mandible

Summary

Summary: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.

Top Publications

  1. ncbi Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes
    Riccardo d'Aquino
    Department of Experimental Medicine, Section of Histology and Embryology, TERM Division, 2nd University of Naples, Naples, Italy
    Eur Cell Mater 18:75-83. 2009
  2. doi Vertical alveolar ridge augmentation with beta-tricalcium phosphate and autologous osteoblasts in canine mandible
    Shaoyi Wang
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
    Biomaterials 30:2489-98. 2009
  3. pmc Model sensitivity and use of the comparative finite element method in mammalian jaw mechanics: mandible performance in the gray wolf
    Zhijie Jack Tseng
    Integrative and Evolutionary Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e19171. 2011
  4. pmc Genetic architecture of mandible shape in mice: effects of quantitative trait loci analyzed by geometric morphometrics
    C P Klingenberg
    Laboratory of Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Genetics 157:785-802. 2001
  5. pmc Morphometric integration and modularity in configurations of landmarks: tools for evaluating a priori hypotheses
    Christian Peter Klingenberg
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Evol Dev 11:405-21. 2009
  6. pmc An Early Pleistocene hominin mandible from Atapuerca-TD6, Spain
    E Carbonell
    Area de Prehistoria, Universitat Rovira i Virgili, Plaza Imperial Tarraco 1, 43005 Tarragona, Spain
    Proc Natl Acad Sci U S A 102:5674-8. 2005
  7. ncbi Developmental integration in a complex morphological structure: how distinct are the modules in the mouse mandible?
    Christian Peter Klingenberg
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 5:522-31. 2003
  8. doi Is Homo heidelbergensis a distinct species? New insight on the Mauer mandible
    Aurélien Mounier
    Unité d Anthropologie Adaptabilité Bioculturelle, UMR 6578, CNRS, Universite de la Mediterranee, EFS, Faculte de Medecine Secteur Nord, Marseille, France
    J Hum Evol 56:219-46. 2009
  9. ncbi Variations in cortical material properties throughout the human dentate mandible
    C L Schwartz-Dabney
    Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9109, USA
    Am J Phys Anthropol 120:252-77. 2003
  10. doi The first hominin of Europe
    Eudald Carbonell
    Institut Català de Paleoecologia humana i Evolució Social, Area de Prehistoria, Universitat Rovira i Virgili, Placa Imperial Tarraco 1, 43005 Tarragona, Spain
    Nature 452:465-9. 2008

Detail Information

Publications351 found, 100 shown here

  1. ncbi Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes
    Riccardo d'Aquino
    Department of Experimental Medicine, Section of Histology and Embryology, TERM Division, 2nd University of Naples, Naples, Italy
    Eur Cell Mater 18:75-83. 2009
    ..This clinical study demonstrates that a DPC/collagen sponge biocomplex can completely restore human mandible bone defects and indicates that this cell population could be used for the repair and/or regeneration of tissues ..
  2. doi Vertical alveolar ridge augmentation with beta-tricalcium phosphate and autologous osteoblasts in canine mandible
    Shaoyi Wang
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
    Biomaterials 30:2489-98. 2009
    ..This study demonstrated the potential of porous beta-TCP as a substrate for autogenous osteoblasts in bone tissue engineering for alveolar ridge augmentation...
  3. pmc Model sensitivity and use of the comparative finite element method in mammalian jaw mechanics: mandible performance in the gray wolf
    Zhijie Jack Tseng
    Integrative and Evolutionary Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 6:e19171. 2011
    ..Simulations were performed on FE models of a Gray Wolf (Canis lupus) mandible. Results showed that unilateral bite force outputs are least affected by the relative ratios of the balancing and ..
  4. pmc Genetic architecture of mandible shape in mice: effects of quantitative trait loci analyzed by geometric morphometrics
    C P Klingenberg
    Laboratory of Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Genetics 157:785-802. 2001
    ..for analyzing the effects of quantitative trait loci (QTL) on shape and demonstrates this method for the mouse mandible. We quantified size and shape with the methods of geometric morphometrics, based on Procrustes superimposition of ..
  5. pmc Morphometric integration and modularity in configurations of landmarks: tools for evaluating a priori hypotheses
    Christian Peter Klingenberg
    Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Evol Dev 11:405-21. 2009
    ..I propose a criterion for spatial contiguity for sets of landmarks using an adjacency graph. The new methods are demonstrated with data on shape of the wing in Drosophila melanogaster and the mandible of the house mouse.
  6. pmc An Early Pleistocene hominin mandible from Atapuerca-TD6, Spain
    E Carbonell
    Area de Prehistoria, Universitat Rovira i Virgili, Plaza Imperial Tarraco 1, 43005 Tarragona, Spain
    Proc Natl Acad Sci U S A 102:5674-8. 2005
    We present a mandible recovered in 2003 from the Aurora Stratum of the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain)...
  7. ncbi Developmental integration in a complex morphological structure: how distinct are the modules in the mouse mandible?
    Christian Peter Klingenberg
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 5:522-31. 2003
    The mouse mandible has long served as a model system for studying the development and evolution of complex morphological structures...
  8. doi Is Homo heidelbergensis a distinct species? New insight on the Mauer mandible
    Aurélien Mounier
    Unité d Anthropologie Adaptabilité Bioculturelle, UMR 6578, CNRS, Universite de la Mediterranee, EFS, Faculte de Medecine Secteur Nord, Marseille, France
    J Hum Evol 56:219-46. 2009
    ..g., Tighenif) and European (e.g., Sima de los Huesos) specimens that show a close relationship with the Mauer mandible. Therefore, the definition of H...
  9. ncbi Variations in cortical material properties throughout the human dentate mandible
    C L Schwartz-Dabney
    Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9109, USA
    Am J Phys Anthropol 120:252-77. 2003
    ..Like all other material property studies in individual bone organs, studies of the human mandible are limited by a low number of both specimens and sampled regions...
  10. doi The first hominin of Europe
    Eudald Carbonell
    Institut Català de Paleoecologia humana i Evolució Social, Area de Prehistoria, Universitat Rovira i Virgili, Placa Imperial Tarraco 1, 43005 Tarragona, Spain
    Nature 452:465-9. 2008
    ..Here we report the discovery of a human mandible associated with an assemblage of Mode 1 lithic tools and faunal remains bearing traces of hominin processing, in ..
  11. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    N Engl J Med 346:1513-21. 2002
    ..Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis-pseudoglioma...
  12. doi Root and canal morphology of mandibular second molars in an Indian population
    Prasanna Neelakantan
    Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India
    J Endod 36:1319-22. 2010
    ..There are no reports on the root canal anatomy of Indian mandibular second molars. The aim of this study was to investigate the root and canal morphology of Indian mandibular second molars by a canal staining and tooth clearing technique...
  13. doi Density of the alveolar and basal bones of the maxilla and the mandible
    Hyo Sang Park
    Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, Korea
    Am J Orthod Dentofacial Orthop 133:30-7. 2008
    The purpose of this investigation was to quantitatively evaluate density of the alveolar and basal bones of the maxilla and the mandible.
  14. doi Evaluation of root and canal systems of mandibular first molars in Taiwanese individuals using cone-beam computed tomography
    Chih Chia Huang
    Department of Dentistry, Cardinal Tien Hospital, Taipei, Taiwan
    J Formos Med Assoc 109:303-8. 2010
    ..Cone-beam computed tomography (CBCT) can provide valuable data for root canal systems of human teeth. This study used CBCT to evaluate the number of roots and canals in mandibular first molars in Taiwanese individuals...
