eyelids

Summary

Top Publications

  1. ncbi Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids
    M A Stepp
    Department of Anatomy and Cell Biology, Department of Ophthalmology, The George Washington University Medical Center, Washington, DC 20037, USA
    Dev Dyn 214:216-28. 1999
  2. ncbi A survey of trachoma: the histopathology and the mechanism of progressive cicatrization of eyelid tissues
    M Guzey
    Department of Ophthalmology, Harran University School of Medicine, Sanliurfa, Turkey
    Ophthalmologica 214:277-84. 2000
  3. ncbi Basal cell carcinoma on the eyelids: own experience
    Joanna Salomon
    Department of Dermatology and Venereology, University of Medicine, Wrocław, Poland
    Dermatol Surg 30:257-63. 2004
  4. pmc A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
    Lin Zhang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    EMBO J 22:4443-54. 2003
  5. pmc ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    Yoshihiko Shimizu
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 168:941-53. 2005
  6. ncbi Grhl3 and Lmo4 play coordinate roles in epidermal migration
    Nikki R Hislop
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, c o Royal Melbourne Hospital Post Office, Parkville, VIC 3050, Australia
    Dev Biol 321:263-72. 2008
  7. ncbi Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology
    S E Clements
    St John s Institute of Dermatology, King s College London Guy s Campus, London SE1 9RT, UK
    Br J Dermatol 167:134-44. 2012
  8. ncbi Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation
    E De Baere
    Department of Medical Genetics, Ghent University Hospital, B 9000 Ghent, Belgium
    Hum Mol Genet 10:1591-600. 2001
  9. ncbi ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo
    Dean Thumkeo
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 10:825-34. 2005
  10. ncbi HB-EGF promotes epithelial cell migration in eyelid development
    Naoki Mine
    Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 132:4317-26. 2005

Detail Information

Publications301 found, 100 shown here

  1. ncbi Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids
    M A Stepp
    Department of Anatomy and Cell Biology, Department of Ophthalmology, The George Washington University Medical Center, Washington, DC 20037, USA
    Dev Dyn 214:216-28. 1999
    As previously reported, alpha9 integrin is expressed between the merged or fused eyelids of mice at birth, and changes in alpha9 localization occur during lid opening...
  2. ncbi A survey of trachoma: the histopathology and the mechanism of progressive cicatrization of eyelid tissues
    M Guzey
    Department of Ophthalmology, Harran University School of Medicine, Sanliurfa, Turkey
    Ophthalmologica 214:277-84. 2000
    ..Specimens of eyelid tissues were taken from 27 upper eyelids of 21 patients with entropion who underwent surgical procedures and 2 post-mortem upper eyelids with severe ..
  3. ncbi Basal cell carcinoma on the eyelids: own experience
    Joanna Salomon
    Department of Dermatology and Venereology, University of Medicine, Wrocław, Poland
    Dermatol Surg 30:257-63. 2004
    Basal cell carcinoma (BCC) is the most common skin malignancy. Eyelids constitute a special location of BCC because of the proximity of the eyeball.
  4. pmc A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
    Lin Zhang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    EMBO J 22:4443-54. 2003
    ..This study also suggests that the signaling mechanisms that control eyelid closure in mammals and dorsal closure in Drosophila are evolutionarily conserved...
  5. pmc ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    Yoshihiko Shimizu
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 168:941-53. 2005
    ..These results suggest that ROCK-I regulates closure of the eyelids and ventral body wall through organization of actomyosin bundles.
  6. ncbi Grhl3 and Lmo4 play coordinate roles in epidermal migration
    Nikki R Hislop
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, c o Royal Melbourne Hospital Post Office, Parkville, VIC 3050, Australia
    Dev Biol 321:263-72. 2008
    ..Accumulation of actin fibers is also absent in the circumference of these eyelids, and ERK1/2 phosphorylation is lost in the epidermis and eyelids of Grhl3(-/-)/Lmo4(-/-) embryos...
  7. ncbi Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology
    S E Clements
    St John s Institute of Dermatology, King s College London Guy s Campus, London SE1 9RT, UK
    Br J Dermatol 167:134-44. 2012
    ..Clinically, the skin is dry and often fragile; other features can include partial eyelid fusion (ankyloblepharon), hypodontia, orofacial clefting, sparse hair or alopecia, and nail dystrophy...
  8. ncbi Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation
    E De Baere
    Department of Medical Genetics, Ghent University Hospital, B 9000 Ghent, Belgium
    Hum Mol Genet 10:1591-600. 2001
    ..Furthermore, we propose that in a fraction of the BPES patients the genetic defect does not reside within the coding region of the FOXL2 gene and may be caused by a position effect...
  9. ncbi ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo
    Dean Thumkeo
    Department of Pharmacology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 10:825-34. 2005
    ..Consistently, ROCK-I(+/-)ROCK-II(+/-) double heterozygous mice also show the EOB and omphalocele phenotype...
  10. ncbi HB-EGF promotes epithelial cell migration in eyelid development
    Naoki Mine
    Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 132:4317-26. 2005
    ..In addition, activation of EGFR and ERK was decreased in HB(del/del) eyelids. Crosses between HB(del/del) mice and waved 2 mice, a hypomorphic EGFR mutant strain, indicate that HB-EGF and ..
  11. ncbi The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
    L Crisponi
    Istituto di Ricerca sulle Talassemie ed Anemie Mediterranee CNR, and Dipartimento di Scienze Biomediche e Biotecnologie, Ospedale Regionale per le Microcitemie, Universita degli Studi di Cagliari, Cagliari, Italy
    Nat Genet 27:159-66. 2001
    ..with an involvement in those tissues, FOXL2 is selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles; in adult humans, it appears predominantly in the ovary...
  12. ncbi c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
    Rainer Zenz
    Research Institute of Molecular Pathology IMP, A 1030, Vienna, Austria
    Dev Cell 4:879-89. 2003
    ..lacking c-jun in keratinocytes (c-jun(Deltaep)) develop normal skin but express reduced levels of EGFR in the eyelids, leading to open eyes at birth, as observed in EGFR null mice...
  13. pmc Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells
    Doreswamy Kenchegowda
    Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Dev Biol 356:5-18. 2011
    ..Klf5 mRNA was detected as early as embryonic day 12 (E12) in the cornea, conjunctiva and eyelids, wherein its expression increased during development...
