Genomes and Genes
pigment epithelium of eye
Summary: Epithelium in the retina, ciliary body, and iris containing pigment granules.
Publications286 found, 100 shown here
- The retinal pigment epithelium in visual functionOlaf Strauss
Bereich Experimentelle Ophthalmologie, Klinik und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Physiol Rev 85:845-81. 2005..On the other hand, mutations in genes expressed in photoreceptors can lead to degenerations of the RPE. Thus both tissues can be regarded as a functional unit where both interacting partners depend on each other...
- Complement factor H polymorphism in age-related macular degenerationRobert J Klein
Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 308:385-9. 2005..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
- Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degenerationFong Qi Liang
Retina Foundation of the Southwest, Anderson Vision Research Center, 9900 N Central Expressway, Suite 400, Dallas, TX 75231, USA
Exp Eye Res 76:397-403. 2003..Thus, the susceptibility of mtDNA to oxidative damage in human RPE cells, together with the age-related decrease of cellular anti-oxidant system, provides the rationale for a mitochondria-based model of AMD...
- A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationGregory S Hageman
Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
Proc Natl Acad Sci U S A 102:7227-32. 2005..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population...
- Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITFM Nguyen
Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Development 127:3581-91. 2000....
- Oxidative damage and protection of the RPEJ Cai
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
Prog Retin Eye Res 19:205-21. 2000..These results indicate that therapeutic or nutritional intervention to enhance the GSH antioxidant capacity of RPE may provide an effective way to prevent or treat AMD...
- RPE65 is the isomerohydrolase in the retinoid visual cycleGennadiy Moiseyev
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Proc Natl Acad Sci U S A 102:12413-8. 2005..Identification of the function of RPE65 will contribute to the understanding of the pathogenesis for retinal dystrophies associated with RPE65 mutations...
- ARPE-19, a human retinal pigment epithelial cell line with differentiated propertiesK C Dunn
Department of Ophthalmology, University of California, Davis 95616, USA
Exp Eye Res 62:155-69. 1996..Our results demonstrate that ARPE-19 has structural and functional properties characteristic of RPE cells in vivo and suggest that this cell line will be valuable for in vitro studies of retinal pigment epithelium physiology...
- Genetic defects in vitamin A metabolism of the retinal pigment epitheliumDebra A Thompson
Departments of Ophthalmology and Visual Sciences, and Biological Chemistry, University of Michigan Medical School, Ann Arbor, Mich, USA
Dev Ophthalmol 37:141-54. 2003..On the basis of these advances, it is hoped that patients with defects in RPE vitamin A metabolism will be among the first successfully treated by targeted therapies likely to become available in the near future...
- Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epitheliumA D Marmorstein
Department of Ophthalmic Research, Cole Eye Institute, and Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
Proc Natl Acad Sci U S A 97:12758-63. 2000..The basolateral plasma membrane localization of bestrophin suggests the possibility that bestrophin plays a role in generating the altered electrooculogram of individuals with Best disease...
- miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networkingKenta Nakamura
Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, United States of America
PLoS ONE 5:e12058. 2010..Among several miRNAs we have found that mir-148 shows an up-regulation in the ventral iris, while members of the let-7 family showed down-regulation in dorsal iris during dedifferentiation...
- Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal deliveryMichel Weber
Laboratoire de Thérapie Génique, INSERM ERM01 05, CHU Hotel Dieu, Bât J Monnet, 30 Avenue J Monnet, 44035, Nantes Cedex 01, France
Mol Ther 7:774-81. 2003..Overall, these findings will have a practical impact on the development of future gene therapy trials of retinal diseases...
- Current concepts in the pathogenesis of age-related macular degenerationMarco A Zarbin
Institute of Ophthalmology and Visual Science at the New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 90 Bergen Street, Suite 6100, Newark, NJ 07103 2499, USA
Arch Ophthalmol 122:598-614. 2004..To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD)...
- Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysisNataly Strunnikova
National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1859, USA
Invest Ophthalmol Vis Sci 45:3767-77. 2004..To detail, by DNA microarrays and cellular structure labeling, the in vitro responses of retinal pigment epithelial (RPE) cells to a nonlethal dose of the oxidant agent hydroquinone (HQ)...
- Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesisVanda S Lopes
Molecular and Cellular Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
Mol Biol Cell 18:3914-27. 2007..Together with the high levels of cathepsin D in immature melanosomes of the RPE, our results suggest that melanin deposition may protect the maturing melanosome from the activity of lumenal acid hydrolases...
- Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cellsWei Feng
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
J Biol Chem 277:17016-22. 2002..We conclude that Mertk likely functions directly in the RPE phagocytic process as a signaling molecule triggering outer segment ingestion...
- New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosisM W Seeliger
Retinal Electrodiagnostics Research Group, Department of Ophthalmology, University of Tubingen, Germany
Nat Genet 29:70-4. 2001..In general, the dissection of pathophysiological processes in animal models through the introduction of additional, selective mutations is a promising concept in functional genetics...
- BMP inhibition-driven regulation of six-3 underlies induction of newt lens regenerationMatthew W Grogg
Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
Nature 438:858-62. 2005....
