otolithic membrane

Summary

Summary: A gelatinous membrane overlying the acoustic maculae of SACCULE AND UTRICLE. It contains minute crystalline particles (otoliths) of CALCIUM CARBONATE and protein on its outer surface. In response to head movement, the otoliths shift causing distortion of the vestibular hair cells which transduce nerve signals to the BRAIN for interpretation of equilibrium.

Top Publications

  1. ncbi Human 3-D aVOR with and without otolith stimulation
    Christopher J Bockisch
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, 8091 Zurich, Switzerland
    Exp Brain Res 161:358-67. 2005
  2. pmc Detection of infrasound and linear acceleration in fishes
    O Sand
    Department of Biology, The University of Oslo, Norway
    Philos Trans R Soc Lond B Biol Sci 355:1295-8. 2000
  3. ncbi Elevated CO2 enhances otolith growth in young fish
    David M Checkley
    Scripps Institution of Oceanography, University of California, San Diego, CA 92093, USA
    Science 324:1683. 2009
  4. ncbi Natal homing in a marine fish metapopulation
    S R Thorrold
    Department of Biological Sciences, Laboratory for Isotope and Trace Element Research, Old Dominion University, Norfolk, VA 23529, USA
    Science 291:297-9. 2001
  5. ncbi Otolith and canal integration on single vestibular neurons in cats
    Y Uchino
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo, 160 8402, Japan
    Exp Brain Res 164:271-85. 2005
  6. pmc Head direction cell activity in mice: robust directional signal depends on intact otolith organs
    Ryan M Yoder
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurosci 29:1061-76. 2009
  7. ncbi Bone conducted vibration selectively activates irregular primary otolithic vestibular neurons in the guinea pig
    Ian S Curthoys
    Vestibular Research Laboratory, School of Psychology, University of Sydney, Sydney, NSW, Australia
    Exp Brain Res 175:256-67. 2006
  8. ncbi Resolution of sensory ambiguities for gaze stabilization requires a second neural integrator
    Andrea M Green
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:9265-75. 2003
  9. ncbi Morphological polarizations of sensory hair cells in the three otolithic organs of a teleost fish: fluorescent imaging of ciliary bundles
    Z Lu
    Department of Biology, University of Maryland, College Park 20742 4415, USA
    Hear Res 126:47-57. 1998
  10. ncbi Form and function in the unique inner ear of a teleost: the silver perch (Bairdiella chrysoura)
    John Umar Ramcharitar
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    J Comp Neurol 475:531-9. 2004

Research Grants

  1. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
  2. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
  3. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
  4. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
  5. NEURAL MECHANISMS OF SOUND LOCALIZATION
    Zhongmin Lu; Fiscal Year: 2007
  6. Galvanic Effects on the Human Vestibuloocular Reflex
    Americo Migliaccio; Fiscal Year: 2007
  7. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
  8. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
  9. Development of a clinical test of utricular function
    Claire Gianna Poulin; Fiscal Year: 2006
  10. VESTIBULAR MECHANISMS IN THE DYNAMICS OF LOCOMOTION
    Theodore Raphan; Fiscal Year: 2006

Detail Information

Publications189 found, 100 shown here

  1. ncbi Human 3-D aVOR with and without otolith stimulation
    Christopher J Bockisch
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, 8091 Zurich, Switzerland
    Exp Brain Res 161:358-67. 2005
    ..This could be because, in humans, typical yaw head movements will stimulate the otoliths to a much lesser extent then typical pitch and roll head movements...
  2. pmc Detection of infrasound and linear acceleration in fishes
    O Sand
    Department of Biology, The University of Oslo, Norway
    Philos Trans R Soc Lond B Biol Sci 355:1295-8. 2000
    ..Sensitivity to infrasound may be a widespread ability among aquatic organisms, and has also been reported in cephalopods and crustaceans...
  3. ncbi Elevated CO2 enhances otolith growth in young fish
    David M Checkley
    Scripps Institution of Oceanography, University of California, San Diego, CA 92093, USA
    Science 324:1683. 2009
    ..We hypothesize that CO2 moves freely through the epithelium around the otoliths in young fish, accelerating otolith growth while the local pH is controlled. This is the converse of the effect commonly reported for structural biominerals...
  4. ncbi Natal homing in a marine fish metapopulation
    S R Thorrold
    Department of Biological Sciences, Laboratory for Isotope and Trace Element Research, Old Dominion University, Norfolk, VA 23529, USA
    Science 291:297-9. 2001
    ..Our findings highlight the need for consideration of spatial processes in fisheries models and have implications for the design of marine reserves in coastal regions...
  5. ncbi Otolith and canal integration on single vestibular neurons in cats
    Y Uchino
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo, 160 8402, Japan
    Exp Brain Res 164:271-85. 2005
    ..Some of the convergent neurons that receive both canal and otolith input may contribute to the short-latency pathway of the vestibulocollic reflex. The functional significance of these convergences is discussed...
  6. pmc Head direction cell activity in mice: robust directional signal depends on intact otolith organs
    Ryan M Yoder
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurosci 29:1061-76. 2009
    ..Furthermore, compared with rats, the HD signal in mice appears to be less reliably anchored to prominent environmental cues...
