Genomes and Genes
Summary: A gelatinous membrane overlying the acoustic maculae of SACCULE AND UTRICLE. It contains minute crystalline particles (otoliths) of CALCIUM CARBONATE and protein on its outer surface. In response to head movement, the otoliths shift causing distortion of the vestibular hair cells which transduce nerve signals to the BRAIN for interpretation of equilibrium.
Publications189 found, 100 shown here
- Human 3-D aVOR with and without otolith stimulationChristopher J Bockisch
Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, 8091 Zurich, Switzerland
Exp Brain Res 161:358-67. 2005..This could be because, in humans, typical yaw head movements will stimulate the otoliths to a much lesser extent then typical pitch and roll head movements...
- Detection of infrasound and linear acceleration in fishesO Sand
Department of Biology, The University of Oslo, Norway
Philos Trans R Soc Lond B Biol Sci 355:1295-8. 2000..Sensitivity to infrasound may be a widespread ability among aquatic organisms, and has also been reported in cephalopods and crustaceans...
- Elevated CO2 enhances otolith growth in young fishDavid M Checkley
Scripps Institution of Oceanography, University of California, San Diego, CA 92093, USA
Science 324:1683. 2009..We hypothesize that CO2 moves freely through the epithelium around the otoliths in young fish, accelerating otolith growth while the local pH is controlled. This is the converse of the effect commonly reported for structural biominerals...
- Natal homing in a marine fish metapopulationS R Thorrold
Department of Biological Sciences, Laboratory for Isotope and Trace Element Research, Old Dominion University, Norfolk, VA 23529, USA
Science 291:297-9. 2001..Our findings highlight the need for consideration of spatial processes in fisheries models and have implications for the design of marine reserves in coastal regions...
- Otolith and canal integration on single vestibular neurons in catsY Uchino
Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo, 160 8402, Japan
Exp Brain Res 164:271-85. 2005..Some of the convergent neurons that receive both canal and otolith input may contribute to the short-latency pathway of the vestibulocollic reflex. The functional significance of these convergences is discussed...
- Head direction cell activity in mice: robust directional signal depends on intact otolith organsRyan M Yoder
Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA
J Neurosci 29:1061-76. 2009..Furthermore, compared with rats, the HD signal in mice appears to be less reliably anchored to prominent environmental cues...
- Bone conducted vibration selectively activates irregular primary otolithic vestibular neurons in the guinea pigIan S Curthoys
Vestibular Research Laboratory, School of Psychology, University of Sydney, Sydney, NSW, Australia
Exp Brain Res 175:256-67. 2006..The BCV generates compressional and shear waves, which travel through the skull and constitute head accelerations, which are sufficient to stimulate the most sensitive otolithic receptor cells...
- Resolution of sensory ambiguities for gaze stabilization requires a second neural integratorAndrea M Green
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 23:9265-75. 2003....
- Morphological polarizations of sensory hair cells in the three otolithic organs of a teleost fish: fluorescent imaging of ciliary bundlesZ Lu
Department of Biology, University of Maryland, College Park 20742 4415, USA
Hear Res 126:47-57. 1998..Thus, the sleeper goby's ear is morphologically capable of being a three-dimensional sound detector...
- Form and function in the unique inner ear of a teleost: the silver perch (Bairdiella chrysoura)John Umar Ramcharitar
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
J Comp Neurol 475:531-9. 2004..The findings of this study support the proposal that sciaenids are excellent model species for investigating structure-function relations in the teleost auditory system...
- Ocular and perceptual responses to linear acceleration in microgravity: alterations in otolith function on the COSMOS and Neurolab flightsSteven T Moore
Mount Sinai School of Medicine, Department of Neurology, New York, NY 10029, USA
J Vestib Res 13:377-93. 2003..The findings also raise the possibility that 'artificial gravity' during the Neurolab flight counteracted adaptation of these otolith-ocular responses...
- Afferent synapses are present in utricular hair cells from otoconia-deficient miceLarry F Hoffman
Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA 90095 1624, USA
Hear Res 222:35-42. 2006..These results indicate that afferent synapses within vestibular hair cells do not critically depend upon stimulus-evoked activity...
- Otolith deprivation induces optokinetic compensationCorina E Andreescu
Department of Neuroscience, Erasmus University Medical Center Rotterdam, DR Rotterdam, The Netherlands
J Neurophysiol 94:3487-96. 2005....
- Correlated movement of hair bundles coupled to the otolithic membrane in the bullfrog sacculusC E Strimbu
University of California, Los Angeles Department of Physics and Astronomy, Los Angeles, CA 90095, USA
Hear Res 256:58-63. 2009..To maintain the natural degree of intercell coupling, the overlying otolithic membrane was left intact atop the in vitro preparation...
