- The Rx homeobox gene is essential for vertebrate eye development
P H Mathers
Laboratory of Developmental Biology, Food and Drug Administration, Rockville, Maryland 20852, USA
Nature 387:603-7. 1997
Development of the vertebrate eye requires a series of steps including specification of the anterior neural plate, evagination of the optic vesicles from the ventral forebrain, and the cellular differentiation of the lens and retina...
- Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
A H Brand
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
Development 118:401-15. 1993
..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway.
- LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
Cell 107:513-23. 2001
..These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass...
- Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration
Sylvain W Lapan
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell Rep 2:294-307. 2012
Among the millions of invertebrate species with visual systems, the genetic basis of eye development and function is well understood only in Drosophila melanogaster...
- Eye contact detection in humans from birth
Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom
Proc Natl Acad Sci U S A 99:9602-5. 2002
Making eye contact is the most powerful mode of establishing a communicative link between humans. During their first year of life, infants learn rapidly that the looking behaviors of others conveys significant information...
- salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown 02129, USA
Cell 110:467-78. 2002
..The human ortholog of salvador (hWW45) is mutated in three cancer cell lines. Thus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis...
- The impact of ocular blood flow in glaucoma
University Eye Clinic, Basel, Switzerland
Prog Retin Eye Res 21:359-93. 2002
..This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP...
- Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Cell 87:651-60. 1996
The Drosophila eye has contributed much to our knowledge of cell differentiation...
- Stages of normal development in the medaka Oryzias latipes
Department of Biology, Aichi University of Education, 16 Terayamashita, Igaya cho, Kariya City, Aichi 448 0001, Japan
Mech Dev 121:605-18. 2004
..After hatching, development of the larvae (fry) and young can be divided into six stages based on such diagnostic features as the fins, scales and secondary sexual characteristics...
- Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish
Department of Biology, University of Maryland, College Park, MD 20742, USA
BMC Biol 10:108. 2012
..More recently, several different adaptive hypotheses have been proposed to explain eye degeneration based on studies in the teleost Astyanax mexicanus, which consists of blind cave-dwelling (cavefish) ..
- The role of Pax-6 in eye and nasal development
J C Grindley
Developmental Genetics Section, Western General Hospital, Edinburgh, UK
Development 121:1433-42. 1995
Small eye (Sey) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities...
- Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models
Department of Ocular Pharmacology and Pharmacy, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India
BMC Complement Altern Med 13:1. 2013
The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies...
- Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
Developmental Biology Department, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Science 306:869-71. 2004
..Comparative analysis indicates that both types of photoreceptors, with distinct opsins, coexisted in Urbilateria, the last common ancestor of insects and vertebrates, and sheds new light on vertebrate eye evolution.
- Regressive evolution in the Mexican cave tetra, Astyanax mexicanus
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Curr Biol 17:452-4. 2007
..and pigmentation in cave-adapted animals are unknown; Darwin famously questioned the role of natural selection in eye loss in cave fishes: "As it is difficult to imagine that eyes, although useless, could be in any way injurious ..
- Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
Invest Ophthalmol Vis Sci 45:4293-301. 2004
To evaluate whether experimentally induced dry eye in mice activates mitogen-activated protein kinase (MAPK) signaling pathways, c-Jun N-terminal kinases (JNK), extracellular-regulated kinases (ERK), and p38 and stimulates ocular surface ..
- Eye morphogenesis and patterning of the optic vesicle
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
Curr Top Dev Biol 93:61-84. 2010
Organogenesis of the eye is a multistep process that starts with the formation of optic vesicles followed by invagination of the distal domain of the vesicles and the overlying lens placode resulting in morphogenesis of the optic cup...
- Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
Brian S Robinson
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Curr Biol 20:582-90. 2010
- Design principles of insect and vertebrate visual systems
Joshua R Sanes
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Neuron 66:15-36. 2010
- Eye development
Helmholtz Center Munich German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
Curr Top Dev Biol 90:343-86. 2010
The vertebrate eye comprises tissues from different embryonic origins: the lens and the cornea are derived from the surface ectoderm, but the retina and the epithelial layers of the iris and ciliary body are from the anterior neural ..
