gingiva

Summary

Summary: Oral tissue surrounding and attached to TEETH.

Top Publications

  1. ncbi Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease
    Toshiaki Ara
    Department of Pharmacology, Matsumoto Dental University, Gobara, Hirooka, Shiojiri, Japan
    J Periodontal Res 44:21-7. 2009
  2. pmc Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis
    Qunzhou Zhang
    Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA 90033, USA
    J Immunol 183:7787-98. 2009
  3. pmc Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms
    G T Huang
    Section of Endodontics, Division of Oral Biology and Medicine and Orofacial Pain, UCLA School of Dentistry, Los Angeles, California 90095 1668, USA
    Infect Immun 69:1364-72. 2001
  4. ncbi Localized antimicrobial peptide expression in human gingiva
    B A Dale
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195 7132, USA
    J Periodontal Res 36:285-94. 2001
  5. ncbi Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats
    Kenjiro Nagamine
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pain 7:659-70. 2006
  6. ncbi Toll-like receptors and their role in periodontal health and disease
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    Periodontol 2000 43:41-55. 2007
  7. ncbi The gingival biotype revisited: transparency of the periodontal probe through the gingival margin as a method to discriminate thin from thick gingiva
    Tim De Rouck
    School of Dental Medicine, Free University of Brussels VUB, Brussels, Belgium
    J Clin Periodontol 36:428-33. 2009
  8. ncbi Molecular interaction of Porphyromonas gingivalis with host cells: implication for the microbial pathogenesis of periodontal disease
    Atsuo Amano
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 74:90-6. 2003
  9. ncbi Gingival and periodontal ligament fibroblasts differ in their inflammatory response to viable Porphyromonas gingivalis
    N Scheres
    Departments of Oral Microbiology, Oral Cell Biology and Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Research Institute MOVE, The Netherlands
    J Periodontal Res 45:262-70. 2010
  10. ncbi Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Crit Rev Oral Biol Med 13:132-42. 2002

Detail Information

Publications330 found, 100 shown here

  1. ncbi Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease
    Toshiaki Ara
    Department of Pharmacology, Matsumoto Dental University, Gobara, Hirooka, Shiojiri, Japan
    J Periodontal Res 44:21-7. 2009
    ....
  2. pmc Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis
    Qunzhou Zhang
    Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA 90033, USA
    J Immunol 183:7787-98. 2009
    ..In this study, we isolated a new population of stem cells from human gingiva, a tissue source easily accessible from the oral cavity, namely, gingiva-derived mesenchymal stem cells (GMSCs), ..
  3. pmc Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms
    G T Huang
    Section of Endodontics, Division of Oral Biology and Medicine and Orofacial Pain, UCLA School of Dentistry, Los Angeles, California 90095 1668, USA
    Infect Immun 69:1364-72. 2001
    ..gingivalis challenge alone. Thus, together with the protease effect, P. gingivalis possesses a powerful strategy to ensure the down-regulation of IL-8 and ICAM-1...
  4. ncbi Localized antimicrobial peptide expression in human gingiva
    B A Dale
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195 7132, USA
    J Periodontal Res 36:285-94. 2001
    ..These findings show that defensins and other antimicrobial peptides are localized in specific sites in the gingiva, are synthesized in different cell types, and are likely to serve different roles in various regions of the ..
  5. ncbi Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats
    Kenjiro Nagamine
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pain 7:659-70. 2006
    We developed a rat model of oral cancer pain by inoculating cancer cells into the lower gingiva. A squamous cell carcinoma (SCC) derived from Fisher rats, SCC-158, was inoculated into the subperiosteal tissue on the lateral side of the ..
  6. ncbi Toll-like receptors and their role in periodontal health and disease
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    Periodontol 2000 43:41-55. 2007
  7. ncbi The gingival biotype revisited: transparency of the periodontal probe through the gingival margin as a method to discriminate thin from thick gingiva
    Tim De Rouck
    School of Dental Medicine, Free University of Brussels VUB, Brussels, Belgium
    J Clin Periodontol 36:428-33. 2009
    ..To detect groups of subjects in a sample of 100 periodontally healthy volunteers with different combinations of morphometric data related to central maxillary incisors and surrounding soft tissues...
  8. ncbi Molecular interaction of Porphyromonas gingivalis with host cells: implication for the microbial pathogenesis of periodontal disease
    Atsuo Amano
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 74:90-6. 2003
    ..Collectively, these findings suggest that fimbriae of P. gingivalis, especially type II, are involved in the initiation and progression of human periodontitis...
  9. ncbi Gingival and periodontal ligament fibroblasts differ in their inflammatory response to viable Porphyromonas gingivalis
    N Scheres
    Departments of Oral Microbiology, Oral Cell Biology and Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Research Institute MOVE, The Netherlands
    J Periodontal Res 45:262-70. 2010
    ..This study aimed to investigate the effects of viable P. gingivalis on the expression of genes associated with inflammation and bone degradation by these fibroblast subsets...
  10. ncbi Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Crit Rev Oral Biol Med 13:132-42. 2002
    ..In this article, we review recent findings on the signaling pathways induced by the binding of P. gingivalis LPS to CD14 and Toll-like receptors (TLRs) in gingival fibroblasts...
  11. pmc Bacterial diversity in human subgingival plaque
    B J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Bacteriol 183:3770-83. 2001
    ..When organisms found on other oral surfaces such as the cheek, tongue, and teeth are added to this number, the best estimate of the total species diversity in the oral cavity is approximately 500 species, as previously proposed...
  12. ncbi Fusobacterium nucleatum enhances invasion of human gingival epithelial and aortic endothelial cells by Porphyromonas gingivalis
    Atsushi Saito
    Oral Health Science Center, Tokyo Dental College, Chiba, Japan
    FEMS Immunol Med Microbiol 54:349-55. 2008
    ..nucleatum facilitates invasion of host cells by P. gingivalis. Investigations of polymicrobial infection of host cells should improve our understanding of the role of P. gingivalis in periodontal infection and proatherogenic mechanisms...
  13. ncbi Differential modulation of human {beta}-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structures
    Qian Lu
    The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong
    Innate Immun 15:325-35. 2009
    ..gingivalis in periodontal pathogenesis...
  14. ncbi Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis
    Cristina Ribeiro Cardoso
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, Brazil
    J Leukoc Biol 84:311-8. 2008
    ..Finally, these results indicate that Tregs are found in the chronic lesions and must be involved in the modulation of local immune response in CP patients...
  15. ncbi On a path to unfolding the biological mechanisms of orthodontic tooth movement
    V Krishnan
    Department of Orthodontics, Rajas Dental College, Tirunelveli District, Tamilnadu, India
    J Dent Res 88:597-608. 2009
    ..If both are working in concert, orthodontists might be able to accelerate or decelerate tooth movement by adding adjuvant methods, whether physical, chemical, or surgical...