  14. ncbi Severe skin erosions and scalp infections in AEC syndrome
    S L Vanderhooft
    Department of Medicine (Dermatology, University of Washington School of Medicine, Seattle 98195
    Pediatr Dermatol 10:334-40. 1993
    ..Aggressive wound care in conjunction with early administration of topical or systemic antibiotics is suggested...
  15. ncbi Lid swelling and diplopia as presenting features of orbital sarcoid
    J Biswas
    Medical Research Foundation, 18 College Road, Chennai 600 006, India
    Indian J Ophthalmol 48:231-3. 2000
    ..In the eye, the common sites of involvement are the skin of eyelid, conjunctiva, uveal tract, retina, optic nerve and lacrimal gland...
  16. ncbi Mucocutaneous junction of eyelid and lip: a study of the transition zone using epithelial cell markers
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Curr Eye Res 33:912-22. 2008
    ..The expression of epithelial cell markers in the mouse eyelid and lip was investigated in order to understand the nature of the interactions of mucosal and skin epithelium as to how they form the mucocutaneous junction (MCJ)...
  17. ncbi Mutations in FOXL2 underlying BPES (types 1 and 2) in Colombian families
    J L Ramirez-Castro
    Unidad de Genética Médica, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
    Am J Med Genet 113:47-51. 2002
    ....
  18. ncbi The trachomatous trichiasis clamp: a surgical instrument designed to improve bilamellar tarsal rotation procedure outcomes
    Shannath L Merbs
    Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arch Ophthalmol 130:220-3. 2012
    ....
  19. ncbi Organization of trigeminocollicular connections and their relations to the sensory innervation of the eyelids in the rat
    Awa Ndiaye
    Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, 75251 Paris, France
    J Comp Neurol 448:373-87. 2002
    ..This implies that intermediate and deeper SC layers receive sensory information from the eyelids and may be directly involved in the regulation of eye-eyelid coordination.
  20. ncbi Primary herpes simplex virus type 1 infection of the eye triggers similar immune responses in the cornea and the skin of the eyelids
    Thomas H Stumpf
    Division of Ophthalmology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Gen Virol 83:1579-90. 2002
    ..The eyes and eyelids of infected and control mice were processed for immunohistochemistry and double stained for viral antigens and ..
  21. ncbi Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice
    Hyun Mi Kang
    Department of Biotechnology, Seoul Women s University, Seoul, Korea
    Stem Cells 27:1999-2008. 2009
    ..In conclusion, human insulin alone produced from eyelid-derived stem cells following differentiation into insulin-secreting cells and transplantation could normalize type I diabetes in mice...
  22. ncbi c-Jun is essential for organization of the epidermal leading edge
    Guochun Li
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 4:865-77. 2003
    ..Lack of c-Jun prevents EGF-induced expression of HB-EGF, indicating that c-jun controls formation of the epidermal leading edge through its control of an EGF receptor autocrine loop...
  23. ncbi Characteristic ocular findings in Asian children with Down syndrome
    J H Kim
    Department of Ophthalmology, College of Medicine, Seoul National University and Clinical Research Institute Seoul National University Hospital, Seoul, Korea
    Eye (Lond) 16:710-4. 2002
    ..AIMS/PURPOSE: To identify the characteristic ocular findings in Asian children with Down syndrome...
  24. pmc Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis
    VERONICA G BEAUDRY
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305 5152, USA
    Am J Med Genet A 149:1952-7. 2009
    ..Elucidating how specific TP63 target genes contribute to the pathogenesis of AEC will ultimately help design novel approaches to diagnose and treat AEC...
  25. pmc DeltaNp63 knockdown mice: A mouse model for AEC syndrome
    Maranke I Koster
    Department of Dermatology and Charles C Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Med Genet A 149:1942-7. 2009
    ..c) 2009 Wiley-Liss, Inc...
  26. ncbi What causes eyelid bags? Analysis of 114 consecutive patients
    Robert Alan Goldberg
    Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 7006, USA
    Plast Reconstr Surg 115:1395-402; discussion 1403-4. 2005
    ..The purpose of this study was to identify the anatomical basis for perception of lower eyelid bags in patients seeking aesthetic surgery and to evaluate the cumulative contribution of different anatomic characteristics before surgery...
  27. ncbi Dermatologic findings of ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome
    Meena R Julapalli
    Texas Children s Hospital, Department of Pediatric Dermatology, Baylor College of Medicine, 6621 Fannin Street, Houston, TX 77030, USA
    Am J Med Genet A 149:1900-6. 2009
    ..Therapeutic strategies currently under exploration include gene therapy, as well as epidermal stem cell therapy. Until then, gentle wound care and limiting further trauma seem to be the most prudent treatment modalities...
  28. ncbi In vivo confocal microscopy of the ocular surface
    Andrey Zhivov
    Department of Ophthalmology, University of Rostock, Rostock, Germany
    Ocul Surf 4:81-93. 2006
    ..The purpose of this review is to summarize the current knowledge about in vivo confocal microscopy of the ocular surface...
  29. ncbi Bacterial flora--A potential source of endophthalmitis after cataract surgery
    Yong Rongrungruang
    Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
    J Med Assoc Thai 88:S49-53. 2005
    ..To study bacteria from eye lids and conjunctival sac of patients undergoing cataract surgery before and after the application of antiseptics...
  30. ncbi Lymphatic vessels in human eyelids: an immunohistological study in dermatochalasis and chalazion
    M Agliano
    Department of Biomedical Sciences, Anatomy and Histology Section, University of Siena, Italy
    Lymphology 41:29-39. 2008
    We investigated lymphatic morphology and expression of endothelin (ET-1) axis molecules in human eyelids affected by an inflammatory state (chalazion) and an age-related degenerative condition (dermatochalasis)...
  31. pmc Ankyloblepharon filiforme adnatum
    M A Williams
    Eye and Ear Clinic, Royal Victoria Hospital, Belfast, UK
    Arch Dis Child 92:73-4. 2007
    ..Two cases of a rare congenital eyelid abnormality, ankyloblepharon filiforme adnatum, are presented, and novel aspects of treatment, associations and classification are discussed...
