cornea

Summary

Summary: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)

Top Publications

  1. ncbi Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Germany
    Am J Ophthalmol 135:620-7. 2003
  2. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
  3. ncbi Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview
    Gary S L Peh
    Singapore Eye Research Institute, Singapore
    Transplantation 91:811-9. 2011
  4. pmc Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
    H Liang
    Department of Toxicology, Faculty of Biological and Pharmacological Sciences, University Paris Descartes, Paris, France
    Br J Ophthalmol 92:1275-82. 2008
  5. ncbi A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride
    Cuiju Xiong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 49:1850-6. 2008
  6. ncbi MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology
    Jeremy M Sivak
    Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, Center for Vision Research, Tufts University, 750 Washington Street, Box 450, 02111, Boston, MA 02111, USA
    Prog Retin Eye Res 21:1-14. 2002
  7. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
  8. ncbi Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    J Cataract Refract Surg 29:1780-5. 2003
  9. ncbi Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B
    J M Sivak
    Vision Research Laboratories of the New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 222:41-54. 2000
  10. pmc Congenital cataracts and their molecular genetics
    J Fielding Hejtmancik
    MOGS OGVFB NEI NIH, Building 10, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 19:134-49. 2008

Detail Information

Publications358 found, 100 shown here

  1. ncbi Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Germany
    Am J Ophthalmol 135:620-7. 2003
    ..The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt...
  2. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    Corneal avascularity-the absence of blood vessels in the cornea-is required for optical clarity and optimal vision, and has led to the cornea being widely used for validating pro- and anti-angiogenic therapeutic strategies for many ..
  3. ncbi Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview
    Gary S L Peh
    Singapore Eye Research Institute, Singapore
    Transplantation 91:811-9. 2011
    ..A successful combination of tissue-engineered human corneal endothelium coupled with innovative and groundbreaking surgical procedures will bridge basic research involving cultured HCECs, bringing it from bench to bedside...
  4. pmc Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
    H Liang
    Department of Toxicology, Faculty of Biological and Pharmacological Sciences, University Paris Descartes, Paris, France
    Br J Ophthalmol 92:1275-82. 2008
    ..To compare the conjunctival and corneal reactions of commercially available solution of latanoprost (Xalatan) and preservative-free (PF) tafluprost in rabbits...
  5. ncbi A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride
    Cuiju Xiong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 49:1850-6. 2008
    ..To establish a rabbit dry eye model with topical medication of the ocular preparation preservative benzalkonium chloride (BAC)...
  6. ncbi MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology
    Jeremy M Sivak
    Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, Center for Vision Research, Tufts University, 750 Washington Street, Box 450, 02111, Boston, MA 02111, USA
    Prog Retin Eye Res 21:1-14. 2002
    ..For the cornea, we present recent work on the roles of MMPs during various aspects of wound healing...
  7. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
    ..To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival...
  8. ncbi Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    Gregor Wollensak
    Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
    J Cataract Refract Surg 29:1780-5. 2003
    ..To evaluate the biomechanical effect of combined riboflavin-ultraviolet A (UVA) treatment on porcine and human corneas...
  9. ncbi Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B
    J M Sivak
    Vision Research Laboratories of the New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 222:41-54. 2000
    ..we investigated factors required for gelB promoter activity in the developing eye and reepithelializing adult cornea. Pax-6 is a homeobox and paired domain transcription factor that acts at the top of the hierarchy of genes ..
  10. pmc Congenital cataracts and their molecular genetics
    J Fielding Hejtmancik
    MOGS OGVFB NEI NIH, Building 10, Bethesda, MD 20892, USA
    Semin Cell Dev Biol 19:134-49. 2008
    ..The increasing availability of more detailed information about these proteins and their functions and is making it possible to understand the pathophysiology of cataracts and the biology of the lens in general...
  11. ncbi Keratoconus: a review
    Miguel Romero-Jiménez
    MGR Doctores, Madrid, Spain
    Cont Lens Anterior Eye 33:157-66; quiz 205. 2010
    ..This article provides a review on the definition, epidemiology, clinical features, classification, histopathology, aetiology and pathogenesis, and management and treatment strategies for keratoconus...
  12. ncbi In vivo confocal microscopy, an inner vision of the cornea - a major review
    Rudolf F Guthoff
    Department of Ophthalmology, University of Rostock, Rostock, Germany
    Clin Experiment Ophthalmol 37:100-17. 2009
    ..main part of the paper describes the clinical applications emphasizing the anatomy of the normal and pathological cornea, and illustrates side-effects of topical medication, contact lens wear, cross-linking and refractive surgery...
  13. ncbi Determining in vivo biomechanical properties of the cornea with an ocular response analyzer
    David A Luce
    Reichert Inc, Depew, New York, USA
    J Cataract Refract Surg 31:156-62. 2005
    To study the results of an ocular response analyzer (ORA) to determine the biomechanical properties of the cornea and their relationship to intraocular pressure (IOP).
  14. ncbi Collagen-related genes influence the glaucoma risk factor, central corneal thickness
    Eranga N Vithana
    Singapore Eye Research Institute, Singapore
    Hum Mol Genet 20:649-58. 2011
    ..05 × 10⁻⁹). We confirmed the involvement of a previously reported gene for CCT and brittle cornea syndrome (ZNF469) [rs9938149 (p(meta) = 1.63 × 10⁻¹⁶) and rs12447690 (p(meta) = 1.92 × 10⁻¹⁴)]...
  15. pmc Cutting edge: Membrane nanotubes in vivo: a feature of MHC class II+ cells in the mouse cornea
    Holly R Chinnery
    School of Anatomy and Human Biology, University of Western Australia, Crawley Perth, 6009 Western Australia, Australia
    J Immunol 180:5779-83. 2008
    ..Identification of these novel cellular processes in the mammalian cornea provides the first evidence of membrane nanotubes in vivo.
  16. ncbi Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS)
    J D Brandt
    Department of Ophthalmology, University of California-Davis, Sacramento, California, USA
    Ophthalmology 108:1779-88. 2001
    ..The effect of central corneal thickness may influence the accuracy of applanation tonometry in the diagnosis, screening, and management of patients with glaucoma and ocular hypertension...
  17. pmc IL-17 disrupts corneal barrier following desiccating stress
    C S de Paiva
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    Mucosal Immunol 2:243-53. 2009
    ..IL-17R, IL-17A, retinoid-related orphan receptor-gammat, and CC chemokine attractant ligand-20) and IFN-gamma in cornea and conjunctiva...
