pigment epithelium of eye

Summary

Summary: Epithelium in the retina, ciliary body, and iris containing pigment granules.

Top Publications

  1. ncbi The retinal pigment epithelium in visual function
    Olaf Strauss
    Bereich Experimentelle Ophthalmologie, Klinik und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Physiol Rev 85:845-81. 2005
  2. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
  3. ncbi Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
    Fong Qi Liang
    Retina Foundation of the Southwest, Anderson Vision Research Center, 9900 N Central Expressway, Suite 400, Dallas, TX 75231, USA
    Exp Eye Res 76:397-403. 2003
  4. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
  5. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
  6. ncbi Oxidative damage and protection of the RPE
    J Cai
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Prog Retin Eye Res 19:205-21. 2000
  7. pmc RPE65 is the isomerohydrolase in the retinoid visual cycle
    Gennadiy Moiseyev
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 102:12413-8. 2005
  8. ncbi ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
    K C Dunn
    Department of Ophthalmology, University of California, Davis 95616, USA
    Exp Eye Res 62:155-69. 1996
  9. ncbi Genetic defects in vitamin A metabolism of the retinal pigment epithelium
    Debra A Thompson
    Departments of Ophthalmology and Visual Sciences, and Biological Chemistry, University of Michigan Medical School, Ann Arbor, Mich, USA
    Dev Ophthalmol 37:141-54. 2003
  10. pmc Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium
    A D Marmorstein
    Department of Ophthalmic Research, Cole Eye Institute, and Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Proc Natl Acad Sci U S A 97:12758-63. 2000

Research Grants

  1. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 2001
  2. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
  3. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
  4. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
  5. Determinants of Phenotype in Retinal Pigment Epithelium
    Janice Burke; Fiscal Year: 2007
  6. BIOLOGICAL PROPERTIES OF RPE MELANIN
    Janice M Burke; Fiscal Year: 2010
  7. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
  8. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
  9. Gas6/Mertk mediated phagocytosis of OS by RPE cells
    Michael Hall; Fiscal Year: 2005
  10. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2003

Detail Information

Publications286 found, 100 shown here

  1. ncbi The retinal pigment epithelium in visual function
    Olaf Strauss
    Bereich Experimentelle Ophthalmologie, Klinik und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Physiol Rev 85:845-81. 2005
    ..On the other hand, mutations in genes expressed in photoreceptors can lead to degenerations of the RPE. Thus both tissues can be regarded as a functional unit where both interacting partners depend on each other...
  2. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  3. ncbi Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
    Fong Qi Liang
    Retina Foundation of the Southwest, Anderson Vision Research Center, 9900 N Central Expressway, Suite 400, Dallas, TX 75231, USA
    Exp Eye Res 76:397-403. 2003
    ..Thus, the susceptibility of mtDNA to oxidative damage in human RPE cells, together with the age-related decrease of cellular anti-oxidant system, provides the rationale for a mitochondria-based model of AMD...
  4. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
    ..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population...
  5. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    ....
  6. ncbi Oxidative damage and protection of the RPE
    J Cai
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Prog Retin Eye Res 19:205-21. 2000
    ..These results indicate that therapeutic or nutritional intervention to enhance the GSH antioxidant capacity of RPE may provide an effective way to prevent or treat AMD...
  7. pmc RPE65 is the isomerohydrolase in the retinoid visual cycle
    Gennadiy Moiseyev
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 102:12413-8. 2005
    ..Identification of the function of RPE65 will contribute to the understanding of the pathogenesis for retinal dystrophies associated with RPE65 mutations...
  8. ncbi ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
    K C Dunn
    Department of Ophthalmology, University of California, Davis 95616, USA
    Exp Eye Res 62:155-69. 1996
    ..Our results demonstrate that ARPE-19 has structural and functional properties characteristic of RPE cells in vivo and suggest that this cell line will be valuable for in vitro studies of retinal pigment epithelium physiology...
  9. ncbi Genetic defects in vitamin A metabolism of the retinal pigment epithelium
    Debra A Thompson
    Departments of Ophthalmology and Visual Sciences, and Biological Chemistry, University of Michigan Medical School, Ann Arbor, Mich, USA
    Dev Ophthalmol 37:141-54. 2003
    ..On the basis of these advances, it is hoped that patients with defects in RPE vitamin A metabolism will be among the first successfully treated by targeted therapies likely to become available in the near future...
  10. pmc Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium
    A D Marmorstein
    Department of Ophthalmic Research, Cole Eye Institute, and Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Proc Natl Acad Sci U S A 97:12758-63. 2000
    ..The basolateral plasma membrane localization of bestrophin suggests the possibility that bestrophin plays a role in generating the altered electrooculogram of individuals with Best disease...
  11. pmc miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networking
    Kenta Nakamura
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, United States of America
    PLoS ONE 5:e12058. 2010
    ..Among several miRNAs we have found that mir-148 shows an up-regulation in the ventral iris, while members of the let-7 family showed down-regulation in dorsal iris during dedifferentiation...
  12. ncbi Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery
    Michel Weber
    Laboratoire de Thérapie Génique, INSERM ERM01 05, CHU Hotel Dieu, Bât J Monnet, 30 Avenue J Monnet, 44035, Nantes Cedex 01, France
    Mol Ther 7:774-81. 2003
    ..Overall, these findings will have a practical impact on the development of future gene therapy trials of retinal diseases...