- Assessment of Meniere's disease from a radiological aspect - saccular otoconia as a cause of Meniere's disease?Hideo Yamane
Department of Otorhinolaryngology, Osaka City University Graduate School of Medicine, Japan
Acta Otolaryngol 132:1054-60. 2012..These structures could be involved in the pathogenesis of MD...
- Orienting otolith-ocular reflexes in the rabbit during static and dynamic tilts and off-vertical axis rotationJ Maruta
Departments of Neurology and Physiology and Biophysics, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, New York, NY 10029, USA
Vision Res 41:3255-70. 2001..Semicircular canal input broadened the band-pass of these orienting reflexes, which would make them more appropriate when compensating for head movement during active motion...
- Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculusC E Strimbu
University of California, Los Angeles Department of Physics and Astronomy and the California NanoSystems Institute, 475 Portola Plaza, Los Angeles, CA 90095, USA
Hear Res 265:38-45. 2010..under more natural loading conditions, innate oscillations are suppressed by the presence of the overlying otolithic membrane, indicating that hair bundles lie in the quiescent rather than the unstable regime...
- Resting discharge patterns of macular primary afferents in otoconia-deficient miceT A Jones
Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858 4353, USA
J Assoc Res Otolaryngol 9:490-505. 2008..The robust discharge rates are interesting in that they may reflect the presence of a functionally 'up-regulated' tonic excitatory process in the absence of natural sensory stimulation...
- Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otolithsR A Bergstrom
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Genetics 150:815-22. 1998..This approach demonstrates the utility of chromosome deletions as reagents for mapping and characterizing mutations, particularly in situations where recombinational mapping is inadequate...
- Blockage of reuniting duct in Meniere's diseaseHideo Yamane
Department of Otorhinolaryngology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
Acta Otolaryngol 130:233-9. 2010....
- Immunohistochemical localization of two otolith matrix proteins in the otolith and inner ear of the rainbow trout, Oncorhynchus mykiss: comparative aspects between the adult inner ear and embryonic otocystsEmi Murayama
Laboratory of Bioorganic Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, 113 8657 Tokyo, Japan
Histochem Cell Biol 121:155-66. 2004..These results indicate that these proteins are required as essential components for otolith formation and calcification...
- Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of CortiIsolde Thalmann
Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
Electrophoresis 27:1598-608. 2006..These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear...
- First steps of otolith formation of the zebrafish: role of glycogen?M Pisam
Departement de Biologie Joliot Curie, CEA Saclay, 91191 Gif sur Yvette Cedex, France
Cell Tissue Res 310:163-8. 2002..As a result, glycogen might play a key role in initiating the formation of otoliths and possibly that of other calcified tissues...
- Three-dimensional morphology of inner ear development in Xenopus laevisMichele Miller Bever
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Dev Dyn 227:422-30. 2003....
- Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafishJessica A Petko
Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
Dev Neurobiol 68:209-22. 2008..Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths...
- Lesions of the cerebellar nodulus and uvula in monkeys: effect on otolith-ocular reflexesMark F Walker
Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
Prog Brain Res 171:167-72. 2008....
- Osteopontin is not critical for otoconia formation or balance functionXing Zhao
Genetics Department, Boys Town National Research Hospital, Omaha, NE 68131, USA
J Assoc Res Otolaryngol 9:191-201. 2008..When compared with findings on other otoconins, the data manifest a hierarchy of importance of proteins in crystallization and indicate mechanistic similarities and differences between bone and otoconia calcification...
- Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial developmentInna Hughes
Department of Molecular Biology and Pharmacology, Rm 3902 South Building Campus Box 8103, Washington University in St Louis, School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Brain Res 1091:58-74. 2006....
- In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structureWenfu Lu
Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Hear Res 268:172-83. 2010....
- Otolith function in cerebellar ataxia due to mutations in the calcium channel gene CACNA1AG Wiest
Reed Neurological Research Center, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
Brain 124:2407-16. 2001..These findings suggest a critical role of the cerebellum in the modulation of otolith-ocular signals that is independent of motor vergence...
- Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrixXing Zhao
Genetics Department, Boys Town National Research Hospital, Omaha, NE 68131, and Center for Neuroscience, Communication Science Program, University of California at Davis 95616, USA
Dev Biol 304:508-24. 2007..Our data demonstrate the critical roles of otoconins in otoconia seeding, growth and anchoring and suggest mechanistic similarities and differences between otoconia and bone calcification...
- Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biomineralsE Verpy
Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique Unite de Recherche Associee 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 96:529-34. 1999..In addition, multiple isoforms generated by differential splicing were observed in different combinations during development. Based on the present results, we propose a model for the formation of the otoconia...
- Significance of tertiary conformation of otoconial matrix proteins - clinical implicationsRuediger Thalmann
Department of Otolaryngology Head and Neck Surgery, Washington University in St Louis, Missouri, USA
Acta Otolaryngol 131:382-90. 2011..Co-option of the enzyme secretory phospholipase A2 (sPLA2) and adoption of tertiary conformation are essential factors in the multifunctionality of otoconin 90 (OC90) and homologous modulators...