  18. pmc Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans
    D M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 74:10930-8. 2000
    ..Some clones had cytotoxic-T-lymphocyte activity. The diverse specificities and HLA-restricting alleles of local virus-specific T cells in HSK are consistent with their contribution to HSK by a proinflammatory effect...
  19. ncbi Generation of bioengineered corneas with decellularized xenografts and human keratocytes
    Miguel Gonzalez-Andrades
    Department of Histology, University of Granada, Granada, Spain
    Invest Ophthalmol Vis Sci 52:215-22. 2011
    ..Then, these corneas were recellularized with human keratocytes to obtain a partial human corneal substitute...
  20. ncbi ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue
    Naoki Okumura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Pathol 181:268-77. 2012
    ....
  21. ncbi Assessment of central corneal thickness in normal, keratoconus, and post-laser in situ keratomileusis eyes using Scheimpflug imaging, spectral domain optical coherence tomography, and ultrasound pachymetry
    Dilraj S Grewal
    Grewal Eye Institute, Chandigarh, India
    J Cataract Refract Surg 36:954-64. 2010
    ..To compare the central corneal thickness (CCT) in normal eyes, eyes with keratoconus, and eyes after laser in situ keratomileusis (LASIK) using 3 methods...
  22. pmc Pachymetric mapping with Fourier-domain optical coherence tomography
    Yan Li
    Center for Ophthalmic Optics and Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Cataract Refract Surg 36:826-31. 2010
    ..To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) pachymetric mapping and compare central corneal thickness (CCT) measurements by OCT, ultrasound pachymetry, and scanning-slit tomography...
  23. pmc Polyethylenimine-conjugated gold nanoparticles: Gene transfer potential and low toxicity in the cornea
    Ajay Sharma
    Harry S Truman Memorial Veterans Hospital, Columbia, Missouri, USA
    Nanomedicine 7:505-13. 2011
    ..efficiency and toxicity of 2-kDa polyethylenimine conjugated to gold nanoparticles (PEI2-GNPs) in the human cornea in vitro and rabbit cornea in vivo...
  24. pmc Genetic heterogeneity of lymphangiogenesis in different mouse strains
    Birgit Regenfuss
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Am J Pathol 177:501-10. 2010
    ..Using the mouse cornea micropocket assay (VEGF-C) and the suture-induced corneal neovascularization model in different inbred and wild-..
  25. pmc TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways
    Yan Sun
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 185:4272-83. 2010
    ..aflagellar) strains 19660 and PAO1, we found that F4/80(+) macrophages were the predominant cell type in the cornea expressing TLR2, TLR4, and TLR5...
  26. pmc Role of transforming growth factor Beta in corneal function, biology and pathology
    A Tandon
    Harry S Truman Memorial Veterans Hospital, Columbia, MO 65201, USA
    Curr Mol Med 10:565-78. 2010
    ..cytokine that regulates several essential cellular processes in many parts of the body including the cornea. Three isoforms of TGFbeta are known in mammals and the human cornea expresses all of them...
  27. ncbi Apparent autosomal dominant keratoconus in a large Australian pedigree accounted for by digenic inheritance of two novel loci
    Kathryn P Burdon
    Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, Adelaide, SA, 5042, Australia
    Hum Genet 124:379-86. 2008
    Keratoconus is a debilitating ocular disease characterised by progressive asymmetrical thinning of the cornea, the clear covering at the front of the eye...
  28. pmc Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin
    Lars Bellner
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Exp Eye Res 87:268-78. 2008
    ..the notion that the HO system is critical for controlling the inflammatory and neovascular response in the cornea. Hence, pharmacological amplification of this system may constitute a novel therapeutic strategy for the treatment ..
  29. pmc Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo
    Ajay Sharma
    Harry S Truman Memorial Veterans Hospital, Columbia, MO 65212, USA
    Mol Vis 16:720-8. 2010
    ..RAS components angiotensin converting enzyme (ACE) and angiotensin II receptors (AT(1) and AT(2)) in the rabbit cornea using in vitro and ex vivo models and (ii) the effect of enalapril, an ACE inhibitor, to inhibit angiogenesis in ..
  30. pmc Biomechanics and wound healing in the cornea
    William J Dupps
    The Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, OH 44195, USA
    Exp Eye Res 83:709-20. 2006
    The biomechanical and wound healing properties of the cornea undermine the predictability and stability of refractive surgery and contribute to discrepancies between attempted and achieved visual outcomes after LASIK, surface ablation and ..
  31. ncbi Increased resistance of crosslinked cornea against enzymatic digestion
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum CGC, Fetscherstrasse 74, D 01307 Dresden, Germany
    Curr Eye Res 29:35-40. 2004
    ..Recently, we have started to use the same method for the treatment of corneal ulcers. The aim of the present study was to evaluate the influence of the crosslinking treatment on the resistance of the cornea against enzymatic degradation.
  32. ncbi Decreased density of corneal basal epithelium and subbasal corneal nerve bundle changes in patients with diabetic retinopathy
    Pei Yao Chang
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
    Am J Ophthalmol 142:488-90. 2006
    ..To define alterations in the density of corneal basal epithelium in relation to diabetic retinopathic severity and the alteration of corneal innervation using confocal microscopy...
  33. ncbi Involvement of CTGF in TGF-beta1-stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress
    Qian Garrett
    Wound Healing Research Unit, Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:1109-16. 2004
    ..This study was undertaken to investigate the role of connective tissue growth factor (CTGF) in fibroblast-to-myofibroblast differentiation and fibroblast-mediated collagen matrix contraction in the presence of mechanical stress...
  34. ncbi Corneal wound healing
    Irene C Kuo
    Wilmer Eye Institute, Baltimore, Maryland 21236, USA
    Curr Opin Ophthalmol 15:311-5. 2004
    ..To examine the latest theories in understanding wound healing, primarily as it pertains to refractive surgery but also, briefly, incisional surgery and nonsurgical corneal conditions (iatrogenic injury and noninfectious corneal ulcers)...
  35. ncbi Corneal response to Pseudomonas aeruginosa infection
    Linda Dondero Hazlett
    Department of Anatomy and Cell Biology, Wayne State University, 540 E Canfield, Room 7341, Detroit, MI 48201, USA
    Prog Retin Eye Res 23:1-30. 2004
    ..have been made using a variety of animal models, including inbred murine models that are classed as resistant (cornea heals) vs. susceptible (cornea perforates)...