  32. ncbi [Plastic reconstructive correction of persistent orofacial swelling and swelling of the eyelids in Melkersson-Rosenthal syndrome]
    Focke Ziemssen
    Universitätsaugenklinik Tübingen, Abt 1
    Klin Monbl Augenheilkd 220:352-6. 2003
    ..The Melkersson-Rosenthal syndrome complex is characterised by asymmetric orofacial oedema, facial palsy, furrowed tongue (lingua plicata) and additional neurological symptoms...
  33. ncbi Anterior lamellar repositioning with complete lid split: a modified method for treating upper eyelids trichiasis in Asian patients
    Y L Bi
    Division of Ophthalmic Plastic Surgery, Department of Ophthalmology, Tongji Hospital, Affiliate of Tongji University, 389, Xin Cun Road, Shanghai 200065, People s Republic of China
    J Plast Reconstr Aesthet Surg 62:1395-402. 2009
    Anatomically, the upper eyelids of an Asian are considerably unique, and nearly half of the East Asians have single eyelids...
  34. ncbi Congenital eyelid imbrication syndrome
    D J De Silva
    Eye (Lond) 20:1103-4. 2006
  35. ncbi Management of canalicular lacerations: epidemiological aspects and experience with Mini-Monoka monocanalicular stent
    Milind N Naik
    Division of Ophthalmic Plastic Surgery, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad, India
    Am J Ophthalmol 145:375-380. 2008
    ..To report the epidemiological data, clinical profile, and surgical outcome of canalicular lacerations in an Indian population...
  36. ncbi Three novel FOXL2 gene mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome
    Siu fong June Or
    Clinical Genetic Service, Department of Health, Hong Kong SAR, China
    Chin Med J (Engl) 119:49-52. 2006
  37. ncbi Pathologic changes of skin and hair in ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome
    Megan K Dishop
    Department of Pathology, Texas Children s Hospital, Baylor College of Medicine, 6621 Fannin, Houston, TX 77030, USA
    Am J Med Genet A 149:1935-41. 2009
    ..Skin and hair findings in AEC syndrome were found to be generally similar to those described in other ectodermal dysplasia syndromes and corroborates the few prior descriptions in AEC syndrome specifically...
  38. ncbi Full-thickness lower eyelid reconstruction with a conchal chondro-perichondral graft and local coverage with Mio-cutaneous flaps--our divisional experience
    Pier Camillo Parodi
    Department of Plastic, Reconstructive and Aesthetic Surgery, University of Udine, Udine, Italy
    J Oral Maxillofac Surg 66:1826-32. 2008
    ....
  39. ncbi Oral findings in ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome
    Frank Farrington
    Virginia Commonwealth University School of Dentistry, Pediatric Dentistry, 521 North 11th Street, Richmond, VA 23298, USA
    Am J Med Genet A 149:1907-9. 2009
    ..History indicated that issues related to treatment of the palatal cleft and lack of recognition of the oral defects as a part of the underlying medical problem were factors in receiving comprehensive tooth replacement care...
  40. ncbi Antibiotic resistance patterns of ocular bacterial flora: a prospective study of patients undergoing anterior segment surgery
    Christopher N Ta
    Department of Ophthalmology, School of Medicine, Stanford University, 900 Blake Wilbur Drive, Stanford, CA 94304, USA
    Ophthalmology 110:1946-51. 2003
    ..To determine the antibiotic susceptibility patterns of conjunctival bacterial flora isolated preoperatively from patients undergoing anterior segment surgery...
  41. ncbi Congenital eyelid imbrication syndrome
    Shimon Rumelt
    Department of Ophthalmology, Western Galilee Nahariya Medical Center, PO Box 21, 22100 Nahariya, Israel
    Am J Ophthalmol 138:499-501. 2004
    ..To describe congenital eyelid imbrication syndrome and its possible pathophysiology...
  42. ncbi Recurrence of trichiasis: a long-term follow-up study in the Sultanate of Oman
    R Khandekar
    Ministry of Health, Muscat, Sultanate of Oman
    Ophthalmic Epidemiol 8:155-61. 2001
    ..DISCUSSION: The risk of recurrence after electro-epilation and bilamellar tarsal rotation surgery is high; strategies that account for recurrence need to be introduced...
  43. ncbi Turnover and migration of meibomian gland cells in rats' eyelids
    Y Olami
    Department of Ophthalmology, Hadassah University Hospital and Hebrew University-Hadassah Faculty of Medicine, Jerusalem, Israel
    Ophthalmic Res 33:170-5. 2001
    ..The eyes and eyelids were removed in one piece, fixed in formalin, embedded in paraffin and cut into 5-micron-thick vertical sections ..
  44. ncbi Recovery of orbital fat pad prolapsus and deepening of the lid sulcus from topical bimatoprost therapy: 2 case reports and review of the literature
    Sayime Aydin
    Ophthalmology Department, Dumlupinar University School of Medicine, Kutahya, Turkey
    Cutan Ocul Toxicol 29:212-6. 2010
    ..To report 2 cases of resolution of orbital fat pad prolapsus and deepening of the lid sulcus caused by topical bimatoprost therapy, and to review the literature...
  45. ncbi Canalicular lacerations: repair with the Mini-Monoka® monocanalicular intubation stent
    Igal Leibovitch
    Oculoplastic and Orbital Division, Department of Ophthalmology, Tel Aviv Sourasky Medical Center, 6 Weitzman Street, Tel Aviv, 64239, Israel
    Ophthalmic Surg Lasers Imaging 41:472-7. 2010
    ..There are different techniques for reconstructing traumatic canalicular lacerations. The aim of this study is to report the surgical outcome with the Mini-Monoka monocanalicular stent (FCI Ophthalmics, Issy-Les Moulineaux, France)...
  46. ncbi Differential effects of reflex blinks on saccade perturbations in humans
    H H L M Goossens
    Donders Inst for Brain, Cognition and Behaviour, Dept of Biophysics, Radboud Univ Nijmegen Medical Ctr, G Grooteplein 21, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Neurophysiol 103:1685-95. 2010
    ..These findings support the theory that blink-perturbed saccades are programmed as slow, but straight, saccades onto which blink-related eye movements are superimposed. This linear superposition occurs downstream from the SC...
