optic disk

Summary

Summary: The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve.

Top Publications

  1. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
  2. ncbi Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
    Ileana Soto
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:548-61. 2008
  3. pmc A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma
    Claude F Burgoyne
    Optic Nerve Head Research Laboratory, Part of the Discoveries in Sight Research Laboratories of the Devers Eye Institute, Legacy Health System, 1225 NE 2nd Ave, Portland, OR 97232, USA
    Exp Eye Res 93:120-32. 2011
  4. pmc Retinal thickness decreases with age: an OCT study
    B Alamouti
    University of Freiburg Eye Hospital, Germany
    Br J Ophthalmol 87:899-901. 2003
  5. ncbi The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage
    Claude F Burgoyne
    LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
    Prog Retin Eye Res 24:39-73. 2005
  6. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
  7. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
  8. pmc Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography
    O Rese J Knight
    Bascom Palmer Eye Institute, Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami 33136, Florida, USA
    Ophthalmology 116:1271-7. 2009
  9. ncbi Astrocytes in glaucomatous optic neuropathy
    M Rosario Hernandez
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Prog Brain Res 173:353-73. 2008
  10. pmc Optic disc size in a population based study in northern China: the Beijing Eye Study
    Y Wang
    Department of Opthalmology and Eye Hospital, Tongren Hospital, Beijing, China
    Br J Ophthalmol 90:353-6. 2006

Research Grants

  1. EARLY DETECTION OF GLAUCOMA DAMAGE
    Henry Jampel; Fiscal Year: 2004
  2. OCULAR FUNCTIONS & PEPTIDE HORMONE SYSTEMS
    James Ryan; Fiscal Year: 1991
  3. UVEAL VASCULATURE: OPTIC NERVE MICROCIRCULATION
    George Cioffi; Fiscal Year: 2003
  4. Development of Retinal Receptive Fields
    NORBERTO GRZYWACZ; Fiscal Year: 2006
  5. Molecular Mechanisms of Visual Thalamic Development
    Sam H Horng; Fiscal Year: 2010
  6. Diagnostic Innovations in Glaucoma: Clinical Electrophysiology
    Christopher Bowd; Fiscal Year: 2008
  7. Quan11tification of Glaucomatous Optic Neuropathy
    Christopher Girkin; Fiscal Year: 2006
  8. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
  9. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    Harry Quigley; Fiscal Year: 2008
  10. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2008

Detail Information

Publications284 found, 100 shown here

  1. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ..There is no consensus on the efficacy of medical treatment in delaying or preventing the onset of POAG in individuals with elevated IOP. Therefore, we designed a randomized clinical trial, the Ocular Hypertension Treatment Study...
  2. ncbi Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
    Ileana Soto
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:548-61. 2008
    ....
  3. pmc A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma
    Claude F Burgoyne
    Optic Nerve Head Research Laboratory, Part of the Discoveries in Sight Research Laboratories of the Devers Eye Institute, Legacy Health System, 1225 NE 2nd Ave, Portland, OR 97232, USA
    Exp Eye Res 93:120-32. 2011
    ..The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 19, 297-321.; Hernandez, M.R., Pena, J.D., 1997. The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol. 115, 389-395.)...
  4. pmc Retinal thickness decreases with age: an OCT study
    B Alamouti
    University of Freiburg Eye Hospital, Germany
    Br J Ophthalmol 87:899-901. 2003
    ..The aim of the study was to check this hypothesis using optical coherence tomography, and additionally to determine the reproducibility of OCT measurements in this area...
  5. ncbi The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage
    Claude F Burgoyne
    LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
    Prog Retin Eye Res 24:39-73. 2005
    ....
  6. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
    ....
  7. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
    ....
  8. pmc Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography
    O Rese J Knight
    Bascom Palmer Eye Institute, Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami 33136, Florida, USA
    Ophthalmology 116:1271-7. 2009
    ....
  9. ncbi Astrocytes in glaucomatous optic neuropathy
    M Rosario Hernandez
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Prog Brain Res 173:353-73. 2008
    ..Our data also suggests that the creation of a non-supportive environment for the survival of RGC axons through remodeling of the ONH by reactive astrocytes leads to progression of glaucomatous optic neuropathy...
  10. pmc Optic disc size in a population based study in northern China: the Beijing Eye Study
    Y Wang
    Department of Opthalmology and Eye Hospital, Tongren Hospital, Beijing, China
    Br J Ophthalmol 90:353-6. 2006
    ..To determine the optic disc size in the adult Chinese population in an urban and a rural region of Beijing...
  11. ncbi Ophthalmoscopic evaluation of the optic nerve head
    J B Jonas
    Department of Ophthalmology and Eye Hospital, University Erlangen Nurnberg, Erlangen, Germany
    Surv Ophthalmol 43:293-320. 1999
    ..These changes can be described by the following variables: size and shape of the optic disk; size, shape, and pallor of the neuroretinal rim; size of the optic cup in relation to the area of the disk; ..
  12. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    ..A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated. The nerve fiber layer (NFL) thickness, macula thickness map, and optic nerve head (ONH) parameters in normal eyes were studied...
  13. ncbi Risk factors for visual field progression in treated glaucoma
    Carlos Gustavo V De Moraes
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 E 14th St, New York, NY 10003, USA
    Arch Ophthalmol 129:562-8. 2011
    ..To determine intraocular pressure (IOP)-dependent and IOP-independent variables associated with visual field (VF) progression in treated glaucoma...
