dental enamel

Summary

Summary: A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)

Top Publications

  1. pmc Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:973-83. 2004
  2. ncbi Enamel defects and its relation to life course events in primary dentition of Brazilian children: a longitudinal study
    A M B Chaves
    Department of Paediatric Dentistry, Faculty of Dentistry of Pernambuco, Camaragibe, Brazil
    Community Dent Health 24:31-6. 2007
  3. ncbi X-ray microtomographic study of mineral concentration distribution in deciduous enamel
    F S L Wong
    Centre for Oral Growth and Development, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner Street, London, E1 2AD, UK
    Arch Oral Biol 49:937-44. 2004
  4. pmc Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
  5. pmc A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta
    Martin J Barron
    Faculty of Life Sciences and School of Dentistry, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    Hum Mol Genet 19:1230-47. 2010
  6. ncbi Influence of thermal stress on marginal integrity of restorative materials
    Maximiliano Sergio Cenci
    Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Appl Oral Sci 16:106-10. 2008
  7. pmc Remarkable resilience of teeth
    Herzl Chai
    School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7289-93. 2009
  8. ncbi Evaluation of three different scoring systems for dental erosion: a comparative study in adolescents
    Vasileios Margaritis
    Department of Preventive and Community Dentistry, Dental School, National and Kapodistrian University of Athens, 2, Thivon Street, 11527 Goudi, Athens, Greece
    J Dent 39:88-93. 2011
  9. ncbi Fracture in teeth: a diagnostic for inferring bite force and tooth function
    James J W Lee
    Ceramics Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biol Rev Camb Philos Soc 86:959-74. 2011
  10. ncbi Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation
    Kaj Josephsen
    Department of Dental Pathology, Operative Dentistry, and Endodontics, Aarhus University, Aarhus, Denmark
    Am J Physiol Cell Physiol 299:C1299-307. 2010

Detail Information

Publications328 found, 100 shown here

  1. pmc Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:973-83. 2004
    ..Thus, ameloblastin is a cell adhesion molecule essential for amelogenesis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by binding to ameloblasts and inhibiting proliferation...
  2. ncbi Enamel defects and its relation to life course events in primary dentition of Brazilian children: a longitudinal study
    A M B Chaves
    Department of Paediatric Dentistry, Faculty of Dentistry of Pernambuco, Camaragibe, Brazil
    Community Dent Health 24:31-6. 2007
    ..To evaluate the cumulative incidence of enamel defects (ED) and its correlation with life course events such as malnutrition and pre- and postnatal infections, in a cohort of children of low socioeconomic status...
  3. ncbi X-ray microtomographic study of mineral concentration distribution in deciduous enamel
    F S L Wong
    Centre for Oral Growth and Development, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner Street, London, E1 2AD, UK
    Arch Oral Biol 49:937-44. 2004
    ..To determine the mineral concentration distribution in deciduous enamel by quantitative X-ray microtomography (XMT)...
  4. pmc Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
    Enamelin is critical for proper dental enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis imperfecta...
  5. pmc A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta
    Martin J Barron
    Faculty of Life Sciences and School of Dentistry, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    Hum Mol Genet 19:1230-47. 2010
    ..imperfecta (AI) describes a broad group of clinically and genetically heterogeneous inherited defects of dental enamel bio-mineralization...
  6. ncbi Influence of thermal stress on marginal integrity of restorative materials
    Maximiliano Sergio Cenci
    Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Appl Oral Sci 16:106-10. 2008
    ..05). Marginal integrity was more affected in AM restorations under thermal cycling stress, whereas RC and GI ionomer restoration margins were only significantly affected only under longer dwell times...
  7. pmc Remarkable resilience of teeth
    Herzl Chai
    School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7289-93. 2009
    ....
  8. ncbi Evaluation of three different scoring systems for dental erosion: a comparative study in adolescents
    Vasileios Margaritis
    Department of Preventive and Community Dentistry, Dental School, National and Kapodistrian University of Athens, 2, Thivon Street, 11527 Goudi, Athens, Greece
    J Dent 39:88-93. 2011
    ..W.I.), and the Evaluating Index of Dental Erosion (EV.I.D.E.), which are introduced and calibrated in the present study, in order to contribute to the development of a standardised and validated erosion index...
  9. ncbi Fracture in teeth: a diagnostic for inferring bite force and tooth function
    James J W Lee
    Ceramics Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biol Rev Camb Philos Soc 86:959-74. 2011
    ..How the findings impact on dietary pressures forms an undercurrent of the study...
  10. ncbi Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation
    Kaj Josephsen
    Department of Dental Pathology, Operative Dentistry, and Endodontics, Aarhus University, Aarhus, Denmark
    Am J Physiol Cell Physiol 299:C1299-307. 2010
    ....
  11. ncbi Characterization of dentin, enamel, and carious lesions by a polarization-sensitive optical coherence tomography system
    Yueli Chen
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 1157, USA
    Appl Opt 44:2041-8. 2005
    ..e., the local textural features and the global structural features. This study indicates that PSOCT has the potential to be a powerful tool for research of dental formation and caries diagnosis...
  12. pmc Transgenic rescue of enamel phenotype in Ambn null mice
    Y H P Chun
    Department of Biologic and Materials Sciences, University of Michigan, School of Dentistry, 1011 North University, Ann Arbor, MI 48109 1078, USA
    J Dent Res 89:1414-20. 2010
    ..We conclude that ameloblastin is essential for dental enamel formation.
  13. ncbi EPR dosimetry with tooth enamel: A review
    Paola Fattibene
    Istituto Superiore di Sanita, Department of Technology and Health, Viale Regina Elena, Rome, Italy
    Appl Radiat Isot 68:2033-116. 2010
    ..Results of and problems encountered in international intercomparisons and epidemiological studies are also dealt with. In the final section the future of EPR dosimetry with tooth enamel is analyzed...
  14. ncbi Reconditioning of self-ligating brackets
    Maria Francesca Sfondrini
    Department of Orthodontics, University of Pavia, Pavia, Italy
    Angle Orthod 82:158-64. 2012
    ..To test the null hypothesis that there is no significant difference in the shear bond strength (SBS) and Adhesive Remnant Index (ARI) scores of new vs reconditioned self-ligating brackets...
  15. pmc An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
    Ophir D Klein
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 135:377-85. 2008
    ..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...
