tooth

Summary

Top Publications

  1. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
  2. ncbi Tooth shape formation and tooth renewal: evolving with the same signals
    Jukka Jernvall
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, FIN 00014, Finland
    Development 139:3487-97. 2012
  3. ncbi Adaptive radiation of multituberculate mammals before the extinction of dinosaurs
    Gregory P Wilson
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    Nature 483:457-60. 2012
  4. ncbi Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice
    R N D'Souza
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 126:2911-20. 1999
  5. ncbi Expression of Wnt signalling pathway genes during tooth development
    L Sarkar
    Department of Craniofacial Development, Guy s Tower, Guy s, Kings and St Thomas Schools of Medicine, Dentistry and Biomedical Sciences, Floor 28, Guy s Tower, London Bridge, London SE1 9RT, UK
    Mech Dev 85:197-200. 1999
  6. ncbi Dental microwear texture analysis shows within-species diet variability in fossil hominins
    Robert S Scott
    1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
    Nature 436:693-5. 2005
  7. ncbi The development of a bioengineered organ germ method
    Kazuhisa Nakao
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278 8510, Japan
    Nat Methods 4:227-30. 2007
  8. pmc Insights into the ecology and evolutionary success of crocodilians revealed through bite-force and tooth-pressure experimentation
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 7:e31781. 2012
  9. ncbi Quantification of dental microwear by tandem scanning confocal microscopy and scale-sensitive fractal analyses
    Peter S Ungar
    Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Scanning 25:185-93. 2003
  10. pmc Can dental microwear textures record inter-individual dietary variations?
    Gildas Merceron
    UMR CNRS 5125, Paléoenvironnements et Paléobiosphère, Campus de la Doua, Universite Claude Bernard Lyon 1, Villeurbanne, France
    PLoS ONE 5:e9542. 2010

Detail Information

Publications294 found, 100 shown here

  1. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    During mammalian tooth development, the oral ectoderm and mesenchyme coordinate their growth and differentiation to give rise to organs with precise shapes, sizes and functions...
  2. ncbi Tooth shape formation and tooth renewal: evolving with the same signals
    Jukka Jernvall
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, FIN 00014, Finland
    Development 139:3487-97. 2012
    ..Here, we review the developmental mechanisms underlying changes in tooth complexity and tooth renewal during evolution, focusing on recent studies of fish, reptiles and mammals...
  3. ncbi Adaptive radiation of multituberculate mammals before the extinction of dinosaurs
    Gregory P Wilson
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    Nature 483:457-60. 2012
    ..Similar broad-scale ecomorphological inventories of other radiations may help to constrain the possible causes of mass extinctions...
  4. ncbi Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice
    R N D'Souza
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
    Development 126:2911-20. 1999
    ..Here we describe results of studies aimed at understanding the functions of Cbfa1 in tooth formation...
  5. ncbi Expression of Wnt signalling pathway genes during tooth development
    L Sarkar
    Department of Craniofacial Development, Guy s Tower, Guy s, Kings and St Thomas Schools of Medicine, Dentistry and Biomedical Sciences, Floor 28, Guy s Tower, London Bridge, London SE1 9RT, UK
    Mech Dev 85:197-200. 1999
    ..Wnt-3 also showed no expression in the epithelial cells of the molar bud stage tooth germs, but showed restricted expression in the enamel knots which are signalling centres believed to be involved ..
  6. ncbi Dental microwear texture analysis shows within-species diet variability in fossil hominins
    Robert S Scott
    1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
    Nature 436:693-5. 2005
    ..Dental microwear, the study of microscopic tooth-wear resulting from use, provides direct evidence of what an individual ate in the past...
  7. ncbi The development of a bioengineered organ germ method
    Kazuhisa Nakao
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278 8510, Japan
    Nat Methods 4:227-30. 2007
    ..The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a ..
  8. pmc Insights into the ecology and evolutionary success of crocodilians revealed through bite-force and tooth-pressure experimentation
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 7:e31781. 2012
    ..How these factors relate to biomechanical performance during feeding and their relevance to crocodilian evolutionary success are not known...
  9. ncbi Quantification of dental microwear by tandem scanning confocal microscopy and scale-sensitive fractal analyses
    Peter S Ungar
    Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Scanning 25:185-93. 2003
    ..The usual procedure involves imaging tooth wear surfaces by scanning electron microscopy (SEM)...
  10. pmc Can dental microwear textures record inter-individual dietary variations?
    Gildas Merceron
    UMR CNRS 5125, Paléoenvironnements et Paléobiosphère, Campus de la Doua, Universite Claude Bernard Lyon 1, Villeurbanne, France
    PLoS ONE 5:e9542. 2010
    ..Focusing on a finer, intra-specific scale of analysis, the aim of this study is to test this method's ability to track such differences between individuals from a single population...
  11. ncbi Evaluation of the validity of tooth size and arch width measurements using conventional and three-dimensional virtual orthodontic models
    Oded Zilberman
    Division of Orthodontics, Department of Odontology, Karolinska Institutet, Stockholm, Sweden
    Angle Orthod 73:301-6. 2003
    ..Measurements of mesiodistal tooth dimension as well as intercanine and intermolar width were made on both...
  12. ncbi Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
    H R Dassule
    The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 202:215-27. 1998
    ..During the early stages of tooth development, a local ectodermal thickening which expresses several signaling molecules appears...
  13. pmc Ecological changes in Miocene mammalian record show impact of prolonged climatic forcing
    Catherine Badgley
    Museum of Paleontology and Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:12145-9. 2008
    ..These results are evidence for long-term climatic forcing of vegetation structure and mammalian ecological diversity at the subcontinental scale...
  14. ncbi Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
    Youngwook Ahn
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Development 137:3221-31. 2010
    Mice carrying mutations in Wise (Sostdc1) display defects in many aspects of tooth development, including tooth number, size and cusp pattern...
  15. pmc Implications of diet for the extinction of saber-toothed cats and American lions
    Larisa R G DeSantis
    Department of Earth and Environmental Science, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 7:e52453. 2012
    ..difficult at La Brea (California) during the late Pleistocene, as nearly all carnivores have greater incidences of tooth breakage (used to infer greater carcass utilization) compared to today...