  15. doi Patterns of covariation in the masticatory apparatus of hystricognathous rodents: implications for evolution and diversification
    Lionel Hautier
    Museum of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    J Morphol 273:1319-37. 2012
    ..in the genesis of shape brings new insights on the relationships between morphological changes in the cranium, mandible, and muscle architecture...
  16. doi Human bone morphogenetic protein 2-transduced mesenchymal stem cells improve bone regeneration in a model of mandible distraction surgery
    Yanko Castro-Govea
    Service of Plastic and Reconstructive Surgery, School of Medicine and University Hospital of the Universidad Autónoma de Nuevo León, Monterrey, Mexico
    J Craniofac Surg 23:392-6. 2012
    ..Gene therapy for bone regeneration using adenovirus-expressing BMPs has been successful in small mammals, but it has not been satisfactory in large mammals...
  17. ncbi Root and canal morphology of Thai mandibular molars
    K Gulabivala
    Department of Conservative Dentistry, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Int Endod J 35:56-62. 2002
    ..To investigate the root and canal morphology of 351 mandibular permanent molars collected from an indigenous Thai population...
  18. pmc A comparative assessment of mandible shape in a consomic strain panel of the house mouse (Mus musculus)--implications for epistasis and evolvability of quantitative traits
    Louis Boell
    Max Planck Institut für Evolutionsbiologie, August Thienemannstrasse 2, 24306 Plön, Germany
    BMC Evol Biol 11:309. 2011
    ..This question is especially relevant for shape, where the high dimensionality of variation seems to require a highly complex genetic architecture involving many genes...
  19. doi Standards of soft tissue Arnett analysis for surgical planning in Turkish adults
    Tancan Uysal
    Department of Orthodontics, Erciyes University, Kayseri, Turkey
    Eur J Orthod 31:449-56. 2009
    ..These differences between ethnic groups should be taken into consideration when formulating orthodontic/orthognathic treatment plans for patients with dentofacial deformity...
  20. doi C-shaped root canal system in mandibular second molars in a Chinese population evaluated by cone-beam computed tomography
    Q Zheng
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
    Int Endod J 44:857-62. 2011
    ..To evaluate the anatomical features of C-shaped canal systems in Chinese mandibular second molars by cone-beam computed tomography (CBCT)...
  21. ncbi Reconstruction of the mandible with osseous free flaps: a 10-year experience with 150 consecutive patients
    P G Cordeiro
    Plastic and Reconstructive Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 104:1314-20. 1999
    ..Of 457 head and neck free flaps, 150 osseous mandible reconstructions were performed over a 10-year period...
  22. pmc The Ay allele at the agouti locus reduces the size and alters the shape of the mandible in mice
    Jun ichi Suto
    Division of Animal Sciences, National Institute of Agrobiological Sciences, Ibaraki, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 85:248-57. 2009
    To confirm my previous findings that the A(y) allele at the agouti locus reduced the mandible size and therefore altered the mandible shape in a KK mouse strain background, I further investigated the effects of the A(y) allele on mandible ..
  23. doi Toward integration of geometric morphometrics and computational biomechanics: new methods for 3D virtual reconstruction and quantitative analysis of Finite Element Models
    W C H Parr
    School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Theor Biol 301:1-14. 2012
    ..based on freely available software and test the effectiveness of the approach in FEA using the varanoid lizard mandible as a model...
  24. ncbi Histological evaluation of the effect of low-level laser on distraction osteogenesis in rabbit mandibles
    Paulo Eduardo Kreisner
    School of Dentistry, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Med Oral Patol Oral Cir Bucal 15:e616-8. 2010
    ..This study evaluated the action of low level laser therapy (LLLT) on the percentage of newly formed bone in rabbit mandibles that underwent distraction osteogenesis (DO)...
  25. ncbi The mental foramen and nerve: clinical and anatomical factors related to dental implant placement: a literature review
    Gary Greenstein
    Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY, USA
    J Periodontol 77:1933-43. 2006
    ..Its location and the possibility that an anterior loop of the mental nerve may be present mesial to the mental foramen needs to be considered before implant surgery to avoid mental nerve injury...
  26. ncbi Effect of cortical bone thickness and implant placement torque on stability of orthodontic mini-implants
    Mitsuru Motoyoshi
    Department of Orthodontics, Nihon University School of Dentistry, Tokyo, Japan
    Int J Oral Maxillofac Implants 22:779-84. 2007
    ....
  27. ncbi Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review
    Antonio Caso
    University of Washington School of Dentistry, Department of Oral and Maxillofacial Surgery, Seattle, WA 98195 7134, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:155-9. 2005
    ..The objective of this study was to assess if chlorhexidine (CHX) rinse decreases the occurrence of alveolar osteitis (AO) following third molar removal...
  28. ncbi Relationship between facial types and tooth and bone characteristics of the mandible obtained by CT scanning
    M Tsunori
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    Angle Orthod 68:557-62. 1998
    ..The morphological features that relate to masticatory function and facial types are associated with cortical bone thickness of the mandibular body and the buccolingual inclination of the first and second molars...
  29. doi Root anatomy and canal configuration of the permanent mandibular first molar: a systematic review
    Oliver Valencia de Pablo
    Department of Endodontics, Universidad Europea de Madrid, Madrid, Espana
    J Endod 36:1919-31. 2010
    ..The purpose of this study was to review published literature related to root anatomy and root canal configuration of the permanent mandibular first molar...
  30. ncbi Evaluation of periapical radiographs in the recognition of C-shaped mandibular second molars
    T Lambrianidis
    Department of Endodontology, Dental School, Aristotelian University, Thessaloniki, Greece
    Int Endod J 34:458-62. 2001
    ....
  31. ncbi The influence of Bio-Oss Collagen on healing of an extraction socket: an experimental study in the dog
    Mauricio Araújo
    Department of Dentistry, State University of Maringa, Parana, Brazil
    Int J Periodontics Restorative Dent 28:123-35. 2008
    ..The placement of a biomaterial in an extraction socket may promote bone modeling and compensate, at least temporarily, for marginal ridge contraction...
  32. ncbi Hemorrhaging associated with endosseous implant placement in the anterior mandible: a review of the literature
    Christos D R Kalpidis
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, MA, USA
    J Periodontol 75:631-45. 2004
    ..review presents critical hemorrhagic episodes, related to dental implantation in the anterior segments of the mandible, published to date...
  33. doi Biomechanical study of mandible bone supporting a four-implant retained bridge: finite element analysis of the influence of bone anisotropy and foodstuff position
    A S Bonnet
    Laboratory of Mechanics, Biomechanics, Polymers and Structures LaBPS, ENIM, Ile du Saulcy 57045 Metz, France
    Med Eng Phys 31:806-15. 2009
    ..The influence of foodstuff position during mastication was also analysed...
  34. ncbi Treatment effects produced by Fränkel appliance in patients with class II, division 1 malocclusion
    Marcio Rodrigues de Almeida
    Lins Dental School, Methodist University of Piracicaba, Lins City, Sao Paulo, Brazil
    Angle Orthod 72:418-25. 2002
    ..It was concluded that the main effects of the Fränkel appliance during this time period were mostly dentoalveolar with a smaller but significant skeletal mandibular effect...