- Hedgehog signalling controls eye degeneration in blind cavefish
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Nature 431:844-7. 2004
..Here we show that hh gene expression at the embryonic midline controls eye degeneration in blind cavefish...
- Melanopsin: An opsin in melanophores, brain, and eye
Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Proc Natl Acad Sci U S A 95:340-5. 1998
..Its expression in retinal and nonretinal tissues suggests a role in vision and nonvisual photoreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and photoperiodic physiology...
- Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Proc Natl Acad Sci U S A 107:21034-9. 2010
Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development. Four Pax-6 isoforms have been reported previously...
- miRNeye: a microRNA expression atlas of the mouse eye
Telethon Institute for Genetics and Medicine, Via P Castellino 111, Naples, Italy
BMC Genomics 11:715. 2010
MicroRNAs (miRNAs) are key regulators of biological processes. To define miRNA function in the eye, it is essential to determine a high-resolution profile of their spatial and temporal distribution.
- Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development
Division of Endocrinology, Diabetes and Hypertension, Departments of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cell 151:1200-13. 2012
..Here, we report that Xenopus Tet3 plays an essential role in early eye and neural development by directly regulating a set of key developmental genes...
- Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Development 135:1169-78. 2008
During vertebrate eye development, the transcription factor MITF plays central roles in neuroepithelial domain specification and differentiation of the retinal pigment epithelium...
- Eyes always attract attention but gaze orienting is task-dependent: evidence from eye movement monitoring
Roxane J Itier
The Rotman Research Institute, Baycrest, Toronto, Canada
Neuropsychologia 45:1019-28. 2007
..Here, the shift in attention towards the eye region and gaze direction of a perceived face was studied in two tasks by monitoring eye movements...
- Does it make a difference if I have an eye contact with you or with your picture? An ERP study
Laura M Pönkänen
Department of Psychology, FIN 33014, University of Tampere, Finland
Soc Cogn Affect Neurosci 6:486-94. 2011
Several recent studies have begun to examine the neurocognitive mechanisms involved in perceiving and responding to eye contact, a salient social signal of interest and readiness for interaction...
- Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range
Institute of Physics, Nicolaus Copernicus University, ul Grudziadzka 5 7, PL 87 100 Torun, Poland
Opt Express 17:14880-94. 2009
We present an application of in vivo anterior segment imaging of the human eye with an ultrahigh speed swept source OCT instrument. For this purpose, a dedicated OCT system was designed and constructed...
- Pax-6, a murine paired box gene, is expressed in the developing CNS
Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Germany
Development 113:1435-49. 1991
..5 of development. Pax-6 is also expressed in the developing eye, the pituitary and the nasal epithelium.
- Gene flow and population structure in the Mexican blind cavefish complex (Astyanax mexicanus)
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Oeiras, 2780 157, Portugal
BMC Evol Biol 12:9. 2012
- Emotion recognition in children with autism spectrum disorders: relations to eye gaze and autonomic state
Department of Psychiatry MC 912, Brain Body Center, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL, 60612, USA
J Autism Dev Disord 40:358-70. 2010
..Within the ASD group, children with higher amplitude RSA recognized emotions faster. Less severe ASD symptoms and increased gaze to the eye region in children with ASD were related to more accurate emotion recognition.
- Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
Biozentrum, University of Basel, Switzerland
Science 267:1788-92. 1995
..It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans...
- Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
H Wayne Peng
Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Genes Dev 23:2307-19. 2009
..Tsh), two DNA-binding transcription factors expressed in the uncommitted progenitor cells of the Drosophila eye imaginal disc...
- A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
R S Stowers
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
Genetics 152:1631-9. 1999
..called EGUF/hid) that uses both the GAL4/UAS and FLP/FRT systems to overcome this limitation for the Drosophila eye by producing genetically mosaic flies that are otherwise heterozygous but in which the eye is composed exclusively ..
- Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations
Sophie I Candille
Department of Genetics, Stanford University, Stanford, California, United States of America
PLoS ONE 7:e48294. 2012
..But skin, hair, and eye pigmentation vary continuously...
- Neurogenic potential of stem/progenitor-like cells in the adult mammalian eye
Stefanie G Wohl
Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany
Prog Retin Eye Res 31:213-42. 2012
..Herein, we particularly feature the adult rodent eye and provide an overview of all putative neuronal progenitor-like cells attributed to the various ocular areas that ..
