- Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear
Center for Microbial Pathogenesis, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, College of Medicine and Public Health, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
Infect Immun 73:3210-8. 2005
..NTHI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation in vivo might play an important role in the pathogenesis and chronicity of OM...
- Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
W Edward Swords
Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Infect Immun 72:106-13. 2004
..N-acetyl-neuraminic) acid promotes biofilm formation by NTHi in vitro and bacterial persistence within the middle ear or lung in vivo...
- Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice
Jae Hyang Lim
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 2:e1032. 2007
..Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice...
- Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate
J H Ryu
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 166 Kumi Ro, Bundang gu, Seongnam si, Kyonggi do 463 707, Republic of Korea
Br J Anaesth 103:490-5. 2009
This prospective, randomized study was designed to compare remifentanil and magnesium sulphate during middle ear surgery in terms of postoperative pain and other complications.
- Otoendoscopy in cholesteatoma surgery of the middle ear: what benefits can be expected?
ORPAC ENT Department Face and Neck Surgery Clinique du Palais, Grasse, France www orpac grasse com
Otol Neurotol 29:1085-90. 2008
This study was conducted with the aim of determining the contribution of otoendoscopy in the surgical management of cholesteatoma of the middle ear.
- Middle ear pressure regulation--complementary active actions of the mastoid and the Eustachian tube
Department of Otolaryngology Head and Neck Surgery, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
Otol Neurotol 31:603-11. 2010
b>Middle ear pressure (MEP) is actively regulated by both the Eustachian tube and the mastoid air cell system.
- Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
J Clin Microbiol 46:3808-10. 2008
Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains...
- Evidence of local antibody response against Alloiococcus otitidis in the middle ear cavity of children with otitis media
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
FEMS Immunol Med Microbiol 49:41-5. 2007
..otitidis has a pathogenic role and induces local immune response in the middle ear as a true pathogen. Whole bacterial sonicate of A...
- Characterization of a temperature-sensitive mouse middle ear epithelial cell line
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
Acta Otolaryngol 125:823-9. 2005
Temperature-sensitive mouse middle ear epithelial cells have been successfully established and characterized.
- Induction of mucous cell metaplasia in the middle ear of rats using a three-step method: an improved model for otitis media with mucoid effusion
Department of Otolaryngology, University of Minnesota Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, USA
Acta Otolaryngol 122:153-60. 2002
Otitis media with mucoid effusion, characterized by mucous cell metaplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a common otological disease that frequently affects young children...
- Evolutionary development of the middle ear in Mesozoic therian mammals
Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China
Science 326:278-81. 2009
The definitive mammalian middle ear (DMME) is defined by the loss of embryonic Meckel's cartilage and disconnection of the middle ear from the mandible in adults...
- High frequency of Alloiococcus otitidis in the nasopharynx and in the middle ear cavity of otitis-prone children
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
Int J Pediatr Otorhinolaryngol 70:1009-14. 2006
Colonization of middle ear pathogens is facilitated in the nasopharynx of otitis-prone children, and is associated with the development of otitis media...
- Tetrapod-like middle ear architecture in a Devonian fish
Martin D Brazeau
Subdepartment of Evolutionary Organismal Biology, Department of Physiology and Developmental Biology, Evolutionary Biology Centre, Uppsala University, Norbyv 18A, SE 752 36 Uppsala, Sweden
Nature 439:318-21. 2006
..in the remodelling of the spiracular tract and suspensorium (jaw suspension) of osteolepiform fishes into the middle ear of tetrapods have remained elusive...
- Demonstration of nasopharyngeal and middle ear mucosal biofilms in an animal model of acute otitis media
Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
Ann Otol Rhinol Laryngol 118:292-8. 2009
We performed this study to determine the role of nasopharyngeal and middle ear (ME) biofilms in acute otitis media (AOM).
- Randomized, double-blind, placebo-controlled, dosed-finding study of the antiemetic effects and tolerability of ramosetron in adults undergoing middle ear surgery
Department of Anesthesiology, Toride Kyodo General Hospital, Toride, Japan
Clin Ther 25:3100-8. 2003
..another SSRA, in preventing emetic symptoms in adults in the first 48 hours after the start of anesthesia for middle ear surgery...
- Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
Haa Yung Lee
The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
BMC Infect Dis 8:87. 2008
..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear.
- Hag directly mediates the adherence of Moraxella catarrhalis to human middle ear cells
Department of Medical Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave, Health Education Bldg, Rm 267, Toledo, OH 43614, USA
Infect Immun 73:5127-36. 2005
..with a spectinomycin resistance cassette, and the binding of isogenic mutants to primary cultures of human middle ear epithelial cells (HMEE), as well as A549 pneumocytes, was measured...
- Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media
Department of Surgery, UCSD School of Medicine, Fir Bldg, Rm 106, 9500 Gilman Dr 0666, La Jolla, CA 92037, USA
Infect Immun 75:2562-71. 2007
..the participation of signaling via the Jun N-terminal protein kinase (JNK) mitogen-activated protein kinase in middle ear mucosal hyperplasia in animal models of bacterial otitis media...
- Prophylactic antiemetic effect of midazolam after middle ear surgery
Jae Sik Jung
Department of Anesthesiology, Kyungpook National University Hospital, Jung Gu, Daegu, Republic of Korea
Otolaryngol Head Neck Surg 137:753-6. 2007
To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
- Middle ear and cochlear disorders result in different DPOAE growth behaviour: implications for the differentiation of sound conductive and cochlear hearing loss
Daniel D Gehr
ENT Department, Technische Universitat Munchen, Clinic rechts der Isar, Ismaninger Strasse 22, D 81675 Munich, Germany
Hear Res 193:9-19. 2004
..With an inner ear dysfunction a steeper I/O-function is observed. Due to the linear sound processing of the middle ear, one can assume that the DPOAE growth behaviour remains unaltered with a sound conduction dysfunction...
- Clinically applicable multiplex PCR for four middle ear pathogens
P H Hendolin
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
J Clin Microbiol 38:125-32. 2000
..H. Hendolin, A. Markkanen, J. Ylikoski, and J. J. Wahlfors, J. Clin. Microbiol. 35:2854-2858, 1997) in middle ear effusions (MEEs) was modified to be better suited for clinical use...
- Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
Int J Pediatr Otorhinolaryngol 73:677-80. 2009
..In the middle ear, proinflammatory cytokines and chemokines are released in association with infection by pathogens, and these ..
- Modeling of the human middle ear using the finite-element method
Department of Mechanical Engineering, Tohoku University, Sendai, Japan
J Acoust Soc Am 111:1306-17. 2002
In this study, a three-dimensional finite-element model (FEM) of the human middle ear was established, including features of the middle ear which were not considered in the previous model, i.e...
- Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution
Abigail S Tucker
Department of Craniofacial Development and Orthodontics, Kings College London, Floor 28, Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Development 131:1235-45. 2004
The middle ear apparatus is composed of three endochondrial ossicles (the stapes, incus and malleus) and two membranous bones, the tympanic ring and the gonium, which act as structural components to anchor the ossicles to the skull...
- TORP-vibroplasty: a new alternative for the chronically disabled middle ear
Karl Bernd Huttenbrink
Department of Otorhinolaryngology Head and Neck Surgery, University Clinic, Cologne, Germany
Otol Neurotol 29:965-71. 2008
Surgery can often eradicate chronic middle ear disease in patients with recurrent cholesteatoma, tubal dysfunction, and others; however, in many cases, social hearing cannot be restored even after multiple revision tympanoplasties...
- Congenital malformations of the external and middle ear
Department of Diagnostic Radiology, University of Halle, Germany
Eur J Radiol 69:269-79. 2009
..fields, which are necessary to know for a profound understanding of congenital malformations of the external and middle ear. Typical and less typical combinations of malformed parts of the ear can be derived from the embryogenesis...
- High-resolution imaging of the middle ear with optical coherence tomography: a feasibility study
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 50 Vassar St, Room 36-345, Cambridge, MA 02139, USA
Arch Otolaryngol Head Neck Surg 127:637-42. 2001
..OBJECTIVE: To demonstrate the feasibility of using OCT for ultra-high-resolution imaging of the middle ear via ex vivo imaging studies of human tissue...
- Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001
Anders Rørbaek Madsen
Odense University Hospital, Sdr Boulevard 29, Odense, Denmark
Head Neck 30:1332-8. 2008
..In the context of the Danish Head and Neck Cancer Group, nationwide material from 1992-2001 was analyzed to study the extent and nature of the disease, evaluate treatment, compare staging systems, and examine prognosis and survival...
- Evaluation of middle ear function in young children: clinical guidelines for the use of 226- and 1,000-Hz tympanometry
ExpORL, Department Neurosciences, K U Leuven, Leuven, Belgium
Otol Neurotol 28:727-32. 2007
..The aims of the study were to evaluate tympanometry with regard to age and classification system using two probe-tone frequencies and to provide clinical guidelines...
- Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media
Sean D Palacios
Department of Surgery Otolaryngology, University of California San Diego, La Jolla, 92037, USA
Infect Immun 72:4662-7. 2004
Hyperplasia of the middle ear mucosa contributes to the sequelae of acute otitis media...
- IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion
Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
Acta Otolaryngol 123:383-7. 2003
The purpose of this study was to evaluate eosinophil infiltration as well as IL-5 and eotaxin levels in middle ear effusion (MEE) and blood from otitis media with effusion (OME) patients with asthma and to compare the findings with those ..
- Evaluation of implantable actuators by means of a middle ear simulation model
Department of Medicine, Technische Universitat Dresden, Germany
Hear Res 263:145-51. 2010
..now a great variety of devices available with different actuator concepts and different attachment points to the middle ear or inner ear fluid...
- A comparison of total intravenous with balanced anaesthesia for middle ear surgery: effects on postoperative nausea and vomiting, pain, and conditions of surgery
Medway Maritime Hospital, Gillingham, UK
Anaesthesia 58:176-80. 2003
We compared postoperative nausea and vomiting (PONV), pain and conditions for surgery in patients scheduled for middle ear surgery...
- Remifentanil induces consistent and sustained controlled hypotension in children during middle ear surgery
Christian S Degoute
Department of Anesthesiology, Centre Hospitalo Universitaire Lyon Sud, France
Can J Anaesth 50:270-6. 2003
To determine in children whether remifentanil combined with sevoflurane, could induce controlled hypotension, reduce middle ear blood flow (MEBF) measured by laser-Doppler, and provide a satisfactory operative field.
- Interleukin-1beta upregulates Na+-K+-2Cl- cotransporter in human middle ear epithelia
Su Jin Kim
The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Korea
J Cell Biochem 101:576-86. 2007
..suggested that the altered functions of ion channels and transporters are involved in the fluid collection of middle ear cavity of OME patients...
- Aggressiveness and quantification of epithelial proliferation of middle ear cholesteatoma by MIB1
Departments of Otorhinolaryngology, centre hospitalier universitaire Lille, Lille, France
Laryngoscope 113:328-31. 2003
..To assess an easy method that predicts cholesteatoma aggressiveness...
- Taste function after section of chorda tympani nerve in middle ear surgery
Department of Otolaryngology, Hyogo College of Medicine, Mukogawa, Nishinomiya City, Hyogo 663 8501, Japan
Auris Nasus Larynx 33:13-7. 2006
To investigate prospectively the clinical manifestations and the functional recovery of taste after section of chorda tympani nerve (CTN) during middle ear surgery, the subjective and objective study on the patients was performed.
- Interleukin-1beta suppresses epithelial sodium channel beta-subunit expression and ENaC-dependent fluid absorption in human middle ear epithelial cells
Jae Young Choi
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
Eur J Pharmacol 567:19-25. 2007
..In this study, we investigated the role of epithelial sodium channel (ENaC) in fluid absorption in normal human middle ear epithelial (NHMEE) cells, as well as the effects of Interleukin (IL)-1beta on ENaC expression and fluid ..
- Neuro-endocrine adenoma of the middle ear: a case study
Department of ENT, Head and Neck Surgery, CHRU Bretonneau, 2 boulevard Tonnelle, 37044, Tours, France
Eur Arch Otorhinolaryngol 264:1525-8. 2007
Neuroendocrine adenomas are rare tumors, which can appear in the middle ear. Approximately a hundred cases have been reported in the literature...