  7. ncbi Bone conducted vibration selectively activates irregular primary otolithic vestibular neurons in the guinea pig
    Ian S Curthoys
    Vestibular Research Laboratory, School of Psychology, University of Sydney, Sydney, NSW, Australia
    Exp Brain Res 175:256-67. 2006
    ..The BCV generates compressional and shear waves, which travel through the skull and constitute head accelerations, which are sufficient to stimulate the most sensitive otolithic receptor cells...
  8. ncbi Resolution of sensory ambiguities for gaze stabilization requires a second neural integrator
    Andrea M Green
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:9265-75. 2003
    ....
  9. ncbi Morphological polarizations of sensory hair cells in the three otolithic organs of a teleost fish: fluorescent imaging of ciliary bundles
    Z Lu
    Department of Biology, University of Maryland, College Park 20742 4415, USA
    Hear Res 126:47-57. 1998
    ..Thus, the sleeper goby's ear is morphologically capable of being a three-dimensional sound detector...
  10. ncbi Form and function in the unique inner ear of a teleost: the silver perch (Bairdiella chrysoura)
    John Umar Ramcharitar
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    J Comp Neurol 475:531-9. 2004
    ..The findings of this study support the proposal that sciaenids are excellent model species for investigating structure-function relations in the teleost auditory system...
  11. ncbi Ocular and perceptual responses to linear acceleration in microgravity: alterations in otolith function on the COSMOS and Neurolab flights
    Steven T Moore
    Mount Sinai School of Medicine, Department of Neurology, New York, NY 10029, USA
    J Vestib Res 13:377-93. 2003
    ..The findings also raise the possibility that 'artificial gravity' during the Neurolab flight counteracted adaptation of these otolith-ocular responses...
  12. ncbi Afferent synapses are present in utricular hair cells from otoconia-deficient mice
    Larry F Hoffman
    Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Box 951624, Los Angeles, CA 90095 1624, USA
    Hear Res 222:35-42. 2006
    ..These results indicate that afferent synapses within vestibular hair cells do not critically depend upon stimulus-evoked activity...
  13. ncbi Otolith deprivation induces optokinetic compensation
    Corina E Andreescu
    Department of Neuroscience, Erasmus University Medical Center Rotterdam, DR Rotterdam, The Netherlands
    J Neurophysiol 94:3487-96. 2005
    ....
  14. ncbi Correlated movement of hair bundles coupled to the otolithic membrane in the bullfrog sacculus
    C E Strimbu
    University of California, Los Angeles Department of Physics and Astronomy, Los Angeles, CA 90095, USA
    Hear Res 256:58-63. 2009
    ..To maintain the natural degree of intercell coupling, the overlying otolithic membrane was left intact atop the in vitro preparation...
  15. pmc Assessment of Meniere's disease from a radiological aspect - saccular otoconia as a cause of Meniere's disease?
    Hideo Yamane
    Department of Otorhinolaryngology, Osaka City University Graduate School of Medicine, Japan
    Acta Otolaryngol 132:1054-60. 2012
    ..These structures could be involved in the pathogenesis of MD...
  16. ncbi Orienting otolith-ocular reflexes in the rabbit during static and dynamic tilts and off-vertical axis rotation
    J Maruta
    Departments of Neurology and Physiology and Biophysics, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, New York, NY 10029, USA
    Vision Res 41:3255-70. 2001
    ..Semicircular canal input broadened the band-pass of these orienting reflexes, which would make them more appropriate when compensating for head movement during active motion...
  17. ncbi Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculus
    C E Strimbu
    University of California, Los Angeles Department of Physics and Astronomy and the California NanoSystems Institute, 475 Portola Plaza, Los Angeles, CA 90095, USA
    Hear Res 265:38-45. 2010
    ..under more natural loading conditions, innate oscillations are suppressed by the presence of the overlying otolithic membrane, indicating that hair bundles lie in the quiescent rather than the unstable regime...
  18. pmc Resting discharge patterns of macular primary afferents in otoconia-deficient mice
    T A Jones
    Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858 4353, USA
    J Assoc Res Otolaryngol 9:490-505. 2008
    ..The robust discharge rates are interesting in that they may reflect the presence of a functionally 'up-regulated' tonic excitatory process in the absence of natural sensory stimulation...
  19. pmc Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths
    R A Bergstrom
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 150:815-22. 1998
    ..This approach demonstrates the utility of chromosome deletions as reagents for mapping and characterizing mutations, particularly in situations where recombinational mapping is inadequate...
  20. ncbi Blockage of reuniting duct in Meniere's disease
    Hideo Yamane
    Department of Otorhinolaryngology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Acta Otolaryngol 130:233-9. 2010
    ....
  21. ncbi Immunohistochemical localization of two otolith matrix proteins in the otolith and inner ear of the rainbow trout, Oncorhynchus mykiss: comparative aspects between the adult inner ear and embryonic otocysts
    Emi Murayama
    Laboratory of Bioorganic Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, 113 8657 Tokyo, Japan
    Histochem Cell Biol 121:155-66. 2004
    ..These results indicate that these proteins are required as essential components for otolith formation and calcification...
  22. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
    ..These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear...
  23. ncbi First steps of otolith formation of the zebrafish: role of glycogen?
    M Pisam
    Departement de Biologie Joliot Curie, CEA Saclay, 91191 Gif sur Yvette Cedex, France
    Cell Tissue Res 310:163-8. 2002
    ..As a result, glycogen might play a key role in initiating the formation of otoliths and possibly that of other calcified tissues...