- The role of the retinal pigment epithelium: topographical variation and ageing changesM Boulton
Department of Optometry and Vision Sciences, Cardiff University, UK
Eye (Lond) 15:384-9. 2001..While the aetiology of age-related macular degeneration is complex and is as yet unresolved, it is likely that accelerated ageing-like changes in the RPE play a fundamental role in the development of this condition...
- Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptorsSilvia C Finnemann
Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
EMBO J 22:4143-54. 2003..In contrast, inhibition of FAK signaling diminishes MerTK phosphorylation. These results demonstrate that FAK provides an essential link between binding and engulfment mechanisms of integrin-mediated phagocytosis...
- Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epitheliumM M Jablonski
Retinal Degeneration Research Center, Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Glia 35:14-25. 2001....
- Melanoregulin (MREG) modulates lysosome function in pigment epithelial cellsMonika Damek-Poprawa
Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 284:10877-89. 2009..Collectively, these studies suggest that MREG is required for lysosome maturation and support a role for MREG in intracellular trafficking...
- Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epitheliumSaaeha Rauz
Academic Unit of Ophthalmology, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
Invest Ophthalmol Vis Sci 44:1643-51. 2003..Sodium transport across the human ocular nonpigmented and pigmented ciliary epithelial bilayer (NPE-PE) is essential for aqueous humor production, but the expression of SGK1 and ENaC subunits remain to be defined...
- Intense light exposure changes the crystallin content in retinaHirokazu Sakaguchi
Exp Eye Res 76:131-3. 2003..Following light exposure, anti-alphaB-crystallin immunoreactivity was increased in rod outer segments and retinal pigment epithelium. These findings support a possible role for crystallins in protecting photoreceptors from light damage...
- Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic miceHany Naggar
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
Invest Ophthalmol Vis Sci 43:556-63. 2002..NO is elevated in diabetes, and therefore in the present study the alteration of RFT-1 activity in RPE under conditions of high glucose was investigated...
- A human opsin-related gene that encodes a retinaldehyde-binding proteinD Shen
Doheny Eye Institute, University of Southern California, School of Medicine, Los Angeles 90033
Biochemistry 33:13117-25. 1994..Since RGR binds all-trans-retinal preferentially, one of its functions may be to catalyze isomerization of the chromophore by a retinochrome-like mechanism...
- CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretionMd Nawajes A Mandal
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
Invest Ophthalmol Vis Sci 47:5505-13. 2006..The purpose of this study was to characterize the spatial and temporal expression of the mouse Ctrp5 gene, determine tissue and subcellular localization, and study the effect of the S163R mutation...
- HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVRGregory I Liou
Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
Mol Vis 8:494-501. 2002..To understand molecular events that lead to retinal pigment epithelial (RPE) cell proliferation and migration during the early phases of proliferative vitreoretinopathy (PVR) in a rabbit model...
- Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouseK M Bumsted
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA
Invest Ophthalmol Vis Sci 41:903-8. 2000..To determine a role for microphthalmia (mi) during eye development, the effects of an mi loss of function mutation on RPE and neural retinal were investigated in the mi/mi mouse...
- Matrix and the retinal pigment epithelium in proliferative retinal diseaseP Hiscott
Department of Medicine, University of Liverpool, UK
Prog Retin Eye Res 18:167-90. 1999..The interactions present a number of potential therapeutic targets for the management of the disorder...
- Five recombinant simian immunodeficiency virus pseudotypes lead to exclusive transduction of retinal pigmented epithelium in ratGhislaine Duisit
Laboratoire de Thérapie Génique, CHU Hotel Dieu, Bât J Monnet, 30 Avenue J Monnet, 44035, Nantes Cedex 01, France
Mol Ther 6:446-54. 2002..Therefore, when a high level of GFP synthesis is achieved, replacement of enhanced GFP (egfp, Aequorea victoria) by a low-toxicity GFP (Renilla reniformis) cDNA is necessary to allow long-term expression...
- Immunocytochemical localization of NaK-ATPase isoforms in the rat and mouse ocular ciliary epitheliumR K Wetzel
Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, 149 23th Street, Charlestown, MA 02129
Invest Ophthalmol Vis Sci 42:763-9. 2001..This specialization in isoform expression implies that NaK-ATPase has distinct physiological functions in the two epithelia and that its activity is likely to be regulated by different mechanisms...
- Oxidative stress affects the junctional integrity of retinal pigment epithelial cellsTracey A Bailey
Division of Pathology, Institute of Ophthalmology, University College London, London, United Kingdom
Invest Ophthalmol Vis Sci 45:675-84. 2004..Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration. The cell line ARPE-19 was therefore examined for response to oxidative stress and its effect on stress protein induction and junctional integrity...
- Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B proteinDaniel Gibbs
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla 92093 0912, USA
Proc Natl Acad Sci U S A 100:6481-6. 2003..Because the phagocytosis of photoreceptor disks by the RPE has been shown to be critical for photoreceptor cell viability, this defect likely contributes to the progressive blindness in USH1B...
