conjunctiva

Summary

Summary: The mucous membrane that lines the inner surface of the eyelids and the anterior part of the sclera.

Top Publications

  1. ncbi A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride
    Cuiju Xiong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 49:1850-6. 2008
  2. ncbi Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines
    Ilene K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:2496-506. 2003
  3. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
  4. ncbi Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells
    C Debbasch
    Unit of Cellular Pharmacotoxicology, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, the Toxicology Laboratory, University of Paris-V, France
    Invest Ophthalmol Vis Sci 42:642-52. 2001
  5. pmc IL-17 disrupts corneal barrier following desiccating stress
    C S de Paiva
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    Mucosal Immunol 2:243-53. 2009
  6. pmc Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract
    Michael C W Chan
    Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Pathol 176:1828-40. 2010
  7. pmc Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology
    L Solano-Gallego
    Departament de Farmacologia i Terapeutica, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    J Clin Microbiol 39:560-3. 2001
  8. ncbi A mouse model of keratoconjunctivitis sicca
    Dilek Dursun
    Ocular Surface and Tear Center, Bascom Palmer Eye Institute, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:632-8. 2002
  9. pmc Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses
    Gargi Dasgupta
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California at Irvine, California
    Invest Ophthalmol Vis Sci 52:3321-33. 2011
  10. pmc Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection
    Angels Natividad
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
    Infect Immun 78:4895-911. 2010

Detail Information

Publications288 found, 100 shown here

  1. ncbi A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride
    Cuiju Xiong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 49:1850-6. 2008
    ..To establish a rabbit dry eye model with topical medication of the ocular preparation preservative benzalkonium chloride (BAC)...
  2. ncbi Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines
    Ilene K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:2496-506. 2003
    ..The purpose of this work was to characterize newly developed immortalized corneal and conjunctival cell lines using mucin gene expression as markers of differentiation...
  3. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
    ....
  4. ncbi Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells
    C Debbasch
    Unit of Cellular Pharmacotoxicology, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, the Toxicology Laboratory, University of Paris-V, France
    Invest Ophthalmol Vis Sci 42:642-52. 2001
    ..Superoxide anions may play an important role in tissue damage induced by preservatives in ocular surface disorders...
  5. pmc IL-17 disrupts corneal barrier following desiccating stress
    C S de Paiva
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    Mucosal Immunol 2:243-53. 2009
    ..Gene expression in the human DE conjunctiva showed increased levels of the Th-17 inducers, interleukin (IL)-23, IL-17A, and interferon-gamma (IFN-gamma)...
  6. pmc Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract
    Michael C W Chan
    Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Pathol 176:1828-40. 2010
    ..host-responses elicited by pandemic H1N1pdm and seasonal H1N1 influenza viruses in ex vivo cultures of human conjunctiva, nasopharynx, bronchus, and lung, as well as in vitro cultures of human nasopharyngeal, bronchial, and alveolar ..
  7. pmc Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology
    L Solano-Gallego
    Departament de Farmacologia i Terapeutica, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    J Clin Microbiol 39:560-3. 2001
    ..the titer of anti-Leishmania antibodies, and investigated the presence of Leishmania DNA by PCR in skin, conjunctiva, and bone marrow samples of each dog...
  8. ncbi A mouse model of keratoconjunctivitis sicca
    Dilek Dursun
    Ocular Surface and Tear Center, Bascom Palmer Eye Institute, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:632-8. 2002
    ....
  9. pmc Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses
    Gargi Dasgupta
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California at Irvine, California
    Invest Ophthalmol Vis Sci 52:3321-33. 2011
    ..that Foxp3(+)CD4(+) CD25(+(Bright)) "natural" regulatory T cells (nT(reg) cells) are abundant in rabbit conjunctiva and suppress herpes simplex virus (HSV)-1-specific CD4(+) and CD8(+) effector T cells (T(eff) cells)...
  10. pmc Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection
    Angels Natividad
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
    Infect Immun 78:4895-911. 2010
    ..The data suggest that in addition to polymorph and adaptive cellular responses, NK cells may contribute to a significant component of the conjunctival inflammatory response to chlamydial infection...
  11. ncbi Fibrin glue versus sutures for conjunctival autografting in pterygium surgery: a prospective comparative study
    A Karalezli
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Br J Ophthalmol 92:1206-10. 2008
    ..To compare the use of fibrin glue versus sutures for fixating conjunctival autografts in patients undergoing pterygium excision...
  12. ncbi A novel bubble liposome and ultrasound-mediated gene transfer to ocular surface: RC-1 cells in vitro and conjunctiva in vivo
    Toshifumi Yamashita
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Science, Sakuragaoka, Kagoshima, Kagoshima 890 8520, Japan
    Exp Eye Res 85:741-8. 2007
    ..In rat eyes, strong GFP staining was seen in conjunctiva of BLUS group (average: 3.6)...
  13. ncbi Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca
    S C Pflugfelder
    Ocular Surface and Tear Center Bascom Palmer Eye Institute University of Miami School of Medicine Department of Ophthalmology Miami, FL 33136, USA
    Curr Eye Res 19:201-11. 1999
    ..To compare epidermal growth factor (EGF) concentration in tear fluid and levels of inflammatory cytokines in the conjunctival epithelium of patients with Sjögren's syndrome keratoconjunctivitis sicca with those of normal controls...
  14. ncbi In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line
    Emmanuelle Brasnu
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Curr Eye Res 33:303-12. 2008
    ....
  15. ncbi Quantitative analysis of conjunctival goblet cells after chronic application of topical drops
    Malik Y Kahook
    University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Adv Ther 25:743-51. 2008
    ..02% benzalkonium chloride (BAK) eye drops (Xalatan; Pfizer, NY, USA), travoprost preserved with sofZia eye drops (Travatan Z; Alcon, Fort Worth, TX, USA), or preservative-free artificial tears (Refresh Plus; Allergan, Irvine, CA, USA)...
  16. pmc Conjunctival transcriptome in scarring trachoma
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 79:499-511. 2011
    ....
  17. ncbi Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term
    Christophe Baudouin
    Department of Ophthalmology, Quinze Vingts National Ophthalmology Hospital, APHP, Paris Ouest School of Medicine, University of Versailles, Paris, France
    Ophthalmology 111:2186-92. 2004
    ..To compare the conjunctival epithelial cell expressions of inflammatory cytokines in normal subjects and in glaucoma patients treated over the long term...
  18. pmc Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation
    Darlene A Dartt
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:4455-66. 2011
    The conjunctiva is a mucous membrane that covers the sclera and lines the inside of the eyelids. Throughout the conjunctiva are goblet cells that secrete mucins to protect the eye...
