vestibule

Summary

Summary: A small, oval, bony chamber of the labyrinth. The vestibule contains the utricle and saccule, organs which are part of the balancing apparatus of the ear.

Top Publications

  1. pmc Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule
    Atsunori Oshima
    Department of Biophysics, Faculty of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 104:10034-9. 2007
  2. pmc Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule
    Ging Kuo Wang
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    J Physiol 548:667-75. 2003
  3. ncbi Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore
    Keiko Kashiwagi
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Mol Pharmacol 61:533-45. 2002
  4. ncbi Efferent neurotransmitters in the human cochlea and vestibule
    A Schrott-Fischer
    Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria
    Acta Otolaryngol 127:13-9. 2007
  5. ncbi Electrostatics of the intracellular vestibule of K+ channels
    Vishwanath Jogini
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Mol Biol 354:272-88. 2005
  6. ncbi Experimental study on heat transmission to the vestibule during CO2 laser use in revision stapes surgery
    M Szymanski
    Department of Otolaryngology, Head and Neck Surgery, Medical University of Lublin, Poland
    J Laryngol Otol 121:5-8. 2007
  7. ncbi Neglect-like behavior in healthy subjects: dissociation of space exploration and goal-directed pointing after vestibular stimulation
    Hans Otto Karnath
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Exp Brain Res 153:231-8. 2003
  8. ncbi Functional and anatomical correlates of impaired velocity storage
    Gary P Jacobson
    Division of Audiology, Henry Ford Hospital, Detroit, MI, USA
    J Am Acad Audiol 15:324-33. 2004
  9. ncbi Latency of adaptive vergence eye movements induced by vergence-vestibular interaction training in monkeys
    Teppei Akao
    Department of Physiology, Hokkaido University School of Medicine, West 7, North 15, 060 8638, Sapporo, Japan
    Exp Brain Res 158:129-32. 2004
  10. ncbi Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid
    Hiroaki Shimogori
    Department of Otolaryngology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Pharmacol 554:223-8. 2007

Detail Information

Publications242 found, 100 shown here

  1. pmc Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule
    Atsunori Oshima
    Department of Biophysics, Faculty of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 104:10034-9. 2007
    ..This density contacts the innermost helices of the surrounding connexin subunits at the bottom of the vestibule. The density map suggests that physical blocking may play an important role that underlies gap junction channel ..
  2. pmc Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule
    Ging Kuo Wang
    Department of Anesthesia, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    J Physiol 548:667-75. 2003
    ..that (a) the VTD receptor and the LA receptor overlap extensively, (b) receptor-bound VTD lies in the inner vestibule, and (c) VTD blocks this mutant channel as a bona fide Na+ channel blocker...
  3. ncbi Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore
    Keiko Kashiwagi
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Mol Pharmacol 61:533-45. 2002
    ....
  4. ncbi Efferent neurotransmitters in the human cochlea and vestibule
    A Schrott-Fischer
    Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria
    Acta Otolaryngol 127:13-9. 2007
    ..Rodents and primates show significant differences in characteristics of efferent innervation as well as the distribution of neuroactive substances...
  5. ncbi Electrostatics of the intracellular vestibule of K+ channels
    Vishwanath Jogini
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Mol Biol 354:272-88. 2005
    ....
  6. ncbi Experimental study on heat transmission to the vestibule during CO2 laser use in revision stapes surgery
    M Szymanski
    Department of Otolaryngology, Head and Neck Surgery, Medical University of Lublin, Poland
    J Laryngol Otol 121:5-8. 2007
    We studied the transmission of heat to the vestibule during revision stapes surgery with a piston in situ, using a CO2 laser, in an in vitro model...
  7. ncbi Neglect-like behavior in healthy subjects: dissociation of space exploration and goal-directed pointing after vestibular stimulation
    Hans Otto Karnath
    Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Exp Brain Res 153:231-8. 2003
    ..The present observations strengthen substantially the assumption of different modes of space representation for action and spatial cognition in humans...