  24. ncbi Three-dimensional morphology of inner ear development in Xenopus laevis
    Michele Miller Bever
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Dev Dyn 227:422-30. 2003
    ....
  25. pmc Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish
    Jessica A Petko
    Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Dev Neurobiol 68:209-22. 2008
    ..Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths...
  26. pmc Lesions of the cerebellar nodulus and uvula in monkeys: effect on otolith-ocular reflexes
    Mark F Walker
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Prog Brain Res 171:167-72. 2008
    ....
  27. pmc Osteopontin is not critical for otoconia formation or balance function
    Xing Zhao
    Genetics Department, Boys Town National Research Hospital, Omaha, NE 68131, USA
    J Assoc Res Otolaryngol 9:191-201. 2008
    ..When compared with findings on other otoconins, the data manifest a hierarchy of importance of proteins in crystallization and indicate mechanistic similarities and differences between bone and otoconia calcification...
  28. pmc Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Rm 3902 South Building Campus Box 8103, Washington University in St Louis, School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res 1091:58-74. 2006
    ....
  29. pmc In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure
    Wenfu Lu
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 268:172-83. 2010
    ....
  30. ncbi Otolith function in cerebellar ataxia due to mutations in the calcium channel gene CACNA1A
    G Wiest
    Reed Neurological Research Center, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
    Brain 124:2407-16. 2001
    ..These findings suggest a critical role of the cerebellum in the modulation of otolith-ocular signals that is independent of motor vergence...
  31. pmc Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix
    Xing Zhao
    Genetics Department, Boys Town National Research Hospital, Omaha, NE 68131, and Center for Neuroscience, Communication Science Program, University of California at Davis 95616, USA
    Dev Biol 304:508-24. 2007
    ..Our data demonstrate the critical roles of otoconins in otoconia seeding, growth and anchoring and suggest mechanistic similarities and differences between otoconia and bone calcification...
  32. pmc Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals
    E Verpy
    Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique Unite de Recherche Associee 1968, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 96:529-34. 1999
    ..In addition, multiple isoforms generated by differential splicing were observed in different combinations during development. Based on the present results, we propose a model for the formation of the otoconia...
  33. ncbi Significance of tertiary conformation of otoconial matrix proteins - clinical implications
    Ruediger Thalmann
    Department of Otolaryngology Head and Neck Surgery, Washington University in St Louis, Missouri, USA
    Acta Otolaryngol 131:382-90. 2011
    ..Co-option of the enzyme secretory phospholipase A2 (sPLA2) and adoption of tertiary conformation are essential factors in the multifunctionality of otoconin 90 (OC90) and homologous modulators...
  34. pmc Expression, functional, and structural analysis of proteins critical for otoconia development
    Yinfang Xu
    Vestibular Neurogenetics Laboratory, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Dev Dyn 239:2659-73. 2010
    ..Analysis and modeling of Oc90 and Sc1 protein structures show common features that may be critical requirements for the otoconial matrix backbone protein. Such information will serve as the foundation for future regenerative purposes...
  35. pmc Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2
    Y Wang
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:15345-50. 1998
    ..The cloning of Oc90 will allow an examination of the role of this protein in otoconial biosynthesis and in diseases that affect the vestibular system...
  36. ncbi The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz
    S Iwasaki
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Neurophysiol 120:588-93. 2009
    ..If the n10 is due primarily to utricular activation then diseases which affect only the superior division of the vestibular nerve (SVN) should reduce or eliminate n10...
  37. ncbi Development and maintenance of otoconia: biochemical considerations
    R Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 942:162-78. 2001
    ....
  38. ncbi A critical period of ear development controlled by distinct populations of ciliated cells in the zebrafish
    B B Riley
    Department of Biology, Texas A and M University, College Station 77843 3258, USA
    Dev Biol 191:191-201. 1997
    ..5 to 24 h, and that interfering with the functions of tether cell kinocilia or beating cilia impairs otolith seeding and subsequent otolith morphogenesis...
  39. ncbi Human otolith-ocular reflexes during off-vertical axis rotation: effect of frequency on tilt-translation ambiguity and motion sickness
    Scott J Wood
    Department of Neurotology Research, Legacy Health System, Suite 303, 1225 NE 2nd Avenue, Portland, OR 97232, USA
    Neurosci Lett 323:41-4. 2002
    ..3 Hz is the result of frequency segregation of ambiguous otolith information being inadequate to distinguish between tilt and translation...
  40. ncbi Effect of acute exposure to hypergravity (GX vs. GZ) on dynamic cerebral autoregulation
    J M Serrador
    Cerebral Blood Flow Research Lab, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
    J Appl Physiol (1985) 91:1986-94. 2001
    ..We speculate that this leftward shift may have been due to vestibular activation (especially during +GX) or potentially to an adaptation to reduced cerebral perfusion pressure during +GZ...
  41. ncbi Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish
    Brian Blasiole
    Department of Pharmacology, Penn State University College of Medicine, H078, Hershey, PA 17033, USA
    Dev Biol 294:148-60. 2006
    ..Our results highlight zebrafish gene knockdown-mRNA rescue as an approach that can be used to dissect the functional properties of zebrafish and mammalian Na,K-ATPase genes...
  42. ncbi Mutations affecting development of the zebrafish inner ear and lateral line
    T T Whitfield
    ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
    Development 123:241-54. 1996
    ..At least one mutant, dog-eared, shows defects in both the ear and another placodally derived sensory system, the lateral line, while hypersensitive mutants have additional trunk lateral line organs...
