year: 2000
    ..processing and performance advantages and, when combined with phosphoryl-monomers, they can be made to develop dentin adhesive properties as well. It is the intention to explore the practical possibilities inherent in these advances...
  67. GENE REGULATION OF RAT DENTIN SIALOPROTEIN
    HELENA RITCHIE; Fiscal Year: 2006
    During tooth development, odontoblasts modulate dentin formation by producing a predentin matrix into which additional NCPs are subsequently secreted to initiate the mineralization process so necessary for healthy tooth formation...
  68. X-RAY MICROANALYTICAL STUDY OF FLUORIDE DISTRIBUTION
    JOSEPH GLAWSON; Fiscal Year: 1990
    ..In this effort, the use of glass ionomer cements which bond to enamel and dentin and release fluoride has significant potential...
  69. LASER ACOUSTIC EVALUATION OF DENTAL MATERIALS BONDING
    EVAN GREENER; Fiscal Year: 1993
    ..quantify the filler/matrix interaction in dental composite materials as well as the bonding strength between dentin bonding agent and dentin...
  70. DENTIN SPECIFIC PHOSPHOPROTEINS AND MINERALIZATION
    Mary Macdougall; Fiscal Year: 2000
    The goal of this project is to study the biological function of these dentin-specific phosphoproteins in the process of dentin biomineralization, thereby advancing our overall understanding of the process of odontoblast differentiation ..
  71. CANDIDATE GENES FOR DG1 AND ADAI
    Mary Macdougall; Fiscal Year: 2003
    Relatively little in known about the molecular etiology of the human genetic diseases of enamel and dentin formation: amelogenesis imperfecta (AI), dentinogenesis imperfecta (DGI), and dentin dysplasia (DD)...