  47. ncbi Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias
    Gareth Browne
    Medical Research Council, Leicester University, Leicester LE19HN, UK
    J Cell Sci 124:2200-7. 2011
    ..Disruption of this regulatory mechanism might contribute to the pathology of p63-related developmental disorders...
  48. ncbi Eyelid avulsion repair with bi-canalicular silicone stenting without medial canthal tendon reconstruction
    Naing L Tint
    Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK
    Br J Ophthalmol 95:1389-92. 2011
    ....
  49. doi Ankyloblepharon filiforme adnatum
    Don Sharkey
    Academic Division of Child Health, University of Nottingham, United Kingdom
    J Pediatr 152:594. 2008
  50. ncbi Open loop fascial sling for severe congenital blepharoptosis
    Zakaria Yahya Arajy
    Scientific Council of Plastic Surgery, Iraqi Board for Medical Specializations, Baghdad, Iraq
    J Craniomaxillofac Surg 40:129-33. 2012
    ..We describe a simple open loop fascia lata suspension sling to the frontalis muscle to treat patients with severe eyelid ptosis and poor levator function...
  51. ncbi 'Kite-tail' fascia lata strips technique: frontalis suspension using a non-endoscopic minimally invasive single-thigh incision approach
    Cem Evereklioglu
    Department of Ophthalmology, Division of Oculoplastic, Orbital and Lacrimal Surgery, Erciyes University Medical Faculty, Kayseri, Turkey
    Br J Ophthalmol 96:570-5. 2012
    ..To introduce 'kite-tail' strips or a 'multiple Z-plasty' technique on an autogenous fascia lata graft without a stripper to correct severe blepharoptosis by frontalis suspension and to evaluate its effectiveness on surgical outcome...
  52. ncbi Blepharoptosis repaired by frontalis-orbicularis oculi flap: a new technique
    Keerapat Bhiromekraibhak
    Plastic and Reconstructive Division, Department of Surgery, Faculty of Medicine, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, Thailand
    J Med Assoc Thai 93:S15-20. 2010
    ..Recently the orbicularis oculi flap has become popular but lagopthalmos is still a bothersome problem. A new technique has been introduced in order to reduce the lagopthalmos...
  53. pmc Macaque pontine omnipause neurons play no direct role in the generation of eye blinks
    K P Schultz
    Department of Vision Sciences and Vision Science Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neurophysiol 103:2255-74. 2010
    ..In addition, the OPN pause continued for 40-60 ms after the time of the maximum downward closing of the eyelids, which occurs around the end of the OOMN burst of firing...
  54. ncbi Mini-invasive ptosis surgery
    Francesco P Bernardini
    Ospedale Evangelico Internazionale, Genova and Ospedale Evangelico Valdese, Torino, Italy
    Orbit 25:111-5. 2006
    ..We believe that, in a selected group of patients, a less invasive approach with an upper lid skin incision of only 0.8 cm is equally effective for the final result and offers several advantages compared to the traditional technique...
  55. ncbi A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development
    Hirotaka Tao
    Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, 2 1 Minami Jyosanjima, Tokushima 770 8506, Japan
    Development 132:3217-30. 2005
    ..Mutant mice deficient in the fibroblast growth factor 10 (Fgf10) gene exhibit open-eyelids at birth...
  56. ncbi Double-eyelid blepharoplasty incorporating blepharoptosis surgery for 'latent' aponeurotic ptosis
    Jin Li
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, PR China
    J Plast Reconstr Aesthet Surg 64:993-9. 2011
    ..as the failure to create double-eyelid skin creases and the outcome of higher skin creases and asymmetrical upper eyelids. These complications may happen even when the surgery proceeded successfully and the septum was intact, which ..
  57. ncbi Primary bilateral silicone frontalis suspension for good levator function ptosis in oculopharyngeal muscular dystrophy
    Richard C Allen
    Department of Surgery, Division of Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico USA
    Br J Ophthalmol 96:841-5. 2012
    ..To evaluate outcomes of patients with oculopharyngeal muscular dystrophy (OPMD) with levator function (LF) ≥ 10mm who underwent primary bilateral silicone frontalis suspension...
  58. ncbi Prediction of postoperative eyelid height after frontalis suspension using autogenous fascia lata for pediatric congenital ptosis
    Chang Yeom Kim
    The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    Am J Ophthalmol 153:334-342.e2. 2012
    ..To predict eyelid height after frontalis suspension using autogenous fascia lata for congenital ptosis...
  59. pmc Interactions between gaze-evoked blinks and gaze shifts in monkeys
    Neeraj J Gandhi
    Department of Otolaryngology, Center for Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA
    Exp Brain Res 216:321-39. 2012
    ....
  60. ncbi The distribution of primary afferent terminals from the eyelids of macaque monkeys
    P J May
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216, USA
    Exp Brain Res 123:368-81. 1998
    Trigeminal sensory afferents from the eyelids convey two types of information that are important for the blink reflex. Movement of the lashes activates low-threshold mechanoreceptors which evoke protective blinks...
  61. ncbi A novel mutation in the FOXL2 gene in a patient with blepharophimosis syndrome: differential role of the polyalanine tract in the development of the ovary and the eyelid
    Kenjiro Kosaki
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Ophthalmic Genet 23:43-7. 2002
    ..inversus syndrome (BPES) is an autosomal dominant disorder characterized by abnormalities of the eyelids. We herein report a 12-year-old girl with BPES who had bilateral blepharophimosis, ptosis, hypertelorism, and ..
  62. pmc Temporal interactions of air-puff-evoked blinks and saccadic eye movements: insights into motor preparation
    Neeraj J Gandhi
    Deptartment of Otolaryngology and Center for Neural Basis of Cognition, Eye and Ear Institute, University of Pittsburgh, RM 108, 203 Lothrop St, Pittsburgh, PA 15213, USA
    J Neurophysiol 93:1718-29. 2005
    ..Collectively, these results support the notion that temporal features of the low-frequency activity encode aspects of a premotor command and imply that inhibition of OPNs alone is not sufficient to trigger saccades...
  63. ncbi Double lacrimal puncta: clinical presentation and potential mechanisms of epiphora
    Khami Satchi
    Orbital Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Ophthalmology 117:180-183.e2. 2010
    ..Congenital supernumerary lacrimal puncta and canaliculi are rarely reported. Our purpose is to present the largest series of patients with supernumerary puncta and to describe the clinical presentation and associated lacrimal anomalies...