  14. ncbi Ocular blood flow assessment using continuous laser Doppler flowmetry
    Charles E Riva
    Department of Ophthalmology Dir Prof Emilio Campos, University of Bologna, Italy
    Acta Ophthalmol 88:622-9. 2010
    ..Various problems still need to be solved in order to bring to light the full potential of LDF in the assessment of microcirculatory haemodynamics...
  15. ncbi Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography
    Eun Ji Lee
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Am J Ophthalmol 152:87-95.e1. 2011
    ..To investigate whether the enhanced depth imaging technique (EDI) may improve the visualization of the lamina cribrosa using spectral-domain optical coherence tomography (SD-OCT)...
  16. ncbi Structural basis of glaucoma: the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure
    Chao Dai
    Spinal Repair Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London WC1N 3BG, UK
    Glia 60:13-28. 2012
    ....
  17. ncbi Risk factors for progression of visual field abnormalities in normal-tension glaucoma
    S Drance
    Bascom Palmer Eye Institue, Miami, FL 33101-6880, USA
    Am J Ophthalmol 131:699-708. 2001
    ....
  18. ncbi Optic disc pit: a review
    Ilias Georgalas
    Department of Ophthalmology, G Gennimatas Hospital of Athens, University of Athens, 59 Chrysanthemon str, 15452 Athens, Greece
    Graefes Arch Clin Exp Ophthalmol 249:1113-22. 2011
    ..The main complication of this condition, termed optic disc pit maculopathy, is associated with visual deterioration. Treatment of optic disc pit maculopathy remains challenging...
  19. ncbi In vivo evaluation of focal lamina cribrosa defects in glaucoma
    Saman Kiumehr
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA
    Arch Ophthalmol 130:552-9. 2012
    ..To assess focal lamina cribrosa (LC) defects in glaucoma using enhanced depth imaging optical coherence tomography and to investigate their spatial relationships with neuroretinal rim and visual field loss...
  20. ncbi Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head
    Michaël J A Girard
    Department of Bioengineering, Imperial College, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:7738-48. 2011
    ..To improve the quality of optical coherence tomography (OCT) images of the optic nerve head (ONH)...
  21. ncbi Progression detection capability of macular thickness in advanced glaucomatous eyes
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 119:308-13. 2012
    ..To evaluate the progression rate of macular and circumpapillary retinal nerve fiber layer (RNFL) thickness in advanced glaucomatous eyes using spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA)...
  22. ncbi Comparison of choroidal and optic nerve head blood flow regulation during changes in ocular perfusion pressure
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 53:4337-46. 2012
    ....
  23. ncbi Altered nitric oxide system in patients with open-angle glaucoma
    Kaija Polak
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Arch Ophthalmol 125:494-8. 2007
    ..To investigate the ocular blood flow response to systemic nitric oxide synthase inhibition in patients with primary open-angle glaucoma...
  24. ncbi Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
    ..This instability, in turn, induces a repeated mild reperfusion injury. The resulting oxidative stress contributes to the pathogenesis of glaucomatous optic neuropathy...
  25. pmc Ability of cirrus HD-OCT optic nerve head parameters to discriminate normal from glaucomatous eyes
    Jean Claude Mwanza
    Bascom Palmer Eye Institute, Miami Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Ophthalmology 118:241-8.e1. 2011
    ..Dublin, CA) to discriminate between normal and glaucomatous eyes and to compare them with the discriminating ability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements performed with Cirrus HD-OCT...
  26. pmc Optic nerve head and retinal nerve fiber layer analysis: a report by the American Academy of Ophthalmology
    Shan C Lin
    Ophthalmology 114:1937-49. 2007
    ..To evaluate the current published literature on the use of optic nerve head (ONH) and retinal nerve fiber layer (RNFL) measurement devices in diagnosing open-angle glaucoma and detecting progression...
  27. pmc Analysis of normal peripapillary choroidal thickness via spectral domain optical coherence tomography
    Joseph Ho
    New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA
    Ophthalmology 118:2001-7. 2011
    ..To analyze the normal peripapillary choroidal thickness utilizing a commercial spectral domain optical coherence tomography (OCT) device and determine the intergrader reproducibility of this method...
  28. ncbi Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography
    Joshua R Ehrlich
    Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USA
    Exp Eye Res 92:189-94. 2011
    ..We conclude that eyes with POAG did not demonstrate reduced CT nor was there a correlation between RNFL and CT maps. This study does not support the use of CT assessment in glaucoma diagnosis or management...
  29. ncbi Macular schisis in a patient without an optic disk pit optical coherence tomographic findings
    Richard F Spaide
    LuEsther T Mertz Retinal Research Center, ManhattanEye, Ear and Throat Hospital, New York, USA
    Retina 23:238-40. 2003
  30. ncbi Histology of the parapapillary region in high myopia
    Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University Heidelberg, Germany
    Am J Ophthalmol 152:1021-9. 2011
    ..To examine histomorphometrically the parapapillary region in highly myopic eyes...
  31. ncbi Blood pressure, perfusion pressure, and glaucoma
    Joseph Caprioli
    Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Am J Ophthalmol 149:704-12. 2010
    ..To provide a critical review of the relationships between blood pressure, ocular blood flow, and glaucoma and the potential for glaucoma treatment through modulation of ocular perfusion...