- Middle ear adenoma
Orlando Regional Healthcare System Department of Pathology M D Anderson Cancer Center, Orlando, Florida 32806, USA
Arch Pathol Lab Med 130:1067-9. 2006
b>Middle ear adenoma is a benign tumor of the middle ear that can have exocrine (mucinous) and/or neuroendocrine differentiation...
- The effect of dexmedetomidine on middle ear pressure
Department of Otorhinolaryngology, Inonu University, Malatya, Turkey
Otolaryngol Head Neck Surg 137:218-23. 2007
..The aim of this study was to evaluate the influence of this novel agent on middle ear pressure.
- Developmental changes in word recognition threshold from two to five years of age in children with different middle ear status
Amanda J Hall
Centre for Hearing and Balance Studies, University of Bristol, UK
Int J Audiol 46:355-61. 2007
..However by 61 months, previous OME status was not significant. To our knowledge, this is the largest longitudinal study reporting WRT in preschool children with different middle ear status.
- Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
Sung Kyun Moon
Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
Biochim Biophys Acta 1590:41-51. 2002
..the presence of molecules of innate immunity such as lysozyme and lactoferrin has been demonstrated in the middle ear, to date there have been no reports on the expression of beta-defensin 2...
- In vivo demonstration of the absorptive function of the middle ear epithelium
Ji ping Li
Otolaryngology Head Neck Surgery Department, Ren Ji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Hear Res 210:1-8. 2005
The present study investigated in vivo fluid and ion transport across the middle ear epithelium. The tympanic membrane of rats was punctured under general anesthesia...
- Growth factors influence growth and differentiation of the middle ear mucosa
S D Palacios
Department of Head and Neck Surgery, University of California-San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Laryngoscope 111:874-80. 2001
..of this study to determine which growth factors might be responsible for the growth and differentiation of the middle ear epithelium during otitis media...
- Activation of epithelial sodium channel in human middle ear epithelial cells by dexamethasone
Eun Jin Son
Department of Otorhinolaryngology, National Medical Center, Seoul, South Korea
Eur J Pharmacol 602:383-7. 2009
The middle ear epithelium functions to maintain a fluid-free middle ear cavity...
- Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium
Department of Developmental Biology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
Development 127:4127-36. 2000
..Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes...
- Environmental tobacco smoke and middle ear disease in preschool-age children
C E Adair-Bischoff
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Alberta
Arch Pediatr Adolesc Med 152:127-33. 1998
To determine the association between environmental tobacco smoke and middle ear disease in pre-school age children.
- [The relevance of Choukroun's Platelet-Rich Fibrin (PRF) during middle ear surgery: preliminary results]
Institut Azuréen d ORL et de Chirurgie de la Face, 25 Avenue Jean Médecin, F 06000 Nice, France
Rev Laryngol Otol Rhinol (Bord) 130:175-80. 2009
..To evaluate the relevance of Leucocyte- and Platelet-Rich Fibrin (L-PRF, Choukroun's technique) Concentrates during tympanoplasty...
- Analysis of chick (Gallus gallus) middle ear columella formation
Jamie L Wood
Clemson University, Biological Sciences, Long Hall, Clemson, SC 29634, USA
BMC Dev Biol 10:16. 2010
The chick middle ear bone, the columella, provides an accessible model in which to study the tissue and molecular interactions necessary for induction and patterning of the columella, as well as associated multiple aspects of endochondral ..
- Histologic analysis of the effects of three different support materials within rat middle ear
Department of Otolaryngology, Haydarpasa Training Hospital, Istanbul, Turkey
Otolaryngol Head Neck Surg 140:177-82. 2009
To investigate histologic changes in the mucosa of rat middle ear after implantation of three different support materials.
- Middle ear cancer: a population-based study
Richard K Gurgel
Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
Laryngoscope 119:1913-7. 2009
Primary carcinoma of the middle ear is a rare clinical entity, best suited for evaluation using a population-based database...
- Steroid control of acute middle ear inflammation in a mouse model
Carol J Macarthur
Department of Otolaryngology Head and Neck Surgery and Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
Arch Otolaryngol Head Neck Surg 135:453-7. 2009
..Glucocorticoids and mineralocorticoids have differential effects on inflammation and fluid absorption, but little is known of their control of middle and inner ear manifestations of acute otitis media...