  64. ncbi One-stage correction for blepharophimosis syndrome
    S Y Wu
    Department of Ophthalmology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Kewi Shan, Taoyuan, Taiwan, Republic of China
    Eye (Lond) 22:380-8. 2008
    ..To classify the severity of blepharophimosis, describe associated features and their effects on the incidence of amblyopia and to recommend guidelines for surgical treatment and management of surgical complications...
  65. ncbi The relationship between demodex and ocular discomfort
    Seok Hyun Lee
    Department of Ophthalmology, College of Medicine, Chung Ang University, Yongsan Hospital, Seoul, Korea
    Invest Ophthalmol Vis Sci 51:2906-11. 2010
    ..To determine the correlative relationship between the prevalence of Demodex in eyelashes and the severity of ocular discomfort, by investigating the demographic epidemiology associated with Demodex...
  66. ncbi Skin erosions and wound healing in ankyloblepharon-ectodermal defect-cleft lip and/or palate
    Elaine Siegfried
    Kids Dermatology, 621 S New Ballas Road, St Louis, MO 63141, USA
    Arch Dermatol 141:1591-4. 2005
  67. ncbi Anesthesia with EMLA cream for botulinum A toxin injection into eyelids
    Meltem F Soylev
    School of Medicine, Dokuz Eylul University, TR 35320 Narlidere Izmir, Turkey
    Ophthalmologica 216:355-8. 2002
    ..of an eutectic mixture of local anesthetics (EMLA) in reducing the pain of a botulinum toxin injection into eyelids. 17 patients with facial dyskinesia (9 blepharospasm and 8 hemifacial spasm) who had been treated regularly with ..
  68. ncbi Conjunctival amyloidosis of both eyelids
    G Rodrigues
    Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India
    Indian J Ophthalmol 49:116-7. 2001
    ..We present our experience with this rare patient in whom both upper and lower palpebral conjunctivae were involved, but no systemic amyloidosis...
  69. ncbi Measuring and predicting eyelid spectral transmittance
    Andrew Bierman
    Rensselaer Polytechnic Institute, Lighting Research Center, 21 Union Street, Troy, New York 12180, USA
    J Biomed Opt 16:067011. 2011
    ..0. The study results indicate that skin pigmentation is poorly correlated with eyelid transmission; eyelid transmission is most affected by wavelength-independent macromolecules in the eyelid as well as its overall thickness...
  70. ncbi Magnetic resonance imaging characterization of orbital changes with age and associated contributions to lower eyelid prominence
    Sean J Darcy
    David Geffen School of Medicine, the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California, Los Angeles, USA
    Plast Reconstr Surg 122:921-9; discussion 930-1. 2008
    ..Multiple orbital aging models have been suggested to explain the progressive development of lower eyelid prominence. Objective data to support these theories are limited, however...
  71. ncbi Epibulbar nodular fasciitis associated with floppy eyelids
    Donald U Stone
    Molecular Pathogenesis of Eye Infection Research Center, Dean A McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cornea 24:361-2. 2005
    To report a case of epibulbar nodular fasciitis in a patient with floppy eyelids.
  72. ncbi Rapp-Hodgkin and Hay-Wells ectodermal dysplasia syndromes represent a variable spectrum of the same genetic disorder
    S E Clements
    St John s Institute of Dermatology, King s College London Guy s Campus, London SE1 9EH, U K
    Br J Dermatol 163:624-9. 2010
    ....
  73. ncbi [Surgical management of deep chemical burns of the eyelids]
    Agnieszka Zurada
    Z Katedry i Kliniki Chirurgii Plastycznej Akademii Medycznej w Bydgoszczy
    Klin Oczna 107:275-7. 2005
    Chemical burns of the eyelids are common, and this may lead to ocular damage. A direct insult of the eyes that result in permanent damage, is rare in facial burns...
  74. ncbi Eyelids and eye socket reconstruction using the expanded forehead flap and scapha composite grafting
    H Yanaga
    Department of Plastic and Reconstructive Surgery, Kurume University School of Medicine, 67, Asahi machi, Kurume, Fukuoka 830 0011, Japan
    Plast Reconstr Surg 108:8-16. 2001
    ..or excision of malignant tumor, it is difficult to achieve satisfactory results when reconstructing deformed eyelids and the socket for an ocular prosthesis...
  75. ncbi Update on minimally invasive face lift technique
    Antonio Fuente del Campo
    Private practice in Mexico City, Mexico, USA
    Aesthet Surg J 28:51-61; discussion 62. 2008
    ..Restorative procedures should be based on the condition of the soft tissues and the relationship between these tissues and the existing skeletal volume and can be performed through open, endoscopic, or minimally invasive approaches...
  76. pmc The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis
    Claire R Weston
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:14114-9. 2004
    ..We conclude that JNK is necessary for epithelial morphogenesis and is an essential regulator of signal transduction by the EGF receptor in the epidermis...
  77. pmc The clinical phenotype of trachomatous trichiasis in Ethiopia: not all trichiasis is due to entropion
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:7974-80. 2011
    ..This variation in clinical phenotype is potentially important for treatment guidelines. Therefore, this study was conducted to investigate the range of disease type and severity encompassed by TT...
  78. pmc A recurrent polyalanine expansion in the transcription factor FOXL2 induces extensive nuclear and cytoplasmic protein aggregation
    S Caburet
    INSERM E0021 Génomique fonctionnelle du Développement, Hopital Cochin, 123 Bd du Port Royal, Bâtiment Baudelocque, 75014 Paris, France
    J Med Genet 41:932-6. 2004
    ..This may diminish the pool of active protein. Potential effects of aggregation on cell viability are under study...
  79. pmc FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate
    Jie Huang
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63130, USA
    Development 136:1741-50. 2009
    ..Mice lacking Fgf10 or Fgfr2 also have open eyelids at birth...
  80. ncbi Frontalis muscle advancement: a dynamic structure for the treatment of severe congenital eyelid ptosis
    Oscar M Ramirez
    Johns Hopkins University and University of Maryland School of Medicine, Baltimore, MD, USA
    Plast Reconstr Surg 113:1841-9; discussion 1850-1. 2004
    ..Symmetry is created by intervention on the contralateral eyelid to provide symmetrical supratarsal creases...