  8. ncbi Functional and anatomical correlates of impaired velocity storage
    Gary P Jacobson
    Division of Audiology, Henry Ford Hospital, Detroit, MI, USA
    J Am Acad Audiol 15:324-33. 2004
    ..Results showed that Group 2 patients had greater impairments in postural stability and gait than Group 1 patients. Additionally, 80% of patients in Group 2 and none in Group 1 showed pontine hyperintense lesions on MRI...
  9. ncbi Latency of adaptive vergence eye movements induced by vergence-vestibular interaction training in monkeys
    Teppei Akao
    Department of Physiology, Hokkaido University School of Medicine, West 7, North 15, 060 8638, Sapporo, Japan
    Exp Brain Res 158:129-32. 2004
    ..These results indicate that vestibular information can be used effectively to initiate vergence eye movements following vergence-vestibular training...
  10. ncbi Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid
    Hiroaki Shimogori
    Department of Otolaryngology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Pharmacol 554:223-8. 2007
    ..These results indicate that topical application of edaravone within 12 h after damage protects the vestibular periphery from free radical-induced toxicity in response to intracochlear infusion of AMPA...
  11. ncbi The effectiveness of wedge shoes in patients with insufficient vestibular compensation
    Munetaka Ushio
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Auris Nasus Larynx 34:155-8. 2007
    ..This study evaluated the effectiveness of wedge shoes specially manufactured with a 4mm inclination on the affected side to patients with chronic vestibular insufficiency...
  12. ncbi The contribution of otoneurological evaluation to tinnitus diagnosis
    Raquel Mezzalira
    State University of Campinas, Sao Paolo, Brazil
    Int Tinnitus J 10:65-72. 2004
    ..The otoneurological evaluation was conclusive in the diagnosis in 48 cases (75%) in group 1 and in 94 cases (72%) in group 2. The present study showed that otoneurological evaluation contributes to the etiological diagnosis of tinnitus...
  13. ncbi Vertigo in children
    Katarzyna Pawlak-Osińska
    Collegium Medicum of Nicolaus Copernicus University, Bydgoszcz, Poland
    Int Tinnitus J 12:185-9. 2006
    ..We discussed the probable reasons for vertigo, among which psychogenic origin, side effect of medications, hormonal disturbances, spondylosis, and diet errors had to be taken into consideration...
  14. ncbi Vestibulo-ocular physiology underlying vestibular hypofunction
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 710 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Phys Ther 84:373-85. 2004
    ..The purposes of this article are to review the anatomy and physiology of the vestibular system and to describe the neurophysiological mechanisms responsible for the vestibulo-ocular abnormalities in patients with vestibular hypofunction...
  15. ncbi [Vestibular compensation in patients with vestibular neuronitis]
    Anna Pajor
    Katedra Otolaryngologii UM w Lodzi, Uniwersytecki Szpital Kliniczny nr 1 im N Barlickiego
    Otolaryngol Pol 60:747-52. 2006
    ..The aim of the study was to compare the clinical and ENG outcome in different time in patients with peripheral vestibular loss diagnosed as a vestibular neuronitis in order to establish degree of compensation...
  16. ncbi Contribution of the vestibular apparatus to postural control when rising from a chair
    Takeshi Tsutsumi
    Department of Oto Rhino Laryngology, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Acta Otolaryngol 123:1054-9. 2003
    ..The aim of this study was to obtain a better understanding of the contribution made by the vestibular apparatus to postural control of the body and head when an individual rises from a chair...
  17. ncbi From head orientation to hand control: evidence of both neck and vestibular involvement in hand drawing
    Michel Guerraz
    UMR Mouvement and Perception, CNRS et Universite de la Mediterranee, 163 Avenue de Luminy, Case Postale 910, 13288 Marseille Cedex 9, France
    Exp Brain Res 150:40-9. 2003
    ..Overall the data provided evidence for a strong head-hand linkage during kinaesthetically guided drawing movements...
  18. ncbi Effect of low body temperature during unilateral labyrinthectomy on vestibular compensation in the guinea pig
    John C Ashton
    Vestibular Research Group, Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Acta Otolaryngol 123:448-52. 2003
    ..In this study we investigated changes in oculomotor and postural vestibular symptoms resulting from low body temperature during UVD...