- Eye evolution and its functional basis
Dan E Nilsson
Department of Biology, Lund Vision Group, Lund University, Lund, Sweden
Vis Neurosci 30:5-20. 2013
b>Eye evolution is driven by the evolution of visually guided behavior. Accumulation of gradually more demanding behaviors have continuously increased the performance requirements on the photoreceptor organs...
- Restoring eye size in Astyanax mexicanus blind cavefish embryos through modulation of the Shh and Fgf8 forebrain organising centres
Equipe Développement Evolution du Cerveau Antérieur, UPR3294 NED, CNRS, Institut Alfred Fessard, 91198 Gif sur Yvette, France
Development 138:2467-76. 2011
The cavefish morph of the Mexican tetra (Astyanax mexicanus) is blind at adult stage, although an eye that includes a retina and a lens develops during embryogenesis. There are, however, two major defects in cavefish eye development...
- Exaggerated eye growth in IRBP-deficient mice in early development
Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA
Invest Ophthalmol Vis Sci 52:5804-11. 2011
Because interphotoreceptor retinoid-binding protein (IRBP) is expressed before being needed in its presumptive role in the visual cycle, we tested whether it controls eye growth during development.
- A look at autoimmunity and inflammation in the eye
Rachel R Caspi
Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 120:3073-83. 2010
- scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
Anthony M Brumby
Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
EMBO J 22:5769-79. 2003
..We show that scribble mutant clones in the eye disc exhibit ectopic expression of cyclin E and ectopic cell cycles, but do not overgrow due to increased cell ..
- Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis
Vaibhav P Pai
Department of Biology and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155, USA
Development 139:313-23. 2012
Uncovering the molecular mechanisms of eye development is crucial for understanding the embryonic morphogenesis of complex structures, as well as for the establishment of novel biomedical approaches to address birth defects and injuries ..
- Early eye development in vertebrates
R L Chow
Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Annu Rev Cell Dev Biol 17:255-96. 2001
..a synthesis that combines data from classical experimentation and recent advances in our understanding of early eye development. Emphasis is placed on the events that underlie and direct neural retina formation and lens induction...
- Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
Development 121:4045-55. 1995
..gene is known to play an essential role in controlling the initial events of pattern formation in the eye disc and is also required for the development of other parts of the fly visual system including the optic lobes...
- Rapid evolutionary rewiring of a structurally constrained eye enhancer
Christina I Swanson
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Curr Biol 21:1186-96. 2011
..Here, we examine evolutionary changes to the sequence and structure of sparkling, a Notch/EGFR/Runx-regulated enhancer that activates the dPax2 gene in cone cells of the developing Drosophila eye.
- The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
J Immunol 188:1742-50. 2012
Immune privilege is used by the eye, brain, reproductive organs, and gut to preserve structural and functional integrity in the face of inflammation...
- The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development
Jón H Hallsson
Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
Genetics 167:233-41. 2004
..for the development of several different cell types, including the retinal pigment epithelial (RPE) cells of the eye. In Mitf mutant mice, the presumptive RPE cells hyperproliferate, abnormally express the retinal transcriptional ..
- Mutations Modulating Raf signaling in Drosophila eye development
B J Dickson
Zoologisches Institut, Universitat Zurich, Switzerland
Genetics 142:163-71. 1996
The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase...
- Dorsal premotor neurons encode the relative position of the hand, eye, and goal during reach planning
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Neuron 51:125-34. 2006
..intraparietal area (area MIP) of two monkeys while systematically varying the starting position of the hand and eye during reaching. PMd neurons encoded the relative position of the target, hand, and eye...
- Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
J M Warrick
Department of Biology, University of Pennsylvania and University of Pennsylvania Medical School, Philadelphia 19104, USA
Cell 93:939-49. 1998
..Our results demonstrate that cellular mechanisms of human glutamine-repeat disease are conserved in invertebrates. This fly model will aid in identifying additional factors that modulate neurodegeneration...
- Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Am J Hum Genet 82:304-19. 2008
..Our finding of low-penetrant variants in BMP4 and HH signaling partners is suggestive of an interaction between the two pathways in humans...
- Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuron 55:556-64. 2007
..These findings support the disease mechanism of FXTAS of rCGG repeat sequestration of specific RBPs, leading to neuronal cell death, and implicate that Pur alpha plays an important role in the pathogenesis of FXTAS...
- Cyclosporine A delivery to the eye: a pharmaceutical challenge
School of Pharmacy, University of Geneva, Geneva, Switzerland
Eur J Pharm Biopharm 56:307-18. 2003
..of local ophthalmic conditions involving cytokines, such as corneal graft rejection, autoimmune uveitis and dry eye syndrome. Local administration is expected to avoid the various side effects associated with systemic delivery...
- Individual cell migration serves as the driving force for optic vesicle evagination
Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Science 313:1130-4. 2006
The cellular mechanisms underlying organ formation are largely unknown. We visualized early vertebrate eye morphogenesis at single-cell resolution by in vivo imaging in medaka (Oryzias latipes)...
- Regressive evolution in Astyanax cavefish
William R Jeffery
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Annu Rev Genet 43:25-47. 2009
- Neural bases of eye and gaze processing: the core of social cognition
Roxane J Itier
Psychology Department, University of Waterloo, Ontario, Canada
Neurosci Biobehav Rev 33:843-63. 2009
..attention and intentions of others could be linked to difficulties in extracting the relevant information from the eye region including gaze direction. In this review, we address the central role of eyes and gaze in social cognition...
- Intersubject variability of foveal cone photoreceptor density in relation to eye length
Kaccie Y Li
School of Optometry, University of California, Berkeley, CA 94720 2020, USA
Invest Ophthalmol Vis Sci 51:6858-67. 2010
..The intersubject variability of foveal cone density was measured and its relation to eye length evaluated.
- The arrangement of the three cone classes in the living human eye
Center for Visual Science, University of Rochester, New York 14627, USA
Nature 397:520-2. 1999
..Adaptive optics, a technique used to overcome blur in ground-based telescopes, can also overcome blur in the eye, allowing the sharpest images ever taken of the living retina...
- Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Development 127:3581-91. 2000
During vertebrate eye development, the optic vesicle is partitioned into a domain at its distal tip that will give rise to the neuroretina, and another at its proximal base that will give rise to the pigmented epithelium...
- Development and pathology of the hyaloid, choroidal and retinal vasculature
Schepens Eye Research Institute, Boston, MA 02114, USA
Int J Dev Biol 48:1045-58. 2004
During embryogenesis, the development and differentiation of the eye requires the concomitant formation of the neural/glial elements along with a dense vascular network...
- Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Development 128:491-502. 2001
..homozygotes also display myocardial hypoplasia, edema and hyperplasia of cells associated with the hyaloid vasculature of the eye. These data identify novel developmental roles for Notch2 in kidney, heart and eye development.
- WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
Ivan B Lobov
Division of Developmental Biology, The Children s Hospital Research Foundation and Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45229, USA
Nature 437:417-21. 2005
..and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions--including cell ..
- Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer
Christina I Swanson
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Dev Cell 18:359-70. 2010
- Eye tracking in infancy research
Department of Psychology, University of Oslo, Oslo, Norway
Dev Neuropsychol 35:1-19. 2010
The current review offers a unique introduction to the use of corneal reflection eye tracking in infancy research...
- Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study
Shamira A Perera
Glaucoma Service, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore
Arch Ophthalmol 128:900-5. 2010
..To explore the relationship of refractive error and ocular biometry with primary open-angle glaucoma (POAG) in the Malay population...
- BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome
Linda M Reis
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
Hum Genet 130:495-504. 2011
- Genetic basis of eye and pigment loss in the cave crustacean, Asellus aquaticus
Meredith E Protas
Department of Molecular and Cell Biology, Center of Integrative Genomics, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 108:5702-7. 2011
..map, composed of 117 markers, of which the majority are associated with genes known to be involved in pigmentation, eye, and appendage development, was used to identify loci of large effect responsible for several pigmentation traits ..
- Peter Pan functions independently of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis
Institute for Biochemistry and Molecular Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
Development 138:2369-78. 2011
..In this study, we demonstrate that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development...
- Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
Anthony A Attama
Institut fur Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
Int J Pharm 355:307-13. 2008
..of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal endothelial cells (HENC), stromal ..