  16. ncbi Prevention of demineralization around orthodontic brackets in vitro
    Theresia Rini Sudjalim
    School of Dental Science, University of Melbourne, Victoria, Australia
    Am J Orthod Dentofacial Orthop 131:705.e1-9. 2007
    ....
  17. ncbi Structural changes in human dental enamel after subablative erbium laser irradiation and its potential use for caries prevention
    C Apel
    Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Aachen University, Pauwelsstrasse 30, DE 52074 Aachen, Germany
    Caries Res 39:65-70. 2005
    Numerous studies have confirmed the potential of erbium laser irradiation for increasing the acid resistance of dental enamel. The objective of the present paper was to investigate the effect of subablative erbium laser irradiation on ..
  18. ncbi Comparison of body weight and gene expression in amelogenin null and wild-type mice
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Eur J Oral Sci 114:190-3; discussion 201-2, 381. 2006
    ..The smaller size of AmelX null mice could potentially be explained by the lack of LRAP expression in some of these tissues, leading to a delay in development...
  19. pmc Experimental determination of the periodicity of incremental features in enamel
    T M Smith
    Department of Anthropology, Stony Brook University, Stony Brook, NY 11794, USA
    J Anat 208:99-113. 2006
    Vital labelling of hard tissues was used to examine the periodicity of features of dental enamel microstructure...
  20. ncbi Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia in Gja1Jrt/+ mice
    K Toth
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    J Cell Physiol 223:601-9. 2010
    ..Together, these data show that reduced levels of Cx43 gap junctions result in ameloblast dysregulation, enamel hypoplasia, and secondary tissue responses...
  21. ncbi Effects of pH values of hydrogen peroxide bleaching agents on enamel surface properties
    B Xu
    Prosthodontics Department, Wuhan University, Wuhan, China
    Oper Dent 36:554-62. 2011
    ..Bleaching solutions with lower pH values could result in more significant erosion of enamel, which represented a slight whitening effect...
  22. ncbi Hexametaphosphate effects on tooth surface conditioning film chemistry--in vitro and in vivo studies
    Henk J Busscher
    University of Groningen, Department of Biomedical Engineering, Groningen, The Netherlands
    J Clin Dent 13:38-43. 2002
    ..hexametaphosphate and control commercial dentifrices on the surface chemistry of conditioning film-coated dental enamel in vitro and in vivo...
  23. ncbi The protective nature of pellicle towards toothpaste abrasion on enamel and dentine
    Andrew Joiner
    Unilever Oral Care, Quarry Road East, Bebington, Wirral CH63 3JW, United Kingdom
    J Dent 36:360-8. 2008
    ..To determine the protective nature of pellicle towards toothpaste abrasion...
  24. ncbi Shear bond strength of deciduous and permanent bovine enamel
    Maria Francesca Sfondrini
    Department of Orthodontics, University of Pavia, Italy
    J Adhes Dent 13:227-30. 2011
    ..The use of bovine teeth as a substitute for human enamel has been proposed for dental studies. The aim of this study was to determine the shear bond strength and Adhesive Remnant Index (ARI) of deciduous and permanent bovine teeth...
  25. ncbi Dental erosion and soft drink consumption in Swedish children and adolescents and the development of a simplified erosion partial recording system
    Agneta Hasselkvist
    Public Dental Health, Orebro County Council, Orebro, Sweden
    Swed Dent J 34:187-95. 2010
    ..The hypothesis that dental erosion would be higher in boys than girls and that it would show a correlation with soft drink intake was confirmed...
  26. ncbi Mechanisms of action of fluoride for caries control
    Marilia Afonso Rabelo Buzalaf
    Department of Biological Sciences, Orthodontics and Public Health, Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Monogr Oral Sci 22:97-114. 2011
    ..Evidence also supports fluoride's systemic mechanism of caries inhibition in pit and fissure surfaces of permanent first molars when it is incorporated into these teeth pre-eruptively...
  27. ncbi Amelogenin p.M1T and p.W4S mutations underlying hypoplastic X-linked amelogenesis imperfecta
    J W Kim
    Department of Orthodontics and Pediatric Dentistry, University of Michigan Dental Research Lab, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Dent Res 83:378-83. 2004
    ..Dentin was normal. The severity of the enamel phenotype correlated with the predicted effects of the mutations on amelogenin expression and secretion...
  28. ncbi Prevalence of enamel hypoplasia and isolated opacities in the primary dentition
    R L Slayton
    Department of Pediatric Dentistry, University of Iowa, College of Dentistry, USA
    Pediatr Dent 23:32-6. 2001
    ..The purpose of this paper is to report the prevalence of enamel hypoplasia and isolated enamel opacities in a cohort of healthy, well-nourished children in Iowa...
  29. ncbi Dental enamel as a dietary indicator in mammals
    Peter Lucas
    Department of Anthropology, George Washington University, Washington, DC 20052, USA
    Bioessays 30:374-85. 2008
    ..As a tissue with intrinsic weakness yet exceptional durability, enamel could be especially useful as a dietary indicator for extinct taxa...
  30. pmc Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 100:4060-5. 2003
    ..The order of duplication events may help delineate early events in mineralized skeletal formation, which is a major characteristic of vertebrates...
  31. ncbi Prevalence and distribution of developmental enamel defects in primary dentition of Chinese children 3-5 years old
    Y Li
    School of Dentistry, University of Alabama at Birmingham 35294, USA
    Community Dent Oral Epidemiol 23:72-9. 1995
    ..05), and mean EDS (P < 0.05). Children born prematurely were shown to have four times more enamel lesions than children who were full term (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)..
  32. pmc Regulation of dental enamel shape and hardness
    J P Simmer
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 N University, Ann Arbor, MI 48109 1078, USA
    J Dent Res 89:1024-38. 2010
    ..Here we review the growth parameters that determine the shape of the enamel crown as well as the mechanisms of enamel appositional growth and maturation...
  33. ncbi Bond strengths of orthodontic bracket after acid-etched, Er:YAG laser-irradiated and combined treatment on enamel surface
    Bor Shiunn Lee
    Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan ROC
    Angle Orthod 73:565-70. 2003
    ..Er:YAG laser ablation consumed less time compared with the acid-etching technique. Therefore, Er:YAG laser ablation can be an alternative tool to conventional acid etching...
  34. ncbi Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
    Kaori Kubota
    Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23194-202. 2005
    ..Because ameloblasts are responsible for dental enamel formation, we used an ameloblast-derived cell line (LS8) to characterize specific responses to fluoride ..