- Defects in middle ear cavitation cause conductive hearing loss in the Tcof1 mutant mouse
Carol A Richter
Department of Craniofacial Development, Dental Institute, King s College London, London SE1 9RT, UK
Hum Mol Genet 19:1551-60. 2010
..of the mechanisms underlying CHL remains, particularly with respect to the molecular mechanisms underlying middle ear development and disease...
- Adenoma in the middle ear: a report of two cases
S E Jones
Department of ENT Surgery, Ipswich Hospital, Ipswich, UK
J Laryngol Otol 115:216-9. 2001
..We discuss the pathology of middle-ear adenoma, its diagnosis and treatment, and suggest ways of improving its management...
- Otologics Middle Ear Transducer Ossicular Stimulator: performance results with varying degrees of sensorineural hearing loss
Herman A Jenkins
University of Colorado Health Sciences Center, Denver, CO 80202, USA
Acta Otolaryngol 124:391-4. 2004
This study was conducted to demonstrate the safety and efficacy of the Otologics Middle Ear Transducer (MET) Ossicular Stimulator and, in particular, to compare the audiologic benefits of this novel form of electromechanical stimulation ..
- Mucin gene 19 (MUC19) expression and response to inflammatory cytokines in middle ear epithelium
Joseph E Kerschner
Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI, 53226, USA
Glycoconj J 26:1275-84. 2009
Mucin gene 19 (MUC19) has been identified as a major gel-forming mucin in the human middle ear (ME)...
- Surgical anatomy of the rat middle ear
R F Judkins
Department of Otolaryngology Head and Neck Surgery, Medical College of Ohio, Toledo 43699 0008, USA
Otolaryngol Head Neck Surg 117:438-47. 1997
This study was designed to aid experimental otologic studies of the rat middle ear. The topographic anatomy of the albino rat middle ear is described...
- Totally implantable active middle ear implants: ten years' experience at the University of Tübingen
H P Zenner
Department of Otolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
Adv Otorhinolaryngol 69:72-84. 2010
Active middle ear implants do not produce acoustic sounds but, rather, micromechanical vibrations...
- Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants
H H Tong
Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
Infect Immun 69:3678-84. 2001
..compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cell cytokine and chemokine gene expression and production in vitro...
- MUC5AC expression in human middle ear epithelium of patients with otitis media
Joseph E Kerschner
Division of Pediatric Otolaryngology, Children s Hospital of Wisconsin, 9000 W Wisconsin Ave, Milwaukee, WI 53226, USA
Arch Otolaryngol Head Neck Surg 136:819-24. 2010
To compare levels of middle ear (ME) MUC5AC expression in patients with otitis media (OM) with patients without OM...
- Ventral approach to the rat middle ear for otologic research
Department of Otorhinolaryngology, Clinica Puerta de Hierro, Universidad Autonoma, Madrid, Spain
Otolaryngol Head Neck Surg 124:515-7. 2001
To describe a simple approach to the rat middle ear because there are few clear descriptions of this technique with minimal morbidity and mortality.
- Active middle ear implant application in case of stapes fixation: a temporal bone study
Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, Colorado 80045, U S A
Otol Neurotol 31:1027-34. 2010
Driving the oval window directly with an active middle ear implant (AMEI) can produce high levels of input to the inner ear.
- Prevention of PONV by acustimulation with capsicum plaster is comparable to ondansetron after middle ear surgery
Mahender Nath Misra
Department of Anesthesiology, MLN Medical College and Associated Hospitals, Allahabad, India
Can J Anaesth 52:485-9. 2005
..To compare the efficacy of stimulation of P6 acupoint with capsicum plaster in comparison with iv ondansetron for the prevention of postoperative nausea and vomiting (PONV)...
- Cochlear effects of mesna application into the middle ear
E N T Clinic, University of Parma, Italy
Ann N Y Acad Sci 884:425-32. 1999
..The aim of this study was to evaluate the toxicity of mesna application into the middle ear on the cochlear anatomy and physiology. Three groups of guinea pigs were used as subjects...