  16. ncbi The junctional epithelium around murine teeth differs from gingival epithelium in its basement membrane composition
    J Oksonen
    University of Turku, Institute of Dentistry, Finland
    J Dent Res 80:2093-7. 2001
    ..The exclusive expression of the non-self-polymerizing laminin-5 indicates that the IBL is not a BM by definition, but rather a simple extracellular matrix lacking network structure...
  17. ncbi Involvement of both mitochondrial- and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human gingival fibroblasts
    Jin Ha Lee
    Dental Science Research Institute, 2nd Stage of Brain Korea 21 for School of Dentistry, Chonnam National University, Gwang ju 500 757, South Korea
    Toxicology 243:340-7. 2008
    ..These results suggest that NaF induces apoptosis in HGF through both the mitochondria-mediated pathways regulated by the Bcl-2 family and death receptor-mediated pathway...
  18. pmc Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species
    Panagiota G Stathopoulou
    Center for Oral Health and Systemic Disease, University of Louisville School of Dentistry, University of Louisville, Louisville, KY, USA
    J Clin Periodontol 37:24-9. 2010
    ....
  19. ncbi Pattern of distribution of Prevotella species/phylotypes associated with healthy gingiva and periodontal disease
    M A Nadkarni
    Institute of Dental Research, Westmead Millennium Institute and Westmead Centre for Oral Health, Westmead, NSW, Australia
    Eur J Clin Microbiol Infect Dis 31:2989-99. 2012
    ..This study provides a comprehensive analysis of Prevotella species associated with gingival sites for the informative evaluation of the epidemiology of infection by this genus...
  20. ncbi Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors
    G S Thangjam
    Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore, India
    J Periodontal Res 44:736-43. 2009
    ..The basic aim of our study was to elucidate the mechanism underlying the action of arecoline on the expression of genes in oral fibroblasts...
  21. pmc Microbiology of odontogenic bacteremia: beyond endocarditis
    N B Parahitiyawa
    Faculty of Dentistry, Oral Bio Sciences, The University of Hong Kong, Hong Kong SAR
    Clin Microbiol Rev 22:46-64, Table of Contents. 2009
    ..The nature of the infective agents and end organ infections (other than endocarditis) is also described, with an emphasis on the challenge of establishing the link between odontogenic infections and related systemic, focal infections...
  22. ncbi Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts
    Thanuja D K Herath
    Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
    J Clin Periodontol 38:694-701. 2011
    ..This study investigated the effects of the two isoforms of P. gingivalis LPS on the expression of IL-6, IL-8 and TNF-α in human gingival fibroblasts (HGFs)...
  23. ncbi Expression of bone associated macromolecules by gingival and periodontal ligament fibroblasts
    S Ivanovski
    Department of Dentistry, University of Queensland, Brisbane, Australia
    J Periodontal Res 36:131-41. 2001
    ..BM P-4 within sections of human periodontal structures was stronger in the periodontal ligament compared to the gingiva. Bone sialoprotein was not detected in either of the soft tissues but, along with osteopontin and osteocalcin, it ..
  24. pmc The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay
    Ozlem Yilmaz
    Department of Periodontology, College of Dentistry and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
    Microbiology 154:2897-903. 2008
    ..These new findings may also represent an original and valuable model for mechanistic characterization of other successful host-adapted, self-limiting, persistent intracellular bacteria in human epithelial tissues...
  25. ncbi Effect of transforming growth factor-beta1, interleukin-6, and interferon-gamma on the expression of type I collagen, heat shock protein 47, matrix metalloproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis
    H Martelli-Junior
    Discipline of Oral Pathology, University of Campinas Dental School, Piracicaba, Sao Paulo, Brazil
    J Periodontol 74:296-306. 2003
    Increased collagen and extracellular matrix deposition within the gingiva is the main characteristic feature of hereditary gingival fibromatosis (HGF)...
  26. pmc The host cytokine response to Porphyromonas gingivalis is modified by gingipains
    P G Stathopoulou
    Department of Periodontics, University of Louisville School of Dentistry, Louisville, KY 40202, USA
    Oral Microbiol Immunol 24:11-7. 2009
    ..In the present study, we sought to determine how P. gingivalis influences the inflammatory cytokine responses...
  27. ncbi Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites
    Ebru Urcan
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstrasse 26, D 80336 Munich, Germany
    Biomaterials 31:2010-4. 2010
    ..25 and 0.5gamma-H2AX foci/HGF cell. Our results for the first time show that exposure to dental resin monomers can induce DSBs in primary human oral cavity cells, which underscores their genotoxic capacity...
  28. ncbi Protease-activated receptor signaling increases epithelial antimicrobial peptide expression
    Whasun O Chung
    Department of Oral Biology, University of Washington, Seattle 98195 7132, USA
    J Immunol 173:5165-70. 2004
    ..Thus, P. gingivalis proteases are directly involved in regulation of hBD-2 in cultured GEC, and this induction partially uses the PAR-2 receptor and signaling pathway...
  29. pmc Antimicrobial peptides in the oral environment: expression and function in health and disease
    Beverly A Dale
    Dept of Oral Biology, Box 357132, University of Washington, Seattle, WA 98195 7132, USA
    Curr Issues Mol Biol 7:119-33. 2005
    ..This may have major significance for understanding host defense in the complex oral environment...
  30. ncbi Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2
    Yutaka Kusumoto
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 75:370-9. 2004
    ..In order to investigate the possible activation of HGEC by Pg through Toll-like receptors (TLRs), we analyzed the production of chemotactic factors and the activated nuclear factor-kappa B (NF-kappaB)...
  31. pmc Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment
    J C Fenno
    Department of Microbiology, University of British Columbia, Vancouver, Canada
    Infect Immun 68:1884-92. 2000
    ..Binding of soluble host proteins by OppA may be important both for spirochete-host interactions in the subgingival environment and for uptake of peptide nutrients...
  32. pmc Expression profile of human gingival fibroblasts induced by interleukin-1beta reveals central role of nuclear factor-kappa B in stabilizing human gingival fibroblasts during inflammation
    Saynur Vardar-Sengul
    Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA
    J Periodontol 80:833-49. 2009
    ....
  33. ncbi The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome
    Marcela Claudino
    Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Leukoc Biol 84:1565-73. 2008
    ....
  34. pmc Human oral mucosa and gingiva: a unique reservoir for mesenchymal stem cells
    Q Z Zhang
    Department of Oral and Maxillofacial Surgery and Pharmacology, Penn Dental Medicine and Penn Medicine Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Dent Res 91:1011-8. 2012
    ..experimental studies on the characterization of a unique population of MSCs derived from human oral mucosa and gingiva, especially their immunomodulatory and anti-inflammatory functions and their application in the treatment of ..
