choroid

Summary

Summary: The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.

Top Publications

  1. ncbi A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes
    Ron Margolis
    Vitreous Retina Macula Consultants of New York, New York, New York 10022, USA
    Am J Ophthalmol 147:811-5. 2009
  2. ncbi Choroidal thickness in healthy Japanese subjects
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:2173-6. 2010
  3. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
  4. ncbi Enhanced depth imaging spectral-domain optical coherence tomography
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York, LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 146:496-500. 2008
  5. ncbi Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy
    Yutaka Imamura
    Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA
    Retina 29:1469-73. 2009
  6. ncbi Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
    Song Ee Chung
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 118:840-5. 2011
  7. ncbi Subfoveal choroidal thickness after treatment of central serous chorioretinopathy
    Ichiro Maruko
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Ophthalmology 117:1792-9. 2010
  8. pmc Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography
    Varsha Manjunath
    New England Eye Center, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Ophthalmol 150:325-329.e1. 2010
  9. ncbi Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid
    Boy Braaf
    Rotterdam Ophthalmic Institute, Schiedamse Vest 160, 3011 BH Rotterdam, The Netherlands
    Opt Express 19:20886-903. 2011
  10. ncbi Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes
    Takamitsu Fujiwara
    The Vitreous, Retina, Macula Consultants of New York and LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 148:445-50. 2009

Detail Information

Publications306 found, 100 shown here

  1. ncbi A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes
    Ron Margolis
    Vitreous Retina Macula Consultants of New York, New York, New York 10022, USA
    Am J Ophthalmol 147:811-5. 2009
    ..To measure macular choroidal thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate the association of choroidal thickness and age...
  2. ncbi Choroidal thickness in healthy Japanese subjects
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Invest Ophthalmol Vis Sci 51:2173-6. 2010
    ..20) and inferior (P = 0.17) choroidal thickness. The temporal choroid was significantly (P < 0...
  3. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  4. ncbi Enhanced depth imaging spectral-domain optical coherence tomography
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York, LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 146:496-500. 2008
    To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images.
  5. ncbi Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy
    Yutaka Imamura
    Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA
    Retina 29:1469-73. 2009
    ..The purpose of the study was to evaluate the choroidal thickness in patients with central serous chorioretinopathy, a disease attributed to increased choroidal vascular hyperpermeability...
  6. ncbi Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration
    Song Ee Chung
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ophthalmology 118:840-5. 2011
    ..To compare choroidal thickness between eyes with polypoidal choroidal vasculopathy (PCV) and eyes with age-related macular degeneration (AMD)...
  7. ncbi Subfoveal choroidal thickness after treatment of central serous chorioretinopathy
    Ichiro Maruko
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Ophthalmology 117:1792-9. 2010
    ..To evaluate the subfoveal choroidal thickness after treatment of central serous chorioretinopathy (CSC) visualized by enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) and indocyanine green angiography (ICGA)...
  8. pmc Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography
    Varsha Manjunath
    New England Eye Center, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Ophthalmol 150:325-329.e1. 2010
    ..To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT)...
  9. ncbi Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid
    Boy Braaf
    Rotterdam Ophthalmic Institute, Schiedamse Vest 160, 3011 BH Rotterdam, The Netherlands
    Opt Express 19:20886-903. 2011
    ..used for the removal of fixed-pattern noise artifacts and for phase-resolved blood flow measurements in the human choroid. The system performed close to the shot-noise limit (<1dB) with a sensitivity of 99.1 dB for a 1...
  10. ncbi Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes
    Takamitsu Fujiwara
    The Vitreous, Retina, Macula Consultants of New York and LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 148:445-50. 2009
    ..To measure macular choroidal thickness (CT) in highly myopic eyes using enhanced depth imaging optical coherence tomography (OCT)...
  11. ncbi Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka Japan
    Invest Ophthalmol Vis Sci 50:3876-80. 2009
    Morphologic changes in the retina and choroid are closely related with high myopia-related diseases. This study was conducted to evaluate the morphologic characteristics of normal highly myopic eyes.
  12. pmc Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97237, USA
    Opt Lett 35:1467-9. 2010
    We demonstrate the depth-resolved and detailed ocular perfusion maps within retina and choroid can be obtained from an ultrahigh sensitive optical microangiography (OMAG)...
  13. pmc Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy
    Luiz H Lima
    The Vitreous, Retina, Macula Consultants of New York and the LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, USA
    Ophthalmology 117:1567-70. 2010
    ..To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV)...
  14. ncbi Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease?
    Augustinus Laude
    Princess Alexandra Eye Pavilion, NHS Lothian, United Kingdom
    Prog Retin Eye Res 29:19-29. 2010
    ..g. smoking). Such information could further assist clinicians involved in the care of elderly patients with these conditions...
  15. ncbi Repeatability of manual subfoveal choroidal thickness measurements in healthy subjects using the technique of enhanced depth imaging optical coherence tomography
    Waheeda Rahman
    Moorfields Eye Hospital, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:2267-71. 2011
    ..The aim of this study was to investigate the repeatability of manual measurements of choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using the enhanced depth imaging (EDI) technique...
  16. ncbi Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography
    Colin S Tan
    Doheny Eye Institute, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 53:261-6. 2012
    ..To describe the pattern and magnitude of diurnal variation of choroidal thickness (CT), its relation to systemic and ocular factors, and to determine the intervisit reproducibility of diurnal patterns...
  17. pmc Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients
    Eugenio A Maul
    The Glaucoma Service and Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute at Johns Hopkins University, USA
    Ophthalmology 118:1571-9. 2011
    ..To measure choroidal thickness and to determine parameters associated with it...
  18. ncbi Age-related choroidal atrophy
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York and the LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 147:801-10. 2009
    ..To report the clinical characteristics of a newly defined entity, age-related choroidal atrophy...
  19. pmc Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease
    Joanna Kur
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Prog Retin Eye Res 31:377-406. 2012
    We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease...
  20. pmc The association of age-related maculopathy susceptibility 2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Mol Vis 17:977-82. 2011
    ....
  21. ncbi Reduced foveolar choroidal blood flow in eyes with increasing AMD severity
    Juan E Grunwald
    Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 46:1033-8. 2005
    ..To explore further the choroidal circulatory changes in patients with AMD, the relationship between ChBFlow and fundus features associated with increased risk of choroidal neovascularization (CNV) were investigated...
