middle ear

Summary

Top Publications

  1. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
  2. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
  3. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
  4. doi Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate
    J H Ryu
    Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 166 Kumi Ro, Bundang gu, Seongnam si, Kyonggi do 463 707, Republic of Korea
    Br J Anaesth 103:490-5. 2009
  5. doi Otoendoscopy in cholesteatoma surgery of the middle ear: what benefits can be expected?
    Stephane Ayache
    ORPAC ENT Department Face and Neck Surgery Clinique du Palais, Grasse, France www orpac grasse com
    Otol Neurotol 29:1085-90. 2008
  6. doi Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
    Michael Gaihede
    Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Otol Neurotol 31:603-11. 2010
  7. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
  8. ncbi Evidence of local antibody response against Alloiococcus otitidis in the middle ear cavity of children with otitis media
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    FEMS Immunol Med Microbiol 49:41-5. 2007
  9. ncbi Characterization of a temperature-sensitive mouse middle ear epithelial cell line
    Katsuyuki Tsuchiya
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Acta Otolaryngol 125:823-9. 2005
  10. ncbi Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion
    Yasuhiro Tsuboi
    Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA
    Acta Otolaryngol 122:153-60. 2002

Detail Information

Publications301 found, 100 shown here

  1. pmc Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
    Joseph Jurcisek
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 73:3210-8. 2005
    ..NTHI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation in vivo might play an important role in the pathogenesis and chronicity of OM...
  2. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
    ..N-acetyl-neuraminic) acid promotes biofilm formation by NTHi in vitro and bacterial persistence within the middle ear or lung in vivo...
  3. pmc Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
    Jae Hyang Lim
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 2:e1032. 2007
    ..Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice...
  4. doi Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate
    J H Ryu
    Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 166 Kumi Ro, Bundang gu, Seongnam si, Kyonggi do 463 707, Republic of Korea
    Br J Anaesth 103:490-5. 2009
    This prospective, randomized study was designed to compare remifentanil and magnesium sulphate during middle ear surgery in terms of postoperative pain and other complications.
  5. doi Otoendoscopy in cholesteatoma surgery of the middle ear: what benefits can be expected?
    Stephane Ayache
    ORPAC ENT Department Face and Neck Surgery Clinique du Palais, Grasse, France www orpac grasse com
    Otol Neurotol 29:1085-90. 2008
    This study was conducted with the aim of determining the contribution of otoendoscopy in the surgical management of cholesteatoma of the middle ear.
  6. doi Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
    Michael Gaihede
    Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Otol Neurotol 31:603-11. 2010
    b>Middle ear pressure (MEP) is actively regulated by both the Eustachian tube and the mastoid air cell system.
  7. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
    Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains...
  8. ncbi Evidence of local antibody response against Alloiococcus otitidis in the middle ear cavity of children with otitis media
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    FEMS Immunol Med Microbiol 49:41-5. 2007
    ..otitidis has a pathogenic role and induces local immune response in the middle ear as a true pathogen. Whole bacterial sonicate of A...
  9. ncbi Characterization of a temperature-sensitive mouse middle ear epithelial cell line
    Katsuyuki Tsuchiya
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Acta Otolaryngol 125:823-9. 2005
    Temperature-sensitive mouse middle ear epithelial cells have been successfully established and characterized.
  10. ncbi Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion
    Yasuhiro Tsuboi
    Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA
    Acta Otolaryngol 122:153-60. 2002
    Otitis media with mucoid effusion, characterized by mucous cell metaplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a common otological disease that frequently affects young children...
  11. doi Evolutionary development of the middle ear in Mesozoic therian mammals
    Qiang Ji
    Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China
    Science 326:278-81. 2009
    The definitive mammalian middle ear (DMME) is defined by the loss of embryonic Meckel's cartilage and disconnection of the middle ear from the mandible in adults...
  12. ncbi High frequency of Alloiococcus otitidis in the nasopharynx and in the middle ear cavity of otitis-prone children
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Pediatr Otorhinolaryngol 70:1009-14. 2006
    Colonization of middle ear pathogens is facilitated in the nasopharynx of otitis-prone children, and is associated with the development of otitis media...
  13. ncbi Tetrapod-like middle ear architecture in a Devonian fish
    Martin D Brazeau
    Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
    Nature 439:318-21. 2006
    ..in the remodelling of the spiracular tract and suspensorium (jaw suspension) of osteolepiform fishes into the middle ear of tetrapods have remained elusive...
  14. ncbi Demonstration of nasopharyngeal and middle ear mucosal biofilms in an animal model of acute otitis media
    Michael Hoa
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Otol Rhinol Laryngol 118:292-8. 2009
    We performed this study to determine the role of nasopharyngeal and middle ear (ME) biofilms in acute otitis media (AOM).
  15. ncbi Randomized, double-blind, placebo-controlled, dosed-finding study of the antiemetic effects and tolerability of ramosetron in adults undergoing middle ear surgery
    Yoshitaka Fujii
    Department of Anesthesiology, Toride Kyodo General Hospital, Toride, Japan
    Clin Ther 25:3100-8. 2003
    ..another SSRA, in preventing emetic symptoms in adults in the first 48 hours after the start of anesthesia for middle ear surgery...
  16. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
    ..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear.
  17. pmc Hag directly mediates the adherence of Moraxella catarrhalis to human middle ear cells
    Brian Bullard
    Department of Medical Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave, Health Education Bldg, Rm 267, Toledo, OH 43614, USA
    Infect Immun 73:5127-36. 2005
    ..with a spectinomycin resistance cassette, and the binding of isogenic mutants to primary cultures of human middle ear epithelial cells (HMEE), as well as A549 pneumocytes, was measured...
  18. pmc Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media
    Masayuki Furukawa
    Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA
    Infect Immun 75:2562-71. 2007
    ..the participation of signaling via the Jun N-terminal protein kinase (JNK) mitogen-activated protein kinase in middle ear mucosal hyperplasia in animal models of bacterial otitis media...