  35. ncbi Endodontic treatment of a mandibular second premolar with four canals using operating microscope
    Giorgos N Tzanetakis
    Department of Endodontics, Dental School, University of Athens, Athens, Greece
    J Endod 33:318-21. 2007
    ..8x, and 19.1x)...
  36. ncbi C-shaped root canals in mandibular second molars in a Saudi Arabian population
    K S Al-Fouzan
    Dental Department, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia
    Int Endod J 35:499-504. 2002
    ..The aim of this study was to determine the frequency of C-shaped canals in mandibular second molars in a population in Saudi Arabia and to establish a classification for the most common configurations...
  37. ncbi The application of mini-implants for orthodontic anchorage
    Y C Tseng
    Department of Orthodontics, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Oral Maxillofac Surg 35:704-7. 2006
    ..1%. The location of the implant was the significant factor related to failure. In conclusion, the mini-implants are easy to insert for skeletal anchorage and could be successful in the control of tooth movement...
  38. ncbi Implant treatment in the edentulous mandible: a prospective study on Brånemark system implants over more than 20 years
    Jan Anders Ekelund
    Specialist Prosthetic Center, Boras, Sweden
    Int J Prosthodont 16:602-8. 2003
    ..This prospective investigation studied the clinical and radiographic performance of mandibular fixed prostheses supported by osseointegrated implants over more than 20 years...
  39. ncbi Mandibular distraction in neonates: a strategy to avoid tracheostomy
    Arlen Denny
    Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Plast Reconstr Surg 109:896-904; discussion 905-6. 2002
    ..In selected Pierre Robin sequence patients with tongue base airway obstruction, mandibular distraction osteogenesis can successfully avoid the need for and the associated mortality and morbidity of indwelling tracheostomy...
  40. ncbi Influence of lower third molar position on the incidence of preoperative complications
    Nieves Almendros-Marqués
    School of Dentistry, University of Barcelona, Barcelona, Spain
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:725-32. 2006
    ....
  41. ncbi Low-level laser effect on mandibular distraction osteogenesis
    Michael Miloro
    Section of Oral and Maxillofacial Surgery, University of Nebraska Medical Center, Omaha, NE 68198 5180, USA
    J Oral Maxillofac Surg 65:168-76. 2007
    ....
  42. pmc Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis
    Olga Golonzhka
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 106:4278-83. 2009
    ..Perturbations of gene expression were also observed in the mandible of Ctip2(-/-) mice: expression of the ameloblast markers amelogenin, ameloblastin, and enamelin was down-..
  43. ncbi Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT)
    Gabriela Studer
    Department of Radiation Oncology, University Hospital, Zurich, Switzerland
    Strahlenther Onkol 182:283-8. 2006
    Osteoradionecrosis (ON) of the mandible is a serious late complication of high-dose radiation therapy for tumors of the oropharynx and oral cavity...
  44. ncbi Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
    Y Chai
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 127:1671-9. 2000
    ..of a two-component genetic system for indelibly marking the progeny of the cranial neural crest during tooth and mandible development...
  45. ncbi C-shaped canal system in mandibular second molars: Part I--Anatomical features
    Bing Fan
    Key Lab for Oral Biomedical Engineering of Ministry of Education, Endodontic Center, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Endod 30:899-903. 2004
    ..Section 2 of this paper addressed the correlation between the radiographic appearance and these microCT images...
  46. ncbi Root and canal morphology of permanent mandibular molars in a Sudanese population
    H A Ahmed
    Conservative Dentistry Division, Department of Oral Rehabilitation, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan
    Int Endod J 40:766-71. 2007
    ..To investigate variations in the root canal systems of first and second permanent mandibular molar teeth in a Sudanese population using a clearing technique...
  47. doi Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis
    Konstantinos Z Vlasiadis
    Dental Clinic, University Hospital of Crete, Iraklion Crete, Greece
    Maturitas 59:226-33. 2008
    ..Recent studies suggest that radiographic examination of mandible may constitute an effective process for the early diagnosis of osteoporosis...
  48. ncbi Influence of the size of the microgap on crestal bone changes around titanium implants. A histometric evaluation of unloaded non-submerged implants in the canine mandible
    J S Hermann
    Department of Periodontics, Dental School, University of Texas Health Science Center at San Antonio, TX, USA
    J Periodontol 72:1372-83. 2001
    ..These findings demonstrate, as evaluated by non-decalcified histology under unloaded conditions in the canine mandible, that crestal bone changes around 2-piece, non-submerged titanium implants are significantly influenced by ..
  49. ncbi Histology of retrieved immediately and early loaded oxidized implants: light microscopic observations after 5 to 9 months of loading in the posterior mandible
    Antonio Rocci
    Clin Implant Dent Relat Res 5:88-98. 2003
    ..However, little is known about the histologic response to implants subjected to immediate/early loading in patients...
  50. doi New method for analysis of facial growth in a pediatric reconstructed mandible
    Chung How Kau
    Department of Orthodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Am J Orthod Dentofacial Orthop 139:e285-90. 2011
    The aim of this article was to present a new method of analysis for the assessment of facial growth and morphology after surgical resection of the mandible in a growing patient.
  51. doi Bone response to loaded implants with non-matching implant-abutment diameters in the canine mandible
    David L Cochran
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Periodontol 80:609-17. 2009
    ..The objective of this study was to histologically evaluate the alveolar bone change around a bone-level, non-matching implant-abutment diameter configuration that incorporated a horizontal offset and a Morse taper internal connection...
  52. ncbi Quality assessment of the cortical bone of the human mandible
    S Lettry
    Bioengineering Division, Rheumatology and Rehabilitation Research Unit, School of Medicine, Leeds University, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Bone 32:35-44. 2003
    ..and the directional variations in mechanical properties and computed tomography (CT) numbers of the fresh mandible bone and to explore the correlation between the two sets of data with a view to provide a noninvasive method for ..
  53. pmc Juvenile hormone regulates extreme mandible growth in male stag beetles
    Hiroki Gotoh
    Laboratory of Ecological Genetics, Graduate School of Environmental Science, Hokkaido University, Sapporo, Japan
    PLoS ONE 6:e21139. 2011
    ..Combined, our results support a role for JH in the nutrition-dependent regulation of extreme mandible growth in this species...
  54. pmc Remodeling dynamics in the alveolar process in skeletally mature dogs
    Sarandeep S Huja
    Section of Orthodontics, College of Dentistry, Ohio State University, Columbus, Ohio 43210, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:1243-9. 2006
    ..05) in the BV/TV within the jaws. The bone volume within the alveolar process of the mandible was 2.8-fold greater than in the maxilla...
  55. doi Influence of a machined collar on crestal bone changes around titanium implants: a histometric study in the canine mandible
    Joachim S Hermann
    Department of Periodontics, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, Texas
    J Periodontol 82:1329-38. 2011
    ..Thus, the purpose of this study is to histometrically examine crestal bone changes around machined versus SLA-surfaced implant collars in a side-by-side comparison...
  56. ncbi On the taxonomic affinities of the Dmanisi mandible (Georgia)
    A Rosas
    Department of Paleobiology, Museo Nacional de Ciencias Naturales, Madrid, Spain
    Am J Phys Anthropol 107:145-62. 1998
    ..The Dmanisi mandible is perhaps one of the most interesting findings, as it supposedly represents one of the oldest hominids outside ..