  22. pmc Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate
    Ruikang K Wang
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Opt 16:050503. 2011
    ..OCT system, combined with optical microangiography that operates at a 92-kHz line scan rate for multifunctional imaging of the human eye, delivering the volumetric imaging of microstructure and microvasculature within retina and choroid.
  23. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010
    ..Third, we identify and characterize the local complement system in the RPE-choroid complex - thus adding a new dimension of biological complexity to the role of the complement system in ocular ..
  24. ncbi Clinical characteristics of exudative age-related macular degeneration in Japanese patients
    Ichiro Maruko
    Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Am J Ophthalmol 144:15-22. 2007
    ..To clarify the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients...
  25. ncbi Lack of association with PEDF Met72Thr variant in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese population
    Kunfang Wu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Curr Eye Res 37:68-72. 2012
    ....
  26. pmc In vivo human choroidal thickness measurements: evidence for diurnal fluctuations
    Jamin S Brown
    Kresge Eye Institute, Wayne State University, Detroit, Michigan 48236, USA
    Invest Ophthalmol Vis Sci 50:5-12. 2009
    The authors applied partial coherence interferometry (PCI) to estimate the thickness of the human choroid in vivo and to learn whether it fluctuates during the day.
  27. ncbi Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics
    Kenichiro Sho
    Department of Ophthalmology, Kansai Medical University, Fumizono cho, Moriguchi, Osaka, Japan
    Arch Ophthalmol 121:1392-6. 2003
    ..To clarify the incidence, demographic features, and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  28. ncbi Immune cells in the human choroid
    M K Ezzat
    Department of Ophthalmology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN 55905, USA
    Br J Ophthalmol 92:976-80. 2008
    To characterise the leucocytes in human macular choroid with and without drusen, and in eyes with advanced age-related macular degeneration (AMD) with fibrovascular scarring (FVS).
  29. ncbi Clinicopathologic findings in polypoidal choroidal vasculopathy
    Hiroyuki Nakashizuka
    Department of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:4729-37. 2008
    ..To elucidate the pathogenic mechanism of polypoidal choroidal vasculopathy (PCV) based on histopathologic findings...
  30. ncbi Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy
    Kelvin Y Lee
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:2613-9. 2008
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  31. ncbi Subtype lesions of neovascular age-related macular degeneration in Chinese patients
    Yan Liu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou 510060, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 245:1441-5. 2007
    ..To identify the subtype frequency and clinical features of neovascular age-related macular degeneration (AMD) in Chinese patients...
  32. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ....
  33. ncbi Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a 30-month multicenter study in Hyogo, Japan
    Shigeru Honda
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, and Department of Ophthalmology, Kobe City General Hospital, Kobe, Japan
    Jpn J Ophthalmol 53:593-7. 2009
    ..To evaluate the long-term effects of photodynamic therapy (PDT) on different phenotypes of age-related macular degeneration (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  34. pmc Doppler variance imaging for three-dimensional retina and choroid angiography
    Lingfeng Yu
    University of California, Irvine, Irvine Beckman Laser Institute, Department of Biomedical Engineering, Irvine, California 92612, USA
    J Biomed Opt 15:016029. 2010
    ..tomography velocity and structural images, we use the variance of blood flow velocity to map the retina and choroid vessels...
  35. pmc DNA methylation is associated with altered gene expression in AMD
    Allan Hunter
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 53:2089-105. 2012
    ..To assess the potential contribution of epigenetic regulation of antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, a tissue-specific genetic modulation that affects gene expression...
  36. ncbi Reproducibility of retinal and choroidal thickness measurements in enhanced depth imaging and high-penetration optical coherence tomography
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:5536-40. 2011
    Two optical coherence tomography (OCT) modalities can visualize the choroid: high-penetration OCT (HP-OCT) using a long wavelength, and enhanced depth imaging technique using Heidelberg OCT (EDI-OCT)...
  37. ncbi Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects
    Shinichi Usui
    National Hospital Organization, Osaka National Hospital, Osaka, Japan
    Invest Ophthalmol Vis Sci 53:2300-7. 2012
    ..To investigate circadian changes in subfoveal choroidal thickness (SFCT) and the relation to systemic factors in healthy subjects...
  38. ncbi Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography
    Jonathan Yeoh
    Moorfields Eye Hospital, City Road, EC1V2PD, London, UK
    Graefes Arch Clin Exp Ophthalmol 248:1719-28. 2010
    ..Associations between choroidal change and genotype, visual acuity and results of retinal electrophysiology are also explored...
  39. ncbi Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy
    Hideki Koizumi
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 0841, Japan
    Graefes Arch Clin Exp Ophthalmol 249:1123-8. 2011
    ..To investigate the subfoveal choroidal thickness in eyes with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), using enhanced depth imaging optical coherence tomography...
  40. ncbi Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Takashi Ueta
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Ophthalmology 116:2400-6. 2009
    ..To compare background factors of the 2 most dominant subtypes of exudative age-related macular degeneration (AMD) in the Japanese population: typical AMD and polypoidal choroidal vasculopathy (PCV)...
  41. pmc Analysis of normal peripapillary choroidal thickness via spectral domain optical coherence tomography
    Joseph Ho
    New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA
    Ophthalmology 118:2001-7. 2011
    ..To analyze the normal peripapillary choroidal thickness utilizing a commercial spectral domain optical coherence tomography (OCT) device and determine the intergrader reproducibility of this method...
  42. ncbi The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages
    Falk Schroedl
    Department of Anatomy I, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 49:5222-9. 2008
    ..To date, there is no report on its expression in the posterior human uvea. The purpose of this study was to investigate the expression of LYVE-1 in normal human choroids...
  43. ncbi Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics
    Ranjay Chakraborty
    Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
    Invest Ophthalmol Vis Sci 52:5121-9. 2011
    ..To investigate the pattern of diurnal variations in axial length (AL), choroidal thickness, intraocular pressure (IOP), and ocular biometrics over 2 consecutive days...
  44. ncbi Enhanced depth imaging optical coherence tomography of the choroid in idiopathic macular hole: A cross-sectional prospective study
    Michele Reibaldi
    Department of Ophthalmology, University of Catania, Italy
    Am J Ophthalmol 151:112-117.e2. 2011
    ..To determine the choroidal thickness in the macular area in patients with idiopathic macular hole in one eye and an unaffected fellow eye and in healthy controls...