  19. ncbi Prophylactic antiemetic effect of midazolam after middle ear surgery
    Jae Sik Jung
    Department of Anesthesiology, Kyungpook National University Hospital, Jung Gu, Daegu, Republic of Korea
    Otolaryngol Head Neck Surg 137:753-6. 2007
    To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
  20. ncbi Middle ear and cochlear disorders result in different DPOAE growth behaviour: implications for the differentiation of sound conductive and cochlear hearing loss
    Daniel D Gehr
    ENT Department, Technische Universitat Munchen, Clinic rechts der Isar, Ismaninger Strasse 22, D 81675 Munich, Germany
    Hear Res 193:9-19. 2004
    ..With an inner ear dysfunction a steeper I/O-function is observed. Due to the linear sound processing of the middle ear, one can assume that the DPOAE growth behaviour remains unaltered with a sound conduction dysfunction...
  21. pmc Clinically applicable multiplex PCR for four middle ear pathogens
    P H Hendolin
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Clin Microbiol 38:125-32. 2000
    ..H. Hendolin, A. Markkanen, J. Ylikoski, and J. J. Wahlfors, J. Clin. Microbiol. 35:2854-2858, 1997) in middle ear effusions (MEEs) was modified to be better suited for clinical use...
  22. doi Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Int J Pediatr Otorhinolaryngol 73:677-80. 2009
    ..In the middle ear, proinflammatory cytokines and chemokines are released in association with infection by pathogens, and these ..
  23. ncbi Modeling of the human middle ear using the finite-element method
    Takuji Koike
    Department of Mechanical Engineering, Tohoku University, Sendai, Japan
    J Acoust Soc Am 111:1306-17. 2002
    In this study, a three-dimensional finite-element model (FEM) of the human middle ear was established, including features of the middle ear which were not considered in the previous model, i.e...
  24. ncbi Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution
    Abigail S Tucker
    Department of Craniofacial Development and Orthodontics, Kings College London, Floor 28, Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Development 131:1235-45. 2004
    The middle ear apparatus is composed of three endochondrial ossicles (the stapes, incus and malleus) and two membranous bones, the tympanic ring and the gonium, which act as structural components to anchor the ossicles to the skull...
  25. doi TORP-vibroplasty: a new alternative for the chronically disabled middle ear
    Karl Bernd Huttenbrink
    Department of Otorhinolaryngology Head and Neck Surgery, University Clinic, Cologne, Germany
    Otol Neurotol 29:965-71. 2008
    Surgery can often eradicate chronic middle ear disease in patients with recurrent cholesteatoma, tubal dysfunction, and others; however, in many cases, social hearing cannot be restored even after multiple revision tympanoplasties...
  26. ncbi Congenital malformations of the external and middle ear
    S Kösling
    Department of Diagnostic Radiology, University of Halle, Germany
    Eur J Radiol 69:269-79. 2009
    ..fields, which are necessary to know for a profound understanding of congenital malformations of the external and middle ear. Typical and less typical combinations of malformed parts of the ear can be derived from the embryogenesis...
  27. ncbi High-resolution imaging of the middle ear with optical coherence tomography: a feasibility study
    C Pitris
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 50 Vassar St, Room 36-345, Cambridge, MA 02139, USA
    Arch Otolaryngol Head Neck Surg 127:637-42. 2001
    ..OBJECTIVE: To demonstrate the feasibility of using OCT for ultra-high-resolution imaging of the middle ear via ex vivo imaging studies of human tissue...
  28. doi Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001
    Anders Rørbaek Madsen
    Odense University Hospital, Sdr Boulevard 29, Odense, Denmark
    Head Neck 30:1332-8. 2008
    ..In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival...
  29. ncbi Evaluation of middle ear function in young children: clinical guidelines for the use of 226- and 1,000-Hz tympanometry
    Jane Alaerts
    ExpORL, Department Neurosciences, K U Leuven, Leuven, Belgium
    Otol Neurotol 28:727-32. 2007
    ..The aims of the study were to evaluate tympanometry with regard to age and classification system using two probe-tone frequencies and to provide clinical guidelines...
  30. pmc Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media
    Sean D Palacios
    Department of Surgery Otolaryngology, University of California San Diego, La Jolla, 92037, USA
    Infect Immun 72:4662-7. 2004
    Hyperplasia of the middle ear mucosa contributes to the sequelae of acute otitis media...
  31. ncbi IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion
    Manabu Nonaka
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 123:383-7. 2003
    The purpose of this study was to evaluate eosinophil infiltration as well as IL-5 and eotaxin levels in middle ear effusion (MEE) and blood from otitis media with effusion (OME) patients with asthma and to compare the findings with those ..
  32. doi Evaluation of implantable actuators by means of a middle ear simulation model
    Matthias Bornitz
    Department of Medicine, Technische Universitat Dresden, Germany
    Hear Res 263:145-51. 2010
    ..now a great variety of devices available with different actuator concepts and different attachment points to the middle ear or inner ear fluid...
  33. ncbi A comparison of total intravenous with balanced anaesthesia for middle ear surgery: effects on postoperative nausea and vomiting, pain, and conditions of surgery
    K Mukherjee
    Medway Maritime Hospital, Gillingham, UK
    Anaesthesia 58:176-80. 2003
    We compared postoperative nausea and vomiting (PONV), pain and conditions for surgery in patients scheduled for middle ear surgery...
  34. ncbi Remifentanil induces consistent and sustained controlled hypotension in children during middle ear surgery
    Christian S Degoute
    Department of Anesthesiology, Centre Hospitalo Universitaire Lyon Sud, France
    Can J Anaesth 50:270-6. 2003
    To determine in children whether remifentanil combined with sevoflurane, could induce controlled hypotension, reduce middle ear blood flow (MEBF) measured by laser-Doppler, and provide a satisfactory operative field.
  35. ncbi Interleukin-1beta upregulates Na+-K+-2Cl- cotransporter in human middle ear epithelia
    Su Jin Kim
    The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Korea
    J Cell Biochem 101:576-86. 2007
    ..suggested that the altered functions of ion channels and transporters are involved in the fluid collection of middle ear cavity of OME patients...
  36. ncbi Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1
    Y Mallet
    Departments of Otorhinolaryngology, centre hospitalier universitaire Lille, Lille, France
    Laryngoscope 113:328-31. 2003
    ..To assess an easy method that predicts cholesteatoma aggressiveness...
  37. ncbi Taste function after section of chorda tympani nerve in middle ear surgery
    Tomomi Nin
    Department of Otolaryngology, Hyogo College of Medicine, Mukogawa, Nishinomiya City, Hyogo 663 8501, Japan
    Auris Nasus Larynx 33:13-7. 2006
    To investigate prospectively the clinical manifestations and the functional recovery of taste after section of chorda tympani nerve (CTN) during middle ear surgery, the subjective and objective study on the patients was performed.