  35. pmc Molecular analysis of the subgingival microbiota in health and disease
    Ruth G Ledder
    School of Pharmacy and Pharmaceutical Sciences, Coupland III Building, University of Manchester, Manchester M13 9PL, United Kingdom
    Appl Environ Microbiol 73:516-23. 2007
    ..was a significant predictor of disease (P < 0.05) and that there was no significant difference (P > 0.05) in terms of eubacterial species diversity between health and disease...
  36. pmc ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis
    Ozlem Yilmaz
    Department of Periodontology, University of Florida, Gainesville, FL 32610, USA
    Cell Microbiol 12:188-98. 2010
    ..The Nalp3 inflammasome is therefore likely to be an important mediator of the inflammatory response in gingival epithelium...
  37. ncbi The distribution and expression of S100A8 and S100A9 in gingival epithelium of mice
    K Nishii
    Department of Periodontology, Showa University School of Dentistry, Ohta ku, Tokyo, Japan
    J Periodontal Res 48:235-42. 2013
    ..The aim of this study was to investigate the distribution of S100A8 and S100A9 expression in gingival epithelium of mice in the presence and absence of infection...
  38. pmc Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo
    C Sima
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    J Periodontal Res 45:748-56. 2010
    ..However, the cellular and molecular mechanisms linking the two conditions are not clear. The impact of chronic hyperglycemia on leukocyte margination and macromolecule extravasation was determined in gingival vessels in vivo...
  39. ncbi Treponema denticola lipooligosaccharide activates gingival fibroblasts and upregulates inflammatory mediator production
    Shin ichi Tanabe
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec, Canada
    J Cell Physiol 216:727-31. 2008
    ..denticola LOS. In summary, T. denticola LOS induced an inflammatory response in gingival fibroblasts and may thus contribute to the immunopathogenesis of periodontitis and the progression of the disease...
  40. ncbi Stromal myofibroblasts in focal reactive overgrowths of the gingiva
    Leonardo Silveira Damasceno
    Department of Dentistry, Pontificia Universidade Catolica de Minas Gerais, Belo Horizonte, MG, Brazil
    Braz Oral Res 26:373-7. 2012
    Focal reactive overgrowths are among the most common oral mucosal lesions. The gingiva is a significant site affected by these lesions, when triggered by chronic inflammation in response to microorganisms in dental plaque...
  41. ncbi Localization of bromodeoxyuridine-incorporating, p63- and p75(NGFR)- expressing cells in the human gingival epithelium
    Setsuko Hatakeyama
    Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan
    J Oral Sci 49:287-91. 2007
    ..These areas probably exhibit high proliferative activity owing to the presence of stem cells...
  42. pmc Characterization of the autocrine/paracrine function of vitamin D in human gingival fibroblasts and periodontal ligament cells
    Kaining Liu
    Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China
    PLoS ONE 7:e39878. 2012
    ....
  43. pmc Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kappaB ligand (RANKL+) T cells in bone resorption lesion of periodontal disease
    C W O Ernst
    Department of Immunology, The Forsyth Institute, Boston, MA 02115, USA
    Clin Exp Immunol 148:271-80. 2007
    ..This leads to the conclusion that the phenomenon of diminished CD25+FoxP3+ T(reg) cells appears to be associated with the increased RANKL+ T cells in the bone resorption lesion of periodontal disease...
  44. ncbi Epithelial antimicrobial peptides: review and significance for oral applications
    A Weinberg
    Department of Periodontics, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Crit Rev Oral Biol Med 9:399-414. 1998
    ..antimicrobial peptide, designated LL-37 and found in human neutrophils, is also expressed in skin and gingiva. It is highly likely that these and/or other epithelial antimicrobial peptides play an important role in ..
  45. ncbi Expression of defensins in gingiva and their role in periodontal health and disease
    W O Chung
    Department of Oral Biology, University of Washington, Seattle, WA 98195 7132, USA
    Curr Pharm Des 13:3073-83. 2007
    ..Present studies have identified specific signaling routes that pathogens and commensals take in stimulating these innate immune responses, and this may open the way for development of new therapeutic agents for periodontal diseases...
  46. pmc Vitamin D-mediated induction of innate immunity in gingival epithelial cells
    Laura McMahon
    Department of Oral Biology, UMDNJ New Jersey Dental School, Newark, NJ 07101, USA
    Infect Immun 79:2250-6. 2011
    ..This study is the first to demonstrate the effect of vitamin D on antibacterial defense of oral epithelial cells, suggesting that vitamin D(3) could be utilized to enhance the innate immune defense in the oral cavity...
  47. ncbi Real-time polymerase chain reaction quantification of human cytomegalovirus and Epstein-Barr virus in periodontal pockets and the adjacent gingiva of periodontitis lesions
    Ayhan Kubar
    Department of Virology, Gulhane Military Medical Academy, Ankara, Turkey
    J Periodontal Res 40:97-104. 2005
    ..This study determined levels of HCMV and EBV DNA in the periodontal pocket and in the adjacent gingiva of periodontitis lesions using a real-time polymerase chain reaction (PCR) assay.
  48. pmc Comparison of quaternary ammonium-containing with nano-silver-containing adhesive in antibacterial properties and cytotoxicity
    Fang Li
    Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
    Dent Mater 29:450-61. 2013
    ..long-distance inhibition, glucosyltransferases (gtf) gene expressions, and cytotoxicity for the first time...
  49. ncbi Expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy and diseased human gingiva
    Anne Laure Ejeil
    Department of Non Mineralized Tissue Physiopathology, Faculty of Dental Surgery, Universite Rene Descartes Paris V, Montrouge, France godeau
    J Periodontol 74:188-95. 2003
    ....
  50. ncbi Fusobacterium nucleatum enters normal human oral fibroblasts in vitro
    Gabriela Dabija-Wolter
    Faculty of Medicine and Dentistry, The Gade Institute, University of Bergen, Bergen, Norway
    J Periodontol 80:1174-83. 2009
    ..nucleatum (F. nucleatum ssp. nucleatum, F. nucleatum ssp. polymorphum, and F. nucleatum ssp. vincentii) to enter gingival fibroblasts (GFs) and periodontal ligament fibroblasts (PLFs)...
  51. pmc Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis
    Daniel Grenier
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec, Canada
    Infect Immun 71:4742-8. 2003
    ..gingivalis, including controlling the expression and/or processing of virulence factors. Mutations in gingipain genes thus give rise to pleiotropic effects...