  45. ncbi Advanced glycation end products induce choroidal endothelial cell proliferation, matrix metalloproteinase-2 and VEGF upregulation in vitro
    S Hoffmann
    Department of Ophthalmology, University of Leipzig, Liebigstrasse 10 14, 03411 Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 240:996-1002. 2002
    ..Furthermore, the effects of AGEs on expression of matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) by CECs were explored...
  46. pmc Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study
    A Okubo
    Department of Ophthalmology, Kagoshima University Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Br J Ophthalmol 86:1093-8. 2002
    ..To describe the clinical and histopathological findings in a patient with polypoidal choroidal vasculopathy...
  47. ncbi Pathological features of surgically excised polypoidal choroidal vasculopathy membranes
    Sachiko Kuroiwa
    Shinshu University School of Medicine, Matsumoto, Japan
    Clin Experiment Ophthalmol 32:297-302. 2004
    ..This study indicates that large choroidal arterioles and venules can be found in excised specimens from patients with polypoidal choroidal vasculopathy and arteriosclerosis is an important pathological feature...
  48. ncbi Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography
    Joshua R Ehrlich
    Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USA
    Exp Eye Res 92:189-94. 2011
    ..We conclude that eyes with POAG did not demonstrate reduced CT nor was there a correlation between RNFL and CT maps. This study does not support the use of CT assessment in glaucoma diagnosis or management...
  49. ncbi Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy
    Norimoto Gotoh
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Jpn J Ophthalmol 54:609-14. 2010
    ..2 kb, were genotyped. Associations were tested using single-SNP and haplotype analyses...
  50. ncbi Retinal pigment epithelium (RPE)-choroid graft translocation in the treatment of an RPE tear: preliminary results
    K Maaijwee
    The Rotterdam Eye Hospital, Schiedamse Vest 180, 3011 BH Rotterdam, The Netherlands
    Br J Ophthalmol 92:526-9. 2008
    To investigate whether retinal pigment epithelium (RPE)-choroid translocation would be a suitable treatment for RPE tears, which have a poor prognosis and are encountered more often since the introduction of anti-(vascular endothelial ..
  51. ncbi Role of photodynamic therapy in polypoidal choroidal vasculopathy
    Eriko Akaza
    Department of Ophthalmology, Surugadai Hospital of Nihon University, Kanda, Tokyo, Japan
    Jpn J Ophthalmol 51:270-7. 2007
    ..To determine the efficacy of photodynamic therapy (PDT) with verteporfin for polypoidal choroidal vasculopathy (PCV)...
  52. ncbi Three-year follow-up results of photodynamic therapy for polypoidal choroidal vasculopathy
    Eriko Akaza
    Department of Ophthalmology, Nihon University Surugadai Hospital, Tokyo, Japan
    Jpn J Ophthalmol 55:39-44. 2011
    ..To evaluate the visual outcomes and changes in abnormal vascular networks and polypoidal lesions of polypoidal choroidal vasculopathy (PCV) 3 years after photodynamic therapy (PDT)...
  53. pmc Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
    John W Crabb
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, and Department of Chemistry, Case Western Reserve University, OH 44195, USA
    Proc Natl Acad Sci U S A 99:14682-7. 2002
    ..These data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation...
  54. ncbi Frequency of choroidal abnormalities in neurofibromatosis type 1
    T Yasunari
    Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan
    Lancet 356:988-92. 2000
    ..a scanning laser ophthalmoscope (SLO) and indocyanine-green fundus angiography has allowed examination of the choroid. We studied choroidal abnormalities in patients with neurofibromatosis 1 and compared their frequency with that ..
  55. ncbi Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy
    Hideo Nakanishi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:6183-7. 2010
    ....
  56. ncbi One-year results of three monthly ranibizumab injections and as-needed reinjections for polypoidal choroidal vasculopathy in Japanese patients
    Taiichi Hikichi
    Ohtsuka Eye Hospital, Sapporo, Japan
    Am J Ophthalmol 154:117-124.e1. 2012
    ..To investigate the 1-year outcomes of monthly intravitreal injections of ranibizumab for 3 months followed by an as-needed reinjection schedule to treat polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  57. pmc Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid
    P T Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 5060, USA
    Proc Natl Acad Sci U S A 103:17456-61. 2006
    ..proteins, and abundant serum proteins in the retinal pigmented epithelium (RPE), Bruch's membrane, and choroid (RPE-choroid) in CFH homozygotes possessing either the "at-risk" 402HH or "normal" 402YY variants...
  58. ncbi Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy
    T Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Br J Ophthalmol 92:936-40. 2008
    ..To clarify vascular changes of polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT)...
  59. pmc Pharmacokinetics of pars plana intravitreal injections versus microcannula suprachoroidal injections of bevacizumab in a porcine model
    Timothy W Olsen
    Emory Eye Center, Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 52:4749-56. 2011
    ..To compare the pharmacokinetics and tissue response between intravitreal and microcannulation injections into the suprachoroidal space using bevacizumab...
  60. ncbi Polypoidal choroidal vasculopathy: natural history
    Masanobu Uyama
    Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
    Am J Ophthalmol 133:639-48. 2002
    ..The present study was performed to clarify the long-term natural history of polypoidal choroidal vasculopathy (PCV)...
  61. ncbi Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways
    Alexa Klettner
    Department of Ophthalmology, University of Kiel, Kiel, Germany
    Invest Ophthalmol Vis Sci 49:4523-7. 2008
    ..In this study, the authors compare these VEGF inhibitors directly regarding their efficiency to neutralize VEGF in a quantifiable in vitro system...
  62. ncbi CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation
    Hisako Hayashi
    Department of Ophthalmology and Visual Sciences, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:5914-9. 2010
    ....
  63. ncbi Polypoidal choroidal vasculopathy in elderly Chinese patients
    Feng Wen
    Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, 510060 Guangzhou, PR China
    Graefes Arch Clin Exp Ophthalmol 242:625-9. 2004
    ..To investigate the frequency and clinical features of polypoidal choroidal vasculopathy (PCV) in a consecutive series of elderly Chinese patients...