  38. ncbi Interleukin-1beta suppresses epithelial sodium channel beta-subunit expression and ENaC-dependent fluid absorption in human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Eur J Pharmacol 567:19-25. 2007
    ..In this study, we investigated the role of epithelial sodium channel (ENaC) in fluid absorption in normal human middle ear epithelial (NHMEE) cells, as well as the effects of Interleukin (IL)-1beta on ENaC expression and fluid ..
  39. ncbi Neuro-endocrine adenoma of the middle ear: a case study
    D Bakhos
    Department of ENT, Head and Neck Surgery, CHRU Bretonneau, 2 boulevard Tonnelle, 37044, Tours, France
    Eur Arch Otorhinolaryngol 264:1525-8. 2007
    Neuroendocrine adenomas are rare tumors, which can appear in the middle ear. Approximately a hundred cases have been reported in the literature...
  40. ncbi Middle ear adenoma
    Stephen Berns
    Orlando Regional Healthcare System Department of Pathology M D Anderson Cancer Center, Orlando, Florida 32806, USA
    Arch Pathol Lab Med 130:1067-9. 2006
    b>Middle ear adenoma is a benign tumor of the middle ear that can have exocrine (mucinous) and/or neuroendocrine differentiation...
  41. ncbi The effect of dexmedetomidine on middle ear pressure
    Yezdan Firat
    Department of Otorhinolaryngology, Inonu University, Malatya, Turkey
    Otolaryngol Head Neck Surg 137:218-23. 2007
    ..The aim of this study was to evaluate the influence of this novel agent on middle ear pressure.
  42. pmc Developmental changes in word recognition threshold from two to five years of age in children with different middle ear status
    Amanda J Hall
    Centre for Hearing and Balance Studies, University of Bristol, UK
    Int J Audiol 46:355-61. 2007
    ..However by 61 months, previous OME status was not significant. To our knowledge, this is the largest longitudinal study reporting WRT in preschool children with different middle ear status.
  43. ncbi Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
    Sung Kyun Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Biochim Biophys Acta 1590:41-51. 2002
    ..the presence of molecules of innate immunity such as lysozyme and lactoferrin has been demonstrated in the middle ear, to date there have been no reports on the expression of beta-defensin 2...
  44. ncbi In vivo demonstration of the absorptive function of the middle ear epithelium
    Ji ping Li
    Otolaryngology Head Neck Surgery Department, Ren Ji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Hear Res 210:1-8. 2005
    The present study investigated in vivo fluid and ion transport across the middle ear epithelium. The tympanic membrane of rats was punctured under general anesthesia...
  45. ncbi Growth factors influence growth and differentiation of the middle ear mucosa
    S D Palacios
    Department of Head and Neck Surgery, University of California-San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Laryngoscope 111:874-80. 2001
    ..of this study to determine which growth factors might be responsible for the growth and differentiation of the middle ear epithelium during otitis media...
  46. doi Activation of epithelial sodium channel in human middle ear epithelial cells by dexamethasone
    Eun Jin Son
    Department of Otorhinolaryngology, National Medical Center, Seoul, South Korea
    Eur J Pharmacol 602:383-7. 2009
    The middle ear epithelium functions to maintain a fluid-free middle ear cavity...
  47. ncbi Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
    M Mallo
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Development 127:4127-36. 2000
    ..Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes...
  48. ncbi Environmental tobacco smoke and middle ear disease in preschool-age children
    C E Adair-Bischoff
    Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Alberta
    Arch Pediatr Adolesc Med 152:127-33. 1998
    To determine the association between environmental tobacco smoke and middle ear disease in pre-school age children.
  49. ncbi [The relevance of Choukroun's Platelet-Rich Fibrin (PRF) during middle ear surgery: preliminary results]
    F Braccini
    Institut Azuréen d ORL et de Chirurgie de la Face, 25 Avenue Jean Médecin, F 06000 Nice, France
    Rev Laryngol Otol Rhinol (Bord) 130:175-80. 2009
    ..To evaluate the relevance of Leucocyte- and Platelet-Rich Fibrin (L-PRF, Choukroun's technique) Concentrates during tympanoplasty...
  50. pmc Analysis of chick (Gallus gallus) middle ear columella formation
    Jamie L Wood
    Clemson University, Biological Sciences, Long Hall, Clemson, SC 29634, USA
    BMC Dev Biol 10:16. 2010
    The chick middle ear bone, the columella, provides an accessible model in which to study the tissue and molecular interactions necessary for induction and patterning of the columella, as well as associated multiple aspects of endochondral ..
  51. doi Histologic analysis of the effects of three different support materials within rat middle ear
    Salim Dogru
    Department of Otolaryngology, Haydarpasa Training Hospital, Istanbul, Turkey
    Otolaryngol Head Neck Surg 140:177-82. 2009
    To investigate histologic changes in the mucosa of rat middle ear after implantation of three different support materials.
  52. doi Middle ear cancer: a population-based study
    Richard K Gurgel
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
    Laryngoscope 119:1913-7. 2009
    Primary carcinoma of the middle ear is a rare clinical entity, best suited for evaluation using a population-based database...
  53. pmc Steroid control of acute middle ear inflammation in a mouse model
    Carol J Macarthur
    Department of Otolaryngology Head and Neck Surgery and Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arch Otolaryngol Head Neck Surg 135:453-7. 2009
    ..Glucocorticoids and mineralocorticoids have differential effects on inflammation and fluid absorption, but little is known of their control of middle and inner ear manifestations of acute otitis media...
  54. doi Defects in middle ear cavitation cause conductive hearing loss in the Tcof1 mutant mouse
    Carol A Richter
    Department of Craniofacial Development, Dental Institute, King s College London, London SE1 9RT, UK
    Hum Mol Genet 19:1551-60. 2010
    ..of the mechanisms underlying CHL remains, particularly with respect to the molecular mechanisms underlying middle ear development and disease...
  55. ncbi Adenoma in the middle ear: a report of two cases
    S E Jones
    Department of ENT Surgery, Ipswich Hospital, Ipswich, UK
    J Laryngol Otol 115:216-9. 2001
    ..We discuss the pathology of middle-ear adenoma, its diagnosis and treatment, and suggest ways of improving its management...