  19. ncbi Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue
    Philipp Steven
    Eye Hospital, University of Lubeck, Lubeck, Germany
    Invest Ophthalmol Vis Sci 49:1512-7. 2008
    b>Conjunctiva-associated lymphoid tissue (CALT) is assumed to be a key location for the generation of adaptive immune mechanisms of the ocular surface, but functional studies of CALT are still lacking...
  20. ncbi Recurrent pterygium surgery using pterygium extended removal followed by extended conjunctival transplant: recurrence rate and cosmesis
    Lawrence W Hirst
    University of Queensland and Queensland Eye Institute, Brisbane, Australia
    Ophthalmology 116:1278-86. 2009
    ..To assess the rate of recurrence, complications, and cosmesis after recurrent pterygium removal with P.E.R.F.E.C.T. for PTERYGIUM (Pterygium Extended Removal Followed by Extended Conjunctival Transplant)...
  21. pmc Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
    Hong Liang
    Paris Descartes University, Faculty of Biological and Pharmacological Sciences, Department of Toxicology, Paris, France
    Mol Vis 15:1690-9. 2009
    ..005% latanoprost, 0.004% travoprost, 0.03% bimatoprost (containing 0.02%, 0.015%, and 0.005% BAC, respectively), and 0.005% latanoprost in a new cationic emulsion (LCEm) formulation...
  22. ncbi Live conjunctiva-associated lymphoid tissue analysis in rabbit under inflammatory stimuli using in vivo confocal microscopy
    Hong Liang
    Department of Toxicology, Faculty of Biological and Pharmacological Sciences, Paris Descartes University, Paris, France
    Invest Ophthalmol Vis Sci 51:1008-15. 2010
    b>Conjunctiva-associated lymphoid tissue (CALT) plays an important role in ocular surface immunity. No study until now has been able to show its in vivo aspects, and few have demonstrated its reactions after pathologic patterns...
  23. ncbi Sutureless human sclera donor patch graft for Ahmed glaucoma valve
    Lucio Zeppa
    Unità Operativa di Oculistica, Presidio Ospedaliero Giuseppe Moscati, Avellino Italy
    Eur J Ophthalmol 20:546-51. 2010
    To report the safety and effectiveness of a sutureless human sclera donor patch graft covering the subconjunctival portion of glaucoma drainage implant tube to prevent its erosion throughout the overlying conjunctiva.
  24. ncbi Topical cyclosporine in thyroid orbitopathy-related dry eye: clinical findings, conjunctival epithelial apoptosis, and MMP-9 expression
    Canan Gürdal
    Ankara Ataturk Training and Research Hospital, 2nd Ophthalmology Department, Ankara, Turkey
    Curr Eye Res 35:771-7. 2010
    To evaluate the effects of topical cyclosporine A (CsA) 0.05% (Restasis) on the signs and symptoms of dry eye, on apoptosis, and on MMP-9 expression in conjunctiva epithelial cells in thyroid orbitopathy (TO)-related dry eye patients.
  25. ncbi Needling revision of trabeculectomies bleb morphology and long-term survival
    Alan P Rotchford
    Department of Ophthalmology, Queen s Medical Centre, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom
    Ophthalmology 115:1148-1153.e4. 2008
    ..To assess the long-term success rate and to determine factors that predict survival after 5-fluorouracil-augmented needling revision of poorly functioning trabeculectomy blebs...
  26. ncbi Antigen from the anterior chamber of the eye travels in a soluble form to secondary lymphoid organs via lymphatic and vascular routes
    Serge Camelo
    School of Anatomy and Human Biology, The University of Western Australia, Crawley Perth
    Invest Ophthalmol Vis Sci 47:1039-46. 2006
    ..To determine the afferent pathways linking the anterior chamber (AC) of the eye to the secondary lymphoid organs...
  27. ncbi Increased oxidative DNA damage, 8-hydroxydeoxy- guanosine, in human pterygium
    H C Kau
    Department of Ophthalmology, Taoyuan Veterans Hospital, Taoyuan, Taiwan
    Eye (Lond) 20:826-31. 2006
    ..UV radiation may induce production of reactive oxygen species via photosensitized oxidation, thus causing oxidative damage. This study was conducted to test the hypothesis that oxidative damage to DNA is increased in pterygium...
  28. ncbi The controlled-environment chamber: a new mouse model of dry eye
    Stefano Barabino
    Laboratory of Immunology, Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:2766-71. 2005
    ..To develop a controlled-environment chamber (CEC) for mice and verify the effects of a low-humidity setting on ocular surface signs in normal mice...
  29. ncbi Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 44:1998-2003. 2003
    ..Hence, studying the mechanism by which CTGF influences TGF-beta1-induced synthesis of collagen in conjunctiva of patients with OCP would provide insight into the mechanism of conjunctival fibrosis in patients with OCP.
  30. ncbi A murine model of dry eye induced by an intelligently controlled environmental system
    Wei Chen
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 49:1386-91. 2008
    ..To establish a novel murine model of dry eye using an intelligently controlled environmental system (ICES)...
  31. pmc Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice
    Cintia S de Paiva
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Rheumatology (Oxford) 49:246-58. 2010
    ..The objective of this study was to evaluate the severity of corneal epithelial disease and T-cell cytokine profile in the ocular surface tissues of CD25KO mice...
  32. ncbi Levels of mucin gene expression in normal human conjunctival epithelium in vivo
    R M Corrales
    Ocular Surface Unit, Instituto Universitario de Oftalmobiologia Aplicada IOBA, University of Valladolid, Valladolid, Spain
    Curr Eye Res 27:323-8. 2003
    ..Conjunctival impression cytology (CIC) samples were used to determine the mean and normal range of mRNA levels of human MUC1, MUC2, MUC4, MUC5AC, and MUC7 mucin genes...
  33. pmc A randomised controlled trial of azithromycin following surgery for trachomatous trichiasis in the Gambia
    M J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Br J Ophthalmol 89:1282-8. 2005
    ..This study investigates whether enhanced control of infection, both of Chlamydia trachomatis and other bacteria, with azithromycin can improve surgical outcome in a trachoma control programme...
  34. ncbi Active matrilysin (MMP-7) in human pterygia: potential role in angiogenesis
    N Di Girolamo
    Inflammation Research Unit, School of Pathology, University of New South Wales, Sydney, New South Wales, Australia
    Invest Ophthalmol Vis Sci 42:1963-8. 2001
    ..The purpose of this study was to determine the cellular distribution and activation status of matrilysin (MMP-7) in pterygia...
  35. ncbi Apoptosis of ocular surface cells in experimentally induced dry eye
    Steven Yeh
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 44:124-9. 2003
    ..To evaluate to effect of experimental dry eye on ocular surface apoptosis...