  64. ncbi Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration
    Imran A Bhutto
    Department of Ophthalmology, The Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 9115, USA
    Exp Eye Res 82:99-110. 2006
    ..VEGF; an angiogenic factor) and pigment epithelium-derived factor (PEDF; an antiangiogenic factor) in aged human choroid and to determine if the localization or their relative levels changed in age-related macular degeneration (AMD)...
  65. pmc The multifunctional choroid
    Debora L Nickla
    Department of Biosciences, New England College of Optometry, Boston, MA 02115, USA
    Prog Retin Eye Res 29:144-68. 2010
    The choroid of the eye is primarily a vascular structure supplying the outer retina...
  66. ncbi Polypoidal choroidal vasculopathy: a review
    Yutaka Imamura
    The LuEster T Mertz Retinal Research Center, Manhattan Eye Ear and Throat Hospital, New York, New York, USA
    Surv Ophthalmol 55:501-15. 2010
    ..We emphasize multimodal ophthalmic imaging of these vessels, in particular fluorescein and indocyanine green angiography and optical coherence tomography...
  67. ncbi Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye
    Suzanne Einmahl
    Department of Pharmaceutical Technology and Biopharmaceutics, School of Pharmacy, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Invest Ophthalmol Vis Sci 43:1533-9. 2002
    ....
  68. ncbi Pharmacokinetics of intraocular drug delivery of Oregon green 488-labeled triamcinolone by subtenon injection using ocular fluorophotometry in rabbit eyes
    Sung Jin Lee
    Department of Ophthalmology, College of Medicine, Soonchunhyang University, Seoul, Korea
    Invest Ophthalmol Vis Sci 49:4506-14. 2008
    ..To evaluate the transscleral delivery of Oregon Green-labeled triamcinolone acetonide (OGTA) into the eye...
  69. ncbi Factors predictive of visual acuity outcomes 1 year after photodynamic therapy in Japanese patients with polypoidal choroidal vasculopathy
    Taiichi Hikichi
    Ohtsuka Eye Hospital, Sapporo, Japan
    Retina 31:857-65. 2011
    ..The purpose of this study was to determine the factors predictive of visual acuity (VA) outcomes 1 year after photodynamic therapy (PDT) for polypoidal choroidal vasculopathy...
  70. pmc Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography
    Varsha Manjunath
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, USA
    Am J Ophthalmol 152:663-8. 2011
    ..To understand the relationship between choroidal thickness and various disease factors in patients with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography...
  71. ncbi Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy
    Yumiko Kurashige
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Am J Ophthalmol 146:513-519. 2008
    ..To report on the two-year visual outcomes of indocyanine green angiography-guided photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) patients...
  72. ncbi Gender and estrogen supplementation increases severity of experimental choroidal neovascularization
    Diego G Espinosa-Heidmann
    Department of Ophthalmology, Bascom Palmer Eye Institute, William L McKnight Vision Research Center, The University of Miami School of Medicine, 1638 N W 10th Avenue, Miami, FL 33136, USA
    Exp Eye Res 80:413-23. 2005
    ..endothelial cell or vascular smooth muscle cell)...
  73. ncbi Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma
    Shinichi Usui
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Ophthalmol 153:10-6.e1. 2012
    ..To evaluate the choroidal thickness by high-penetration optical coherence tomography (OCT) using long wavelength in highly myopic normal-tension glaucoma (NTG)...
  74. ncbi Role of NO in choroidal blood flow regulation during isometric exercise in healthy humans
    Alexandra Luksch
    Department of Clinical Pharmacology, University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 44:734-9. 2003
    ..The hypothesis for the study was that inhibition of NOS may influence choroidal blood flow during isometric exercise...
  75. pmc Elastin-mediated choroidal endothelial cell migration: possible role in age-related macular degeneration
    Jessica M Skeie
    Center for Macular Degeneration, Department of Ophthalmology and Visual Science, University of Iowa, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 49:5574-80. 2008
    ..Altered elastin metabolism has been described in AMD, and the present study sought to determine the effects of elastin-derived peptides (EDPs) on choroidal EC migration and proliferation...
  76. ncbi Comparative assessment of photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a multicenter study in Hyogo prefecture, Japan
    Shigeru Honda
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmologica 223:333-8. 2009
    ..We aimed to evaluate the effects of photodynamic therapy (PDT) on different phenotypes of age-related macular degenerations (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  77. pmc Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration
    I A Bhutto
    Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, 21287 9115, USA
    Br J Ophthalmol 90:906-10. 2006
    ..To examine the immunolocalisation of stromal cell derived factor 1 (SDF-1) and its receptor CXCR4 in aged control human donor eyes and eyes with age related macular degeneration (AMD)...
  78. ncbi Polypoidal choroidal vasculopathy
    Antonio P Ciardella
    The LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA
    Surv Ophthalmol 49:25-37. 2004
    ....
  79. ncbi Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy
    Naoshi Kondo
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmology 116:304-10. 2009
    ..To investigate whether variants in the complement factor H (CFH) gene are associated with polypoidal choroidal vasculopathy (PCV)...
  80. ncbi Autologous retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: short-term follow-up
    Jan C van Meurs
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Am J Ophthalmol 136:688-95. 2003
    To evaluate the feasibilty of translocating autologous retinal pigment epithelium cells and choroid after the removal of a subfoveal choroidal neovascular membrane in patients with exudative age-related macular degeneration.
  81. pmc Opposite effects of glucagon and insulin on compensation for spectacle lenses in chicks
    Xiaoying Zhu
    Department of Biology, City College, CUNY, New York, New York 10031, USA
    Invest Ophthalmol Vis Sci 50:24-36. 2009
    ..Glucagon may signal the sign of defocus. Do insulin (or IGF-1) and glucagon act oppositely in controlling eye growth, as they do in metabolic pathways and in control of retinal neurogenesis?..
  82. ncbi Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina
    Robert F Mullins
    Center for Macular Degeneration, Department of Ophthalmology and Visual Science, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Mol Vis 12:224-35. 2006
    ....
  83. ncbi Recurrence of polypoidal choroidal vasculopathy after photodynamic therapy
    Kenji Yamashiro
    Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan
    Jpn J Ophthalmol 52:457-62. 2008
    ..To evaluate the recurrence of polypoidal lesions after photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV)...