  56. ncbi Otologics Middle Ear Transducer Ossicular Stimulator: performance results with varying degrees of sensorineural hearing loss
    Herman A Jenkins
    University of Colorado Health Sciences Center, Denver, CO 80202, USA
    Acta Otolaryngol 124:391-4. 2004
    This study was conducted to demonstrate the safety and efficacy of the Otologics Middle Ear Transducer (MET) Ossicular Stimulator and, in particular, to compare the audiologic benefits of this novel form of electromechanical stimulation ..
  57. pmc Mucin gene 19 (MUC19) expression and response to inflammatory cytokines in middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI, 53226, USA
    Glycoconj J 26:1275-84. 2009
    Mucin gene 19 (MUC19) has been identified as a major gel-forming mucin in the human middle ear (ME)...
  58. ncbi Surgical anatomy of the rat middle ear
    R F Judkins
    Department of Otolaryngology Head and Neck Surgery, Medical College of Ohio, Toledo 43699 0008, USA
    Otolaryngol Head Neck Surg 117:438-47. 1997
    This study was designed to aid experimental otologic studies of the rat middle ear. The topographic anatomy of the albino rat middle ear is described...
  59. doi Totally implantable active middle ear implants: ten years' experience at the University of Tübingen
    H P Zenner
    Department of Otolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    Adv Otorhinolaryngol 69:72-84. 2010
    Active middle ear implants do not produce acoustic sounds but, rather, micromechanical vibrations...
  60. pmc Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants
    H H Tong
    Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
    Infect Immun 69:3678-84. 2001
    ..compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cell cytokine and chemokine gene expression and production in vitro...
  61. pmc MUC5AC expression in human middle ear epithelium of patients with otitis media
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Otolaryngol Head Neck Surg 136:819-24. 2010
    To compare levels of middle ear (ME) MUC5AC expression in patients with otitis media (OM) with patients without OM...
  62. ncbi Ventral approach to the rat middle ear for otologic research
    M Pinilla
    Department of Otorhinolaryngology, Clinica Puerta de Hierro, Universidad Autonoma, Madrid, Spain
    Otolaryngol Head Neck Surg 124:515-7. 2001
    To describe a simple approach to the rat middle ear because there are few clear descriptions of this technique with minimal morbidity and mortality.
  63. doi Active middle ear implant application in case of stapes fixation: a temporal bone study
    Arnaud Deveze
    Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, U S A
    Otol Neurotol 31:1027-34. 2010
    Driving the oval window directly with an active middle ear implant (AMEI) can produce high levels of input to the inner ear.
  64. ncbi Prevention of PONV by acustimulation with capsicum plaster is comparable to ondansetron after middle ear surgery
    Mahender Nath Misra
    Department of Anesthesiology, MLN Medical College and Associated Hospitals, Allahabad, India
    Can J Anaesth 52:485-9. 2005
    ..To compare the efficacy of stimulation of P6 acupoint with capsicum plaster in comparison with iv ondansetron for the prevention of postoperative nausea and vomiting (PONV)...
  65. ncbi Cochlear effects of mesna application into the middle ear
    V Vincenti
    E N T Clinic, University of Parma, Italy
    Ann N Y Acad Sci 884:425-32. 1999
    ..The aim of this study was to evaluate the toxicity of mesna application into the middle ear on the cochlear anatomy and physiology. Three groups of guinea pigs were used as subjects...
  66. pmc Mucin gene expression and mouse middle ear epithelium
    Joseph E Kerschner
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, United States
    Int J Pediatr Otorhinolaryngol 74:864-8. 2010
    To investigate the expression of recently identified human mucin genes in an in vitro model of cultured mouse middle ear epithelial cells (MMEEC).
  67. ncbi MRI and CT of adenomatous tumours of the middle ear
    D Maintz
    Department of Diagnostic Radiology, University of Cologne Medical School, Germany
    Neuroradiology 43:58-61. 2001
    ..All showed contrast enhancement and similar signal intensity as brain tissue on T1- and T2-weighted images. The biological nature of the tumours was not reflected by the imaging or operative findings...
  68. pmc Comparison of in-situ calibration methods for quantifying input to the middle ear
    James D Lewis
    Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
    J Acoust Soc Am 126:3114-24. 2009
    ..FPL and IPL were both investigated as measures of sound-level entering the middle ear. FPL may be a better measure of middle-ear input because IPL is more dependent on middle-ear reflectance and ear-..
  69. ncbi Magnetic resonance imaging of the mastoid cavity and middle ear: prevalence and clinical significance of incidental abnormal findings in a nonotolaryngologic adult and pediatric population
    Dong Hee Lee
    Department of Otolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Otolaryngol 35:13-8. 2006
    The purposes of this study were to determine the prevalence of abnormalities in the mastoid cavity and middle ear in a nonotolaryngologic population and to correlate the results with clinical data.
  70. doi Middle ear and mastoid glomus tumors (glomus tympanicum): an algorithm for the surgical management
    Mario Sanna
    Gruppo Otologico, Piacenza Rome, Italy
    Auris Nasus Larynx 37:661-8. 2010
    Glomus tumors are slow-growing benign lesions and represent the most common primary neoplasms of the middle ear. The objective of the present study is to report our surgical strategy in the management of glomus tympanicum tumors.
  71. ncbi Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear
    Ming Yang Lee
    Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center, Tainan, Taiwan
    J Craniofac Surg 17:797-800. 2006
    ..GCT of the right petrous temporal bone extending into the contiguous middle cranial fossa, infratemporal space, middle ear and external ear canal...
  72. ncbi Changes of oral trigeminal sensitivity in patients after middle ear surgery
    Tino Just
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, Germany
    Laryngoscope 117:1636-40. 2007
    ..The specific aim of this study was to re-investigate the effect of chorda tympani damage on both trigeminal sensitivity and taste ability...
  73. ncbi Facial canal anatomy in patients with mandibulofacial dysostosis: comparison with respect to the severities of microtia and middle ear deformity
    Hideki Takegoshi
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Otol Neurotol 26:803-8. 2005
    To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with mandibulofacial dysostosis using high-resolution computed tomography.
  74. doi Antiemetic efficacy of dexamethasone combined with midazolam after middle ear surgery
    Jinseok Yeo
    Department of Anesthesiology, Kyungpook National University Hospital, Daegue, Republic of Korea
    Otolaryngol Head Neck Surg 141:684-8. 2009
    To evaluate the antiemetic efficacy of dexamethasone combined with midazolam after middle ear surgery.