  32. ncbi Axonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure
    Chandrakumar Balaratnasingam
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia
    Invest Ophthalmol Vis Sci 48:3632-44. 2007
    ....
  33. pmc Effects of age on optical coherence tomography measurements of healthy retinal nerve fiber layer, macula, and optic nerve head
    Kyung Rim Sung
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Ophthalmology 116:1119-24. 2009
    ..To determine the effects of age on global and sectoral peripapillary retinal nerve fiber layer (RNFL), macular thicknesses, and optic nerve head (ONH) parameters in healthy subjects using optical coherence tomography (OCT)...
  34. ncbi What is the link between vascular dysregulation and glaucoma?
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
    Surv Ophthalmol 52:S144-54. 2007
    ..This, in turn, leads to unstable oxygen supply, which seems to be a relevant component in the pathogenesis of glaucomatous optic neuropathy...
  35. pmc Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements
    Alberto O Gonzalez-Garcia
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, California, USA
    Am J Ophthalmol 147:1067-74, 1074.e1. 2009
    ..To evaluate RTVue spectral-domain optical coherence tomography (OCT) (Optovue Inc, Fremont, California, USA) reproducibility and to assess agreement with Stratus time-domain OCT (Carl Zeiss Meditec, Dublin, California, USA) measurements...
  36. ncbi Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 116:1264-70, 1270.e1. 2009
    ..To study the relationship between retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT)...
  37. ncbi Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria
    Neville N Osborne
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Prog Brain Res 173:339-52. 2008
    ....
  38. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  39. ncbi Ranking of optic disc variables for detection of glaucomatous optic nerve damage
    J B Jonas
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 41:1764-73. 2000
    ....
  40. ncbi High myopia and glaucoma susceptibility the Beijing Eye Study
    Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Ophthalmology 114:216-20. 2007
    ..To evaluate whether marked myopia, compared with moderate myopia and low myopia, is associated with a higher prevalence of glaucomatous optic nerve damage...
  41. ncbi Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma
    Keith R G Martin
    Glaucoma Research Laboratory, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA
    Exp Eye Res 83:255-62. 2006
    ..The effect of IOP elevation on other motor proteins deserves further investigation in the future...
  42. ncbi Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Ophthalmology 116:1257-63, 1263.e1-2. 2009
    ..Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.)...
  43. ncbi Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage
    Ramanjit Sihota
    Glaucoma Research Facility, Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Invest Ophthalmol Vis Sci 47:2006-10. 2006
    ..To evaluate the role and ability of optical coherence tomography (OCT) to detect differences in peripapillary retinal nerve fiber layer (RNFL) thickness between normal and glaucomatous eyes and also between different severities of glaucoma...
  44. ncbi Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography
    B C Chauhan
    Department of Ophthalmology, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 41:775-82. 2000
    ..To describe and evaluate a new statistical technique for detecting topographic changes in the optic disc and peripapillary retina measured with confocal scanning laser tomography...
  45. ncbi Glaucoma: macrocosm to microcosm the Friedenwald lecture
    Harry A Quigley
    Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2662-70. 2005
  46. ncbi Horizontal central ridge of the lamina cribrosa and regional differences in laminar insertion in healthy subjects
    Sung Chul Park
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York, USA
    Invest Ophthalmol Vis Sci 53:1610-6. 2012
    ..To assess the general morphology and position of the lamina cribrosa (LC) in healthy subjects using enhanced depth imaging-optical coherence tomography (EDI-OCT)...
  47. pmc Reproducibility of measuring lamina cribrosa pore geometry in human and nonhuman primates with in vivo adaptive optics imaging
    Kevin M Ivers
    College of Optometry, University of Houston, Houston, Texas 77204, USA
    Invest Ophthalmol Vis Sci 52:5473-80. 2011
    ..Repeatability was assessed in imaging laminar pores in normal living eyes with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO)...
  48. ncbi Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea/hypopnea syndrome
    Pei Wen Lin
    Department of Ophthalmology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Graefes Arch Clin Exp Ophthalmol 249:585-93. 2011
    ....
  49. pmc Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma
    Renato Lisboa
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA
    Invest Ophthalmol Vis Sci 54:3417-25. 2013
    ..To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage...
  50. ncbi Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls
    Younes Agoumi
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Canada
    Ophthalmology 118:52-9. 2011
    ..To determine the response of the anterior lamina cribrosa and prelaminar tissue to acute elevation of intraocular pressure (IOP) in glaucoma patients and healthy subjects...
  51. ncbi Evaluation of lamina cribrosa in pseudoexfoliation syndrome using spectral-domain optical coherence tomography enhanced depth imaging
    Soa Kim
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 120:1798-803. 2013
    ..The results were compared with those of patients with primary open-angle glaucoma (POAG)...
  52. ncbi Ischemic optic neuropathy
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1091, USA
    Prog Retin Eye Res 28:34-62. 2009
    ..This review discusses the current concepts on various issues related to various types of ischemic optic neuropathy...
  53. ncbi Autoregulation of human optic nerve head blood flow in response to acute changes in ocular perfusion pressure
    C E Riva
    Institut de Recherche en Ophthalmologie, Sion, Switzerland
    Graefes Arch Clin Exp Ophthalmol 235:618-26. 1997
    ..Therefore, we investigated the relationship between F(onh) and mean ocular perfusion pressure (PPm) in normal volunteers when PPm is decreased through elevation of the intraocular pressure (IOP)...