- Expression, functional, and structural analysis of proteins critical for otoconia developmentYinfang Xu
Vestibular Neurogenetics Laboratory, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
Dev Dyn 239:2659-73. 2010..Analysis and modeling of Oc90 and Sc1 protein structures show common features that may be critical requirements for the otoconial matrix backbone protein. Such information will serve as the foundation for future regenerative purposes...
- Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2Y Wang
Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 95:15345-50. 1998..The cloning of Oc90 will allow an examination of the role of this protein in otoconial biosynthesis and in diseases that affect the vestibular system...
- The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at FzS Iwasaki
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Clin Neurophysiol 120:588-93. 2009..If the n10 is due primarily to utricular activation then diseases which affect only the superior division of the vestibular nerve (SVN) should reduce or eliminate n10...
- Development and maintenance of otoconia: biochemical considerationsR Thalmann
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Ann N Y Acad Sci 942:162-78. 2001....
- A critical period of ear development controlled by distinct populations of ciliated cells in the zebrafishB B Riley
Department of Biology, Texas A and M University, College Station 77843 3258, USA
Dev Biol 191:191-201. 1997..5 to 24 h, and that interfering with the functions of tether cell kinocilia or beating cilia impairs otolith seeding and subsequent otolith morphogenesis...
- Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sicknessScott J Wood
Department of Neurotology Research, Legacy Health System, Suite 303, 1225 NE 2nd Avenue, Portland, OR 97232, USA
Neurosci Lett 323:41-4. 2002..3 Hz is the result of frequency segregation of ambiguous otolith information being inadequate to distinguish between tilt and translation...
- Effect of acute exposure to hypergravity (GX vs. GZ) on dynamic cerebral autoregulationJ M Serrador
Cerebral Blood Flow Research Lab, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
J Appl Physiol (1985) 91:1986-94. 2001..We speculate that this leftward shift may have been due to vestibular activation (especially during +GX) or potentially to an adaptation to reduced cerebral perfusion pressure during +GZ...
- Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafishBrian Blasiole
Department of Pharmacology, Penn State University College of Medicine, H078, Hershey, PA 17033, USA
Dev Biol 294:148-60. 2006..Our results highlight zebrafish gene knockdown-mRNA rescue as an approach that can be used to dissect the functional properties of zebrafish and mammalian Na,K-ATPase genes...
- Mutations affecting development of the zebrafish inner ear and lateral lineT T Whitfield
ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
Development 123:241-54. 1996..At least one mutant, dog-eared, shows defects in both the ear and another placodally derived sensory system, the lateral line, while hypersensitive mutants have additional trunk lateral line organs...
- A review of otolith pathways to brainstem and cerebellumJ A Buttner-Ennever
Institute of Anatomy, Ludwig Maximilian University of Munich, Germany
Ann N Y Acad Sci 871:51-64. 1999..The graviceptive information could be channeled by the cerebellar efferents back to the vestibular and inferior olive complex, or fed into ascending pathways that would innervate the mescencephalon, the thalamus, and cerebral cortex...
- Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafishB B Riley
Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
J Neurobiol 43:329-37. 2000..The presence of a utricular otolith in at least one inner ear is necessary and sufficient for vestibular function and survival. In contrast, saccular otoliths are dispensable for these functions...
- Semicircular canal size determines the developmental onset of angular vestibuloocular reflexes in larval XenopusFrançois M Lambert
Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, Centre National de Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris Descartes, 75270 Paris Cedex 06, France
J Neurosci 28:8086-95. 2008....
- Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculaeEmi Murayama
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, 113 8657 Tokyo, Japan
Mech Dev 122:791-803. 2005....
- Natal homing and connectivity in Atlantic bluefin tuna populationsJay R Rooker
Department of Marine Biology, Texas A and M University, 5007 Avenue U, Galveston, TX 77551, USA
Science 322:742-4. 2008..The largest (oldest) bluefin tuna collected near the northern extent of their range in North American waters were almost exclusively of western origin, indicating that this region represents critical habitat for the western population...
- The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner earJessica R Colantonio
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
Nature 457:205-9. 2009..These results demonstrate a requirement for the dynein regulatory complex in vertebrates and show that cilia-driven flow is a key epigenetic factor in controlling otolith biomineralization...
- Otoconial agenesis in tilted mutant miceD M Ornitz
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
Hear Res 122:60-70. 1998..We further demonstrate that protein expression in the macular sensory epithelium is qualitatively unaltered in tilted mutant mice...
- Gravity receptor function in mice with graded otoconial deficienciesSherri M Jones
School of Medicine, University of Missouri, Columbia, MO 65212, USA
Hear Res 191:34-40. 2004..It also shows that behavior alone may be an unreliable indicator of the extent of gravity receptor deficits...