  36. ncbi Allergic conjunctivitis: update on pathophysiology and prospects for future treatment
    Santa Jeremy Ono
    Department of Immunology, University College London, Institutes of Ophthalmology and Child Health and Moorfields Eye Hospital, NHS Trust, United Kingdom
    J Allergy Clin Immunol 115:118-22. 2005
    ....
  37. ncbi [A new approach for better comprehension of diseases of the ocular surface]
    C Baudouin
    Centre National d Ophtalmologie des Quinze Vingts, Paris, France
    J Fr Ophtalmol 30:239-46. 2007
    ..or diffuse hyperosmolarity of the tear film and therefore of superficial epithelial cells of the cornea and/or conjunctiva, stimulating epithelial cells and resident inflammatory cells...
  38. ncbi Current concepts and techniques in pterygium treatment
    Leonard P K Ang
    Singapore National Eye Centre, Singapore
    Curr Opin Ophthalmol 18:308-13. 2007
    ..The purpose of this review is to summarize the more recent and relevant studies on pterygium treatment...
  39. pmc Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome
    Suksri Chotikavanich
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 50:3203-9. 2009
    ..To evaluate production and activity of metalloproteinase (MMP)-9 on the ocular surface of patients with dysfunctional tear syndrome (DTS) and determine any correlation between MMP-9 activity and clinical parameters...
  40. ncbi Prevalence of ocular surface disease in glaucoma patients
    Eamon W Leung
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093 0946, USA
    J Glaucoma 17:350-5. 2008
    ..To examine the prevalence of ocular surface disease (OSD) in glaucoma patients...
  41. ncbi Polymerase chain reaction using noninvasively obtained samples, for the detection of Leishmania infantum DNA in dogs
    Dalit Strauss-Ayali
    School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel
    J Infect Dis 189:1729-33. 2004
    ..PCR using noninvasively obtained conjunctival samples will be useful for epidemiological studies and for direct diagnosis of canine visceral leishmaniasis...
  42. ncbi Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye
    Michael E Stern
    llergan, Inc, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 43:2609-14. 2002
    To examine the conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca (SS-KCS) and non-Sjögren's keratoconjunctivitis sicca (NS-KCS) for evidence of immune-based inflammation.
  43. pmc The role of eye-associated lymphoid tissue in corneal immune protection
    Erich Knop
    Research Laboratory of the Eye Clinic CVK, Charite University School of Medicine, Berlin, Germany
    J Anat 206:271-85. 2005
    ..Its main support tissue is the conjunctiva, in addition to the lacrimal gland, the latter which provides soluble mediators via the tear film...
  44. pmc Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
    H Liang
    Department of Toxicology, Faculty of Biological and Pharmacological Sciences, University Paris Descartes, Paris, France
    Br J Ophthalmol 92:1275-82. 2008
    ..To compare the conjunctival and corneal reactions of commercially available solution of latanoprost (Xalatan) and preservative-free (PF) tafluprost in rabbits...
  45. ncbi Modulation of wound healing after glaucoma surgery
    P T Khaw
    Wound Healing Research Unit, Department of Pathology, Institute of Ophthalmology and Moorfields Eye Hospital, London, England
    Curr Opin Ophthalmol 12:143-8. 2001
    ..The authors review the changes in how to use antimetabolites to improve safety, and many of the exciting new areas of progress, including growth factor neutralization and future molecular therapies to control wound healing...
  46. ncbi Patterns of cytokeratin and vimentin expression in the human eye
    M Kasper
    Institute of Pathology, District Hospital Görlitz, German Democratic Republic
    Histochemistry 89:369-77. 1988
    ..The occurrence of the expression of simple-epithelium CKs in the ciliary and pigment epithelium demonstrates that, despite their neuroectodermal derivation, these are true epithelia...
  47. ncbi Sensitivity and specificity of a point-of-care matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye
    Robert Sambursky
    Manatee Sarasota Eye Clinic and Laser Center, Sarasota, Bradenton, FL 34202, USA
    JAMA Ophthalmol 131:24-8. 2013
    ..To determine the clinical sensitivity, specificity, negative predictive value, and positive predictive value of a rapid point-of-care diagnostic test to detect elevated matrix metalloproteinase 9 levels (InflammaDry)...
  48. ncbi Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition
    Hsiao Sang Chu
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
    Cornea 30:60-6. 2011
    ..To determine the effects on corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab in patients who had NV associated with lipid keratopathy...
  49. pmc Validation of endogenous control genes for gene expression studies on human ocular surface epithelium
    Bina Kulkarni
    Division of Ophthalmology and Visual Sciences, Queen s Medical Centre, Nottingham, United Kingdom
    PLoS ONE 6:e22301. 2011
    ..genes in the ocular surface (OS) epithelial regions including cornea, limbus, limbal epithelial crypt and conjunctiva to normalise the quantitative reverse transcription PCR data of genes of interest expressed in above-mentioned ..
  50. ncbi Assessment of bleb morphologic features and postoperative outcomes after Ex-PRESS drainage device implantation versus trabeculectomy
    Travis J Good
    Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Ophthalmol 151:507-13.e1. 2011
    ..To investigate bleb morphologic features and postoperative outcomes after Ex-PRESS drainage device (Alcon Laboratories) implantation versus trabeculectomy...
  51. ncbi Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis
    Andrea Leonardi
    Department of Ophthalmology, University of Padua, via Foscari 8, 35127 Padua, Italy
    Ophthalmology 110:487-92. 2003
    ..The purpose of this study was to measure these chemokines in tear and mucus samples of active-disease patients and in vitro cultured conjunctival epithelial cells and fibroblasts...
  52. ncbi Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models
    Piera Versura
    Ophthalmology Unit, University of Bologna, Bologna, Italy
    Invest Ophthalmol Vis Sci 52:5488-96. 2011
    ..To investigate the immune response of human conjunctival epithelium to hyperosmolar stress...
  53. ncbi Defensins HNP1 and HBD2 stimulation of wound-associated responses in human conjunctival fibroblasts
    Jing Li
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 47:3811-9. 2006
    ..To study the responses of human conjunctival fibroblasts (HCFs) to stimulation by human neutrophil defensin 1 (HNP1) and beta defensin2 (HBD2)...
  54. ncbi Mucins and ocular signs in symptomatic and asymptomatic contact lens wear
    Monica Berry
    University of Bristol, Academic Unit of Ophthalmology, Bristol, United Kingdom
    Optom Vis Sci 85:E930-8. 2008
    ..As the mucus layer is a protector of the ocular surface tissue, this study investigates whether any alterations of mucins are detectable comparing symptomatic and asymptomatic soft contact lens wearers...
  55. ncbi [Eye-associated lymphoid tissue (EALT) is continuously spread throughout the ocular surface from the lacrimal gland to the lacrimal drainage system]
    E Knop
    Augenklinik Forschungslabor, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum
    Ophthalmologe 100:929-42. 2003
    Components of the mucosal immune system (MALT) have been identified in the conjunctiva (as CALT) and the lacrimal drainage system (as LDALT)...