  57. ncbi Growth modification of the rabbit mandible using therapeutic ultrasound: is it possible to enhance functional appliance results?
    Tarek El-Bialy
    Department of Orthodontics, Tanta University, Tanta, Egypt
    Angle Orthod 73:631-9. 2003
    ..They received therapeutic US on one side of the mandible for 20 minutes/day for four weeks...
  58. doi Biologic width changes around loaded implants inserted in different levels in relation to crestal bone: histometric evaluation in canine mandible
    Ana Emilia Farias Pontes
    FEB Educational Foundation of Barretos, School of Dentistry, Barretos, SP, Brazil
    Clin Oral Implants Res 19:483-90. 2008
    ..The aim of the present study was to evaluate histometric changes around dental implants inserted at different levels in relation to the crestal bone, under different loading conditions...
  59. ncbi Vertical ridge augmentation of the atrophic posterior mandible with interpositional block grafts: bone from the iliac crest versus bovine anorganic bone
    Pietro Felice
    Department of Periodontology and Implantology, University of Bologna, Bologna, Italy
    Eur J Oral Implantol 1:183-98. 2008
    ..complications and patient preference of two different techniques for vertical bone augmentation of the posterior mandible: bone blocks harvested from the iliac crest versus anorganic bovine bone blocks (Bio-Oss(R)) were used as inlays.
  60. ncbi Immediate occlusal loading of implants in the partially edentate mandible: a prospective 1-year radiographic and 4-year clinical study
    Pär Olov Ostman
    Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    Int J Oral Maxillofac Implants 23:315-22. 2008
    ..was to evaluate the radiographic and clinical outcome of immediately loaded implants in the partial edentulous mandible over a 4-year follow-up period using a modified surgical protocol, primary implant stability criteria, and ..
  61. doi Use of cone-beam computed tomography to evaluate root and canal morphology of mandibular molars in Chinese individuals
    R Zhang
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    Int Endod J 44:990-9. 2011
    ..To evaluate the root canal configuration of permanent mandibular first and second molar teeth in a Chinese subpopulation using cone-beam computed tomography (CBCT)...
  62. doi The lip-splitting mandibulotomy: aesthetic and functional outcomes
    Peter T Dziegielewski
    Division of Otolaryngology Head and Neck Surgery, 1E4 University of Alberta Hospital, 8440 112 Street NW, Edmonton, Alberta, Canada T6G 2B7
    Oral Oncol 46:612-7. 2010
    ..05). The LSMA provides satisfactory scarring and low self-perception of disfigurement for patients. Moreover, the LSMA does not impact lower-lip sensation, movement or oral continence...
  63. doi Surgical aspects of a lower face, mandible, and tongue allotransplantation
    Pedro C Cavadas
    Department of Reconstructive Surgery, Clinica Cavadas, Valencia, Spain
    J Reconstr Microsurg 28:43-7. 2012
    ..aspects of a composite lower face transplantation including the tongue, floor of the mouth, and most of the mandible are detailed. The transplantation was performed in August 2009 in an HIV-positive, postoncologic patient...
  64. doi Evaluation of the visibility and the course of the mandibular incisive canal and the lingual foramen using cone-beam computed tomography
    Nikos Makris
    Department of Oral Diagnosis and Radiology, Dental School, University of Athens, Athens, Greece
    Clin Oral Implants Res 21:766-71. 2010
    ..To assess the visibility and the course of the incisive canal and the visibility and the location of the lingual foramen using cone-beam computed tomography (CBCT)...
  65. doi Bilateral sagittal split osteotomies and mandibular distraction osteogenesis: a randomized controlled trial comparing skeletal stability
    Andrew Ow
    Senior Resident, Oral and Maxillofacial Surgery, Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince Philip Dental Hospital, University of Hong Kong, Hong Kong, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:17-23. 2010
    ..To conduct a randomized controlled trial comparing the skeletal stability of bilateral sagittal split osteotomy (BSSO) and mandibular distraction ostoegenesis (MDO) for moderate mandibular advancement...
  66. ncbi Functional significance of strain distribution in the human mandible under masticatory load: numerical predictions
    I Ichim
    Department of Oral Sciences, Otago University, Walsh Building, 310 Great King Street, Dunedin 9001, New Zealand
    Arch Oral Biol 52:465-73. 2007
    ..along buccal and lingual surfaces of the mandibular corpus during mastication using a numerical model of a human mandible. We show that strain distribution differs in alveolar and mid-corpus segments of the mandible and that the latter ..
  67. doi Linear accuracy and reliability of cone beam CT derived 3-dimensional images constructed using an orthodontic volumetric rendering program
    Danielle R Periago
    Department of Orthodontic and Pediatric Dentistry, University of Louisville School of Dentistry, Louisville, KY, USA
    Angle Orthod 78:387-95. 2008
    ..To compare accuracy of linear measurements made on cone beam computed tomographic (CBCT) derived 3-dimensional (3D) surface rendered volumetric images to direct measurements made on human skulls...
  68. ncbi Myofibroma of the mandible
    Yasuyuki Shibuya
    Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Japan
    Kobe J Med Sci 54:E169-73. 2008
    This article is reporting a case of myofibroma involving the mandible of a 12-year-old boy. The patient did not have any swelling nor any redness but of partial mental nerve hypoesthesia...
  69. ncbi Runx2-deficient mice lack mandibular condylar cartilage and have deformed Meckel's cartilage
    S Shibata
    Maxillofacial Anatomy, Department of Maxillofacial Biology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Anat Embryol (Berl) 208:273-80. 2004
    ..showed that each mesenchymal condensation was connected to one another, and roughly outlined the shape of the mandible. Meckel's cartilage in the Runx2-deficient mice had two ectopic cartilaginous processes to which the digastric ..
  70. pmc Distribution of metals in the termite Tumulitermes tumuli (Froggatt): two types of Malpighian tubule concretion host Zn and Ca mutually exclusively
    Aaron D Stewart
    CSIRO Earth Science and Resource Engineering, Perth, Australia
    PLoS ONE 6:e27578. 2011
    ..Previously, Mn and Zn have been found concentrated in mandible tips and are associated with increased hardness whereas Ca, P, Mg and K are accumulated in Malpighian tubules...
  71. doi Sexual dimorphism of the human mandible and its association with dental development
    Michael Coquerelle
    Department of Anthropology, University of Vienna, 1090 Vienna, Austria
    Am J Phys Anthropol 145:192-202. 2011
    The present study investigates whether the human mandible is sexually dimorphic during early postnatal development and whether early dimorphic features persist during subsequent ontogeny...
  72. doi Mandible shape and dwarfism in squirrels (Mammalia, Rodentia): interaction of allometry and adaptation
    Lionel Hautier
    Laboratoire de Paléontologie, Institut des Sciences de l Evolution de Montpellier, UMR CNRS 5554, CC 064, Université de Montpellier 2, 2, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Naturwissenschaften 96:725-30. 2009
    ..The mandible of dwarf tree squirrels share a highly reduced coronoid process and a condylar process drawn backwards...