- Mucin gene expression and mouse middle ear epithelium
Joseph E Kerschner
Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, United States
Int J Pediatr Otorhinolaryngol 74:864-8. 2010
To investigate the expression of recently identified human mucin genes in an in vitro model of cultured mouse middle ear epithelial cells (MMEEC).
- MRI and CT of adenomatous tumours of the middle ear
Department of Diagnostic Radiology, University of Cologne Medical School, Germany
Neuroradiology 43:58-61. 2001
..All showed contrast enhancement and similar signal intensity as brain tissue on T1- and T2-weighted images. The biological nature of the tumours was not reflected by the imaging or operative findings...
- Comparison of in-situ calibration methods for quantifying input to the middle ear
James D Lewis
Boys Town National Research Hospital, 555 North 30th Street, Omaha, Nebraska 68131, USA
J Acoust Soc Am 126:3114-24. 2009
..FPL and IPL were both investigated as measures of sound-level entering the middle ear. FPL may be a better measure of middle-ear input because IPL is more dependent on middle-ear reflectance and ear-..
- Magnetic resonance imaging of the mastoid cavity and middle ear: prevalence and clinical significance of incidental abnormal findings in a nonotolaryngologic adult and pediatric population
Dong Hee Lee
Department of Otolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
J Otolaryngol 35:13-8. 2006
The purposes of this study were to determine the prevalence of abnormalities in the mastoid cavity and middle ear in a nonotolaryngologic population and to correlate the results with clinical data.
- Middle ear and mastoid glomus tumors (glomus tympanicum): an algorithm for the surgical management
Gruppo Otologico, Piacenza Rome, Italy
Auris Nasus Larynx 37:661-8. 2010
Glomus tumors are slow-growing benign lesions and represent the most common primary neoplasms of the middle ear. The objective of the present study is to report our surgical strategy in the management of glomus tympanicum tumors.
- Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear
Ming Yang Lee
Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center, Tainan, Taiwan
J Craniofac Surg 17:797-800. 2006
..GCT of the right petrous temporal bone extending into the contiguous middle cranial fossa, infratemporal space, middle ear and external ear canal...
- Changes of oral trigeminal sensitivity in patients after middle ear surgery
Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, Germany
Laryngoscope 117:1636-40. 2007
..The specific aim of this study was to re-investigate the effect of chorda tympani damage on both trigeminal sensitivity and taste ability...
- Facial canal anatomy in patients with mandibulofacial dysostosis: comparison with respect to the severities of microtia and middle ear deformity
Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Otol Neurotol 26:803-8. 2005
To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with mandibulofacial dysostosis using high-resolution computed tomography.
- Antiemetic efficacy of dexamethasone combined with midazolam after middle ear surgery
Department of Anesthesiology, Kyungpook National University Hospital, Daegue, Republic of Korea
Otolaryngol Head Neck Surg 141:684-8. 2009
To evaluate the antiemetic efficacy of dexamethasone combined with midazolam after middle ear surgery.
- Multiple osteomas in the middle ear
Chang Woo Kim
Department of Otorhinolaryngology Head and Neck Surgery, Hallym University College of Medicine, 445 Gil Dong, Gangdong gu, Seoul 134 701, Korea
Eur Arch Otorhinolaryngol 263:1151-4. 2006
Osteomas in the middle ear are extremely rare and are generally solitary and small...
- On the physics of the infant feeding bottle and middle ear sequela: ear disease in infants can be associated with bottle feeding
C E Brown
Mt Zion Family Care Center, Southern Illinois University School of Medicine, 1200 North State Highway 121, Mt Zion, IL 62549 USA
Int J Pediatr Otorhinolaryngol 54:13-20. 2000
..The negative pressure inside the bottle causes the infant to suck excessively and the intraoral negative pressure may subsequently be transmitted to the middle ear via the eustachian tube.
- Partial characterization of normal and Haemophilus influenzae-infected mucosal complementary DNA libraries in chinchilla middle ear mucosa
Joseph E Kerschner
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee 53226, USA
Ann Otol Rhinol Laryngol 119:270-8. 2010
We sought to construct and partially characterize complementary DNA (cDNA) libraries prepared from the middle ear mucosa (MEM) of chinchillas to better understand pathogenic aspects of infection and inflammation, particularly with respect ..