- Asymmetric integration recorded from vestibular-only cells in response to position transientsSam Musallam
Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Neurophysiol 88:2104-13. 2002..Instead a neuron with a long membrane time constant and an excitatory postsynaptic potential duration that increases with the firing rate of the presynaptic cell can emulate the observed behavior...
- Orienting eye movements and nystagmus produced by translation while rotating (TWR)Jun Maruta
Department of Neurology and Physiology and Biophysics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
Exp Brain Res 163:273-83. 2005..We speculate that the brain may use these low amplitude rotating linear accelerations to generate eye velocities that help to orient gaze when making turns during normal locomotion...
- Horizontal vestibulo-ocular reflex dynamics in acute vestibular neuritis and viral labyrinthitis: evidence of otolith-canal interactionRaphael Maire
Clinic of Otolaryngology Head and Neck Surgery, Neurotology Unit, University Hospital Lausanne, Lausanne, Switzerland
Acta Otolaryngol 124:36-40. 2004....
- Modeling gravity-dependent plasticity of the angular vestibuloocular reflex with a physiologically based neural networkYongqing Xiang
Department of Computer and Information Science, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
J Neurophysiol 96:3349-61. 2006..The adaptation is tuned by how the weights from otolith input to the canal-otolith-convergent neurons are adapted for a given head orientation...
- Why do patients with PSP fall? Evidence for abnormal otolith responsesK Liao
Neurology Service and Daroff Dell Osso Laboratory, Veterans Affairs Medical Center and University Hospitals, Case Western Reserve University, Cleveland, OH, USA
Neurology 70:802-9. 2008..Abnormal vestibulospinal reflexes are suspected, but the angular vestibulo-ocular reflex, which is mediated by the labyrinthine semicircular canals, survives late into the course of the disease...
- Dynamic effects on the subjective visual vertical after roll rotationErika N Lorincz
Department of Neurology, University Hospital Zurich, Zurich, Switzerland
J Neurophysiol 100:657-69. 2008..This transient bias depended on both rotation and tilt direction after constant velocity rotations, but was almost abolished following constant acceleration rotations...
- Semicircular canal plugging shifts the frequency of spatial-temporal convergence (STC) in central vestibular neuronsSergei B Yakushin
Mount Sinai School of Medicine, Neurology Dept, Box 1135, 5E 98 Street, New York, NY 10029, USA
J Gravit Physiol 14:P71-2. 2007
- Dissociation between canal- and otolithfunction in cerebellar atrophySarah Marti
J Neurol 255:769-71. 2008
- Canal and otolith contributions to visual orientation constancy during sinusoidal roll rotationRonald G Kaptein
Department of Biophysics, Radboud University Nijmegen, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
J Neurophysiol 95:1936-48. 2006..Simulations showed that a linear combination of an integrated canal signal and a gravity-based signal can account for these results...
- Dizziness after canalith repositioning procedure for benign paroxysmal positional vertigoEmmanuel P Prokopakis
Auris Nasus Larynx 34:435; author reply 437. 2007
- Diagnostic and treatment strategy of lateral semicircular canal canalolithiasisG Asprella Libonati
Unit of Audiology Vestibology and Phoniatrics, Department of Otorhinolaryngology and Head Neck Surgery, Madonna delle Grazie Hospital, Matera, Italy
Acta Otorhinolaryngol Ital 25:277-83. 2005....
- Short-term efficacy of Epley's manoeuvre: a double-blind randomised trialM von Brevern
Department of Neurology, Charite, Campus Virchow Klinkum, Berlin, Germany
J Neurol Neurosurg Psychiatry 77:980-2. 2006..Thus far, the short-term efficacy of Epley's manoeuvre for treatment of PC-BPPV is unknown...
- Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translationJun Ru Tian
Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
Exp Brain Res 176:575-87. 2007..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
- 'Bow and lean test' to determine the affected ear of horizontal canal benign paroxysmal positional vertigoYun Hoon Choung
Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
Laryngoscope 116:1776-81. 2006..The purpose of this study is to develop the new "bow and lean test (BLT)" to easily determine the affected ear of HSC-BPPV and evaluate its efficiency...
- [Exploration of the otolith function]M Toupet
Centre d Explorations Fonctionnelles Oto Neurologiques, 10 rue Falguière, 75015 Paris, France
Rev Laryngol Otol Rhinol (Bord) 126:209-15. 2005..Thus a patient complaining of falling outwards is to be tested by offset rotations. A patient complaining of falling while going down in a lift is best investigated by the cortical vestibular otolith evoked potentials...
- Head-tilting stabilometry in patients with benign paroxysmal positional vertigoKenya Inukai
Department of Otolaryngology, Niigata University, Faculty of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
Auris Nasus Larynx 35:31-5. 2008..In this study, we examined changes in the parameters of stabilometry under an upright condition and head-tilt conditions in patients with BPPV...