  19. ncbi Model experiment of benign paroxysmal positional vertigo mechanism using the whole membranous labyrinth
    Koji Otsuka
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 123:515-8. 2003
    Whole membranous labyrinths of bullfrogs were used in order to replicate the human vestibule. The posterior semicircular canals (PSCs) were exposed, leaving the remaining membranous labyrinth encapsulated in the otic capsule...
  20. ncbi Superior semicircular canal dehiscence simulating otosclerosis
    G Michael Halmagyi
    Neurology Department, Royal Prince Alfred Hospital, Sydney, and the Otolaryngology Department, St Vincent s Hospital, Sydney, Australia
    J Laryngol Otol 117:553-7. 2003
    ....
  21. ncbi Sensorimotor aspects of high-speed artificial gravity: II. The effect of head position on illusory self motion
    F W Mast
    Man Vehicle Laboratory, Massachusetts Institute of Technology, MA, USA
    J Vestib Res 12:283-9. 2002
    ..The results are discussed with respect to artificial gravity in space and the possible role of pre-adaptation to cross-coupled angular accelerations on earth...
  22. ncbi Background on methods of stimulation in galvanic-induced body sway in young healthy adults
    Susan G T Balter
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Acta Otolaryngol 124:262-71. 2004
    ..The test-retest variability was determined in detail in 12 additional subjects. Prestimulation reduced habituation, but improved the sensitivity of the method; some test-retest variability persisted (< 20%)...
  23. ncbi The steady-state postural response to continuous sinusoidal galvanic vestibular stimulation
    L D Latt
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Gait Posture 18:64-72. 2003
    ..1 Hz and nearly equal at 0.45 Hz in comparison with the single-frequency responses. This study suggests that the postural sway response is nonlinear due to saturation and violation of the principle of superposition...
  24. ncbi Adaptive changes in the angular VOR: duration of gain changes and lack of effect of nodulo-uvulectomy
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1004:78-93. 2003
    ..Vertical gravity-dependent gain changes were not significantly different before and after surgery, indicating that the nodulus and uvula do not have a critical role in producing them...
  25. ncbi Bilateral vestibular loss in cats leads to active destabilization of balance during pitch and roll rotations of the support surface
    Jane M Macpherson
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon, USA
    J Neurophysiol 97:4357-67. 2007
    ..This is consistent with current models of sensory integration for computation of body posture and orientation...
  26. ncbi Human 3-D aVOR with and without otolith stimulation
    Christopher J Bockisch
    Department of Neurology, University Hospital Zurich, Frauenklinikstr 26, 8091 Zurich, Switzerland
    Exp Brain Res 161:358-67. 2005
    ..This could be because, in humans, typical yaw head movements will stimulate the otoliths to a much lesser extent then typical pitch and roll head movements...
  27. pmc Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Exp Brain Res 176:575-87. 2007
    ..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
  28. ncbi Streptomycin action to the mammalian inner ear vestibular organs: comparison between pigmented guinea pigs and rats
    Graciela Meza
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico D F, Mexico
    Comp Biochem Physiol C Toxicol Pharmacol 146:203-6. 2007
    ..We hypothesize differential drug metabolism and distribution and conclude that results in laboratory animals may not always be applicable in the human situation...
  29. ncbi Visual vestibular mismatch in work-related vestibular injury
    N S Longridge
    Neuro Otology Unit, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Otol Neurotol 26:691-4. 2005
    ..To define and investigate the symptom set known as visual-vestibular mismatch and analyze its nature and occurrence in two groups of patients referred for dizziness...
  30. ncbi Do you know where your arm is if you think your head has moved?
    Joanna J Knox
    Division of Physiotherapy, School of Health and Rehabilitation Sciences, The University of Queensland, 4072 Brisbane, QLD, Australia
    Exp Brain Res 173:94-101. 2006
    ..These results support the hypothesis that the perceived position of proximal body segments is used in the planning and performance of accurate upper limb movements...
  31. ncbi Bilateral vestibular loss leads to active destabilization of balance during voluntary head turns in the standing cat
    Paul J Stapley
    Balance and Voluntary Movement Laboratory, Department of Kinesiology and Physical Education, McGill University, 475 Pine Ave West, Montreal, Quebec H2W 1S4, Canada
    J Neurophysiol 95:3783-97. 2006
    ..We postulate that the postural imbalance arises from the misperception that the trunk was rolling contralaterally, based on signals from neck proprioceptors in the absence of vestibular inputs...
