eye

Summary

Top Publications

  1. ncbi The Rx homeobox gene is essential for vertebrate eye development
    P H Mathers
    Laboratory of Developmental Biology, Food and Drug Administration, Rockville, Maryland 20852, USA
    Nature 387:603-7. 1997
  2. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
  3. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
  4. pmc Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration
    Sylvain W Lapan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Rep 2:294-307. 2012
  5. pmc Eye contact detection in humans from birth
    Teresa Farroni
    Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom
    Proc Natl Acad Sci U S A 99:9602-5. 2002
  6. ncbi salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    Nicolas Tapon
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown 02129, USA
    Cell 110:467-78. 2002
  7. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
  8. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
  9. ncbi Stages of normal development in the medaka Oryzias latipes
    Takashi Iwamatsu
    Department of Biology, Aichi University of Education, 16 Terayamashita, Igaya cho, Kariya City, Aichi 448 0001, Japan
    Mech Dev 121:605-18. 2004
  10. pmc Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    BMC Biol 10:108. 2012

Research Grants

  1. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
  2. Amelioration of Uveitis by Aldose reductase Inhibition
    KOTA VENKATA RAMANA; Fiscal Year: 2010
  3. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
  4. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
  5. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
  6. Vision Research Infrastructure Development Grant (R24)
    FRANK GIBLIN; Fiscal Year: 2007
  7. Vision Research Infrastructure Development
    Henry Kaplan; Fiscal Year: 2008
  8. The stress of dry eye on corneal barrier function
    CINTIA DE PAIVA; Fiscal Year: 2006
  9. IN VIVO IMAGING IN AUTOIMMUNE UVEITIS
    Henry Kaplan; Fiscal Year: 2003
  10. HARVARD PROGRAM IN OCULAR IMMUNOLOGY
    Joan Stein Streilein; Fiscal Year: 2005

Detail Information

Publications278 found, 100 shown here

  1. ncbi The Rx homeobox gene is essential for vertebrate eye development
    P H Mathers
    Laboratory of Developmental Biology, Food and Drug Administration, Rockville, Maryland 20852, USA
    Nature 387:603-7. 1997
    Development of the vertebrate eye requires a series of steps including specification of the anterior neural plate, evagination of the optic vesicles from the ventral forebrain, and the cellular differentiation of the lens and retina...
  2. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
    ..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway.
  3. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    ..These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass...
  4. pmc Transcriptome analysis of the planarian eye identifies ovo as a specific regulator of eye regeneration
    Sylvain W Lapan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Rep 2:294-307. 2012
    Among the millions of invertebrate species with visual systems, the genetic basis of eye development and function is well understood only in Drosophila melanogaster...
  5. pmc Eye contact detection in humans from birth
    Teresa Farroni
    Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom
    Proc Natl Acad Sci U S A 99:9602-5. 2002
    Making eye contact is the most powerful mode of establishing a communicative link between humans. During their first year of life, infants learn rapidly that the looking behaviors of others conveys significant information...
  6. ncbi salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    Nicolas Tapon
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown 02129, USA
    Cell 110:467-78. 2002
    ..The human ortholog of salvador (hWW45) is mutated in three cancer cell lines. Thus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis...
  7. ncbi The impact of ocular blood flow in glaucoma
    Josef Flammer
    University Eye Clinic, Basel, Switzerland
    Prog Retin Eye Res 21:359-93. 2002
    ..This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP...
  8. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
    The Drosophila eye has contributed much to our knowledge of cell differentiation...
  9. ncbi Stages of normal development in the medaka Oryzias latipes
    Takashi Iwamatsu
    Department of Biology, Aichi University of Education, 16 Terayamashita, Igaya cho, Kariya City, Aichi 448 0001, Japan
    Mech Dev 121:605-18. 2004
    ..After hatching, development of the larvae (fry) and young can be divided into six stages based on such diagnostic features as the fins, scales and secondary sexual characteristics...
  10. pmc Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    BMC Biol 10:108. 2012
    ..More recently, several different adaptive hypotheses have been proposed to explain eye degeneration based on studies in the teleost Astyanax mexicanus, which consists of blind cave-dwelling (cavefish) ..
  11. ncbi The role of Pax-6 in eye and nasal development
    J C Grindley
    Developmental Genetics Section, Western General Hospital, Edinburgh, UK
    Development 121:1433-42. 1995
    Small eye (Sey) mice homozygous for mutations in the Pax-6 gene have no lenses and no nasal cavities...
  12. pmc Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models
    Thirumurthy Velpandian
    Department of Ocular Pharmacology and Pharmacy, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India
    BMC Complement Altern Med 13:1. 2013
    The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies...
  13. ncbi Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
    Detlev Arendt
    Developmental Biology Department, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Science 306:869-71. 2004
    ..Comparative analysis indicates that both types of photoreceptors, with distinct opsins, coexisted in Urbilateria, the last common ancestor of insects and vertebrates, and sheds new light on vertebrate eye evolution.
  14. pmc Regressive evolution in the Mexican cave tetra, Astyanax mexicanus
    Meredith Protas
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 17:452-4. 2007
    ..and pigmentation in cave-adapted animals are unknown; Darwin famously questioned the role of natural selection in eye loss in cave fishes: "As it is difficult to imagine that eyes, although useless, could be in any way injurious ..