- Detection of mucin gene expression in normal rat middle ear mucosa by reverse transcriptase-polymerase chain reaction
Y P Chen
Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210-1282, USA
Acta Otolaryngol 121:45-51. 2001
..The mechanisms controlling mucin secretion in the middle ear are not completely understood...
- Computer-integrated finite element modeling of human middle ear
School of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK 73019, USA
Biomech Model Mechanobiol 1:109-22. 2002
The objective of this study was to produce an improved finite element (FE) model of the human middle ear and to compare the model with human data...
- Role of transtympanic endoscopy of the middle ear in the diagnosis of perilymphatic fistula in patients with sensorineural hearing loss or vertigo
Department of Otolaryngology, Helsinki University Central Hospital, Helsinki, Finland
ORL J Otorhinolaryngol Relat Spec 64:301-6. 2002
The diagnosis of perilymphatic fistula (PLF) is often difficult, and therefore the condition can be overlooked. Tympanoscopy presents an alternative procedure for visualising the middle ear anatomy, and it may help to diagnose PLF.
- Virtual CT otoscopy of the middle ear and ossicles in dogs
College of Veterinary Medicine, Konkuk University, Veterinary Diagnostic Imaging
Vet Radiol Ultrasound 49:545-50. 2008
Virtual otoscopy enables noninvasive 3D endoluminal imaging of the middle ear through postprocessing of computed tompgraphy (CT) data...
- Minimally invasive, image-guided, facial-recess approach to the middle ear: demonstration of the concept of percutaneous cochlear access in vitro
Robert F Labadie
Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8605, USA
Otol Neurotol 26:557-62. 2005
Image-guided surgery will permit accurate access to the middle ear via the facial recess using a single drill hole from the lateral aspect of the mastoid cortex.
- Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis
Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wakayama, Japan
ORL J Otorhinolaryngol Relat Spec 66:233-40. 2004
..isolates of Streptococcus pneumoniae and 30 isolates of Haemophilus influenzae from paired nasopharynx and middle ear fluids of 21 children with acute otitis media (AOM) were evaluated to determine genotypes by polymerase chain ..
- Retinoic acid disturbs mouse middle ear development in a stage-dependent fashion
Max Planck Institute of Immunobiology, Freiburg, Germany
Dev Biol 184:175-86. 1997
The mammalian middle ear contains a chain of three ossicles, the malleus, incus, and stapes, that transmit into the inner ear the vibrations produced in the tympanic membrane by aerial sound...
- Middle ear structure and bone conduction in Spalax, Eospalax, and Tachyoryctes mole-rats (Rodentia: Spalacidae)
Matthew J Mason
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Morphol 271:462-72. 2010
- Virtual endoscopy of the middle ear: experimental and clinical results of a standardised approach using multi-slice helical computed tomography
Department of Neuroradiology, Medical School Hannover, Carl Neuberg Strasse 1, Germany
Eur Radiol 12:1684-92. 2002
Virtual endoscopy (VE) enables non-invasive 3D endoluminal imaging of the middle ear by post-processing of CT data. To optimise the clinical application a standardised approach was evaluated in normal and pathologic cases...
- The human anterior tympanic artery. A nutrient artery of the middle ear with highly variable origin
Department 2, Institute of Anatomy, University of Vienna, Austria
Cells Tissues Organs 166:388-94. 2000
..the deep auricular, middle, and accessory meningeal, as well as the posterior deep temporal, inferior alveolar and masseteric arteries were found to form common trunks with the anterior tympanic artery...
- ENaC- and CFTR-dependent ion and fluid transport in human middle ear epithelial cells
Jae Young Choi
Department of Otorhinolaryngology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu Seoul, 120 752, Republic of Korea
Hear Res 211:26-32. 2006
Ion channels, such as the epithelial sodium channel (ENaC), are essential for maintaining a fluid-free middle ear cavity by controlling periciliary fluid...
- Selective expression of aquaporin 1, 4 and 5 in the rat middle ear
Department of Pharmacology, Miyazaki Medical College, Kiyotake, Japan
Hear Res 158:51-6. 2001
The middle ear cavity is an air-filled space that must be maintained for effective sound transmission to the inner ear...