  43. ncbi A review of otolith pathways to brainstem and cerebellum
    J A Buttner-Ennever
    Institute of Anatomy, Ludwig Maximilian University of Munich, Germany
    Ann N Y Acad Sci 871:51-64. 1999
    ..The graviceptive information could be channeled by the cerebellar efferents back to the vestibular and inferior olive complex, or fed into ascending pathways that would innervate the mescencephalon, the thalamus, and cerebral cortex...
  44. ncbi Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish
    B B Riley
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    J Neurobiol 43:329-37. 2000
    ..The presence of a utricular otolith in at least one inner ear is necessary and sufficient for vestibular function and survival. In contrast, saccular otoliths are dispensable for these functions...
  45. pmc Semicircular canal size determines the developmental onset of angular vestibuloocular reflexes in larval Xenopus
    François M Lambert
    Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, Centre National de Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris Descartes, 75270 Paris Cedex 06, France
    J Neurosci 28:8086-95. 2008
    ....
  46. ncbi Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae
    Emi Murayama
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, 113 8657 Tokyo, Japan
    Mech Dev 122:791-803. 2005
    ....
  47. ncbi Natal homing and connectivity in Atlantic bluefin tuna populations
    Jay R Rooker
    Department of Marine Biology, Texas A and M University, 5007 Avenue U, Galveston, TX 77551, USA
    Science 322:742-4. 2008
    ..The largest (oldest) bluefin tuna collected near the northern extent of their range in North American waters were almost exclusively of western origin, indicating that this region represents critical habitat for the western population...
  48. pmc The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear
    Jessica R Colantonio
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    Nature 457:205-9. 2009
    ..These results demonstrate a requirement for the dynein regulatory complex in vertebrates and show that cilia-driven flow is a key epigenetic factor in controlling otolith biomineralization...
  49. ncbi Otoconial agenesis in tilted mutant mice
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 122:60-70. 1998
    ..We further demonstrate that protein expression in the macular sensory epithelium is qualitatively unaltered in tilted mutant mice...
  50. ncbi Gravity receptor function in mice with graded otoconial deficiencies
    Sherri M Jones
    School of Medicine, University of Missouri, Columbia, MO 65212, USA
    Hear Res 191:34-40. 2004
    ..It also shows that behavior alone may be an unreliable indicator of the extent of gravity receptor deficits...
  51. ncbi Asymmetric integration recorded from vestibular-only cells in response to position transients
    Sam Musallam
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 88:2104-13. 2002
    ..Instead a neuron with a long membrane time constant and an excitatory postsynaptic potential duration that increases with the firing rate of the presynaptic cell can emulate the observed behavior...
  52. ncbi Orienting eye movements and nystagmus produced by translation while rotating (TWR)
    Jun Maruta
    Department of Neurology and Physiology and Biophysics, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Exp Brain Res 163:273-83. 2005
    ..We speculate that the brain may use these low amplitude rotating linear accelerations to generate eye velocities that help to orient gaze when making turns during normal locomotion...
  53. ncbi Horizontal vestibulo-ocular reflex dynamics in acute vestibular neuritis and viral labyrinthitis: evidence of otolith-canal interaction
    Raphael Maire
    Clinic of Otolaryngology Head and Neck Surgery, Neurotology Unit, University Hospital Lausanne, Lausanne, Switzerland
    Acta Otolaryngol 124:36-40. 2004
    ....
  54. ncbi Modeling gravity-dependent plasticity of the angular vestibuloocular reflex with a physiologically based neural network
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    J Neurophysiol 96:3349-61. 2006
    ..The adaptation is tuned by how the weights from otolith input to the canal-otolith-convergent neurons are adapted for a given head orientation...
  55. ncbi Why do patients with PSP fall? Evidence for abnormal otolith responses
    K Liao
    Neurology Service and Daroff Dell Osso Laboratory, Veterans Affairs Medical Center and University Hospitals, Case Western Reserve University, Cleveland, OH, USA
    Neurology 70:802-9. 2008
    ..Abnormal vestibulospinal reflexes are suspected, but the angular vestibulo-ocular reflex, which is mediated by the labyrinthine semicircular canals, survives late into the course of the disease...
  56. ncbi Dynamic effects on the subjective visual vertical after roll rotation
    Erika N Lorincz
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Neurophysiol 100:657-69. 2008
    ..This transient bias depended on both rotation and tilt direction after constant velocity rotations, but was almost abolished following constant acceleration rotations...
  57. ncbi Semicircular canal plugging shifts the frequency of spatial-temporal convergence (STC) in central vestibular neurons
    Sergei B Yakushin
    Mount Sinai School of Medicine, Neurology Dept, Box 1135, 5E 98 Street, New York, NY 10029, USA
    J Gravit Physiol 14:P71-2. 2007
  58. doi Dissociation between canal- and otolithfunction in cerebellar atrophy
    Sarah Marti
    J Neurol 255:769-71. 2008
  59. ncbi Canal and otolith contributions to visual orientation constancy during sinusoidal roll rotation
    Ronald G Kaptein
    Department of Biophysics, Radboud University Nijmegen, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    J Neurophysiol 95:1936-48. 2006
    ..Simulations showed that a linear combination of an integrated canal signal and a gravity-based signal can account for these results...