  54. ncbi Morning glory syndrome: clinical, computerized tomographic, and ultrasonographic findings
    Paul Harasymowycz
    Hopital Maisonneuve Rosemont, Centre de Recherche Guy Bernier, Montreal, Quebec, Canada
    J Pediatr Ophthalmol Strabismus 42:290-5. 2005
    ..To evaluate the ophthalmic, radiologic, and ultrasonographic findings in morning glory syndrome...
  55. pmc Longitudinal detection of optic nerve head changes by spectral domain optical coherence tomography in early experimental glaucoma
    Lin He
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health, Portland, Oregon
    Invest Ophthalmol Vis Sci 55:574-86. 2014
    ....
  56. ncbi Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study
    Linda M Zangwill
    Hamilton Glaucoma Center and Diagnostic Imaging Laboratory, Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA
    Arch Ophthalmol 123:1188-97. 2005
    ..To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension...
  57. ncbi Factors associated with focal lamina cribrosa defects in glaucoma
    Sung Chul Park
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, New York
    Invest Ophthalmol Vis Sci 54:8401-7. 2013
    ..To assess factors associated with focal lamina cribrosa (LC) defects in glaucoma...
  58. ncbi Nitric oxide synthase in the human glaucomatous optic nerve head
    A H Neufeld
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Arch Ophthalmol 115:497-503. 1997
    ....
  59. ncbi Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy
    Ines Contreras
    Ramon y Cajal Hospital, Madrid, Spain
    Invest Ophthalmol Vis Sci 48:4087-92. 2007
    ..To describe the characteristics of the optic nerve head (ONH) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and compare them with control subjects by using optical coherence tomography (OCT)...
  60. ncbi Optic disk ovality as an index of tilt and its relationship to myopia and perimetry
    Eugene Tay
    Moorfields Eye Hospital, Institute of Ophthalmology, London, England
    Am J Ophthalmol 139:247-52. 2005
    To examine the association of optic disk ovality with myopic refractive error, axial length, and the visual field.
  61. ncbi Cataract and glaucoma case detection for Vision 2020 programs in Africa: an evaluation of 6 possible screening tests
    Colin Cook
    Department of Ophthalmology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    J Glaucoma 18:557-62. 2009
    ..To determine if there is a screening test or a combination of screening tests that may be suitable for cataract and glaucoma case detection in Vision 2020 programs in Africa...
  62. ncbi Reactivation of optic nerve head astrocytes by TGF-beta2 and H2O2 is accompanied by increased Hsp32 and Hsp47 expression
    Alice L Yu
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Invest Ophthalmol Vis Sci 50:1707-17. 2009
    ..The goal of the present study was to determine whether new potentially involved Hsps, such as Hsp32, -47, -60, and -70, are expressed in the reactivation process of ONH astrocytes mediated by TGF-beta2 and H(2)O(2)...
  63. ncbi Enhancement of lamina cribrosa visibility in optical coherence tomography images using adaptive compensation
    Jean Martial Mari
    INSERM 1032, Universite de Lyon, Lyon, France
    Invest Ophthalmol Vis Sci 54:2238-47. 2013
    ..We improved the visibility of the lamina cribrosa (LC), including its posterior boundary, in optical coherence tomography (OCT) images of the human optic nerve head (ONH)...
  64. pmc Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography
    Alexandre S C Reis
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
    Ophthalmology 119:738-47. 2012
    ..To characterize optic nerve head (ONH) anatomy related to the clinical optic disc margin with spectral domain-optical coherence tomography (SD-OCT)...
  65. pmc Understanding disparities among diagnostic technologies in glaucoma
    Carlos Gustavo V De Moraes
    Einhorn Clinical Research Center, The New York Eye and Ear Infirmary, and Department of Ophthalmology, New York University School of Medicine, New York, New York 10003, USA
    Arch Ophthalmol 130:833-40. 2012
    ..To investigate causes of disagreement among 3 glaucoma diagnostic techniques: standard automated achromatic perimetry (SAP), the multifocal visual evoked potential technique (mfVEP), and optical coherence tomography (OCT)...
  66. ncbi Cavitary anomalies of the optic disc: neurologic significance
    Karl C Golnik
    Department of Ophthalmology, University of Cincinnati and The Cincinnati Eye Institute, 1945 CEI Drive, Cincinnati, OH 45242, USA
    Curr Neurol Neurosci Rep 8:409-13. 2008
    ..This is further complicated by historical inconsistencies in the literature. Advances in molecular genetics may help to define clearly the etiology of these anomalies...
  67. pmc A comparison of stereoscopic and monoscopic evaluation of optic disc topography using a digital optic disc stereo camera
    B Parkin
    Southampton Eye Unit, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Ophthalmol 85:1347-51. 2001
    ..To compare stereophotographic and monophotographic optic disc assessments made using a digital optic disc stereo camera...
  68. pmc 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes
    P E Malone
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 303 E Chicago, Tarry 13 711, Chicago, IL 60611, USA
    Exp Eye Res 84:444-54. 2007
    ....
  69. ncbi Intracranial vascular anomalies in patients with morning glory disk anomaly
    Phoebe D Lenhart
    Department of Pediatric Ophthalmology, Emory Eye Center, Atlanta, GA 30322, USA
    Am J Ophthalmol 142:644-50. 2006
    ..We evaluated a series of patients with MGDA to ascertain the frequency of cerebrovascular anomalies...
