acoustic maculae

Summary

Summary: Thickened areas of the saccule and utricle where the termination of the vestibular nerve occurs.

Top Publications

  1. pmc ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin
    Patrick J Antonellis
    Departments of Otolaryngology Head and Neck Surgery, Biology, Genetics and Genome Sciences, and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44016, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, and Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065
    J Neurosci 34:305-12. 2014
  2. pmc Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
    Ru Zhang
    Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fen Yang Road, Shanghai 200031, China
    Hear Res 298:49-59. 2013
  3. ncbi Receptors for glucocorticoids in the human inner ear
    K E Rarey
    Department of Anatomy, College of Medicine, University of Florida, Gainesville, 32610, USA
    Otolaryngol Head Neck Surg 115:38-41. 1996
  4. ncbi [Isolated functional loss of the lateral semicircular canal in vestibular neuritis]
    A Blödow
    HNO Klinik, Helios Klinikum Berlin Buch, Schwanebecker Chaussee 50, 13125, Berlin, Deutschland
    HNO 61:46-51. 2013
  5. ncbi Localization of vesicular glutamate transporters in the peripheral vestibular system of rat
    Yuan Wang
    Department of Anatomy and K K Leung Brain Research Centre, China
    Neurosci Bull 23:175-9. 2007
  6. ncbi Age-related differences in parameters of vestibular evoked myogenic potentials
    Sun Kyu Lee
    Department of Otolaryngology and Head and Neck Surgery, College of Medicine, Kyunghee University, Seoul, Korea
    Acta Otolaryngol 128:66-72. 2008
  7. ncbi Attachment of the utricular and saccular maculae to the temporal bone
    Hilal Uzun-Coruhlu
    University of Sydney, Australian Key Centre for Microscopy and Microanalysis, Madsen Building, F09, The University of Sydney, NSW 2006, Australia
    Hear Res 233:77-85. 2007
  8. ncbi A place principle for vertigo
    Richard R Gacek
    Department of Otolaryngology, Head and Neck Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Auris Nasus Larynx 35:1-10. 2008
  9. ncbi Architecture of the mouse utricle: macular organization and hair bundle heights
    A Li
    Department of Biological Sciences and Neuroscience Program, Ohio University, Athens, OH 45701, USA
    J Neurophysiol 99:718-33. 2008
  10. ncbi Zebrafish pax5 regulates development of the utricular macula and vestibular function
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 235:3026-38. 2006

Research Grants

  1. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
  2. Adenylyl Cyclase Signaling in Ear Sensory Eipthelia
    MARIAN DRESCHER; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications61

  1. pmc ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin
    Patrick J Antonellis
    Departments of Otolaryngology Head and Neck Surgery, Biology, Genetics and Genome Sciences, and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44016, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, and Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065
    J Neurosci 34:305-12. 2014
    ..These observations are consistent with ACF7 being a linker protein, which may shape the cytoskeleton of the hair cell early during hair-bundle genesis...
  2. pmc Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
    Ru Zhang
    Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fen Yang Road, Shanghai 200031, China
    Hear Res 298:49-59. 2013
    ..Transtympanic administration of gentamicin is effective for treating patients with intractable vertigo. This study explored the spatial and temporal distribution of gentamicin in vestibular end-organs after transtympanic administration...
  3. ncbi Receptors for glucocorticoids in the human inner ear
    K E Rarey
    Department of Anatomy, College of Medicine, University of Florida, Gainesville, 32610, USA
    Otolaryngol Head Neck Surg 115:38-41. 1996
    ....
  4. ncbi [Isolated functional loss of the lateral semicircular canal in vestibular neuritis]
    A Blödow
    HNO Klinik, Helios Klinikum Berlin Buch, Schwanebecker Chaussee 50, 13125, Berlin, Deutschland
    HNO 61:46-51. 2013
    ....