  60. ncbi Dizziness after canalith repositioning procedure for benign paroxysmal positional vertigo
    Emmanuel P Prokopakis
    Auris Nasus Larynx 34:435; author reply 437. 2007
  61. pmc Diagnostic and treatment strategy of lateral semicircular canal canalolithiasis
    G Asprella Libonati
    Unit of Audiology Vestibology and Phoniatrics, Department of Otorhinolaryngology and Head Neck Surgery, Madonna delle Grazie Hospital, Matera, Italy
    Acta Otorhinolaryngol Ital 25:277-83. 2005
    ....
  62. pmc Short-term efficacy of Epley's manoeuvre: a double-blind randomised trial
    M von Brevern
    Department of Neurology, Charite, Campus Virchow Klinkum, Berlin, Germany
    J Neurol Neurosurg Psychiatry 77:980-2. 2006
    ..Thus far, the short-term efficacy of Epley's manoeuvre for treatment of PC-BPPV is unknown...
  63. pmc Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Exp Brain Res 176:575-87. 2007
    ..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
  64. ncbi 'Bow and lean test' to determine the affected ear of horizontal canal benign paroxysmal positional vertigo
    Yun Hoon Choung
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
    Laryngoscope 116:1776-81. 2006
    ..The purpose of this study is to develop the new "bow and lean test (BLT)" to easily determine the affected ear of HSC-BPPV and evaluate its efficiency...
  65. ncbi [Exploration of the otolith function]
    M Toupet
    Centre d Explorations Fonctionnelles Oto Neurologiques, 10 rue Falguière, 75015 Paris, France
    Rev Laryngol Otol Rhinol (Bord) 126:209-15. 2005
    ..Thus a patient complaining of falling outwards is to be tested by offset rotations. A patient complaining of falling while going down in a lift is best investigated by the cortical vestibular otolith evoked potentials...
  66. ncbi Head-tilting stabilometry in patients with benign paroxysmal positional vertigo
    Kenya Inukai
    Department of Otolaryngology, Niigata University, Faculty of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Auris Nasus Larynx 35:31-5. 2008
    ..In this study, we examined changes in the parameters of stabilometry under an upright condition and head-tilt conditions in patients with BPPV...
  67. ncbi Vertical (Z-axis) acceleration alters the ocular response to linear acceleration in the rabbit
    Jun Maruta
    Department of Neurology, Mount Sinai School of Medicine, Box 1135, 1 Gustave L Levy Place, New York, NY 10029, USA
    Exp Brain Res 185:87-99. 2008
    ....
  68. ncbi Model experiments of BPPV using isolated utricle and posterior semicircular canal
    Taro Inagaki
    Department of Otolaryngology, Tokyo Medical University, Tokyo 160 0023, Japan
    Auris Nasus Larynx 33:129-34. 2006
    ..The effect of interposed otoconia in models of canalolithiasis and cupulolithiasis were also investigated using isolated posterior semicircular canal (PSC)...
  69. ncbi Self-treatment for benign paroxysmal positional vertigo of the posterior semicircular canal
    Hitosh Tanimoto
    Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Neurology 65:1299-300. 2005
    ..048). Complications occurred in 2.6% of the Epley-alone group and in 7.5% of the self-treatment group (p = 0.62)...
  70. ncbi Postural control in otolith disorders
    Dietmar Basta
    Department of Otolaryngology at UKB, Charite Medical School, Warener Str 7, D 12683 Berlin, Germany
    Hum Mov Sci 24:268-79. 2005
    ..In essence, otolith disorders evidently impair human postural control and have been possibly underestimated as a source of posttraumatic postural imbalance as yet...
  71. ncbi Otolith organ or semicircular canal stimulation induces c-fos expression in unipolar brush cells and granule cells of cat and squirrel monkey
    Gabriella Sekerkova
    Northwestern University Institute for Neuroscience, Searle 5 474, 320 E Superior Street, Chicago, IL 60611, USA
    Exp Brain Res 164:286-300. 2005
    ....
  72. ncbi The high-frequency/acceleration head heave test in detecting otolith diseases
    Paul Kessler
    Department of Otolaryngology, University of Toronto, Toronto, Ontario, Canada
    Otol Neurotol 28:896-904. 2007
    ..To investigate whether transient, high-acceleration interaural head heaves (translational vestibulo-ocular reflex [tVOR]) could aid in the diagnosis of otolith diseases...
  73. ncbi Interaction between otolith organ and semicircular canal vestibulo-ocular reflexes during eccentric rotation in humans
    Claire C Gianna-Poulin
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Exp Brain Res 185:485-95. 2008
    ..e. algebraic summation) between otolith organ and horizontal canal VORs for the generation of horizontal compensatory eye movements during head motion...
  74. ncbi Responses of monkey vestibular-only neurons to translation and angular rotation
    Wu Zhou
    Department of Otolaryngology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48105, USA
    J Neurophysiol 96:2915-30. 2006
    ..Significantly, recent theoretical models have predicted neurons with discharge patterns similar to those of low- and high-sensitivity neurons...
  75. ncbi Efficacy of the Epley maneuver for posterior canal BPPV: a long-term, controlled study of 81 patients
    Wietske Richard
    Department of Otorhinolaryngology, Gelre Hospital, Apeldoorn, The Netherlands
    Ear Nose Throat J 84:22-5. 2005
    ..We conclude that the Epley maneuver provides effective and long-term control of symptoms in patients with BPPV...