  35. ncbi Functional ecology and evolution of hominoid molar enamel thickness: Pan troglodytes schweinfurthii and Pongo pygmaeus wurmbii
    Erin R Vogel
    Department of Anthropology, 1156 High Street, University of California Santa Cruz, CA 95064, United States
    J Hum Evol 55:60-74. 2008
    ..These data, which are among the first reported for hominoid primates, fill an important empirical void for evaluating the mechanical plausibility of putative hominin food objects...
  36. ncbi Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges
    Bart Van Meerbeek
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Belgium
    Oper Dent 28:215-35. 2003
    ..Especially "mild," two-step self-etch adhesives that bond through a combined micromechanical and chemical interaction with tooth tissue closely approach conventional three-step systems in bonding performance...
  37. ncbi Nanoindentation mapping of the mechanical properties of human molar tooth enamel
    J L Cuy
    Department of Materials Science and Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Arch Oral Biol 47:281-91. 2002
    The mechanical behavior of dental enamel has been the subject of many investigations. Initial studies assumed that it was a more or less homogeneous material with uniform mechanical properties...
  38. ncbi Biochemical composition and cariogenicity of dental plaque formed in the presence of sucrose or glucose and fructose
    J A Cury
    Faculty of Dentistry of Piracicaba, State University of Campinas, SP, Brazil
    Caries Res 34:491-7. 2000
    ..For each phase, an acrylic resin appliance containing four human dental enamel blocks was constructed for the volunteers...
  39. ncbi In vitro FT-IR study of the effects of hydrogen peroxide on superficial tooth enamel
    Tamas Bistey
    University of Debrecen, Medical and Health Science Center, Faculty of Dentistry, Department of Prosthetic Dentistry, P O Box 13, H 4012 Debrecen, Hungary
    J Dent 35:325-30. 2007
    ..It is hypothesized that infrared spectroscopy is capable of showing alterations in human enamel after peroxide treatment and the alteration in enamel is proportional to peroxide concentration...
  40. ncbi Visual and spectrophotometric shade analysis of human teeth
    S Paul
    Clinic of Fixed and Removable Prosthodontics and Dental Material Sciences, Center for Dental and Oral Medicine, University of Zurich, Plattenstrasse 11, 8028 Zurich, Switzerland
    J Dent Res 81:578-82. 2002
    ..0001). The results suggest that spectrophotometric shade analysis is more accurate and more reproducible compared with human shade assessment...
  41. pmc Genetic basis for the evolution of vertebrate mineralized tissue
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 101:11356-61. 2004
    ..We also suggest that mammalian enamel is distinct from fish enameloid. Their similar nature as a hard structural overlay on exoskeleton and teeth is because of convergent evolution...
  42. pmc Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of placental mammals
    Robert W Meredith
    Department of Biology, University of California Riverside, Riverside, California, United States of America
    PLoS Genet 5:e1000634. 2009
    ..The molecular decay of ENAM parallels the morphological degeneration of enamel in the fossil record of placental mammals and provides manifest evidence for the predictive power of Darwin's theory...
  43. ncbi Laser etching of enamel for direct bonding with an Er,Cr:YSGG hydrokinetic laser system
    Serdar Usumez
    Faculty of Dentistry, Department of Orthodontics, Selcuk University, Konya 42079, Turkey
    Am J Orthod Dentofacial Orthop 122:649-56. 2002
    ..Although laser devices are effectively used in some other areas of dentistry, enamel conditioning with an Er,Cr:YSGG laser cannot be considered a successful alternative to the conventional methods of increasing bond strengths to enamel...
  44. ncbi Differences in bonding to acid-etched or Er:YAG-laser-treated enamel and dentin surfaces
    A Martinez-Insua
    Santiago de Compostela University, Santiago de Compostela, Spain
    J Prosthet Dent 84:280-8. 2000
    ..It has been suggested that they are also useful for preparing dental surfaces for adhesion, but results to date have been controversial...
  45. pmc Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice
    James P Simmer
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 284:19110-21. 2009
    ..Instead, individual crystallites seemed to spill out of the enamel when fractured. These results demonstrate that Klk4 is essential for the removal of enamel proteins and the proper maturation of enamel crystals...
  46. pmc UV effects in tooth enamel and their possible application in EPR dosimetry with front teeth
    S Sholom
    Laboratory of External Exposure Dosimetry, Research Center for Radiation Medicine, Kiev, Ukraine
    Health Phys 98:360-8. 2010
    ..The technique developed here to quantify and subtract the UV contribution to the measured tooth is currently limited to cumulative dose measurements with a component of UV equivalent dose equal to or greater than 300 mGy...
  47. ncbi Comparative analysis of dental enamel polyvinylsiloxane impression and polyurethane casting methods for SEM research
    Jordi Galbany
    Secc Antropologia, Departament de Biologia Animal, Universitat de Barcelona Av Diagonal 645, 08028 Barcelona, Spain
    Microsc Res Tech 69:246-52. 2006
    ..However, positive cast quality is optimal for SEM observation only till the fourth consecutive replica from the original mold, especially at high SEM magnification levels...
  48. ncbi Efficacy of microtensile versus microshear bond testing for evaluation of bond strength of dental adhesive systems to enamel
    Ahmed A El Zohairy
    Department of Operative Dentistry, Faculty of Dentistry, University of Cairo, 1 Saraya El Manial St, Manial, Gizeh 11211, Cairo, Egypt
    Dent Mater 26:848-54. 2010
    ....
  49. ncbi Effect of elapsed time following bleaching on the shear bond strength of composite resin to enamel
    Nimet Unlu
    Department of Operative Dentistry, Faculty of Dentistry, Selcuk University, Konya, Turkey
    J Biomed Mater Res B Appl Biomater 84:363-8. 2008
    ..It is advisable that composite resin application onto bleached enamel surfaces should be delayed at least 24 h for 10% CP and 1 week for 35% HP...
  50. ncbi Enamel extension rate patterns in modern human teeth: two approaches designed to establish an integrated comparative context for fossil primates
    Debbie Guatelli-Steinberg
    Department of Anthropology, The Ohio State University, Columbus, OH 43210, USA
    J Hum Evol 63:475-86. 2012
    ..These latter findings suggest that the distribution of perikymata on the enamel surface provides information about rates of EER decline in lateral enamel, at least in modern humans...