  52. ncbi Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine
    Geetanjali B Tomar
    National Center for Cell Science, University of Pune Campus, Pune 411007, India
    Biochem Biophys Res Commun 393:377-83. 2010
    ..Thus, we reveal that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCs can ..
  53. ncbi Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis
    Daisuke Ekuni
    Department of Oral Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Arch Oral Biol 53:324-9. 2008
    ..We examined the effects of mechanical stimulation on the plasma 8-hydroxydeoxyguanosine level in a rat periodontitis model...
  54. ncbi Dynamic smile analysis: changes with age
    Shyam Desai
    Department of Craniofacial Sciences, Health Center, University of Connecticut, Farmington, CT 06030 1725, USA
    Am J Orthod Dentofacial Orthop 136:310.e1-10; discussion 310-1. 2009
    ..A secondary objective was to study the perioral changes from rest to smile and compare them on the basis of age...
  55. pmc Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts
    Tove Båge
    Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
    BMC Genomics 11:241. 2010
    ....
  56. ncbi Prostaglandin E2 regulates interleukin-1beta-induced matrix metalloproteinase-3 production in human gingival fibroblasts
    S M P M Ruwanpura
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Dent Res 83:260-5. 2004
    ..In HGF from healthy gingiva, PGE2 down-regulated IL-1beta-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced ..
  57. ncbi Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: a study utilizing immunohistochemistry and RT-PCR
    J Katz
    Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida, Gainesville, FL 32610 0416, USA
    J Clin Periodontol 32:40-4. 2005
    ..In this study we demonstrate the presence of RAGE in human periodontium in patients with chronic periodontitis with and without type 2 diabetes...
  58. ncbi A multicenter interracial study of facial appearance. Part 2: A comparison of intraoral parameters
    Edward G Owens
    School of Dentistry, Loma Linda University, Loma Linda, California 92350, USA
    Int J Prosthodont 15:283-8. 2002
    ..This article compares interracial or gender differences of six intraoral dental parameters among six racial groups (African American, Caucasian, Chinese, Hispanic, Japanese, and Korean)...
  59. ncbi Transglutaminase-2 regulation by arecoline in gingival fibroblasts
    G S Thangjam
    Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore 560012, India
    J Dent Res 88:170-5. 2009
    ..Our study provides evidence for TGM-2 overexpression in OSMF and its regulation by arecoline in oral fibroblasts...
  60. ncbi Whole cigarette smoke promotes human gingival epithelial cell apoptosis and inhibits cell repair processes
    A Semlali
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec, QC, Canada
    J Periodontal Res 46:533-41. 2011
    ....
  61. ncbi Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading
    Tae Yeon Lee
    Department of Orthodontics, College of Dentistry, Yonsei University, Seoul, South Korea
    Angle Orthod 79:733-9. 2009
    ..To test the hypothesis that orthodontic pressure does not induce gene transcription of IL-1beta, MMP-9, and TIMP-1 in pressure gingival soft tissue...
  62. ncbi Antimicrobial decapeptide KSL-W attenuates Candida albicans virulence by modulating its effects on Toll-like receptor, human β-defensin, and cytokine expression by engineered human oral mucosa
    A Semlali
    Oral Ecology Research Group, Faculty of Dentistry, Laval University, Quebec, QC, Canada
    Peptides 32:859-67. 2011
    ..This study proposes the potential application of KSL-W peptide as an alternative antifungal agent...
  63. ncbi Update on bacteraemia related to dental procedures
    Ingar Olsen
    Institute of Oral Biology, Faculty of Dentistry, University of Oslo, PB 1052 Blindern, 0316 Oslo, Norway
    Transfus Apher Sci 39:173-8. 2008
    ..It may be that patients never seeing a dentist are more unfitted as blood donors than those recently having seen one...
  64. ncbi Culturing primary human gingival epithelial cells: comparison of two isolation techniques
    U Kedjarune
    Department of Oral Biology and Occlusion Faculty of Dentistry, Prince of Songkla University, Hat Yai, Thailand
    J Craniomaxillofac Surg 29:224-31. 2001
    ..Little work has been done comparing these two techniques and their capacity to isolate and cultivate oral keratinocytes...
  65. ncbi Thickness of gingiva in association with age, gender and dental arch location
    K L Vandana
    Department of Periodontics, College of Dental Sciences, Davangere 577 044, Karnataka, India
    J Clin Periodontol 32:828-30. 2005
    ..Many features are genetically determined; others seem to be influenced by tooth size, shape and position and biological phenomena such as gender, growth and age...
  66. ncbi Management of inter-dental/inter-implant papilla
    Laura Zetu
    Department of Peridontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    J Clin Periodontol 32:831-9. 2005
    ....
  67. ncbi The effects of human mast-cell products and of phenytoin on androgen 5alpha-reductase expression in human gingival fibroblasts
    M Soory
    Division of Periodontology, Guy s King s and St Thomas Dental Institute, King s Campus, Caldecot Road, SE5 9RW, London, UK
    Arch Oral Biol 46:847-55. 2001
    ..The findings suggest a novel hypothesis that mast-cell mediated androgen action in the gingiva in response to phenytoin could contribute to gingival overgrowth.
  68. ncbi IGF-1 signaling enhances cell survival in periodontal ligament fibroblasts vs. gingival fibroblasts
    X Han
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, W 201E, Boston, MA, 02118, USA
    J Dent Res 82:454-9. 2003
    ..Analysis of the present data suggests an enhanced cell survival in PDLF compared with GF by the up-regulation of IGF-1 signaling pathway...
  69. ncbi ALK5 inhibition blocks TGFß-induced CCN2 expression in gingival fibroblasts
    K Thompson
    Division of Oral Biology, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, ON, Canada
    J Dent Res 89:1450-4. 2010
    ..These results suggest that blocking ALK5 may be useful in blocking the profibrotic effects of TGFβ in gingival fibroblasts...
  70. ncbi Vascular endothelial growth factor expression levels of gingiva in gingivitis and periodontitis patients with/without diabetes mellitus
    Gonca Cayir Keles
    Department of Periodontology, Ondokuzmayis University, Samsun, Turkey
    Inflamm Res 59:543-9. 2010
    ....
  71. ncbi Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms
    Wen Ru Su
    Center for Craniofacial Molecular Biology, The Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California 90, 033, USA
    Stem Cells 29:1849-60. 2011
    ..Here, we report a new immunological approach using human gingiva-derived MSCs (GMSCs) to desensitize and suppress CHS and the underlying mechanisms...
  72. ncbi Functional TLRs and NODs in human gingival fibroblasts
    A Uehara
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Dent Res 86:249-54. 2007
    ..These findings indicate that these innate immunity-related molecules in gingival fibroblasts are functional receptors involved in inflammatory reactions in periodontal tissues, which might be responsible for periodontal pathogenesis...