  70. ncbi Glaucoma diagnostic capabilities of optic nerve head parameters as determined by Cirrus HD optical coherence tomography
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    J Glaucoma 21:498-504. 2012
    ..0.0.326)...
  71. ncbi Evidence that nitric oxide is involved in autoregulation in optic nerve head of rabbits
    Takashi Okuno
    Department of Ophthalmology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki, Osaka, 569 8686 Japan
    Invest Ophthalmol Vis Sci 43:784-9. 2002
    ..To determine the role played by nitric oxide (NO) in the autoregulation of circulation in the optic nerve head (ONH)...
  72. ncbi Evaluation of congenital optic disc pits and optic disc colobomas by swept-source optical coherence tomography
    Kyoko Ohno-Matsui
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 54:7769-78. 2013
    ..To investigate the structural abnormalities of optic disc pits and colobomas by swept-source optical coherence tomography (OCT)...
  73. ncbi Involvement of glial cells in the autoregulation of optic nerve head blood flow in rabbits
    Maho Shibata
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 53:3726-32. 2012
    ..To investigate the involvement of glial cells in the autoregulation of optic nerve head (ONH) blood flow in response to elevated intraocular pressure (IOP)...
  74. pmc IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models
    Ian A Sigal
    Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 52:1896-907. 2011
    ..To study the anterior-posterior lamina cribrosa deformation (LCD) and the scleral canal expansion (SCE) produced by an increase in IOP and identify the main factors and interactions that determine these responses in the monkey...
  75. ncbi A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images
    Heping Xu
    Department of Ophthalmology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK
    Exp Eye Res 87:319-26. 2008
    ....
  76. pmc Optic disc morphology in open-angle glaucoma compared with anterior ischemic optic neuropathies
    Helen V Danesh-Meyer
    New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
    Invest Ophthalmol Vis Sci 51:2003-10. 2010
    ..NFL thickness was greater at the same MD for both AAION and NAION compared with OAG. Conclusions. NAION and AAION cause loss of RGCs, but have significantly different disc topography compared with OAG at a given level of RGC loss...
  77. ncbi Posterior ciliary artery circulation in health and disease: the Weisenfeld lecture
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Invest Ophthalmol Vis Sci 45:749-57; 748. 2004
  78. ncbi Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki eye study
    Fotis Topouzis
    II Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Am J Ophthalmol 142:60-67. 2006
    To study the association of blood pressure (BP) status on the optic disk structure as measured with the Heidelberg Retina Tomograph (HRT) in people without glaucoma.
  79. ncbi Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal
    Jesper Leth Hougaard
    Department of Clinical Sciences, Ophthalmology, Malmo University Hospital, Lund University, Malmo, Sweden
    Acta Ophthalmol 86:569-75. 2008
    ..We aimed to compare the retinal nerve fibre layer (RNFL) in different Stratus optical coherence tomography (OCT) images in glaucoma eyes with RNFL thickness values within normal limits...
  80. ncbi Comparison of retinal nerve fiber layer thickness and optic disk algorithms with optical coherence tomography to detect glaucoma
    Anita Manassakorn
    Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Am J Ophthalmol 141:105-115. 2006
    To compare the performance of the retinal nerve fiber layer (RNFL) thickness and optic disk algorithms as determined by optical coherence tomography to detect glaucoma.
  81. ncbi Posner-Schlossman syndrome and nonarteritic anterior ischemic optic neuropathy
    Inci Irak
    Department of Ophthalmology and Visual Sciences and the John A Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Neuroophthalmol 23:264-7. 2003
    ....
  82. ncbi Nonarteritic anterior ischemic optic neuropathy associated with acute glaucoma secondary to Posner-Schlossman syndrome
    Rubin Kim
    Kresge Eye Institute, 4717 St Antoine, Detroit, MI 48201, USA
    Arch Ophthalmol 121:127-8. 2003
  83. ncbi Longitudinal changes in retinal nerve fiber layer thickness after acute primary angle closure measured with optical coherence tomography
    Jen Chia Tsai
    Department of Ophthalmology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung County 833, Taiwan
    Invest Ophthalmol Vis Sci 48:1659-64. 2007
    ..Longitudinal follow-up of peripapillary retinal nerve fiber layer (RNFL) thickness after an episode of acute primary angle closure (APAC) using Stratus optical coherence tomography (OCT)...
  84. ncbi Optic disc and peripapillary morphology in unilateral nonarteritic anterior ischemic optic neuropathy and age- and refraction-matched normals
    Hitomi Saito
    Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Ophthalmology 115:1585-90. 2008
    ....
  85. ncbi Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?
    Christian Albrecht May
    Department of Anatomy, Carl Gustav Carus Medical Faculty, TU Dresden, Dresden, Germany
    Acta Neuropathol 111:158-67. 2006
    ..In addition, astrocytes in the ON head form extracellular material similar to that found in human glaucomatous eyes...
  86. ncbi The effect of scan diameter on retinal nerve fiber layer thickness measurement using stratus optic coherence tomography
    Giacomo Savini
    Centro Salus, Bologna, Italy
    Arch Ophthalmol 125:901-5. 2007
    ..To study how customizing the peripapillary scan diameter on the basis of optic nerve head (ONH) diameter affects retinal nerve fiber layer (RNFL) thickness measurements using Stratus optical coherence tomography (OCT)...