  5. ncbi Localization of vesicular glutamate transporters in the peripheral vestibular system of rat
    Yuan Wang
    Department of Anatomy and K K Leung Brain Research Centre, China
    Neurosci Bull 23:175-9. 2007
    ..To examine the vesicular glutamate transporters (VGluTs: VGluT1-VGluT3) in the peripheral vestibular system...
  6. ncbi Age-related differences in parameters of vestibular evoked myogenic potentials
    Sun Kyu Lee
    Department of Otolaryngology and Head and Neck Surgery, College of Medicine, Kyunghee University, Seoul, Korea
    Acta Otolaryngol 128:66-72. 2008
    ..These findings indicate that age should be taken into account when interpreting VEMP results. It is also important to determine a standard method for performing VEMP and a universal index for comparison among laboratories...
  7. ncbi Attachment of the utricular and saccular maculae to the temporal bone
    Hilal Uzun-Coruhlu
    University of Sydney, Australian Key Centre for Microscopy and Microanalysis, Madsen Building, F09, The University of Sydney, NSW 2006, Australia
    Hear Res 233:77-85. 2007
    ....
  8. ncbi A place principle for vertigo
    Richard R Gacek
    Department of Otolaryngology, Head and Neck Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Auris Nasus Larynx 35:1-10. 2008
    ..To provide a road map of the vestibular labyrinth and its innervation leading to a place principle for different forms of vertigo...
  9. ncbi Architecture of the mouse utricle: macular organization and hair bundle heights
    A Li
    Department of Biological Sciences and Neuroscience Program, Ohio University, Athens, OH 45701, USA
    J Neurophysiol 99:718-33. 2008
    ..These low KS ratios suggest that bundle stiffness is greater in the striola than in the extrastriola...
  10. ncbi Zebrafish pax5 regulates development of the utricular macula and vestibular function
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 235:3026-38. 2006
    ..Thus, pax5 works in conjunction with fgf3 and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function...
  11. ncbi Morphometry of otoliths in chicken macula lagena
    Chang Xiang Li
    Auditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei
    Neurosci Lett 404:83-6. 2006
    ..The results suggest that otoliths in the macula lagena and those in the vestibular system of bird's inner ear have similar physical properties and may play a similar role in sensing gravitational and acceleration signals...
  12. ncbi Regeneration of vestibular otolith afferents after ototoxic damage
    Mridha Zakir
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:2881-93. 2006
    ..If true, adaptive plasticity in the central neural processing of motion information would be necessitated, because it is known that many vestibular-related behaviors fully recover during regeneration...
  13. ncbi Stereological study of postnatal development in the mouse utricular macula
    Mette Kirkegaard
    Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, Denmark
    J Comp Neurol 492:132-44. 2005
    ..There was no change in the total number of cells and no decline in the number of hair cells within the time period studied...
  14. ncbi Hair bundle heights in the utricle: differences between macular locations and hair cell types
    Jingbing Xue
    Department of Biological Sciences, Irvine Hall, Ohio University, Athens, OH 45701, USA
    J Neurophysiol 95:171-86. 2006
    ....
  15. ncbi No correlation between multilamellar bodies in the inner ear and further organs of mutant (backstroke, bks) and wildtype zebrafish embryos
    R Anken
    Zoological Institute, University of Stuttgart Hohenheim, Stuttgart, Germany
    Adv Space Res 33:1411-5. 2004
    ..Their presence more likely indicates cellular remodelling processes of hitherto unknown significance...
  16. ncbi Extremely elongated mitochondria in ionocytes of the saccular epithelium of a teleost, Oreochromis mossambicus (Cichlidae)
    K Muders
    Zoological Institute, University of Stuttgart Hohenheim, Stuttgart, Germany
    Adv Space Res 33:1406-10. 2004
    ....
  17. ncbi Ultrastructural changes in otoconia of osteoporotic rats
    Dominique Vibert
    Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, University of Bern, Bern, Switzerland
    Audiol Neurootol 13:293-301. 2008
    ..The possible pathophysiological mechanisms which support the relationship between recurrent BPPV in women and the disturbance of the calcium metabolism of osteopenia/osteoporosis are debated...