  73. ncbi Superoxide dismutase activity in gingiva in type-2 diabetes mellitus patients with chronic periodontitis
    Ferda Alev Akalin
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey
    Arch Oral Biol 53:44-52. 2008
    ..This study investigates antioxidant enzyme; superoxide dismutase (SOD) activity in gingiva and blood glucose and lipid levels in type-2 DM patients and systemically healthy individuals with chronic ..
  74. pmc Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo
    M R Guimaraes
    Department of Diagnosis and Surgery, Faculdade de Odontologia de Araraquara Univ Estadual Paulista UNESP, Araraquara, SP, Brazil
    J Periodontal Res 46:269-79. 2011
    ..Its therapeutic applications have been studied in a variety of conditions, including rheumatoid arthritis, colon cancer and depression, but no studies have evaluated the effects of curcumin on periodontal disease in vivo...
  75. ncbi Attachment and growth behaviour of human gingival fibroblasts on titanium and zirconia ceramic surfaces
    Ahran Pae
    Department of Prosthodontics, School of Dentistry, Kyung Hee University, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 701, Korea
    Biomed Mater 4:025005. 2009
    ..A zirconia ceramic surface with grooves showed biological responses that were comparable to those obtained with HGF on a titanium surface...
  76. ncbi Composition of supra- and subgingival biofilm of subjects with healthy and diseased implants
    Jamil A Shibli
    Department of Periodontology, Dental Research Division, Guarulhos University, Sao Paulo, Brazil
    Clin Oral Implants Res 19:975-82. 2008
    ..The purpose of this study was to compare the microbial composition of supra- and subgingival biofilm in subjects with and without peri-implantitis...
  77. pmc Human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis
    Tomoko Kurita-Ochiai
    Department of Microbiology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271 8587, Japan
    Infect Immun 70:2361-7. 2002
    ..These results suggest that the proinflammatory cytokines such as IL-6 and IL-11, produced in fibroblasts stimulated with butyric acid, are involved in the attenuation of T-cell apoptosis by gingival fibroblasts...
  78. pmc Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts
    A Kamemoto
    Department of Pharmacology, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri, Nagano 399 0781, Japan
    Eur J Med Res 14:309-14. 2009
    ....
  79. ncbi Expression of beta-defensins in gingival health and in periodontal disease
    John Bissell
    Dows Institute for Dental Research, Department of Periodontics, College of Dentistry, University of Iowa, IA 52242, USA
    J Oral Pathol Med 33:278-85. 2004
    ..The expression of three HBDs (HBD-1, HBD-2, and HBD-3) has been reported in oral mucosa, gingiva, and salivary glands. However, their role in protection against oral infections is not well understood...
  80. ncbi bFGF-loaded HA-chitosan: a promising scaffold for periodontal tissue engineering
    Abdullah C Akman
    Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sihhiye, Ankara, Turkey
    J Biomed Mater Res A 92:953-62. 2010
    ..The results demonstrated that bFGF-loaded HA-chitosan scaffolds provide a suitable three-dimensional environment supporting the cellular structure, proliferation, and mineralization...
  81. pmc Interplay of protease-activated receptors and NOD pattern recognition receptors in epithelial innate immune responses to bacteria
    Whasun O Chung
    Department of Oral Biology, University of Washington, Seattle, WA 98195 7132, USA
    Immunol Lett 131:113-9. 2010
    ....
  82. ncbi Fabrication of cultured oral gingiva by tissue engineering techniques without materials of animal origin
    Kazuto Yamada
    Department of Research and Development, Japan Tissue Engineering, Aichi, Japan
    J Periodontol 77:672-7. 2006
    ..To eliminate this risk, we designed new gingival substitutes made of recombinant human collagen types I and III sponges and cultured these substitutes in animal-free media (HFDM-1)...
  83. pmc Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis
    A Kantarci
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 700 Albany Street, Boston, MA 02118, USA
    J Pathol 210:59-66. 2006
    ..These findings suggest that interactions between epithelial and connective tissues could contribute to gingival fibrosis...
  84. ncbi Culture of human gingival fibroblasts on a biodegradable scaffold and evaluation of its effect on attached gingiva: a randomized, controlled pilot study
    Mohammad Mohammadi
    National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
    J Periodontol 78:1897-903. 2007
    An adequate width of attached gingiva is necessary to maintain healthy periodontium, especially in orthodontics or restorative treatments in periodontics...
  85. ncbi Surgical treatment of melanin-pigmented gingiva; an esthetic approach
    Khalid Almas
    Div Periodontics, Dept Preventive Dental Sciences, Dept Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh 11545, P O Box 60169, Kingdom of Saudi Arabi khalid
    Indian J Dent Res 13:70-3. 2002
    The aim of this clinical article is to review the methods of depigmentation of melanin pigmentation of gingiva and explain scalpel surgical technique for depigmentation of gingiva.
  86. ncbi Microbial comparison of smoker and non-smoker adult and early-onset periodontitis patients by polymerase chain reaction
    I B Darby
    Periodontal and Oral Immunology Research Group, Glasgow Dental Hospital and School, Scotland, UK
    J Clin Periodontol 27:417-24. 2000
    ..Our findings do not support the hypothesis that smokers have significant differences in the prevalence of periodontal pathogens from non-smokers...
  87. pmc Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells
    L Yao
    Department of Periodontology and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
    Mol Oral Microbiol 25:89-101. 2010
    ..gingivalis. The P. gingivalis uses other mitochondrial pathways to protect host cells from cell-death and to ensure its survival in gingival epithelium...
  88. pmc Protease-activated receptor 2 mediates human beta-defensin 2 and CC chemokine ligand 20 mRNA expression in response to proteases secreted by Porphyromonas gingivalis
    Henrik Dommisch
    Department of Oral Biology, School of Dentistry, University of Washington, Box 357132, Seattle, WA 98195 7132, USA
    Infect Immun 75:4326-33. 2007
    ..GECs use PARs to recognize P. gingivalis and mediate cell responses involved in innate immunity...
  89. pmc ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis
    Ozlem Yilmaz
    Department of Periodontology, University of Florida, Gainesville, FL 32610, USA
    Cell Microbiol 10:863-75. 2008
    ..Therefore, NDK promotes survival of host cells by hydrolysing extracellular ATP and preventing apoptosis-mediated through P2X(7)...
  90. ncbi Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects
    A D Haffajee
    Department of Periodontology, Forsyth Dental Center, Boston, MA, USA
    J Clin Periodontol 25:346-53. 1998
    ..01). Similar differences among subject groups were observed when only sites with PD 0-4 mm were analyzed. The data suggest an etiologic role for B. forsythus, P. gingivalis, T. denticola and S. noxia in adult periodontitis...