  84. ncbi [Photodynamic therapy for choroidal neovascularisation due to choroidal coloboma in a 5 1/2-year-old child]
    J von Eicken
    Klinik fur Augenheilkunde, Dietrich Bonhoeffer Klinikum Neubrandenburg, Salvador Allende Strasse 30, 17036 Neubrandenburg
    Klin Monbl Augenheilkd 224:140-5. 2007
    ..We add the case of a 5 and a half-year-old child with choroidal neovascularisation due to choroidal coloboma. We treated this condition with PDT...
  85. pmc Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme
    Giuseppe Lupo
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 108:8698-703. 2011
    Retinoic acid receptor (RAR) signaling is required for morphogenesis of the ventral optic cup and closure of the choroid fissure, but the mechanisms by which this pathway regulates ventral eye development remain controversial and poorly ..
  86. ncbi Intravitreal bevacizumab injection in patients with choroidal neovascularization due to choroid rupture after blunt-head trauma
    Ozgur Artunay
    Department of Ophthalmology, Istanbul Science University, Istanbul, Turkey
    Int Ophthalmol 29:289-91. 2009
    ..To describe and report the effect of intravitreal bevacizumab (Avastin) as primary treatment for secondary choroidal neovascularization (CNV) after choroidal rupture due to blunt-head trauma...
  87. pmc Circadian regulation of the PERIOD 2::LUCIFERASE bioluminescence rhythm in the mouse retinal pigment epithelium-choroid
    Kenkichi Baba
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30130, USA
    Mol Vis 16:2605-11. 2010
    ..present study was to investigate Period 2 (Per2) mRNA levels in the mouse RPE in vivo, and to determine whether the cultured RPE-choroid from PERIOD 2::LUCIFERASE (PER2::LUC) knockin mice expresses a circadian rhythm in bioluminescence.
  88. ncbi Association of LOC387715 A69S genotype with visual prognosis after photodynamic therapy for polypoidal choroidal vasculopathy
    Yoichi Sakurada
    Department of Opthalmology, Faculty of Medicine, University of Yamanashi, Shimokato, Yamanashi, Japan
    Retina 30:1616-21. 2010
    ..To investigate whether there is an association of the LOC387715 A69S genotype with visual prognosis after photodynamic therapy in eyes with polypoidal choroidal vasculopathy (PCV)...
  89. ncbi Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration
    Jay C Erie
    Department of Ophthalmology Mayo Clinic, Rochester, Minnesota, USA
    Am J Ophthalmol 147:276-282.e1. 2009
    To measure zinc and copper levels in the retinal pigment epithelium (RPE) and choroid complex and in the neural retina in subjects with and without age-related macular degeneration (AMD).
  90. ncbi Photodynamic therapy for polypoidal choroidal vasculopathy: vaso-occlusive effect on the branching vascular network and origin of recurrence
    Won Ki Lee
    Department of Ophthalmology, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Jpn J Ophthalmol 52:108-15. 2008
    ..To determine whether photodynamic therapy (PDT) has a vaso-occlusive effect on the branching vascular network in polypoidal choroidal vasculopathy (PCV) and whether PDT can prevent future recurrence...
  91. ncbi Changes in choriocapillaris fenestration of rat eyes after intravitreal bevacizumab injection
    Yukiko Shimomura
    Department of Ophthalmology, Saga University Faculty of Medicine, 5 1 1, Nabeshima, Saga, 849 8501, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1089-94. 2009
    ..To examine the effects of anti-VEGF antibody (bevacizumab) on the number of fenestrations in rat choriocapillaris...
  92. ncbi ARMS2 (LOC387715) variants in Japanese patients with exudative age-related macular degeneration and polypoidal choroidal vasculopathy
    Norimoto Gotoh
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Ophthalmol 147:1037-41, 1041.e1-2. 2009
    ....
  93. ncbi Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration
    Fred K Chen
    Moorfields Eye Hospital, London, UK
    Clin Experiment Ophthalmol 37:275-85. 2009
    To describe the 2- to 4-year visual and microperimetry outcomes of autologous retinal pigment epithelium (RPE)-choroid graft in patients with neovascular age-related macular degeneration (AMD).
  94. ncbi Clinical features and follow-up results of pulsating polypoidal choroidal vasculopathy treated with photodynamic therapy
    Suk Ho Byeon
    Department of Ophthalmology, The Institute of Vision Research, College of Medicine, Yonsei University, Seoul, Korea
    Acta Ophthalmol 88:660-8. 2010
    ..To report on the clinical course of pulsating polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT)...
  95. ncbi Normal aging involves altered expression of growth factors in the rat choroid
    Jena J Steinle
    Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave, Suite 722A, Memphis, TN 38163, USA
    J Gerontol A Biol Sci Med Sci 63:135-40. 2008
    Normal aging of the choroid results in morphological and physiological changes. The growth factors that mediate these changes are unclear...
  96. ncbi LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population
    Naoshi Kondo
    Department of Organs Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Ophthalmol 144:608-12. 2007
    ....
  97. ncbi Tomographic features of branching vascular networks in polypoidal choroidal vasculopathy
    Taku Sato
    Department of Ophthalmology, Gunma University School of Medicine, 3 Showamachi, Maebashi 371 8511, Gunma, Japan
    Retina 27:589-94. 2007
    ..To identify the tomographic features of the branching vascular networks in patients with polypoidal choroidal vasculopathy (PCV)...
  98. ncbi Polypoidal choroidal vasculopathy with large vascular network
    Hisashi Tateiwa
    Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Graefes Arch Clin Exp Ophthalmol 240:354-61. 2002
    ..To report characteristics of polypoidal choroidal vasculopathy (PCV) of large vascular networks that expand across the retinal vascular arcade...
  99. ncbi Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid
    Sahng Yeon Kim
    The Wilmer Ophthalmological Institute, Department of Ophthalmology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287 9115, USA
    Exp Eye Res 77:433-45. 2003
    ..PEDF might play an important role in inhibiting angiogenesis and inducing the regression of sea fans. Progression of angiogenesis may be dependent on the ratio of PEDF/VEGF...
  100. ncbi Evaluation of the circulation in the retina, peripapillary choroid and optic disk in normal-tension glaucoma
    T Sugiyama
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan
    Ophthalmic Res 32:79-86. 2000
    ..blood flow from the densitometric and time curves of the fluorescein angiograms in the optic disk, peripapillary choroid, retinal artery and vein for each quadrant...