  16. pmc Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors
    Emma Juuri
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Cell 23:317-28. 2012
    ..Sox2+ cells became restricted to the labial cervical loop during tooth morphogenesis, and they contributed to the renewal of enamel-producing ameloblasts as well as all other epithelial ..
  17. pmc Tooth dentin defects reflect genetic disorders affecting bone mineralization
    S Opsahl Vital
    Dental School University Paris Descartes PRES Sorbonne Paris Cité, EA 2496, Montrouge, F 92120, France
    Bone 50:989-97. 2012
    ..In conclusion, dentin constitutes a valuable tool for better understanding of the pathological processes affecting biomineralization...
  18. pmc Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages
    Maria Jussila
    Developmental Biology Program Institute of Biotechnology, Biokeskus 1, P O Box 56, University of Helsinki, Helsinki FIN 00014, Finland
    Cold Spring Harb Perspect Biol 4:a008425. 2012
    Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth organogenesis is regulated by an intricate network of cell-cell signaling during all steps of development...
  19. pmc Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling
    Cyril Charles
    Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, CA 94143, USA
    Development 138:4063-73. 2011
    ..As mammals entered new ecological niches, many changes in tooth number occurred, presumably as adaptations to new diets...
  20. ncbi Tooth hardness increases with zinc-content in mandibles of young adult leaf-cutter ants
    Robert M S Schofield
    Department of Physics, University of Oregon, Eugene, OR 97403, USA
    Naturwissenschaften 89:579-83. 2002
    ..Zinc enrichment (along with enrichment by other heavy metals and halogens) may play an unrecognized role in the behavioral ecology and evolution of a wide variety of invertebrates...
  21. ncbi Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme
    Paivi Kettunen
    Division of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Development 132:323-34. 2005
    During development, trigeminal nerve fibers navigate and establish their axonal projections to the developing tooth in a highly spatiotemporally controlled manner...
  22. ncbi Mechanisms of ectodermal organogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 262:195-205. 2003
    ..Here the current knowledge on the molecular regulation of the initiation, placode formation, and morphogenesis of ectodermal organs is discussed with emphasis on feathers, hair, and teeth...
  23. ncbi Stem cells for tooth engineering
    G Bluteau
    Department of Orofacial Development and Structure, Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, Plattenstrasse 11, CH 8032 Zurich, Switzerland
    Eur Cell Mater 16:1-9. 2008
    b>Tooth development results from sequential and reciprocal interactions between the oral epithelium and the underlying neural crest-derived mesenchyme...
  24. ncbi Bioengineered teeth from cultured rat tooth bud cells
    M T Duailibi
    University Federal of São Paulo, Department of Otorhinolaryngology and Human Communication Disorders, Sao Paolo, Brazil
    J Dent Res 83:523-8. 2004
    The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues...
  25. pmc Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
    ..These results demonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organization and mineralization...
  26. ncbi Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
    C R Lin
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 401:279-82. 1999
    ..cardiac position, arrest in turning and, subsequently, a block in the determination and proliferation events of anterior pituitary gland and tooth organogenesis. Thus, Pitx2 is a transcription factor that encodes 'leftness' of the lung.
  27. pmc Fully functional bioengineered tooth replacement as an organ replacement therapy
    Etsuko Ikeda
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Proc Natl Acad Sci U S A 106:13475-80. 2009
    ..Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar ..
  28. pmc Molecular genetics of tooth development
    Marianna Bei
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston MA 02129, USA
    Curr Opin Genet Dev 19:504-10. 2009
    ..b>Tooth development is an excellent context for investigating this complex problem because of the wealth of information ..
  29. pmc Sox2 marks epithelial competence to generate teeth in mammals and reptiles
    Emma Juuri
    Institute of Biotechnology, Developmental Biology Program, University of Helsinki, 00014 Helsinki, Finland
    Development 140:1424-32. 2013
    b>Tooth renewal is initiated from epithelium associated with existing teeth...
  30. pmc The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition
    Myrto Denaxa
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 333:324-36. 2009
    ..Our experiments demonstrate that the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for craniofacial development and patterning of mammalian dentition...
  31. pmc FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice
    Klaus Kratochwil
    Institute of Molecular Biology, Austrian Academy of Sciences, 5020 Salzburg, Austria
    Genes Dev 16:3173-85. 2002
    ..In previous tissue recombination experiments with normal and Lef1(-/-) tooth germs, we found that the effect of LEF1 expression in the epithelium is tissue nonautonomous and transferred to ..
  32. ncbi Dental lamina as source of odontogenic stem cells: evolutionary origins and developmental control of tooth generation in gnathostomes
    Moya M Smith
    KCL, Dental Institute, London, United Kingdom
    J Exp Zool B Mol Dev Evol 312:260-80. 2009
    This study considers stem cells for odontogenic capability in biological tooth renewal in the broad context of gnathostome dentitions and the derivation of them from oral epithelium...
  33. ncbi Tissue engineered hybrid tooth-bone constructs
    Weibo Zhang
    Division of Craniofacial and Molecular Genetics, Department of Oral and Maxillofacial Pathology, Tufts University, 136 Harrison Avenue, Room M824, Boston, MA 02111, USA
    Methods 47:122-8. 2009
    ..since teeth naturally grow in coordination with the craniofacial skeleton, our group developed an autologous, tooth-bone hybrid model to facilitate repair of mandibular defects in the Yucatan minipig...
  34. pmc First complete sauropod dinosaur skull from the Cretaceous of the Americas and the evolution of sauropod dentition
    Daniel Chure
    Dinosaur National Monument, P O Box 128, Jensen, UT 84035, USA
    Naturwissenschaften 97:379-91. 2010
    ..45 million years earlier and had substantially broader teeth. A survey of tooth shape in sauropodomorphs demonstrates that sauropods evolved broad crowns during the Early Jurassic but did not ..