  91. ncbi NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter
    Ruth C Borghaei
    Department of Biochemistry and Molecular Biology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    Biochem Biophys Res Commun 316:182-8. 2004
    ..These results are consistent with a role for NF-kappaB in limiting the cytokine induced expression of MMP-3...
  92. pmc The capsule of Porphyromonas gingivalis reduces the immune response of human gingival fibroblasts
    Jorg Brunner
    Department of Oral Microbiology, Academic Centre for Dentistry Amsterdam, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
    BMC Microbiol 10:5. 2010
    ..One of the virulence factors of P. gingivalis is capsular polysaccharide (CPS). Non-encapsulated strains have been shown to be less virulent in mouse models than encapsulated strains...
  93. ncbi Gingival epithelial cell signalling and cytoskeletal responses to Porphyromonas gingivalis invasion
    Ozlem Yilmaz
    Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Microbiology 149:2417-26. 2003
    ..gingivalis. The results show that fimbriated P. gingivalis cells induce formation of integrin-associated focal adhesions with subsequent remodelling of the actin and tubulin cytoskeleton...
  94. ncbi The novel human beta-defensin-3 is widely expressed in oral tissues
    Anton Dunsche
    Department of Oral and Maxillofacial Surgery, University Hospital Kiel, Germany
    Eur J Oral Sci 110:121-4. 2002
    ..The results indicate an important role for the novel hBD-3, as well as for hBD-1 and hBD-2, in the innate oral epithelial host defense...
  95. ncbi Expression pattern of adhesion molecules in junctional epithelium differs from that in other gingival epithelia
    S Hatakeyama
    Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan
    J Periodontal Res 41:322-8. 2006
    ..Hence, the aim of the present study was to characterize the cell adhesion structure in the junctional epithelium compared with the other two epithelia...
  96. pmc Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing
    Qun zhou Zhang
    Center for Craniofacial Molecular Biology, The Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California 90033, USA
    Stem Cells 28:1856-68. 2010
    ..Recently, we have isolated a unique population of MSCs from human gingiva (GMSCs) with similar stem cell-like properties, immunosuppressive, and anti-inflammatory functions as human bone ..
  97. ncbi In or out: the invasiveness of oral bacteria
    Richard J Lamont
    Periodontol 2000 30:61-9. 2002
  98. pmc Role of Porphyromonas gingivalis SerB in gingival epithelial cell cytoskeletal remodeling and cytokine production
    Yoshiaki Hasegawa
    Department of Oral Biology and Center for Molecular Microbiology, College of Dentistry, University of Florida, Gainesville, FL 32610 0424, USA
    Infect Immun 76:2420-7. 2008
    ..SerB is thus capable of modulating host cell signal transduction that impacts the actin cytoskeleton and cytokine production...
  99. ncbi DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues
    Pao Li Wang
    Department of Pharmacology, Matsumoto Dental University, 1780 Gobara Hirooka Shiojiri 399 0781, Japan
    Biochem Biophys Res Commun 305:970-3. 2003
    ..CD14, TLR2, and TLR4 in human gingival fibroblasts (HGFs) obtained from patients with healthy or inflammatory gingiva using DNA microarray analysis...
  100. ncbi Regulation of prostaglandin E synthases: effects of siRNA-mediated inhibition of microsomal prostaglandin E synthase-1
    Tove Båge
    Department of Pediatric Dentistry, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden
    Biochim Biophys Acta 1773:1589-98. 2007
    ..Moreover, mPGES-1 siRNA did not affect PGE2 levels, whereas PGF(2alpha) increased, suggesting a compensatory pathway of PGE2 synthesis when mPGES-1 is knocked down...
  101. ncbi Microbiota of health, gingivitis, and initial periodontitis
    A Tanner
    Forsyth Dental Center, Boston, Massachusetts 02115, USA
    J Clin Periodontol 25:85-98. 1998
    ..The differences in location and microbiota of interproximal and buccal active sites suggested that different mechanisms may be involved in increased attachment loss...

Research Grants62

  1. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..work for more targeted control of ROS production as related to molecular pathways of host cell activation in the gingiva, and osteoimmunologic linkages that result in alveolar bone resorption...
  2. Neutrophil and Dendritic Cell Interactions
    Elizabeth Scisci; Fiscal Year: 2013
    ..Polymorphonuclear leukocytes (PMNs) act as 'first-responders'to microbial infections in the human gingiva. Microbial clearance by PMNs, however, is inhibited by the plaque biofilm...
  3. P. gingivalis-specific T cells in mice prone and resistant to periodontitis
    Massimo Costalonga; Fiscal Year: 2013
    ..Concurrently, we will define the nature and timing of inflammatory cell infiltrate in the marginal gingiva. Second, we will identify the direct effect of R/Kgp- specific effector Th cells on bone levels using a series of ..
  4. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION
    Yufang Shi; Fiscal Year: 2013
    ..Based on these observations, we explore the feasibility of isolating MSCs from human gingiva (hGMSCs), a unique oral tissue that functions both as a biological mucosal barrier and a component of the oral ..
  5. Vitamin D induction of antibacterial activity in gingival cells
    Gill Diamond; Fiscal Year: 2009
    ..Identification of a non- toxic agent that could increase antibacterial capabilities of the gingiva through transcriptional mechanisms could have long-reaching implications in the study of periodontal disease and ..
  6. Improved manufacture of bone transport plates
    TIMOTHY MULONE; Fiscal Year: 2009
    ..Reconstruction of the lower jaw typically involves bone, gingiva, and teeth...
  7. Study of Actinbacillus Actinomycetemcomitans Virulence
    Joseph M DiRienzo; Fiscal Year: 2012
    ..In the context of colonization and pathogenesis the protective epithelial cell layer that lines the gingiva is the principal target for the Cdt...
  8. Functional Tooth Mobility
    Zi Jun Liu; Fiscal Year: 2013
    ..Tooth mobility is determined structurally by periodontal tissues (ligament, gingiva, extracellular matrix and attachments to cementum and bone) and functionally by occlusal and muscular forces, and ..
  9. Blocking of IL-6 function to prevent Pg mediated Th17 response
    JAN S POTEMPA; Fiscal Year: 2013
    ..have shown elevated levels of IL-17, signature cytokine of Th17 cells, and presence of Th17 cells in the inflamed gingiva. However, underlying mechanism of Th17 differentiation and their role in the pathogenesis of CP is not known...
  10. MicroRNA expression in gingival tissues in periodontal health and disease
    Panos N Papapanou; Fiscal Year: 2013
    ..in our own full- genome transcriptomic database whether these predicted targets were indeed down-regulated in the gingiva. We will subsequently harvest gingival tissues from de novo recruited individuals, we will identify the specific ..