  36. pmc Control of patterns of corneal innervation by Pax6
    Lucy J Leiper
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Invest Ophthalmol Vis Sci 50:1122-8. 2009
    ..The possibility of a neurotrophic failure in ocular surface disease associated with heterozygosity at the Pax6 locus (aniridia-related keratopathy [ARK]) was investigated...
  37. pmc The molecular basis of corneal transparency
    John R Hassell
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612 4799, USA
    Exp Eye Res 91:326-35. 2010
    The cornea consists primarily of three layers: an outer layer containing an epithelium, a middle stromal layer consisting of a collagen-rich extracellular matrix (ECM) interspersed with keratocytes and an inner layer of endothelial cells...
  38. ncbi Keratoconus
    Y S Rabinowitz
    Cornea Genetic Eye Medical Clinic, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Surv Ophthalmol 42:297-319. 1998
    ..Such studies may provide the clues needed to enable us to better understand the underlying mechanisms that cause the corneal thinning in this disorder...
  39. ncbi The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma
    Mae O Gordon
    OHTS Coordinating Center, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8203, 660 South Euclid, St Louis, MO 63110, USA
    Arch Ophthalmol 120:714-20; discussion 829-30. 2002
    ....
  40. ncbi Safety of UVA-riboflavin cross-linking of the cornea
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
    Cornea 26:385-9. 2007
    ..To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach...
  41. ncbi Crosslinking treatment of progressive keratoconus: new hope
    Gregor Wollensak
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Curr Opin Ophthalmol 17:356-60. 2006
    ..Biomechanical measurements have shown an impressive increase in corneal rigidity of 328.9% in human corneas after crosslinking...
  42. ncbi Central corneal thickness, anterior chamber depth, and pupil diameter measurements using Visante OCT, Orbscan, and Pentacam
    Ahmet Taylan Yazici
    Beyoglu Eye Research and Training Hospital, Istanbul, Turkey
    J Refract Surg 26:127-33. 2010
    ..To evaluate the agreement among three different optical methods in measuring anterior chamber depth (ACD), central corneal thickness (CCT), and pupil diameter...
  43. ncbi Eye evolution: lens and cornea as an upgrade of animal visual system
    Kristyna Jonasova
    Department of Transcriptional Regulation, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
    Semin Cell Dev Biol 19:71-81. 2008
    ..times during evolution since many distinct strategies to enhance light refraction through the use of lens and cornea have been utilized...
  44. ncbi Regression of effect over long-term follow-up of conductive keratoplasty to correct mild to moderate hyperopia
    Jason S Ehrlich
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cataract Refract Surg 35:1591-6. 2009
    ..To evaluate the long-term efficacy and stability of conductive keratoplasty (CK) for low to moderate hyperopia...
  45. ncbi Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy
    Sally Hayes
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, Wales, United Kingdom
    J Cataract Refract Surg 34:657-61. 2008
    ..To evaluate the importance of complete epithelial removal before riboflavin-ultraviolet-A (UVA) corneal collagen crosslinking therapy...
  46. pmc Molecular mechanisms underlying the corneal endothelial pump
    Joseph A Bonanno
    Indiana University, School of Optometry, 800 E Atwater Avenue, Bloomington, IN 47405, USA
    Exp Eye Res 95:2-7. 2012
    The corneal endothelium is responsible for maintaining the hydration of the cornea. This is through a "Pump-Leak" mechanism where the active transport properties of the endothelium represent the "Pump" and the stromal swelling pressure ..
  47. ncbi Iris registration in wavefront-guided LASIK to correct mixed astigmatism
    Mounir Khalifa
    Tanta University Khalifa, Tanta, Egypt
    J Cataract Refract Surg 35:433-7. 2009
    ..To investigate the predictability, safety, and efficiency of wavefront-guided laser in situ keratomileusis (LASIK) with iris-registration technology to correct mixed astigmatism...
  48. ncbi Central and peripheral corneal thickness measured with optical coherence tomography, Scheimpflug imaging, and ultrasound pachymetry in normal, keratoconus-suspect, and post-laser in situ keratomileusis eyes
    Claudia Maria Prospero Ponce
    Tec de Monterrey, School of Medicine, Monterrey, Mexico
    J Cataract Refract Surg 35:1055-62. 2009
    ....
  49. ncbi Anatomy and physiology of the cornea
    Derek W Delmonte
    Department of Ophthalmology, Duke University Eye Center, Duke University Medical Center, Durham, North Carolina, USA
    J Cataract Refract Surg 37:588-98. 2011
    The importance of the cornea to the ocular structure and visual system is often overlooked because of the cornea's unassuming transparent nature...
  50. pmc Ocular herpes simplex virus type 1: is the cornea a reservoir for viral latency or a fast pit stop?
    David P Kennedy
    Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2234, USA
    Cornea 30:251-9. 2011
    ..To present a review supporting and refuting evidence from mouse, rabbit, nonhuman primate, and human studies of herpes simplex virus type 1 (HSV-1) concerning corneal latency...
  51. pmc Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia
    Megan Ulmer
    Duke University Center for Human Genetics, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 53:4468-74. 2012
    ....
  52. pmc Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium
    Rajapandian Sivaganesa Karthikeyan
    Dr G Venkatasamy Eye Research Institute, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    J Infect Dis 204:942-50. 2011
    ..Filamentous fungi of the genera Aspergillus and Fusarium are major causes of corneal ulcers in the United States and in the developing world and result in significant visual impairment and blindness...
  53. pmc Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking
    Yuntao Zhang
    Division of Biology, Kansas State University, Manhattan, Kansas 66506 4901, USA
    J Biol Chem 286:13011-22. 2011
    ..purified, non-glycosylated PG core proteins in solution in vitro has been compared with reactions inside an intact cornea, ex vivo, revealing effects of RFUVA on interactions between PGs and collagen cross-linking...
  54. ncbi 3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea
    Mingtao Zhao
    Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, 136 Hudson Hall, Box 90281, Durham, NC 27705, USA
    Opt Express 18:8923-36. 2010
    Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems for accurate ..
  55. ncbi Corneal changes in diabetes mellitus
    Guzel Bikbova
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana, Chuo Ku, Chiba, Japan
    Curr Diabetes Rev 8:294-302. 2012
    ..keratopathy is a component of diabetic polyneuropathy and is recognized to be the cause of the morbidity of the cornea in diabetic patients...