  35. ncbi High-level similarity of dentitions in carnivorans and rodents
    Alistair R Evans
    Evolution and Development Unit, Institute of Biotechnology, PO Box 56 Viikinkaari 9, FIN 00014 University of Helsinki, Finland
    Nature 445:78-81. 2007
    The study of mammalian evolution depends greatly on understanding the evolution of teeth and the relationship of tooth shape to diet...
  36. ncbi Reptilian tooth development
    Joy M Richman
    Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
    Genesis 49:247-60. 2011
    ..Despite this great variation, most of our understanding of tooth development is derived from studies on just a few model organisms...
  37. ncbi Comparison of body weight and gene expression in amelogenin null and wild-type mice
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Eur J Oral Sci 114:190-3; discussion 201-2, 381. 2006
    ..The smaller size of AmelX null mice could potentially be explained by the lack of LRAP expression in some of these tissues, leading to a delay in development...
  38. ncbi Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury
    T A Mitsiadis
    Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London, UK
    J Dent Res 83:896-902. 2004
    ..In this review, we discuss what is known about the molecular mechanisms involved in dental repair...
  39. ncbi Childhood obesity and dental development
    Kelly K Hilgers
    Department of Pediatric Dentistry, Arizona School of Dentistry and Oral Health, Mesa, Ariz, USA
    Pediatr Dent 28:18-22. 2006
    ..The purpose of this study was to determine if increased body mass index (BMI) is associated with accelerated dental development in children ages 8 to 15...
  40. pmc Abnormalities in the enamel in bmp2-deficient mice
    Junsheng Feng
    The University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
    Cells Tissues Organs 194:216-21. 2011
    b>Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation...
  41. pmc Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation
    Benjamin B Williams
    Department of Diagnostic Radiology, Dartmouth Physically based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA
    Int J Radiat Biol 87:766-75. 2011
    ..In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel has been developed to meet this need.
  42. pmc Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy
    Scott W Rogers
    Geriatric Research, Education and Clinical Center, Veteran s Administration, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e36467. 2012
    ..The expression of alpha7GFP also identifies all stages of innervation of the tooth organ...
  43. pmc Monitoring DNA contamination in handled vs. directly excavated ancient human skeletal remains
    Elena Pilli
    Dipartimento di Biologia Evoluzionistica Laboratori di Antropologia, Universita di Firenze, Firenze, Italy
    PLoS ONE 8:e52524. 2013
    ..In addition, we showed that bones can also be a good candidate for human aDNA analysis if they come directly from the excavation site and are accompanied by a clear taphonomic history...
  44. ncbi Making a tooth: growth factors, transcription factors, and stem cells
    Yan Ding Zhang
    College of Stomatology, Wuhan University, Wuhan, China
    Cell Res 15:301-16. 2005
    Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-mesenchymal interactions...
  45. pmc Epithelial-specific requirement of FGFR2 signaling during tooth and palate development
    Ryoichi Hosokawa
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Exp Zool B Mol Dev Evol 312:343-50. 2009
    ..K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate...
  46. ncbi Possible involvement of melatonin in tooth development: expression of melatonin 1a receptor in human and mouse tooth germs
    Shuku Kumasaka
    Second Department of Oral and Maxillofacial Surgery, Department of Oral Medicine, School of Dental Medicine, Tsurumi University, 2 1 3 Tsurumi, Tsurumi ku, Yokohama, Kanagawa, 230 8501, Japan
    Histochem Cell Biol 133:577-84. 2010
    ..However, little is known about the effects of melatonin on tooth development and growth, which thus remain to be elucidated...
  47. pmc Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation
    Akira Sonoda
    Section of Pediatric Dentistry, Division of Oral Health, Growth and Development, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 284:27176-84. 2009
    ....
  48. ncbi Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning
    Paivi Kettunen
    Section of Anatomy and Cell Biology, Department of Biomedicine, Medical Faculty, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Mech Dev 124:868-83. 2007
    Dental trigeminal nerve fiber growth and patterning are strictly integrated with tooth morphogenesis, but it is still unknown, how these two developmental processes are coordinated...
  49. ncbi Analysis of tooth movement in extraction cases using three-dimensional reverse engineering technology
    Bong Kuen Cha
    Department of Orthodontics, College of Dentistry, Kangnung National University, Gangneung, South Korea
    Eur J Orthod 29:325-31. 2007
    ..cephalometric superimpositions are currently the most widely used means for assessing sagittal and vertical tooth movements...
  50. pmc BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development
    Lu Li
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 349:451-61. 2011
    The BMP signaling plays a pivotal role in the development of craniofacial organs, including the tooth and palate. BmprIa and BmprIb encode two type I BMP receptors that are primarily responsible for BMP signaling transduction...
  51. ncbi Fracture in teeth: a diagnostic for inferring bite force and tooth function
    James J W Lee
    Ceramics Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biol Rev Camb Philos Soc 86:959-74. 2011
    ..that observations of such cracking can be used as a diagnostic tool for predicting bite force and inferring tooth function in living and fossil mammals...
  52. ncbi Structure and function of the tooth-epithelial interface in health and disease
    Marja T Pöllänen
    Periodontol 2000 31:12-31. 2003
  53. pmc Stem cell-based biological tooth repair and regeneration
    Ana Angelova Volponi
    Department of Craniofacial Development and MRC Centre for Transplantation, Kings College London, London, UK
    Trends Cell Biol 20:715-22. 2010
    ..Stem cells in other parts of the tooth, such as the periodontal ligament and growing roots, play more dynamic roles in tooth function and development...
  54. ncbi Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004
    ..However, deletion of the Dmp-1 gene has little effect on tooth development during embryogenesis...
  55. pmc Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis
    Fei Liu
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Biol 313:210-24. 2008
    Wnt/beta-catenin signaling plays key roles in tooth development, but how this pathway intersects with the complex interplay of signaling factors regulating dental morphogenesis has been unclear...
  56. pmc Primary cilia regulate Shh activity in the control of molar tooth number
    Atsushi Ohazama
    Department of Craniofacial Development, Dental Institute, King s College London, London SE1 9RT, UK
    Development 136:897-903. 2009
    ..to loss of polaris activity in the mesenchyme since loss of Polaris in the epithelium has no detrimental affect on tooth development...