  11. Macrolide Accumulation by Host Cells in the Gingiva
    John D Walters; Fiscal Year: 2010
    ..Both agents can potentially attain higher levels in gingiva than in serum. Preliminary studies suggest that active transport plays an important role in this process...
  12. Novel Genetic Approach To Isolate Stem Cells Of The Oral Cavity
    Satrajit Sinha; Fiscal Year: 2012
    ..stem cells from the mouse oral epithelium at discrete anatomical sites such as buccal mucosa, palate and gingiva. Importantly, our strategy will permit the isolation of viable stem cells that can be subsequently analyzed in ..
  13. PHENYTOIN PATHOGENESIS OF GINGIVAL OVERGROWTH
    Thomas Hassell; Fiscal Year: 1990
    ..g., chromosome breakage, sister chromatid exchange) will be performed on fibroblasts from overgrown gingiva, with and without in vitro exposure to the drug...
  14. Subgingival Drug Delivery for Periodontitis Prevention and Treatment
    MARTYN DARBY; Fiscal Year: 2009
    ..In the current proposal, we aim to target antibiotics directly to teeth and gingiva using high-affinity peptides fostering the retention and sustained release of antibiotics in regions susceptible ..
  15. ORAL MUCOSA MICROBIOTA IN HEALTH, CANCER & MUCOSITIS
    Donna Mager; Fiscal Year: 2004
    ..dorsum, lateral and ventral surfaces of the tongue, floor of mouth, cheek, hard palate, vestibule/lip, attached gingiva and saliva as well as supra and subgingival plaque of the mesial aspect of each tooth in each subject...
  16. Mandibular Bone transport Reconstruction Plate
    LYNNE OPPERMAN; Fiscal Year: 2006
    ..Reconstruction of the lower jaw typically involves bone, gingiva, and teeth...
  17. Novel mandibular bone transport reconstruction plate
    LYNNE OPPERMAN; Fiscal Year: 2003
    ..Reconstruction of the lower jaw typically involves bone, gingiva, and teeth...
  18. ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    Caroline Damsky; Fiscal Year: 1999
    ..mechanisms of development and remodeling in two tissues important for craniofacial and dental health, bone and gingiva. These tissues have in common the property of being extremely dynamic...
  19. DENDRITIC CELLS & ACTINOBACILLUS ACTINOMYCETEMCOMITANS
    Paul Ezzo; Fiscal Year: 2004
    ..This hypothesis will be addressed by the following aims: 1) to characterize in situ the DC subsets found in gingiva from UP patients before and after clinical treatment, 2) to isolate and characterize DCs from UP patients, and 3) ..
  20. GROWTH FACTOR BIOAVAILABILITY AND GINGIVAL OVERGROWTH
    MARY FARACH CARSON; Fiscal Year: 2000
    ..growth factor 2 (FGF-2), has been implicated in the development of overgrowth disease, including that of the gingiva. Following its biosynthesis, bFGF is sequestered by the extracellular matrix (ECM), and it is release of bFGF ..
  21. RECONSTRUCTED HUMAN GINGIVAL TISSUE
    Mitchell Klausner; Fiscal Year: 2000
    ..testing of new pharmacological agents and therapies to combat the various diseases and disorders affecting the gingiva. In addition, an organotypic tissue model of the gingival epithelium would be useful for dental implant ..
  22. Biomimetics for Dentin Regeneration
    R Rutherford; Fiscal Year: 2003
    ..and non-mineralized scaffolds will be tested with and without allogeneic stem cells cultured from dental pulp and gingiva. The rationale for this study derives from our data that experimental protein and ex vivo gene therapies induce ..
  23. MOLECULAR ANALYSIS OF SUBGINGIVAL MICROBIAL DIVERSITY
    David Relman; Fiscal Year: 2003
    ..and archaeal contribution to the total microbial population within subgingival plaque associated with healthy gingiva, plaque-associated gingivitis and chronic adult periodontitis...
  24. Systematic Design of Biomimetic Basement Membranes
    Michael Caplan; Fiscal Year: 2006
    ..for dental applications, a bioactive material would be able to strengthen binding of the epithelial lining of the gingiva to the implant in order to exclude bacteria from the subepithelial gingival tissue...
  25. OXIDATIVE PMN/PERIODONTIUM INTERACTION IN ORAL DISEASE
    Susan Mallery; Fiscal Year: 1990
    It is well recognized that periodontal pathology (loss of integrity of tooth supporting bone and gingiva) is responsible for the majority of adult tooth loss...
  26. GENETIC POLYMORPHISMS OF BETA-DEFENSINS IN ORAL DISEASES
    ROBERT CHADWICK; Fiscal Year: 2000
    ..Oral epithelial cells from gingiva have been recently shown to express antimicrobial peptides of the beta-defensin family, which are proposed to ..
  27. ANTI-DESMOSOMAL ANTIBODIES IN PERIODONTITIS
    YAKOV GOVZE; Fiscal Year: 1993
    ..Elevated titers of naturally occurring antibodies against desmosomal proteins in the gingiva, we hypothesize, would contribute to the proliferation of the epithelial attachment, a key sign of periodontitis...
  28. MICROBE PATHOGEN GENOME PROJECT--A ACTINOMYCETEMCOMITANS
    David Dyer; Fiscal Year: 1999
    ..LJP is a chronic inflammatory disease of the gingiva (gums) and underlying bony tissues, with no effective prevention...
  29. GLYCATION, RECEPTORS, CYTOKINES IN PERIODONTAL DISEASE
    Ann Schmidt; Fiscal Year: 2000
    ..hypothesis underlying the accelerated periodontal disease (PD) in patients with diabetes: AGEs in diabetic gingiva stimulate ECs via RAGE, enhance expression of VCAM-1, and increase leakage of plasma; MPs attracted to the ..
  30. INITIATORS AND MEDIATORS IN PERIODONTAL DISEASE
    EDWARD MONTGOMERY; Fiscal Year: 1980
    ..separation of inflammation-inducing components as assessed by the topical application of these fractions to the gingiva of beagle dogs (a model which simulates periodontal disease)...
  31. IN VITRO INVASION MODEL FOR PERIODONTOPATHOGENS
    Paula Fives Taylor; Fiscal Year: 1991
    ..Of these diseases, periodontitis is the most common and results when inflammation in the gingiva is extended to the connective tissue attachment and alveolar bone supporting teeth...
  32. PROPERTIES OF HIGH THRESHOLD MECHANORECEPTORS
    Brian Cooper; Fiscal Year: 1993
    This proposal examines the properties of high threshold mechanoreceptors in the gingiva of the oral cavity. Teased fiber techniques will be used to record from single afferents of the inferior alveolar nerve of the goat...