  75. ncbi Multiple osteomas in the middle ear
    Chang Woo Kim
    Department of Otorhinolaryngology Head and Neck Surgery, Hallym University College of Medicine, 445 Gil Dong, Gangdong gu, Seoul 134 701, Korea
    Eur Arch Otorhinolaryngol 263:1151-4. 2006
    Osteomas in the middle ear are extremely rare and are generally solitary and small...
  76. ncbi On the physics of the infant feeding bottle and middle ear sequela: ear disease in infants can be associated with bottle feeding
    C E Brown
    Mt Zion Family Care Center, Southern Illinois University School of Medicine, 1200 North State Highway 121, Mt Zion, IL 62549 USA
    Int J Pediatr Otorhinolaryngol 54:13-20. 2000
    ..The negative pressure inside the bottle causes the infant to suck excessively and the intraoral negative pressure may subsequently be transmitted to the middle ear via the eustachian tube.
  77. pmc Partial characterization of normal and Haemophilus influenzae-infected mucosal complementary DNA libraries in chinchilla middle ear mucosa
    Joseph E Kerschner
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Ann Otol Rhinol Laryngol 119:270-8. 2010
    We sought to construct and partially characterize complementary DNA (cDNA) libraries prepared from the middle ear mucosa (MEM) of chinchillas to better understand pathogenic aspects of infection and inflammation, particularly with respect ..
  78. ncbi Detection of mucin gene expression in normal rat middle ear mucosa by reverse transcriptase-polymerase chain reaction
    Y P Chen
    Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210-1282, USA
    Acta Otolaryngol 121:45-51. 2001
    ..The mechanisms controlling mucin secretion in the middle ear are not completely understood...
  79. ncbi Computer-integrated finite element modeling of human middle ear
    Q Sun
    School of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK 73019, USA
    Biomech Model Mechanobiol 1:109-22. 2002
    The objective of this study was to produce an improved finite element (FE) model of the human middle ear and to compare the model with human data...
  80. ncbi Role of transtympanic endoscopy of the middle ear in the diagnosis of perilymphatic fistula in patients with sensorineural hearing loss or vertigo
    Z Selmani
    Department of Otolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    ORL J Otorhinolaryngol Relat Spec 64:301-6. 2002
    The diagnosis of perilymphatic fistula (PLF) is often difficult, and therefore the condition can be overlooked. Tympanoscopy presents an alternative procedure for visualising the middle ear anatomy, and it may help to diagnose PLF.
  81. ncbi Virtual CT otoscopy of the middle ear and ossicles in dogs
    Kidong Eom
    College of Veterinary Medicine, Konkuk University, Veterinary Diagnostic Imaging
    Vet Radiol Ultrasound 49:545-50. 2008
    Virtual otoscopy enables noninvasive 3D endoluminal imaging of the middle ear through postprocessing of computed tompgraphy (CT) data...
  82. ncbi Minimally invasive, image-guided, facial-recess approach to the middle ear: demonstration of the concept of percutaneous cochlear access in vitro
    Robert F Labadie
    Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8605, USA
    Otol Neurotol 26:557-62. 2005
    Image-guided surgery will permit accurate access to the middle ear via the facial recess using a single drill hole from the lateral aspect of the mastoid cortex.
  83. ncbi Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wakayama, Japan
    ORL J Otorhinolaryngol Relat Spec 66:233-40. 2004
    ..isolates of Streptococcus pneumoniae and 30 isolates of Haemophilus influenzae from paired nasopharynx and middle ear fluids of 21 children with acute otitis media (AOM) were evaluated to determine genotypes by polymerase chain ..
  84. ncbi Retinoic acid disturbs mouse middle ear development in a stage-dependent fashion
    M Mallo
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Biol 184:175-86. 1997
    The mammalian middle ear contains a chain of three ossicles, the malleus, incus, and stapes, that transmit into the inner ear the vibrations produced in the tympanic membrane by aerial sound...
  85. doi Middle ear structure and bone conduction in Spalax, Eospalax, and Tachyoryctes mole-rats (Rodentia: Spalacidae)
    Matthew J Mason
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Morphol 271:462-72. 2010
    ....
  86. ncbi Virtual endoscopy of the middle ear: experimental and clinical results of a standardised approach using multi-slice helical computed tomography
    Thomas Rodt
    Department of Neuroradiology, Medical School Hannover, Carl Neuberg Strasse 1, Germany
    Eur Radiol 12:1684-92. 2002
    Virtual endoscopy (VE) enables non-invasive 3D endoluminal imaging of the middle ear by post-processing of CT data. To optimise the clinical application a standardised approach was evaluated in normal and pathologic cases...
  87. ncbi The human anterior tympanic artery. A nutrient artery of the middle ear with highly variable origin
    R Wasicky
    Department 2, Institute of Anatomy, University of Vienna, Austria
    Cells Tissues Organs 166:388-94. 2000
    ..the deep auricular, middle, and accessory meningeal, as well as the posterior deep temporal, inferior alveolar and masseteric arteries were found to form common trunks with the anterior tympanic artery...
  88. ncbi ENaC- and CFTR-dependent ion and fluid transport in human middle ear epithelial cells
    Jae Young Choi
    Department of Otorhinolaryngology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu Seoul, 120 752, Republic of Korea
    Hear Res 211:26-32. 2006
    Ion channels, such as the epithelial sodium channel (ENaC), are essential for maintaining a fluid-free middle ear cavity by controlling periciliary fluid...
  89. ncbi Selective expression of aquaporin 1, 4 and 5 in the rat middle ear
    S Minami
    Department of Pharmacology, Miyazaki Medical College, Kiyotake, Japan
    Hear Res 158:51-6. 2001
    The middle ear cavity is an air-filled space that must be maintained for effective sound transmission to the inner ear...
  90. ncbi Acoustic responses of the human middle ear
    S E Voss
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 150:43-69. 2000
    Measurements on human cadaver ears are reported that describe sound transmission through the middle ear. Four response variables were measured with acoustic stimulation at the tympanic membrane: stapes velocity, middle-ear cavity sound ..