- Vertical (Z-axis) acceleration alters the ocular response to linear acceleration in the rabbitJun Maruta
Department of Neurology, Mount Sinai School of Medicine, Box 1135, 1 Gustave L Levy Place, New York, NY 10029, USA
Exp Brain Res 185:87-99. 2008....
- Model experiments of BPPV using isolated utricle and posterior semicircular canalTaro Inagaki
Department of Otolaryngology, Tokyo Medical University, Tokyo 160 0023, Japan
Auris Nasus Larynx 33:129-34. 2006..The effect of interposed otoconia in models of canalolithiasis and cupulolithiasis were also investigated using isolated posterior semicircular canal (PSC)...
- Self-treatment for benign paroxysmal positional vertigo of the posterior semicircular canalHitosh Tanimoto
Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Neurology 65:1299-300. 2005..048). Complications occurred in 2.6% of the Epley-alone group and in 7.5% of the self-treatment group (p = 0.62)...
- Postural control in otolith disordersDietmar Basta
Department of Otolaryngology at UKB, Charite Medical School, Warener Str 7, D 12683 Berlin, Germany
Hum Mov Sci 24:268-79. 2005..In essence, otolith disorders evidently impair human postural control and have been possibly underestimated as a source of posttraumatic postural imbalance as yet...
- Otolith organ or semicircular canal stimulation induces c-fos expression in unipolar brush cells and granule cells of cat and squirrel monkeyGabriella Sekerkova
Northwestern University Institute for Neuroscience, Searle 5 474, 320 E Superior Street, Chicago, IL 60611, USA
Exp Brain Res 164:286-300. 2005....
- The high-frequency/acceleration head heave test in detecting otolith diseasesPaul Kessler
Department of Otolaryngology, University of Toronto, Toronto, Ontario, Canada
Otol Neurotol 28:896-904. 2007..To investigate whether transient, high-acceleration interaural head heaves (translational vestibulo-ocular reflex [tVOR]) could aid in the diagnosis of otolith diseases...
- Interaction between otolith organ and semicircular canal vestibulo-ocular reflexes during eccentric rotation in humansClaire C Gianna-Poulin
Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
Exp Brain Res 185:485-95. 2008..e. algebraic summation) between otolith organ and horizontal canal VORs for the generation of horizontal compensatory eye movements during head motion...
- Responses of monkey vestibular-only neurons to translation and angular rotationWu Zhou
Department of Otolaryngology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48105, USA
J Neurophysiol 96:2915-30. 2006..Significantly, recent theoretical models have predicted neurons with discharge patterns similar to those of low- and high-sensitivity neurons...
- Efficacy of the Epley maneuver for posterior canal BPPV: a long-term, controlled study of 81 patientsWietske Richard
Department of Otorhinolaryngology, Gelre Hospital, Apeldoorn, The Netherlands
Ear Nose Throat J 84:22-5. 2005..We conclude that the Epley maneuver provides effective and long-term control of symptoms in patients with BPPV...
- Vestibulo-ocular function in anxiety disordersJoseph M Furman
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Vestib Res 16:209-15. 2006..Excessive SMD and height phobia seem to have a mitigating effect on abnormal vestibular sensitivity, possibly via a down-weighting of central vestibular pathways...
- Otolith-ocular responses in patients with surgically confirmed unilateral peripheral vestibular lossJoseph M Furman
Department of Otolaryngology, University of Pittsburgh, PA, USA
J Vestib Res 13:143-51. 2003..These results have clinical implications for the management of patients with unilateral vestibular loss and provide insights into the process of vestibular compensation especially with respect to the otolith-ocular reflex...
- Canal-otolith interaction in the fastigial nucleus of the alert monkeyC Siebold
Department of Neurology, Ludwig-Maximilians University, Munich, Germany
Exp Brain Res 136:169-78. 2001..The large variety of response types allows these neurons to participate in multiple tasks of vestibulospinal movement control...
- [Diagnosis and treatment of horizontal canal benign paroxysmal positional vertigo]G Xing
Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 36:28-30. 2001..CONCLUSION: HC-BPPV is different from PC-BPPV and other vertiginous diseases in typical presentations and positional testing results. The barbecue rotation is a successful method for curing the disorder...
- A general framework for neurobiological modeling: an application to the vestibular systemChris Eliasmith
Department of Philosophy, Department of Systems Design Engineering, University of Waterloo, Waterloo, Ont, Canada
Neurocomputing 44:1071-6. 2002..The model is constructed using general principles of neurobiological simulation (J. Neurophys. 84 (2000) 2113)...
- Human vestibular memory studied via measurement of the subjective horizontal during gondola centrifugationArne Tribukait
Department of Audiology, Karolinska Hospital, S 171 76 Stockholm, Sweden
Neurobiol Learn Mem 80:1-10. 2003..Further, the SVH seems to be dependent on two different mechanisms related to semicircular canal stimulation...