  57. ncbi Genetic basis of tooth agenesis
    Pekka Nieminen
    Institute of Dentistry, Biomedicum, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:320-42. 2009
    b>Tooth agenesis or hypodontia, failure to develop all normally developing teeth, is one of the most common developmental anomalies in man...
  58. pmc Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy
    Masamitsu Oshima
    Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    PLoS ONE 6:e21531. 2011
    ..In this proof of concept study, we here report a further development in this regard in which a bioengineered tooth unit comprising mature tooth, periodontal ligament and alveolar bone, was successfully transplanted into a ..
  59. ncbi Medication effects on the rate of orthodontic tooth movement: a systematic literature review
    Theodosia Bartzela
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Orthod Dentofacial Orthop 135:16-26. 2009
    ..However, the effects of medications on the rate of orthodontic tooth movement have not been evaluated.
  60. ncbi Amelogenin-deficient mice display an amelogenesis imperfecta phenotype
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:31871-5. 2001
    ..the hardest tissue in the body and cannot be replaced or repaired, because the enamel secreting cells are lost at tooth eruption...
  61. ncbi Tooth colour: a review of the literature
    Andrew Joiner
    Unilever Oral Care, Quarry Road East, Bebington, Wirral, UK
    J Dent 32:3-12. 2004
    To review current knowledge with respect to tooth colour and its measurement.
  62. ncbi The importance of signal pathway modulation in all aspects of tooth development
    Mark Tummers
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:309-19. 2009
    Most characteristics of tooth shape and pattern can be altered by modulating the signal pathways mediating epithelial-mesenchymal interactions in developing teeth...
  63. ncbi Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs
    Frederic Michon
    Institute of Biotechnology, Developmental Biology Program, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Dev Biol 340:355-68. 2010
    ..We show that the expression of RNAi pathway effectors is dynamic during tooth morphogenesis and differentiation of dental cells...
  64. pmc The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes
    E C Salido
    Howard Hughes Medical Institute, University of California School of Medicine, Harbor UCLA Medical Center, Torrance
    Am J Hum Genet 50:303-16. 1992
    ..extracellular matrix proteins of the dental enamel, are transiently but abundantly expressed by ameloblasts during tooth development...
  65. ncbi Tissue engineering of complex tooth structures on biodegradable polymer scaffolds
    C S Young
    Department of Cytokine Biology and Harvard Forsyth Department of Oral Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Dent Res 81:695-700. 2002
    b>Tooth loss due to periodontal disease, dental caries, trauma, or a variety of genetic disorders continues to affect most adults adversely at some time in their lives...
  66. pmc Yersinia pestis Orientalis in remains of ancient plague patients
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:332-3. 2007
    ..We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis. These data show that only Orientalis type caused the 3 plague pandemics...
  67. pmc Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine
    G T J Huang
    University of Maryland, College of Dental Surgery, Dental School, Department of Endodontics, Prosthodontics and Operative Dentistry, 650 West Baltimore St, Baltimore, MD 21201, USA
    J Dent Res 88:792-806. 2009
    ..Important issues in stem cell biology, such as stem cell niche, homing, and immunoregulation, will also be discussed...
  68. pmc Effects of gape and tooth position on bite force and skull stress in the dingo (Canis lupus dingo) using a 3-dimensional finite element approach
    Jason Bourke
    School of Biological Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 3:e2200. 2008
    Models of the mammalian jaw have predicted that bite force is intimately linked to jaw gape and to tooth position...
  69. ncbi Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis
    Mitsushiro Nakatomi
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Dev Biol 340:438-49. 2010
    ..and mice that are single homozygous mutant for either gene exhibit cleft palate and an early arrest of tooth formation...
  70. ncbi Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    Y Chai
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 127:1671-9. 2000
    ..we make use of a two-component genetic system for indelibly marking the progeny of the cranial neural crest during tooth and mandible development...
  71. ncbi Genetic basis of skin appendage development
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, P O Box 56 Viikinkaari 9, University of Helsinki, 00014 Helsinki, Finland
    Semin Cell Dev Biol 18:225-36. 2007
    ..After the bud stage, these organs adopt diverse patterns of epithelial growth, reflected in the usage of more divergent genes in each...
  72. ncbi Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
    Bmp4 is a downstream gene of Msx1 in early mouse tooth development...
  73. ncbi Dental microwear patterns of extant and extinct Muridae (Rodentia, Mammalia): ecological implications
    Helder Gomes Rodrigues
    Laboratoire de Paléontologie Paléobiologie Phylogénie, Institut des Sciences de l Evolution de l Université Montpellier II, UMR CNRS 5554 Case courrier 064, Place Eugene Bataillon, 34 095, Montpellier Cedex 5, France
    Naturwissenschaften 96:537-42. 2009
    ..These results concur with the presence of open to woodland areas covered by an herbaceous vegetal layer, including monocotyledons, in the vicinity of this mid-Pliocene locality...
  74. ncbi Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch and Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:5008-16. 2006
    In tooth development, the oral ectoderm and mesenchyme coordinately and reciprocally interact through the basement membrane for their growth and differentiation to form the proper shape and size of the tooth...
  75. ncbi Signalling networks regulating dental development
    I Thesleff
    Institute of Biotechnology, University of Helsinki, Finland
    Mech Dev 67:111-23. 1997
    There has been rapid progress recently in the identification of signalling pathways regulating tooth development...
  76. pmc Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development
    Il Hyuk Chung
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Stem Cells 27:866-77. 2009
    ..In addition, CNCCs support tooth germ survival via BMP signaling in our CNCC-tooth germ cotransplantation system...
  77. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
    Classical tissue recombination studies demonstrated that initiation of tooth development depends on activation of odontogenic potential in the mesenchyme by signals from the presumptive dental epithelium...
  78. ncbi TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation
    Borut Klopcic
    I Medical Department, Section Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Eur J Cell Biol 86:781-99. 2007
    ..This study shows that TGF-beta superfamily signaling is essential for development of hair, tooth and T-cells as well as differentiation and proliferation control in adult tissues.