  18. pmc Resting discharge patterns of macular primary afferents in otoconia-deficient mice
    T A Jones
    Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858 4353, USA
    J Assoc Res Otolaryngol 9:490-505. 2008
    ..The robust discharge rates are interesting in that they may reflect the presence of a functionally 'up-regulated' tonic excitatory process in the absence of natural sensory stimulation...
  19. pmc Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears
    Maria Sol Collado
    Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e23861. 2011
    ..e., the cellular thresholds for shape changes that promote S-phase, were evident and may be particularly influential in the responses to hair cell losses in vivo...
  20. pmc An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells
    M J Drescher
    Laboratory of Bio Otology, Department of Otolaryngology, Wayne State University School of Medicine, Lande Medical Research Building, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neuroscience 171:1054-74. 2010
    ....
  21. pmc Mefloquine damage vestibular hair cells in organotypic cultures
    Dongzhen Yu
    Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, Buffalo, NY 14214, USA
    Neurotox Res 20:51-8. 2011
    ..These results indicate that mefloquine can induce significant hair cell degeneration in the postnatal rat utricle and that mefloquine-induced hair cell death is initiated by both caspase-8 and caspase-9...
  22. pmc Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma
    Gail Ishiyama
    Neurology Department, Division of Head and Neck, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Cell Tissue Res 340:407-19. 2010
    ..Changes in AQP4 (decreased) and AQP6 (increased) expression in Meniere's disease specimens suggest that the supporting cell might be a cellular target...
  23. ncbi The utricular macula: qualitative and quantitative analysis using 3-T imaging
    Lorraine M Ash
    Division of Neuroradiology, Department of Radiology, University of Michigan Health Systems, Ann Arbor, MI 48109 0030, USA
    J Comput Assist Tomogr 34:93-7. 2010
    ..To identify and measure the mean size of the utricular macula using 3-T imaging...
  24. ncbi Model experiments of otoconia stability after canalith repositioning procedure of BPPV
    Koji Otsuka
    Department of Otolaryngology, Tokyo Medical University, Japan
    Acta Otolaryngol 130:804-9. 2010
    ..Postural restrictions are probably not necessary after the canalith repositioning procedure (CRP)...
  25. ncbi Adenovector-mediated hair cell regeneration is affected by promoter type
    Mark Praetorius
    Department of Otolaryngology, University of Heidelberg, Heidelberg, Germany
    Acta Otolaryngol 130:215-22. 2010
    ..Replacement of vestibular hair cells induced by atoh1 driven by the tissue-specific GFAP promoter was significantly more efficient than use of the cBA or hCMV promoter...
  26. ncbi Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin
    Karine Faucher
    ENT Department, Institute of Clinical Medicine, University of Tromsø, Norway
    Int J Audiol 48:456-64. 2009
    ..These observations suggest that the macula sacculi of Atlantic cod can regenerate towards a near-complete functional and ultrastructural recovery within 17-21 days following ototoxic gentamicin treatment...
  27. ncbi Quantitative cellular level analysis of mitochondrial DNA 3243A > G mutations in individual tissues from the archival temporal bones of a MELAS patient
    Hiroko Koda
    Department of Otolaryngology, Tokyo Metropolitan Health and Medical Treatment Corporation Okubo Hospital, Tokyo
    Acta Otolaryngol 130:344-50. 2010
    ....
  28. ncbi Analysis of magnetic elements in otoliths of the macula lagena in homing pigeons with inductively coupled plasma mass spectrometry
    Ying Zhao
    Auditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Neurosci Bull 25:101-8. 2009
    ..To clarify this issue, we carried out a study to determine whether or not otoliths in the lagena of homing pigeons are richer in magnetic elements than those in the saccule and the utricle...