- An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degenerationG S Hageman
Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
Prog Retin Eye Res 20:705-32. 2001..It is our hope that other investigators will test, validate and/or refute various aspects of this hypothesis, and in so doing, increase our overall understanding of the biological pathways associated with early AMD...
- Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cellsPaul E Milbury
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Invest Ophthalmol Vis Sci 48:2343-9. 2007....
- Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6Jason R Spence
Department of Zoology, Miami University, Oxford, Ohio 45056, USA
Mol Vis 13:57-65. 2007..To elucidate the early cellular events that take place during induction of retina regeneration in the embryonic chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf...
- SOD2 knockdown mouse model of early AMDVerline Justilien
Department of Molecular Genetics, University of Florida, Gainesville, Florida, USA
Invest Ophthalmol Vis Sci 48:4407-20. 2007..To test the hypothesis that oxidative injury to the retinal pigment epithelium (RPE) may lead to retinal damage similar to that associated with the early stages of age-related macular degeneration (AMD)...
- Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutationRadha Ayyagari
Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
Invest Ophthalmol Vis Sci 46:3363-71. 2005..To identify the gene responsible for a complex ocular phenotype of late-onset macular degeneration, long anterior zonules (LAZ), and elevated intraocular pressure (IOP) and to study its expression...
- Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindnessJ P Van Hooser
Departments of Ophthalmology, Chemistry, and Pharmacology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 97:8623-8. 2000....
- Multiple functions of fibroblast growth factor-8 (FGF-8) in chick eye developmentA Vogel-Höpker
Division of Anatomy, Department of Surgery, University of California, San Diego, 92093 0604, USA
Mech Dev 94:25-36. 2000..This is apparent by the expression of a lens specific marker, L-Maf, and by morphological changes of lens cells. These results suggest that FGF-8 plays a role in the initiation and differentiation of neural retina and lens...
- Differential macular and peripheral expression of bestrophin in human eyes and its implication for best diseaseRobert F Mullins
Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Science, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Invest Ophthalmol Vis Sci 48:3372-80. 2007..The nature of the vitelliform material and the reason the development of such lesions is usually restricted to the macula are two unsolved questions in the pathogenesis of this disorder...
- Proliferation and expression of progenitor and mature retinal phenotypes in the adult mammalian ciliary body after retinal ganglion cell injuryPhilip E B Nickerson
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
Invest Ophthalmol Vis Sci 48:5266-75. 2007..The authors sought to identify whether the predictable and time-dependent death of retinal ganglion cells (RGCs) results in activation of progenitor-like cells within the CB...
- Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humorJ Ortego
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Invest Ophthalmol Vis Sci 37:2759-67. 1996..To study the expression of the neurotrophic pigment epithelium-derived factor (PEDF), a protein with neurotrophic and neuronal-survival activities, by the human ocular ciliary epithelium...
- A variant of the HTRA1 gene increases susceptibility to age-related macular degenerationZhenglin Yang
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Science 314:992-3. 2006..We also found that drusen in the eyes of AMD patients were strongly immunolabeled with HTRA1 antibody. Together, these findings support a key role for HTRA1 in AMD susceptibility and identify a potential new pathway for AMD pathogenesis...
- Insulin-like growth factor-I and its receptor in neovascular age-related macular degenerationAntoinette C Lambooij
Department of Ophthalmology, Erasmus Medical Center Rotterdam, The Netherlands
Invest Ophthalmol Vis Sci 44:2192-8. 2003....
- Sub-cellular localisation of the white/scarlet ABC transporter to pigment granule membranes within the compound eye of Drosophila melanogasterS M MacKenzie
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, The Australian National University, Canberra City, Australia
Genetica 108:239-52. 2000..Other functional implications of this new finding are discussed...
- Early-onset severe rod-cone dystrophy in young children with RPE65 mutationsB Lorenz
Department of Pediatric Ophthalmology and Ophthalmogenetics, University of Regensburg, Germany
Invest Ophthalmol Vis Sci 41:2735-42. 2000..To describe the ocular phenotype of patients with RPE65 mutations in infancy and young childhood...
- TGFbeta pathobiology in the eyeShizuya Saika
Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
Lab Invest 86:106-15. 2006..The present paper reviews recent progress concerning the roles of TGFbeta signaling in the pathology of the eye...
- AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epitheliumKourous A Rezai
Department of Ophthalmology, Rush University Medical Center, Chicago, IL, USA
Graefes Arch Clin Exp Ophthalmol 246:671-6. 2008..The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated...
- Alterations of activity and intracellular distribution of the 20S proteasome in ageing retinal pigment epithelial cellsYue Li
Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University and Eye Institute of PLA, Chang le Road 17, Xi an, Shaanxi 710032, China
Exp Gerontol 43:1114-22. 2008..Future researches on the mechanism of these alterations and the pathways to manipulate their effects are still strongly recommended...
- TGF-beta2-induced cell surface tissue transglutaminase increases adhesion and migration of RPE cells on fibronectin through the gelatin-binding domainSiegfried G Priglinger
Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
Invest Ophthalmol Vis Sci 45:955-63. 2004..In the present study, the functional role of cell surface tissue transglutaminase (tTG) in adhesion and migration of RPE cells on fibronectin (Fn) and collagen type I (Col I) after stimulation with TGF-beta2 was investigated...