  87. ncbi In-vivo microstructural anatomy of beta-zone parapapillary atrophy in glaucoma
    Sung Chul Park
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA
    Invest Ophthalmol Vis Sci 51:6408-13. 2010
    ..To assess the microstructural anatomy of clinical β-zone parapapillary atrophy (βPPA) by using Fourier-domain optical coherence tomography (FD-OCT)...
  88. ncbi Optic disc morphology after arteritic anterior ischemic optic neuropathy
    S S Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 108:1586-94. 2001
    ..e., ischemia of the optic nerve head). The subject is discussed at length...
  89. ncbi Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography
    Felipe A Medeiros
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093 0946, USA
    Am J Ophthalmol 139:44-55. 2005
    ..To compare the ability of optical coherence tomography retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to differentiate between healthy eyes and eyes with glaucomatous visual field loss...
  90. ncbi Bayesian machine learning classifiers for combining structural and functional measurements to classify healthy and glaucomatous eyes
    Christopher Bowd
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:945-53. 2008
    ....
  91. pmc Comparison of optic nerve head assessment with a digital stereoscopic camera (discam), scanning laser ophthalmoscopy, and stereophotography
    Anthony J Correnti
    New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 110:1499-505. 2003
    ..Hereford, UK), confocal scanning laser ophthalmoscopy (CSLO), and stereoscopic disc photography with respect to optic nerve head (ONH) measurements and glaucoma status...
  92. ncbi Mapping standard automated perimetry to the peripapillary retinal nerve fiber layer in glaucoma
    Antonio Ferreras
    Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain
    Invest Ophthalmol Vis Sci 49:3018-25. 2008
    ..To establish a map relating visual field (VF) test points to corresponding areas of the retinal nerve fiber layer (RNFL) measured with optical coherence tomography (OCT) in patients with glaucomatous optic neuropathy...
  93. ncbi Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells
    Gulab S Zode
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Invest Ophthalmol Vis Sci 48:5058-67. 2007
    ..The purpose of the present study was to determine whether human ONH tissues express the canonical BMP signaling pathway and whether ONH cells secrete BMP-4 and respond to exogenous BMP-4 through this pathway...
  94. ncbi Increase in dephosphorylation of the heavy neurofilament subunit in the monkey chronic glaucoma model
    Kenji Kashiwagi
    Department of Ophthalmology, Yamanashi Medical University, 1110 Shimokato, Tamaho, Yamanashi 409 3898, Japan
    Invest Ophthalmol Vis Sci 44:154-9. 2003
    ....
  95. ncbi Optic nerve head sector analysis recognizes glaucoma most effectively around disc poles
    K G Gundersen
    Department of Ophthalmology, Malmo University Hospital, Sweden
    Acta Ophthalmol Scand 77:13-8. 1999
    ..To analyze the topography of normal and glaucomatous discs with the goal of developing improved strategies to discriminate between normal and glaucomatous eyes...
  96. ncbi Age, gender, IOP, refraction and optic disc topography in normal eyes. A cross-sectional study using raster and scanning laser tomography
    K G Gundersen
    Department of Ophthalmology, Malmo University Hospital, Sweden
    Acta Ophthalmol Scand 76:170-5. 1998
    ..To study the influence of age, gender, intraocular pressure and refraction on optic disc topography in normal subjects...
  97. ncbi Connective tissue structure of the tree shrew optic nerve and associated ageing changes
    Julie Albon
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 48:2134-44. 2007
    ..To identify the structure and composition of the tree shrew optic nerve to determine its potential as a model for glaucoma...
  98. ncbi Discrimination of glaucomatous optic neuropathy by digital stereoscopic analysis
    J E Morgan
    Department of Ophthalmology, University Hospital of Wales, Cardiff, United Kingdom
    Ophthalmology 112:855-62. 2005
    ..To evaluate the diagnostic power of a novel digital stereoscopic imaging system in the diagnosis of glaucomatous optic neuropathy...
  99. ncbi Optic disk cupping and electrocardiographic abnormalities in an American pedigree with Leber's hereditary optic neuropathy
    R G Ortiz
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia
    Am J Ophthalmol 113:561-6. 1992
    ..While the clinical significance of this magnitude of corrected QT prolongation is unknown, it may represent a systemic manifestation of the 11778 mutation. No electrocardiographic evidence of preexcitation syndromes was seen...
  100. ncbi Modelling the normal retinal nerve fibre layer thickness as measured by Stratus optical coherence tomography
    Jesper Leth Hougaard
    Department of Clinical Sciences, Ophthalmology, Malmo University Hospital, Lund University, 20502 Malmo, Sweden
    Graefes Arch Clin Exp Ophthalmol 244:1607-14. 2006
    ..With this perspective we evaluated the isolated and combined effects of factors potentially affecting the Stratus OCT RNFLT measurements in healthy subjects...
  101. ncbi Reproducibility of peripapillary retinal nerve fiber thickness measurements with stratus OCT in glaucomatous eyes
    Donald L Budenz
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmology 115:661-666.e4. 2008
    ..To determine the reproducibility of Stratus OCT peripapillary retinal nerve fiber layer (RNFL) measurements in glaucomatous eyes...

Research Grants62

  1. EARLY DETECTION OF GLAUCOMA DAMAGE
    Henry Jampel; Fiscal Year: 2004
    ..This assessment of the RTA and NFA will help to establish their utility as outcome measures for clinical management of glaucoma, epidemiological research, and clinical trials. ..