  15. ncbi Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4293-301. 2004
    To evaluate whether experimentally induced dry eye in mice activates mitogen-activated protein kinase (MAPK) signaling pathways, c-Jun N-terminal kinases (JNK), extracellular-regulated kinases (ERK), and p38 and stimulates ocular surface ..
  16. pmc Eye morphogenesis and patterning of the optic vesicle
    Sabine Fuhrmann
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA
    Curr Top Dev Biol 93:61-84. 2010
    Organogenesis of the eye is a multistep process that starts with the formation of optic vesicles followed by invagination of the distal domain of the vesicles and the overlying lens placode resulting in morphogenesis of the optic cup...
  17. pmc Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    Brian S Robinson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 20:582-90. 2010
    ....
  18. pmc Design principles of insect and vertebrate visual systems
    Joshua R Sanes
    Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 66:15-36. 2010
    ....
  19. ncbi Eye development
    Jochen Graw
    Helmholtz Center Munich German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    Curr Top Dev Biol 90:343-86. 2010
    The vertebrate eye comprises tissues from different embryonic origins: the lens and the cornea are derived from the surface ectoderm, but the retina and the epithelial layers of the iris and ciliary body are from the anterior neural ..
  20. ncbi Hedgehog signalling controls eye degeneration in blind cavefish
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nature 431:844-7. 2004
    ..Here we show that hh gene expression at the embryonic midline controls eye degeneration in blind cavefish...
  21. pmc Melanopsin: An opsin in melanophores, brain, and eye
    I Provencio
    Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 95:340-5. 1998
    ..Its expression in retinal and nonretinal tissues suggests a role in vision and nonvisual photoreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and photoperiodic physiology...
  22. pmc Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development
    Qin Yan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Natl Acad Sci U S A 107:21034-9. 2010
    Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development. Four Pax-6 isoforms have been reported previously...
  23. pmc miRNeye: a microRNA expression atlas of the mouse eye
    Marianthi Karali
    Telethon Institute for Genetics and Medicine, Via P Castellino 111, Naples, Italy
    BMC Genomics 11:715. 2010
    MicroRNAs (miRNAs) are key regulators of biological processes. To define miRNA function in the eye, it is essential to determine a high-resolution profile of their spatial and temporal distribution.
  24. pmc Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development
    Yufei Xu
    Division of Endocrinology, Diabetes and Hypertension, Departments of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 151:1200-13. 2012
    ..Here, we report that Xenopus Tet3 plays an essential role in early eye and neural development by directly regulating a set of key developmental genes...
  25. pmc Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:1169-78. 2008
    During vertebrate eye development, the transcription factor MITF plays central roles in neuroepithelial domain specification and differentiation of the retinal pigment epithelium...
  26. ncbi Eyes always attract attention but gaze orienting is task-dependent: evidence from eye movement monitoring
    Roxane J Itier
    The Rotman Research Institute, Baycrest, Toronto, Canada
    Neuropsychologia 45:1019-28. 2007
    ..Here, the shift in attention towards the eye region and gaze direction of a perceived face was studied in two tasks by monitoring eye movements...
  27. pmc Does it make a difference if I have an eye contact with you or with your picture? An ERP study
    Laura M Pönkänen
    Department of Psychology, FIN 33014, University of Tampere, Finland
    Soc Cogn Affect Neurosci 6:486-94. 2011
    Several recent studies have begun to examine the neurocognitive mechanisms involved in perceiving and responding to eye contact, a salient social signal of interest and readiness for interaction...
  28. ncbi Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range
    Michalina Gora
    Institute of Physics, Nicolaus Copernicus University, ul Grudziadzka 5 7, PL 87 100 Torun, Poland
    Opt Express 17:14880-94. 2009
    We present an application of in vivo anterior segment imaging of the human eye with an ultrahigh speed swept source OCT instrument. For this purpose, a dedicated OCT system was designed and constructed...
  29. ncbi Pax-6, a murine paired box gene, is expressed in the developing CNS
    C Walther
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Germany
    Development 113:1435-49. 1991
    ..5 of development. Pax-6 is also expressed in the developing eye, the pituitary and the nasal epithelium.
  30. pmc Gene flow and population structure in the Mexican blind cavefish complex (Astyanax mexicanus)
    Martina Bradić
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Oeiras, 2780 157, Portugal
    BMC Evol Biol 12:9. 2012
    ....
  31. ncbi Emotion recognition in children with autism spectrum disorders: relations to eye gaze and autonomic state
    Elgiz Bal
    Department of Psychiatry MC 912, Brain Body Center, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL, 60612, USA
    J Autism Dev Disord 40:358-70. 2010
    ..Within the ASD group, children with higher amplitude RSA recognized emotions faster. Less severe ASD symptoms and increased gaze to the eye region in children with ASD were related to more accurate emotion recognition.
  32. ncbi Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    G Halder
    Biozentrum, University of Basel, Switzerland
    Science 267:1788-92. 1995
    ..It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans...
  33. pmc Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    H Wayne Peng
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Genes Dev 23:2307-19. 2009
    ..Tsh), two DNA-binding transcription factors expressed in the uncommitted progenitor cells of the Drosophila eye imaginal disc...
  34. pmc A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
    R S Stowers
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 152:1631-9. 1999
    ..called EGUF/hid) that uses both the GAL4/UAS and FLP/FRT systems to overcome this limitation for the Drosophila eye by producing genetically mosaic flies that are otherwise heterozygous but in which the eye is composed exclusively ..