  81. ncbi Congenital shortening of the anterior lamella of all eyelids: the so-called ablepharon macrostomia syndrome
    A A Cruz
    Department of Ophthalmology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Ophthal Plast Reconstr Surg 11:284-7. 1995
    ..abnormal ears, an enlarged, fishlike mouth, absence of lanugo, redundant skin, and vertical shortening of all eyelids. Only four cases have been described so far...
  82. pmc Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice
    Xin Du
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    Genetics 166:331-40. 2004
    ..5. Mice heterozygous for the Velvet mutation are born with eyelids open and demonstrate a wavy coat and curly vibrissae...
  83. ncbi Long-term results of frontalis suspension using autogenous fascia lata for congenital ptosis in children under 3 years of age
    Igal Leibovitch
    Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Ophthalmol 136:866-71. 2003
    ..To evaluate the outcome of frontalis suspension surgery for congenital ptosis using autogenous fascia lata for children under 3 years of age...
  84. ncbi A simplified technique of ptosis repair using a single adjustable suture
    M A Meltzer
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, USA
    Ophthalmology 108:1889-92. 2001
    ..The follow-up period ranged from 3 to 31 months. MAIN OUTCOME MEASURE: Lid position. RESULTS: All eyelids included in this study were corrected to 1 mm of the desired result...
  85. pmc Serum response factor is essential for the proper development of skin epithelium
    Angela M Verdoni
    Department of Medical Genetics, University of Wisconsin Madison, Madison, WI, 53706, USA
    Mamm Genome 21:64-76. 2010
    ..Our results demonstrate that Srf is essential for the actin-mediated sealing of epithelial cell-cell contacts and the development of functional stratified skin epithelium in vivo...
  86. ncbi Anthropometric analysis of eyebrows and eyelids: an inter-racial study
    Jayanth Kunjur
    Maxillofacial Unit, Poole Hospital NHS Trust, Longfleet Road, Poole, Dorset, BH15 2JB, UK
    Br J Oral Maxillofac Surg 44:89-93. 2006
    ..The measurements differ, however, among different ethnic groups. We studied the position of the eyebrow and eyelids in three different racial groups, white, Indian, and Chinese...
  87. ncbi Effects of common topical antiglaucoma medications on the ocular surface, eyelids and periorbital tissue
    J Javier Servat
    William Beaumont Eye InstituteConsultants in Ophthalmic and Facial Plastic Surgery, Royal Oak, Michigan, USA
    Drugs Aging 28:267-82. 2011
    ..This article reviews the ocular adverse effects associated with the various classes of topical antiglaucoma drugs, with a particular focus on the ocular surface, eyelids and periorbital tissue.
  88. ncbi Ectropion and entropion
    P Vallabhanath
    University of California, San Francisco, USA
    Curr Opin Ophthalmol 11:345-51. 2000
    ..Surgical correction should be directed to the anatomic changes present. A detailed discussion of the more useful surgical procedures to correct ectropion and entropion is presented...
  89. ncbi Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC)
    Tuula Rinne
    Department of Human Genetics, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Am J Med Genet A 149:1948-51. 2009
    ..However, AEC and RHS mutations in the 5' and 3' ends of the p63 gene point towards a critical role of the DeltaNp63alpha isoform for the AEC/RHS phenotype...
  90. ncbi In vivo confocal microscopy of the palpebral conjunctiva and tarsal plate
    Nathan Efron
    Institute of Health and Biomedical Innovation and School of Optometry, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Optom Vis Sci 86:E1303-8. 2009
    ..The aim of this work is to develop a more complete understanding of the in vivo histology of the human palpebral conjunctiva and tarsal plate...
  91. ncbi Approximation of the eyelids using Steri-Strips for effective eye closure
    Danish Imran
    Plast Reconstr Surg 113:1518-9. 2004
  92. ncbi The influence of eyelid morphology on normal corneal shape
    Scott A Read
    Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
    Invest Ophthalmol Vis Sci 48:112-9. 2007
    To investigate associations between the topography of the cornea and the morphology of the eyelids in a population of young adult subjects with a range of refractive errors.
  93. ncbi Medial horn supporting ligament in Asian upper eyelids
    Hirohiko Kakizaki
    Department of Ophthalmology, Aichi Medical University, Nagakute cho, Aichi Gun, Aichi Ken, Japan
    Orbit 27:91-6. 2008
    ..In all eyelids in the gross cadaveric samples, the MHSL was attached from the superior to the medial surfaces of the medial horn,..
  94. ncbi Relationship between the axis and degree of high astigmatism and obliquity of palpebral fissure
    M Lourdes Garcia
    Department of Pediatric Ophthalmology and the Center for Genetic Eye Diseases, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J AAPOS 7:14-22. 2003
    ..To investigate a possible relationship between the slanting of palpebral fissures and the magnitude and axis of astigmatism in children with astigmatism...
  95. ncbi Relationships between central tear film thickness and tear menisci of the upper and lower eyelids
    Jianhua Wang
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:4349-55. 2006
    To investigate the relationship between central tear film thickness (TFT) and tear menisci of the upper and lower eyelids using real-time optical coherence tomography (OCT).
  96. ncbi Changes in astigmatism after surgery for epiblepharon in highly astigmatic children: a controlled study
    Mo Sae Kim
    Department of Ophthalmology, Sungkyunkwan University, School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea
    J AAPOS 12:597-601. 2008
    ..To evaluate changes in astigmatism after corrective surgery in highly astigmatic epiblepharon patients compared with nonepiblepharon patients...
  97. ncbi Bilateral basal cell carcinoma symmetrically appearing on lower eyelids: a case report
    I Askar
    Department of Plastic and Reconstructive Surgery, Medical School, Dicle University, Diyarbakir, Turkey
    Acta Chir Plast 45:49-51. 2003
    ..There has been no literature about bilateral basal cell carcinoma of lower eyelids symmetrically. A 68-year-old male patient had been suffering from two lesions on his lower eyelids for two years...
  98. ncbi Morphologic and volumetric studies of the meibomian glands in elderly human eyelids
    Igor Kozak
    University of California San Diego, Shiley Eye Center, La Jolla, CA 92037, USA
    Cornea 26:610-4. 2007
    ..To study the microscopic structure of postmortem human Meibomian glands (MGs) in the elderly...