  79. ncbi Dental topography and molar wear in Alouatta palliata from Costa Rica
    John C Dennis
    Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Am J Phys Anthropol 125:152-61. 2004
    ..Here we evaluate this assumption with a longitudinal study of changes in tooth form over time in primates...
  80. pmc New radiometric ages for the BH-1 hominin from Balanica (Serbia): implications for understanding the role of the Balkans in Middle Pleistocene human evolution
    William J Rink
    School of Geography and Earth Sciences, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 8:e54608. 2013
    ....
  81. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    ..We have examined the Tabby tooth phenotype in detail by analysis of the adult and embryonic teeth...
  82. ncbi The association of tooth scaling and decreased cardiovascular disease: a nationwide population-based study
    Zu Yin Chen
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Am J Med 125:568-75. 2012
    ..The aim of this study is to investigate the association between tooth scaling and the risk of cardiovascular events by using a nationwide, population-based study and a prospective ..
  83. ncbi The role of the dental lamina in mammalian tooth replacement
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, Finland
    J Exp Zool B Mol Dev Evol 312:281-91. 2009
    We have applied the ferret, Mustela putorius furo, as a model for tooth replacement. Ferret has a heterodont dentition, which includes all tooth families, and all antemolar teeth are replaced...
  84. pmc Extinction implications of a chenopod browse diet for a giant Pleistocene kangaroo
    Gavin J Prideaux
    School of Biological Sciences, Flinders University, Bedford Park, South Australia 5042, Australia
    Proc Natl Acad Sci U S A 106:11646-50. 2009
    ..Furthermore, oxygen isotope signatures of P. goliah tooth enamel show that it drank more in low-rainfall areas than its grazing contemporaries, similar to modern saltbush ..
  85. pmc Loss of teeth and enamel in tetrapods: fossil record, genetic data and morphological adaptations
    Tiphaine Davit-Beal
    Universite Pierre and Marie Curie, UMR, Paris, France
    J Anat 214:477-501. 2009
    ..published on the various living taxa concerned (and their extinct relatives) with the aim of tracing the origin of tooth or enamel loss, i.e...
  86. ncbi Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis
    Yael Gruenbaum-Cohen
    Dental Research Laboratory, Institute of Dental Sciences, Hebrew University, Hadassah, Faculty of Dental Medicine, Jerusalem, Israel
    J Exp Zool B Mol Dev Evol 312:445-57. 2009
    ..to have signaling activity; to produce ectopically chondrogenic and osteogenic-like tissue and to affect mouse tooth germ differentiation in vitro...
  87. ncbi From snout to beak: the loss of teeth in birds
    Antoine Louchart
    Institut de Génomique Fonctionnelle de Lyon, CNRS, UMR 5242, ENS de Lyon, Universite de Lyon, Universite Lyon 1, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    Trends Ecol Evol 26:663-73. 2011
    ..by far the most diverse toothless vertebrate clade, and are striking examples of evolutionary success following tooth loss...
  88. ncbi The taming of the shrew milk teeth
    Elina Järvinen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Evol Dev 10:477-86. 2008
    A characteristic feature of mammalian dentition is the evolutionary reduction of tooth number and replacement...
  89. ncbi The earliest known eutherian mammal
    Qiang Ji
    Chinese Academy of Geological Sciences, Beijing 100037, China
    Nature 416:816-22. 2002
    ..This suggests that the earliest eutherian lineages developed different locomotory adaptations, facilitating their spread to diverse niches in the Cretaceous...
  90. ncbi Was the Black Death caused by Yersinia pestis?
    Michael B Prentice
    Centre for Infection, Queen Mary s School of Medicine and Dentistry, London, UK
    Lancet Infect Dis 4:72. 2004
  91. ncbi Brief communication: co-detection of Bartonella quintana and Yersinia pestis in an 11th-15th burial site in Bondy, France
    Thi Nguyen Ny Tran
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS, IRD, IFR, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Am J Phys Anthropol 145:489-94. 2011
    ..These data suggest a plague epidemic in a population already infected by the body louse-transmitted B. quintana or a body louse-driven transmission of the plague that drove a medieval epidemic in inland Europe...
  92. ncbi Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis
    P Kettunen
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 211:256-68. 1998
    To elucidate the roles of fibroblast growth factors (FGF) in the regulation of tooth morphogenesis we have analyzed the expression patterns of Fgf-4, -8, and -9 in the developing mouse molar and incisor tooth germs from initiation to ..
  93. pmc The isotopic ecology of African mole rats informs hypotheses on the evolution of human diet
    Justin D Yeakel
    Department of Anthropology, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
    Proc Biol Sci 274:1723-30. 2007
    ..recovered from hominin-bearing deposits. These values overlap those reported for A. africanus and P. robustus and we conclude that the USO hypothesis for hominin diets retains certain plausibility...
  94. pmc Pseudogenization of the tooth gene enamelysin (MMP20) in the common ancestor of extant baleen whales
    Robert W Meredith
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Biol Sci 278:993-1002. 2011
    ..Adult mysticetes lack teeth, although tooth buds are present in foetal stages...
  95. ncbi Distribution of missing teeth and tooth morphology in patients with oligodontia
    Y Schalk van der Weide
    University of Utrecht
    ASDC J Dent Child 59:133-40. 1992
    ..Patients with oligodontia/S were missing significantly more teeth than patients with oligodontia/I...
  96. ncbi A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination
    Thimios A Mitsiadis
    Department of Orofacial Development and Structure, Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, Plattenstrasse 11, CH 8032 Zurich, Switzerland
    Dev Biol 320:39-48. 2008
    The Tbx1 gene is a transcriptional regulator involved in the DiGeorge syndrome, which affects normal facial and tooth development. Several clinical reports point to a common enamel defect in the teeth of patients with DiGeorge syndrome...