  29. ncbi [Functional anatomy of the vestibular nerve]
    C Tilikete
    Université Lyon I, Lyon, France
    Neurochirurgie 55:127-31. 2009
    ..Therefore, vestibular syndrome resulting from neurovascular compression syndrome of the VIIIth nerve may exist, but it is very difficult to prove using radiological imagery...
  30. ncbi Values for macular perimetry using the MP-1 microperimeter in normal subjects
    Vinay A Shah
    University of Missouri Kansas City, Kansas City, MO, USA
    Ophthalmic Res 41:9-13. 2009
    ..To establish values for the fixation pattern and macular sensitivity to light in healthy subjects using the MP-1 microperimeter (Nideck Technologies, Vigonza, Italy)...
  31. ncbi Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1
    Vanessa Besson
    CNRS IEM FRE2815, Institut de Transgénose, 3B rue de la Ferollerie, 45071 Orleans Cedex 2, France
    Biol Cell 97:787-98. 2005
    ..Due to the similarity between the human and mouse vestibular apparatus, the analysis of mutant mouse is a valuable strategy aiming to identify genes involved in the control of balance and movement...
  32. ncbi Assessment of differential gene expression in vestibular epithelial cell types using microarray analysis
    Ricardo Cristobal
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226 3596, USA
    Brain Res Mol Brain Res 133:19-36. 2005
    ....
  33. ncbi Central projections of the utricular nerve in the gerbil
    Shawn D Newlands
    Department of Otolaryngology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Comp Neurol 452:11-23. 2002
    ..This study did not produce complete filling of individual afferent collateral projections into the cerebellar cortex...
  34. pmc Age-related blood flow and capillary changes in the rat utricular macula: a quantitative stereological and microsphere study
    Michael J Lyon
    Department of Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Assoc Res Otolaryngol 3:167-73. 2002
    ..41) or L(cap) (Y = 9.47 mm, O = 8.96 mm; P = 0.49). These age-related vascular changes are likely to have a significant impact on utricular physiological and thus, dysequilibrium...
  35. ncbi Sciaenid inner ears: a study in diversity
    J Ramcharitar
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Brain Behav Evol 58:152-62. 2001
    ....
  36. ncbi Three-dimensional analysis of morphological aspects of the human saccular macula
    H Naganuma
    Department of Otorhinolaryngology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Ann Otol Rhinol Laryngol 110:1017-24. 2001
    ..It is thought that this shape is necessary in order for the saccular macula to detect wide-range linear acceleration...
  37. ncbi Complex vestibular macular anatomical relationships need a synthetic approach
    M D Ross
    Telemedicine Program, University of New Mexico, Health Sciences Center, Albuquerque, New Mexico, USA
    Acta Otolaryngol Suppl 545:25-8. 2001
    ..This report emphasizes that a synthetic approach is critical to understanding how maculae function and the kind of information they conduct to the brain...
  38. ncbi The inner ear macular sensory epithelia of the Daubenton's bat
    M Kirkegaard
    Department of Zoophysiology, University of Aarhus, DK-8000 Aarhus C, Denmark
    J Comp Neurol 438:433-44. 2001
    ..A number of immature as well as apoptotic hair cells were observed. It is suggested that a continuous production of new hair cells takes place in mature individuals, probably based on transdifferentiation of supporting cells...
  39. ncbi [Squirrel monkey--an ideal primate (correction of prmate) model of space physiology]
    K Matsunami
    Institute of Equilibrium Research, Gifu University School of Medicine, Japan
    Biol Sci Space 11:87-111. 1997
    ..Finally the experiments in space revealed the presence of at least two origins of caloric nystagmus, that is, attributable to convection and non-convection current of the endolymphatic fluid...
  40. ncbi Comparison and evolution of the lagena in various animal species
    Y Harada
    Hiroshima University, Higashi-Hiroshima, Japan
    Acta Otolaryngol 121:355-63. 2001
    ..In future it will be very interesting and useful to identify this extinct animal using DNA techniques...