  13. ncbi Current concepts in the pathogenesis of age-related macular degeneration
    Marco A Zarbin
    Institute of Ophthalmology and Visual Science at the New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 90 Bergen Street, Suite 6100, Newark, NJ 07103 2499, USA
    Arch Ophthalmol 122:598-614. 2004
    ..To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD)...
  14. ncbi Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis
    Nataly Strunnikova
    National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1859, USA
    Invest Ophthalmol Vis Sci 45:3767-77. 2004
    ..To detail, by DNA microarrays and cellular structure labeling, the in vitro responses of retinal pigment epithelial (RPE) cells to a nonlethal dose of the oxidant agent hydroquinone (HQ)...
  15. pmc Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis
    Vanda S Lopes
    Molecular and Cellular Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 18:3914-27. 2007
    ..Together with the high levels of cathepsin D in immature melanosomes of the RPE, our results suggest that melanin deposition may protect the maturing melanosome from the activity of lumenal acid hydrolases...
  16. ncbi Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells
    Wei Feng
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    J Biol Chem 277:17016-22. 2002
    ..We conclude that Mertk likely functions directly in the RPE phagocytic process as a signaling molecule triggering outer segment ingestion...
  17. ncbi New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis
    M W Seeliger
    Retinal Electrodiagnostics Research Group, Department of Ophthalmology, University of Tubingen, Germany
    Nat Genet 29:70-4. 2001
    ..In general, the dissection of pathophysiological processes in animal models through the introduction of additional, selective mutations is a promising concept in functional genetics...
  18. pmc BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration
    Matthew W Grogg
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Nature 438:858-62. 2005
    ....
  19. ncbi The role of the retinal pigment epithelium: topographical variation and ageing changes
    M Boulton
    Department of Optometry and Vision Sciences, Cardiff University, UK
    Eye (Lond) 15:384-9. 2001
    ..While the aetiology of age-related macular degeneration is complex and is as yet unresolved, it is likely that accelerated ageing-like changes in the RPE play a fundamental role in the development of this condition...
  20. pmc Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors
    Silvia C Finnemann
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    EMBO J 22:4143-54. 2003
    ..In contrast, inhibition of FAK signaling diminishes MerTK phosphorylation. These results demonstrate that FAK provides an essential link between binding and engulfment mechanisms of integrin-mediated phagocytosis...
  21. ncbi Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium
    M M Jablonski
    Retinal Degeneration Research Center, Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Glia 35:14-25. 2001
    ....
  22. pmc Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells
    Monika Damek-Poprawa
    Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:10877-89. 2009
    ..Collectively, these studies suggest that MREG is required for lysosome maturation and support a role for MREG in intracellular trafficking...
  23. ncbi Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium
    Saaeha Rauz
    Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    Invest Ophthalmol Vis Sci 44:1643-51. 2003
    ..Sodium transport across the human ocular nonpigmented and pigmented ciliary epithelial bilayer (NPE-PE) is essential for aqueous humor production, but the expression of SGK1 and ENaC subunits remain to be defined...
  24. ncbi Intense light exposure changes the crystallin content in retina
    Hirokazu Sakaguchi
    Exp Eye Res 76:131-3. 2003
    ..Following light exposure, anti-alphaB-crystallin immunoreactivity was increased in rod outer segments and retinal pigment epithelium. These findings support a possible role for crystallins in protecting photoreceptors from light damage...
  25. ncbi Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice
    Hany Naggar
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    Invest Ophthalmol Vis Sci 43:556-63. 2002
    ..NO is elevated in diabetes, and therefore in the present study the alteration of RFT-1 activity in RPE under conditions of high glucose was investigated...
  26. ncbi A human opsin-related gene that encodes a retinaldehyde-binding protein
    D Shen
    Doheny Eye Institute, University of Southern California, School of Medicine, Los Angeles 90033
    Biochemistry 33:13117-25. 1994
    ..Since RGR binds all-trans-retinal preferentially, one of its functions may be to catalyze isomerization of the chromophore by a retinochrome-like mechanism...
  27. ncbi CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion
    Md Nawajes A Mandal
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
    Invest Ophthalmol Vis Sci 47:5505-13. 2006
    ..The purpose of this study was to characterize the spatial and temporal expression of the mouse Ctrp5 gene, determine tissue and subcellular localization, and study the effect of the S163R mutation...
  28. ncbi HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR
    Gregory I Liou
    Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Vis 8:494-501. 2002
    ..To understand molecular events that lead to retinal pigment epithelial (RPE) cell proliferation and migration during the early phases of proliferative vitreoretinopathy (PVR) in a rabbit model...
  29. ncbi Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse
    K M Bumsted
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA
    Invest Ophthalmol Vis Sci 41:903-8. 2000
    ..To determine a role for microphthalmia (mi) during eye development, the effects of an mi loss of function mutation on RPE and neural retinal were investigated in the mi/mi mouse...
  30. ncbi Matrix and the retinal pigment epithelium in proliferative retinal disease
    P Hiscott
    Department of Medicine, University of Liverpool, UK
    Prog Retin Eye Res 18:167-90. 1999
    ..The interactions present a number of potential therapeutic targets for the management of the disorder...