  2. OCULAR FUNCTIONS & PEPTIDE HORMONE SYSTEMS
    James Ryan; Fiscal Year: 1991
    ..the materials developed in 1), we will examine major tissues and fluids of the eye (notably retina, choroid, optic disk, optic nerve, iris, sclera, cornea, lens, ciliary body, vitreous and aqueous for their contents of the target ..
  3. UVEAL VASCULATURE: OPTIC NERVE MICROCIRCULATION
    George Cioffi; Fiscal Year: 2003
    ..of the supply arterioles, significant reduction in optic nerve blood flow, and significant increase in the optic disk cup volume. Preliminary application of the model in primates has demonstrated similar findings...
  4. Development of Retinal Receptive Fields
    NORBERTO GRZYWACZ; Fiscal Year: 2006
    ..degeneration, refsum disease, Leber hereditary optic neuropathy, optic-nerve hypoplasia, and drusen of the optic disk. Besides understanding pathologies, unraveling ganglion-cell plasticity may help with a promising technique for ..
  5. Molecular Mechanisms of Visual Thalamic Development
    Sam H Horng; Fiscal Year: 2010
    ..While axon guidance at the optic disk, tract and tectum has been well studied, little is known about mechanisms mediating ingrowth to thalamus...
  6. Diagnostic Innovations in Glaucoma: Clinical Electrophysiology
    Christopher Bowd; Fiscal Year: 2008
    ..Findings will be important to the clinical community for determining future evidence-based changes in standard of care for glaucoma diagnosis and monitoring. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  7. Quan11tification of Glaucomatous Optic Neuropathy
    Christopher Girkin; Fiscal Year: 2006
    ....
  8. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  9. PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGE
    Harry Quigley; Fiscal Year: 2008
    ..Candidate molecules for genetic susceptibility to glaucoma are likely to be identified. ..
  10. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2008
    ..abstract_text> ..
  11. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  12. Mapping RGC susceptibility alleles
    Robert Nickells; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Donald Budenz; Fiscal Year: 2008
    ....
  14. Transcriptional silencing in damaged retinal ganglia
    Robert Nickells; Fiscal Year: 2004
    ....
  15. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  16. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  17. CLEK-COORDINATING CENTER
    MAE GORDON; Fiscal Year: 2004
    ..The DCC is responsible for the study design, management of study data, monitoring the performance of the Reading Center and participating clinics, preparation of performance reports, analysis of data and presentation of results. ..
  18. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..abstract_text> ..
  19. Molecular and Cellular Mechanisms of Glaucoma
    OLEG KISSELEV; Fiscal Year: 2007
    ..abstract_text> ..
  20. Retinopathy in Chronic Renal Insufficiency
    Juan E Grunwald; Fiscal Year: 2010
    ....
  21. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Robert Weinreb; Fiscal Year: 2008
    ....
  22. Choroidal circulation in age related macular degeneration
    Juan Grunwald; Fiscal Year: 2008
    ..In addition, the knowledge gained through this investigation could also help in the identification of patients at risk of developing choroidal neovascularization, thus enabling earlier treatment. [unreadable] [unreadable] [unreadable]..
  23. EGPS/OHTS Collaborative Analysis
    MAE GORDON; Fiscal Year: 2005
    ..A Joint Committee will be responsible for implementing the study, overseeing the analyses and preparing presentations and publications. ..
  24. DATA COORDINATING CENTER FOR EARLY GLAUCOMA TRIAL
    M Leske; Fiscal Year: 2004
    ....
  25. Hereditary Benign Intraepithelial Dyskeratosis
    Wendi Lambert; Fiscal Year: 2005
    ..A limited number of extremely promising candidate genes will be transfected into an established cell culture system to test candidate genes on their ability form foci, which is consistent with the HBID phenotype. ..
  26. OCULAR HEMODYNAMICS IN GLAUCOMA
    Juan Grunwald; Fiscal Year: 2001
    ..If hemodynamic abnormalities are present, then attention can be focused on altering the optic nerve circulation as a means of treating glaucoma. ..
  27. GLAUCOMA SURGICAL OUTCOMES STUDY
    Henry Jampel; Fiscal Year: 2001
    ..The results of the study may allow physicians to reduce the morbidity of glaucoma surgery by altering their indications for surgery, surgical technique, and postoperative follow-up. ..
  28. VISUAL ADAPTATION LIMITS AND AGE-RELATED DISEASE
    Alvin Eisner; Fiscal Year: 2002
    ....
  29. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Henry Jampel; Fiscal Year: 2002
    ....
  30. Eicosanoids and the Outflow Pathways of the Eye
    Robert Weinreb; Fiscal Year: 2008
    ..The results of these studies have important implications for the discovery of new treatments for glaucoma and other vision-threatening eye diseases. ..
  31. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  32. PREVALENCE AND IMPACT OF GLAUCOMA AMONG THE VERY ELDERLY
    David Friedman; Fiscal Year: 2003
    ..Finally, the interactions between comorbidities (including cognitive deficits) and visual field loss will be explored. ..
  33. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  34. Glaucoma, Neurotrophins, and the Lamina Cribrosa
    ROBERT WORDINGER; Fiscal Year: 2004
    ..This study is significant because it will increase our knowledge of the role of NT in the human LC and may lead to alternative treatment modalities in glaucoma. ..
  35. Racial Variations in Optic Nerve Head Structure and Biomechanics
    J CRAWFORD contact DOWNS; Fiscal Year: 2011
    ....