  56. pmc Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling
    Flavio Mantelli
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:2666-72. 2009
    ..This study aimed to identify the repertoire of genes (glycogenes) involved in biosynthesis of glycoconjugates in conjunctiva of normal subjects and patients with dry eye.
  57. ncbi Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes
    Maurizio Rolando
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Cornea 24:951-4. 2005
    To examine the expression of HLA-DR, a marker of inflammation, in the early stages of dry eye disease and to locate the appearance of this marker on specific areas of the bulbar conjunctiva.
  58. ncbi Lubricating agents differ in their protection of cultured human epithelial cells against desiccation
    Katharina Paulsen
    Institute of Anatomy and Cell Biology, Ernst Moritz Arndt University, Ferdinand Sauerbruch Strasse, Greifswald, Germany
    Med Sci Monit 14:PI12-16. 2008
    ..In dry eye, as a disease of the ocular surface, the instillation of artificial tears should compensate for the deficit in wetting and protect the mucosa against drying...
  59. ncbi Cell populations and adhesion molecules expression in conjunctiva before and after bone marrow transplantation
    B Rojas
    Hilles Immunology Laboratory, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Exp Eye Res 81:313-25. 2005
    ..We were interested to analyse the composition of the cellular infiltrate and adhesion molecules expression in the conjunctiva before and at least one hundred days after autologous and allogenic bone marrow transplantation (BMT) and its ..
  60. ncbi PCR diagnosis of visceral leishmaniasis in asymptomatic dogs using conjunctival swab samples
    Rodrigo Souza Leite
    Centro de Desenvolvimento da Tecnologia Nuclear CDTN, Cidade Universitária Campus da UFMG, 31120 970, Belo Horizonte, MG, Brazil
    Vet Parasitol 170:201-6. 2010
    ..CS samples the kDNA PCR-hybridization was able to detected parasite DNA in 24/30 dogs (80%) using the right conjunctiva (RC) and 23/30 dogs (76.6%) with the left conjunctiva (LC), 17/30 dogs (56.7%) by means of SB and 4/30 dogs (13...
  61. ncbi Differential cell proliferation, apoptosis, and immune response in healthy and evaporative-type dry eye conjunctival epithelia
    Roberto Reinoso
    Ocular Surface Group, Institute for Applied Ophthalmobiology, Valladolid, Spain
    Invest Ophthalmol Vis Sci 52:4819-28. 2011
    ..The effect of topical treatment and correlations between clinical symptoms and signs and epithelial and immune variables were also determined...
  62. ncbi Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo model
    Hiroki Urashima
    Ako Research Institute, Division of Dermatologicals and Ophthalmologicals, Otsuka Pharmaceutical Co, Ltd, Hyogo 678 0207, Japan
    Cornea 23:613-9. 2004
    ..We aimed to determine the effects of rebamipide on the amount of mucin-like substances in the conjunctiva and cornea of N-acetylcysteine-treated eyes...
  63. ncbi Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial
    S Srinivasan
    Department of Ophthalmology, Toronto Western Hospital, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Ophthalmol 93:215-8. 2009
    ..To compare the degree of conjunctival autograft inflammation, subconjunctival haemorrhage (SCH) and graft stability following the use of sutures or fibrin glue (FG) during pterygium surgery...
  64. ncbi Late-phase reaction in ocular allergy
    Soo Hyun Choi
    UMDNJ, New Jersey Medical School, Newark, New Jersey, USA
    Curr Opin Allergy Clin Immunol 8:438-44. 2008
    ..To determine if the late-phase reaction, which commonly occurs in allergic rhinitis and asthma, is also found in ocular allergy...
  65. ncbi Transconjunctival sutureless 23-gauge vitrectomy
    Claus Eckardt
    Department of Ophthalmology, Staedtische Kliniken Frankfurt am Main Hoechst, Frankfurt, Germany
    Retina 25:208-11. 2005
  66. ncbi Bevacizumab and ocular wound healing after primary pterygium excision
    Mohammad Banifatemi
    Department of Ophthalmology, Shiraz University of Medical Sciences, Khalili Hospital, Shiraz, Iran
    J Ocul Pharmacol Ther 27:17-21. 2011
    ..The aim of this study was to evaluate the effect of subconjunctival bevacizumab on early postoperative wound healing in patients with primary pterygium excision...
  67. pmc MUC1 expression in Sjogren's syndrome, KCS, and control subjects
    Barbary Caffery
    Center for Contact Lens Research, School of Optometry, University of Waterloo, Ontario, Canada
    Mol Vis 16:1720-7. 2010
    ....
  68. pmc Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye
    Ilene K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Cornea 30:1346-52. 2011
    ....
  69. ncbi Subconjunctival and intracorneal bevacizumab injection for corneal neovascularization in lipid keratopathy
    Joo Youn Oh
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cornea 28:1070-3. 2009
    ..The purpose of this study was to evaluate the efficacy and safety of subconjunctival and corneal intrastromal bevacizumab injections on corneal neovascularization in patients with lipid keratopathy...
  70. ncbi A comparative study of tissue glue and vicryl suture for closing limbal-conjunctival autografts and histologic evaluation after pterygium excision
    Yasemin Ozdamar
    Ankara Ulucanlar Eye Research Hospital, Ankara, Turkey
    Cornea 27:552-8. 2008
    ..To compare clinical and histopathologic outcomes of tissue glue and vicryl suture to attach limbal conjunctival autografts in pterygium surgery...
  71. ncbi Gefarnate stimulates goblet cell repopulation following an experimental wound to the tarsal conjunctiva in the dry eye rabbit
    Hiroshi Toshida
    Department of Ophthalmology, LSU Eye Center, Lab for the Molecular Biology of the Ocular Surface, LSU Health Sciences Center, New Orleans, Louisiana, USA
    Adv Exp Med Biol 506:353-7. 2002
  72. ncbi Amniotic membrane transplantation with conjunctival autograft for recurrent pterygium
    Jun Shimazaki
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmology 110:119-24. 2003
    ..To study the effect of amniotic membrane transplantation (AMT) combined with either limbal autograft transplantation (LAT) or conjunctival autograft transplantation (CAT) in recurrent pterygium...
  73. ncbi Evaluation of the conjunctival swab for canine visceral leishmaniasis diagnosis by PCR-hybridization in Minas Gerais State, Brazil
    Sidney de Almeida Ferreira
    Centro de Desenvolvimento da Tecnologia Nuclear CDTN, Rua Professor Mário Werneck S No, Cidade Universitária Campus da UFMG, 31120 970 Belo Horizonte, MG, Brazil
    Vet Parasitol 152:257-63. 2008
    ..This approach can be very useful for diagnosis of canine leishmaniasis and could be applied to the follow-up and regular screening of vaccinated dogs...