- What clinical disorders tell us about the neural control of saccadic eye movements
University of Pavia, Pavia, Italy
Brain 130:10-35. 2007
Saccades are rapid eye movements that redirect the fovea from one object to another. A great deal has been learned about the anatomy and physiology of saccades, making them an ideal system for studying the neural control of movement...
- Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA
Dev Cell 14:399-410. 2008
..is preferentially employed in apoptotic proliferating tissues, Hh signaling is activated in differentiating eye tissues...
- Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics
Scott A Read
Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
Invest Ophthalmol Vis Sci 49:2911-8. 2008
To investigate the diurnal variation in axial length and anterior eye biometrics, while simultaneously measuring intraocular pressure (IOP) with dynamic contour tonometry in human subjects.
- BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis
Medical Research Council Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
Dev Cell 23:812-22. 2012
..However, the molecular events driving the differential regionalization of this area into eye-field and telencephalon fates are still unknown...
- Visualizing numbers in the mind's eye: the role of visuo-spatial processes in numerical abilities
Maria Dolores de Hevia
Universita degli Studi di Milano Bicocca, Italy
Neurosci Biobehav Rev 32:1361-72. 2008
..In this review behavioral, neuropsychological, and neuroimaging data concerning the close relationship between numerical abilities and visuo-spatial processes are considered...
- microRNA-24a is required to repress apoptosis in the developing neural retina
James C Walker
Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California at Berkeley, Berkeley, California 94720, USA
Genes Dev 23:1046-51. 2009
..Here, we report that miR-24a is expressed in the neural retina and is required for correct eye morphogenesis in Xenopus...
- A unique advantage for giant eyes in giant squid
Dan Eric Nilsson
Department of Biology, Lund University, 22362 Lund, Sweden
Curr Biol 22:683-8. 2012
..Our theory also provides insights into the vision of Mesozoic ichthyosaurs with unusually large eyes...
- Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye
Robert J Johnston
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Cell 145:956-68. 2011
..In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of ..
- Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
Daniel E Michele
Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 1101, USA
Nature 418:417-22. 2002
Muscle eye brain disease (MEB) and Fukuyama congenital muscular dystrophy (FCMD) are congenital muscular dystrophies with associated, similar brain malformations...
- COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
Development 137:725-34. 2010
Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development...
- Pax 6: mastering eye morphogenesis and eye evolution
W J Gehring
Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Trends Genet 15:371-7. 1999
Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis...
- Condition dependence of sexual ornament size and variation in the stalk-eyed fly Cyrtodiopsis dalmanni (Diptera: Diopsidae)
The Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, United Kingdom
Evolution 58:1038-46. 2004
..Thus, evaluation of male eyespan allows females to gain additional information about male condition over and above that given by body size. These findings accord well with condition-dependent handicap models of sexual selection...
- Direct interaction of geminin and Six3 in eye development
Filippo Del Bene
Developmental Biology Programme, EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Nature 427:745-9. 2004
..of the geminin gene (Gem; also known as Gmn) in medaka (Oryzias latipes) induces specific forebrain and eye defects that are rescued by Six3. Conversely, loss of Gem (in common with gain of Six3 (ref...
- A paraxial schematic eye model for the growing C57BL/6 mouse
Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
Vision Res 44:1857-67. 2004
The mouse eye has potential to become an important model for studies on the genetic control of eye growth and myopia. However, no data are published on the development of its optical properties...
- Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye
Jules Stein Eye Institute, Department of Neurobiology, University of California Los Angeles School of Medicine, Los Angeles, 90095-1689, USA
Am J Physiol Renal Physiol 281:F920-35. 2001
..present study, we determined the pattern of electrogenic sodium-bicarbonate cotransporter protein expression in rat eye. For this purpose, pNBC1- and kNBC1-specific antibodies were generated and used to detect these NBC1 protein ..
- The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye
N M Bonini
Division of Biology, California Institute of Technology, Pasadena 91125
Cell 72:379-95. 1993
The eyes absent (eya) gene is required at an early stage in development of the D. melanogaster compound eye. In eya mutants, progenitor cells in the eye disc undergo programmed cell death anterior to the morphogenetic furrow, rather than ..
- A hemispherical electronic eye camera based on compressible silicon optoelectronics
Heung Cho Ko
Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Nature 454:748-53. 2008
The human eye is a remarkable imaging device, with many attractive design features...