  36. RETINAL ORGANIZATION OF COLOR PATHWAYS
    DAVID CALKINS; Fiscal Year: 2002
    ....
  37. Stabilized Adaptive Optics Imaging Laser Microsurgery
    Daniel Hammer; Fiscal Year: 2004
    ..abstract_text> ..
  38. Medical Advice from Glaucoma Informatics (MAGI)
    Michael Goldbaum; Fiscal Year: 2005
    ..In an effort to discover new and use useful information with unsupervised learning, we will mine our data in visual function and structural tests for glaucoma and in specific combinations of population groups. ..
  39. Testing therapeutic pathways in genetic glaucoma
    RICHARD LIBBY; Fiscal Year: 2004
    ..These experiments will provide insight into pathways responsible for pressure induced RGC degeneration. Additionally these experiments will provide insight into the location of neuronal insults in glaucoma. ..
  40. Pressure Induced Dynamic 3D Changes in Lamina Cribrosa
    Donald Brown; Fiscal Year: 2008
    ..This technique allows for direct measurement of the structural changes in the associated with glaucoma and has direct clinical relevance and application. [unreadable] [unreadable] [unreadable]..
  41. RETINAL AND CHOROIDAL BLOOD FLOW IMAGING
    Bahram Khoobehi; Fiscal Year: 2001
    ..With FCI, changes in blood flow rates in diabetic retinopathy and glaucoma might be determined, as well as the effect of consumption of vasoactive drugs. ..
  42. Neural Computations Underlying Visual Preception
    Michael A Paradiso; Fiscal Year: 2010
    ..This is the knowledge needed to work toward solutions to visual deficits. ..
  43. A Rapid Pupillometric Test for Glaucoma
    HARRY WYATT; Fiscal Year: 2005
    ..The relationship between the results of the test and the severity of the glaucomatous loss will be studied to determine the power of the test to provide useful information in a clinical setting. ..
  44. Molecular Characterization of Chick Retina during Refractive Development
    RICHARD ALAN STONE; Fiscal Year: 2010
    ....
  45. Structure-Function of the Retina With Neuroprotection
    Arthur Weber; Fiscal Year: 2009
    ....
  46. GLAUCOMA-CONNECTIVE TISSUE CHANGES IN OPTIC NERVE HEAD
    M Rosario Hernandez; Fiscal Year: 2008
    ..abstract_text> ..
  47. GENE EXPRESSION IN AXOTOMIZED RETINAL GANGLION CELLS
    Leonard Levin; Fiscal Year: 2004
    ..As many of these diseases (e.g., normal-tension glaucoma and ischemic optic neuropathy) are not easily treatable, determination of the regulation of cell destructive and protective mechanisms could lead to innovative new therapies. ..
  48. Perimetry and Psychophysics in Glaucoma
    Chris Johnson; Fiscal Year: 2006
    ..Together, these objectives will provide a better understanding of the underlying basis of early glaucomatous damage. ..
  49. Incidence of late macular degeneration in older women
    Anne Coleman; Fiscal Year: 2006
    ..This will allow the identification of women in SOF who have had progression of their ARM and developed late ARM since 1997 and 1998...
  50. MYOPIA AND OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 2004
    ..We hope that our studies will continue to lead to improved understanding of ocular growth and ultimately towards rational approaches to prevent refractive errors in children. ..
  51. Real-Time Three-Dimensional Motion Control Tracker
    Daniel Hammer; Fiscal Year: 2003
    ..After optimization, the Phase II instrument will be tested in a clinical ophthalmic program and the improvement in measurement of retinal features (e.g., nerve fiber layer thickness) will be quantified. ..
  52. In Vivo Measurement of Optic Nerve Axon Loss
    JAMES LINDSEY; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Hyperspectral Imaging of Oxygen Saturation in the ONH
    Bahram Khoobehi; Fiscal Year: 2006
    ..abstract_text> ..
  54. Telemedical Diagnosis of Retinopathy of Prematurity
    Michael Chiang; Fiscal Year: 2007
    ..Columbia University has a strong existing framework in medical information systems, telemedicine, and public health, which will be leveraged to complete this training and research program successfully. ..
  55. Cell-type Specific Genomics in the Aging Human Retina
    DAVID CALKINS; Fiscal Year: 2007
    ..The information generated will provide a basis for more extensive investigations of the mechanisms that mediate neuronal aging in the retina and brain. [unreadable] [unreadable] [unreadable]..
  56. Acquistion of a 600MHz NMR Spectrometer
    ARLENE ALBERT; Fiscal Year: 2003
    ..These instruments lack the resolution, sensitivity and available time to run the projects described above. These researchers currently travel a minimum of an hour to acquire the data needed on several funded projects. ..
  57. Optic Nerve Axon Loss and Metalloproteinases in Glaucoma
    JAMES LINDSEY; Fiscal Year: 2008
    ..These studies will investigate MMP-9 knockout mice and a drug that inhibits MMP activity. ..
  58. CIGTS-2 Optic Disc Reading Center
    Richard Parrish; Fiscal Year: 2005
    ..To provide the Coordinating Center with optic disc progression rates ..
  59. CLINICAL MEASUREMENTS OF OPTIC NERVE DAMAGE IN GLAUCOMA
    Joseph Caprioli; Fiscal Year: 2004
    ....
  60. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Anne L Coleman; Fiscal Year: 2008
    ....