  99. ncbi Necrosis of the eyelids and sclera after retrobulbar anesthesia
    Ashok Sharma
    Cornea Clinic, Grewal Eye Institute, Chandigarh, India
    J Cataract Refract Surg 29:842-4. 2003
    ..This is a previously unreported complication of retrobulbar anesthesia comprising ophthalmic artery occlusion with scleral melt, ocular ischemia, and eyelid necrosis...
  100. ncbi Regression of lid-induced corneal topography changes after reading
    Michael J Collins
    Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Victoria Park Road, Kelvin Grove 4059, Brisbane, Australia
    Optom Vis Sci 82:843-9. 2005
    ..The purpose of this article is to investigate the magnitude of lid-induced corneal topography changes as a function of time spent reading and the subsequent time course of regression of these changes...
  101. ncbi Congenital bilateral eversion of the eyelids
    Michaeline A Isawumi
    Department of Ophthalmology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun State, Nigeria
    J Pediatr Ophthalmol Strabismus 45:371-3. 2008
    The authors report a case of congenital bilateral eversion of the eyelids with secondary conjunctival prolapse in a 4-hour-old neonate...

Research Grants52

  1. Mouse model for eyelid disease: Congenital blepharophimosis
    Chia Yang Liu; Fiscal Year: 2013
    ..dominant genetic disorder characterized by craniofacial defects that mainly affect the development of the eyelids. There are two types of BPES: Type I consists of the four major features of blepharophimosis, ptosis, epicanthus ..
  2. Modification of AdenoAssociated Virus to deliver DNA directly to Mitochondria
    John Guy; Fiscal Year: 2011
    ..Almost all of them involve ocular structures that include the optic nerve, retina, extraocular muscles or eyelids. The most common of these is Leber Hereditary Optic Neuropathy (LHON) caused (in half the cases) by a mutated ND4 ..
  3. Cellular and Developmental Function of Mena
    Frank B Gertler; Fiscal Year: 2012
    ..of these events are fusion and zippering closed of the neural tube, of the two secondary palates, and of the eyelids as the eyes close part way through gestation;embryos deficient in Ena/VASP exhibit all of these defects...
  4. The Role of MAP 3 kinase 1 in Ocular Surface Morphogenesis
    Ying Xia; Fiscal Year: 2012
    ..Vertebrate eyelid morphogenesis undergoes a common process of transient eyelid closure, resulting in closed eyelids that enclose a mucin-enriched conjunctiva sac protecting corneal maturation and development...
  5. Staph keratitis: mechanism and arrest of ocular damage
    RICHARD JOSEPH O'CALLAGHAN; Fiscal Year: 2012
    ..This organism commonly infects the eyelids and conjunctiva and causes sight-threatening infections of the cornea...
  6. Individually tailored lighting system to improve sleep in older adults
    MARIANA FIGUEIRO; Fiscal Year: 2013
    ..LRC) at Rensselaer Polytechnic Institute showed that monochromatic 530-nm (green) light delivered through the eyelids before predicted minimum core body temperature (CBTmin) acutely suppressed melatonin and delayed dim light ..
  7. 2010 Biology and Pathobiology of The Cornea
    Shukti Chakravarti; Fiscal Year: 2010
    ..Unlike other barrier tissues of the body, the cornea and supporting adnexa (eyelids, conjunctiva, meibomian glands, lacrimal glands) have evolved distinctive mechanisms to maintain transparency and ..
  8. CONTROL OF EYELIDS IN NORMAL AND PATHOLOGICAL STATES
    LESLIE CRAIG EVINGER; Fiscal Year: 2011
    ..The results of these investigations may point to future treatment options for symptoms that plague individuals with BEB, dry eye and migraine. ..
  9. Treating sleep disruption in teens with millisecond light exposure during sleep
    Jamie M Zeitzer; Fiscal Year: 2013
    ..That is, the flashes can be administered during sleep and the light will penetrate closed eyelids. When light is administered in such a manner, it does not disturb sleep...
  10. MEIBOMIAN KERATOCONJUNCTIVITIS
    James McCulley; Fiscal Year: 1999
    ..Symptoms can include crusting of the lid margin, itching and burning eyelids, or lid inflammation and swelling, but signs can also include conjunctival inflammation and localized corneal ..
  11. CHEMOMYECTOMY FOR EYELID SPASMS
    Linda McLoon; Fiscal Year: 1999
    ..Doxorubicin (DXN), a potent anti-metabolic and anti-mitotic cancer drug, is injected directly into the eyelids. In laboratory studies injection of DXN results in a loss of up to 70% of the muscle fibers in the orbicularis ..
  12. BIOMIMETIC TISSUES--ORAL MUCOSACONJUNCTIVA, AND SKIN
    Jackie Bickenbach; Fiscal Year: 2002
    ..Like the tissues in the oral cavity, the conjunctiva is a mucosal tissue that lines the eye and the eyelids. It is comprised of a non-keratinizing stratified squamous epithelium, similar to the buccal mucosa...
  13. THE DEVELOPMENT OF THE EYE AND ITS ADNEXA
    ANTHONY PEARSON; Fiscal Year: 1980
    ..will be on the development of the eye and the cranial nerves related to it, the orbit and its contents, the eyelids, and the lacrimal apparatus...
  14. Use of Electrostatic Actuators for 3D Laparoscopy
    Scott Goodwin; Fiscal Year: 2005
    ..opto-mechanical mounting subsystem, and a high-voltage electronic driving board to control the position of the eyelids in the array...
  15. K12 Expression: Cornea-Type Epithelial Differentiation
    WINSTON KAO; Fiscal Year: 2008
    ..Aim 3 is to examine roles of Fos on corneal-type epithelium differentiation and corneal wound healing as described in Aim 2. ..
  16. RPE-Mphi Binding: Ca++_&O2-_Dependent AMD Responses
    Victor Elner; Fiscal Year: 2008
    ..This new knowledge is likely to lead to advances in therapy, which may stem or prevent AMD. ..
  17. Elevated potassium ion in lacrimal fluid and the health of the ocular surface
    John Ubels; Fiscal Year: 2009
    ..If the high potassium in tears is important for the health of the ocular surface, this information will be useful in the development of improved treatments for dry eye disease. ..