  73. ncbi New Middle Pleistocene human remains from northern Italy
    F Mallegni
    Universita degli Studi di Pisa, Dipartimento di Scienze Archeologiche, via S Maria 53 56100 Pisa, Italy
    Homo 52:233-9. 2002
    The description of several teeth and a fragment of mandible found in the Visogliano rock-shelter (Northern Italy) is presented in this paper...
  74. ncbi Ultrasound to stimulate early bone formation in a distraction gap: a double blind randomised clinical pilot trial in the edentulous mandible
    Jurjen Schortinghuis
    Department of Oral and Maxillofacial Surgery, Research Institute of Biomedical Engineering, Materials Science and Application, Groningen University Medical Centre, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Arch Oral Biol 50:411-20. 2005
    In a double blind randomised clinical pilot trial, it was investigated whether low intensity pulsed ultrasound therapy stimulates early bone formation in a distraction gap created in a severely resorbed mandible.
  75. ncbi Postural control of the human mandible
    Timothy S Miles
    Research Centre for Human Movement Control, The University of Adelaide, Adelaide, SA 5005, Australia
    Arch Oral Biol 52:347-52. 2007
    This article reviews recent experimental evidence explaining the mechanisms that support the mandible in its rest or postural position when the head is stationary and during locomotion...
  76. ncbi Growth modification of the mandible with ultrasound in baboons: a preliminary report
    Tarek El-Bialy
    University of Alberta, Edmonton, Alberta, Canada
    Am J Orthod Dentofacial Orthop 130:435.e7-14. 2006
    ..Before applying this treatment to humans, we must study the effect on mandibular growth in higher animal models. The objective of this study was to evaluate the effect of LIPUS on mandibular growth in baboons...
  77. doi Modeling the human mandible under masticatory loads: which input variables are important?
    Flora Gröning
    Department of Archaeology, University of York, York, UK
    Anat Rec (Hoboken) 295:853-63. 2012
    Finite element analyses (FEA) that have simulated masticatory loadings of the human mandible differ significantly with regard to their basic input variables such as material properties, constraints, and applied forces...
  78. ncbi Relationships between bone density values from cone beam computed tomography, maximum insertion torque, and resonance frequency analysis at implant placement: a pilot study
    Maria Ángeles Fuster-Torres
    Master of Oral Surgery and Implantology, Valencia University Medical and Dental School, Valencia, Spain
    Int J Oral Maxillofac Implants 26:1051-6. 2011
    ....
  79. doi Pattern and pace of dental eruption in Tarsius
    Emily H Guthrie
    Department of Anthropology, University of Oregon, Eugene, 97403, USA
    Am J Phys Anthropol 145:446-51. 2011
    ..The relatively and absolutely early eruption of the anterior dentition may be due to the utility of these front teeth in early food acquisition rather than with the pace of life history...
  80. doi Assessment of root canal morphology of mandibular first premolars in the Indian population using spiral computed tomography: an in vitro study
    Raghu Sandhya
    Department of Conservative Dentistry and Endodontics, Meenakshi Ammal Dental College and Hospital, Alapakkam Main Road, Maduravoyal, Chennai 602 102, India
    Indian J Dent Res 21:169-73. 2010
    ..The aim of the study is to determine the root canal morphology of the mandibular first premolar teeth in an Indian population using spiral computed tomography (SCT)...
  81. doi Dental implant outcome after primary implantation into double-barreled fibula osteoseptocutaneous free flap-reconstructed mandible
    Yang Ming Chang
    Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Plast Reconstr Surg 128:1220-8. 2011
    ..The aim of this study was to evaluate the quality and result of such reconstruction...
  82. doi Marsupialisation for keratocystic odontogenic tumours in the mandible: longitudinal image analysis of tumour size using 3D visualised CT scans
    H Shudou
    Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Int J Oral Maxillofac Surg 41:290-6. 2012
    The purpose of this study was to determine how keratocystic odontogenic tumours (KCOTs) in the mandible are reduced during marsupialisation, and to predict the best time for secondary enucleation by analysing computed tomography (CT) ..
  83. doi Root canal morphology of the mandibular first premolars in an Iranian population using cross-sections and radiography
    Sedigheh Khedmat
    Department of Endodontics, Faculty of Dentistry Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Endod 36:214-7. 2010
    ..This study was aimed to investigate the root canal anatomy of mandibular first premolars by both radiography and cross-sectional methods in an Iranian population...
  84. doi Random positional variation among the skull, mandible, and cervical spine with treatment progression during head-and-neck radiotherapy
    Peter H Ahn
    Department of Radiation Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA
    Int J Radiat Oncol Biol Phys 73:626-33. 2009
    With 54 degrees of freedom from the skull to mandible to C7, ensuring adequate immobilization for head-and-neck radiotherapy (RT) is complex. We quantify variations in skull, mandible, and cervical spine movement between RT sessions.
  85. pmc TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development
    Kyoko Oka
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 321:303-9. 2008
    Transforming growth factor-beta (TGF-beta) signaling is crucial for mandible development...
  86. doi Constraint and opportunity: the genetic basis and evolution of modularity in the cichlid mandible
    Kevin J Parsons
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    Am Nat 179:64-78. 2012
    ..Here we explore these ideas in the cichlid mandible by investigating patterns of modularity at the clade and species levels and through the introduction of a new ..
  87. doi Accuracy of three-dimensional measurements obtained from cone beam computed tomography surface-rendered images for cephalometric analysis: influence of patient scanning position
    Bassam Hassan
    Department of Oral Radiology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    Eur J Orthod 31:129-34. 2009
    ..The findings indicate that measurements based on 3D CBCT surface images are accurate and that small variations in the patient's head position do not influence measurement accuracy...
  88. ncbi High-bone-mass disease and LRP5
    Michael P Whyte
    N Engl J Med 350:2096-9; author reply 2096-9. 2004
  89. doi Reliability of mandibular cortical index and mandibular bone mineral density in the detection of osteoporotic women
    B Cakur
    Department of Oral Diagnosis and Oral Radiology, Ataturk University, Turkey
    Dentomaxillofac Radiol 38:255-61. 2009
    ....
  90. doi Three-dimensional evaluation of craniofacial asymmetry: an analysis using computed tomography
    Rosa María Yañez-Vico
    School of Dentistry, University of Seville, Seville, Spain
    Clin Oral Investig 15:729-36. 2011
    ..The angulation of the mandibular ramus, on both frontal and lateral planes, determines apparent facial asymmetry, as well as conditioning the surgical treatment plan for patients with craniofacial asymmetry...
  91. ncbi The surgical treatment of central giant cell granuloma of the mandible
    Anwar B Bataineh
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid, Jordan
    J Oral Maxillofac Surg 60:756-61. 2002
    ..The objective of this study was to report and evaluate our experience in the surgical treatment of mandibular central giant cell granuloma by resection without continuity defect and peripheral ostectomy...
  92. doi Free body analysis, beam mechanics, and finite element modeling of the mandible of Alligator mississippiensis
    Laura B Porro
    Department of Organismal Biology and Anatomy, University of Chicago, Illinois 60637, USA
    J Morphol 272:910-37. 2011
    ..architecture, accurate material properties, and three-dimensional mechanical behavior) of an extant archosaur mandible has never been carried out...
  93. doi Accuracy of linear measurements from cone-beam computed tomography-derived surface models of different voxel sizes
    Janalt Damstra
    Department of Orthodontics, University Medical Center Groningen, University of Groningen, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    Am J Orthod Dentofacial Orthop 137:16.e1-6; discussion 16-7. 2010
    ....