  31. ncbi Five recombinant simian immunodeficiency virus pseudotypes lead to exclusive transduction of retinal pigmented epithelium in rat
    Ghislaine Duisit
    Laboratoire de Thérapie Génique, CHU Hotel Dieu, Bât J Monnet, 30 Avenue J Monnet, 44035, Nantes Cedex 01, France
    Mol Ther 6:446-54. 2002
    ..Therefore, when a high level of GFP synthesis is achieved, replacement of enhanced GFP (egfp, Aequorea victoria) by a low-toxicity GFP (Renilla reniformis) cDNA is necessary to allow long-term expression...
  32. ncbi Immunocytochemical localization of NaK-ATPase isoforms in the rat and mouse ocular ciliary epithelium
    R K Wetzel
    Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, 149 23th Street, Charlestown, MA 02129
    Invest Ophthalmol Vis Sci 42:763-9. 2001
    ..This specialization in isoform expression implies that NaK-ATPase has distinct physiological functions in the two epithelia and that its activity is likely to be regulated by different mechanisms...
  33. ncbi Oxidative stress affects the junctional integrity of retinal pigment epithelial cells
    Tracey A Bailey
    Division of Pathology, Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:675-84. 2004
    ..Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration. The cell line ARPE-19 was therefore examined for response to oxidative stress and its effect on stress protein induction and junctional integrity...
  34. pmc Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein
    Daniel Gibbs
    Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla 92093 0912, USA
    Proc Natl Acad Sci U S A 100:6481-6. 2003
    ..Because the phagocytosis of photoreceptor disks by the RPE has been shown to be critical for photoreceptor cell viability, this defect likely contributes to the progressive blindness in USH1B...
  35. ncbi An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    G S Hageman
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
    Prog Retin Eye Res 20:705-32. 2001
    ..It is our hope that other investigators will test, validate and/or refute various aspects of this hypothesis, and in so doing, increase our overall understanding of the biological pathways associated with early AMD...
  36. ncbi Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells
    Paul E Milbury
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 48:2343-9. 2007
    ....
  37. pmc Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6
    Jason R Spence
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Mol Vis 13:57-65. 2007
    ..To elucidate the early cellular events that take place during induction of retina regeneration in the embryonic chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf...
  38. ncbi SOD2 knockdown mouse model of early AMD
    Verline Justilien
    Department of Molecular Genetics, University of Florida, Gainesville, Florida, USA
    Invest Ophthalmol Vis Sci 48:4407-20. 2007
    ..To test the hypothesis that oxidative injury to the retinal pigment epithelium (RPE) may lead to retinal damage similar to that associated with the early stages of age-related macular degeneration (AMD)...
  39. ncbi Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation
    Radha Ayyagari
    Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Invest Ophthalmol Vis Sci 46:3363-71. 2005
    ..To identify the gene responsible for a complex ocular phenotype of late-onset macular degeneration, long anterior zonules (LAZ), and elevated intraocular pressure (IOP) and to study its expression...
  40. pmc Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness
    J P Van Hooser
    Departments of Ophthalmology, Chemistry, and Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:8623-8. 2000
    ....
  41. ncbi Multiple functions of fibroblast growth factor-8 (FGF-8) in chick eye development
    A Vogel-Höpker
    Division of Anatomy, Department of Surgery, University of California, San Diego, 92093 0604, USA
    Mech Dev 94:25-36. 2000
    ..This is apparent by the expression of a lens specific marker, L-Maf, and by morphological changes of lens cells. These results suggest that FGF-8 plays a role in the initiation and differentiation of neural retina and lens...
  42. ncbi Differential macular and peripheral expression of bestrophin in human eyes and its implication for best disease
    Robert F Mullins
    Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Science, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 48:3372-80. 2007
    ..The nature of the vitelliform material and the reason the development of such lesions is usually restricted to the macula are two unsolved questions in the pathogenesis of this disorder...
  43. ncbi Proliferation and expression of progenitor and mature retinal phenotypes in the adult mammalian ciliary body after retinal ganglion cell injury
    Philip E B Nickerson
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 48:5266-75. 2007
    ..The authors sought to identify whether the predictable and time-dependent death of retinal ganglion cells (RGCs) results in activation of progenitor-like cells within the CB...
  44. ncbi Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor
    J Ortego
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Invest Ophthalmol Vis Sci 37:2759-67. 1996
    ..To study the expression of the neurotrophic pigment epithelium-derived factor (PEDF), a protein with neurotrophic and neuronal-survival activities, by the human ocular ciliary epithelium...
  45. ncbi A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration
    Zhenglin Yang
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 314:992-3. 2006
    ..We also found that drusen in the eyes of AMD patients were strongly immunolabeled with HTRA1 antibody. Together, these findings support a key role for HTRA1 in AMD susceptibility and identify a potential new pathway for AMD pathogenesis...
  46. ncbi Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration
    Antoinette C Lambooij
    Department of Ophthalmology, Erasmus Medical Center Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 44:2192-8. 2003
    ....
  47. ncbi Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogaster
    S M MacKenzie
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, The Australian National University, Canberra City, Australia
    Genetica 108:239-52. 2000
    ..Other functional implications of this new finding are discussed...