  32. ncbi The role of vestibular rehabilitation in the treatment of Meniere's disease
    Kim R Gottshall
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, CA 92134, USA
    Otolaryngol Head Neck Surg 133:326-8. 2005
    ..To study the role of vestibular rehabilitation is treating patients with Meniere's disease...
  33. ncbi Stimulus-dependent changes in the vestibular contribution to human postural control
    Massimo Cenciarini
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Neurophysiol 95:2733-50. 2006
    ..GVS-evoked sway increased with increasing SS amplitude, and Wp measures derived from responses to GVS and from responses to SS rotations were highly correlated...
  34. ncbi Neuro-otological features of benign paroxysmal vertigo and benign paroxysmal positioning vertigo in children: a follow-up study
    Vincenzo Marcelli
    Audiology Unit, Department of Neuroscience and Behavioural Science, University of Naples Federico II, Italy
    Brain Dev 28:80-4. 2006
    ..Causes of benign episodic vertigo in paediatric age include benign paroxysmal vertigo of childhood (BPV) and benign paroxysmal positional vertigo (BPPV)...
  35. ncbi VEMPs and dynamic posturography after intratympanic gentamycin in Menière's disease
    Pasqualina M Picciotti
    Department of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy
    J Vestib Res 15:161-8. 2005
    ..In addition, our data indicate that DP might provide important information on compensation phenomena and show that intratympanic gentamycin can improve postural control in MD patients...
  36. ncbi Function tests of the otolith or statolith system
    Herman Kingma
    Division of Balance Disorders, Department of ENT, University Hospital Maastricht, Maastricht Research Institute Brain and Behaviour, Maastricht University, The Netherlands
    Curr Opin Neurol 19:21-5. 2006
    ..This review aims to provide an overview of recent advances in tests to evaluate otolith function over the last 2 years...
  37. ncbi Development of sensory motor reflexes in 2 G exposed rats
    Rene Wubbels
    Vestibular Department ENT, Academic Medical Center, Amsterdam, NL
    J Gravit Physiol 11:P21-2. 2004
    ..HG induced a retarded development of vestibular dependent reflexes. Other types of motor behavior were not delayed...
  38. ncbi [Built-in emergency brake in the balance system. Animal experiment research shows that a hierarchy of mechanisms compensate after acute peripheral vestibular decline]
    Anna K Magnusson
    Abteilung Neurobiologie, Ludwig Maximilians Universitat, Munchen
    Lakartidningen 102:1524-6, 1529. 2005
    ..In the long run, such knowledge might influence the management and treatment of patients with balance disorders...
  39. ncbi Sensorimotor postural rearrangement after unilateral vestibular deafferentation in patients with acoustic neuroma
    Cécile Parietti-Winkler
    Balance Control and Motor Performance, UFR STAPS, Henri Poincare University, Nancy 1, Villers les Nancy, France
    Neurosci Res 55:171-81. 2006
    ..The time-course implementation of central adaptive mechanisms, characterized by substitution by other sensory afferences and new behavioural strategies, leads to an improvement of balance performance...
  40. ncbi A neural network approach to motor-sensory relations during postural disturbance
    Ge Wu
    Department of Physical Therapy, University of Vermont, Burlington, VT 05405, USA
    Brain Res Bull 69:365-74. 2006
    ..These findings are supported by previous studies and have demonstrated the potential of the Q-value concept in the ANN model in studying the motor-sensory relationship in human postural control...
  41. ncbi [Head shaking test (HSN) using to diagnose vestibule damage]
    Alina Morawiec-Bajda
    Oddział Kliniczny Chirurgii Nowotworów Głowy i Szyi Uniwersytetu Medycznego w Lodzi
    Otolaryngol Pol 60:407-13. 2006
    ..Estimation of HSN test value to show asymmetrical function of vestibular system 3. Establish possibility of HSN test to localization of damage vestibular system 4. Verification this test to use it as screening test..