  56. ncbi Intra-examiner repeatability and agreement of corneal pachymetry map measurement by time-domain and Fourier-domain optical coherence tomography
    Jehn Yu Huang
    Department of Ophthalmology, University of California, San Francisco, Box 0730, 10 Koret Way K325, San Francisco, CA 94143 0730, USA
    Graefes Arch Clin Exp Ophthalmol 248:1647-56. 2010
    ..To assess the intra-examiner repeatability and agreement of corneal pachymetry maps measured by time-domain (Visante OCT) and Fourier-domain optical coherence tomography (RTVue OCT)...
  57. ncbi Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC
    Acta Biomater 8:1068-79. 2012
    ..It is concluded that the cultured RCKs on surfaces coated with HA of different MWs can sense ECM cues, and the multicellular spheroids may potentially be used for corneal stromal tissue engineering applications...
  58. pmc Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels
    Philipp Steven
    Department of Ophthalmology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e26253. 2011
    ..The role of lymphatic vessels in tissue and organ transplantation as well as in tumor growth and metastasis has drawn great attention in recent years...
  59. pmc The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness
    Jac Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Invest Ophthalmol Vis Sci 51:3509-14. 2010
    ..CCT did not correlate genetically with disease and is unlikely to be a useful surrogate endophenotype for POAG...
  60. pmc Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy
    Mitra Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Central Manchester Foundation Trust, Manchester, U K
    Diabetes Care 33:1792-7. 2010
    ..The accurate quantification of human diabetic neuropathy is important to define at-risk patients, anticipate deterioration, and assess new therapies...
  61. ncbi Corneal damage and lacrimal gland dysfunction in a smoking rat model
    Akihiro Higuchi
    Shinanomachi Research Park 6N9, Center for Integrated Medical Research, Keio University School of Medicine, Shinjyuku ku, Tokyo 160 8582, Japan
    Free Radic Biol Med 51:2210-6. 2011
    ..Although the influence of other components in MCS remains unclear, CYPs, especially CYP1A1, probably participate in corneal damage and lacrimal gland dysfunction induced by smoking...
  62. pmc Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands
    Eui Sang Chung
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 175:1984-92. 2009
    ....
  63. pmc Corneal power measurement with Fourier-domain optical coherence tomography
    Maolong Tang
    Center for Ophthalmic Optics and Lasers, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    J Cataract Refract Surg 36:2115-22. 2010
    ..To study the accuracy and repeatability of anterior, posterior, and net corneal power measured by Fourier-domain optical coherence tomography (OCT)...
  64. pmc Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing
    Long Shi
    Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan, People s Republic of China
    PLoS ONE 7:e32128. 2012
    ..the effects of c-Jun N-terminal kinase (JNK) on CTGF expression induce by TGF-β1 in Telomerase-immortalized human cornea stroma fibroblasts (THSF)...
  65. pmc Proliferative capacity of corneal endothelial cells
    Nancy C Joyce
    Schepens Eye Research Institute and Dept of Ophthalmology, 20 Staniford Street, Harvard Medical School, Boston, MA 02114, USA
    Exp Eye Res 95:16-23. 2012
    ..Finally, potential new research directions will be discussed that could take advantage of and/or improve the proliferative capacity of these physiologically important cells in order to develop new treatments to restore corneal clarity...
  66. ncbi Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery
    Rupal Shah
    New Vision Laser Centers, Vadodara, Gujarat, India
    J Cataract Refract Surg 37:127-37. 2011
    ..To report the clinical results of small incision lenticule extraction to correct refractive errors using a femtosecond laser to refine the femtosecond lenticule extraction technique...
  67. ncbi Developmentally regulated expression of hemoglobin subunits in avascular tissues
    Fiona C Mansergh
    Cardiff School of Biosciences, Cardiff University, Wales, UK
    Int J Dev Biol 52:873-86. 2008
    ..These results suggest a paradigm shift: hemoglobin subunits are expressed in the avascular lens and cornea and in pre-hematopoietic embryos...
  68. pmc Effect of down-regulation of aquaporins in human corneal endothelial and epithelial cell lines
    Jwalitha Shankardas
    Department of Biomedical Sciences, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Mol Vis 16:1538-48. 2010
    ....
  69. ncbi Evaluation of the stability of Boston type I keratoprosthesis-donor cornea interface using anterior segment optical coherence tomography
    Julian P S Garcia
    The New York Eye and Ear Infirmary, New York, USA
    Cornea 29:1031-5. 2010
    To evaluate the anatomic stability of an implanted Boston type I keratoprosthesis (KPro)-donor cornea interface and assess the presence or absence of a potential space (gap) between the KPro front plate and donor cornea using anterior ..
  70. pmc Selection of housekeeping genes for use in quantitative reverse transcription PCR assays on the murine cornea
    Shengwei Ren
    Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Mol Vis 16:1076-86. 2010
    To evaluate the suitability of common housekeeping genes (HKGs) for use in quantitative reverse transcription PCR (qRT-PCR) assays of the cornea in various murine disease models.
  71. ncbi Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments
    Sabine Kling
    Instituto de Optica, Daza de Valdés, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Invest Ophthalmol Vis Sci 51:3961-8. 2010
    ..The authors studied the corneal response to variable intraocular pressure (IOP) in porcines eyes after UV collagen cross-linking (CXL), in comparison with untreated eyes...
  72. ncbi Review of ocular immune privilege in the year 2010: modifying the immune privilege of the eye
    Junko Hori
    Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
    Ocul Immunol Inflamm 18:325-33. 2010
    ..Understanding these pathways not only reveals the mechanisms underlying various ocular inflammatory disease conditions, but also has clinical implications for the transplantation field and for the treatment of autoimmunity...
  73. ncbi Anatomy of the human corneal innervation
    Carl F Marfurt
    Indiana University School of Medicine Northwest, 3400 Broadway, Gary, IN 46408, United States
    Exp Eye Res 90:478-92. 2010
    ..of the human corneal innervation using a novel approach involving immunohistochemically stained anterior-cornea whole mounts. Sixteen donor corneas aged 19-78 years were cut with a 6...
  74. ncbi UV absorbance of the human cornea in the 240- to 400-nm range
    Lajos Kolozsvári
    Department of Ophthalmology, Faculty of Medicine, University of Szeged, 6720 Szeged, Korányi fasor 10 11, Hungary
    Invest Ophthalmol Vis Sci 43:2165-8. 2002
    ..To determine the UV absorbance of the corneal layers (epithelium, Bowman layer, stroma) in the 240- to 400-nm range...