  101. ncbi Nitric oxide synthase-containing cells in the retina, pigmented epithelium, choroid, and sclera of the chick eye
    A J Fischer
    Lions Sight Centre and Department of Anatomy, The University of Calgary, Faculty of Medicine, Alberta, Canada
    J Comp Neurol 405:1-14. 1999
    ..and immunoreactive NOS were detected in axon bundles and innervation to vascular smooth muscle in the choroid, whereas stromal and endothelial cells in the choroid, scleral chondrocytes, and the retinal pigmented epithelium ..

Research Grants72

  1. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..Non-invasive in vivo bioimaging using functionalized quantum dots targeting CCR3 detected CNV within the mouse choroid that had not yet invaded the retina and was invisible to fluorescein angiography...
  2. Genetically testing interactions of ER and oxidative stresses in retinal disease
    Douglas Gould; Fiscal Year: 2013
    ..The RPE/Bruch's membrane/choroid complex is an important site of pathogenesis in several retinal diseases...
  3. Organic Cation Transporter PMAT: Physiological Function and Role in Drug Disposit
    Joanne Wang; Fiscal Year: 2013
    ..work strongly supports a role of PMAT in 5-HT signaling pathways and in OC transport at barrier tissues including choroid plexus that forms the blood- cerebrospinal fluid (CSF) barrier...
  4. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..suspended in the thermosensitive gel, using in vitro (ARPE-19 cell line) and ex vivo (isolated sclera and RPE-choroid-sclera) models (2) to synthesize ester-peptide (Valine-, Valine-Valine-, Glycine-Valine-, and Tyrosine-Valine-) ..
  5. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    ..2. Measure the thickness of each retinal layer, Bruch's membrane (BrM), and choroid across the macula and in comparison regions of peripheral retina. 3...
  6. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2013
    ..Since the CSF turns over several times per day, the CSF-choroid-plexus system is ideally suited for triggering rapid and spatially synchronized changes in molecular signaling ..
  7. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2011
    ..Since the CSF turns over several times per day, the CSF-choroid-plexus system is ideally suited for triggering rapid and spatially synchronized changes in molecular signaling ..
  8. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2012
    ..molecules and chemokines that are regulated by adenosine signaling to influence lymphocyte migration at the choroid plexus...
  9. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Advanced high resolution in vivo imaging techniques to evaluate changes at the cellular level in the retina, choroid and lamina cribrosa, and these studies will be complemented by ultrastructural studies of the lamina cribrosa of ..
  10. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ..has developed technology to simultaneously deliver multiple regenerative factors derived from cultured choroid plexus (CP) to accelerate wound healing at low therapeutic doses...
  11. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    Kathleen J Sweadner; Fiscal Year: 2010
    ..CSF is produced by the choroid plexuses in the brain's ventricles, and it flows out through other structures...
  12. Combined Computational and Wet Lab Screening for Drugs Tested via OATs
    Sanjay K Nigam; Fiscal Year: 2010
    ..have recently published the Oat1 and Oat3 knockouts, which have defective organic anion transport in kidney and choroid plexus...
  13. Immune Mechanisms in Choroidal Neovascularization
    Rajendra Apte; Fiscal Year: 2009
    ..oxygen balance within the ocular micromilieu and might affect immune effector mechanisms within the retina and choroid. Normal RPE plays a crucial role in maintaining a viable and healthy outer retina...
  14. Role of RPE-derived VEGF in Choroid Development and Stability
    PATRICIA ANN D'AMORE; Fiscal Year: 2013
    ....
  15. Genetic Regulation of Eye Development in Zebrafish
    Jeff Gross; Fiscal Year: 2012
    ..Fusion occurs along a distinct region of the optic cup called the choroid fissure...
  16. Development of the renin-expressing cell
    Maria L Sequeira Lopez; Fiscal Year: 2010
    ..e. skin, choroid plexus, sympathetic ganglia, adrenal medulla and head cartilage)...
  17. Vitamin C and cognition in Alzheimer's disease
    Fiona Edith Harrison; Fiscal Year: 2013
    ..ASC is transported across the choroid plexus and into neurons by the Sodium-dependent Vitamin C Transporter (SVCT2)...
  18. A Role for Melanoregulin in RPE-mediated Phagocytosis
    KATHLEEN B BOESZE BATTAGLIA; Fiscal Year: 2010
    ..contributes to RPE dysfunction leading to long-term pathologic changes in RPE, Bruch's membrane (BM), and choroid. This proposal expands previous RPE intracellular trafficking studies in a new direction and represents a unique ..
  19. RPE Lactate Transporters: A Role in Retinal Survival
    Nancy Philp; Fiscal Year: 2009
    ..transporters that facilitate the transepithelial movement of lactate from the subretinal space to the choroid;MCT1 in the apical membrane and MCT3 in the basolateral membrane...
  20. RPE Lactate Transporters: A Role in Retinal Survival
    NANCY JEAN PHILP; Fiscal Year: 2012
    ..transporters that facilitate the transepithelial movement of lactate from the subretinal space to the choroid;MCT1 in the apical membrane and MCT3 in the basolateral membrane...
  21. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2012
    ..a signaling cascade that originates in the retina, travels through the retinal pigment epithelium (RPE) and choroid, and reaches the sclera (the fibrous outer coat of the eye);and 3) fibroblasts in the sclera which respond to the ..
  22. Dynamic ICG and FA Software
    Timothy Holmes; Fiscal Year: 2009
    ..dyes used clinically in eye fundus imaging, primarily for detecting vascular abnormalities in the retina and choroid, which is the layer behind the retina...
  23. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..channel operates at a wavelength of 1 5m for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD...
  24. Photoreceptor Integrity Software
    Timothy J Holmes; Fiscal Year: 2012
    ..The detection and visualization of other layers in the retina and choroid will be a natural fallout of this work, so the end product will have a wealth of functionalty demanded by the ..
  25. Neural Control of Choroidal Blood Flow
    ANTON J REINER; Fiscal Year: 2013
    ..We have found that the vasodilatory parasympathetic facial nerve input to choroid from the pterygopalatine ganglion appears to maintain high ChBF during low systemic blood pressure...