  76. ncbi Vestibulo-ocular function in anxiety disorders
    Joseph M Furman
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Vestib Res 16:209-15. 2006
    ..Excessive SMD and height phobia seem to have a mitigating effect on abnormal vestibular sensitivity, possibly via a down-weighting of central vestibular pathways...
  77. ncbi Otolith-ocular responses in patients with surgically confirmed unilateral peripheral vestibular loss
    Joseph M Furman
    Department of Otolaryngology, University of Pittsburgh, PA, USA
    J Vestib Res 13:143-51. 2003
    ..These results have clinical implications for the management of patients with unilateral vestibular loss and provide insights into the process of vestibular compensation especially with respect to the otolith-ocular reflex...
  78. ncbi Canal-otolith interaction in the fastigial nucleus of the alert monkey
    C Siebold
    Department of Neurology, Ludwig-Maximilians University, Munich, Germany
    Exp Brain Res 136:169-78. 2001
    ..The large variety of response types allows these neurons to participate in multiple tasks of vestibulospinal movement control...
  79. ncbi [Diagnosis and treatment of horizontal canal benign paroxysmal positional vertigo]
    G Xing
    Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 36:28-30. 2001
    ..CONCLUSION: HC-BPPV is different from PC-BPPV and other vertiginous diseases in typical presentations and positional testing results. The barbecue rotation is a successful method for curing the disorder...
  80. ncbi A general framework for neurobiological modeling: an application to the vestibular system
    Chris Eliasmith
    Department of Philosophy, Department of Systems Design Engineering, University of Waterloo, Waterloo, Ont, Canada
    Neurocomputing 44:1071-6. 2002
    ..The model is constructed using general principles of neurobiological simulation (J. Neurophys. 84 (2000) 2113)...
  81. ncbi Human vestibular memory studied via measurement of the subjective horizontal during gondola centrifugation
    Arne Tribukait
    Department of Audiology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Neurobiol Learn Mem 80:1-10. 2003
    ..Further, the SVH seems to be dependent on two different mechanisms related to semicircular canal stimulation...
  82. ncbi The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL/6 mice
    Christopher G Harrod
    Northwestern University, Department of Physiology and Institute for Neuroscience, 303 East Chicago Avenue, M211, Chicago, IL 60611, USA
    Brain Res 972:75-83. 2003
    ..Because semicircular canals are normal in het mice, we conclude that central neurons of the canal VOR are dependent on otolith organ signals for normal performance...
  83. ncbi 3D eye movement analysis during sinusoidal off vertical axis rotation in human subjects
    Y Koizumi
    Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
    Acta Otolaryngol 123:121-8. 2003
    ..In order to investigate these characteristics, we performed a 3D analysis of eye movements induced by human sinusoidal s-OVAR, and compared the result with that of eye movements induced by constant c-OVAR...
  84. ncbi Response properties of Y group neurons to crossed otolith inputs in the cat
    Y S Chan
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, P R China
    Neuroreport 14:729-33. 2003
    ..The best response orientations of one-dimensional and two-dimensional neurons were found predominantly along the antero-posterior direction, thus providing a spatial framework for the otolithic reflexes...
  85. ncbi Effect of semicircular canal stimulation on the perception of the visual vertical
    Marousa Pavlou
    Academic Department of Neuro Otology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London W6 8RF, United Kingdom
    J Neurophysiol 90:622-30. 2003
    ....
  86. ncbi Benign paroxysmal positional vertigo: some recent advances
    Adolfo M Bronstein
    Curr Opin Neurol 16:1-3. 2003
  87. ncbi Adaptive plasticity in the otolith-ocular reflex
    Izumi Koizuka
    Department of Otolaryngology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki City, 216 8511, Kanagawa, Japan
    Auris Nasus Larynx 30:S3-6. 2003
    ..We believe that the ScOR and the OOR share common neural pathways in such a way that a change in the synaptic efficacy of one pathway is accompanied by a change in the other...
  88. ncbi Neural processing of gravito-inertial cues in humans. IV. Influence of visual rotational cues during roll optokinetic stimuli
    L H Zupan
    Jenks Vestibular Physiology Laboratory, Boston 02114, USA
    J Neurophysiol 89:390-400. 2003
    ..Furthermore, as predicted, the horizontal response in the dark was larger for Tilters (n = 5) than for Non-Tilters (n = 12)...
  89. ncbi Eye movements during multi-axis whole-body rotations
    Christopher J Bockisch
    Department of Neurology, University Hospital Zurich, Switzerland
    J Neurophysiol 89:355-66. 2003
    ..Our study, supported by other experiments, also indicates that static otolith signals exhibit considerably smaller effects on eye movements in humans than in monkeys...
  90. ncbi Orientation of Listing's plane during static tilt in young and older human subjects
    Joseph M Furman
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, EEI Bldg, Ste 500, Pittsburgh, PA 15213, USA
    Vision Res 43:67-76. 2003
    ..The only obvious difference between the two age groups was that the "thickness" of Listing's plane was greater in the older subjects. This suggests that aging has a small, but definite, influence on Listing's law...
  91. ncbi Linearity of canal-otolith interaction during eccentric rotation in humans
    S H Seidman
    Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Exp Brain Res 147:29-37. 2002
    ....
  92. ncbi Using sensory weighting to model the influence of canal, otolith and visual cues on spatial orientation and eye movements
    L H Zupan
    Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston 02114, USA
    Biol Cybern 86:209-30. 2002
    ..g., centered and eccentric yaw rotation about an earth-vertical axis, yaw rotation about an earth-horizontal axis) and with visual cues (e.g., stabilized visual stimulation or optokinetic stimulation)...