  18. Analysis of Lacrimal Gland by Laser Microdissection
    John Ubels; Fiscal Year: 2003
    ..abstract_text> ..
  19. Mice Overexpressing rtTA and Cre in Corneal Epithelium
    WINSTON KAO; Fiscal Year: 2004
    ..These mouse lines will be useful in preparing mouse lines for studies of altered genetic functions from the corneal epithelium-specific gene ablation and overexpression of reporter genes. ..
  20. 2007 Oculomotor System Biology Gordon Research Conference
    Neeraj Gandhi; Fiscal Year: 2007
    ..Other disorders such as congenital fibrosis can also alter mechanistic properties of the extraocular muscle itself. Hence, the oculomotor system is of immense relevance to health. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. Structure/Function Relationship of The Lumican Gene
    Winston W Kao; Fiscal Year: 2010
    ..g., persistent and excessive inflammation, corneal transparency of injured cornea, improved wound healing of diabetes, etc. ..
  22. 2005 (Oculomotor System Biology) Gordon Conference
    Neeraj Gandhi; Fiscal Year: 2005
    ..Hence, we seek to bring together ideas and investigators that are not often at the same venue. ..
  23. THE ROLE OF RETINOIDS IN LACRIMAL GLAND FUNCTION
    John Ubels; Fiscal Year: 2002
    ..abstract_text> ..
  24. INTERMEDIATE CEREBELLUM IN ADAPTIVE REFLEX CONTROL
    Vlastislav Bracha; Fiscal Year: 2010
    ....
  25. NEURAL CONTROL OF THE REACH-TO-GRASP
    Alan Gibson; Fiscal Year: 2001
    ..Knowledge of how the nervous system controls movement will help us understand, and possibly treat, the diseases and injuries that affect movement and detract from the lives of many people. ..
  26. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  27. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  28. A novel therapeutic for the treatment of persistent corneal epithelial defects
    Bennie H Jeng; Fiscal Year: 2010
    ..the use of bandage soft contact lenses, pressure patching, punctal plugging, and the surgical closure of the eyelids. Unfortunately, the success rates with these conventional treatment modalities are varied, and overall, ..
  29. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ....
  30. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2003
    ..abstract_text> ..
  31. Surgical Management of Facial Nerve Injury
    Theresa Hadlock; Fiscal Year: 2007
    ..The academic environment is one of complete dedication to advancing both biomedical science and patient care through careful study and diligent investigation, and of support for the mentored investigator. [unreadable] [unreadable]..
  32. Retinoid Dehydrogenases Involved in Eye Development
    GREGG L DUESTER; Fiscal Year: 2010
    ....
  33. Mechanisms of Sympathetic Axon Pruning
    Peter G Smith; Fiscal Year: 2010
    ..Findings will be pertinent to understanding both organizing principles related to normal nervous system plasticity, and to disturbances in innervation in certain disease states. ..
  34. Schizophrenia Predisposition in 22q11 Deletion Syndrome
    Vandana Shashi; Fiscal Year: 2005
    ..abstract_text> ..
  35. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  36. 2005 Tissue Repair and Regeneration Gordon Conferences
    Paul Martin; Fiscal Year: 2005
    ..The combination of speakers and topics has been selected with the specific intention of stimulating new ideas and collaborations in the field of tissue repair. ..
  37. NGF and Post-Infarct Sympathetic Neuroplasticity
    Peter Smith; Fiscal Year: 2009
    ....
  38. The Contact Lens and Dry Eye Study
    Jason Nichols; Fiscal Year: 2006
    ..The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for contact lens-related dry eye so that progress can be made toward its prevention. ..
  39. Genetic analysis of congenital diaphragmatic hernia
    Anne Slavotinek; Fiscal Year: 2006
    ..abstract_text> ..
  40. Planning Grant:Research on Blinding Eye Diseases (RMI)
    Darlene Dartt; Fiscal Year: 2006
    ..Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared. [unreadable] [unreadable]..
  41. Artificial Cornea Based on Photolithographically Patterned, Biomimetic Hydrogels
    Christopher N Ta; Fiscal Year: 2010
    ..3. Determine the skirt design for optimal stromal tissue integration by evaluating in vitro and in vivo stromal wound healing within photolithographically patterned, microperforated hydrogel arrays. ..
  42. Ontogenetic Changes in Control of Rhythmicity in rabbits
    Mario Caba; Fiscal Year: 2008
    ..g. jet lag, shift work. Once characterized, we can use this information to control circadian rhythms in circumstances where it is disrupted. ..
  43. The Reinforcing Mechanisms of Smoking in Adult ADHD
    JEAN GEHRICKE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. SPECTROSCOPIC AND RELATED STUDIES ON LENS MEMBRANE LIPID
    Douglas Borchman; Fiscal Year: 2003
    ..An understanding of these alterations will facilitate the development of therapies to prevent or perhaps even reverse these changes. ..
  45. Characterization of Tear Dynamics
    Jianhua Wang; Fiscal Year: 2007
    ..be developed is based on a precise and rapidly repeated cross-section of the tear over the cornea and around the eyelids, using a newly developed real-time optical coherence tomographer (OCT)...
  46. Signaling Mechanisms of TCDD-induced AHR Activation
    Ying Xia; Fiscal Year: 2007
    ..abstract_text> ..
  47. MEIBOMIAN KERATOCONJUNCTIVITIS
    James McCulley; Fiscal Year: 2003
    ..several different and overlapping arrays of signs and symptoms (crusting of lid margin, itching and burning eyelids, lid inflammation, swelling, conjunctival inflammation, localized corneal damage)...
  48. NEURONAL INTEGRATION IN CEREBELLAR SYSTEMS
    Vlastislav Bracha; Fiscal Year: 2004
    ....
  49. Transcriptional profiling in childhood diseases
    William Craigen; Fiscal Year: 2006
    ..These results will help in counseling, the development of potential therapies, and assessing long-term outcomes. ..
  50. NEUROTROPHINS, HORMONES AND POSTPAROUS INCONTINENCE
    Peter Smith; Fiscal Year: 2004
    ....
  51. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2007
    ..The results will provide a deeper understanding of how the basal ganglia and cerebellum interact to control limb movements and will lead to new approaches for the treatment of movement disorders. ..