- Retinoid processing proteins in the ocular ciliary epitheliumMercedes Salvador-Silva
Department of Ophthalmology and Visual Science, Yale University, New Haven, CT 06510, USA
Mol Vis 11:356-65. 2005....
- Is active glucose transport present in bovine ciliary body epithelium?Chu Yan Chan
School of Optometry and Vision Sciences, Cardiff University, Wales, UK
Am J Physiol Cell Physiol 292:C1087-93. 2007..The elucidation of the exact function of SGLT2 in the bovine CBE may shed important light on the glucose transport and physiology of the BAB and inform future studies of glycemic control in relation to diabetic cataract formation...
- Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cellsJong M Kim
Department of Anatomy and Cell Biology, Dong A University College of Medicine, 3 1 Dongdaesin dong, Seo Gu, Busan, South Korea 602 714
J Pharmacol Exp Ther 305:474-81. 2003..Lactacystin-induced apoptosis in RPE-J cells is closely associated with an early mitochondrial hyperpolarization induced by intracellular alkalinization...
- Effective gene therapy with nonintegrating lentiviral vectorsRafael J Yáñez-Muñoz
Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
Nat Med 12:348-53. 2006..For therapeutic application to postmitotic tissues, this system substantially reduces the risk of insertional mutagenesis...
- Correlation of optical coherence tomography with angiography in retinal pigment epithelial detachment associated with age-related macular degenerationTaku Sato
Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan
Retina 24:910-4. 2004..To correlate optical coherence tomography (OCT) with angiographic signs of choroidal neovascularization (CNV) in retinal pigment epithelial detachment (PED) associated with age-related macular degeneration (ARMD)...
- Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cellsReiko Udono-Fujimori
Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
Eur J Biochem 271:3076-84. 2004..These results indicate that RPE cells maintain retinal homeostasis by repressing or inducing the expression of HO-1, depending on the microenvironment...
- Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-betaR K Kutty
Laboratory of Retinal Cell, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
J Cell Physiol 159:371-8. 1994..Our results demonstrate for the first time that HO-1 can be induced by an important cytokine, TGF-beta 1, causing an increase in the expression of both HO-1 message and protein in specific neuroepithelial and fibroblast cells...
- Characterization of a spontaneous mouse retinal pigment epithelial cell line B6-RPE07Mei Chen
Department of Ophthalmology, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Scotland, United Kingdom
Invest Ophthalmol Vis Sci 49:3699-706. 2008..Morphologic and functional properties of this cell line have been characterized...
- Effect of indocyanine green and illumination on gene expression in human retinal pigment epithelial cellsHin Fai Yam
Department of Ophthalmology and Visual Sciences, Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong Kong
Invest Ophthalmol Vis Sci 44:370-7. 2003..To investigate the biological effects of indocyanine green (ICG) and acute illumination on human retinal pigment epithelial (RPE) cells...
- Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epitheliumYouwen Zhang
Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85724, USA
Mol Vis 16:200-6. 2010..Best2 encodes a putative anion channel localized uniquely to the basolateral plasma membrane of non-pigmented epithelium cells in mice. In this study, we examine the localization of Best2 in the human eye...
- Acute radiolabeling of retinoids in eye tissues of normal and rpe65-deficient miceNasser M Qtaishat
Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Invest Ophthalmol Vis Sci 44:1435-46. 2003..The present study was undertaken to determine whether the Rpe65-deficient mouse exhibits an abnormal flux of retinoid between the systemic circulation and the eye tissues...
- Catecholaminergic regulation of Na-K-Cl cotransport in pigmented ciliary epithelium: differences between PE and NPED H Hochgesand
Beckman Vision Center, Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
Exp Eye Res 72:1-12. 2001..In contrast, dopamine was 28-fold more potent in NPE than in PE. The data suggest that both PE and NPE possess beta(2)adrenergic receptors, but only NPE cells possess dopamine D1 receptors linked to Na-K-Cl cotransport...
- Examining the proteins of functional retinal lipofuscin using proteomic analysis as a guide for understanding its originSarah Warburton
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
Mol Vis 11:1122-34. 2005..To elucidate the origins of biologically active retinal lipofuscin (RLF) by examining its protein composition...
- Active scatter factor (HGF/SF) in proliferative vitreoretinal diseaseM C Briggs
St Paul s Eye Unit, Royal Liverpool University Hospital, UK
Invest Ophthalmol Vis Sci 41:3085-94. 2000..The role of HGF/SF in proliferative vitreoretinal disease was investigated...
- Direct comparison of the migration of three cell types involved in epiretinal membrane formationPenny A Hogg
St Paul s Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool, United Kingdom
Invest Ophthalmol Vis Sci 43:2749-57. 2002....
- Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actinJeffrey Sonsino
Department of Biosciences, New England College of Optometry, Boston, MA 02118, USA
Exp Eye Res 74:123-9. 2002....
- Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitroYoko Miura
Department of Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka, Japan
Jpn J Ophthalmol 47:268-75. 2003..We investigated the effect of hepatocyte growth factor (HGF) on wound healing in RPE cells...