  75. ncbi JNK1/2 siRNA inhibits transforming-growth factor-beta1-induced connective tissue growth factor expression and fibrotic function in THSFs
    Yuan Chang
    Department of Ophthalmology, Qilu Hospital of Shandong University, No 107, Wenhua Road West, Lixia District, 250012 Jinan, Shandong, China
    Mol Cell Biochem 335:83-9. 2010
    ..In cornea, however, signaling pathway in the process is unclear...
  76. pmc Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response
    Francesca Seta
    Department of Pharmacology, New York Medical College, Grassland Reservation, Valhalla, NY 10595, USA
    Am J Pathol 169:1612-23. 2006
    ..Thus, HO-2 sets in place a basal tone of anti-inflammatory signals that may be a prerequisite for the ordered execution of an inflammatory and reparative response...
  77. ncbi [A new approach for better comprehension of diseases of the ocular surface]
    C Baudouin
    Centre National d Ophtalmologie des Quinze Vingts, Paris, France
    J Fr Ophtalmol 30:239-46. 2007
    ..will cause local or diffuse hyperosmolarity of the tear film and therefore of superficial epithelial cells of the cornea and/or conjunctiva, stimulating epithelial cells and resident inflammatory cells...
  78. ncbi A murine model of dry eye induced by an intelligently controlled environmental system
    Wei Chen
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Invest Ophthalmol Vis Sci 49:1386-91. 2008
    ..To establish a novel murine model of dry eye using an intelligently controlled environmental system (ICES)...
  79. ncbi The inhibitory effects of bevacizumab eye drops on NGF expression and corneal wound healing in rats
    Eun Chul Kim
    Department of Ophthalmology and Visual Science, Institute of Clinical Medicine Research, College of Medicine, Catholic University of Korea, and Department of Ophthalmology, Seoul St Mary s Hospital, Seoul, Korea
    Invest Ophthalmol Vis Sci 51:4569-73. 2010
    ..To investigate the effect of bevacizumab eye drops on corneal epithelial wound healing in rats...
  80. ncbi Reactive oxygen species (ROS) are essential mediators in epidermal growth factor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing
    Yanan Huo
    Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qinchun Road East, Hangzhou, 310016 Zhejiang, China
    Exp Eye Res 89:876-86. 2009
    EGF is an essential growth factor needed for epithelial cell proliferation and wound healing of the cornea, but the molecular mechanism is not understood...
  81. pmc Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
    Hajime Kubo
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, POB 63, Haartmaninkatu 8, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 99:8868-73. 2002
    ..with lymphatic endothelial markers showed that VEGF-C induces lymphatic as well as blood vessel growth in the cornea. By contrast, VEGF induced angiogenesis but not lymphangiogenesis...
  82. ncbi Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma
    Alberto Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Invest Ophthalmol Vis Sci 50:5251-8. 2009
    The anterior chamber of the eye is a highly specialized structure delimited by the cornea, lens, and iris. It contains the aqueous humor, secreted by the ciliary body and drained by the trabecular meshwork...
  83. ncbi The ocular anomalies in a cystinosis animal model mimic disease pathogenesis
    Vasiliki Kalatzis
    Institut de Genetique Moleculaire de Montpellier, France
    Pediatr Res 62:156-62. 2007
    ..The most dramatic cystine accumulation was seen in the iris, ciliary body, and cornea of Ctns-/- mice. Consistently, Ctns-/- mice had a low intraocular pressure (IOP) and seemed mildly photophobic...
  84. ncbi The mouse cornea micropocket angiogenesis assay
    Michael S Rogers
    The Vascular Biology Program, Children s Hospital Boston, and Department of Ophthalmology, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Nat Protoc 2:2545-50. 2007
    The mouse corneal micropocket angiogenesis assay uses the avascular cornea as a canvas to study angiogenesis in vivo...
  85. pmc Dimensions and morphology of the cornea in three strains of mice
    Johanna Tukler Henriksson
    Texas Eye Research and Technology Center, University of Houston College of Optometry, Houston, TX 77204 2020, USA
    Invest Ophthalmol Vis Sci 50:3648-54. 2009
    To use a histologic approach to obtain dimensional and morphologic information on the cornea in three commonly used strains of mice.
  86. ncbi Cornea-lens transdifferentiation in the anuran, Xenopus tropicalis
    J J Henry
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Dev Genes Evol 211:377-87. 2001
    ..This occurs during larval stages through transdifferentiation of the outer cornea epithelium under control of factors presumably secreted by the neural retina...
  87. ncbi Central corneal thickness and its association with ocular and general parameters in Indians: the Central India Eye and Medical Study
    Vinay Nangia
    Suraj Eye Institute, Nagpur, India
    Ophthalmology 117:705-10. 2010
    ..To evaluate the distribution of central corneal thickness (CCT) and its associations in an adult Indian population...
  88. pmc A novel mutation in GJA8 causing congenital cataract-microcornea syndrome in a Chinese pedigree
    Shanshan Hu
    Department of Ophthalmology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
    Mol Vis 16:1585-92. 2010
    ..To identify the underlying genetic defect in a four-generation family of Chinese origin with autosomal dominant congenital cataract-microcornea syndrome (CCMC)...
  89. pmc Resolvin E1 improves tear production and decreases inflammation in a dry eye mouse model
    Na Li
    Neuroscience Center of Excellence and the Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Ocul Pharmacol Ther 26:431-9. 2010
    ..Here we investigated the role of RvE1 in a DE mouse model...
  90. pmc Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Virol 83:2246-54. 2009
    ..levels of mRNAs for PD-1, CD4, CD8, F4/80, interleukin-4, gamma interferon, granzyme A, and granzyme B in both cornea and TG...
  91. ncbi Advances in Boston keratoprosthesis: enhancing retention and prevention of infection and inflammation
    Bilal F Khan
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, MA 02114, USA
    Int Ophthalmol Clin 47:61-71. 2007
  92. pmc Descemet's stripping automated endothelial keratoplasty outcomes compared with penetrating keratoplasty from the Cornea Donor Study
    Marianne O Price
    Cornea Research Foundation of America, Indianapolis, Indiana 46260, USA
    Ophthalmology 117:438-44. 2010
    To assess outcomes 1 year after Descemet's stripping automated endothelial keratoplasty (DSAEK) in comparison with penetrating keratoplasty (PKP) from the Specular Microscopy Ancillary Study (SMAS) of the Cornea Donor Study.