  91. ncbi In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation
    Kota Wada
    Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 126:801-10. 2006
    These experimental findings suggest the feasibility of artificial middle ear mucosa grafting as an effective treatment for achieving mucosal regeneration after middle ear surgery.
  92. ncbi Difference in facial canal anatomy in terms of severity of microtia and deformity of middle ear in patients with microtia
    Hideki Takegoshi
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Laryngoscope 113:635-9. 2003
    To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with microtia using high-resolution computed tomography (HRCT).
  93. ncbi Squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin
    Takashi Nakagawa
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Otol Neurotol 27:242-8; discussion 249. 2006
    ..Treatment outcomes for squamous cell carcinoma of the temporal bone were evaluated regarding stage, therapeutic strategy, and prognostic factors...
  94. ncbi Virtual endoscopy imaging of the middle ear cavity and ossicles
    T S Karhuketo
    Department of Otorhinolaryngology, Tampere University Hospital, Finland
    Eur Arch Otorhinolaryngol 259:77-83. 2002
    ..Virtual endoscopic images were produced with separate, commercially available software, paying attention to the middle ear cavity and ossicles...
  95. pmc The mastoid as a functional rate-limiter of middle ear pressure change
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, 3000 Mt Royal Blvd, Glenshaw, PA 15116, USA
    Int J Pediatr Otorhinolaryngol 71:393-402. 2007
    The physiological function of the mastoid air cell system (MACS) with respect to middle ear (ME) pressure-regulation remains controversial because predictive mathematical models and experimental data to formulate and test hypotheses are ..
  96. ncbi Measurements of human middle ear forward and reverse acoustics: implications for otoacoustic emissions
    Sunil Puria
    Stanford University, Mechanics and Computation Division, Palo Alto, California 94305, USA
    J Acoust Soc Am 113:2773-89. 2003
    ..These measurements can be used to fully characterize the middle ear as a two-port system...
  97. ncbi Signaling pathways in interleukin-1beta-mediated middle ear mucin secretion
    Joseph E Kerschner
    Division of Pediatric Otolaryngology and the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Laryngoscope 116:207-11. 2006
    ..protein kinase C (PKC), and nitric oxide synthase (NOS) pathways during upregulation of mucin secretion by middle ear epithelium after exposure to interleukin-1beta and to examine the ability of a specific interleukin-1 receptor ..
  98. doi Middle ear impedance measurements in large vestibular aqueduct syndrome
    Cem Bilgen
    Ege University, Medical School, Department of Otorhinolaryngology, Izmir, Turkey
    Auris Nasus Larynx 36:263-8. 2009
    To assess the effect of inner ear pressure on middle ear impedance in patients with large vestibular aqueduct syndrome (LVAS).
  99. ncbi Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma
    Y Iino
    Department of Otolaryngology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Exp Allergy 31:1135-43. 2001
    ..with intractable otitis media associated with bronchial asthma have extensive accumulation of eosinophils in the middle ear mucosa and middle ear effusion, systematic histological and immunohistochemical studies have not been performed.
  100. doi The prevalence and significance of incidental middle ear and mastoid cavity abnormalities on MRI in a pediatric population
    Ali Balci
    Mustafa Kemal University, Faculty of Medicine, Department of Radiology, Antakya 31100, Hatay, Turkey
    Int J Pediatr Otorhinolaryngol 72:1849-54. 2008
    The purposes of this study were to determine the prevalence of abnormalities in the middle ear and mastoid cavity on the magnetic resonance imaging (MRI) in children and correlate the results with clinical data, tympanometric findings and ..
  101. ncbi Current use of implants in middle ear surgery
    R A Goldenberg
    Department of Otolaryngology, Wright State University School of Medicine, Dayton, Ohio, USA
    Otol Neurotol 22:145-52. 2001
    ..Of the 575 questionnaires mailed, 274 (47%) were returned. Only 248 of the respondents performed middle ear surgery (43%), and their responses constitute the database for this study...

Research Grants68

  1. HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSION
    Sunil Puria; Fiscal Year: 2002
    This project seeks to characterize forward and reverse sound transmission through the human middle ear. One of the most significant discoveries in hearing during the past twenty years has been that a healthy ear not only detects sound but ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  3. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Aim 4: Determine if effective inner ear homeostatic and anti-inflammatory gene expression can be induced by middle ear steroid delivery...
  4. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..that contributes to chronic upper respiratory disorders, including chronic sinusitis, allergic rhinitis, middle ear disease, as well as pulmonary disease that contribute to respiratory morbidity and mortality world wide...
  5. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The middle ear plays a vital role in the sense and sensitivity of hearing, yet there is currently a lack of knowledge about the mechanisms of high-frequency middle-ear sound transmission in mammals...
  6. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    ..The research also evaluates whether the test battery improves the accuracy of diagnosing middle-ear disease and of identifying hearing loss in adult patients who receive medications that may affect their hearing. ..
  7. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..applicant): It has become evident that innate immunity plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  8. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..causes infection by inhabiting environmental niches contiguous with the upper respiratory tract, including the middle ear space (otitis media) and the airways in adults with COPD...
  9. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..As a pathogen, it spreads to the lungs (pneumonia), the central nervous system (meningitis), and the middle ear (otitis media). Mortality and morbidity due to S. pneumoniae is seen primarily in the very young and elderly...
  10. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    ..Mucosal inflammation and disease derived from pneumococcal infections are caused by high bacterial burden in the middle ear and other organs. Successful growth of S...
  11. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..is often refractory to treatment and inflicts significant morbidity in the form of hearing loss and long-term middle ear dysfunction...
  12. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..long-term goal of this research program is to identify and prevent the inflammatory processes by which chronic middle ear disease causes permanent cochlear damage...
  13. CLONING OF THE Hol MUTATION
    Licia Selleri; Fiscal Year: 2009
    ..Additionally, 04/014 mutants exhibit low-set and hypoplastic ear pinnae and their middle ear ossicles are severely affected...
  14. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..Following each episode of acute otitis media, fluid remains in the middle ear for weeks to months and is associated with significant hearing deficit, a sequela that in turn can impair ..
  15. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..SHSe) in children compromises pulmonary function and contributes to respiratory illness, wheeze, cough, asthma, middle ear disease, and sudden infant death syndrome...
  16. 3D Single Fiber Endoscope for Minimally Invasive Surgeries
    Jason Geng; Fiscal Year: 2013
    ..3D surface imaging capability for minimally invasive surgeries, such as otolaryngology surgeries (access sinus, middle ear, inner ear and skull based surgeries), and eye surgeries and drug placement on optic nerves...