  94. doi Evolutionary modularity of the mouse mandible: dissecting the effect of chromosomal reorganizations and isolation by distance in a Robertsonian system of Mus musculus domesticus
    F Muñoz-Muñoz
    Departament de Biologia Animal, de Biologia Vegetal i d Ecologia, Facultat de Biociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Evol Biol 24:1763-76. 2011
    The mouse mandible consists of several morphogenetic units that are usually grouped into two main modules: the alveolar region and the ascending ramus...
  95. doi Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature
    Aldona W Woźniak
    Department of Clinical Pathomorphology, Poznan University of Medical Sciences, Ul Przybyszewskiego 49, 60 355 Poznan, Poland
    Eur Arch Otorhinolaryngol 267:845-9. 2010
    ....
  96. doi Mandibular molar root morphology in Neanderthals and Late Pleistocene and recent Homo sapiens
    Kornelius Kupczik
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    J Hum Evol 59:525-41. 2010
    ..and quantify the external and internal dental morphologies of both isolated molars and molars embedded in the mandible (n=127)...
  97. doi The nasomaxillary complex, the mandible, and sleep-disordered breathing
    Jee Hyun Kim
    Dankook University College of Medicine, Cheonan, South Korea
    Sleep Breath 15:185-93. 2011
    ..aims to use clinical scales in a standardized fashion in evaluating the frequency of a high and narrow hard palate and/or small and retroplaced mandible in children with polysomnographically demonstrated sleep-disordered breathing (SDB).
  98. doi Long-term survival of composite hemiface/mandible/tongue allografts correlates with multilineage chimerism development in the lymphoid and myeloid compartments of recipients
    Yalcin Kulahci
    Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA
    Transplantation 90:843-52. 2010
    ..We have assessed role of different components of the hemiface/mandible/tongue allograft on induction and maintenance of donor-specific chimerism, in correlation with allograft survival.
  99. ncbi The root and root canal morphology of the human mandibular first premolar: a literature review
    Blaine M Cleghorn
    Department of Dental Clinical Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
    J Endod 33:509-16. 2007
    ..The root and root canal morphology of this tooth can be complex and requires careful evaluation prior to root canal therapy...
  100. pmc Epigenetic effects on the mouse mandible: common features and discrepancies in remodeling due to muscular dystrophy and response to food consistency
    Sabrina Renaud
    Paléoenvironnements et Paléobiosphère, UMR5125, CNRS, Universite Lyon 1, Campus de la Doua, Villeurbanne, France
    BMC Evol Biol 10:28. 2010
    ..The mouse mandible is particularly prone to such plastic variations because bone remodeling occurs late in postnatal ontogeny, in ..
  101. ncbi Micromechanics-based conversion of CT data into anisotropic elasticity tensors, applied to FE simulations of a mandible
    Christian Hellmich
    Vienna University of Technology TU Wien, A 1040, Vienna, Austria
    Ann Biomed Eng 36:108-22. 2008
    ..Corresponding whole-organ Finite Element (FE) analyses of a partially edentulous human mandible characterized by atrophy of the alveolar ridge show that volumetric strain concentrations/peaks within the organ ..

Research Grants67

  1. MECHANICAL ENVIRONMENT IN MANDIBULAR DISTRACTION
    Susan Herring; Fiscal Year: 2006
    ..Although DO has been used on the mandible for only a decade, the technique is already supplanting more traditional orthognathic procedures, especially for ..
  2. A 3-D Interactive Atlas of the Maxilla, Mandible & TMJ
    William Brown; Fiscal Year: 2006
    ..The first Aim is to define the anatomy, vascularity, innervation, muscle, and bone of the maxilla, mandible, TMJ and surrounding tissue. We will use data collection methods perfected during the Phase I grant...
  3. A Novel Implant-based Approach for Treating Retrognathic Hyperdivergent Patients
    Peter Buschang; Fiscal Year: 2007
    ..The first aim is to determine whether MSI's can be successfully used to rotate the mandible, advance the chin, and improve lower facial profile...
  4. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Specifically, mutants from line 04/014 develop a short mandible, a hypoplastic or absent hyoid, and rudimentary neck cartilages...
  5. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
    ..We have used the model of cherubism, a rare disorder characterized by giant-cell bone resorptive tumors of the mandible and maxilla, to explore novel pathways that regulate osteoclast development and function...
  6. MOLECULAR MECHANISMS FOR EXTRACELLULAR PH CONTROL DURING AMELOGENESIS
    MICHAEL LANSDELL PAINE; Fiscal Year: 2013
    ..SA 3 will characterize the forming enamel from AE2-null and NBCe1-null mice using hemi-mandible explants...
  7. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ..vivo bioluminescence imaging and micro- computed tomography, followed by histology of tongue, floor of mouth, and mandible. To define in vivo interaction of La and MMP-2 mRNA we will perform RIP assays of oral tumor tissue...
  8. Translational Optimization of Bone Regeneration in the Irradiated Mandible
    Steven R Buchman; Fiscal Year: 2013
    ..is that the deleterious effects of XRT on bone formation can be mitigated to allow successful regeneration of the mandible and restore the capacity for normal bone healing...
  9. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..and heterozygous for Spry2 have supernumerary incisors in the maxilla and remarkable tusk-like incisors in the mandible. Embryos that are null for two Sprouty genes also develop supernumerary incisors, although the morphology of ..
  10. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..Previously, it was thought that PRS occurred as a result of environmental factors that restrict outgrowth of the mandible, but it is now quite clear that this sequence also has an undefined genetic component(s)...
  11. Oral Mucosa in Bisphosphonate-associated Osteonecrosis of the Jaw
    Kotaro Sena; Fiscal Year: 2010
    ..However, it is unclear why these lesions present with loss of the oral mucosal covering of the mandible or maxilla as the primary clinical feature...
  12. Treatment of Osteoradionecrosis with Bone Marrow Stromal Cells
    Sunday O Akintoye; Fiscal Year: 2010
    ..investigate site-specific distinctive osteogenic properties and radiosensitivity of human BMSC of the maxilla and mandible (neural crest origin) and ilium (mesodermal origin)...
  13. Intracellular trafficking of Bisphosphonates in bone mesenchymal Stem Cells
    Sunday O Akintoye; Fiscal Year: 2013
    ..that orofacial bone marrow stromal cells or bone mesenchymal stem cells (BMSCs) from neural crest-derived maxilla/mandible (OFMSCs) are highly proliferative with long population doublings relative to those of mesoderm-derived iliac bone ..
  14. NOVEL THERAPEUTICS FOR POSTMENOPAUSAL OSTEOPOROSIS
    Ping Men; Fiscal Year: 2012
    ..g. femur, humerus, mandible, tibia and vertebra) in the animals will be collected after treatment and the treatment efficacy will be ..
  15. Bisphosphonate-related osteonecrosis of the jaw: Bridging the clinical-preclinica
    Matthew R Allen; Fiscal Year: 2010
    ..In a preclinical model our laboratory has shown the existence of necrotic bone matrix within the mandible (as opposed to the presence of exposed bone as seen clinically with BRONJ) following bisphosphonate-treatment...
  16. Improved manufacture of bone transport plates
    TIMOTHY MULONE; Fiscal Year: 2009
    ..Benign tumors of the mandible may also require segmental bone resection due to high incidence of local recurrence after simple curettage or ..