  97. ncbi Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth
    Hee Jae Cha
    Department of Parasitology and Genetics, College of Medicine, Kosin University, Busan, South Korea
    Int J Dev Biol 54:135-40. 2010
    ..We found that the expression of laminin-5 was up-regulated in the skin of the transgenic mice. We conclude that thymosin beta 4 has an important physiological role in hair growth and in tooth development.
  98. pmc SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis
    Jingyuan Li
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 138:1977-89. 2011
    TGFβ/BMP signaling regulates the fate of multipotential cranial neural crest (CNC) cells during tooth and jawbone formation as these cells differentiate into odontoblasts and osteoblasts, respectively...
  99. ncbi The effect of heritability on Bolton tooth-size discrepancy
    Bülent Baydaş
    Department of Orthodontics, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
    Eur J Orthod 27:98-102. 2005
    The purpose of this study was to determine the possible effect of genetic factors on Bolton tooth-size discrepancy. Subjects who applied for orthodontic treatment and their siblings (106 females and 78 males) were included in the study...
  100. ncbi Tissue interactions in the regulation of axon pathfinding during tooth morphogenesis
    Keijo Luukko
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Bergen, Norway
    Dev Dyn 234:482-8. 2005
    Like many other organs, the tooth develops as a result of the epithelial-mesenchymal interactions...
  101. ncbi Differential expression of multiple cell-surface heparan sulfate proteoglycans during embryonic tooth development
    X M Bai
    Center for Human Genetics, University of Leuven, Belgium
    J Histochem Cytochem 42:1043-54. 1994
    ..Taking tooth development in the mouse embryo as a model to further investigate the relevance of this PG redundancy and using ..

Research Grants78

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..afflicts over half of all American adults and can progress to periodontal disease, eventually resulting in tooth loss...
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..an inflammatory disease of the supporting tissues of the teeth leading to resorption of alveolar bone and eventual tooth loss...
  3. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dental caries (tooth decay) remains a significant national and international health problem, especially in low- income and disadvantaged populations...
  4. Genetics of the Neuromuscular Junction: Mechanisms and Disease Models
    Robert W Burgess; Fiscal Year: 2013
    ..Mutations in glycyl tRNA synthetase (GARS) and tyrosyl tRNA synthetase (YARS) cause Charcot-Marie-Tooth type D and Dominant Intermediate Charcot-Marie- Tooth type C (CMT2D and DI-CMTC) respectively...
  5. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic gingival inflammation of the soft tissue surrounding the tooth afflicts over half of all American adults...
  6. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    This application is designed to identify compounds to treat Charcot-Marie-Tooth type 2E (CMT2E). CMT is the most commonly inherited neurological disorder with a reported prevalence of 1 in 2,500 people worldwide...
  7. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
    ..This organism causes tooth decay because it generates acid from dietary carbohydrates and it survives because it can tolerate its own acid ..
  8. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tooth loss from periodontal disease or dental caries afflicts most adults over the course of their lives...
  9. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..Headache, back pain, arthritis pain, tooth pain, cancer pain, and post-operative pain are just a few of the common conditions contributing to decreased ..
  10. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011
    ..inherited diseases such as Leber's Hereditary Optic Neuropathy (LHON), Leigh's Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia...
  11. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..periodontitis) and causes tooth loss. These pathological changes can result from dysregulated production of reactive oxygen species...
  12. Click chemistry for novel antimicrobials against periodontal pathogens
    Valery V Fokin; Fiscal Year: 2010
    ..Advanced stages of the disease lead to bone resorption and diminished tooth attachment...
  13. In vivo analysis of the mechanisms of axon transport.
    Catherine M Drerup; Fiscal Year: 2011
    ..neurodegenerative disorders, including Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Charcot-Marie Tooth Disease...
  14. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2013
    ..Indeed, the association of NF gene mutations with Charcot Marie Tooth type 2E/1F neuronopathy and with early-onset Parkinson's disease (PD) unequivocally implicates NF directly in ..
  15. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    ..When transiently introduced into the bloodstream following daily dental hygienic practices such as tooth brushing and flossing, this bacterium can also cause potentially lethal endocarditis infections in atrisk patients...
  16. Transcriptional Regulation by a Deacetylase, CobB, in a Periodontopathogen
    DAVID J KOLODRUBETZ; Fiscal Year: 2013
    ..by applicant): Periodontitis is a disease of the subgingival crevice that leads to soft tissue degeneration and tooth loss...
  17. The role of IFT80 in bone formation
    Shuying Yang; Fiscal Year: 2013
    ..The long term objective of this work is to understand the functionmechanism and interactions of IFT/cilia proteins in bone development and bone diseases. ..
  18. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..alveolar bone loss, probing pocket depth, and clinical attachment loss, which have been measured on each tooth approximately every 3 years...
  19. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders that affects ~ 1 in 2,500 people in the US...
  20. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..may be sufficient to further destroy the tissues, including periodontal ligament and bone, which surrounds the tooth, creating a periodontal pocket...
  21. Bisphenol A and Children's Growth & Development
    KIM G contact HARLEY; Fiscal Year: 2010
    ....
  22. Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    Jean Wactawski Wende; Fiscal Year: 2010
    ..to standardized protocols to assess indices of oral and periodontal health (CAL, ACH, bleeding, plaque, calculus, tooth loss, DMFT, oral bone density)...
  23. Tousled kinase contributes to survival of salivary acinar cells against radiation
    Gulshan Sunavala-Dossabhoy; Fiscal Year: 2013
    ..It also contributes to the risk of oral infections, ulcerations, and rapid tooth decay...
  24. Reducing Care-Resistant Behaviors During Oral Hygiene in Persons with Dementia
    Rita A Jablonski; Fiscal Year: 2013
    ..This study will examine if a method for providing mouth care in a non-threatening way improves the oral health of nursing home residents with dementia. ..
  25. Function and regulation of Lhx genes in craniofacial development
    Juhee Jeong; Fiscal Year: 2010
    ..Based on my preliminary data, I will focus on the secondary palate and tooth development...
  26. Expression of clp genes in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2013
    ..The organism colonizes the oral cavity by forming diverse, multispecies biofilms on the tooth surface, known as dental plaque...