  17. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM), or middle ear infection, is a highly prevalent pediatric disease worldwide, ranking first in reasons why children make physician's office and emergency room visits, undergo ..
  18. The Role of Eya4 in Hearing and Disease
    Jonathan G Seidman; Fiscal Year: 2010
    ..In addition, Eya4-/- mice uniformly develop middle ear effusions and purulent otitis media by 6 weeks of age;neither occurs in wildtype or Eya4+/- mice...
  19. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE:Otitis media, or middle ear infection, is a major public health problem in young children both in the US and in the world...
  20. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..will focus on two increasingly prevalent diseases encountered in the primary care office, namely otitis media (middle ear infections) and diabetic retinopathy...
  21. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..b>Middle ear diseases, such as chronic otitis media and otosclerosis, which affect over 30 million people in the U.S...
  22. CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA
    RICHARD ARTHUR CHOLE; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Aural cholesteatomas are epithelial cyst-like structures occurring in the middle ear as a complication of otitis media and when infected they are aggressive, recurrent and recalcitrant to treatment...
  23. Genetics &Biology of M. catarrhalis LOS in Otitis Media
    Anthony A Campagnari; Fiscal Year: 2013
    Moraxella catarrhalis is a Gram-negative human mucosal pathogen, a significant cause of middle ear infections and sinusitis in infants and children and an important source of exacerbations in adults with lung disease...
  24. H. influenzae Genes Associated with Acute Otitis Media
    Janet R Gilsdorf; Fiscal Year: 2010
    ..ears of children with otitis media appear to possess specific genes offering increased bacterial fitness in the middle ear that are not required for NTHi colonization of the pharynx, we will use prevalence analysis, as performed on a ..
  25. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..of age and repeat bilateral VT insertions post-palatoplasty to study end as dictated by an algorithm based on middle ear (ME) status...
  26. Effect of the Middle Ear Inflammation On the Inner Ear
    STEVEN SUNG KYUN JUHN; Fiscal Year: 2013
    ..The disease can lead to middle ear and inner ear pathology and hearing loss...
  27. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..We will determine the level of NP and middle ear up-regulation of NTHi/Spn epithelial adherence receptors during antecedent respiratory viral infections;define ..
  28. Validation of a Genomic Biomarker of Response to Environmental Tobacco Smoke
    AVRUM E SPIRA; Fiscal Year: 2012
    ..source of childhood morbidity;resulting in lower respiratory illnesses;cough, phlegm, wheeze, and breathlessness;middle ear disease;and a lower level of lung function...
  29. Avian Middle Ear Development
    SUSAN CAROLINE CHAPMAN; Fiscal Year: 2012
    ..and molecular mechanism underlying induction, patterning and cell fate specification in the vertebrate middle ear. This study examines the tissue interactions and functional mechanisms involved in induction and morphogenesis ..
  30. CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUM
    Joseph E Kerschner; Fiscal Year: 2013
    ..Specifically, gel-forming mucins (GFM), produced by middle ear mucosa (MEM), are known to be the primary cause of hearing loss which develops in children with chronic OM and ..
  31. Molecular roles in active and passive mechanics in cochlear hair bundles
    ANTHONY WEI PENG; Fiscal Year: 2013
    ..Sound vibrations enter the outer ear through the ear canal and are converted into pressure waves by the middle ear. Pressure waves in the inner ear are converted to an electrical signal via the mechano-electrical transduction (..
  32. Novel Methods to Reduce Children's Secondhand Smoke Exposure
    THEODORE LEE WAGENER; Fiscal Year: 2013
    ..The results from this study will help determine the effects and feasibility of using spit-less, non-combustible nicotine-containing products by caregivers as a method of reducing children's SHSe. ..
  33. Regulation of Inflammation by EGFR in Otitis Media
    Xiangbin Xu; Fiscal Year: 2012
    ..Inflammation in the middle ear caused by microorganisms is a hallmark of OM...
  34. Ossicle vibration measurements in conductive hearing loss
    Steven L Jacques; Fiscal Year: 2013
    ..based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to [unreadable]m amplitude...
  35. Biomechanical Measurement and Modeling of Normal and Diseased Middle Ears
    Rong Z Gan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The middle ear, composed of ossicles and soft tissues including the tympanic membrane, ligaments, and joints plays a vital role in the transmission of sound and the sense of hearing...
  36. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2013
    ..prosthesis, an intratympanic bisphosphonate formulation, or both, using safe and well-established techniques of middle ear surgery...
  37. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    RYAN PATRICK JACKSON; Fiscal Year: 2010
    ..This may be particularly important for post-surgical HF hearing preservation. ..
  38. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..project will concentrate on two particular descending systems, the medial olivocochlear (MOC) neurons and the middle ear muscle (MEM) motoneurons...
  39. 3-D optical imaging of the in vivo organ of Corti motion at a sub-nanometer scale
    Alfred L Nuttall; Fiscal Year: 2013
    ..develop also has other applications for human health in Otolaryngology: OCT could image the vibration of the middle ear structures as an audiometric method, measure blood flow in the human inner ear to classify which patients with ..
  40. Mechanics of Human Middle & Inner Ear: Basic Science &Clinical Application
    Hideko Heidi Nakajima; Fiscal Year: 2013
    ..The measurements of BC-evoked DP will elucidate BC mechanisms and improve applications of BC for diagnosis and treatment. ..
  41. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and ..
  42. Mechanisms of Persistence and Recovery in Otitis Media
    Stephen I Wasserman; Fiscal Year: 2013
    ..Aim 3 will elucidate the mechanisms by which recovery from inflammation is regulated in the middle ear (ME), and determine whether pro-recovery factors can ameliorate acute and persistent ME disease...
  43. Proteomic networks of MUC5B infectious/inflammatory induction in Otitis Media
    Diego Preciado; Fiscal Year: 2013
    ..It is a disease of the middle ear space characterized by acute infectious injury and inflammation, acute OM (AOM), progressing to chronic ..
  44. Metabolic regulation in otitis media
    DAYLE ANITA DAINES; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: antibiotic treatment failure in children that results in recurrent middle ear infections (otitis media). These episodes can lead to deafness as well as language development delays...