  93. ncbi The relation of motion sickness to the spatial-temporal properties of velocity storage
    Mingjia Dai
    Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, New York, NY 10029, USA
    Exp Brain Res 151:173-89. 2003
    ....
  94. ncbi Model experiment of benign paroxysmal positional vertigo mechanism using the whole membranous labyrinth
    Koji Otsuka
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 123:515-8. 2003
    ..A vibratory stimulus was able to detach the otoconia from the utricle, suggesting that mechanical insult could be a possible etiology of BPPV...
  95. ncbi Static and dynamic vestibulo-cervico-ocular responses after prolonged exposure to microgravity
    L N Kornilova
    RF SRC Institute of Biomedical Problems, Russian Academy of Sciences, Russia
    J Vestib Res 17:217-26. 2007
    ..However, the suppressed otolith functioning in the period of readaptation to the normal gravity was, as a rule, accompanied by an exaggerated vestibular reactivity...
  96. ncbi Signal processing of semicircular canal and otolith signals in the vestibular nuclei during passive and active head movements
    Robert A McCrea
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    Ann N Y Acad Sci 1004:169-82. 2003
    ..Several specific examples of how sensory information related to passive and active head movements is transformed in the vestibular nuclei are discussed...
  97. ncbi Nonlinear nystagmus processing causes torsional VOR nonlinearity
    E Schneider
    Ludwig Maximilians University, Department of Neurology and Center for Sensorimotor Research, Munich, Germany
    Ann N Y Acad Sci 1004:500-5. 2003
    ..This method proved to be suitable for determining whether nonlinear processing of nystagmus frequency is responsible for the TVOR nonlinearity...
  98. ncbi Vestibulo-ocular physiology underlying vestibular hypofunction
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 710 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Phys Ther 84:373-85. 2004
    ..The purposes of this article are to review the anatomy and physiology of the vestibular system and to describe the neurophysiological mechanisms responsible for the vestibulo-ocular abnormalities in patients with vestibular hypofunction...
  99. ncbi Dynamic modulation of ocular orientation during visually guided saccades and smooth-pursuit eye movements
    Bernhard J M Hess
    Department of Neurology, Zurich University Hospital, Switzerland
    Ann N Y Acad Sci 1004:132-41. 2003
    ..It is suggested that this graviceptive control of eye orientation facilitates rapid visual spatial orientation during motion...
  100. ncbi Direction specific error patterns during continuous tracking of the subjective visual vertical
    S Keusch
    Department of Neurology, University of Zurich, 8091 Zurich, Switzerland
    Exp Brain Res 155:283-90. 2004
    ..We conclude that the central processing underlying these perceptual tracking responses requires, besides the otolith input, information from the vertical semicircular canals...
  101. ncbi [Habituation of horizontal eye nystagmus in pigeon during alternation of central and eccentric rotations]
    Iu K Stolbkov
    I P Pavlov Institute of Physiology, Russian Acad Sci, 199034, St Petersburg, Nab Makarova, 6, Russia
    Ross Fiziol Zh Im I M Sechenova 89:738-48. 2003
    ..These variations were not random (probability, > 95%)...

Research Grants42

  1. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
    ..The design of these studies will increase our understanding of how the vestibular system contributes to orthostatic blood pressure regulation in humans. ..
  3. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
    ....
  4. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. NEURAL MECHANISMS OF SOUND LOCALIZATION
    Zhongmin Lu; Fiscal Year: 2007
    ..Single-cell recording will determine if there are neurons in the medulla and/or midbrain of the goldfish that encode specific timing differences between particle motion and pressure inputs. ..
  6. Galvanic Effects on the Human Vestibuloocular Reflex
    Americo Migliaccio; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  8. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ....
  9. Development of a clinical test of utricular function
    Claire Gianna Poulin; Fiscal Year: 2006
    ..Recommendations for the use of eccentric rotation as a clinical utricular test will be provided as a result of the proposed experiments. ..
  10. VESTIBULAR MECHANISMS IN THE DYNAMICS OF LOCOMOTION
    Theodore Raphan; Fiscal Year: 2006
    ....
  11. Improved Search Coil Method for Measuring Eye Movements
    Mark Shelhamer; Fiscal Year: 2007
    ..abstract_text> ..
  12. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..abstract_text> ..
  13. MULTIDIMENSIONAL DYNAMIC OF THE VESTIBULO OCULAR REFLEX
    Theodore Raphan; Fiscal Year: 2008
    ..When the study is completed, we will have a quantitative model of how the vestibular system contributes to maintenance of binocular gaze stability while moving. ..
  14. HAIR CELL RESPONSES TO OTOTOXIC DRUGS
    PETER STEYGER; Fiscal Year: 2007
    ..This may lead to new co-therapeutic treatments with aminoglycosides and (cellular) aminoglycoside-uptake inhibitors against a wider range of bacterial infections. ..
  15. A gene-trap screen for hearing and balance
    DONNA FEKETE; Fiscal Year: 2008
    ..Our long-term goal is to determine whether any of the newly discovered hearing-related genes in zebrafish also correspond to genes underlying congenital deafness in humans. [unreadable] [unreadable] [unreadable]..