  74. ncbi Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis
    Naoki Kumagai
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube City, Yamaguchi 755 8505, Japan
    Prog Retin Eye Res 25:165-87. 2006
    ..and stromal lesions as well as of conjunctival proliferative changes such as giant papillae of the upper tarsal conjunctiva and limbal lesions...
  75. ncbi Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium
    Anca Maria Cimpean
    Department of Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Oncol Rep 26:1111-3. 2011
    ..An increased lymphatic microvessel density was observed in the human pterygium compared to the normal conjunctiva. Moreover, D2-40-positive lymphatic endothelial cells were also actively proliferating, as assessed by Ki-67 ..
  76. ncbi Age-related differential expression of apoptosis-related genes in conjunctival epithelial cells
    Jurgen Giebel
    Institute of Anatomy, Ernst Moritz Arndt University, Greifswald, Germany
    Acta Ophthalmol Scand 83:471-6. 2005
    ..To investigate whether the expression of apoptosis-related genes in normal conjunctival epithelial cells is age-related (as a prerequisite to assessing whether dysregulation of apoptosis may be involved during degenerative diseases)...
  77. ncbi Immune response in the conjunctival epithelium of patients with dry eye
    Stefano Barabino
    Ocular Surface Research Center, Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Viale Benedetto XV 5, Genoa, Italy
    Exp Eye Res 91:524-9. 2010
    ..This study indicates that immune cells isolated from the superficial layer of the conjunctiva may play a pivotal role in the pathogenesis of dry eye, and that a new method of preservation of impression ..
  78. ncbi Pseudomonas aeruginosa induces interleukin-8 (IL-8) gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding protein beta to the IL-8 promoter
    Isabella Venza
    Departments of Surgical Specialties and Experimental Pathology and Microbiology, University of Messina, 98125 Messina, Italy
    J Biol Chem 284:4191-9. 2009
    ....
  79. ncbi Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 13:1730-9. 2007
    ..To examine the effects of blocking p38 mitogen-activated protein kinase (MAPK) on post-injury conjunctival scarring in mice. Its effects on the behaviors of cultured subconjunctival fibroblasts were also investigated...
  80. pmc FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate
    Jie Huang
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63130, USA
    Development 136:1741-50. 2009
    ..A second row of eyelashes is a feature of human lymphedema-distichiasis syndrome, which is associated with mutations in FOXC2...
  81. ncbi Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye
    Kohei Hironaka
    Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Japan
    J Control Release 136:247-53. 2009
    ..The liposomes tested in ocular cells showed little cytotoxicity. These results suggest that ssLip can be used to deliver drugs to the posterior segment of the eye...
  82. pmc Bacterial infection in scarring trachoma
    Victor H Hu
    International Centre for Eye Health, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Invest Ophthalmol Vis Sci 52:2181-6. 2011
    ..To assess whether non-chlamydial bacterial infection is associated with trachomatous scarring in adults...
  83. ncbi Expression of growth factors in the conjunctiva from patients with active trachoma
    A M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Eye (Lond) 20:362-9. 2006
    ..factor (CTGF) and basic fibroblast growth factor (bFGF), the angiogenic vascular endothelial growth factor (VEGF), the angiogenesis-associated endothelial cell marker CD105 (endoglin), and the ECM protein tenascin in the conjunctiva.
  84. ncbi [Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes]
    R M Corrales
    Instituto Universitario de Oftalmobiologia Aplicada IOBA, Universidad de Valladolid, Valladolid, Espana
    Arch Soc Esp Oftalmol 78:375-81. 2003
    ..This study was designed to determine the expression profile of mucin genes in conjunctival impression cytology (CIC) samples from healthy subjects...
  85. ncbi Conjunctival lymphatic system
    Daljit Singh
    J Cataract Refract Surg 29:632-3. 2003
  86. pmc In vivo confocal microscopy of trachoma in relation to normal tarsal conjunctiva
    Victor H Hu
    International Centre for Eye Health, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Ophthalmology 118:747-54. 2011
    To describe the in vivo confocal microscopy (IVCM) appearances of the tarsal conjunctiva in trachoma compared with the appearance of healthy conjunctiva and to develop grading systems for IVCM examination of the tarsal conjunctiva for ..
  87. pmc Membrane-tethered mucins have multiple functions on the ocular surface
    Bharathi Govindarajan
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 90:655-63. 2010
    ..Both animal and in vitro models for their study are herein described, as are alterations of the mucins in ocular surface disease...
  88. ncbi Conjunctivitis caused by a swine Chlamydia trachomatis-like organism in gnotobiotic pigs
    D G Rogers
    Veterinary Diagnostic Center, Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln 68583 0907, USA
    J Vet Diagn Invest 11:341-4. 1999
    ..The results indicated that chlamydial strain H7 can cause mild or occasionally moderate conjunctivitis in gnotobiotic pigs, but the conjunctival infection is asymptomatic...
  89. ncbi Exposure to a dry environment induces strain-specific responses in mice
    Stefano Barabino
    Laboratory of Immunology, Schepens Eye Research Institute, and Cornea Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 84:973-7. 2007
    ....
  90. ncbi [Expression of matrix metalloproteinase in human pterygia]
    Jun Zeng
    Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha 410011, China
    Yan Ke Xue Bao 20:242-5. 2004
    ..To determine the cellular distribution and activation of MMP-2 and MMP-9 in human pterygium...
  91. ncbi In vivo confocal microscopy of filtering blebs after trabeculectomy
    Elisabeth M Messmer
    Department of Ophthalmology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Arch Ophthalmol 124:1095-103. 2006
    ..To analyze filtering blebs after trabeculectomy by means of in vivo confocal microscopy and to correlate the images with clinical bleb appearance and function...
  92. ncbi Bacteriologic profile of the conjunctiva in the patients with dry eye
    Yuichi Hori
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Am J Ophthalmol 146:729-34. 2008
    ..To assess the conjunctival bacterial profiles in dry eye and their fluoroquinolone susceptibility patterns...
  93. ncbi Sensations evoked by selective mechanical, chemical, and thermal stimulation of the conjunctiva and cornea
    M C Acosta
    Instituto de Neurociencias, , Campus de San Juan, San Juan de Alicante, Spain
    Invest Ophthalmol Vis Sci 42:2063-7. 2001
    PURPOSE: To study the sensations evoked by selective mechanical, chemical, and thermal stimulation of the conjunctiva and compare them with those elicited by similar stimulation of the cornea...