- The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development
Philip J Gage
Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, MI 48105, USA
Dev Biol 317:310-24. 2008
..signaling, is an essential downstream target of the PITX2 homeodomain transcription factor in neural crest during eye development...
- Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
D Jonathan Horsford
Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Development 132:177-87. 2005
During vertebrate eye development, the cells of the optic vesicle (OV) become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor ..
- Dendritic cell physiology and function in the eye
John V Forrester
Section of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
Immunol Rev 234:282-304. 2010
The eye and the brain are immunologically privileged sites, a property previously attributed to the lack of a lymphatic circulation...
- Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
Development 127:4325-34. 2000
..Based on our findings, we propose a model for Pax gene regulation that establishes the proper spatial regionalization of the mammalian visual system...
- The role of the retinal pigment epithelium in eye growth regulation and myopia: a review
School of Optometry, University of California Berkeley, 94720, USA
Vis Neurosci 22:251-61. 2005
..This has led to expanded research efforts to understand how ocular growth and refractive errors are regulated. Eye growth is sensitive to visual experience, and is altered by both form deprivation and optical defocus...
- Modern optics in exceptionally preserved eyes of Early Cambrian arthropods from Australia
Michael S Y Lee
South Australian Museum, North Terrace, Adelaide, South Australia 5000, Australia
Nature 474:631-4. 2011
Despite the status of the eye as an "organ of extreme perfection", theory suggests that complex eyes can evolve very rapidly...
- Cavefish as a model system in evolutionary developmental biology
W R Jeffery
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
Dev Biol 231:1-12. 2001
..The regressive changes include loss of pigmentation and eye degeneration...
- Expression and functions of heat shock proteins in the normal and pathological mammalian eye
A P Arrigo
Stress, Chaperons and Cell Death Laboratory, CNRS UMR 5534, Claude Bernard University Lyon 1, Villeurbanne, France
Curr Mol Med 10:776-93. 2010
..and function(s) of the different Hsps as an attempt to better understand their roles in the normal and pathological eye. Particular emphasis is given to the α-crystallin polypeptides which, in addition to their protective functions, ..
- Review of ocular immune privilege in the year 2010: modifying the immune privilege of the eye
Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
Ocul Immunol Inflamm 18:325-33. 2010
..was based on the prolonged survival of genetically disparate transplanted tissue in the anterior chamber of the eye. The failure of the immune system to elicit an immune response in this and other such sites constitutes the ..
- Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use
Jui Yang Lai
Institute of Biochemical and Biomedical Engineering, Chang Gung University, 33302, Taoyuan, Taiwan, Republic of China
J Mater Sci Mater Med 21:1899-911. 2010
..In comparison to GTA treatment, the EDC cross-linking is more suitable for preparation of chemically modified gelatin hydrogels for ophthalmic use...
- Eye and eyelid abnormalities are common in patients with Hashimoto's thyroiditis
Department of Medicine, Nepean Clinical School, The University of Sydney, Penrith, Australia
Thyroid 20:287-90. 2010
..is presumed to be uncommon in patients with Hashimoto's thyroiditis compared to Graves' disease, where significant eye changes are found in approximately 40% of patients...
- NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice
Holly L Rosenzweig
Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Invest Ophthalmol Vis Sci 50:1746-53. 2009
..Nonetheless, the role of NOD1 in intraocular inflammation has not been explored. The induction of uveitis by iE-DAP in mice and the potential contribution of interleukin (IL)-1beta were investigated...
- Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye
Martin P Kracklauer
Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
Fly (Austin) 1:75-85. 2007
..Klarsicht is a KASH protein required for nuclear migration in differentiating cells of the Drosophila eye. The C-terminal KASH domain of Klarsicht resides in the perinuclear space, and the cytoplasmic moiety connects to ..
- Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye
Ying Hsuan Wang
Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chia Yi, Taiwan
Dev Dyn 239:2522-33. 2010
..Many reports have demonstrated that the JAK/STAT pathway plays pleiotropic roles in Drosophila eye development...
- Replication study of significant single nucleotide polymorphisms associated with myopia from two genome-wide association studies
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, China
Mol Vis 17:3290-9. 2011
..The present study examined whether these markers are associated with myopia in a Chinese population...