  35. pmc Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations
    Sophie I Candille
    Department of Genetics, Stanford University, Stanford, California, United States of America
    PLoS ONE 7:e48294. 2012
    ..But skin, hair, and eye pigmentation vary continuously...
  36. ncbi Neurogenic potential of stem/progenitor-like cells in the adult mammalian eye
    Stefanie G Wohl
    Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany
    Prog Retin Eye Res 31:213-42. 2012
    ..Herein, we particularly feature the adult rodent eye and provide an overview of all putative neuronal progenitor-like cells attributed to the various ocular areas that ..
  37. pmc Eye evolution and its functional basis
    Dan E Nilsson
    Department of Biology, Lund Vision Group, Lund University, Lund, Sweden
    Vis Neurosci 30:5-20. 2013
    b>Eye evolution is driven by the evolution of visually guided behavior. Accumulation of gradually more demanding behaviors have continuously increased the performance requirements on the photoreceptor organs...
  38. ncbi Restoring eye size in Astyanax mexicanus blind cavefish embryos through modulation of the Shh and Fgf8 forebrain organising centres
    Karen Pottin
    Equipe Développement Evolution du Cerveau Antérieur, UPR3294 NED, CNRS, Institut Alfred Fessard, 91198 Gif sur Yvette, France
    Development 138:2467-76. 2011
    The cavefish morph of the Mexican tetra (Astyanax mexicanus) is blind at adult stage, although an eye that includes a retina and a lens develops during embryogenesis. There are, however, two major defects in cavefish eye development...
  39. pmc Exaggerated eye growth in IRBP-deficient mice in early development
    Jeffrey Wisard
    Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 52:5804-11. 2011
    Because interphotoreceptor retinoid-binding protein (IRBP) is expressed before being needed in its presumptive role in the visual cycle, we tested whether it controls eye growth during development.
  40. pmc A look at autoimmunity and inflammation in the eye
    Rachel R Caspi
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:3073-83. 2010
    ....
  41. pmc scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    Anthony M Brumby
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    EMBO J 22:5769-79. 2003
    ..We show that scribble mutant clones in the eye disc exhibit ectopic expression of cyclin E and ectopic cell cycles, but do not overgrow due to increased cell ..
  42. pmc Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis
    Vaibhav P Pai
    Department of Biology and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155, USA
    Development 139:313-23. 2012
    Uncovering the molecular mechanisms of eye development is crucial for understanding the embryonic morphogenesis of complex structures, as well as for the establishment of novel biomedical approaches to address birth defects and injuries ..
  43. ncbi Early eye development in vertebrates
    R L Chow
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Annu Rev Cell Dev Biol 17:255-96. 2001
    ..a synthesis that combines data from classical experimentation and recent advances in our understanding of early eye development. Emphasis is placed on the events that underlie and direct neural retina formation and lens induction...
  44. ncbi Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
    G Oliver
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 121:4045-55. 1995
    ..gene is known to play an essential role in controlling the initial events of pattern formation in the eye disc and is also required for the development of other parts of the fly visual system including the optic lobes...
  45. pmc Rapid evolutionary rewiring of a structurally constrained eye enhancer
    Christina I Swanson
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Curr Biol 21:1186-96. 2011
    ..Here, we examine evolutionary changes to the sequence and structure of sparkling, a Notch/EGFR/Runx-regulated enhancer that activates the dPax2 gene in cone cells of the developing Drosophila eye.
  46. pmc The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition
    Ru Zhou
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    J Immunol 188:1742-50. 2012
    Immune privilege is used by the eye, brain, reproductive organs, and gut to preserve structural and functional integrity in the face of inflammation...
  47. pmc The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development
    Jón H Hallsson
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 167:233-41. 2004
    ..for the development of several different cell types, including the retinal pigment epithelial (RPE) cells of the eye. In Mitf mutant mice, the presumptive RPE cells hyperproliferate, abnormally express the retinal transcriptional ..
  48. pmc Mutations Modulating Raf signaling in Drosophila eye development
    B J Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genetics 142:163-71. 1996
    The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase...
  49. pmc Dorsal premotor neurons encode the relative position of the hand, eye, and goal during reach planning
    Bijan Pesaran
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 51:125-34. 2006
    ..intraparietal area (area MIP) of two monkeys while systematically varying the starting position of the hand and eye during reaching. PMd neurons encoded the relative position of the target, hand, and eye...
  50. ncbi Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    J M Warrick
    Department of Biology, University of Pennsylvania and University of Pennsylvania Medical School, Philadelphia 19104, USA
    Cell 93:939-49. 1998
    ..Our results demonstrate that cellular mechanisms of human glutamine-repeat disease are conserved in invertebrates. This fly model will aid in identifying additional factors that modulate neurodegeneration...
  51. pmc Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways
    Preeti Bakrania
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Am J Hum Genet 82:304-19. 2008
    ..Our finding of low-penetrant variants in BMP4 and HH signaling partners is suggestive of an interaction between the two pathways in humans...
  52. pmc Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome
    Peng Jin
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 55:556-64. 2007
    ..These findings support the disease mechanism of FXTAS of rCGG repeat sequestration of specific RBPs, leading to neuronal cell death, and implicate that Pur alpha plays an important role in the pathogenesis of FXTAS...