  51. ncbi Cytoskeleton and surface structures of cells directly attached to the tooth in the rat junctional epithelium
    Hiroki Ishikawa
    Department of Pathology, Tokyo Dental College, Chiba, Japan
    J Periodontal Res 40:354-63. 2005
    ..The purpose of this study was to examine cytoskeletal and surface structures of DAT cells that might be involved in migration...
  52. ncbi Enamel and dentin bond strength following gaseous ozone application
    Milena Cadenaro
    Department of Biomedicine, University of Trieste, Trieste, Italy
    J Adhes Dent 11:287-92. 2009
    ..To evaluate the effects of gaseous ozone application on enamel and dentin bond strength produced by two self-etching adhesive systems...
  53. pmc The circadian clock modulates enamel development
    Rodrigo S Lacruz
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Rhythms 27:237-45. 2012
    ..Histological analysis of mineralized dental enamel reveals markings called cross-striations associated with daily increments of enamel formation, as evidenced by ..
  54. ncbi Are low birth weight, intrauterine growth restriction, and preterm birth associated with enamel developmental defects?
    J R O Pinho
    Technical School s Health Care System, Postgraduation Program in Public Health, Federal University of Maranhao, Sao Luis, Maranhao, Brazil
    Pediatr Dent 34:244-8. 2012
    The purpose of this study was to estimate the association between low birth weight and its 2 components, intrauterine growth restriction (IUGR) and preterm birth, with developmental defects of dental enamel (DDE).
  55. ncbi Dental erosion--an overview with emphasis on chemical and histopathological aspects
    A Lussi
    Department of Preventive, Restorative and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland
    Caries Res 45:2-12. 2011
    ..The chemical mechanisms of erosion are also summarised in this review. Special attention is given to the microscopic and macroscopic histopathology of erosion...
  56. ncbi Surface roughness and enamel loss with two microabrasion techniques
    Sonia Saeger Meireles
    Department of Operative Dentistry, Federal University of Paraiba, Joao Pessoa, PB, Brazil
    J Contemp Dent Pract 10:58-65. 2009
    ..The aim of this study was to evaluate and compare the surface roughness and enamel loss produced by two microabrasion techniques...
  57. ncbi Radiation dose estimation by tooth enamel EPR dosimetry for residents of Dolon and Bodene
    Kassym Zhumadilov
    Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    J Radiat Res 47:A47-53. 2006
    ..1+/-45.5 mGy before 1949 while the younger population received up to about 100 mGy with an average value of 11.5+/-37.7 mGy...
  58. ncbi Peroxide bleaching agent effects on enamel surface microhardness, roughness and morphology
    Cristiane Franco Pinto
    Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas
    Braz Oral Res 18:306-11. 2004
    ..Human dental enamel samples were obtained from human third molars and randomly divided into seven groups (n = 11): control, ..
  59. ncbi Effect of fluoride varnish and gel on dental erosion in primary and permanent teeth
    Christiana Murakami
    Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Sao Paulo, Av Lineu Prestes, 2227, 05508 000 Sao Paulo, SP, Brazil
    Arch Oral Biol 54:997-1001. 2009
    ..To assess the effect of a fluoride varnish and gel on the erosive wear of primary and permanent teeth...
  60. ncbi Overexpression of transforming growth factor-beta1 in teeth results in detachment of ameloblasts and enamel defects
    Naoto Haruyama
    Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Oral Sci 114:30-4; discussion 39-41, 379. 2006
    ..We speculate that the altered expression of TGF-beta1 in teeth impacts the adhesion process of ameloblasts to dentin...
  61. ncbi Can the hydrogel form of sodium ascorbate be used to reverse compromised bond strength after bleaching?
    Murat Turkun
    Ege University School of Dentistry, Department of Restorative Dentistry and Endodontics, Izmir, Turkey
    J Adhes Dent 11:35-40. 2009
    ..To assess the effect of the hydrogel form of different concentrations (2.5%, 5%, and 10%) of sodium ascorbate on the shear bond strength of composite after bleaching of the enamel with 10% carbamide peroxide gel...
  62. pmc The developmental clock of dental enamel: a test for the periodicity of prism cross-striations in modern humans and an evaluation of the most likely sources of error in histological studies of this kind
    Daniel Antoine
    Institute of Archaeology, University College London, UK
    J Anat 214:45-55. 2009
    ..Significantly they identify the most likely source of error and the common difficulties encountered in histological studies of this kind...
  63. ncbi Kinematic parameters inferred from enamel microstructure: new insights into the diet of Australopithecus anamensis
    Gabriele A Macho
    Department of Archaeological Science, University of Bradford, Bradford BD7 1DP, UK
    J Hum Evol 58:23-32. 2010
    ..g., during seasonal food shortages. Instead, it is more parsimonious to conclude that the habitual diet of A. anamensis differed considerably from that of either of the extant African great apes...
  64. ncbi Fluoride in dental erosion
    Ana Carolina Magalhaes
    Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Monogr Oral Sci 22:158-70. 2011
    ..Further properly designed in situ or clinical studies are recommended in order to better understand the relative differences in performance of the various fluoride agents and formulations...
  65. ncbi Association between developmental enamel defects in the primary and permanent dentitions
    A J Casanova-Rosado
    Faculty of Dentistry, Autonomous University of Campeche, Campeche, Mexico
    Eur J Paediatr Dent 12:155-8. 2011
    ..To determine if the presence of developmental enamel defects (DED) in the primary dentition is a risk indicator for the presence of DED in the permanent dentition in children with mixed dentition, as well as others factors...
  66. ncbi The diets of early hominins
    Peter S Ungar
    Department of Anthropology, University of Arkansas, Fayetteville, AR 72701, USA
    Science 334:190-3. 2011
    ..g., seeds and nuts) consumption dates to millions of years after the appearance of the earliest probable hominins, and there are no consistent trends in diet change among these species through time...
  67. ncbi Effects of sunlight exposure on the human tooth enamel ESR spectra used for dose reconstruction
    Ling Jiao
    Department of Radiation Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    J Radiat Res (Tokyo) 48:21-9. 2007
    ..8 +/- 0.5 mGy (MJ m(-2))(-1), which corresponds to 19.6 +/- 1.3 mGy h(-1) at the latitude of Hiroshima. Signals S2 and S3 may be used to recognize the effect of solar radiation on the enamel...