- The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle traffickingQing Zhang
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Hum Mol Genet 11:697-706. 2002..Therefore, the mu gene is a member of the novel gene set that has evolved in higher eukaryotes to regulate the synthesis/function of highly specialized subcellular organelles such as melanosomes and platelet dense granules...
- Free radical mediated photoreceptor damage in uveitisN A Rao
Doheny Eye Institute and Department of Ophthalmology and Pathology, University of Southern California, Los Angeles 90033 1088, USA
Prog Retin Eye Res 19:41-68. 2000..Either pharmacologically or chemically, up-regulation of RPP generation could help in preventing retinal degeneration in uveitis or other degenerative dis..
- Recovery of visual functions in a mouse model of Leber congenital amaurosisJ Preston Van Hooser
Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 277:19173-82. 2002....
- Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a modelA Auricchio
Institute for Human Gene Therapy, Department of Molecular and Cellular Engineering, The Wistar Institute, Philadelphia, PA, USA
Hum Mol Genet 10:3075-81. 2001..We conclude that pseudotyping provides a useful means to manipulate viral vector cell targeting specificity as well as retinal transduction characteristics of vectors containing the same genome...
- Cytoskeletons of retinal pigment epithelial cells: interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteinsK Owaribe
Division of Membrane Biology and Biochemistry, German Cancer Research Center, Heidelberg
Cell Tissue Res 254:301-15. 1988....
- Regulated heat shock protein 27 expression in human retinal pigment epitheliumN Strunnikova
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA
Invest Ophthalmol Vis Sci 42:2130-8. 2001..It is hypothesized that Hsp27 levels may play a role in disease states in the retina, such as ARMD...
- Production and accumulation of thrombospondin-1 in human retinal pigment epithelial cellsH Miyajima-Uchida
Department of Ophthalmology, School of Medicine, Fukuoka University, Japan
Invest Ophthalmol Vis Sci 41:561-7. 2000..To investigate the production and release of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, by human retinal pigment epithelial (RPE) cells to clarify the possible role of TSP-1 in maintaining intraocular angiogenesis...
- Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epitheliumH Sun
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 94:9893-8. 1997..These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds...
- Retinal remodeling triggered by photoreceptor degenerationsBryan W Jones
John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132
J Comp Neurol 464:1-16. 2003..Although remodeling may constrain therapeutic intervals for molecular, cellular, or bionic rescue, it suggests that the neural retina may be more plastic than previously believed...
- Oxidative damage-induced inflammation initiates age-related macular degenerationJoe G Hollyfield
Cole Eye Institute i31, Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
Nat Med 14:194-8. 2008..This new model provides a platform for dissecting the molecular pathology of oxidative damage in the outer retina and the immune response contributing to AMD...
- Subretinal delivery of recombinant AAV serotype 8 vector in dogs results in gene transfer to neurons in the brainKnut Stieger
INSERM U649, CHU Hotel Dieu, Nantes, France
Mol Ther 16:916-23. 2008..Vector sequences were detected in many parts of the brain, but chiefly in the contralateral hemisphere...
- Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degenerationYutaka Imamura
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Proc Natl Acad Sci U S A 103:11282-7. 2006..In addition, these results demonstrate that the Sod1(-/-) mouse is a valuable animal model to study human age-related macular degeneration...
- Long-term preservation of cortically dependent visual function in RCS rats by transplantationP J Coffey
Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK
Nat Neurosci 5:53-6. 2002....
- The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesisM Vittoria Schiaffino
DIBIT, Scientific Institute San Raffalele, Via Olgettina 58, 20132 Milan, Italy
Pigment Cell Res 18:227-33. 2005..These findings support previous hypotheses that GPCR-mediated signaling might also operate at the internal membranes in mammalian cells...
- Ceramide-induced apoptosis: role of catalase and hepatocyte growth factorRam Kannan
The Arnold and Mabel Beckman Macular Research Center, Keck School of Medicine of the University of Southern California, Los Angeles 90033, USA
Free Radic Biol Med 37:166-75. 2004..The ability of HGF to attenuate these effects demonstrates its effectiveness as an antioxidant growth factor...
- Polarity and developmental regulation of two PDZ proteins in the retinal pigment epitheliumV L Bonilha
Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Invest Ophthalmol Vis Sci 42:3274-82. 2001..Identification of binding partners for ezrin, an actin-binding protein crucial for morphogenesis of apical microvilli and basolateral infoldings in RPE cells...
- Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in miceShizuya Saika
Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
Lab Invest 84:1245-58. 2004..The results suggest that blocking the Smad3 pathway might be beneficial in prevention/treatment of PVR...
- Oxidative damage and age-related macular degenerationB S Winkler
Eye Research Institute, Oakland University, Rochester, MI 48309, USA
Mol Vis 5:32. 1999....
- Acute retinal pigment epithelial tear following intravitreal bevacizumab (Avastin) injection for occult choroidal neovascularisation secondary to age related macular degenerationC H Meyer
Br J Ophthalmol 90:1207-8. 2006
- Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cellsShizuya Saika
Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama 641 0012, Japan
Lab Invest 85:838-50. 2005..Gene transfer of DN-p38MAPK attenuated the post-retinal detachment fibrotic reaction of the retinal pigment epithelium in vivo in mice, supporting its effectiveness in preventing/treating PVR...