  48. ncbi Early-onset severe rod-cone dystrophy in young children with RPE65 mutations
    B Lorenz
    Department of Pediatric Ophthalmology and Ophthalmogenetics, University of Regensburg, Germany
    Invest Ophthalmol Vis Sci 41:2735-42. 2000
    ..To describe the ocular phenotype of patients with RPE65 mutations in infancy and young childhood...
  49. ncbi TGFbeta pathobiology in the eye
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 86:106-15. 2006
    ..The present paper reviews recent progress concerning the roles of TGFbeta signaling in the pathology of the eye...
  50. ncbi AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium
    Kourous A Rezai
    Department of Ophthalmology, Rush University Medical Center, Chicago, IL, USA
    Graefes Arch Clin Exp Ophthalmol 246:671-6. 2008
    ..The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated...
  51. ncbi Alterations of activity and intracellular distribution of the 20S proteasome in ageing retinal pigment epithelial cells
    Yue Li
    Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University and Eye Institute of PLA, Chang le Road 17, Xi an, Shaanxi 710032, China
    Exp Gerontol 43:1114-22. 2008
    ..Future researches on the mechanism of these alterations and the pathways to manipulate their effects are still strongly recommended...
  52. ncbi TGF-beta2-induced cell surface tissue transglutaminase increases adhesion and migration of RPE cells on fibronectin through the gelatin-binding domain
    Siegfried G Priglinger
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Invest Ophthalmol Vis Sci 45:955-63. 2004
    ..In the present study, the functional role of cell surface tissue transglutaminase (tTG) in adhesion and migration of RPE cells on fibronectin (Fn) and collagen type I (Col I) after stimulation with TGF-beta2 was investigated...
  53. ncbi Retinoid processing proteins in the ocular ciliary epithelium
    Mercedes Salvador-Silva
    Department of Ophthalmology and Visual Science, Yale University, New Haven, CT 06510, USA
    Mol Vis 11:356-65. 2005
    ....
  54. ncbi Is active glucose transport present in bovine ciliary body epithelium?
    Chu Yan Chan
    School of Optometry and Vision Sciences, Cardiff University, Wales, UK
    Am J Physiol Cell Physiol 292:C1087-93. 2007
    ..The elucidation of the exact function of SGLT2 in the bovine CBE may shed important light on the glucose transport and physiology of the BAB and inform future studies of glycemic control in relation to diabetic cataract formation...
  55. ncbi Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells
    Jong M Kim
    Department of Anatomy and Cell Biology, Dong A University College of Medicine, 3 1 Dongdaesin dong, Seo Gu, Busan, South Korea 602 714
    J Pharmacol Exp Ther 305:474-81. 2003
    ..Lactacystin-induced apoptosis in RPE-J cells is closely associated with an early mitochondrial hyperpolarization induced by intracellular alkalinization...
  56. ncbi Effective gene therapy with nonintegrating lentiviral vectors
    Rafael J Yáñez-Muñoz
    Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nat Med 12:348-53. 2006
    ..For therapeutic application to postmitotic tissues, this system substantially reduces the risk of insertional mutagenesis...
  57. ncbi Correlation of optical coherence tomography with angiography in retinal pigment epithelial detachment associated with age-related macular degeneration
    Taku Sato
    Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Retina 24:910-4. 2004
    ..To correlate optical coherence tomography (OCT) with angiographic signs of choroidal neovascularization (CNV) in retinal pigment epithelial detachment (PED) associated with age-related macular degeneration (ARMD)...
  58. ncbi Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells
    Reiko Udono-Fujimori
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Eur J Biochem 271:3076-84. 2004
    ..These results indicate that RPE cells maintain retinal homeostasis by repressing or inducing the expression of HO-1, depending on the microenvironment...
  59. ncbi Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta
    R K Kutty
    Laboratory of Retinal Cell, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Cell Physiol 159:371-8. 1994
    ..Our results demonstrate for the first time that HO-1 can be induced by an important cytokine, TGF-beta 1, causing an increase in the expression of both HO-1 message and protein in specific neuroepithelial and fibroblast cells...
  60. ncbi Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07
    Mei Chen
    Department of Ophthalmology, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 49:3699-706. 2008
    ..Morphologic and functional properties of this cell line have been characterized...
  61. ncbi Effect of indocyanine green and illumination on gene expression in human retinal pigment epithelial cells
    Hin Fai Yam
    Department of Ophthalmology and Visual Sciences, Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 44:370-7. 2003
    ..To investigate the biological effects of indocyanine green (ICG) and acute illumination on human retinal pigment epithelial (RPE) cells...
  62. pmc Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium
    Youwen Zhang
    Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85724, USA
    Mol Vis 16:200-6. 2010
    ..Best2 encodes a putative anion channel localized uniquely to the basolateral plasma membrane of non-pigmented epithelium cells in mice. In this study, we examine the localization of Best2 in the human eye...
  63. ncbi Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient mice
    Nasser M Qtaishat
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Invest Ophthalmol Vis Sci 44:1435-46. 2003
    ..The present study was undertaken to determine whether the Rpe65-deficient mouse exhibits an abnormal flux of retinoid between the systemic circulation and the eye tissues...