  68. pmc Novel WDR72 mutation and cytoplasmic localization
    S K Lee
    Department of Cell and Developmental Biology, Seoul National University, 275 1 Yongon dong, Chongno Gu, Seoul 110 768, Korea
    J Dent Res 89:1378-82. 2010
    ..Expression of WDR72 fused to green fluorescent protein showed a cytoplasmic localization exclusively and was absent from the nucleus. We conclude that WDR72 is a cytoplasmic protein that is critical for dental enamel formation.
  69. ncbi Considerations about enamel microabrasion after 18 years
    Renato Herman Sundfeld
    Department of Restorative Dentistry, Araçatuba Dental School UNESP, Rua José Bonifácio 1193, Sao Paulo, CEP16015 050, Brazil
    Am J Dent 20:67-72. 2007
    ..To review of the current status of enamel microabrasion method and its results 18 years after the development and application of this method...
  70. pmc Enamel hypoplasia in molars of sheep and goats, and its relationship to the pattern of tooth crown growth
    H Kierdorf
    Department of Biology, University of Hildesheim, Hildesheim, Germany
    J Anat 220:484-95. 2012
    ..In these cases, microscopic analysis of tooth sections is required for a correct diagnosis of the hypoplastic enamel defects...
  71. ncbi Developmental defects of enamel in primary teeth: prevalence and associated factors
    Patrícia Corrêa-Faria
    Federal University of Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil
    Int J Paediatr Dent 23:173-9. 2013
    ..Studies on the prevalence of enamel defects in the primary dentition as a whole are scarce, as most investigations examine specific population groups...
  72. pmc Dental caries and enamel defects in very low birth weight adolescents
    S Nelson
    Department of Community Dentistry, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Caries Res 44:509-18. 2010
    ..The purpose of this study was to examine developmental enamel defects and dental caries in very low birth weight adolescents with high risk (HR-VLBW) and low risk (LR-VLBW) compared to full-term (term) adolescents...
  73. ncbi The chemistry of enamel caries
    C Robinson
    University of Leeds, Leeds Dental Institute, Division of Oral Biology, United Kingdom
    Crit Rev Oral Biol Med 11:481-95. 2000
    ..First, substituted hydroxyapatite, the main component of dental enamel, can behave in a very complex manner during dissolution...
  74. ncbi The effect of salivary factors on dental erosion in various age groups and tooth surfaces
    Thanabodi Piangprach
    Section of Dental Public Health, Nonthai Hospital, Nakorn Ratchasima, Thailand
    J Am Dent Assoc 140:1137-43. 2009
    ..To identify factors that may provide a potential protective effect against erosion, the authors compared salivary factors and behavioral aspects in participants in three age groups...
  75. ncbi Effect of blood contamination on shear bond strength of orthodontic brackets and disinclusion buttons
    Maria Francesca Sfondrini
    Department of Orthodontics, University of Pavia, Pavia, Italy
    Br J Oral Maxillofac Surg 49:404-8. 2011
    ..001). Contamination of enamel by blood during bonding lowers the strength of the bond, more so with orthodontic brackets than with bondable buttons...
  76. ncbi Effect of fluoridated bleaching gels on the remineralization of predemineralized bovine enamel in vitro
    Peter Tschoppe
    Department of Operative Dentistry and Periodontology, University School of Dental Medicine, CharitéCentrum 3, Germany
    J Dent 37:156-62. 2009
    ..This study evaluated possible differences regarding the remineralization of predemineralized enamel after exposure to fluoridated or non-fluoridated bleaching gels...
  77. ncbi Enamel properties after tooth bleaching with hydrogen/carbamide peroxides in association with a CPP-ACP paste
    Adriana Alcantara Meira de Vasconcelos
    School of Dentistry, Potiguar University Laureate International Universities, Natal, Brazil
    Acta Odontol Scand 70:337-43. 2012
    ..This study evaluated the impact of bleaching teeth using blends of a CPP-ACP paste (MI Paste; MI) and carbamide/hydrogen peroxides in different proportions on surface properties of bleached enamel...
  78. ncbi Crack arrest within teeth at the dentinoenamel junction caused by elastic modulus mismatch
    Sabine Bechtle
    Institute of Advanced Ceramics, Hamburg University of Technology, Hamburg, Germany
    Biomaterials 31:4238-47. 2010
    ....
  79. ncbi CCAAT/enhancer-binding protein delta (C/EBPdelta) maintains amelogenin expression in the absence of C/EBPalpha in vivo
    Yucheng Xu
    The Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 282:29882-9. 2007
    ....
  80. ncbi The effect of 24h non-stop hydrogen peroxide concentration on bovine enamel and dentine mineral content and microhardness
    S K al-Salehi
    Centre for Biomaterials and Tissue Engineering, Department of Adult Dental Care, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK
    J Dent 35:845-50. 2007
    ..Tooth bleaching agents may adversely affect tooth structure. The aim of this study was to investigate the effect of hydrogen peroxide concentration on mineral loss and microhardness of bovine teeth...
  81. pmc Why does enamel in Klk4-null mice break above the dentino-enamel junction?
    James P Simmer
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Mich, USA
    Cells Tissues Organs 194:211-5. 2011
    ....
  82. ncbi The effect of fluoride therapies on the morphology of bleached human dental enamel
    Stella da Silva Ferreira
    Deparment of Restorative Dentistry, University of Sao Paulo, FOUSP, SP, Brazil
    Microsc Res Tech 74:512-6. 2011
    ..05). SEM qualitative investigation demonstrated that 35% hydrogen peroxide affected human dental enamel morphology, producing porosities, depressions, and superficial irregularities at various degrees...
  83. ncbi Imaging RNA polymerase-amelogenin gene complexes with single molecule resolution using atomic force microscopy
    Neal Crampton
    School of Physics and Astronomy, University of Leeds, and Department of Oral Biology, Leeds Dental Institute, UK
    Eur J Oral Sci 114:133-8; discussion 164-5, 380-1. 2006
    ....
  84. ncbi A possible mechanism of acquired acid resistance of human dental enamel by laser irradiation
    T Oho
    Department of Preventive Dentistry, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    Caries Res 24:86-92. 1990
    ..of optical properties, compositional and structural changes and permeability of lased and unlased human dental enamel. Lased enamel showed a high positive birefringence, suggesting the formation of 'microspaces' in enamel...
  85. ncbi Remaining tooth structure associated with various preparation designs for the endodontically treated maxillary second premolar
    Liang Lin Seow
    Department of Conservative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    Eur J Prosthodont Restor Dent 13:57-64. 2005
    ....