  42. ncbi Enhanced smooth pursuit eye movements in patients with bilateral vestibular deficits
    Christopher J Bockisch
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Neuroreport 15:2617-20. 2004
    ..We suggest that the challenge of living with a deficient vestibular system caused an enhancement in the pursuit system, which contributes to the patient's overall compensation...
  43. ncbi Subjective visual horizontal in the upright posture and asymmetry in roll-tilt perception: independent measures of vestibular function
    Arne Tribukait
    Department of Audiology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Vestib Res 16:35-43. 2006
    ....
  44. ncbi Vestibular assessment in a patient with confirmed lateral medullary syndrome
    Katrina F L Butler
    Department of Audiology, Addenbrooke s NHS Trust, Cambridge, UK
    J Laryngol Otol 120:135-7. 2006
    ..This patient showed a unilateral weakness on caloric testing which has not been reported previously in a patient with lateral medullary syndrome. The case for the possibility of a 'central' canal paresis on caloric testing is presented...
  45. ncbi Perception of angular displacement without landmarks: evidence for Bayesian fusion of vestibular, optokinetic, podokinesthetic, and cognitive information
    Reinhart Jurgens
    Sektion Neurophysiologie, Universitat Ulm, Albert Einstein Allee 47, 89081 Ulm, Germany
    Exp Brain Res 174:528-43. 2006
    ..Our experimental data agree with the relation between (1) the variance of displacement estimates and (2) their modulation by velocity predicted by this scheme...
  46. ncbi Vestibular, proprioceptive, and haptic contributions to spatial orientation
    James R Lackner
    Ashton Graybiel Spatial Orientation Laboratory, Brandeis University, Waltham, MA 02454, USA
    Annu Rev Psychol 56:115-47. 2005
    ..Path integration, place cells, and head direction cells are described along with implications for using immersive virtual environments for training geographic spatial knowledge of real environments...
  47. ncbi Efficacy of tilt-suppression in postrotatory nystagmus in cats
    Hiroaki Fushiki
    Department of Otolaryngology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Brain Res 1108:127-32. 2006
    ....
  48. ncbi Effects of vestibulo-ocular reflex exercises on vestibular compensation after vestibular schwannoma surgery
    Joanne C Enticott
    Departments of Otolaryngology, The University of Melbourne, East Melbourne, Australia
    Otol Neurotol 26:265-9. 2005
    ..To assess vestibular function in a large group of vestibular schwannoma patients so that we could determine whether simple vestibular exercises speed vestibular dysfunction recovery after tumor removal surgery...
  49. ncbi Postural responses triggered by multidirectional leg lifts and surface tilts
    Lucinda K Hughey
    School of Physical and Occupational Therapy, McGill University, 3654 Prom Sir William Osler, Montreal, Quebec, Canada, H3G 1Y5
    Exp Brain Res 165:152-66. 2005
    ..In conclusion, regardless of the type (voluntary versus involuntary) or direction of perturbation, the strategy employed by the central nervous system to control the body COM displacement concerns mainly trunk stabilization...
  50. ncbi CGRP expression in the vestibular periphery after transient blockage of bilateral vestibular input
    Hirotaka Hara
    Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    ORL J Otorhinolaryngol Relat Spec 67:259-65. 2005
    ..An animal model of reversible bilateral vestibular disorders was established and used for investigating the plasticity of the vestibular nervous system...
  51. ncbi Dizziness: relating the severity of vertigo to the degree of handicap by measuring vestibular impairment
    Nicolas Perez
    Department of Otorhinolaryngology, University Hospital and Medical School, University of Navarra, Pamplona, Spain
    Otolaryngol Head Neck Surg 128:372-81. 2003
    ..We sought to correlate the severity of vertigo and handicap in patients with vestibular pathology according to measures of impairment...
  52. ncbi [Bilateral vestibular loss. Diagnosis and follow-up]
    K A Frese
    Klinik fur Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Kiel
    HNO 51:221-5. 2003
    ..Atypical symptom in patients with bilateral vestibular loss is head movement-induced oscillopsia. The paucity of precise complaints in many patients is surprising. Therefore, bilateral loss of vestibular function is often undiagnosed...