  45. Phenotypic and Genomic Characterization of Microtia in the Andean Population
    Daniela Varela Luquetti; Fiscal Year: 2013
    ..the severity of outer ear malformation as well as the presence and pattern of hearing impairment and inner and middle ear anomalies...
  46. Phenotypic and Genomic Characterization of Microtia in the Andean Population
    Daniela Varela Luquetti; Fiscal Year: 2012
    ..the severity of outer ear malformation as well as the presence and pattern of hearing impairment and inner and middle ear anomalies...
  47. Middle Ear Response in Otitis Media
    Allen F Ryan; Fiscal Year: 2013
    ..Upon resolution of otitis media the hyperplastic middle ear mucosa can recover to a condition at or close to its original structure, although permanent changes including ..
  48. Structure and Function Relations in Middle Ears
    John J Rosowski; Fiscal Year: 2012
    ..We focus now on four new clinically-relevant structure- function issues: (1) We quantify the contribution of the middle ear to the shape of the auditory threshold curve by (a) comparing middle-ear inputs and outputs to quantify the ..
  49. Investigations of Human Auditory Mechanics
    Hideko Heidi Nakajima; Fiscal Year: 2012
    ..semicircular canal dehiscence;2. discontinuity of the ossicular chain;3. non-aerated middle ear;and 4. stapes fixation (as in Aim 1)...
  50. Dx Ear: An automated tool for diagnosis of otitis media
    JELENA KOVACEVIC; Fiscal Year: 2010
    ..AOM represents a bacterial super infection of the middle ear fluid and OME a sterile effusion that tends to subside spontaneously...
  51. Computer-based holography and middle-ear function
    John J Rosowski; Fiscal Year: 2013
    ..theory that delays associated with wave-travel on the TM contribute to delays in sound-conduction through the middle ear. Additional TM surface and ossicular motion measurements made with modified and artificial ear canals test a ..
  52. Genetic regulation of Inner and Middle Ear Development
    Andrew K Groves; Fiscal Year: 2013
    ..Moreover, the mesenchyme of the first and second branchial arches that generate the middle ear ossicles and the pinna begins to form in Foxi3 mutants, but rapidly succumbs to massive cell death...
  53. INNER EAR FLUID INTERACTIONS
    Alec N Salt; Fiscal Year: 2013
    ..This includes study of the rate of drug elimination from the middle ear and how the applied volume affects perilymph concentration...
  54. Backward and Forward Driven Eardrum Motions
    Jeffrey Tao Cheng; Fiscal Year: 2013
    ..3) Quantify the relationship between (a) TM surface motions and sound energy transmission through the middle ear to the cochlear excitations and (b) Ossicular motion and the sound transformation by the TM in reverse ..
  55. CFM: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK)
    MATTHEW LOUIS SPELTZ; Fiscal Year: 2013
    ..This condition is frequently associated with malformations of the outer, inner and middle ear, mandible, soft tissue, and facial nerve, resulting in varying degrees of facial asymmetry...
  56. Development of Stop Consonants in Children with Repaired Cleft Palate
    David J Zajac; Fiscal Year: 2013
    ..The specific aims of the proposed project are to determine 1) the time course and factors - middle ear status, symbolic language, cleft type, and sex - that account for the emergence of stop consonants in children ..
  57. Middle Ear Pressure Regulation in Health and Disease
    William J Doyle; Fiscal Year: 2013
    ..past 6 years, we have established a unique, NIH funded, Clinical Research Center focused on the physiology of middle ear (ME) pressure (MEP) regulation...
  58. Dynamic Composite Multi-Gradient Systems for Advanced MRI
    Dennis L Parker; Fiscal Year: 2013
    ..This project will use a novel composite gradient system to test that images of the fine structure of inner and middle ear anatomy obtained with magnetic resonance imaging (MRI) and, ultimately, the diagnosis of inner and middle ear ..
  59. Innovative therapy for diseases of the middle ear
    Allen F Ryan; Fiscal Year: 2013
    ..To enhance medical treatment of middle ear disorders, we used sequential selection of phage-display peptide libraries to identify rare, novel peptides that ..
  60. Observing auditory mechanics with pressure and motion measurements
    Elizabeth S Olson; Fiscal Year: 2013
    ..The projects of the first four aims continue and extend our previous work on inner and middle ear mechanics. The final aim develops and evaluates a new method for deep cochlear implant insertion...
  61. Neural Plasticity in the Adult Gustatory System
    David L Hill; Fiscal Year: 2013
    ..Results will also enable a clearer understanding of the neurobiological sequelae of human taste nerve damage sustained pathologically, or during middle ear or oral surgery.
  62. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
    ..range from the simple (myringotomy and tympanostomy tube insertion) to the complex (total reconstruction of the middle ear after mastoidectomy)...
  63. Bacterial biofilms in otitis media
    WILLIAM E SWORDS; Fiscal Year: 2013
    ..The completion of the proposed work will enhance our understanding of the role of biofilms within the clinical context of otitis media. ..
  64. DEVELOPMENT OF A FIMBRIN VACCINE AGAINST OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 1999
    Otitis media, or middle ear infection, is the second most prevalent childhood disease with hearing loss its most common complication...
  65. Coupling Strategies for Middle Ear Protheses
    ANN GRONDA; Fiscal Year: 2003
    ..Based on these measures, biocompatible adhesives whose physical properties match those of middle ear structures will be selected and characterized in bench and temporal bone studies...
  66. Central auditory pathway of the middle ear reflex
    Daniel Lee; Fiscal Year: 2007
    The goal of this project is to understand the anatomic and physiologic features of interneurons of the mammalian middle ear muscle (MEM) reflex pathway...
  67. AMPLIFICATION, MIDDLE EAR PATHOLOGY AND ACADEMIC SUCCESS
    NICKOLA NELSON; Fiscal Year: 1993
    ..concept comprehension, and teacher ratings of educational risk among first grade children with and without middle ear pathology (measured by repeated tympanometric and pure-tone screening procedures using ASHA, 1990, guidelines)...
  68. CYLD as a negative regulator for MUC5AC in NTHi-induced otitis media
    Erika Szymanski; Fiscal Year: 2007
    ..infection directly provokes pain and conductive hearing loss by stimulating mucus overproduction in the middle ear. Mucus is largely the product of mucin glycoproteins including MUC5AC, which is strongly upregulated by ..