  94. ncbi Structural and functional outcome of scleral patch graft
    V S Sangwan
    LV Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, India
    Eye (Lond) 21:930-5. 2007
    ..To evaluate the visual and structural outcomes of scleral patch grafting in cases of scleral defect...
  95. pmc Calcium-binding S100 protein expression in pterygium
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Mol Vis 15:335-42. 2009
    ..an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea...
  96. ncbi A new acrylic tissue adhesive for conjunctival surgery: experimental study
    Jorge L Alio
    Ophthalmology Department, Miguel Hernandez University, Alicante, Spain
    Ophthalmic Res 35:306-12. 2003
    ..To evaluate the clinical efficacy and the clinical and histopathologic tolerance of a new acrylic tissue adhesive (ADAL-2) versus 8/0 polyglactin sutures (Vicryl) for its use in conjunctival surgery...
  97. pmc Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration
    C J Jaworski
    Section on Molecular Therapeutics, NEI NIH, Bethesda, MD 20892, USA
    Mol Vis 15:2421-34. 2009
    ....
  98. ncbi Limbal stem cells of the corneal epithelium
    H S Dua
    Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Surv Ophthalmol 44:415-25. 2000
    ..With the latter option, systemic immunosuppression is required. Amniotic membrane transplantation is a useful adjunct to the above procedures in some instances...
  99. pmc Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway
    Xiaofen Zheng
    Department of Ophthalmology, Baylor College of Medicine, Ocular Surface Center, Cullen Eye Institute, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 51:3083-91. 2010
    ..To explore the phenomenon that corneal and conjunctival tissues subjected to desiccating stress (DS) promote Th17 differentiation by stimulating the production of Th17-inducing cytokines through a dendritic cell (DC)-mediated pathway...
  100. ncbi Photokeratitis and other phototoxic effects on the cornea and conjunctiva
    Anthony P Cullen
    School of Optometry and Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Int J Toxicol 21:455-64. 2002
    Except when sleeping, the cornea and interpalpebral conjunctiva are exposed to the ambient environment, both natural and man-made...
  101. ncbi UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells
    Nick Di Girolamo
    Inflammation Research Unit, School of Medical Sciences, Department of Pathology, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 43:3430-7. 2002
    ..The hypothesis tested in the current study is that UV radiation modulates the expression of interleukin (IL)-6 and -8, which could promote the neovascularization and chronic inflammation regularly observed in pterygia...

Research Grants63

  1. Protection of Ocular Tissues During Inflammation
    MELVIN MEDOF; Fiscal Year: 2006
    ..most important finding being that in a rat model the localized blocking of certain regulator activities in the conjunctiva or the anterior chamber can result in massive inflammation as well as frank tissue necrosis...
  2. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The bacterium Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  3. Enzymology of Chlamydia Pathogenesis
    Dewey G McCafferty; Fiscal Year: 2013
    ..Infecting the single columnar layer of epithelial cells of the urogenital tract and conjunctiva, C. trachomatis persists within parasitophorous inclusion vacuoles. During infection, C...
  4. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    Project Summary/Abstract The bacterium Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  5. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..to clinically useful imaging of the cornea, the tear film, and the tissue ultrastructure of the inner eyelid, conjunctiva and sclera...
  6. PROOF OF CONCEPT FOR ANTIMICROBIAL PROPERTIES OF LACRITIN IN VIVO
    John D Sheppard; Fiscal Year: 2010
    ..The lacrimal functional unit is an integrated system comprising the lacrimal glands, ocular surface (cornea, conjunctiva and meibomian glands) and lids, and the sensory and motor nerves that connects them'(2007 International ..
  7. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2013
    ..of HLA Transgenic rabbits in Aim 1 correlates with the presence of effector and memory CD8+ T-cells in the TG, conjunctiva, and/or draining lymph nodes...
  8. Conjunctival Continuous Blood and Tissue Gas Monitor for Infant Care
    LOTHAR KEMPEN; Fiscal Year: 2009
    ..The setup will be based on a thin, flexible, non-irritant fiberoptic probe placed on the conjunctiva of the patient's eye...
  9. Conjunctival Goblet Cell NLRP3 Inflammasome in Ocular Surface Bacterial Infection
    Darlene A Dartt; Fiscal Year: 2013
    ..Corneal response to infection is constrained, but conjunctiva can respond exuberantly...
  10. The Role and Mechanisms of microRNAs in Diabetic Cornea
    Mehrnoosh Saghizadeh; Fiscal Year: 2013
    ..previously found that beside central cornea, diabetes affects limbus, the junctional zone between cornea and conjunctiva housing corneal epithelial stem cells...
  11. Diversity and Dynamic Stability of the Ocular Surface Microbiome
    Russell N Van Gelder; Fiscal Year: 2013
    ..using 454-based pyrosequencing will be used to generate a catalog of bacterial and fungal genera found in the conjunctiva of 100 healthy subjects, diversified for geographic location (from Miami to Seattle), ethnicity, and gender...
  12. Smad3 inhibitors for ophthalmic applications
    Ching Yuan; Fiscal Year: 2010
    ..by alkaline burn, mechanical debridement and trabeculectomy surgery will be conducted on rabbit cornea and conjunctiva for the evaluation of Smad3 inhibitors...
  13. The Role of MAP 3 kinase 1 in Ocular Surface Morphogenesis
    Ying Xia; Fiscal Year: 2012
    ..a common process of transient eyelid closure, resulting in closed eyelids that enclose a mucin-enriched conjunctiva sac protecting corneal maturation and development...
  14. Modulation of conjunctival goblet cell differentiation by immunoregulatory cells
    Cintia Sade de Paiva; Fiscal Year: 2010
    ..that dry eye causes a decrease in the number of CD8+ and 34T intraepithelial lymphocytes (IEL) in the conjunctiva, resulting in decreased levels of immunoregulatory cytokines (e.g...
  15. MUCINS OF THE OCULAR SURFACE
    Ilene K Gipson; Fiscal Year: 2013
    ..Goblet cells, mucin-secreting cells that are intercalated within the stratified epithelium of the conjunctiva disappear in these diseases, as the epithelium becomes keratinized...
  16. Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Darlene A Dartt; Fiscal Year: 2012
    ..We hypothesize that in the inflamed conjunctiva: 1...
  17. The Development Epithelial Sodium Channel Blockers for Chronic Dry Eye
    Benjamin Yerxa; Fiscal Year: 2011
    ..Similar to other epithelial tissues, the epithelium of the conjunctiva and cornea are capable of regulating the hydration status of the mucosal surface through active salt and water ..
  18. The Development Epithelial Sodium Channel Blockers for Chronic Dry Eye
    KARL H DONN; Fiscal Year: 2010
    ..Similar to other epithelial tissues, the epithelium of the conjunctiva and cornea are capable of regulating the hydration status of the mucosal surface through active salt and water ..