  64. ncbi Catecholaminergic regulation of Na-K-Cl cotransport in pigmented ciliary epithelium: differences between PE and NPE
    D H Hochgesand
    Beckman Vision Center, Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
    Exp Eye Res 72:1-12. 2001
    ..In contrast, dopamine was 28-fold more potent in NPE than in PE. The data suggest that both PE and NPE possess beta(2)adrenergic receptors, but only NPE cells possess dopamine D1 receptors linked to Na-K-Cl cotransport...
  65. ncbi Examining the proteins of functional retinal lipofuscin using proteomic analysis as a guide for understanding its origin
    Sarah Warburton
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
    Mol Vis 11:1122-34. 2005
    ..To elucidate the origins of biologically active retinal lipofuscin (RLF) by examining its protein composition...
  66. ncbi Active scatter factor (HGF/SF) in proliferative vitreoretinal disease
    M C Briggs
    St Paul s Eye Unit, Royal Liverpool University Hospital, UK
    Invest Ophthalmol Vis Sci 41:3085-94. 2000
    ..The role of HGF/SF in proliferative vitreoretinal disease was investigated...
  67. ncbi Direct comparison of the migration of three cell types involved in epiretinal membrane formation
    Penny A Hogg
    St Paul s Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 43:2749-57. 2002
    ....
  68. ncbi Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actin
    Jeffrey Sonsino
    Department of Biosciences, New England College of Optometry, Boston, MA 02118, USA
    Exp Eye Res 74:123-9. 2002
    ....
  69. ncbi Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro
    Yoko Miura
    Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka, Japan
    Jpn J Ophthalmol 47:268-75. 2003
    ..We investigated the effect of hepatocyte growth factor (HGF) on wound healing in RPE cells...
  70. pmc The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking
    Qing Zhang
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Hum Mol Genet 11:697-706. 2002
    ..Therefore, the mu gene is a member of the novel gene set that has evolved in higher eukaryotes to regulate the synthesis/function of highly specialized subcellular organelles such as melanosomes and platelet dense granules...
  71. ncbi Free radical mediated photoreceptor damage in uveitis
    N A Rao
    Doheny Eye Institute and Department of Ophthalmology and Pathology, University of Southern California, Los Angeles 90033 1088, USA
    Prog Retin Eye Res 19:41-68. 2000
    ..Either pharmacologically or chemically, up-regulation of RPP generation could help in preventing retinal degeneration in uveitis or other degenerative dis..
  72. pmc Recovery of visual functions in a mouse model of Leber congenital amaurosis
    J Preston Van Hooser
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:19173-82. 2002
    ....
  73. ncbi Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model
    A Auricchio
    Institute for Human Gene Therapy, Department of Molecular and Cellular Engineering, The Wistar Institute, Philadelphia, PA, USA
    Hum Mol Genet 10:3075-81. 2001
    ..We conclude that pseudotyping provides a useful means to manipulate viral vector cell targeting specificity as well as retinal transduction characteristics of vectors containing the same genome...
  74. ncbi Cytoskeletons of retinal pigment epithelial cells: interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteins
    K Owaribe
    Division of Membrane Biology and Biochemistry, German Cancer Research Center, Heidelberg
    Cell Tissue Res 254:301-15. 1988
    ....
  75. ncbi Regulated heat shock protein 27 expression in human retinal pigment epithelium
    N Strunnikova
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA
    Invest Ophthalmol Vis Sci 42:2130-8. 2001
    ..It is hypothesized that Hsp27 levels may play a role in disease states in the retina, such as ARMD...
  76. ncbi Production and accumulation of thrombospondin-1 in human retinal pigment epithelial cells
    H Miyajima-Uchida
    Department of Ophthalmology, School of Medicine, Fukuoka University, Japan
    Invest Ophthalmol Vis Sci 41:561-7. 2000
    ..To investigate the production and release of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, by human retinal pigment epithelial (RPE) cells to clarify the possible role of TSP-1 in maintaining intraocular angiogenesis...
  77. pmc Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium
    H Sun
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:9893-8. 1997
    ..These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds...
  78. ncbi Retinal remodeling triggered by photoreceptor degenerations
    Bryan W Jones
    John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132
    J Comp Neurol 464:1-16. 2003
    ..Although remodeling may constrain therapeutic intervals for molecular, cellular, or bionic rescue, it suggests that the neural retina may be more plastic than previously believed...
  79. pmc Oxidative damage-induced inflammation initiates age-related macular degeneration
    Joe G Hollyfield
    Cole Eye Institute i31, Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Nat Med 14:194-8. 2008
    ..This new model provides a platform for dissecting the molecular pathology of oxidative damage in the outer retina and the immune response contributing to AMD...
  80. ncbi Subretinal delivery of recombinant AAV serotype 8 vector in dogs results in gene transfer to neurons in the brain
    Knut Stieger
    INSERM U649, CHU Hotel Dieu, Nantes, France
    Mol Ther 16:916-23. 2008
    ..Vector sequences were detected in many parts of the brain, but chiefly in the contralateral hemisphere...
  81. pmc Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration
    Yutaka Imamura
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 103:11282-7. 2006
    ..In addition, these results demonstrate that the Sod1(-/-) mouse is a valuable animal model to study human age-related macular degeneration...