  26. Topical Nanoparticles for CNV
    Uday B Kompella; Fiscal Year: 2010
    ..Choroidal neovascularization (CNV), the pathologic creation of new blood vessels in the choroid layer of the eye, is a principal cause of blindness due to AMD...
  27. Birth and Death of Choriocapillaris.
    GERARD ANTHONY LUTTY; Fiscal Year: 2013
    ..We hypothesize that dysfunction in CC transport results in the serum protein accumulation in choroid we observe, which is toxic to CC and may be the reason that CC die in AMD...
  28. Effect of NF1 mutation on choroid plexus function
    Sally Temple; Fiscal Year: 2013
    ..cells are bathed in cerebrospinal fluid (CSF) that provides growth/signaling factors produced by the nearby choroid plexus (CP)...
  29. Dorsal midline patterning in the vertebrate CNS
    KATHLEEN JOYCE MILLEN; Fiscal Year: 2013
    ..acts intrinsically in the cortical hem to regulate cortical hem neurogenesis and if the adjacent telencephalic choroid plexus, where Lmx1a is also expressed, also influences hem development...
  30. The Mechanism of the Outer Blood-Retina Barrier Breakdown
    Zsolt Ablonczy; Fiscal Year: 2013
    ..Vascular endothelial growth factor (VEGF) is required for normal vascular development in the choroid, but it is also the principle cytokine responsible for neovascularization in many proliferative eye diseases...
  31. Auto-Antibodies as Serum Biomarkers for Age-Related Macular Degeneration
    Alessandro Iannaccone; Fiscal Year: 2010
    ..Drusen have high contents of inflammatory effectors and by-products, and dendritic cells (DCs) from the choroid (Ch), which are among the resident antigen-presenting cells of the eye, are recruited to and infiltrate the BM ..
  32. Adenosine receptor A2A regulation of EAE and CNS lymphocyte infiltration
    Jeffrey H Mills; Fiscal Year: 2011
    ..Additionally, we found that CD73 and the A2AAR are highly expressed on the choroid plexus, a CNS structure which controls the passage of lymphocytes from the blood to CSF and has been proposed to ..
  33. A 2-photon/confocal microscope for imaging of neural development and function
    Wesley J Thompson; Fiscal Year: 2010
    ..mechanisms specifying the fates of individual neurons in the developing midbrain, an NEI-funded study of choroid fissure closure and its genetic regulation in the zebrafish eye, and an NINDS-funded study of mechanisms by which ..
  34. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2013
    ..We will also develop long wavelength OCT which enables imaging of the choroid and internal structure of the optic nerve head. Aim 2...
  35. REGULATION OF SCLERAL GROWTH AND REMODELING IN MYOPIA
    Jody A Summers; Fiscal Year: 2013
    ..nothing is known about the cellular and molecular events responsible for the regulation of atRA activity in the choroid and sclera...
  36. Molecular Physiology of Bicarbonate Transport in the Brain
    Walter F Boron; Fiscal Year: 2012
    ..nNCBTs also contribute to HCO3 secretion by choroid plexus and blood-brain barrier endothelial cells...
  37. Substrate Specificity of the Choroid Plexus and Kidney Transporter Oat1
    Sanjay K Nigam; Fiscal Year: 2013
    ..Also discussed are "alternative" computational and wet lab approaches in case the primary approach is less successful than anticipated. ..
  38. Genetic Basis of Congenital Anophthalmia
    THOMAS M GLASER; Fiscal Year: 2013
    ..microphthalmia and coloboma (MAC) are birth defects in which the eyes are absent or very small, or where the choroid fissure fails to close during optic cup development...
  39. In Vivo Evaluation of Presbyopia
    Kathryn Richdale; Fiscal Year: 2013
    ..eyes;and ex vivo work using non- physiological forces and discounting the role of the iris, vitreous, and choroid. Presbyopia may likely be a multifactorial process, as no one mechanism is able to explain the early onset, ..
  40. Ocular diurnal rhythms and eye growth
    Debora L Nickla; Fiscal Year: 2012
    ..NO is produced by the choroid, and inhibiting its synthesis pharmacologically prevents both the choroidal and growth responses to defocus...
  41. Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration
    Qifa Zhou; Fiscal Year: 2013
    ..In this project we propose to develop and test means for imaging the elastic properties of the retina/choroid by detection of minute displacements generated within these structures induced by acoustic radiation force...
  42. Holography-based Photoacoustic Imaging of the Retina
    PARAG VIJAY CHITNIS; Fiscal Year: 2013
    ..a photorefractive crystal (PRC) and potentially can provide anatomical and functional images of the retina, choroid, and the optic nerve with ultra-fine-resolution...
  43. Recapitulating developmental pathways to improve iPSC-RPE derivation protocols
    PETER DWAYNE WESTENSKOW; Fiscal Year: 2013
    ..RPE functions include the vectorial transport of ions and water between the choroid circulation and retina, light absorption, and phagocytosis of light damaged photoreceptor outer segments...
  44. Choroid Plexus as a Target in Metal-Induced Neurotoxicity
    Wei Zheng; Fiscal Year: 2013
    ..This research project is designed to test the hypothesis that the choroid plexus, a brain tissue forming a barrier between the blood and cerebrospinal fluid (CSF), regulates Cu transport ..
  45. IGF-II and Insulin Receptors in Neural Stem Cells
    Teresa L Wood; Fiscal Year: 2013
    ..However, IGF-II is expressed at high levels within the choroid plexus, which produces the cerebrospinal fluid that is readily accessible to the NSCs because they extend a ..
  46. Systematic Vertebrate Functional Genomics
    STEPHEN CARL EKKER; Fiscal Year: 2010
    ..Aim III. Isolation of secreted proteins required for cardiovascular formation including the choroid plexus and the behavioral genetics of the stress response. Aim IV...
  47. Neurocognitive outcomes and changes in brain and CSF volume after treatment of po
    BENJAMIN CURTIS WARF; Fiscal Year: 2012
    ..with an inexpensive shunt;d) developed the novel technique of combined endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for treating infant hydrocephalus that avoids the danger of shunt-dependence;e) ..