  41. ncbi Vesicular bodies in fish maculae are artifacts not contributing to otolith growth
    M Ibsch
    Zoological Institute, University of Stuttgart-Hohenheim, Garbenstr. 30, D-70593 Stuttgart, Germany
    Hear Res 153:80-90. 2001
    ..Thus, the protein matrix of otoliths (and possibly that of statoliths in higher vertebrates) is rather provided by secretion processes than by the release of vesicles...
  42. ncbi Roles of beta-catenin in inner ear development in rat embryos
    M Matsuda
    Department of Embryology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
    Anat Embryol (Berl) 202:39-48. 2000
    ..These results suggested that beta-catenin plays a role in cell proliferation in the otic placodes and in differentiation of acoustic neurons within the acoustic neural crest complex...
  43. ncbi Study of the gerbil utricular macula following treatment with gentamicin, by use of bromodeoxyuridine and calmodulin immunohistochemical labelling
    Y Ogata
    Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan
    Hear Res 133:53-60. 1999
    ..Our results suggest that the bromodeoxyuridine-labelled cells could not be positively identified as hair cells based on immunohistochemical labelling for calmodulin...
  44. ncbi The planes of the utricular and saccular maculae of the guinea pig
    I S Curthoys
    Department of Psychology, University of Sydney, New South Wales, Australia
    Ann N Y Acad Sci 871:27-34. 1999
    ..The x, y, z coordinates of these points were plotted using a three-dimensional plotting program. Both maculae have pronounced curvature so that dorsoventral shear forces will stimulate regions of both the utricular and saccular maculae...
  45. ncbi Evidence of a sensory processing unit in the mammalian macula
    T C Chimento
    NASA Ames Research Center, Life Sciences Biocomputation Center, Moffett Field, California 94035 1000, USA
    Ann N Y Acad Sci 781:196-212. 1996
    ....
  46. ncbi Extracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: molecular and structural diversity
    Richard J Goodyear
    School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom
    J Neurobiol 53:212-27. 2002
    ....
  47. ncbi Susceptibility to abnormal (kinetotic) swimming fish correlates with inner ear carbonic anhydrase-reactivity
    Marion Beier
    Zoological Institute, University of Stuttgart Hohenheim, Garbenstr 30, D 70593 Stuttgart, Germany
    Neurosci Lett 335:17-20. 2002
    ....
  48. ncbi Morphological characteristics of the human macula sacculi
    Arne Tribukait
    Department of Audiology, Karolinska Hospital, Stockholm, Sweden
    Audiol Neurootol 10:90-6. 2005
    ..4 +/- 4.7. As regards the shape of the macula, there was a large interindividual variability. The findings are discussed, taking into consideration comparative anatomy as well as spatial orientation...
  49. ncbi Hypergravity decreases carbonic anhydrase-reactivity in inner ear maculae of fish
    Ralf H Anken
    Zoological Institute, University of Stuttgart Hohenheim, D 70593, Germany
    J Exp Zool A Comp Exp Biol 301:815-9. 2004
    ..The result is in complete agreement with previous studies indicating that a regulatory mechanism, which adjusts otolith size and asymmetry towards the gravity vector, acts via activation/deactivation of macular CA...
  50. ncbi Hyper-vision in a patient with central and paracentral vision loss reflects cortical reorganization
    Clara Casco
    Dipartimento di Psicologia Generale, Universita di Padova, Italy
    Vis Neurosci 20:501-10. 2003
    ....
  51. ncbi Histology of the utricle in kinetotically swimming fish: a parabolic aircraft flight study
    Annegret Bäuerle
    Zoological Institute, University of Stuttgart Hohenheim, Stuttgart, Germany
    Acta Otolaryngol 124:19-22. 2004
    ....
  52. ncbi Morphometry of otoconia in the utricle and saccule of developing Japanese quail
    J David Dickman
    Department of Otolaryngology, Washington University, 660 South Euclid, St Louis, MO 63110, USA
    Hear Res 188:89-103. 2004
    ..In the utricular macula, large otoconia were concentrated in the lateral regions of the epithelium. In contrast, otoconia of various sizes were distributed uniformly across the surface of the saccular macula...