- Adeno-associated virus-vectored gene therapy for retinal diseaseAstra Dinculescu
Department of Ophthalmology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
Hum Gene Ther 16:649-63. 2005..Because of the key role of the vasculature in maintaining a healthy retina, a summary of AAV gene therapy applications in animal models of retinal neovascular diseases is also included...
- Cotransport of H+, lactate, and H2O in porcine retinal pigment epithelial cellsSteffen Hamann
Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
Exp Eye Res 76:493-504. 2003....
- Taurine uptake by human retinal pigment epithelium: implications for the transport of small solutes between the choroid and the outer retinaJost Hillenkamp
Department of Ophthalmology, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Invest Ophthalmol Vis Sci 45:4529-34. 2004..To identify the rate limiting compartment in the pathway of taurine delivery from the choroidal blood supply to the outer retina composed by Bruch's-choroid (BC) and the RPE in the human older age group...
- Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakageAniruddha C Amrite
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha 68198 5840, USA
Invest Ophthalmol Vis Sci 47:1149-60. 2006....
- Current understanding on the role of retinal pigment epithelium and its pigmentationU Schraermeyer
Department of Vitreoretinal Surgery, University of Cologne, Germany
Pigment Cell Res 12:219-36. 1999..Most of these functions are not yet understood. Deficit of melanin pigment is associated with age-related macula degeneration, the leading cause of blindness...
- Retinal pigment epithelium of the rat express CD81, the target of the anti-proliferative antibody (TAPA)Eldon E Geisert
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Invest Ophthalmol Vis Sci 43:274-80. 2002..The present study focuses on the role of CD81, the target of the anti-proliferative antibody (TAPA), in the regulation of the growth of retinal pigment epithelium (RPE)...
- Identification of novel bovine RPE and retinal genes by subtractive hybridizationShiwani Sharma
Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia
Mol Vis 8:251-8. 2002..With this aim, we undertook a systematic effort to identify and begin characterization of such genes...
- Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrierJulia V Busik
Department of Physiology, Michigan State University, 3155 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA
Invest Ophthalmol Vis Sci 43:2356-63. 2002....
- Persistent subretinal indocyanine green induces retinal pigment epithelium atrophyAkira Hirata
Department of Ophthalmology, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
Am J Ophthalmol 136:353-5. 2003..To describe a case of a patient with macular hole with subretinal indocyanine green (ICG) during vitrectomy...
- Stimulation of L-type Ca(2+) channels by increase of intracellular InsP3 in rat retinal pigment epithelial cellsStefan Mergler
Universitätsklinikum Charité der Humboldt Universität zu Berlin, Medizinische Klinik, Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany
Exp Eye Res 74:29-40. 2002..This is enabled by depletion of cytosolic Ca(2+)stores and tyrosine kinase-dependent activation of L-type channels...
- SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degenerationEmiko Kasahara
Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
Invest Ophthalmol Vis Sci 46:3426-34. 2005....
- Suppression of cAMP-induced pigment granule aggregation in RPE by organic anion transport inhibitorsD M Garcia
Department of Molecular and Cell Biology, University of California, Berkeley 94720
Invest Ophthalmol Vis Sci 35:178-88. 1994..To investigate the mechanism(s) by which intracellular cAMP levels are elevated to induce pigment granule aggregation in teleost retinal pigment epithelium (RPE)...
- NEUTROPHINS AND RETINAL DEVELOPMENTJanet Sparrow; Fiscal Year: 2001..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
- SUBMACULAR SURGERY TRIALS PATHOLOGY CENTERHans Grossniklaus; Fiscal Year: 2003..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
- Control of Eye Melanoma MetastsisHans E Grossniklaus; Fiscal Year: 2010..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
- Control of Eye Melanoma MetastasisHans Grossniklaus; Fiscal Year: 2003..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
- Determinants of Phenotype in Retinal Pigment EpitheliumJanice Burke; Fiscal Year: 2007..To determine whether the anticipated loss of polarity in RPE cells leads to a clinically or morphologically detectable retinal degeneration. ..
- BIOLOGICAL PROPERTIES OF RPE MELANINJanice M Burke; Fiscal Year: 2010..The effects of age on melanosomes will also be studied to determine whether their ability to protect RPE cells from stress declines over time, which could contribute to diseases of the retina such as age-related macular degeneration. ..
- PATHOGENESIS OF RETINAL DEGENERATIONSSamuel Jacobson; Fiscal Year: 2001..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
- Early-onset retinal degenerationsSamuel Jacobson; Fiscal Year: 2005....
- Gas6/Mertk mediated phagocytosis of OS by RPE cellsMichael Hall; Fiscal Year: 2005..abstract_text> ..
- NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSISMartin Katz; Fiscal Year: 2003....
- TRANSMISSION ELECTRON MICROSCOPEMartin Katz; Fiscal Year: 2006..Broadening the user base will help make the cost per user of maintaining the instrument as low as possible. [unreadable] [unreadable]..