  27. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..applicant): Currently, very little is known regarding tissue-specific gene regulation during the later stages of tooth development, especially those associated with dentin mineralization...
  28. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..For our studies, we will test the efficacy of human VSELs to generate bone in humans in a tooth extraction model in which individuals requiring tooth extraction due to caries or periodontal disease will be the ..
  29. Stem Cell Based Therapy for Regenerative Endodontics
    George T J Huang; Fiscal Year: 2013
    ..the entire pulp poses two clinical problems: 1) further dental work such as crown and post that weaken the tooth are most often required;2) devitalized immature teeth are weak with little dentin structure...
  30. Bc12 regulates osteoclast survival
    Junro Yamashita; Fiscal Year: 2010
    ..An osteoporotic fracture can cause significant morbidity and mortality. Tooth loss due to periodontitis causes problems in mastication, pronunciation, and esthetics...
  31. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..obesity, genetic risk factors for pulmonary vascular disease and genetic regulation of craniofacial skeletal and tooth development and regeneration as well as a search for endogenous retroviruses in cancer tissue will depend on its ..
  32. New composite material design based on studies of tooth-composite and microbial i
    J Paul Santerre; Fiscal Year: 2013
    ..Objective: To study the degradation of resin-tooth interfacial margins with an in vitro simulated human oral system and teeth restored using clinical practice ..
  33. The Roles of FAM20C (DMP4) in Odontogenesis and Osteogenesis
    Chunlin Qin; Fiscal Year: 2013
    ....
  34. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..Aim #2 will investigate the hypothesis that the salivary gland generates functionally protective immunity to MCMV infection at both mucosal and systemic sites. ..
  35. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace A Spatafora; Fiscal Year: 2013
    ..In the present grant application, we profess a novel approach to alleviating tooth decay that is centered on investigating global virulence gene regulation by the S...
  36. Dietary patterns and root caries risk
    ELIZABETH A KAYE; Fiscal Year: 2010
    ..The findings may help to define healthy eating patterns that reduce the risk of root decay. ..
  37. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2013
    ..genes which are implicated in various other aspects of cranial development ranging from the initiation of tooth development to the growth and fusion of the secondary palate...
  38. East African Cichlids: A Natural Model for Dental Regeneration
    RYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013
    ..What we know about tooth development or odontogenesis has been almost exclusively derived from the mouse...
  39. Regulation of orofacial ectodermal polarity by the CLP protein, IRF6
    EMILY YIN CHU; Fiscal Year: 2013
    ..Specific aims were developed to investigate the contribution of IRF6 to primary palate and tooth development...
  40. Dental Caries: Whole Genome Association and Gene x Environment Studies
    Mary L Marazita; Fiscal Year: 2010
    Dental caries (also known as tooth decay) remains the most common chronic disease of childhood...
  41. RANKL and Inflammation-associated Bone Loss
    CHARLES A O'BRIEN; Fiscal Year: 2012
    ..inflammation-associated bone loss would also be relevant to other bone losing conditions such as periodontal tooth loss (the most common cause of adult loss of dentition), as well as the bone loss that occurs around prosthetic ..
  42. Manipulation of beta-catenin signaling in adult oral cells for tooth regeneration
    Sarah E Millar; Fiscal Year: 2010
    ..The ultimate goal of this project is to establish methods for bioengineering teeth from adult oral tissues. Tooth loss is a major health problem in the USA, experienced by up to 42% of the population in some states and ..
  43. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace Spatafora; Fiscal Year: 2009
    ..In the present grant application, we profess a novel approach to alleviating tooth decay that is centered on investigating global virulence gene regulation by the S...
  44. Bacterial peptidylarginine deiminase, a link between gums and joint disease
    JAN S POTEMPA; Fiscal Year: 2013
    ..This knowledge will create new perspectives in the treatment of periodontitis and prevention of rheumatoid arthritis in susceptible individuals. ..
  45. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2013
    ..The virulence of S. mutans resides in three core attributes;its abilities to adhere and form biofilms on tooth surfaces, to produce large quantities of organic acids from a wide range of carbohydrates, and to tolerate ..
  46. Assessing the Impact of Osteogenesis Imperfecta on Non-Skeletal Systems
    Laura Tosi; Fiscal Year: 2012
    ....
  47. Reversible phosphorylation in Hedgehog signaling
    ALAN ZHU; Fiscal Year: 2013
    ..abstract_text> ..
  48. Inositol Lipid regulation of membrane fusion and fission
    Lois S Weisman; Fiscal Year: 2013
    ..Moreover, selected mutations in Fig4 lead to a form of Charcot-Marie Tooth syndrome that is early onset and causes paraplegia/quadriplegia...
  49. Targeted delivery of osteoinductive molecules to biologic HA in bone grafts
    Jennifer L Bain; Fiscal Year: 2012
    ..regenerative procedures to restore alveolar bone that was lost from periodontal disease, trauma, or long-term tooth loss...
  50. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    ..Although centimeterscale information can be retained (for example, which tooth the plaque was taken from, or whether a sample was from the side or the top of the tongue), spatial information at ..
  51. Joubert Syndrome Biennial Conference: Advancing Translational Ciliopathy Research
    DANIEL A DOHERTY; Fiscal Year: 2013
    ..is a debilitating neurodevelopmental disorder characterized by a distinctive hindbrain malformation (the "molar tooth sign") combined with hypotonia, developmental delay, ataxia, and variable features such as cystic renal disease, ..
  52. Molecular Regulation of Human Dental Stem Cell Properties
    Cun Yu Wang; Fiscal Year: 2013
    ..Hence dental stem cells may present promising prospects for tooth regeneration and tissue repair...
  53. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    The study of the developmental regulation of tooth number and shape is important for understanding human disease...
  54. Establishment of Marmoset iPS-derived Cranial Neural Crest Cells
    Steven Farnsworth; Fiscal Year: 2013
    ..rise to cranial Schwann cells, peripheral neurons, facial bone, cartilage, and the dental mesenchyme required in tooth genesis...