- The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL/6 miceChristopher G Harrod
Northwestern University, Department of Physiology and Institute for Neuroscience, 303 East Chicago Avenue, M211, Chicago, IL 60611, USA
Brain Res 972:75-83. 2003..Because semicircular canals are normal in het mice, we conclude that central neurons of the canal VOR are dependent on otolith organ signals for normal performance...
- 3D eye movement analysis during sinusoidal off vertical axis rotation in human subjectsY Koizumi
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
Acta Otolaryngol 123:121-8. 2003..In order to investigate these characteristics, we performed a 3D analysis of eye movements induced by human sinusoidal s-OVAR, and compared the result with that of eye movements induced by constant c-OVAR...
- Response properties of Y group neurons to crossed otolith inputs in the catY S Chan
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, P R China
Neuroreport 14:729-33. 2003..The best response orientations of one-dimensional and two-dimensional neurons were found predominantly along the antero-posterior direction, thus providing a spatial framework for the otolithic reflexes...
- Effect of semicircular canal stimulation on the perception of the visual verticalMarousa Pavlou
Academic Department of Neuro Otology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London W6 8RF, United Kingdom
J Neurophysiol 90:622-30. 2003....
- Benign paroxysmal positional vertigo: some recent advancesAdolfo M Bronstein
Curr Opin Neurol 16:1-3. 2003
- Adaptive plasticity in the otolith-ocular reflexIzumi Koizuka
Department of Otolaryngology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki City, 216 8511, Kanagawa, Japan
Auris Nasus Larynx 30:S3-6. 2003..We believe that the ScOR and the OOR share common neural pathways in such a way that a change in the synaptic efficacy of one pathway is accompanied by a change in the other...
- Neural processing of gravito-inertial cues in humans. IV. Influence of visual rotational cues during roll optokinetic stimuliL H Zupan
Jenks Vestibular Physiology Laboratory, Boston 02114, USA
J Neurophysiol 89:390-400. 2003..Furthermore, as predicted, the horizontal response in the dark was larger for Tilters (n = 5) than for Non-Tilters (n = 12)...
- Eye movements during multi-axis whole-body rotationsChristopher J Bockisch
Department of Neurology, University Hospital Zurich, Switzerland
J Neurophysiol 89:355-66. 2003..Our study, supported by other experiments, also indicates that static otolith signals exhibit considerably smaller effects on eye movements in humans than in monkeys...
- Orientation of Listing's plane during static tilt in young and older human subjectsJoseph M Furman
Department of Otolaryngology, School of Medicine, University of Pittsburgh, EEI Bldg, Ste 500, Pittsburgh, PA 15213, USA
Vision Res 43:67-76. 2003..The only obvious difference between the two age groups was that the "thickness" of Listing's plane was greater in the older subjects. This suggests that aging has a small, but definite, influence on Listing's law...
- Linearity of canal-otolith interaction during eccentric rotation in humansS H Seidman
Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
Exp Brain Res 147:29-37. 2002....
- Using sensory weighting to model the influence of canal, otolith and visual cues on spatial orientation and eye movementsL H Zupan
Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston 02114, USA
Biol Cybern 86:209-30. 2002..g., centered and eccentric yaw rotation about an earth-vertical axis, yaw rotation about an earth-horizontal axis) and with visual cues (e.g., stabilized visual stimulation or optokinetic stimulation)...
- The relation of motion sickness to the spatial-temporal properties of velocity storageMingjia Dai
Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, New York, NY 10029, USA
Exp Brain Res 151:173-89. 2003....
- Model experiment of benign paroxysmal positional vertigo mechanism using the whole membranous labyrinthKoji Otsuka
Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
Acta Otolaryngol 123:515-8. 2003..A vibratory stimulus was able to detach the otoconia from the utricle, suggesting that mechanical insult could be a possible etiology of BPPV...
- Static and dynamic vestibulo-cervico-ocular responses after prolonged exposure to microgravityL N Kornilova
RF SRC Institute of Biomedical Problems, Russian Academy of Sciences, Russia
J Vestib Res 17:217-26. 2007..However, the suppressed otolith functioning in the period of readaptation to the normal gravity was, as a rule, accompanied by an exaggerated vestibular reactivity...
- Signal processing of semicircular canal and otolith signals in the vestibular nuclei during passive and active head movementsRobert A McCrea
Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
Ann N Y Acad Sci 1004:169-82. 2003..Several specific examples of how sensory information related to passive and active head movements is transformed in the vestibular nuclei are discussed...
- Nonlinear nystagmus processing causes torsional VOR nonlinearityE Schneider
Ludwig Maximilians University, Department of Neurology and Center for Sensorimotor Research, Munich, Germany
Ann N Y Acad Sci 1004:500-5. 2003..This method proved to be suitable for determining whether nonlinear processing of nystagmus frequency is responsible for the TVOR nonlinearity...