  82. ncbi Long-term preservation of cortically dependent visual function in RCS rats by transplantation
    P J Coffey
    Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK
    Nat Neurosci 5:53-6. 2002
    ....
  83. ncbi The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis
    M Vittoria Schiaffino
    DIBIT, Scientific Institute San Raffalele, Via Olgettina 58, 20132 Milan, Italy
    Pigment Cell Res 18:227-33. 2005
    ..These findings support previous hypotheses that GPCR-mediated signaling might also operate at the internal membranes in mammalian cells...
  84. ncbi Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor
    Ram Kannan
    The Arnold and Mabel Beckman Macular Research Center, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA
    Free Radic Biol Med 37:166-75. 2004
    ..The ability of HGF to attenuate these effects demonstrates its effectiveness as an antioxidant growth factor...
  85. ncbi Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium
    V L Bonilha
    Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Invest Ophthalmol Vis Sci 42:3274-82. 2001
    ..Identification of binding partners for ezrin, an actin-binding protein crucial for morphogenesis of apical microvilli and basolateral infoldings in RPE cells...
  86. ncbi Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Lab Invest 84:1245-58. 2004
    ..The results suggest that blocking the Smad3 pathway might be beneficial in prevention/treatment of PVR...
  87. pmc Oxidative damage and age-related macular degeneration
    B S Winkler
    Eye Research Institute, Oakland University, Rochester, MI 48309, USA
    Mol Vis 5:32. 1999
    ....
  88. pmc Acute retinal pigment epithelial tear following intravitreal bevacizumab (Avastin) injection for occult choroidal neovascularisation secondary to age related macular degeneration
    C H Meyer
    Br J Ophthalmol 90:1207-8. 2006
  89. ncbi Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama 641 0012, Japan
    Lab Invest 85:838-50. 2005
    ..Gene transfer of DN-p38MAPK attenuated the post-retinal detachment fibrotic reaction of the retinal pigment epithelium in vivo in mice, supporting its effectiveness in preventing/treating PVR...
  90. ncbi Adeno-associated virus-vectored gene therapy for retinal disease
    Astra Dinculescu
    Department of Ophthalmology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 16:649-63. 2005
    ..Because of the key role of the vasculature in maintaining a healthy retina, a summary of AAV gene therapy applications in animal models of retinal neovascular diseases is also included...
  91. ncbi Cotransport of H+, lactate, and H2O in porcine retinal pigment epithelial cells
    Steffen Hamann
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Exp Eye Res 76:493-504. 2003
    ....
  92. ncbi Taurine uptake by human retinal pigment epithelium: implications for the transport of small solutes between the choroid and the outer retina
    Jost Hillenkamp
    Department of Ophthalmology, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Invest Ophthalmol Vis Sci 45:4529-34. 2004
    ..To identify the rate limiting compartment in the pathway of taurine delivery from the choroidal blood supply to the outer retina composed by Bruch's-choroid (BC) and the RPE in the human older age group...
  93. pmc Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage
    Aniruddha C Amrite
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha 68198 5840, USA
    Invest Ophthalmol Vis Sci 47:1149-60. 2006
    ....
  94. ncbi Current understanding on the role of retinal pigment epithelium and its pigmentation
    U Schraermeyer
    Department of Vitreoretinal Surgery, University of Cologne, Germany
    Pigment Cell Res 12:219-36. 1999
    ..Most of these functions are not yet understood. Deficit of melanin pigment is associated with age-related macula degeneration, the leading cause of blindness...
  95. ncbi Retinal pigment epithelium of the rat express CD81, the target of the anti-proliferative antibody (TAPA)
    Eldon E Geisert
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Invest Ophthalmol Vis Sci 43:274-80. 2002
    ..The present study focuses on the role of CD81, the target of the anti-proliferative antibody (TAPA), in the regulation of the growth of retinal pigment epithelium (RPE)...
  96. ncbi Identification of novel bovine RPE and retinal genes by subtractive hybridization
    Shiwani Sharma
    Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia
    Mol Vis 8:251-8. 2002
    ..With this aim, we undertook a systematic effort to identify and begin characterization of such genes...
  97. ncbi Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrier
    Julia V Busik
    Department of Physiology, Michigan State University, 3155 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA
    Invest Ophthalmol Vis Sci 43:2356-63. 2002
    ....
  98. ncbi Persistent subretinal indocyanine green induces retinal pigment epithelium atrophy
    Akira Hirata
    Department of Ophthalmology, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Am J Ophthalmol 136:353-5. 2003
    ..To describe a case of a patient with macular hole with subretinal indocyanine green (ICG) during vitrectomy...
  99. ncbi Stimulation of L-type Ca(2+) channels by increase of intracellular InsP3 in rat retinal pigment epithelial cells
    Stefan Mergler
    Universitätsklinikum Charité der Humboldt Universität zu Berlin, Medizinische Klinik, Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany
    Exp Eye Res 74:29-40. 2002
    ..This is enabled by depletion of cytosolic Ca(2+)stores and tyrosine kinase-dependent activation of L-type channels...
  100. pmc SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration
    Emiko Kasahara
    Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Invest Ophthalmol Vis Sci 46:3426-34. 2005
    ....