  17. Botulinum toxin in muscles of mastication
    Susan W Herring; Fiscal Year: 2012
    ..The proposed research is a systematic examination of the effects of BoNT/A on the masseter muscle and the mandible, using two accepted animal models of human masticatory function, rabbit and pig...
  18. Bone Turnover Effects on Bisphosphonate Concentration in the Mandible
    Kenneth M Kozloff; Fiscal Year: 2012
    ..High local bisphosphonate concentration in the mandible due to enhanced drug delivery or enhanced drug retention may amplify anti- osteoclastic effects of ..
  19. Bmp-signaling in craniofacial development
    JAMES FRANCIS MARTIN; Fiscal Year: 2012
    ..In the forming mandible, signaling between a specified branchial arch ectoderm and a plastic mesenchyme is thought to regulate mandibular ..
  20. A 3-D Interactive Atlas of the Human Skull
    Kevin N Montgomery; Fiscal Year: 2010
    ..The first program will focus on human growth, development patterns, measurements, and aging of the maxilla and mandible. As the skull library matures we will include important skulls from several other collections...
  21. Genetic basis of the neural crest deficit in Down syndrome mice
    Randall J Roper; Fiscal Year: 2010
    ..and exhibit DS-like abnormalities of the skull including brachycephaly, hypomorphic midface, and small dysmorphic mandible. Because many tissues affected in DS, including craniofacial skeleton, have a neural crest (NC) component, it has ..
  22. Craniofacial Gene Discovery in Mice
    Leah Rae B Donahue; Fiscal Year: 2010
    ..a belly spot, partial or complete anophthalmia, facial clefting, holoproencephaly, and severely underdeveloped mandible and facial structures;and c) Lse, a semi-dominant mutation causing low set ears, skull and eye abnormalities...
  23. Biomimetic Scaffold Delivering Osteogenic Molecules for Alveolar Bone Engineering
    Min Lee; Fiscal Year: 2013
    ..and malignant neoplasms are devastating complications often leading to the resection of large segments of the mandible. Various osteoinductive growth factor-based therapies have been developed in an attempt to find an effective and ..
  24. Matrix-assisted Craniofacial Bone Regeneration
    Mitsuo Yamauchi; Fiscal Year: 2012
    ..vitro, and in Aim 2, we will test if the BGN/effector domain can promote bone formation in vivo employing a rat mandible defect model...
  25. CFM: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK)
    MATTHEW LOUIS SPELTZ; Fiscal Year: 2013
    ..This condition is frequently associated with malformations of the outer, inner and middle ear, mandible, soft tissue, and facial nerve, resulting in varying degrees of facial asymmetry...
  26. Randomized controlled clinical trial of botulinum toxin for myofascial TMJD pain
    Karen G Raphael; Fiscal Year: 2012
    ..and elicited pain intensity, (2) masticatory muscle function, and (3) density, volume and morphology of the mandible and maxilla in regions supporting the posterior teeth, as well as the mandibular condyle...
  27. Role of the novel regulator lbh in neural crest and craniofacial development
    KARA POWDER; Fiscal Year: 2013
    ..and evolution of lbh using biologically relevant alleles of lbh isolated from cichlids with differing mandible lengths...
  28. Osteogenic Enrichment of Adipose Derived Stromal Cells
    Michael T Longaker; Fiscal Year: 2013
    ..In small pilot studies, defects of the cranium, maxilla, and mandible have been either healed or enabled to heal faster with the use of hASCs...
  29. Diabetic Fracture Healing
    Dana T Graves; Fiscal Year: 2013
    ..Furthermore, diabetes interferes with fracture repair of the mandible and long bones...
  30. Modeling of Hyperparathyroidism-Jaw Tumor Syndrome by Targeted Deletion of Hrpt2
    Jessica Costa; Fiscal Year: 2012
    ..individuals to the development of one or more benign or malignant parathyroid tumors, ossifying fibromas of the mandible and/or maxilla, benign or malignant uterine tumors and, less commonly, cystic kidney lesions, renal hamartomas or ..
  31. PREVENTION OF X-RAY INDUCED MALFORMATIONS
    MARVIN SODICOFF; Fiscal Year: 1990
    ..Defects typically affect the head resulting in craniofacial abnormalities e.g., shape, shortening of the mandible and maxilla, cleft lip, palate, and face with defects of eye and ear development...
  32. EVALUATION OF OVERDENTURE UTILIZING IMPLANT RETENTION
    David Burns; Fiscal Year: 1990
    ..modality providing magnetic retention between the mandibular complete denture and implants placed within the mandible, shows promise as a predictable and cost effective method of increasing denture retention...
  33. Bioactive Peptide Coatings for Synthetic Bone Grafts in Dental Applications
    HANNE GRON; Fiscal Year: 2007
    ..Finally, a rat mandible defect model will be used to investigate the ability of peptide coatings to increase bone formation at lower ..
  34. INTERLAKEN SERIES 3000 AXIAL-TORSIONAL MATERIALS TESTING
    Wilson Hayes; Fiscal Year: 1992
    ..strength of the femurs and the extent of osteoporotic changes would be compared to similar relationships for the mandible. These data would be applied to understanding the importance of osteoporotic changes in the mandible; 5) The ..
  35. BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATION
    JEFFREY GORSKI; Fiscal Year: 2003
    ..remnants in the primary spongiosa, while all or parts of the frontal, parietal, occipital, temporal, maxilla, and mandible bones of the craniofacial system form and remain as primary bone...
  36. Mandibular Bone transport Reconstruction Plate
    LYNNE OPPERMAN; Fiscal Year: 2006
    ..However, the newly formed mandible is retruded due to soft tissue pressure and normal curvature of the mandible is not achieved...
  37. Novel mandibular bone transport reconstruction plate
    LYNNE OPPERMAN; Fiscal Year: 2003
    ..Nevertheless, the newly formed mandible is retruded due to soft tissue pressure and normal curvature of the mandible is not achieved...
  38. Clinical Investigation of Mandibular Implant Overdenture
    David Burns; Fiscal Year: 2005
    ..Each subject has four dental implants placed into the anterior mandible and new dentures are fabricated...
  39. IN VIVO MECHANISMS OF LOCAL STATIN-INDUCED BONE
    Richard Reinhardt; Fiscal Year: 2004
    ..An in vivo rat bilateral mandible model will be used which allows active drug (simvastatin) to be delivered supraperiosteally at varying doses in a ..
  40. EFFECTS OF AGING AND EXERCISE ON BONE MASS
    Coralease Ruff; Fiscal Year: 1992
    ..Using these techniques, bone mineral content of the distal and midshaft femur, lumbar vertebrae, and mandible-maxillae, and cortical geometry of the midshaft femur will be determined 12 months prior to treatment, at the ..
  41. A 3-D Interactive Atlas of the Human Mandible and TMJ
    William Brown; Fiscal Year: 2003
    ..This project will focus on the human mandible, the temporomandibular joint (TMJ) and the associated soft tissues...
  42. DETECTION OF OSTEOPOROSIS USING DENTAL RADIOGRAPHS
    KARIN SOUTHARD; Fiscal Year: 1992
    ..derive the optimal set of image features for detecting a minimal loss of bone (for each region of the maxilla and mandible) and for accurately estimating the degree of bone density loss from a longitudinal series of radiographs...