  53. ncbi Cyclosporine A delivery to the eye: a pharmaceutical challenge
    F Lallemand
    School of Pharmacy, University of Geneva, Geneva, Switzerland
    Eur J Pharm Biopharm 56:307-18. 2003
    ..of local ophthalmic conditions involving cytokines, such as corneal graft rejection, autoimmune uveitis and dry eye syndrome. Local administration is expected to avoid the various side effects associated with systemic delivery...
  54. ncbi Individual cell migration serves as the driving force for optic vesicle evagination
    Martina Rembold
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 313:1130-4. 2006
    The cellular mechanisms underlying organ formation are largely unknown. We visualized early vertebrate eye morphogenesis at single-cell resolution by in vivo imaging in medaka (Oryzias latipes)...
  55. pmc Regressive evolution in Astyanax cavefish
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Annu Rev Genet 43:25-47. 2009
    ....
  56. pmc Neural bases of eye and gaze processing: the core of social cognition
    Roxane J Itier
    Psychology Department, University of Waterloo, Ontario, Canada
    Neurosci Biobehav Rev 33:843-63. 2009
    ..attention and intentions of others could be linked to difficulties in extracting the relevant information from the eye region including gaze direction. In this review, we address the central role of eyes and gaze in social cognition...
  57. pmc Intersubject variability of foveal cone photoreceptor density in relation to eye length
    Kaccie Y Li
    School of Optometry, University of California, Berkeley, CA 94720 2020, USA
    Invest Ophthalmol Vis Sci 51:6858-67. 2010
    ..The intersubject variability of foveal cone density was measured and its relation to eye length evaluated.
  58. ncbi The arrangement of the three cone classes in the living human eye
    A Roorda
    Center for Visual Science, University of Rochester, New York 14627, USA
    Nature 397:520-2. 1999
    ..Adaptive optics, a technique used to overcome blur in ground-based telescopes, can also overcome blur in the eye, allowing the sharpest images ever taken of the living retina...
  59. ncbi Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF
    M Nguyen
    Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Development 127:3581-91. 2000
    During vertebrate eye development, the optic vesicle is partitioned into a domain at its distal tip that will give rise to the neuroretina, and another at its proximal base that will give rise to the pigmented epithelium...
  60. ncbi Development and pathology of the hyaloid, choroidal and retinal vasculature
    Magali Saint-Geniez
    Schepens Eye Research Institute, Boston, MA 02114, USA
    Int J Dev Biol 48:1045-58. 2004
    During embryogenesis, the development and differentiation of the eye requires the concomitant formation of the neural/glial elements along with a dense vascular network...
  61. ncbi Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
    B McCright
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 128:491-502. 2001
    ..homozygotes also display myocardial hypoplasia, edema and hyperplasia of cells associated with the hyaloid vasculature of the eye. These data identify novel developmental roles for Notch2 in kidney, heart and eye development.
  62. pmc WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
    Ivan B Lobov
    Division of Developmental Biology, The Children s Hospital Research Foundation and Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Nature 437:417-21. 2005
    ..and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions--including cell ..
  63. pmc Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer
    Christina I Swanson
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Dev Cell 18:359-70. 2010
    ....
  64. ncbi Eye tracking in infancy research
    Gustaf Gredeback
    Department of Psychology, University of Oslo, Oslo, Norway
    Dev Neuropsychol 35:1-19. 2010
    The current review offers a unique introduction to the use of corneal reflection eye tracking in infancy research...
  65. ncbi Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study
    Shamira A Perera
    Glaucoma Service, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore
    Arch Ophthalmol 128:900-5. 2010
    ..To explore the relationship of refractive error and ocular biometry with primary open-angle glaucoma (POAG) in the Malay population...
  66. pmc BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome
    Linda M Reis
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Hum Genet 130:495-504. 2011
    ....
  67. pmc Genetic basis of eye and pigment loss in the cave crustacean, Asellus aquaticus
    Meredith E Protas
    Department of Molecular and Cell Biology, Center of Integrative Genomics, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 108:5702-7. 2011
    ..map, composed of 117 markers, of which the majority are associated with genes known to be involved in pigmentation, eye, and appendage development, was used to identify loci of large effect responsible for several pigmentation traits ..
  68. ncbi Peter Pan functions independently of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis
    Verena Bugner
    Institute for Biochemistry and Molecular Biology, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
    Development 138:2369-78. 2011
    ..In this study, we demonstrate that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development...
  69. ncbi Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
    Anthony A Attama
    Institut fur Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
    Int J Pharm 355:307-13. 2008
    ..of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal endothelial cells (HENC), stromal ..
  70. ncbi What clinical disorders tell us about the neural control of saccadic eye movements
    Stefano Ramat
    University of Pavia, Pavia, Italy
    Brain 130:10-35. 2007
    Saccades are rapid eye movements that redirect the fovea from one object to another. A great deal has been learned about the anatomy and physiology of saccades, making them an ideal system for studying the neural control of movement...
  71. pmc Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye
    Yun Fan
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA
    Dev Cell 14:399-410. 2008
    ..is preferentially employed in apoptotic proliferating tissues, Hh signaling is activated in differentiating eye tissues...
  72. ncbi Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics
    Scott A Read
    Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of Technology, Brisbane, Queensland, Australia
    Invest Ophthalmol Vis Sci 49:2911-8. 2008
    To investigate the diurnal variation in axial length and anterior eye biometrics, while simultaneously measuring intraocular pressure (IOP) with dynamic contour tonometry in human subjects.