  101. ncbi Suppression of cAMP-induced pigment granule aggregation in RPE by organic anion transport inhibitors
    D M Garcia
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Invest Ophthalmol Vis Sci 35:178-88. 1994
    ..To investigate the mechanism(s) by which intracellular cAMP levels are elevated to induce pigment granule aggregation in teleost retinal pigment epithelium (RPE)...

Research Grants63

  1. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 2001
    ..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
  2. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  3. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  4. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  5. Determinants of Phenotype in Retinal Pigment Epithelium
    Janice Burke; Fiscal Year: 2007
    ..To determine whether the anticipated loss of polarity in RPE cells leads to a clinically or morphologically detectable retinal degeneration. ..
  6. BIOLOGICAL PROPERTIES OF RPE MELANIN
    Janice M Burke; Fiscal Year: 2010
    ..The effects of age on melanosomes will also be studied to determine whether their ability to protect RPE cells from stress declines over time, which could contribute to diseases of the retina such as age-related macular degeneration. ..
  7. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
    ..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
  8. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
    ....
  9. Gas6/Mertk mediated phagocytosis of OS by RPE cells
    Michael Hall; Fiscal Year: 2005
    ..abstract_text> ..
  10. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2003
    ....
  11. TRANSMISSION ELECTRON MICROSCOPE
    Martin Katz; Fiscal Year: 2006
    ..Broadening the user base will help make the cost per user of maintaining the instrument as low as possible. [unreadable] [unreadable]..
  12. Alpha v beta 5 integrin in retinal pigment epithelium
    SILVIA FINNEMANN; Fiscal Year: 2004
    ..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
  13. The Integrin Ligand MFG-E8 and Photoreceptor Outer Segment Renewal.
    SILVIA FINNEMANN; Fiscal Year: 2007
    ....
  14. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
    ..abstract_text> ..
  15. METABOLIC AND HOMEOSTATIC MECHANISMS IN RETINA AND RPE
    Barry Winkler; Fiscal Year: 2003
    ..g., diamox) which have been reported to decrease retinal edema. A long-term goal of the second project is to understand better the nature of the interactions between the retina and RPE and factors regulating retinal detachment. ..
  16. Photoreceptor Cell Vulnerability and Glutathione Status
    Barry S Winkler; Fiscal Year: 2010
    ..These outcomes should help in the design of therapeutic treatments for photoreceptor degenerations that are linked to an inadequate antioxidative defense mechanism. ..
  17. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    ..The proposed studies will provide needed data on relationships among AMD, lipofuscin and macular pigment, estimate genetic contribution to the latter, and assist identification of individuals at greatest risk for vision loss. ..
  18. Subconjunctival Route to Prolong Corticosteroid Delivery
    Uday Kompella; Fiscal Year: 2005
    ..Based on this study, the PI will submit an RO-l proposal to assess subconjunctival budesonide-PLGA particles for the therapy of posterior segment disorders associated with inflammation and/or VEGF elevation. ..
  19. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  20. PROTEOMIC ANALYSIS OF AGE-RELATED MACULAR DEGENERATION
    TONGALP TEZEL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. Local Retinal Antigen Presentation
    DALE SANNES GREGERSON; Fiscal Year: 2010
    ..dendritic cells;or 2. MHC class II on subsets of immune cells in the retina. The ability of circulating antigen presenting cells, or their precursors, to replace these deficiencies in antigen presentation will be tested. ..
  22. Proteasome function in the aging retina
    Deborah A Ferrington; Fiscal Year: 2010
    ..Results from these experiments will help verify that immunoproteasome is an essential component of the retinal stress response and plays a fundamental role in maintaining retinal health. ..
  23. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  24. SMOKING-RELATED OXIDANTS,HTN, & DRY MACULAR DEGENERATION
    MARIA MARIN CASTANO; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  25. Proteomics of altered protein in macular degeneration
    DEBORAH FERRINGTON; Fiscal Year: 2006
    ..Identification of proteins that are uniquely altered will help provide valuable insight into the mechanism of AMD. ..
  26. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  27. Age-related epigenetic gene silencing in the RPE
    LEONARD HJELMELAND; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
    ..Conversely, we expect that estrogen's antioxidant action on the cell membrane will diminish MPO-induced blebbing and that activation of estrogen receptors will modify matrix molecule dysregulation. ..
  29. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  30. RPE65 IN RETINAL METABOLISM AND DEGENERATION
    Debra Thompson; Fiscal Year: 2005
    ..The long-term goals of this project are to elucidate the mechanisms by which RPE65 defects contribute to retinal degeneration, and to lay the groundwork for the development of therapeutic approaches to the disease. ..
  31. EPIGENETIC AGING OF THE OXIDATIVE STRESS RESPONSE IN THE MOUSE RPE
    Zeljka Smit McBride; Fiscal Year: 2010
    ..This work will eventually lead to the development of individualized treatments for blinding eye diseases. ..
  32. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2005
    ....
  33. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  34. SIGNIFICANCE OF IMMUNOLOGICAL SEQUESTRATION IN THE EYE
    DALE SANNES GREGERSON; Fiscal Year: 2010
    ..Aim II examines the possibility that local antigen presenting cells are limiting, in number and/or function, thus contributing to retinal immune ignorance and privilege. ..