  43. ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    Caroline Damsky; Fiscal Year: 1999
    ..to determine how proteinases and their inhibitors contribute to the differentiation and patterning of the mandible. Two pilot projects address the mechanism of interaction of a periodontal pathogen with extracellular matrix, and ..
  44. Dental Radiographic Predictors of Osteoporotic Fracture
    STUART WHITE; Fiscal Year: 2004
    ..We have found such changes in the maxilla and mandible of osteoporotic patients...
  45. DETERMINATION OF OPTIMAL RESOURCES & CARE FOR CHILDREN WITH CRANIOFACIAL DEFECTS
    Whitney Burnett; Fiscal Year: 2007
    ..study on the early correction of the mandibular hypoplasia and its affect on the inherent growth potential of the mandible. This study will clarify the optimum timing of this dramatic reconstructive procedure...
  46. IMPROVING TREATMENT OUTCOMES FOR PATIENTS WITH FACIAL DEFORMITY USING 3D IMAGING
    LUCIA H CEVIDANES; Fiscal Year: 2010
    ..In the 3D characterization, the surface distances between the 3-D models of the "affected" side of the mandible and the reflected mirror image of the "unaffected" side will be used to anatomically locate and estimate the ..
  47. MUSCULAR DISORDERS IN CRANIOFACIAL MALFORMATIONS
    Karin Vargervik; Fiscal Year: 1990
    ..At the present time, any desired increase in length of an underdeveloped mandible can be achieved with long- term stable results...
  48. FUNCTIONAL EFFECTS OF MASTICATORY MUSCLE ALTERATION
    Paul Dechow; Fiscal Year: 1992
    ..muscle following myectomy of the temporalis muscle; (4) reduced function resulting from immobilization of the mandible or an altered diet; and (5) trauma resulting from myotomy of the masseter muscle...
  49. ROLE OF H-2 IN ORAL-FACIAL DEVELOPMENT
    Tina Jaskoll; Fiscal Year: 1990
    ..including timing of the first cleavage division, steroid receptor number and responsiveness, morphogenesis of the mandible and other facial structures and overall fetal growth and survival...
  50. Continuous, Automated, Mandibular Distractor
    JOHN MAGILL; Fiscal Year: 2003
    ..of Oral and Maxillofacial Surgery to develop an innovative device for distraction osteogenesis (DO) of the mandible. DO taps the bone regeneration ability of the body to fill a bone gap that is gradually expanded with a ..
  51. REGULATION OF JAW MOVEMENTS
    Lee Robertson; Fiscal Year: 1993
    ..The three-dimensional movements of the mandible will be recorded, which will provide data on the position, velocity, and trajectory of the jaw during all tasks...
  52. ENHANCEMENT OF OSSEOINTEGRATION USING RESONANT EM FIELDS
    ALLAN WEINSTEIN; Fiscal Year: 1990
    ..While it would be preferable to utilize an edentulous mandible model, given the time and budgeting constraints the transcortical model is more appropriate for demonstration of ..
  53. Genetics of Maxillary/Mandibular Discrepancies
    Linda Krebs; Fiscal Year: 2005
    ..based dentofacial dysmorphologies can result from discrepancies in the size, shape and/or position of the mandible and/or the maxilla...
  54. The Role of Osteopontin in Cancer Progression and Bone Metastasis
    BRIAN WILSON ROBERTSON; Fiscal Year: 2010
    ..chosen as a model system due to there ability to express OPN and metastasize to osseous structures, including the mandible. The down stream effects of the engagement of OPN and its cell surface receptors will focus on the cell signaling ..
  55. EFFECT OF MANDIBULAR POSITION ON CRANIOSKELETAL GROWTH
    Arthur Miller; Fiscal Year: 1990
    ..The purpose is to determine the effect of the asymmetric rest position on the growth of the cranioskeleton and mandible, the remodeling of this system and the complementary changes in the neuromuscular system...
  56. PATTERNS OF DENTOCRANIOFACIAL GROWTH AND MATURATION
    ALEXANDER ROCHE; Fiscal Year: 1980
    Dentocraniofacial variables, with emphasis on the cranial base, cranial vault, maxilla and mandible will be studied in normal children...
  57. LATERAL PTERYGOID MUSCLE FUNCTION/CONDYLAR GROWTH
    James Sciote; Fiscal Year: 1991
    ..occur within the lateral pterygoid and superficial masseter muscles in response to functional protrusion of the mandible. Laboratory rats will be used as experimental animals...
  58. Animal models for TMJ research: Functional 3-D loading
    KATHERINE RAFFERTY; Fiscal Year: 2003
    ..the proposed study we will explore these differences and similarities by measuring three-dimensional loads on the mandible during masticatory function in pigs and sheep...
  59. DISTRACTION OSTEOGENESIS--ENDOGENOUS TISSUE ENGINEERING
    Michael Longaker; Fiscal Year: 2002
    ..almost nothing is known about the cellular, molecular or biomechanical mechanisms that regulate DO in the mandible. The central hypothesis to be tested in this proposal is that the creation of newly engineered bone generated by ..
  60. INVESTIGATION OF THE RECEPTOR FOR OSTEOCALCIN
    PATRICIA MACCHIARULO; Fiscal Year: 1991
    ..the balance between bone formation and bone resorption within the alveolar processes of the maxilla and the mandible. The primary cells involved in the development and metabolism of bone are the osteoblast and the osteoclast...
  61. BIOCHEMICAL INFLUENCES ON CONDYLAR CARTILAGE GROWTH
    Robert Hinton; Fiscal Year: 1990
    It has been well established that the growth rate of the condylar cartilage of the mandible can be altered in response to changes in its biomechanical environment...
  62. CROSS - SECTIONAL IMAGING OF THE MANDIBLE
    Lars Hollender; Fiscal Year: 1993
    ..study to determine at which x-ray energies there is sufficient contrast between bone and soft tissue for the mandible to be considered a binary object. Aim II...
  63. DESIGNED SCAFFOLD ARCHITECTURE AFFECTS BONE REGENERATION
    Scott Hollister; Fiscal Year: 2003
    ..into how scaffold design influences vascularization, tissue ingrowth, and tissue function in a minipig mandible model...
  64. MANDIBULAR BONE AUGMENTATION BY PROSTAGLANDIN E1
    SANDY MARKS; Fiscal Year: 1992
    ..skeletal integration of this newly formed bone by following bone turnover through two remodeling cycles in this mandible. In addition, we shall measure the local tissue concentration of PGE and its metabolites at mineralized and soft ..
  65. Continuous, Automated, Mandibular Distraction Device
    JOHN MAGILL; Fiscal Year: 2006
    ..proposes to continue development of an innovative device for performing distraction osteogenesis (DO) of the mandible. The concept under development uses miniature hydraulics in a fully buried actuator capable of producing linear ..
  66. PROSPECTIVE EVALUATION OF IMPLANT SUPPORTED BRIDGES
    Michael Block; Fiscal Year: 2000
    ..Each patient received a one two-staged hydroxyapatite-coated implant on each side of the mandible in the first molar area. A bridge was attached to the first mandibular premolar and the hydroxyapatite implant...
  67. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2003
    ..Oral devices worn during sleep have been developed to maintain pharyngeal airway patency by moving the mandible and attached pharyngeal tissues forward...