  55. A Novel Approach for Biomaterials Assisted Regeneration of Pulp-Dentin Complex
    Satish Alapati; Fiscal Year: 2013
    ..will promote regeneration of dental pulp tissue and deposition of a reparative dentin barrier to maintain tooth vitality. The literature suggests that ~4 million root canal procedures are performed annually in the US...
  56. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dental caries, commonly known as tooth decay, is a serious health problem all over the world, and is one of the most common infectious diseases in humans...
  57. Daily Mouth Care to Prevent Pneumonia in Nursing Homes: A Systems-Level Approach
    Sheryl Zimmerman; Fiscal Year: 2013
    ..Almost 90% of residents require help with tooth brushing, yet only 16% have their teeth brushed regularly...
  58. A qualitative description of a pilot project to improve access to care in one Den
    SARAH ELAINE RASKIN; Fiscal Year: 2011
    ..Page 1 of 1 Qualitative description of a dental health pilot project ..
  59. Mechanisms of dental pulp stem cell differentiation into functional endothelium
    JACQUES EDUARDO NOR; Fiscal Year: 2013
    ..provided by applicant): The Problem: The dental pulp contains pluripotent stem cells that play a critical role in tooth development and tissue regeneration...
  60. The use of patient-specific iPS cells to identify osteoclast defects in CMD
    I Ping Chen; Fiscal Year: 2011
    ....
  61. Oral Health in Breast Cancer Survivors on Aromatase Inhibitors
    Linda Susan Taichman; Fiscal Year: 2013
    ..including assessment of mucosal lesions, periodontal measures, dental caries, oral x-rays, oral fluid, and tooth loss examination will be performed)...
  62. Northwest/Alaska/Hawaii Center to Reduce Oral Health Disparities
    PETER M MILGROM; Fiscal Year: 2012
    ..Center to Reduce Oral Health Disparities at the University of Washington in Seattle focuses on tooth decay in children, because it is the major oral health challenge U.S. society faces...
  63. BIOMECHANISMS OF TOOTH ERUPTION,RESORPTION & REPLACEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1993
    ..include eruption deviations in time and location, premature or delayed exfoliation of deciduous teeth, and tooth ankylosis...
  64. NON-INVASIVE HIGH-RESOLUTION DIAGNOSIS OF PERIODONTAL ATTACHMENT LEVELS USING REA
    SAM M MUKDADI; Fiscal Year: 2010
    ..Periodontal disease is clinically manifested by a degradation of the ligament that attaches the tooth to the bone...
  65. Subgingival Drug Delivery for Periodontitis Prevention and Treatment
    MARTYN DARBY; Fiscal Year: 2009
    In addition to the role oral infections play in promoting tooth loss, periodontitis has also been associated with increasing the risk of other medical conditions such as coronary artery disease, stroke and myocardial infarction...
  66. INDUCTION OF DE NOVO DENTAL PAPILLAE FROM YOUNG RODENT
    Mina Mina; Fiscal Year: 2001
    Adult teeth lack the ability to reconstruct and/or regenerate missing tissues. As a result tooth loss is currently being treated by a variety of traditional clinical therapies using prostheses and implants...
  67. Biofilm Architecture of Subgingival Plaque
    Renate Lux; Fiscal Year: 2009
    ..These chronic biofilm infections of the tooth-supporting tissues that are the major cause of tooth loss have also been associated with systemic diseases...
  68. ATYPICAL ODONTALGIA AND ENDODONTIC TREATMENT, SENSORY TESTING AND GENETIC STUDY
    Eli Eliav; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atypical odontalgia (AO), also known as phantom tooth pain and trigeminal deafferentation pain, is defined by the International Association for the Study of Pain as a severe throbbing pain in a tooth ..
  69. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Dental caries (tooth decay) is one of the most prevalent and costly infectious diseases in the United States...
  70. Bcl-2, A Key Factor for Dentinogenesis and Tooth Damage Repair
    Wenjian Zhang; Fiscal Year: 2010
    ..to anticipated outcomes, the work will demonstrate the role of odontoblast apoptosis in dentin formation and tooth damage repair...
  71. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    ..miniaturization of the two dimensional probe, so that dentist need only hold a probe in a fixed position against a tooth and obtain a complete three dimensional scan of the structure in less than one second...
  72. Coordinated bioengineering of tooth and bone in the jaw
    Pamela Yelick; Fiscal Year: 2005
    b>Tooth loss continues to plague many Americans, and is complicated by bone resorption in the jaw...
  73. CHEMICAL RELEASE & IMMUNE SENSITIZATION BY DENTAL RESINS
    Anahid Jewett; Fiscal Year: 2002
    ..Resin based materials which polymerize in the mouth are now used by dentists in many ways to help prevent tooth decay and for tooth repair and replacement...
  74. Clinical System for Measurement of Oral Crest Height Change in Dental Radiographs
    ALAN WALCZAK; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Alveolar bone height correlates well with subsequent tooth loss. In research settings, manual measurements of bone height from digitized images of radiographs have shown a precision of about 0...
  75. Cellular and Molecular Determinants of Tooth Eruption
    Hitesh Kapadia; Fiscal Year: 2005
    ..The doctoral research will focus on tooth eruption, a multifactorial process of key signaling interactions between osteoblasts, osteoclasts, and the dental ..
  76. GENETIC ANALYSIS OF THE MECHANISMS THAT REGULATE TOOTH MORPHOGENESIS
    GAIL ROBERTA MARTIN; Fiscal Year: 2010
    These studies are aimed at understanding the mechanisms that regulate tooth number and morphogenesis...
  77. TOOTH LOSS AND AGE RELATED HEARING LOSS
    Herenia Lawrence; Fiscal Year: 1999
    This study will evaluate a hypothetical association between tooth loss and age-related hearing loss in health male adults...
  78. Tooth Eruption: Role of Dental Follicle & PTH Receptor
    Laurie McCauley; Fiscal Year: 2006
    The process of tooth eruption is dependent on numerous events, cells and factors, many of which have been initially identified, but are as of yet poorly defined...