  53. ncbi The evolution of concepts of vestibular peripheral information processing: toward the dynamic, adaptive, parallel processing macular model
    Muriel D Ross
    Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA
    Acta Otolaryngol 123:784-94. 2003
    ....
  54. ncbi Localization of the two constitutively expressed nitric oxide synthase isoforms (nNOS and eNOS) in the same cell types in the saccule maculae of the frog Rana pipiens by immunoelectron microscopy: evidence for a back-up system?
    Ulf Rüdiger Heinrich
    ENT Department, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, D 55131 Mainz, Germany
    J Electron Microsc (Tokyo) 52:197-206. 2003
    ....
  55. ncbi Ultrastructural analysis of [3H]thymidine-labeled cells in the rat utricular macula
    Elizabeth C Oesterle
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 463:177-95. 2003
    ..These findings suggest that new hair cells can be generated in situ by means of a mitotic mechanism in the vestibular sensory epithelium of adult mammals...
  56. ncbi [Testing of the macula induced vestibuloocular reflex--possibilities and problems in the clinical routine]
    P Düwel
    Klinik fur Hals, Nasen und Ohrenheilkunde und Plastische Kopf und Halschirurgie des Universitätsklinikums Aachen
    Laryngorhinootologie 82:312-7. 2003
    ..On the other hand, there are just a few distinct test setups for this purpose. In clinical routine, this kind of test system has to be efficient and effective to diagnostic and therapeutic findings...
  57. ncbi Three-dimensional analysis of morphological aspects of the human utricular macula
    Hideaki Naganuma
    Department of Otorhinolaryngology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Ann Otol Rhinol Laryngol 112:419-24. 2003
    ..We determined that the 3-dimensional shape of the utricular macula was not a plane, but was a curved surface like that of an ellipsoid. We believe this shape is necessary for the utricular macula to detect wide-range linear acceleration...
  58. ncbi Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants
    Diana Berggren
    Department of Otolaryngology, Albert Einstein College of Medicine, New York, NY, USA
    Hear Res 180:114-25. 2003
    ....
  59. ncbi Gentamicin tympanoclysis: effects on the labyrinthine sensory cells
    Daniel J Pender
    Department of Otolaryngology, Columbia Presbyterian Medical Center, New York, NY, USA
    Laryngoscope 113:343-8. 2003
    ..The objective of the study was to determine whether a selective vestibular hair cell toxicity with sparing of the cochlear hair cells could be achieved by infusing different concentrations of gentamicin into the middle ears of adult cats...
  60. ncbi Afferent innervation patterns of the saccule in pigeons
    M Zakir
    Research Department, Central Institute for the Deaf, Washington University, St Louis, Missouri 63110, USA
    J Neurophysiol 89:534-50. 2003
    ....
  61. ncbi Microtubule-associated proteins in adult human sensory organs
    M Anniko
    Department of Otorhinolaryngology, Uppsala University Hospital, Akademiska sjukhuset, Sweden
    ORL J Otorhinolaryngol Relat Spec 57:78-81. 1995
    ..In contrast to such a pattern, both MAP-1 and MAP-2 were identified in the human vestibular organs, thus identifying a subpopulation of centrally located nerve calyces and possibly also the apical portion of vestibular hair cells...

Research Grants2

  1. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
    ..or with alterations in neuronal number or size? 6) What are the morphometric correlates to abnormalities on traditional vestibular testing: caloric paresis, and decreased gain and time constant on step rotational testing? ..
  2. Adenylyl Cyclase Signaling in Ear Sensory Eipthelia
    MARIAN DRESCHER; Fiscal Year: 2009
    ..The elucidation of these AC-mediated signal transduction pathways in inner ear sensory epithelia may allow eventual pharmacological amelioration of tinnitus, sensorinetiral deafness and vertigo. ..