- Alpha v beta 5 integrin in retinal pigment epitheliumSILVIA FINNEMANN; Fiscal Year: 2004..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
- The Integrin Ligand MFG-E8 and Photoreceptor Outer Segment Renewal.SILVIA FINNEMANN; Fiscal Year: 2007....
- Phospholipid and Arachidonic Acid Signaling in EpilepsyNicolas Bazan; Fiscal Year: 2007..abstract_text> ..
- METABOLIC AND HOMEOSTATIC MECHANISMS IN RETINA AND RPEBarry Winkler; Fiscal Year: 2003..g., diamox) which have been reported to decrease retinal edema. A long-term goal of the second project is to understand better the nature of the interactions between the retina and RPE and factors regulating retinal detachment. ..
- Photoreceptor Cell Vulnerability and Glutathione StatusBarry S Winkler; Fiscal Year: 2010..These outcomes should help in the design of therapeutic treatments for photoreceptor degenerations that are linked to an inadequate antioxidative defense mechanism. ..
- NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCINFrancois DeLori; Fiscal Year: 2005..The proposed studies will provide needed data on relationships among AMD, lipofuscin and macular pigment, estimate genetic contribution to the latter, and assist identification of individuals at greatest risk for vision loss. ..
- Subconjunctival Route to Prolong Corticosteroid DeliveryUday Kompella; Fiscal Year: 2005..Based on this study, the PI will submit an RO-l proposal to assess subconjunctival budesonide-PLGA particles for the therapy of posterior segment disorders associated with inflammation and/or VEGF elevation. ..
- Multi-Ethnic Study of Atherosclerosis-Eye StudyRonald Klein; Fiscal Year: 2005..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
- PROTEOMIC ANALYSIS OF AGE-RELATED MACULAR DEGENERATIONTONGALP TEZEL; Fiscal Year: 2007..unreadable] [unreadable]..
- Local Retinal Antigen PresentationDALE SANNES GREGERSON; Fiscal Year: 2010..dendritic cells;or 2. MHC class II on subsets of immune cells in the retina. The ability of circulating antigen presenting cells, or their precursors, to replace these deficiencies in antigen presentation will be tested. ..
- Proteasome function in the aging retinaDeborah A Ferrington; Fiscal Year: 2010..Results from these experiments will help verify that immunoproteasome is an essential component of the retinal stress response and plays a fundamental role in maintaining retinal health. ..
- Novel Risk Factors for Chronic Kidney DiseaseRonald Klein; Fiscal Year: 2008..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
- SMOKING-RELATED OXIDANTS,HTN, & DRY MACULAR DEGENERATIONMARIA MARIN CASTANO; Fiscal Year: 2008..unreadable] [unreadable]..
- Proteomics of altered protein in macular degenerationDEBORAH FERRINGTON; Fiscal Year: 2006..Identification of proteins that are uniquely altered will help provide valuable insight into the mechanism of AMD. ..
- Fluid Movement across Conjunctiva: Stimulation and RegulationOSCAR CANDIA; Fiscal Year: 2007..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
- Age-related epigenetic gene silencing in the RPELEONARD HJELMELAND; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ECM Regulation by Estrogen in ARMDSharon Elliot; Fiscal Year: 2006..Conversely, we expect that estrogen's antioxidant action on the cell membrane will diminish MPO-induced blebbing and that activation of estrogen receptors will modify matrix molecule dysregulation. ..
- Measurement of Fluid Flow Across the Ocular Ciliary BodyOSCAR CANDIA; Fiscal Year: 2006..abstract_text> ..
- RPE65 IN RETINAL METABOLISM AND DEGENERATIONDebra Thompson; Fiscal Year: 2005..The long-term goals of this project are to elucidate the mechanisms by which RPE65 defects contribute to retinal degeneration, and to lay the groundwork for the development of therapeutic approaches to the disease. ..
- EPIGENETIC AGING OF THE OXIDATIVE STRESS RESPONSE IN THE MOUSE RPEZeljka Smit McBride; Fiscal Year: 2010..This work will eventually lead to the development of individualized treatments for blinding eye diseases. ..
- Microvascular - Macrovascular Disease in Type 2 DiabetesRonald Klein; Fiscal Year: 2005....
- RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITYRonald Klein; Fiscal Year: 2002..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
- SIGNIFICANCE OF IMMUNOLOGICAL SEQUESTRATION IN THE EYEDALE SANNES GREGERSON; Fiscal Year: 2010..Aim II examines the possibility that local antigen presenting cells are limiting, in number and/or function, thus contributing to retinal immune ignorance and privilege. ..
- GENERATION OF MODELS FOR GENETIC HEARING LOSSDANA ORTEN; Fiscal Year: 2003..Understanding disease processes will be the basis for designing and testing new treatments that could reduce or prevent human inherited hearing loss. ..
- CORNEAL ENDOTHELIAL CELL IMMUNOREGULATORY FACTORSDALE GREGERSON; Fiscal Year: 2003..identify the activity(s) to learn if it is a known factor(s); and 3. if the activity has not already been described, continue characterization of the factor(s) and mechanism of action. ..