  93. ncbi Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry
    David Touboul
    Department of Ophthalmology, Bordeaux 2 University, CHU Pellegrin, Place Amelie Raba Leon, Bordeaux, France
    J Cataract Refract Surg 34:616-22. 2008
    ....
  94. ncbi Novel beta-crystallin gene mutations in Chinese families with nuclear cataracts
    Kai jie Wang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China
    Arch Ophthalmol 129:337-43. 2011
    ..To investigate the molecular genetic background in families with nuclear congenital cataract...
  95. pmc Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury
    Joo Youn Oh
    Institute for Regenerative Medicine, Texas A and M Health Science Center College of Medicine at Scott and White, Temple, TX 76502, USA
    Proc Natl Acad Sci U S A 107:16875-80. 2010
    ..We produced a chemical and mechanical injury of the cornea in rats by brief application of 100% ethanol followed by mechanical debridement of corneal and limbal epithelium...
  96. ncbi Gene transfer of interleukin 10 to the murine cornea using electroporation
    Rui Zhou
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Exp Biol Med (Maywood) 232:362-9. 2007
    ..This reduced duration was not due to promoter inhibition by expressed IL-10 or clearance of plasmids from the cornea. However, when DNA nuclear targeting sequences (DTSs) that promote DNA nuclear import were removed from the ..
  97. ncbi Stress wave amplitudes during laser surgery of the cornea
    R R Krueger
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ophthalmology 108:1070-4. 2001
    PURPOSE: To determine the stress wave amplitudes generated during photoablation of the cornea using an argon fluoride excimer laser. DESIGN: Experimental study using porcine eyes...
  98. ncbi IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis
    Sujin Lee
    Department of Microbiology, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Leukoc Biol 71:469-76. 2002
    Topical application of plasmid DNA encoding IL-12 to the cornea of mice prior to ocular infection with Herpes simplex virus type 1 (HSV) results in diminished corneal immunoinflammatory lesions...
  99. ncbi A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents
    Hamid Hosseini
    Ophthalmology Department, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Med Hypotheses 68:799-801. 2007
    ..Further investigations are needed to place these medical treatments alongside corneal neovascularization therapeutics...
  100. ncbi Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts
    Ying Lu
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 47:3796-800. 2006
    ..The effects of triptolide on the expression of these proteins induced by lipopolysaccharide (LPS) in human corneal fibroblasts were examined in comparison with those of dexamethasone...
  101. ncbi Mechanisms of rubbing-related corneal trauma in keratoconus
    Charles W McMonnies
    From the School of Optometry and Vision Science, University of New South Wales, Kensington, Australia
    Cornea 28:607-15. 2009
    ..Corneal scarring in keratoconus, which is observed prior to contact lens wear and in association with a chronic habit of abnormal rubbing, suggests a keratocyte change to a repair phenotype in response to rubbing trauma...

Research Grants70

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo
  3. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..e., trigeminal ganglion) or cornea, both resident and bone marrow-derived cells with a functional type I IFN pathway are required to maximize ..
  4. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
    ..of this gene family, is highly expressed in epithelial cells, including epithelial cells of the limbal and central cornea. To investigate the role of Clims, we generated transgenic mice expressing a dominant-negative Clim molecule (DN-..
  5. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Herpes Simplex Virus -1 (HSV-1) primary and recurrent infection may result in scarring of the cornea and is the leading cause of blindness in US and the developed world...
  6. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ....
  7. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
    ..cause of morbidity and can result in blindness, and most common manifestations of ocular infections affect the cornea, resulting in keratitis. Fungal keratitis is predominantly caused by filamentous fungi Fusarium, but yeasts (e.g...
  8. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cornea serves as a barrier for the eye and its transparency is required for its function to refract and transmit light to the retina. The normal cornea is avascular...
  9. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..and trainees matches the goals in NEI's long-standing plan for eye and vision research for retinal diseases, cornea, and lens and cataract programs, as well as the strabismus, amblyopia and visual processing...
  10. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2012
    ..S. alone, several million patients have undergone LASIK. LASIK manipulations of the cornea create a transparent, but permanently non-attached stromal flap...
  11. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..The ability of the differentiated MSCs to maintain a clear cornea will be followed in vivo over an 8-week period by scoring for corneal opacity and vessel in-growth...
  12. MOLECULAR REGULATION OF CORNEAL WOUND HEALING
    Fu Shin X Yu; Fiscal Year: 2013
    ..While in normal cornea an epithelial wound is usually healed in a timely fashion without any complications, epithelial wound healing is ..
  13. Cytoskeletal Keratins in Epithelial Immunity to Bacterial Keratitis
    K P CONNIE TAM; Fiscal Year: 2013
    ..and activity of KDAMPs, that KDAMPs kill bacteria by lysing bacterial membranes, and that KDAMPs protect the cornea against bacterial adherence. This will be tested in three aims...
  14. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..strongly indicate that connective tissue growth factor (CTGF) is the dominant scar-inducing growth factor in the cornea and in other tissues, including skin and kidney...
  15. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..5 million Americans each year. Tissue-targeted and localized gene therapy for the cornea offers promise to cure, reduce and/or prevent corneal blindness caused by trauma, injury, infection or inherited ..
  16. Pathogensis of Bacterial corneal infection
    Gerald B Pier; Fiscal Year: 2013
    ..the host to have an adequate and helpful inflammatory response to clear pathogens without causing damage to the cornea. For P...
  17. Mechanisms of flagellin-induced protection against microbial keratitis
    Fu Shin X Yu; Fiscal Year: 2013
    Microbial keratitis is a common cause of vision loss. The cornea is exquisitely sensitive to inflammation- mediated damage and therefore has strong innate defenses...
  18. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..discomfort and a lower chance of infection, a dose-response effect, and the ability to treat the peripheral cornea. This project is designed to lay groundwork for rapid translation of this technology into a treatment...
  19. The role of plasmacytoid dendritic cells in corneal immunity
    Pedram Hamrah; Fiscal Year: 2013
    ..In preliminary studies, we have discovered a novel population of resident pDC in the cornea. In vivo pDC depletion in our preliminary studies demonstrate that pDC are the major source of IFN-a in the cornea ..