  19. Molecular Approaches to Reversing Corneal Goblet Cell Hyperplasia
    Mary Ann Stepp; Fiscal Year: 2013
    ..It has been assumed that goblet cells migrate onto the cornea from the neighboring bulbar conjunctiva. Our data show that the mouse limbus has both conventional stem cell niches and compound niches...
  20. Staph keratitis: mechanism and arrest of ocular damage
    RICHARD JOSEPH O'CALLAGHAN; Fiscal Year: 2012
    ..This organism commonly infects the eyelids and conjunctiva and causes sight-threatening infections of the cornea...
  21. 2010 Biology and Pathobiology of The Cornea
    Shukti Chakravarti; Fiscal Year: 2010
    ..Unlike other barrier tissues of the body, the cornea and supporting adnexa (eyelids, conjunctiva, meibomian glands, lacrimal glands) have evolved distinctive mechanisms to maintain transparency and refraction...
  22. Modeling Novel Treatments for Dry Eye
    GORDON WILLIAM LAURIE; Fiscal Year: 2011
    ..Lacritin is restrictively expressed in lacrimal and meibomian glands and in the cornea and conjunctiva, where it appears to be capable of protecting epithelia of the lacrimal-corneal axis against inflammation-..
  23. Developing Research Capacity in Africa for Studies on HIV-Associated Malignancies
    John A Bartlett; Fiscal Year: 2013
    ..including neoplasms such as cervical cancer, Kaposi's sarcoma, lymphoma and squamous cell carcinoma of the conjunctiva. KCMC and DUMC have highly successful existing collaborations that have received generous NIH support, and ..
  24. Inhibition of VEGF receptor dimerization and signaling in corneal lymphangiogenes
    Jin Hong Chang; Fiscal Year: 2012
    ..normal physiological conditions, the cornea is alymphatic and surrounded by lymphatic vessels residing in the conjunctiva while corneal lymphangiogenic privilege is maintained...
  25. PATHOGENESIS OF CONJUNCTIVAL SQUAMOUS METAPLASIA
    STEPHEN CARL PFLUGFELDER; Fiscal Year: 2013
    ..Interferon gamma increases in the conjunctiva in dry eye...
  26. Metagenomic Analysis of Ocular Surface Microbiome
    Valery I Shestopalov; Fiscal Year: 2010
    ..We will analyze samples of healthy conjunctiva and corneas to examine differences in microbial communities ("microbiome") in different compartments of ocular ..
  27. In Vivo Imaging of Leukocyte-Endothelial Dynamics
    William Mathers; Fiscal Year: 2005
    ..one, we propose to image rolling and sticking of leukocytes in four different normal ocular vascular beds: the conjunctiva, limbus, episclera, and sclera...
  28. Leptospira interrogans Len adhesins
    Brian Stevenson; Fiscal Year: 2009
    ..These bacteria infect humans and other animals by penetrating mucous membranes or conjunctiva, or through breaks in the skin...
  29. Nanosphere-Antibiotic Corneal Contact Lens Delivery System
    CHARLES LEAHY; Fiscal Year: 2009
    ..Such common conditions include active infections of the cornea and conjunctiva, as well as for prevention of pain or potential infection associated with severe dry eye, trauma, or ocular ..
  30. ROLE OF PROSTAGLANDIN, THROMBOXANE AND RELATED AUTACOIDS
    Prasad Kulkarni; Fiscal Year: 1991
    We have thus far determined the capacities of different ocular tissues such as conjunctiva, anterior uvea and cornea of various species (including monkey and human) to synthesize cyclooxygenase products: prostaglandins (PGs) PGE2, ..
  31. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..of the evidence has originally come from studies of skin regeneration, peripheral nerve regeneration and conjunctiva regeneration...
  32. PATHOGENESIS AND EARLY DIAGNOSIS OF EYE INFLAMMATIONS
    Chandler Dawson; Fiscal Year: 1980
    Structural Studies: Studies on surface coats of conjunctiva and cornea and goblet cell structure will be extended to include subhuman primates because findings in these animals will correspond more closely with those in humans...
  33. Structure and Function of Ocular Lacritin
    GORDON LAURIE; Fiscal Year: 2007
    ..Lacritin is also expressed in lacrimal and meibomian glands and in the conjunctiva and is selectively downregulated in blepharitis, the only dry eye disease proteomically examined to date...
  34. DRUG ABSORPTION VIA THE PEPTIDE TRANSPORTER IN THE EYE
    Vincent Lee; Fiscal Year: 2002
    ..in particular and polar drugs in general by targeting dipeptide transport mechanisms in the cornea and conjunctiva. The central hypothesis of the present 3-year proposal is that the corneal and conjunctival epithelial ..
  35. MINIMIZING BLOOD TO EYE RATIO OF TOPICAL EYE MEDICATIONS
    Vincent Lee; Fiscal Year: 1992
    ..to test the hypothesis that, based on the differences in permeability and lipophilicity of the cornea and the conjunctiva, strategies can be developed to minimize systemic absorption while simultaneously promoting the ocular ..
  36. Adenovirus Modulation of Lacrimal Gland Function
    SARAH HAMM ALVAREZ; Fiscal Year: 2005
    Tear proteins play key roles in combating viral and bacterial infections and in supporting cornea and conjunctiva. A primary function of the acinar cells of the lacrimal gland is the production and release of a variety of proteins ..
  37. Transcleral Delivery of Drugs from a Collagen System
    Dale DeVore; Fiscal Year: 2004
    ..of the Phase I project are to formulate collagen-based matrices that can be injected or implanted beneath the conjunctiva and to measure the in vitro human scleral permeability of several drugs including dexamethasone, methotrexate, ..
  38. RETINAL DEGENERATION IN UVEITIS
    Narsing Rao; Fiscal Year: 2002
    ..infiltrating the outer retina rather than in the macrophages infiltrating the uvea, limbal tissue or conjunctiva. Furthermore, the retinal protein arrestin (S-antigen) could induce NOS in macrophages...
  39. Modulation of Adenoviral Infections by CD44
    CRISTHIAN J ILDEFONSO; Fiscal Year: 2010
    ..can be influenced by modulation of the CD44 signaling pathway using Ads of different serotypes to infect human conjunctiva explants and measuring the viral particles released in the presence or absence of HA with Q-PCR...
  40. CHEMICAL SENSORY IRRITATION--CONTRAST WITH OLFACTION
    J Cometto Muniz; Fiscal Year: 1999
    ..Trigeminal chemical sensitivity of the conjunctiva (eye irritation) will also be measured. Stimuli will comprise homologous series of compounds (e.g...
  41. BIOMIMETIC TISSUES--ORAL MUCOSACONJUNCTIVA, AND SKIN
    Jackie Bickenbach; Fiscal Year: 2002
    ..Like the tissues in the oral cavity, the conjunctiva is a mucosal tissue that lines the eye and the eyelids...