  33. GENETIC DISSECTION OF MURINE PERIODONTAL WOUND HEALING
    Ellen Heber Katz; Fiscal Year: 2001
    ..the tissues investing and supporting teeth, includes aveolar bone, root cementum, periodontal ligament, and gingiva. It is generally accepted that the etiology of periodontal disease(s) is infectious in origin, however, ..
  34. IDENTIFICATION OF GENES CAUSING GINGIVAL FIBROMATOSIS
    Ok Hee Ryu; Fiscal Year: 2001
    ..Gingival fibromatosis refers to a clinical condition that involves enlargement of the keratinized gingiva surrounding the teeth...
  35. MOLECULAR MECHANISMS OF PERIODONTAL DISEASE
    M Hussain; Fiscal Year: 1990
    ..We propose that DNA repair capability of cells in the chronically inflamed gingiva is depressed...
  36. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    DESCRIPTION: Bacterial infections of the teeth and gingiva commonly cause tooth decay and periodontal disease, but may also cause serious systemic diseases such as endocarditis...
  37. ORAL TISSUE ENGINEERING
    R Rutherford; Fiscal Year: 2002
    ..tissues be utilized? Little is known about the capacity of cells cultured from oral tissues such as pulp and gingiva to effect tissue repair in vivo, however recent data reveal that the potential of cells varies with tissue source...
  38. Cell-Cell & Cell Stroma Regulation in Oral Premalignancy
    Peter Sacks; Fiscal Year: 2006
    ..and microenvironmental complexity increased by addition of various ECMs and fibroblasts (derived from normal gingiva, dysplastic leukoplakia or tumor)...
  39. CELL ADHESION MOLECULES IN GINGIVAL TISSUES
    John Crawford; Fiscal Year: 1992
    ..to compare the adhesion of lymphocytes and PMNS to sections of healthy and diseased gingiva; 3...
  40. PROSTAGLANDINS AND THROMBOXANE IN PERIODONTAL DISEASES
    Patrick Wong; Fiscal Year: 1980
    ..Preliminary studies had shown the prostaglandin E2 levels are elevated in diseased human gingiva and may, therefore, participate in the pathogenesis of peridontal disease...
  41. Induction of intergrating NF-kB by P gingivalis LPS
    Cun Yu Wang; Fiscal Year: 2007
    ..Periodontal diseases are chronic Gram-negative anaerobic bacterial infections leading to inflammation of the gingiva and destruction of periodontal tissues. Several bacteria including Porphyromonos gingiva/is (P...
  42. PROSPECTIVE EVALUATION OF IMPLANT SUPPORTED BRIDGES
    Michael Block; Fiscal Year: 2000
    ..implants and natural teeth will be evaluated using measurements of gingival bleeding, plaque and calculus indices, presence of attached gingiva, vertical bone loss using standard radiographs, and tooth and implant mobility.
  43. LOCALIZATION IN GINGIVA OF BONE RESORPTION MEDIATORS
    KLAUS NUKI; Fiscal Year: 1980
    ..bone loss in periodontal disease, by determining as closely as possible which structural components of inflamed gingiva are associated with in vitro bone resorbing activity...
  44. MMP EXPRESSION IN A NOVEL IN VITRO WOUND HEALING MODEL
    Nadeem Karimbux; Fiscal Year: 2001
    ..In Aim 1, an in vitro gingival wound healing model will be established using surgical specimens of human gingiva. The specimens will be obtained from routine graft procedures, second stage implant or periodontal flap surgeries,..
  45. RESEARCH CENTER IN ORAL BIOLOGY
    Suzanne Michalek; Fiscal Year: 1999
    ..A body of evidence suggests that cytokines and growth factors induced locally in the gingiva in response to microbial colonization mobilize a network of host cell interactions that ultimately results in ..
  46. IMPAIRED WOUND SIGNALING IN DIABETIC PERIODONTITIS
    Anthony Iacopino; Fiscal Year: 1999
    ..systemic wound healing deficit that manifests as PD in the face of constant pathologic wounding of the gingiva (bacterial plaque) or delayed dermal wound healing in instances of periodic traumatic wounding to other parts of ..
  47. A DEVICE FOR REPAIR OF MUCOGINGIVAL TISSUE
    Alan Spievack; Fiscal Year: 2001
    ..Cells harvested from either attached gingiva or buccal mucosa will be used to seed either of these substrates and the resulting engineered tissue will ..
  48. RNAi Gene Therapy Intended for Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2005
    ..is characterized by chronic inflammation associated with multiple bacterial infections in the crevice between gingiva and tooth, resulting in soft tissue destruction and bone resorption...
  49. CELLULAR INFILTRATES IN HUMAN PERIODONTAL DISEASE
    BRUCE MACKLER; Fiscal Year: 1980
    ..second experimental approach will be to recover gingival lymphocytes and other inflammatory cells, from diseased gingiva, then characterize these cells using surface markers...
  50. CELLULAR AND MOLECULAR TARGETING OF TMJ DESTRUCTION
    DAVID TIPTON; Fiscal Year: 2002
    ..It is hoped that completion of these three aims will provide a detailed knowledge of the biological basis of TMJ destruction via synovial fibroblasts and MMP pathway. ..
  51. Diabetes: Implant Integration, Success, and Benefit
    Thomas W Oates; Fiscal Year: 2010
    ..Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes. ..
  52. Epithelial Innate Immune Response to Oral Bacteria
    WHASUN CHUNG; Fiscal Year: 2008
    ..This work will lay the groundwork for identifying new therapeutic targets to prevent and treat periodontal diseases. [unreadable] [unreadable]..
  53. Aggressive Periodontitis and Formylpeptide Receptor SNPs
    John Walters; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. Regulation of Human Beta-Defensins in Epithelia
    WHASUN CHUNG; Fiscal Year: 2006
    ..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
  55. Uptake of Fluoroquinolones and Tetracyclines by Gingiva
    John Walters; Fiscal Year: 2003
    ..Epithelial cells in the gingiva also take up these agents, providing access to intracellular pathogens...
  56. Regulation of Beta-Defensin Expression in Oral Epithelia
    WHASUN CHUNG; Fiscal Year: 2009
    ..These studies will lead to new insights on the role of innate immunity and new potential targets for therapeutic drug development for oral infections. ..
  57. C1Q-INDUCED CA2+ RESPONSES IN FIBROBLAST HETEROGENEITY
    Sandra Bordin; Fiscal Year: 2002
    ..that control proliferation of distinct populations of normal and granulation fibroblasts cultured from human gingiva. These studies led us to scrutinize how the anti-microbial complement component C1q, which occurs in high ..