  86. ncbi Effects of in-office and at-home bleaching on human enamel and dentin: an in vitro application of Fourier transform infrared study
    Feride Severcan
    Department of Biology, Middle East Technical University, 06531 Ankara, Turkey
    Appl Spectrosc 62:1274-9. 2008
    ..Therefore, at-home bleaching seems to be much safer than in-office bleaching in terms of molecular variations...
  87. ncbi Potential agents to control enamel caries-like lesions
    F C Rehder Neto
    Department of Restorative Dentistry, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Dent 37:786-90. 2009
    ..To assess whether pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium sodium phosphosilicate (CSP) control artificial caries lesion progression...
  88. pmc Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales
    Robert W Meredith
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Biol Sci 278:993-1002. 2011
    ....
  89. ncbi Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Dev Cell 7:719-30. 2004
    ....
  90. pmc Genetic susceptibility to dental caries on pit and fissure and smooth surfaces
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Caries Res 46:38-46. 2012
    ..001), indicating that genetic factors may exert differential effects on caries risk in PFS versus SMS in the primary dentition...
  91. ncbi Gastric reflux is a significant causative factor of tooth erosion
    W P Holbrook
    University of Iceland, Vatnsmyrarvegi 16, IS 101 Reykjavik, Iceland
    J Dent Res 88:422-6. 2009
    ..4%) was associated with erosion into dentin (P < 0.05). Significant associations were found between erosion and diagnosed reflux disease (OR 2.772; P < 0.005) and daily consumption of acidic drinks (OR 2.232; P < 0.005)...
  92. ncbi Effects of elevated hydrogen peroxide 'strip' bleaching on surface and subsurface enamel including subsurface histomorphology, micro-chemical composition and fluorescence changes
    Hermann Götz
    Institute of Applied Structure and Microanalysis, Medical Faculty, Johannes Gutenberg University, Mainz, Germany
    J Dent 35:457-66. 2007
    ..This study examined the effects of elevated concentration hydrogen peroxide tooth whitening treatments on tooth surface and subsurface integrity...
  93. ncbi A longitudinal study of tooth erosion in adolescents
    H El Aidi
    Department of Preventive and Restorative Dentistry, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500 HB, Nijmegen, Netherlands
    J Dent Res 87:731-5. 2008
    ..0% and was found more frequently in boys than in girls (p = 0.034). The distribution of erosion showed a predominance of occlusal surfaces of molars, especially the mesiobuccal cusp top, and palatal surfaces of upper anterior teeth...
  94. ncbi Beneficial effects of hydroxyapatite on enamel subjected to 30% hydrogen peroxide
    Tao Jiang
    Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China
    J Dent 36:907-14. 2008
    ..To evaluate the effect of combination of hydroxyapatite (HA) and hydrogen peroxide (HP) on color, microhardness and morphology of human tooth enamel...
  95. ncbi In vitro evaluation of ICDAS and radiographic examination of occlusal surfaces and their association with treatment decisions
    Michele B Diniz
    Araraquara School of Dentistry, Unesp Univ Estadual Paulista, Pediatric Dentistry, Sao Paulo, Brazil
    Oper Dent 36:133-42. 2011
    ..The ICDAS was strongly associated with TD. Although the correlation between the ICDAS and BW was lower, it is still valuable in the clinical decision-making process...
  96. ncbi Radiodensity and hardness of enamel and dentin of human and bovine teeth, varying bovine teeth age
    R B Fonseca
    Health Sciences Center, Department of Restorative Dentistry, State University of Londrina, R Pernambuco 540, Londrina 86020 120, PR, Brazil
    Arch Oral Biol 53:1023-9. 2008
    ..001). The use of bovine enamel or dentin should take into consideration the teeth age, but as a general rule it should be recommended to select older bovine teeth due to better chances to find greater similarity with human teeth...
  97. ncbi Influence of dentifrices and dietary components in saliva on wettability of pellicle-coated enamel in vitro and in vivo
    H C van der Mei
    Department of Biomedical Engineering, University of Groningen, Groningen, The Netherlands
    Eur J Oral Sci 110:434-8. 2002
    ....
  98. pmc Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice
    Yasuo Yamakoshi
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48108, USA
    Eur J Oral Sci 119:206-16. 2011
    ..These results support the importance of MMP20 during the secretory stage and of KLK4 during the maturation stage and show there is only limited functional redundancy for these enzymes...
  99. ncbi Prevalence of enamel pearls in teeth from a human teeth bank
    Bruno R Chrcanovic
    Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Borizonte, MG, Brazil
    J Oral Sci 52:257-60. 2010
    ..Enamel pearls are a common observation in molars in general, but are most commonly found in maxillary molars...
  100. ncbi Effect of compounds of Galla chinensis on remineralisation of initial enamel carious lesions in vitro
    J P Chu
    Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu, China
    J Dent 35:383-7. 2007
    ..To evaluate the effect of compounds of Galla chinensis on the remineralisation of initial enamel carious lesions in vitro...
  101. pmc Evidence of intact histatins in the in vivo acquired enamel pellicle
    W L Siqueira
    Schulich Dentistry and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada
    J Dent Res 89:626-30. 2010
    ..The in vitro experiments show that all naturally occurring histatins in the AEP have the potential to provide some level of protection against acid injury...

Research Grants64

  1. LASER EFFECTS ON DENTAL HARD TISSUES
    John Featherstone; Fiscal Year: 2007
    ..3) To test the hypothesis that the addition of a highly absorbing layer of water to the surface of dental enamel during ablation by IR laser irradiation eliminates secondary non-apatite phases of calcium phosphate and ..
  2. Functional Studies of Kallikrein 4
    James P Simmer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kallikrein 4 (Klk4) is a serine protease expressed during dental enamel formation...
  3. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The amelogenin proteins have a fundamental role in development of normal dental enamel. Evidence for this comes from patients with mutations in the amelogenin (AMELX) gene, who have the enamel defect ..
  4. Identification of the gene and protein product responsible for Golgi casein kinas
    STEPHANIE MARIE NUNEZ; Fiscal Year: 2013
    ..causative gene of AI, which would increase our understanding of this genetic disease and the formation of dental enamel in general. To date, GCK has only been characterized biochemically...