- Acoustic responses of the human middle ear
S E Voss
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Hear Res 150:43-69. 2000
Measurements on human cadaver ears are reported that describe sound transmission through the middle ear. Four response variables were measured with acoustic stimulation at the tympanic membrane: stapes velocity, middle-ear cavity sound ..
- In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation
Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan
Acta Otolaryngol 126:801-10. 2006
These experimental findings suggest the feasibility of artificial middle ear mucosa grafting as an effective treatment for achieving mucosal regeneration after middle ear surgery.
- Difference in facial canal anatomy in terms of severity of microtia and deformity of middle ear in patients with microtia
Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Laryngoscope 113:635-9. 2003
To study the difference in the facial canal anatomy in terms of the severity of microtia and deformity of the middle ear in patients with microtia using high-resolution computed tomography (HRCT).
- Squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Otol Neurotol 27:242-8; discussion 249. 2006
..Treatment outcomes for squamous cell carcinoma of the temporal bone were evaluated regarding stage, therapeutic strategy, and prognostic factors...
- Virtual endoscopy imaging of the middle ear cavity and ossicles
T S Karhuketo
Department of Otorhinolaryngology, Tampere University Hospital, Finland
Eur Arch Otorhinolaryngol 259:77-83. 2002
..Virtual endoscopic images were produced with separate, commercially available software, paying attention to the middle ear cavity and ossicles...
- The mastoid as a functional rate-limiter of middle ear pressure change
William J Doyle
Department of Otolaryngology, University of Pittsburgh School of Medicine, 3000 Mt Royal Blvd, Glenshaw, PA 15116, USA
Int J Pediatr Otorhinolaryngol 71:393-402. 2007
The physiological function of the mastoid air cell system (MACS) with respect to middle ear (ME) pressure-regulation remains controversial because predictive mathematical models and experimental data to formulate and test hypotheses are ..
- Measurements of human middle ear forward and reverse acoustics: implications for otoacoustic emissions
Stanford University, Mechanics and Computation Division, Palo Alto, California 94305, USA
J Acoust Soc Am 113:2773-89. 2003
..These measurements can be used to fully characterize the middle ear as a two-port system...
- Signaling pathways in interleukin-1beta-mediated middle ear mucin secretion
Joseph E Kerschner
Division of Pediatric Otolaryngology and the Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Laryngoscope 116:207-11. 2006
..protein kinase C (PKC), and nitric oxide synthase (NOS) pathways during upregulation of mucin secretion by middle ear epithelium after exposure to interleukin-1beta and to examine the ability of a specific interleukin-1 receptor ..
- Middle ear impedance measurements in large vestibular aqueduct syndrome
Ege University, Medical School, Department of Otorhinolaryngology, Izmir, Turkey
Auris Nasus Larynx 36:263-8. 2009
To assess the effect of inner ear pressure on middle ear impedance in patients with large vestibular aqueduct syndrome (LVAS).
- Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma
Department of Otolaryngology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
Clin Exp Allergy 31:1135-43. 2001
..with intractable otitis media associated with bronchial asthma have extensive accumulation of eosinophils in the middle ear mucosa and middle ear effusion, systematic histological and immunohistochemical studies have not been performed.
- The prevalence and significance of incidental middle ear and mastoid cavity abnormalities on MRI in a pediatric population
Mustafa Kemal University, Faculty of Medicine, Department of Radiology, Antakya 31100, Hatay, Turkey
Int J Pediatr Otorhinolaryngol 72:1849-54. 2008
The purposes of this study were to determine the prevalence of abnormalities in the middle ear and mastoid cavity on the magnetic resonance imaging (MRI) in children and correlate the results with clinical data, tympanometric findings and ..
- Current use of implants in middle ear surgery
R A Goldenberg
Department of Otolaryngology, Wright State University School of Medicine, Dayton, Ohio, USA
Otol Neurotol 22:145-52. 2001
..Of the 575 questionnaires mailed, 274 (47%) were returned. Only 248 of the respondents performed middle ear surgery (43%), and their responses constitute the database for this study...