  35. GENERATION OF MODELS FOR GENETIC HEARING LOSS
    DANA ORTEN; Fiscal Year: 2003
    ..Understanding disease processes will be the basis for designing and testing new treatments that could reduce or prevent human inherited hearing loss. ..
  36. CORNEAL ENDOTHELIAL CELL IMMUNOREGULATORY FACTORS
    DALE GREGERSON; Fiscal Year: 2003
    ..identify the activity(s) to learn if it is a known factor(s); and 3. if the activity has not already been described, continue characterization of the factor(s) and mechanism of action. ..
  37. Retinal Microvascular Characteristics/Vascular Disorders
    Ronald Klein; Fiscal Year: 2003
    ..abstract_text> ..
  38. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  39. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
  40. REDOX CONTROL OF FGF GENE EXPRESSION IN AGING RPE
    LEONARD HJELMELAND; Fiscal Year: 2002
    ..Our hypothesis provides a plausible link between cell death in the outer retina and the events of oxidative stress and RPE aging and may provide new approaches for the understanding and treatment of AMD. ..
  41. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  42. S100B Transgenic Mice and AMD
    Kimberly Howes; Fiscal Year: 2004
    ..abstract_text> ..
  43. Central Scotomas in AMD and Cortical Remapping
    Janet Sunness; Fiscal Year: 2005
    ....
  44. GLUTAMINE AND BREAST CANCER PROLIFERATION AND TREATMENT
    STEVE ABCOUWER; Fiscal Year: 2002
    ..This may provide the basis for novel metabolically directed cancer therapies. ..
  45. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..
  46. SMCT1 & SMCT2: expression in retina & relevance to diabetic retinopathy
    Pamela Martin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  47. Cellular and Molecular Mechanisms Regulating Photoreceptor Morphology
    ABIGAIL JENSEN; Fiscal Year: 2008
    ..This raises the interesting question as to whether this phenomenon is causal or whether compromised or sick photoreceptors are unable to maintain their inner and outer segments. ..
  48. CHLORIDE TRANSPORT IN HUMAN CILIARY EPITHELIUM
    Richard Crook; Fiscal Year: 2001
    ..He also proposes to test the hypothesis that other hormones known to either increase or decrease aqueous inflow might exert their effects through modulation of Na+, K+, Cl cotransport activity. ..
  49. PHOTOCHEMISTRY OF HUMAN RETINAL LIPOFUSCIN
    ELIZABETH GAILLARD; Fiscal Year: 2002
    ..Information from these studies may allow for the development of protocols to slow down or stop the processes that lead to irreversible damage to the human retina ..
  50. EYE GROWTH DURING INFANCY
    Scott Lambert; Fiscal Year: 2001
    ..In addition, by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth which occurs in certain pathological conditions such as retinopathy of prematurity. ..
  51. Prevention of Photoreceptor Degeneration
    Raymond Lund; Fiscal Year: 2005
    ..abstract_text> ..
  52. Actin and myosins in organelle motility
    Christina King Smith; Fiscal Year: 2003
    ..The proposed research will contribute to a better understanding of actin-dependent organelle motility, a universal characteristic of eukaryotic cells. ..
  53. Genetic model of retinal pigment epithelium degeneration
    Douglas Vollrath; Fiscal Year: 2005
    ....
  54. Expression and Regulation of Retinal Angiotensin II
    Preenie Senanayake; Fiscal Year: 2005
    ..Ultimately retinal Ang receptors could be specifically targeted with selective therapeutic agents to prevent the development of proliferative diabetic retinopathy. ..
  55. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Robert Ritch; Fiscal Year: 2003
    ....
  56. Dyslipidemia and retinal endothelial cell dysfunction
    Julia Busik; Fiscal Year: 2004
    ..The outcome of this work will lead to a better understanding of how diabetic dyslipidemia contributes to altered hRVE cell phenotype and the onset and progression of diabetic retinopathy. ..
  57. Genoplasty in Ocular Gene Therapy
    JOHN NICKERSON; Fiscal Year: 2004
    ..abstract_text> ..
  58. CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINAS
    Catherine Bowes Rickman; Fiscal Year: 2005
    ..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
  59. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  60. Murine Age-related Macular Degeneration: Model of Known Human Risk Factors
    Catherine Bowes Rickman; Fiscal Year: 2007
    ..Analysis of these animals will provide insight into the pathogenesis of AMD as well as a means to separate the relative contribution and degenerative effects of specific risk factors. [unreadable] [unreadable] [unreadable]..
  61. p27Kip1 and RPE Cell Cycle
    DENNIS DEFOE; Fiscal Year: 2003
    ..The alternative hypothesis that the thickening of the RPE layer is due to an increase in cell size will be examined by morphometric analysis of images obtained by confocal microscopy. ..
  62. p27(Kip1) and Retinal Attachment
    DENNIS DEFOE; Fiscal Year: 2008
    ..To test this, the Cre-lox system for conditional gene targeting will be implemented to ablate the p27(Kip1) gene selectively in RPE cells. [unreadable] [unreadable] [unreadable]..
  63. Culture and Transplantation of Human Retinal Spheres
    DAVID GAMM; Fiscal Year: 2008
    ..Together, these experiments are designed to build on recent advances in the burgeoning field of stem cell biology and apply them to the basic and clinical science of ophthalmology. ..