  48. Confocal Microscope for Live Embryo Imaging in a Shared Resource Facility
    Lawrence S Prince; Fiscal Year: 2010
    ..confocal microscope to study embryonal and fetal development of multiple tissues and organs, including, foregut, choroid plexus, pancreas, lung, kidney, and heart...
  49. Retinal morphogenesis in zebrafish
    Yevgenya Grinblat; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malformations during choroid fissure (CF) closure, an important step in retinal morphogenesis, are a significant cause of congenital visual impairment...
  50. Suprachroidal Drug Delivery for Retina Disorders
    Mark R Prausnitz; Fiscal Year: 2013
    ..the eye, it does not target drug delivery within the eye to the sites of therapeutic action, specifically in the choroid and retina...
  51. OCT Imaging of Diabetic Retinopathy in 1060nm Spectral Range (- for Diagnostic Sc
    Kevin Hsu; Fiscal Year: 2010
    ..The choroid plays an important role in many ocular diseases including DR...
  52. Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and C
    James McAllister; Fiscal Year: 2009
    ..to existing dogmas with new evidence about CSF physiology, including lymphatic, arachnoid, and vascular pathways, choroid plexus physiology, clearance mechanisms, and biomarkers...
  53. 2010 Barriers of the CNS Gordon Research Conference
    Gert Fricker; Fiscal Year: 2010
    ..the basic mechanisms underlying the function of the blood brain barrier (BBB) / neurovascular unit (NVU) and the Choroid Plexus in health and disease...
  54. Transcleral Therapeutics in Diabetic Retinopathy
    Uday B Kompella; Fiscal Year: 2013
    ..This is due to non- productive binding of celecoxib in the pigmented choroid layer...
  55. Noninvasive assessment of tumor malignancy
    Elizabeth Bullitt; Fiscal Year: 2010
    ..The second model is a heavily vascular choroid plexus carcinoma that mimics the growth of metastatic tumors by producing microscopic foci of malignancy that ..
  56. Proteomic Biomarkers for AMD
    John W Crabb; Fiscal Year: 2013
    ..In aim 1, we will test the hypothesis that proteins altered in macular AMD Bruch's membrane choroid complex provide plasma biomarkers of AMD risk...
  57. Regulation of ocular angiogenesis by microRNAs
    Shusheng Wang; Fiscal Year: 2013
    ..We also have preliminary data that miR-126 is expressed specifically in the endothelium in the retina/choroid, and is required for sprouting retinal angiogenesis...
  58. Targeting the choroid plexus for drug translocation into CSF
    Andrew Baird; Fiscal Year: 2010
    ..The goal of this exploratory R21 feasibility research proposal is to identify peptides capable of targeting the choroid plexus (CP) so that they can be evaluated for their capacity to deliver drugs to the CP or across the CP into ..
  59. Mechanisms underlying emmetropization and local eye growth regulation
    CHRISTINE FRANCES WILDSOET; Fiscal Year: 2012
    ..signaling across the retinal pigment epithelium (RPE), which separates the image-processing retina from the choroid and eye shape-determining sclera, using molecular techniques to delineate patterns of gene expression in eyes ..
  60. 2012 Barriers of the CNS Gordon Research Conference &Gordon Research Seminar
    Quentin R Smith; Fiscal Year: 2012
    ..e., brain vasculature, choroid plexus epithelium, arachnoid membrane) in health and disease and to explore strategies for overcoming these ..
  61. Molecular insights into the pathogenesis of Sorsby Fundus Dystrophy
    Jian Hua Qi; Fiscal Year: 2013
    ..of increased mutant TIMP3 protein glycosylation with a concomitant increase in mutant TIMP3 levels in RPE- choroid tissue of S156C-TIMP3 knock-in mice...
  62. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009
    ..on HPA axis activation occurs due to alterations in PRL transport into the brain via specific receptors in the choroid plexus. The duration of the PRL increase is important...
  63. DOMINANT WHITE (I) GENE OF CHICKENS: MODEL FOR VITILIGO
    ROGER BOWERS; Fiscal Year: 1991
    ..hypothesis that the dominant white gene white gene (I) expresses itself in WL chickens by making the feather and choroid melanocytes more sensitive to a cytotoxic agent, possibly a compound produced by the melanocyte itself...
  64. Role of OFQ/N in Regulating the Prolactin Response to Stress
    Phyllis Callahan; Fiscal Year: 2007
    ..knock out post-partum females are not hyperprolactinemic and do not seem to have increased PRL-R mRNA in the choroid plexus of the brain, making them much different from normal post-partum females...
  65. Development of therapeutic monoclonal antibody to the bioactive lipid lysophospha
    Rosalia Matteo; Fiscal Year: 2009
    ..placed SKOV3 tumor cells, reduced neovascularization in two classical angiogenic models (Matrigel plug and choroid neovascularization models) and showed preliminary anti-metastatic activity when tested in the B16-F10 melanoma ..
  66. BIOSYNTHETIC ACTIVITY OF THE CHOROID PLEXUS
    Joseph Herbert; Fiscal Year: 1993
    The choroid plexus (CP) forms a major interface of the blood- cerebrospinal fluid (CSF) barrier and is responsible for the secretion of a large fraction of the CSF...
  67. REGULATING CEREBROSPINAL FLUID FORMATION
    Barry Hoffer; Fiscal Year: 1992
    ..to develop further our understanding of the neural control of the production of cerebrospinal fluid (CSF) by the choroid plexus. It is currently known that sympathetic tone inhibits secretion of CSF...
  68. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2002
    ..e., the choroid plexus epithelium...
  69. PERINATAL METABOLIC STRESS AND BRAIN GLUCOSE TRANSPORT
    SUSAN VANNUCCI; Fiscal Year: 1999
    ..GLUT1 is most concentrated in the blood-brain barrier and choroid plexus; GLUT3 is probably the major neuronal glucose transporter...
  70. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    b>Choroid plexus (CP) has a great impact on the neuronal extracellular fluid environment...
  71. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2007
    ..2) Complement C5 and IgG are deposited in the retinal pigmented epithelium (RPE) and choroid of both knockout strains as they age, as in patients with AMD...
  72. BLOOD-BRAIN BARRIER IN NORMAL & EXPERIMENTAL BRAIN
    RICHARD BROADWELL; Fiscal Year: 1990
    ..of circulating proteins, peptides, and positively charge molecules through the cerebral endothelium and choroid epithelium...