  5. Why is Fam83h critical for enamel formation?
    Jan C C Hu; Fiscal Year: 2013
    Inherited diseases of dental enamel formation are grouped under the designation of amelogenesis imperfecta (AI)...
  6. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2013
    ..of matrix metalloproteinase-20 (MMP20) and N- cadherin in ameloblast movement and cell-cell attachment during dental enamel development. MMP20 is essential for dental enamel formation...
  7. Structural determinants of amelogenin function in regulating enamel formation
    Henry C Margolis; Fiscal Year: 2013
    ..should aid in the development of novel approaches for the regeneration and repair of diseased or damaged dental enamel. Given the high prevalence of dental caries, there is a tremendous need for restorative procedures that are ..
  8. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2011
    ..of matrix metalloproteinase-20 (MMP20) and Ncadherin in ameloblast movement and cell-cell attachment during dental enamel development. MMP20 is essential for dental enamel formation...
  9. Laser microdissection for molecular analysis of oral, dental and craniofacial dis
    Xiaofeng Zhou; Fiscal Year: 2010
    ..oral cancer progression and metastasis, 2) DNA damage checkpoint pathways in oral cancer and liver cancer, 3) dental enamel formation and evolution, 4) molecular analysis of stress impaired microbial clearance, 5) ameloblastin ..
  10. Eighth International Symposium on Tooth Enamel: Development, Properties and Patho
    JOHN T WRIGHT; Fiscal Year: 2011
    ..We propose to help address these deficiencies in our understanding of the development and pathology of dental enamel by bringing together a group of internationally renowned and new investigators to present and discuss the ..
  11. Recombinant Amelogenin Matrices for Apatite Nanofibers
    STEFAN FRIEDRICH HABELITZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental enamel forms through a protein controlled mineralization and degradation process with a nanoscale precision that new technologies and human engineering may be able to mimic...
  12. A novel desensitizing paste containing enamel-like crystals
    Scott I Merz; Fiscal Year: 2012
    ..The FA crystals are the same as those found in dental enamel and synthetic polymer which mimics the naked amino acid 3,4 dihydroxyphenylalanine (DOPA) found in the mussel ..
  13. CARBONATOAPATITE FORMATION IN ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1993
    ..The information obtained is valuable to predict the stability of dental enamel in normal and cariogenic environments or under fluoride regimes.
  14. CALCIUM REGULATION IN ORAL HEALTH
    Rodrigo S Lacruz; Fiscal Year: 2013
    ..is a key regulator of a broad range of biological functions and is also a key element in the composition of dental enamel. During the maturation stage of amelogenesis, Ca2+ requirements increase as enamel crystals expand in width ..
  15. Developmental Dynamics of Enamel Formation
    Petros Papagerakis; Fiscal Year: 2010
    ..a mathematical model that generates a 3D computerized reconstruction of the crown by accurately simulating dental enamel growth based upon measurements of the growth and developmental parameters that actually determine crown form...
  16. Oral Health Problems of BPD and VLBW adolescents
    Suchitra Nelson; Fiscal Year: 2005
    ..of enamel defects in the primary dentition, which in turn can lead to increased susceptibility of the dental enamel to dental caries...
  17. Laser Ablation of Dental Hard Tissues
    Daniel Fried; Fiscal Year: 2006
    ..safely and efficaciously for the conservative removal of Dental caries; 2) that the ablation efficiency of Dental enamel at erbium laser wavelengths can be increased significantly by using a pulse duration more commensurate with ..
  18. ALTERNATIVE SPLICING OF MOUSE AMELGENINS
    James Simmer; Fiscal Year: 1999
    ..imperfecta (AI) is a heterogeneous group of genetic disorders that are manifested primarily as defects in dental enamel formation. The genetic basis for a human X-linked form of AI is a mutation in the amelogenin gene...
  19. PORCINE ENAMEL PROTEINS
    Jan Hu; Fiscal Year: 2001
    ..Adapted from investigator's Abstract) The long term objectives are to determine the molecular mechanisms of dental enamel formation and to identify the genes responsible for amelogenesis imperfecta (AI)...
  20. GORDON RESEARCH CONFERENCE ON CALCIUM PHOSPHATES, 1992
    ROY WUTHIER; Fiscal Year: 1992
    ..mechanisms in mineralization of dental systems; (5) regulation of calcium phosphate dissolution in dental enamel; (6) mechanisms in pathological deposition of calcium phosphates; (7) physicochemical considerations in ..
  21. ULTRASTRUCTURAL HISTOPATHOLOGY OF HUMAN DENTAL ENAMEL
    JAMES SIMMELINK; Fiscal Year: 1993
    ..Finally, genetically defective human enamel will be compared with controls for crystal and matrix alterations. Results will have relevance in developing the optimal environment for enamel caries resistance without fluorosis...
  22. TERTIARY STRUCTURES OF SALIVARY PROTEINS
    MARK LAMKIN; Fiscal Year: 1993
    ..significant amount of protein proteins and may be selectively adsorbed onto the hydroxyapatite-like surface of dental enamel. Once adsorbed onto the tooth surface, these proteins may be involved in the demineralization/remineralization ..
  23. QUANTITATION OF ENAMEL DEMINERALIZATION MECHANISMS
    William Higuchi; Fiscal Year: 2005
    ..proposes to do basic studies of the anomalous solubility behavior of carbonated apatites (CAPs) and human dental enamel (HE) with the general objective of establishing how the solubility depends on the composition of the mineral ..
  24. SEALANTS HAVING REDUCED LEVELS OF EXTRACTABLE ORGANICS
    FRANCIS KEOHAN; Fiscal Year: 2000
    ..The ultimate objective is to develop an easily processed sealant with high adhesion to Dental enamel and superior durability in this demanding application...
  25. DEVELOPMENT OF A SUBSTRATE FOR TESTING DENTAL ADHESION
    Paulette Spencer; Fiscal Year: 1993
    ..The natural apatite will be dental enamel collected from magnesium-treated rats...
  26. PROTEINASES IN DEVELOPING ENAMEL MATRIX
    Pamela DenBesten; Fiscal Year: 1991
    ..The long-term objective of this proposal is to investigate these proteinases found in developing dental enamel. The specific aims of this proposal include the following: (1) to isolate and purify proteinases found in the ..
  27. VESICLES AND ENDOCHONDRAL BONE FORMATION
    Ellis Golub; Fiscal Year: 1999
    ..formation and growth of hydroxyapatite crystals in the matrix of vertebrate mineralized tissues which include dental enamel, dentin, calcified cartilage and bone...