  73. ncbi BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis
    Holger Bielen
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Dev Cell 23:812-22. 2012
    ..However, the molecular events driving the differential regionalization of this area into eye-field and telencephalon fates are still unknown...
  74. ncbi Visualizing numbers in the mind's eye: the role of visuo-spatial processes in numerical abilities
    Maria Dolores de Hevia
    Universita degli Studi di Milano Bicocca, Italy
    Neurosci Biobehav Rev 32:1361-72. 2008
    ..In this review behavioral, neuropsychological, and neuroimaging data concerning the close relationship between numerical abilities and visuo-spatial processes are considered...
  75. pmc microRNA-24a is required to repress apoptosis in the developing neural retina
    James C Walker
    Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 23:1046-51. 2009
    ..Here, we report that miR-24a is expressed in the neural retina and is required for correct eye morphogenesis in Xenopus...
  76. ncbi A unique advantage for giant eyes in giant squid
    Dan Eric Nilsson
    Department of Biology, Lund University, 22362 Lund, Sweden
    Curr Biol 22:683-8. 2012
    ..Our theory also provides insights into the vision of Mesozoic ichthyosaurs with unusually large eyes...
  77. pmc Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye
    Robert J Johnston
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 145:956-68. 2011
    ..In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of ..
  78. ncbi Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
    Daniel E Michele
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Nature 418:417-22. 2002
    Muscle eye brain disease (MEB) and Fukuyama congenital muscular dystrophy (FCMD) are congenital muscular dystrophies with associated, similar brain malformations...
  79. pmc COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
    Ke Tang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Development 137:725-34. 2010
    Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development...
  80. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis...
  81. ncbi Condition dependence of sexual ornament size and variation in the stalk-eyed fly Cyrtodiopsis dalmanni (Diptera: Diopsidae)
    Samuel Cotton
    The Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, United Kingdom
    Evolution 58:1038-46. 2004
    ..Thus, evaluation of male eyespan allows females to gain additional information about male condition over and above that given by body size. These findings accord well with condition-dependent handicap models of sexual selection...
  82. ncbi Direct interaction of geminin and Six3 in eye development
    Filippo Del Bene
    Developmental Biology Programme, EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Nature 427:745-9. 2004
    ..of the geminin gene (Gem; also known as Gmn) in medaka (Oryzias latipes) induces specific forebrain and eye defects that are rescued by Six3. Conversely, loss of Gem (in common with gain of Six3 (ref...
  83. ncbi A paraxial schematic eye model for the growing C57BL/6 mouse
    Christine Schmucker
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Vision Res 44:1857-67. 2004
    The mouse eye has potential to become an important model for studies on the genetic control of eye growth and myopia. However, no data are published on the development of its optical properties...
  84. ncbi Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye
    D Bok
    Jules Stein Eye Institute, Department of Neurobiology, University of California Los Angeles School of Medicine, Los Angeles, 90095-1689, USA
    Am J Physiol Renal Physiol 281:F920-35. 2001
    ..present study, we determined the pattern of electrogenic sodium-bicarbonate cotransporter protein expression in rat eye. For this purpose, pNBC1- and kNBC1-specific antibodies were generated and used to detect these NBC1 protein ..
  85. ncbi The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye
    N M Bonini
    Division of Biology, California Institute of Technology, Pasadena 91125
    Cell 72:379-95. 1993
    The eyes absent (eya) gene is required at an early stage in development of the D. melanogaster compound eye. In eya mutants, progenitor cells in the eye disc undergo programmed cell death anterior to the morphogenetic furrow, rather than ..
  86. ncbi A hemispherical electronic eye camera based on compressible silicon optoelectronics
    Heung Cho Ko
    Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nature 454:748-53. 2008
    The human eye is a remarkable imaging device, with many attractive design features...
  87. pmc The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development
    Philip J Gage
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Dev Biol 317:310-24. 2008
    ..signaling, is an essential downstream target of the PITX2 homeodomain transcription factor in neural crest during eye development...
  88. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
    During vertebrate eye development, the cells of the optic vesicle (OV) become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor ..
  89. ncbi Dendritic cell physiology and function in the eye
    John V Forrester
    Section of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Immunol Rev 234:282-304. 2010
    The eye and the brain are immunologically privileged sites, a property previously attributed to the lack of a lymphatic circulation...
  90. ncbi Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
    M Schwarz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 127:4325-34. 2000
    ..Based on our findings, we propose a model for Pax gene regulation that establishes the proper spatial regionalization of the mammalian visual system...
  91. ncbi The role of the retinal pigment epithelium in eye growth regulation and myopia: a review
    Jodi Rymer
    School of Optometry, University of California Berkeley, 94720, USA
    Vis Neurosci 22:251-61. 2005
    ..This has led to expanded research efforts to understand how ocular growth and refractive errors are regulated. Eye growth is sensitive to visual experience, and is altered by both form deprivation and optical defocus...
  92. ncbi Modern optics in exceptionally preserved eyes of Early Cambrian arthropods from Australia
    Michael S Y Lee
    South Australian Museum, North Terrace, Adelaide, South Australia 5000, Australia
    Nature 474:631-4. 2011
    Despite the status of the eye as an "organ of extreme perfection", theory suggests that complex eyes can evolve very rapidly...