- Retinal Microvascular Characteristics/Vascular DisordersRonald Klein; Fiscal Year: 2003..abstract_text> ..
- SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVAOSCAR CANDIA; Fiscal Year: 2002..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
- Retinal Circadian Signaling in a Transgenic ModelAllan Wiechmann; Fiscal Year: 2004..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
- REDOX CONTROL OF FGF GENE EXPRESSION IN AGING RPELEONARD HJELMELAND; Fiscal Year: 2002..Our hypothesis provides a plausible link between cell death in the outer retina and the events of oxidative stress and RPE aging and may provide new approaches for the understanding and treatment of AMD. ..
- WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEASRonald Klein; Fiscal Year: 2002....
- S100B Transgenic Mice and AMDKimberly Howes; Fiscal Year: 2004..abstract_text> ..
- Central Scotomas in AMD and Cortical RemappingJanet Sunness; Fiscal Year: 2005....
- GLUTAMINE AND BREAST CANCER PROLIFERATION AND TREATMENTSTEVE ABCOUWER; Fiscal Year: 2002..This may provide the basis for novel metabolically directed cancer therapies. ..
- Caloric Restriction and Aging in EyesPeter Gouras; Fiscal Year: 2010..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..
- SMCT1 & SMCT2: expression in retina & relevance to diabetic retinopathyPamela Martin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Cellular and Molecular Mechanisms Regulating Photoreceptor MorphologyABIGAIL JENSEN; Fiscal Year: 2008..This raises the interesting question as to whether this phenomenon is causal or whether compromised or sick photoreceptors are unable to maintain their inner and outer segments. ..
- CHLORIDE TRANSPORT IN HUMAN CILIARY EPITHELIUMRichard Crook; Fiscal Year: 2001..He also proposes to test the hypothesis that other hormones known to either increase or decrease aqueous inflow might exert their effects through modulation of Na+, K+, Cl cotransport activity. ..
- PHOTOCHEMISTRY OF HUMAN RETINAL LIPOFUSCINELIZABETH GAILLARD; Fiscal Year: 2002..Information from these studies may allow for the development of protocols to slow down or stop the processes that lead to irreversible damage to the human retina ..
- EYE GROWTH DURING INFANCYScott Lambert; Fiscal Year: 2001..In addition, by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth which occurs in certain pathological conditions such as retinopathy of prematurity. ..
- Prevention of Photoreceptor DegenerationRaymond Lund; Fiscal Year: 2005..abstract_text> ..
- Actin and myosins in organelle motilityChristina King Smith; Fiscal Year: 2003..The proposed research will contribute to a better understanding of actin-dependent organelle motility, a universal characteristic of eukaryotic cells. ..
- Genetic model of retinal pigment epithelium degenerationDouglas Vollrath; Fiscal Year: 2005....
- Expression and Regulation of Retinal Angiotensin IIPreenie Senanayake; Fiscal Year: 2005..Ultimately retinal Ang receptors could be specifically targeted with selective therapeutic agents to prevent the development of proliferative diabetic retinopathy. ..
- COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDYRobert Ritch; Fiscal Year: 2003....
- Dyslipidemia and retinal endothelial cell dysfunctionJulia Busik; Fiscal Year: 2004..The outcome of this work will lead to a better understanding of how diabetic dyslipidemia contributes to altered hRVE cell phenotype and the onset and progression of diabetic retinopathy. ..
- Genoplasty in Ocular Gene TherapyJOHN NICKERSON; Fiscal Year: 2004..abstract_text> ..
- CHARACTERIZATION OF GENES IN NORMAL AND AMD RETINASCatherine Bowes Rickman; Fiscal Year: 2005..Understanding normal foveal cone biology and its alteration in disease will provide the rationale for therapies to prolong photoreceptor survival in macular degeneration. ..
- ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONSJanee Gelineau van Waes; Fiscal Year: 2003..abstract_text> ..
- Murine Age-related Macular Degeneration: Model of Known Human Risk FactorsCatherine Bowes Rickman; Fiscal Year: 2007..Analysis of these animals will provide insight into the pathogenesis of AMD as well as a means to separate the relative contribution and degenerative effects of specific risk factors. [unreadable] [unreadable] [unreadable]..
- p27Kip1 and RPE Cell CycleDENNIS DEFOE; Fiscal Year: 2003..The alternative hypothesis that the thickening of the RPE layer is due to an increase in cell size will be examined by morphometric analysis of images obtained by confocal microscopy. ..
- p27(Kip1) and Retinal AttachmentDENNIS DEFOE; Fiscal Year: 2008..To test this, the Cre-lox system for conditional gene targeting will be implemented to ablate the p27(Kip1) gene selectively in RPE cells. [unreadable] [unreadable] [unreadable]..
- Culture and Transplantation of Human Retinal SpheresDAVID GAMM; Fiscal Year: 2008..Together, these experiments are designed to build on recent advances in the burgeoning field of stem cell biology and apply them to the basic and clinical science of ophthalmology. ..