  20. The Role of Galectins in Corneal Hem- and Lymphangiogenesis
    Noorjahan Panjwani; Fiscal Year: 2013
    ..The presence of BV and LV essentially abrogates the immune privilege status of the cornea. The goal of this project is to understand the molecular mechanisms that regulate hemangiogenesis (HA) and ..
  21. CAP37 and ocular inflammation
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..in response to infection, suggests that it could play a key role in regulating inflammation and healing in the cornea and in the long term form the basis for developing new therapeutics for certain eye infections...
  22. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2011
    ..Using pre-established corneal cDNA libraries, cornea-specific transcription variants by the capsite hunting method (for variants in the 5-UTR), rapid amplification of ..
  23. CYTOTOXIC LYMPHOCYTES AND HSV-1 CORNEAL LESIONS
    Robert L Hendricks; Fiscal Year: 2013
    ..of herpes simplex virus type 1 (HSV-1) from a latent state in sensory neurons and anterograde transport to the cornea appears to be a predominant cause of recurrent herpes keratitis, a blinding disease of the cornea...
  24. Development Of An Eye Drop To Treat Presbyopia
    William H Garner; Fiscal Year: 2012
    ..our co-drug to achieve therapeutic levels of active agent in the rabbit aqueous humor without adversely affecting cornea health and lens metabolism...
  25. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..of this proposal is to develop an imaging handpiece that is more suited to clinically useful imaging of the cornea, the tear film, and the tissue ultrastructure of the inner eyelid, conjunctiva and sclera...
  26. CORNEAL LIPID METABOLISM AND RESPONSE TO INFLAMMATION
    Haydee E P Bazan; Fiscal Year: 2010
    ..II] PAF promotes neovascularization in inflamed cornea by inducing upregulation of vascular endothelial growth factor (VEGF) and down-regulation of thrombospondin-1 (TSP-..
  27. Genetic Basis of Nanophthalmos and Human Ocular Biometry
    Olof H Sundin; Fiscal Year: 2010
    ..Extreme hyperopia, from +8 to +25 diopters, occurs because the image-forming cornea and lens are too close to the retina...
  28. Integrating cell sorting and tissue shaping mechanisms during cornea maturation
    Philip M Iannaccone; Fiscal Year: 2010
    ..We are developing a concurrent model of vertebrate cornea maturation using a combination of experiment, imaging and computation...
  29. Novel virulence and exoenzyme regulators
    ROBERT M SHANKS; Fiscal Year: 2013
    ..This study is designed to determine how S. marcescens is able to successfully infect and damage the cornea. Specifically, we will evaluate the role of secreted proteases, a pore-forming hemolysin, and a newly discovered ..
  30. Corneal Lymphatics &Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2013
    Neovascularization in the normally avascular cornea can lead to a compromised visual axis...
  31. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2011
    ..Pilot study of application of this imaging system for diagnosis of cornea disease will be performed too...
  32. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2012
    ..Pilot study of application of this imaging system for diagnosis of cornea disease will be performed too...
  33. Sensimmer Virtual Phaco Trainer for Cataract Surgery
    P Pat Banerjee; Fiscal Year: 2011
    ..as measured by total tip path length, and appropriate use of phaco power settings to avoid thermal damage to the cornea. PUBLIC HEALTH RELEVANCE: ImmersiveTouch-Sensimmer, Inc...
  34. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    ..HSK is a chronic, immuno-inflammatory disease of the cornea caused by HSV-1, and current anti-viral and anti-inflammatory therapies fail in approximately 30% of patients, ..
  35. Regulation of Eye Growth and Development by the Lens
    William R Jeffery; Fiscal Year: 2012
    ..The lens is also important in protecting the retina from apoptotic cell death and in the normal development of the cornea and sclera...
  36. PROOF OF CONCEPT FOR ANTIMICROBIAL PROPERTIES OF LACRITIN IN VIVO
    John D Sheppard; Fiscal Year: 2010
    ..The lacrimal functional unit is an integrated system comprising the lacrimal glands, ocular surface (cornea, conjunctiva and meibomian glands) and lids, and the sensory and motor nerves that connects them'(2007 ..
  37. Genomic systems approach to measure HSV-1-specific T-cell dominance in humans
    David M Koelle; Fiscal Year: 2013
    ..CD8 T-cells are a critical component of the immune response to HSV-1 and localize to infected skin, cornea, retina, and trigeminal ganglia...
  38. Sex, sex steroids and dry eye syndromes
    David A Sullivan; Fiscal Year: 2013
    ..film dysfunction, in turn, may severely impact the eye and lead to desiccation, ulceration and perforation of the cornea, an increased incidence of infectious disease, and pronounced visual impairment and blindness...
  39. Sex-specific Regulation of Acute Inflammation and Resolution
    Karsten Gronert; Fiscal Year: 2013
    ..The cornea highly expresses a key enzyme for LXA4 formation, 15-lipoxygenase (15-LOX), and its G-protein coupled receptor ALX...
  40. Corneal Stromal-Epithelial Interactions During Fibrosis and Regeneration
    James D Zieske; Fiscal Year: 2012
    ..In the cornea, severe wounds that damage the basement membrane heal using fibrosis...
  41. Herpes Simplex Virus Egress from Cells and Spread into Neuronal Axons
    David C Johnson; Fiscal Year: 2013
    ..While many HSV infections are relatively benign, HSV infections of the cornea can have serious consequences...
  42. Corneal Expression and Function of Slurp1
    SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2013
    ..activator receptor (uPAR) related protein-1 (Slurp1) is one of the most abundantly expressed proteins in the cornea and is secreted into the tear film, its biological function in the ocular surface is unknown...
  43. Identification, Characterization and Enrichment of Adult Urothelial Stem Cells
    ERIC ABRAHAM KURZROCK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Self-renewing epithelial tissues in skin, cornea, intestine and prostate have been shown to contain stem cells that provide the tissue's regenerative potential...
  44. Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 Entry
    Vaibhav Tiwari; Fiscal Year: 2011
    ..Our recent observation further indicates that cornea of ZF embryo infected with HSV-1 leads to extensive dendrite formation followed by cell damage which mimics the ..
  45. Engineering of Human Corneal Endothelial Grafts
    Ying Ting Zhu; Fiscal Year: 2012
    ..to restore vision in eyes inflicted with bullous keratopathy relies upon transplantation of a cadaver donor cornea containing a healthy corneal endothelium...