  93. ncbi Cavefish as a model system in evolutionary developmental biology
    W R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Dev Biol 231:1-12. 2001
    ..The regressive changes include loss of pigmentation and eye degeneration...
  94. ncbi Expression and functions of heat shock proteins in the normal and pathological mammalian eye
    A P Arrigo
    Stress, Chaperons and Cell Death Laboratory, CNRS UMR 5534, Claude Bernard University Lyon 1, Villeurbanne, France
    Curr Mol Med 10:776-93. 2010
    ..and function(s) of the different Hsps as an attempt to better understand their roles in the normal and pathological eye. Particular emphasis is given to the α-crystallin polypeptides which, in addition to their protective functions, ..
  95. ncbi Review of ocular immune privilege in the year 2010: modifying the immune privilege of the eye
    Junko Hori
    Department of Ophthalmology, Nippon Medical School, Tokyo, Japan
    Ocul Immunol Inflamm 18:325-33. 2010
    ..was based on the prolonged survival of genetically disparate transplanted tissue in the anterior chamber of the eye. The failure of the immune system to elicit an immune response in this and other such sites constitutes the ..
  96. ncbi Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, 33302, Taoyuan, Taiwan, Republic of China
    J Mater Sci Mater Med 21:1899-911. 2010
    ..In comparison to GTA treatment, the EDC cross-linking is more suitable for preparation of chemically modified gelatin hydrogels for ophthalmic use...
  97. ncbi Eye and eyelid abnormalities are common in patients with Hashimoto's thyroiditis
    Hilman Tjiang
    Department of Medicine, Nepean Clinical School, The University of Sydney, Penrith, Australia
    Thyroid 20:287-90. 2010
    ..is presumed to be uncommon in patients with Hashimoto's thyroiditis compared to Graves' disease, where significant eye changes are found in approximately 40% of patients...
  98. pmc NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1746-53. 2009
    ..Nonetheless, the role of NOD1 in intraocular inflammation has not been explored. The induction of uveitis by iE-DAP in mice and the potential contribution of interleukin (IL)-1beta were investigated...
  99. ncbi Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye
    Martin P Kracklauer
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    Fly (Austin) 1:75-85. 2007
    ..Klarsicht is a KASH protein required for nuclear migration in differentiating cells of the Drosophila eye. The C-terminal KASH domain of Klarsicht resides in the perinuclear space, and the cytoplasmic moiety connects to ..
  100. pmc Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye
    Ying Hsuan Wang
    Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chia Yi, Taiwan
    Dev Dyn 239:2522-33. 2010
    ..Many reports have demonstrated that the JAK/STAT pathway plays pleiotropic roles in Drosophila eye development...
  101. pmc Replication study of significant single nucleotide polymorphisms associated with myopia from two genome-wide association studies
    Qin Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, China
    Mol Vis 17:3290-9. 2011
    ..The present study examined whether these markers are associated with myopia in a Chinese population...

Research Grants68

  1. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  2. Amelioration of Uveitis by Aldose reductase Inhibition
    KOTA VENKATA RAMANA; Fiscal Year: 2010
    ..Uveitis may result from direct involvement of the uveal tract or indirect inflammation of adjacent eye tissues...
  3. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Thus, this proposal seeks to investigate Nod2 expression in the eye and examine how disease-associated mutations in Nod2 alter cellular inflammatory functions...
  4. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..e., irritation) and eye irritation, two frequently mentioned adverse symptoms arising from indoor (e.g...
  5. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..e., chemesthetic or chemical sensory irritation) detectability by humans. Chemesthetic detection will include eye irritation and nasal localization (i.e...
  6. Vision Research Infrastructure Development Grant (R24)
    FRANK GIBLIN; Fiscal Year: 2007
    ..Ten investigators, seven from the Eye Research Institute at O.U. and three from the O.U...
  7. Vision Research Infrastructure Development
    Henry Kaplan; Fiscal Year: 2008
    ..These services and resources will enhance vision research at the University of Louisville by extending the capability of NEI funded scientists, promoting collaboration and attracting new scientist to vision research. ..
  8. The stress of dry eye on corneal barrier function
    CINTIA DE PAIVA; Fiscal Year: 2006
    ..provided by applicant): The project will study the response of the tight junctions (TJ) to experimental dry eye (EDE) on the corneal epithelium with specific emphasis on the perturbation of corneal epithelial barrier function...
  9. IN VIVO IMAGING IN AUTOIMMUNE UVEITIS
    Henry Kaplan; Fiscal Year: 2003
    ..anterior uveitis (AAU), the most common form of intraocular inflammation in man, is an autoimmune disease of the eye. Experimental autoimmune anterior uveitis (EAAU) is a rodent model of AAU...
  10. HARVARD PROGRAM IN OCULAR IMMUNOLOGY
    Joan Stein Streilein; Fiscal Year: 2005
    DESCRIPTION: (Applicant's Abstract) The National Eye Institute currently sponsors several programs in ocular immunology, many of which are based in laboratories of Harvard Medical School faculty members...
  11. Ultrasound-Enhanced Delivery of Medications to the Eye
    Ronald Silverman; Fiscal Year: 2008
    Ultrasound-Enhanced Delivery of Medications to the Eye Project Summary The objective of this project is the development of a safe and effective means to deliver macromolecular drugs across the wall of the eye for treatment of disease, ..