  28. CARIOGENIC POTENTIAL OF DENTAL PLAQUE
    HENRY MARGOLIS; Fiscal Year: 1990
    ..Thus, the degree of saturation of plaque with respect to dental enamel is a critical determinant for the formation of carious lesions, yet factors influencing this property are ..
  29. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
    ..application is to characterize the role that the matrix metalloproteinase enamelysin (MMP-20) plays during dental enamel and tooth development...
  30. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
  31. ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATION
    JANET OLDAK; Fiscal Year: 2008
    ..processing of the enamel extracellular matrix components is essential for the understanding of pathological dental enamel formation and is one of the critical steps towards the development of enamel-inspired biomimetic materials...
  32. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  34. AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTH
    JANET OLDAK; Fiscal Year: 2002
    ....
  35. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
    b>Dental enamel is the hardest tissue in the body. The enamel organic matrix, secreted by ameloblasts, is composed primarily of amelogenin proteins, which have an important role in enamel mineral crystal growth...
  36. ENAMEL MATRIX SERINE PROTEINASE 1
    James Simmer; Fiscal Year: 2004
    ..EMSP1 is believed to be critical for proper dental enamel formation and defects in the human EMSP1 gene are suspected of causing amelogenesis imperfecta...
  37. ENAMEL MATRIX PROTEIN INTERACTION
    MICHAEL LANSDELL PAINE; Fiscal Year: 2010
    ..For tooth regeneration to become a reality, the protein- protein interactions involving the key dental proteins must be known and understood. ..
  38. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  39. ENAMEL WITHOUT ENAMELIN
    Jan Hu; Fiscal Year: 2007
    ..Without Enamelin: Our long-term objective is to understand the molecular mechanisms of normal and diseased dental enamel formation. Mutations in the human enamelin gene cause autosomal dominant amelogenesis imperfecta...
  40. TIP39KDA AND TOOTH FORMATION
    Michael Paine; Fiscal Year: 2007
    ..The fifth specific aim will answer a very basic question related to how TIP39kDa is processed post-transcriptionally, and the potential significance of this. [unreadable] [unreadable] [unreadable] [unreadable]..
  41. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  42. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2005
    ....
  43. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  44. STEM CELLS AND PERIODONTAL BIOENGINEERING
    THOMAS DIEKWISCH; Fiscal Year: 2007
    ..3. To test the conditions necessary to differentiate stem cells into periodontal cells in vitro. 4. To ask the question whether stem cells will mimic existing periodontal tissues following tissue implantation. ..
  45. Optically enhanced dental sealants to indicate placement and material condition
    George Stookey; Fiscal Year: 2006
    ..unreadable] 3) An optically doped sealant combines the efficacy advantages of a clear sealant with the visibility advantages of an opaque sealant. [unreadable] [unreadable]..
  46. CP 27 GENE FUNCTION IN TOOTH DEVELOPMENT
    THOMAS DIEKWISCH; Fiscal Year: 2004
    ..Understanding the function of CP27 may provide the basis for the development of novel clinical aids for craniofacial diseases. ..
  47. GENETIC DETERMINANTS OF ISOLATED CLEFT PALATE IN MICE
    ERIC EVERETT; Fiscal Year: 2002
    ..abstract_text> ..
  48. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2006
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. [unreadable] [unreadable]..
  49. Clinical Models Workshop:Remin-Demin, Precavity, Caries
    George Stookey; Fiscal Year: 2005
    ..The meeting will be held on July 3-5, 2005 in the Downtown Marriott Hotel in Indianapolis, Indiana, immediately prior to the annual ORCA (European Organization for Caries Research) meeting. ..
  50. BIOLOGY AND BIOMETRICS OF ENAMEL CRYSTAL GROWTH
    THOMAS DIEKWISCH; Fiscal Year: 2005
    ..understanding of the structure-function relationships of amelogenin, the most abundant protein in developing dental enamel. Previously we have demonstrated that amelogenin forms complex 3-dimensional suprastructures intimately linked ..
  51. Development of a P.gingivalis vaccine
    Eric Reynolds; Fiscal Year: 2006
    ..The recombinant proteins, protein fragments and synthetic peptide multivalent constructs will be tested as defined vaccines against P. gingivalis in murine models of disease. ..
  52. Oral Health Outcomes of Early Childhood Malnutrition
    Walter Psoter; Fiscal Year: 2006
    ..Given the universality of PEM pathophysiology, this study's findings will be generalizable to subsets of U.S. children having 9 oral health disparities. [unreadable] [unreadable]..
  53. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..gingivalis, T. denticola, B. forsythus and F. nucleatum grown in monoculture and as polymicrobial cultures using 2D-gel electrophoresis, mass spectrometry and Western blotting. ..
  54. Development of QLF Handpiece for Early Caries Detection
    George Stookey; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  55. BUILDING A TOOTH: The Chicago Blueprint for Dental Regeneration
    THOMAS DIEKWISCH; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  56. Caries Risk Assessment Instrument for Young Adults
    George Stookey; Fiscal Year: 2005
    ..Future large-scale investigations will be undertaken to validate the merits of the instrument. ..
  57. Alabama Dental Practice Research Network Development
    GREGG GILBERT; Fiscal Year: 2005
    ..abstract_text> ..
  58. Oral Health/OHRQOL among low-SES rural adults
    GREGG GILBERT; Fiscal Year: 2004
    ....
  59. Neovascular Regression for Oral Cancer Therapy
    Jacques Nor; Fiscal Year: 2006
    ....
  60. CSF-1 GENE EXPRESSION IN OSTEOCLAST BIOLOGY
    SHERRY ABBOUD WERNER; Fiscal Year: 2009
    ..abstract_text> ..
  61. Bcl-2 and CXC Chemokines in Head /Neck Tumor Angiogenesis /Metastasis
    Jacques Nor; Fiscal Year: 2008
    ..abstract_text> ..
  62. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2005
    ..abstract_text> ..
  63. Glucosyltransferase as a Marker for Caries Activity
    William Bowen; Fiscal Year: 2005
    ..Our eventual goal (in a future application) is to determine caries risk well before the onset of lesions and to identify those who are caries active short of cavitation or even white spot formation. ..
  64. Dentino-enamel junction genetic-structural correlation
    Shane White; Fiscal Year: 2005
    ..abstract_text> ..