  42. WOUND HEALING MODULATION IN GLAUCOMA FILTERING SURGERY
    David Lee; Fiscal Year: 1990
    ..The parameters measured will include intraocular pressure, outflow facility, the appearance of the bleb, conjunctiva, polymer implant, cornea, and anterior chamber...
  43. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
    ..play a crucial role with respect to the nutritional lubricating and anti-inflammatory needs of the cornea and conjunctiva. The Specific Aims are: 1) To determine the complete amino acid sequences of both lipophilin components; define ..
  44. CORNEAL WOUND HEALING AND OPIOID GROWTH FACTOR
    IAN ZAGON; Fiscal Year: 1999
    ..mRNA for OGF hormone (preproenkephalin), zeta receptor, and OGF binding sites in the epithelium, limbus, and conjunctiva of normal cornea...
  45. Femtosecond Laser Enhanced Aqueous Outflow Facility
    Tibor Juhasz; Fiscal Year: 2004
    ..advantages, localized tissue effects, intra-scleral capabilities, highly precise beam delivery through the conjunctiva and sclera, minimally invasive treatments, short procedure times and a potentially decreased healing response ..
  46. ALTERED GENE EXPRESSION IN OCULAR CICATRICIAL PEMPHIGOID
    MELVIN ROAT; Fiscal Year: 1990
    ..connective tissue and activated fibroblasts are observed during histologic and ultrastructural examination of conjunctiva from patients with cicatricial pemphigoid...
  47. Aqueous Vein Drain Tube
    John Swanson; Fiscal Year: 2002
    ..Modern glaucoma surgical techniques are dependent on the formation of a fluid reservoir underneath the conjunctiva called a bleb...
  48. IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATION
    JOHN KRIESEL; Fiscal Year: 2002
    ..are to: 1)Investigate the role of IL-6 in the murine keratitis model by: a) directly injecting IL-6 into the conjunctiva of latently infected mice and b) studying the ability of IL-6 knockout mice to reactivate HSV-1...
  49. HPV IN CONJUNCTIVAL SQUAMOUS DYSPLASIA AND CARCINOMA
    JAN MCDONNELL; Fiscal Year: 1992
    Dysplasia and carcinoma of the conjunctiva comprise a spectrum of atypical proliferations of the conjunctival mucosa. The pathogenesis of these lesions has not been determined...
  50. PTERYGIUM EVALUATION PROJECT
    JOHN TWELKER; Fiscal Year: 2001
    ..that many of his patients suffered from pterygium, a triangular growth of abnormal tissue which grows from the conjunctiva onto the cornea, often causing blurred vision, irritation, and poor cosmesis...
  51. CELL BIOLOGY OF THE OCULAR SURFACE DISEASES
    Y Gordon; Fiscal Year: 1993
    ..During the past 15 years, we have studied the epithelial changes in the conjunctiva and the cornea in these conditions, with particular emphasis on the mitotic rate (elevated) and the goblet cell ..
  52. Noninvasive real-time total hemoglobin measurement utilizing inexpensive liquid c
    ALAN KIVNIK; Fiscal Year: 2007
    ..can pull down the lower eyelid and examine the color of the inside lining of the eyelid, called the palpebral conjunctiva. While a qualitative inspection of the palpebral conjunctiva has been shown to be inaccurate in diagnosing ..
  53. Molecular Regulation Of MAP3 Kinase1 in Ocular Morphogenesis
    ESMOND N GEH; Fiscal Year: 2009
    ..developmental closure in mice results in severe ocular disorders, resembling human congenital diseases, such as conjunctiva-corneal dystrophy, ptosis and microophthalmia...
  54. Analysis of Lacrimal Gland by Laser Microdissection
    John Ubels; Fiscal Year: 2003
    ..The accessory lacrimal glands found in the palpebral and tarsal conjunctiva also produce aqueous tears...
  55. ANTIBODY INDUCTION AND EXPRESSION IN THE EYE
    Paul Montgomery; Fiscal Year: 1999
    ..mucosal inductive site for eliciting tear IgA antibodies following topical antigen administration to the conjunctiva; that a specific lymphocyte receptor mediates the localization of lymphoid populations within lacrimal gland ..
  56. BIOCHEMISTRY OF NORMAL AND DYSTROPHIC CORNEAS IN CULTURE
    Jules Baum; Fiscal Year: 1980
    ..We further hope, with the cornea-conjunctiva skin model, to uncover any underlying systemic metabolic defect associated with each corneal dystrophy and ..
  57. INHIBITION OF OCULAR NEOVASCULARIZATION
    Robert Langer; Fiscal Year: 1992
    ..infused (at a much higher level than with the polymer implant) regionally into mice with B16 melanoma in the conjunctiva and into rabbits carrying V2 carcinoma in the cornea...
  58. FORMULATION FOR IMPROVED OPHTHALMIC ANTIBIOTIC EFFICACY
    S Chandrasekaran; Fiscal Year: 1993
    ..to achieve extended duration of pharmacologically active drug concentrations in the tear film, cornea, and conjunctiva. During this phase of the investigation, a tobramycin formulation (TobraSite) using InSite's proprietary ..
  59. DIABETES MELLITUS AND THE ANTERIOR SEGMENT OF THE EYE
    Richard Schultz; Fiscal Year: 1980
    ..been studied which relate to: diminished corneal sensation; decreased tear production; bacterial flora of the conjunctiva; corneal thickness and endothelial cell density...
  60. VACCINE DEVELOPMENT AND THE IMMUNE RESPONSE TO TRACHOMA
    JUDITH WHITTUM HUDSON; Fiscal Year: 1993
    ..As part of this work, we will study the responsiveness of lymphocytes obtained from the conjunctiva and determine their subset and antigen specificity...
  61. CONTROL OF CYTOKINE RELEASE FROM HUMAN MUCOSAL T CELLS
    James Roche; Fiscal Year: 2001
    ..from applicant's abstract): Evidence suggests that chronic idiopathic inflammation, present in mucosa of human conjunctiva bronchial tree, GU and GI tracts, is often T lymphocyte-mediated...
  62. Hereditary Benign Intraepithelial Dyskeratosis
    Wendi Lambert; Fiscal Year: 2005
    ..is an autosomal dominant cell proliferation disorder characterized by opaque epithelial plaques on the optical conjunctiva and oral mucosa. Plaques appear at birth or in early childhood, recur throughout life, and can obstruct vision...
  63. Ocular Surface Histatins: Synthesis and Function
    Pamela Steele; Fiscal Year: 2003
    ..studies in this laboratory have, for the first time, demonstrated the presence of histatin in the both the conjunctiva and lacrimal gland...