  12. KININ/PGE INTERACTION IN CONTROL OF INTRAOCULAR PRESSURE
    JERRY WEBB; Fiscal Year: 2009
    ..The working hypothesis is that kinins, produced locally within the eye, act in an autocrine/paracrine fashion to regulate conventional outflow by modulating secretion of matrix ..
  13. CHEMOKINE REGULATION OF NKT CELLS, AND ACAID
    Joan Stein Streilein; Fiscal Year: 2003
    ..the selective negative regulation of delayed type hypersensitivity (DTH) after the introduction of antigen into the eye. An accumulation of splenic NKT cells is absolutely required for the development of ACAID...
  14. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
    ....
  15. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ....
  16. Targeting drug-delivery nanoparticles to sites of inflammation
    Henry Kaplan; Fiscal Year: 2006
    ..These treatments are severely limited by the fact that the drug must be directly injected into the eye. This procedure carries a significant risk of complication and generates understandable issues of patient ..
  17. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2009
    ..Relevance Statement: The goals of this project are to gain a greater understanding of the genetic basis of the eye disorders myopia and glaucoma. Achievement of this goal requires cooperative efforts and large sample sizes...
  18. EAAU--ANTIGEN STRUCTURE AND THERAPY
    Henry Kaplan; Fiscal Year: 2001
    ..Experimental autoimmune anterior uveitis (EAAU)is an organ specific autoimmune disease of the eye, which resembles AAU...
  19. ANTERIOR CHAMBER INFLUENCE ON OCULAR ANTIGENS
    Joan Stein Streilein; Fiscal Year: 2005
    ..If the eye is altered by inflammation, trauma or disease, its capacity to promote ACAID is abolished...
  20. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2002
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  21. INDUCED APOPTOSIS IN AGE RELATED MACULAR DEGENERATION
    Thomas Ferguson; Fiscal Year: 2002
    ..We recently examined the role of apoptosis in controlling new vessel growth in the eye by examining the function of two molecules, Fas (CD95) and FasL (CD95L)...
  22. Regulation of ACAID by lymphocytes with NK markers
    Joan Stein Streilein; Fiscal Year: 2010
    ..Here, we will study a model for peripheral tolerance that can be induced through the eye called Anterior Chamber Associated Immune Deviation (ACAID)...
  23. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  24. IMMUNOBIOLOGY OF CORNEAL TRANSPLANATION
    Joan Stein Streilein; Fiscal Year: 2004
    ..Moreover, we anticipate that our results will suggest novel strategies that could be used therapeutically to promote graft acceptance in clinical situations where graft failure is all too common. ..
  25. Identification of Genetic Modifiers of an Epstein-Barr Virus Protein.
    AMY ADAMSON; Fiscal Year: 2007
    ..Our studies aim to find human genes whose protein products enhance or suppress Epstein-Barr virus protein activity. [unreadable] [unreadable] [unreadable]..
  26. Dendritic Cell Vaccination During Lymphoid Reconstitution
    Jeffrey Weber; Fiscal Year: 2008
    ..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
  27. Regulation of Corneal Inflammation by Fas Ligand
    Victor Perez; Fiscal Year: 2007
    ..The Cole Eye Institute and the Immunology Department at the Cleveland Clinic Foundation provide the clinical and basic science ..
  28. IMAGING OF ROD OUTER SEGMENT BY CRYO-ELECTRON TOMOGRAPHY
    Krzysztof Palczewski; Fiscal Year: 2008
    ..These studies will add significantly to our understanding of the normal and disease stage organization of the rod outer segments. [unreadable] [unreadable] [unreadable]..
  29. Selfish gene and genetic control of vector-borne diseases
    ZACH ADELMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  31. Photic and Nonphotic Input to the Human Circadian System
    STEVEN LOCKLEY; Fiscal Year: 2008
    ..limits of entrainment for non-photic synchronizers in order to potentially evaluate the efficacy of such time cues for treatment of circadian rhythm sleep-wake disorders in both the blind and sighted populations [unreadable] [unreadable]..
  32. Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Michael J Stern; Fiscal Year: 2010
    ..We further propose that the severity of this ALKC is worsened by defective self tolerance mechanisms. ..
  33. Role of Protein Ubiquitination in Angiogenesis
    Nader Rahimi; Fiscal Year: 2010
    ..presents an attractive and certainly wide- ranging therapy for many human diseases ranging from cancer to eye diseases...
  34. Racial Variations in Optic Nerve Head Structure and Biomechanics
    J CRAWFORD contact DOWNS; Fiscal Year: 2011
    ....
  35. Fragments of TrpRS to Treat Neovascular Eye Diseases
    Martin Friedlander; Fiscal Year: 2006
    ..of TrpRS fragments and identify a candidate drug and delivery system for use in clinical trials of neovascular eye diseases...
  36. OCULAR DEVELOPMENT IN INFANCY/EARLY CHILDHOOD
    Donald Mutti; Fiscal Year: 2005
    ..Despite continued growth of the eye after the age of three, emmetropia is maintained in most children until the age of about nine years...
  37. New England College of Optometry Vision Core Grant
    NANCY COLETTA; Fiscal Year: 2007
    ..For example, experimental approaches used at the college in the study of eye growth and myopia development involve human and non-human subjects, and behavioral, clinical, and basic biological ..
  38. STRUCTURAL STUDIES OF G PROTEIN-COUPLED RECEPTORS
    KRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2010
    ..The importance of the protein family for human health makes this effort worthwhile. ..