  46. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2013
    Herpes simplex virus 1 (HSV-1) infects the cornea and then establishes latency in sensory neurons of the trigeminal ganglia (TG)...
  47. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2013
    Abstract: Acanthamoeba keratitis (AK) is a serious, debilitating, and intensely painful infection of the cornea caused by parasites of the genus Acanthamoeba...
  48. Corneal endothelial cell survival in human donor corneas for transplantation
    Shay Whey M Koh; Fiscal Year: 2012
    ..state of the corneal endothelium, including CE cell size, shape, and retention, in situ in the human donor cornea, whereas exogenous VIP protects it against the killing effect of oxidative stress...
  49. Development of a novel connexin-based peptide for the treatment of corneal injury
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2012
    ..ACT1 peptide has been shown to promote corneal wound closure following ethanol burn injuries to the rat cornea, compared with that of a control peptide...
  50. HAIR FOLLICLE BULGE CELLS IN TUMORIGENESIS AND ALOPECIA
    George Cotsarelis; Fiscal Year: 2009
    ..stem cells are responsible for the regeneration of self-renewing tissues such as epidermis, hair follicle, and cornea. We originally identified putative epithelial stem cells in the bulge of the hair follicle...
  51. Functions of mammalian PGLYRPs in the cornea
    Shukti Chakravarti; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The cornea is a transparent, refractive, protective mucosal barrier of the eye. Corneal infections pose a serious threat to healthy vision...
  52. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2013
    ..an eyeblink reflex in response to a tone can be learned when the tone is repeatedly paired with an airpuff to the cornea. We have developed an in vitro model of vertebrate associative learning using a turtle brain stem preparation that ..
  53. The Role and Mechanisms of microRNAs in Diabetic Cornea
    Mehrnoosh Saghizadeh; Fiscal Year: 2013
    ..We have previously found that beside central cornea, diabetes affects limbus, the junctional zone between cornea and conjunctiva housing corneal epithelial stem cells...
  54. Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal Diseases
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..S. troops injured in recent wars highlight the incompetence of current therapy. The cornea is an ideal organ for gene therapy because of its accessibility and immune-privilege status...
  55. Zebrafish Model of Human Corneal Development and Disease
    Martin Heur; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Abstract: The cornea is the transparent, anterior most ocular tissue that provides most of the refractive power of the eye...
  56. Role of unfolded protein response and COL8A2 in Fuchs corneal dystrophy
    Albert S Jun; Fiscal Year: 2013
    ..FECD results from chronic loss of corneal endothelial cells which line the inner surface of the cornea and maintain physiologic hydration necessary for corneal clarity...
  57. The Role of IL-17 in fungal keratitis
    PATRICIA RENEE TAYLOR; Fiscal Year: 2013
    ..the current study, we examined the role of IL-17 in a murine model of Aspergillus and Fusarium infections of the cornea, which are a major cause of blindness and visual impairment worldwide...
  58. Role of primary cilia in corneal development and repair
    Carlo Iomini; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Transparency, structural integrity and barrier function of the cornea depends on its complex, layered organization and the function of the cells that populate it...
  59. Smad3 inhibitors for ophthalmic applications
    Ching Yuan; Fiscal Year: 2010
    ..neovascularization by alkaline burn, mechanical debridement and trabeculectomy surgery will be conducted on rabbit cornea and conjunctiva for the evaluation of Smad3 inhibitors...
  60. Regulation of Ocular Neural Crest and its Implications in Congenital Eye Diseases
    BRENDA LYNN BOHNSACK; Fiscal Year: 2013
    ..Malformations of the cornea, iris, and iridocorneal angle result from anterior segment dysgenesis and include Axenfeld-Rieger Syndrome (ARS) ..
  61. Lipid Rafts in Adenoviral Ocular Pathogenesis
    Jaya Rajaiya; Fiscal Year: 2013
    ..this proposal is to elucidate how lipid rafts and caveosomes in corneal cells influence entry and trafficking of cornea tropic HAdV-D...
  62. Planning Grant for Parasitic Ulcer Treatment Trial
    Jeremy David Keenan; Fiscal Year: 2013
    ..The use of topical corticosteroids for acanthamoeba keratitis is controversial. Some cornea specialists oppose the use of corticosteroids, since they have been shown to promote acanthamoeba proliferation...
  63. Ocular Lymphangiogenesis
    DANIEL J CARR; Fiscal Year: 2010
    ..Neovascularization and lymphangiogenesis are undesirable events that often transpire in the normally avascular cornea as a result of inflammation...
  64. Artificial Cornea Using New Biomaterials
    MAX MAGINNESS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Artificial Cornea Using New Biomaterials PD/PI Maxwell Maginness PhD Project Summary/Abstract...
  65. Novel Corneal Implant Materials
    Shiao Chang; Fiscal Year: 2006
    ..DO NOT EXCEED THE SPACE PROVIDED. Surgical methods to treat refractive error by remodeling the cornea, such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK), are common in the U.S...
  66. Expressions of Specialized Collagens in the Cornea
    Marion K Gordon; Fiscal Year: 2010
    The cornea uses extracellular matrix (ECM) molecules, in particular, collagens, to set up an architecture that serves two crucial functions: refraction and transmission of light...
  67. To demonstrate the feasibility of a home tonometer to monitor IOP without contact
    JIM SON CHOU; Fiscal Year: 2010
    ..The system will provide the relevant cornea anatomical parameters and one of the aims of this research is to create an algorithm enable the derivation of an ..
  68. Novel Treatment for Post-LASIK Ectasia
    MATTHEW MATTSON; Fiscal Year: 2009
    ..S., 1 in 2500 will result in post-LASIK ectasia-a thinning and bulging of the cornea analogous to keratoconus that becomes evident months or years after the LASIK procedure...
  69. LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS
    Michael Berns; Fiscal Year: 2002
    ..Human dermal microvascular endothelial cells (MEC); and (2) tumor-induced capillary proliferation in the rabbit cornea. The specific aims of the clinical studies are to determine the efficacy of PDT in Carcinoma In Situ (CIN) in the ..
  70. EXCIMER LASER ABLATION TO CORRECT REFRACTIVE ERROR
    MARGUERITE MC DONALD; Fiscal Year: 1991
    ..energy of the excimer laser is capable of excising or removing human tissue, such as the anterior layers of the cornea. The cornea provides more than 80% of the refractive power of the eye, and small changes in the shape of the ..