- Vestibulo-ocular physiology underlying vestibular hypofunctionMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 710 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
Phys Ther 84:373-85. 2004..The purposes of this article are to review the anatomy and physiology of the vestibular system and to describe the neurophysiological mechanisms responsible for the vestibulo-ocular abnormalities in patients with vestibular hypofunction...
- Dynamic modulation of ocular orientation during visually guided saccades and smooth-pursuit eye movementsBernhard J M Hess
Department of Neurology, Zurich University Hospital, Switzerland
Ann N Y Acad Sci 1004:132-41. 2003..It is suggested that this graviceptive control of eye orientation facilitates rapid visual spatial orientation during motion...
- Direction specific error patterns during continuous tracking of the subjective visual verticalS Keusch
Department of Neurology, University of Zurich, 8091 Zurich, Switzerland
Exp Brain Res 155:283-90. 2004..We conclude that the central processing underlying these perceptual tracking responses requires, besides the otolith input, information from the vertical semicircular canals...
- [Habituation of horizontal eye nystagmus in pigeon during alternation of central and eccentric rotations]Iu K Stolbkov
I P Pavlov Institute of Physiology, Russian Acad Sci, 199034, St Petersburg, Nab Makarova, 6, Russia
Ross Fiziol Zh Im I M Sechenova 89:738-48. 2003..These variations were not random (probability, > 95%)...
- Vestibular Hair Cell RegenerationLARRY HOFFMAN; Fiscal Year: 2007..unreadable] [unreadable]..
- VESTIBULOSYMPATHETIC REFLEXES IN HUMANSCHESTER RAY; Fiscal Year: 2005..The design of these studies will increase our understanding of how the vestibular system contributes to orthostatic blood pressure regulation in humans. ..
- VESTIBULOSYMPATHETIC REFLEXES IN HUMANSCHESTER RAY; Fiscal Year: 2001....
- Long-term Ambulatory Gait Monitor for Parkinson's DiseaseSteven Moore; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- NEURAL MECHANISMS OF SOUND LOCALIZATIONZhongmin Lu; Fiscal Year: 2007..Single-cell recording will determine if there are neurons in the medulla and/or midbrain of the goldfish that encode specific timing differences between particle motion and pressure inputs. ..
- Galvanic Effects on the Human Vestibuloocular ReflexAmerico Migliaccio; Fiscal Year: 2007..unreadable] [unreadable]..
- NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITIONNEAL BARMACK; Fiscal Year: 2005..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
- Mechanism of Opiate Induced Audiovestibular DysfunctionGail Ishiyama; Fiscal Year: 2006....
- Development of a clinical test of utricular functionClaire Gianna Poulin; Fiscal Year: 2006..Recommendations for the use of eccentric rotation as a clinical utricular test will be provided as a result of the proposed experiments. ..
- VESTIBULAR MECHANISMS IN THE DYNAMICS OF LOCOMOTIONTheodore Raphan; Fiscal Year: 2006....
- Improved Search Coil Method for Measuring Eye MovementsMark Shelhamer; Fiscal Year: 2007..abstract_text> ..
- VESTIBULAR INFLUENCES ON SPATIAL ORIENTATIONRichard Lewis; Fiscal Year: 2008..abstract_text> ..
- MULTIDIMENSIONAL DYNAMIC OF THE VESTIBULO OCULAR REFLEXTheodore Raphan; Fiscal Year: 2008..When the study is completed, we will have a quantitative model of how the vestibular system contributes to maintenance of binocular gaze stability while moving. ..
- HAIR CELL RESPONSES TO OTOTOXIC DRUGSPETER STEYGER; Fiscal Year: 2007..This may lead to new co-therapeutic treatments with aminoglycosides and (cellular) aminoglycoside-uptake inhibitors against a wider range of bacterial infections. ..
- A gene-trap screen for hearing and balanceDONNA FEKETE; Fiscal Year: 2008..Our long-term goal is to determine whether any of the newly discovered hearing-related genes in zebrafish also correspond to genes underlying congenital deafness in humans. [unreadable] [unreadable] [unreadable]..
- EFFERENT INNERVATION OF IDENTIFIED VESTIBULAR AFFERENTSAnna Lysakowski; Fiscal Year: 2008..The intent is to produce a body of morphological, neurochemical and cell biological knowledge from which physiologically and pharmacologically testable hypotheses can be derived. [unreadable] [unreadable] [unreadable]..
- Development of semicircular canal prostheses for studies of vestibular plasticityDANIEL MERFELD; Fiscal Year: 2009..abstract_text> ..
- VESTIBULO-OCULAR FUNCTION IN THE ELDERLYJoseph Furman; Fiscal Year: 2009..Taken together, these studies will provide essential information regarding the influence of aging on several specific aspects of balance and thus may have practical implications regarding the management of age-related loss of balance. ..
- SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATIONKenna D Peusner; Fiscal Year: 2010..As we learn more about the pathology induced by vestibular deafferentation at the level of vestibular nuclei neurons, effective therapies can be targeted selectively to improve the clinical management of patients with balance disorders. ..
- ENCODING OF VOCAL SIGNALS IN THE AUDITORY SYSTEMAndrew H Bass; Fiscal Year: 2011..with auditory; neuropathy/dys-synchrony.. '-.'...... ..
- Scaling in Reflexive and Volitional Eye MovementsMark Shelhamer; Fiscal Year: 2006..Since scaling changes with pathology, new means to assess vestibular or oculomotor pathology may result. ..
- RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEMNEAL BARMACK; Fiscal Year: 2003..abstract_text> ..
- FUNCTION AND PLACTICITY IN CANAL OTOLITH INTERACTIONSGARY PAIGE; Fiscal Year: 2002..Novel techniques will be explored, and specific endorgan lesions will be employed to directly assess the origin o VOR behaviors and elucidate processes that restore function. ..
- GDNF Protection in the Inner EarYehoash Raphael; Fiscal Year: 2005..The data we propose to generate will enhance our understanding of the mechanisms of action of GDNF in normal and injured inner ear epithelia, knowledge that may eventually lead to better clinical treatments ..
- Methylphenidate & gene expression in the rat brain.JOAN BAIZER; Fiscal Year: 2004..abstract_text> ..
- Pilot Studies in Adaptation in Parabolic FlightMark Shelhamer; Fiscal Year: 2004..abstract_text> ..
- Phase Transition Models of Oculomotor ControlMark Shelhamer; Fiscal Year: 2003..The work represents a new direction for the PI because his past work has not dealt with the unique mathematical formulations required for this study. ..
- Effects of Vestibular Loss on Orthostatic MechanismsScott Wood; Fiscal Year: 2004..This study will provide new information on how vestibular loss might increase susceptibility for orthostatic intolerance, and will provide new insights on otolith- autonomic human subjects. ..
- Functional similarities in renal and cochlear epitheliaPETER STEYGER; Fiscal Year: 2004....
- CERVICAL INFLUENCES ON BALANCEJoseph Furman; Fiscal Year: 2003..To address specific aim #3, postural sway will be measured in response to naso-occipital optic flow within a virtual reality environment during several yaw head-on-trunk positions. ..
- VOR adaptation/utility of saccades as rehab strategiesMichael Schubert; Fiscal Year: 2008..This is important for the long-term goals of this project, which are to determine the adaptive preferences that individuals with vestibular loss use to improve gaze stability. ..
- NEW METHOD TO IDENTIFY UNILATERAL VESTIBULAR DYSFUNCTIONRobert Peterka; Fiscal Year: 2002..Experimental results from subjects with different levels of partial unilateral vestibular loss will determine the effectiveness and reliability of the proposed new rotation test. ..
- SENSORIMOTOR INTEGRATION IN HUMAN POSTURAL CONTROLRobert Peterka; Fiscal Year: 2009..A better understanding of these active regulatory processes may lead to new rehabilitative methods and new clinical balance-function tests. ..
- Neural mechanisms of 3-D linear vestibuloocular reflexChiju Chen Huang; Fiscal Year: 2009..abstract_text> ..
- DEVELOPMENT OF VESTIBULAR NUCLEI NEURONSKENNA PEUSNER; Fiscal Year: 2005..abstract_text> ..
- MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGGWILLIAM JEFFERY; Fiscal Year: 2002..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
- NEURAL DECODING OF GRAVITO-INERTIAL CUESLIONEL ZUPAN; Fiscal Year: 2002..It is important to note that the focus of our study is to understand the neural processing causing and underlying behavioral responses, not the eye movements per se. ..
- Sensory Coding Among Semicircular Canal Afferent NeuronsLARRY HOFFMAN; Fiscal Year: 2004..These experiments will reveal new insight regarding the fundamental organization of stimulus coding in this sensory system. ..
- Neuronal Mechanisms of Opioid ActionHong Zhu; Fiscal Year: 2004..These experiments will improve our understanding of neuronal mechanisms of opioid action, which is crucial for understanding and perhaps treating of opioid addiction. ..
- Adaptation to controlled vestibular stimulationDANIEL MERFELD; Fiscal Year: 2005..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
- Multisensory Interactions Subserving Orienting BehaviorGARY PAIGE; Fiscal Year: 2002..Students and post-doctoral fellows are specifically encouraged to attend and participate, and a scholarship program will target and enhance this important aspect of the meeting. ..
- SENSORIMOTOR INTEGRATION IN SPATIAL ORIENTATIONGARY PAIGE; Fiscal Year: 2003..A thorough understanding of these functions is required to facilitate the development of specific and effective interventions that might correct, or rehabilitate, potential age or disease induced deficits. ..