  16. EFFERENT INNERVATION OF IDENTIFIED VESTIBULAR AFFERENTS
    Anna Lysakowski; Fiscal Year: 2008
    ..The intent is to produce a body of morphological, neurochemical and cell biological knowledge from which physiologically and pharmacologically testable hypotheses can be derived. [unreadable] [unreadable] [unreadable]..
  17. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  18. VESTIBULO-OCULAR FUNCTION IN THE ELDERLY
    Joseph Furman; Fiscal Year: 2009
    ..Taken together, these studies will provide essential information regarding the influence of aging on several specific aspects of balance and thus may have practical implications regarding the management of age-related loss of balance. ..
  19. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    Kenna D Peusner; Fiscal Year: 2010
    ..As we learn more about the pathology induced by vestibular deafferentation at the level of vestibular nuclei neurons, effective therapies can be targeted selectively to improve the clinical management of patients with balance disorders. ..
  20. ENCODING OF VOCAL SIGNALS IN THE AUDITORY SYSTEM
    Andrew H Bass; Fiscal Year: 2011
    ..with auditory; neuropathy/dys-synchrony.. '-.'...... ..
  21. Scaling in Reflexive and Volitional Eye Movements
    Mark Shelhamer; Fiscal Year: 2006
    ..Since scaling changes with pathology, new means to assess vestibular or oculomotor pathology may result. ..
  22. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  23. FUNCTION AND PLACTICITY IN CANAL OTOLITH INTERACTIONS
    GARY PAIGE; Fiscal Year: 2002
    ..Novel techniques will be explored, and specific endorgan lesions will be employed to directly assess the origin o VOR behaviors and elucidate processes that restore function. ..
  24. GDNF Protection in the Inner Ear
    Yehoash Raphael; Fiscal Year: 2005
    ..The data we propose to generate will enhance our understanding of the mechanisms of action of GDNF in normal and injured inner ear epithelia, knowledge that may eventually lead to better clinical treatments ..
  25. Methylphenidate & gene expression in the rat brain.
    JOAN BAIZER; Fiscal Year: 2004
    ..abstract_text> ..
  26. Pilot Studies in Adaptation in Parabolic Flight
    Mark Shelhamer; Fiscal Year: 2004
    ..abstract_text> ..
  27. Phase Transition Models of Oculomotor Control
    Mark Shelhamer; Fiscal Year: 2003
    ..The work represents a new direction for the PI because his past work has not dealt with the unique mathematical formulations required for this study. ..
  28. Effects of Vestibular Loss on Orthostatic Mechanisms
    Scott Wood; Fiscal Year: 2004
    ..This study will provide new information on how vestibular loss might increase susceptibility for orthostatic intolerance, and will provide new insights on otolith- autonomic human subjects. ..
  29. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    ....
  30. CERVICAL INFLUENCES ON BALANCE
    Joseph Furman; Fiscal Year: 2003
    ..To address specific aim #3, postural sway will be measured in response to naso-occipital optic flow within a virtual reality environment during several yaw head-on-trunk positions. ..
  31. VOR adaptation/utility of saccades as rehab strategies
    Michael Schubert; Fiscal Year: 2008
    ..This is important for the long-term goals of this project, which are to determine the adaptive preferences that individuals with vestibular loss use to improve gaze stability. ..
  32. NEW METHOD TO IDENTIFY UNILATERAL VESTIBULAR DYSFUNCTION
    Robert Peterka; Fiscal Year: 2002
    ..Experimental results from subjects with different levels of partial unilateral vestibular loss will determine the effectiveness and reliability of the proposed new rotation test. ..
  33. SENSORIMOTOR INTEGRATION IN HUMAN POSTURAL CONTROL
    Robert Peterka; Fiscal Year: 2009
    ..A better understanding of these active regulatory processes may lead to new rehabilitative methods and new clinical balance-function tests. ..
  34. Neural mechanisms of 3-D linear vestibuloocular reflex
    Chiju Chen Huang; Fiscal Year: 2009
    ..abstract_text> ..
  35. DEVELOPMENT OF VESTIBULAR NUCLEI NEURONS
    KENNA PEUSNER; Fiscal Year: 2005
    ..abstract_text> ..
  36. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2002
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  37. NEURAL DECODING OF GRAVITO-INERTIAL CUES
    LIONEL ZUPAN; Fiscal Year: 2002
    ..It is important to note that the focus of our study is to understand the neural processing causing and underlying behavioral responses, not the eye movements per se. ..
  38. Sensory Coding Among Semicircular Canal Afferent Neurons
    LARRY HOFFMAN; Fiscal Year: 2004
    ..These experiments will reveal new insight regarding the fundamental organization of stimulus coding in this sensory system. ..
  39. Neuronal Mechanisms of Opioid Action
    Hong Zhu; Fiscal Year: 2004
    ..These experiments will improve our understanding of neuronal mechanisms of opioid action, which is crucial for understanding and perhaps treating of opioid addiction. ..
  40. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  41. Multisensory Interactions Subserving Orienting Behavior
    GARY PAIGE; Fiscal Year: 2002
    ..Students and post-doctoral fellows are specifically encouraged to attend and participate, and a scholarship program will target and enhance this important aspect of the meeting. ..
  42. SENSORIMOTOR INTEGRATION IN SPATIAL ORIENTATION
    GARY PAIGE; Fiscal Year: 2003
    ..A thorough understanding of these functions is required to facilitate the development of specific and effective interventions that might correct, or rehabilitate, potential age or disease induced deficits. ..