  39. MYOPIA AND OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 2004
    ..Much evidence identifies the retina itself as exerting the dominant influence on eye growth and refraction, with perhaps some modulation from other components of the nervous system...
  40. EXTRACELLULAR MATRIX AND NEUROMUSCULAR DEVELOPMENT
    Joshua Sanes; Fiscal Year: 2004
    ..Through this work, we hope to gain insight into molecules and mechanisms necessary for construction of synapses, which are the fundamental information-processing units of the nervous system. ..
  41. NEUROGENESIS AND DEVELOPMENT OF THE VISUAL SYSTEM
    RUSSELL FERNALD; Fiscal Year: 2004
    ..Since in our retinal model new rod photoreceptors are integrated into fully functional retinal tissue, this may serve as a particularly useful model for understanding adult neurogenesis. ..
  42. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  43. Disease and Continuous Myofiber Remodeling in EOM
    Linda McLoon; Fiscal Year: 2004
    ..Ultimately, we hope to use this information to develop new therapeutic strategies.for the treatment of strabismus and other ocular and non-ocular muscle diseases. ..
  44. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  45. The Signal Transduction Mechanism of Interleukin-5
    Rafeul Alam; Fiscal Year: 2005
    ..Lyn and IRIP may represent excellent therapeutic targets for intervention in asthma and other allergic diseases. ..
  46. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  47. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  48. Regulation of guanylyl cyclase
    Ferid Murad; Fiscal Year: 2005
    ..The knowledge of the mechanism of sGC regulation will advance our understanding of the role of sGC/cGMP system in various biological processes. ..
  49. TRANSTHYRETIN DEPOSITION IN AGING TRANSGENIC MICE
    Joel Buxbaum; Fiscal Year: 2004
    ..Investigation of the model may allow us to identify and study such mechanisms which, in turn, may provide insight into aging and offer potential therapeutic targets in more than one form of human amyloidosis. ..
  50. ESTABLISHMENT OF POLARITY IN RETINAL DEVELOPMENT
    Tanya Wolff; Fiscal Year: 2003
    ..A second specific aim of this work is to use genetic and biochemical screens to identify genes and proteins that interact with stbm to orient cells in a coordinated fashion in epithelia. ..
  51. Cellular Proliferation and Differentiation in the Retina
    Jeffrey Gross; Fiscal Year: 2005
    ..are distributed asymmetrically during retinogenesis and what roles such determinants play in cell fate choices in the retina and 3) to utilize chemical screens for compounds that affect proliferation and differentiation in the retina ..
  52. Genetic Modifiers of Epstein-Barr Virus/Host Interactns
    AMY ADAMSON; Fiscal Year: 2003
    ..The results from this genetic screen will shed light onto the mechanisms by which EBV alters normal cellular functions, as well as how genetic predisposition may play a role in EBV-related diseases. ..
  53. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2001
    ..These studies will address the hypothesis that the membrane skeleton of these cells is a mobile, dynamic structure. ..
  54. IN VIVO TREATMENT OF EAE WITH ANTI I-A ANTIBODIES
    Lawrence Steinman; Fiscal Year: 2001
    ..Aim 5 is to assess the possibility of using DNA vaccination against TCR Vb for treatment of EAE. It is hoped that these studies will provide the basis for future clinical trials in MS patients. ..
  55. Expressions of Specialized Collagens in the Cornea
    Marion K Gordon; Fiscal Year: 2010
    ..The alterations in fibril architecture resulting from the dominant negative phenotype will be evaluated by transmission electron microscopy. ..
  56. Emotion, communication, & EEG: Development & risk
    Daniel Messinger; Fiscal Year: 2010
    ....
  57. In Vitro Assay to Determine Skin Corrosivity Packing Groups
    Yulia Kaluzhny; Fiscal Year: 2008
    ..This project will develop an in vitro assay to determine skin corrosivity packing groups and fulfill all testing and regulatory needs. [unreadable] [unreadable] [unreadable]..
  58. GENES THAT PROMOTE ACAID AND INHIBIT OCULAR INFLAMMATION
    Sharmila Masli; Fiscal Year: 2003
    ..is characterized by anterior chamber associated immune deviation (ACAID), an unusual immune response that is eye characterized by suppressed DH induced to antigens introduced in the anterior chamber...
  59. CTLA-4 Inhibition and Autoimmunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2008
    ..abstract_text> ..
  60. Human Sensory Irritation From Volitile Organic Compounds
    William Cain; Fiscal Year: 2006
    ..F) The effect of inflammation upon chemesthetic sensitivity. G) Through measurement of the NMP, confirmation of the peripheral basis for a) temporal phenomena, b) differences in potency, and c) effects of inflammation. ..
  61. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  62. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  63. 6th International Symposium on FAP Disorders and 5th...
    Joel Buxbaum; Fiscal Year: 2006
    ..abstract_text> ..
  64. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Candidate for the study will be newly diagnosed cases with choroidal melanoma in one eye greater than 3 mm in height and up to 18 mm by 8 mm in size and with no evidence of metastatic disease who are 21 ..
  65. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  66. A New Method for Retinal Imaging
    Alan Marmorstein; Fiscal Year: 2005
    ..One form of basal deposit, basal linear deposits, are more common in AMD eyes than age-matched controls. A positive outcome to this study would warrant future clinical trials. ..