  53. ncbi Vestibulospinal control of posture
    Fay B Horak
    Neurological Sciences Institute of Oregon Health Sciences University, Beaverton 97212, USA
    Adv Exp Med Biol 508:139-45. 2002
    ..Furthermore, visual information or somatosensory information from light touch of a finger on a stable reference can significantly substitute for loss of vestibular function...
  54. ncbi [Bilateral vestibular areflexia: quantification is required]
    E Ulmer
    Service ORL et Chirurgie Cervico Faciale, CHU Nord, 13915 Marseille Cedex 20, France
    Ann Otolaryngol Chir Cervicofac 119:216-26. 2002
    ..The apparent vestibular loss is actually related to stimulation frequency. This phenomenon could be explained by considering the physiology of phasic and tonic cells...
  55. ncbi Consequences and assessment of human vestibular failure: implications for postural control
    James G Colebatch
    Department of Neurology and Clinical School, Prince of Wales Hospital, NSW, Sydney, Australia
    Adv Exp Med Biol 508:105-10. 2002
    ..Recent definition of a short latency vestibulocollic reflex, activated by sound and appearing to arise from the saccule, shows promise as a new method of non-invasive assessment of otolith function...
  56. ncbi Early compensation of vestibulo-oculomotor symptoms after unilateral vestibular loss in rats is related to GABA(B) receptor function
    A K Magnusson
    Department of Biomedicine and Surgery, Division of Cell Biology, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    Neuroscience 111:625-34. 2002
    ..A possible role for GABA(B) receptors in the reciprocal inhibitory commissural pathways in the vestibular nuclei is suggested...
  57. ncbi [The influence of metabolic disturbances present in diabetes mellitus type I on vestibulo-spinal reflexes in children and young adults]
    Wojciech Gawron
    Katedra i Klinika Otolaryngologii AM we Wrocławiu
    Otolaryngol Pol 56:451-7. 2002
    ..Balance organ disturbances in diabetes mellitus type 1 in children and young adults despite their presence have subclinical course. Perhaps one should consider monitoring of those disturbances in the course of the disease...
  58. ncbi Deficits and recovery of head and trunk orientation and stabilization after unilateral vestibular loss
    L Borel
    Laboratoire de Neurobiologie Integrative et Adaptative, Université de Provence CNRS Centre de St Jérôme, Marseille, France
    Brain 125:880-94. 2002
    ..They also support the notion that vestibular compensation relies on visual cues whose substitution role gradually decreases after UVN...
  59. ncbi Vestibular contributions across the execution of a voluntary forward step
    Leah R Bent
    School of Human Kinetics, The University of British Columbia, Vancouver, B C, Canada
    Exp Brain Res 143:100-5. 2002
    ..Also, the level of up-regulation may be different across step execution...
  60. ncbi Non-linear interaction of angular and translational vestibulo-ocular reflex during eccentric rotation in the monkey
    L Fuhry
    Institute of Physiology, Academy of Sciences of the Czech Republic, Praha
    Exp Brain Res 143:303-17. 2002
    ..We conclude that angular and translational VOR have different latencies during transient accelerations and interact differently during agonistic (nose-out) and antagonistic stimulation (nose-in)...
  61. ncbi Comparison between habituation of the cat vestibulo-ocular reflex by velocity steps and sinusoidal vestibular stimulation in the dark
    Gilles Clement
    Centre de Recherche Cerveau et Cognition, UMR 5549 CNRS UPS, Toulouse, France
    Exp Brain Res 142:259-67. 2002
    ..Previous reports of vestibular habituation induced by repeated sinusoidal oscillations may be confounded by the fact that the angular velocity steps used for quantifying the effects may have been responsible for this habituation...
  62. ncbi Effectiveness of the particle repositioning maneuver in benign paroxysmal positional vertigo with and without additional vestibular pathology
    Lea Pollak
    Department of Neuro otology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, England, UK
    Otol Neurotol 23:79-83. 2002
    ....
  63. ncbi Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig
    Osamu Horiike
    Department of Otolaryngology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Yamaguchi 755 8505, Ube, Japan
    Eur J Pharmacol 464:75-8. 2003
    ..Animals injected with saline showed statistically smaller gains than those injected with edaravone. These results suggest that edaravone suppresses streptomycin-induced vestibulotoxicity...
  64. ncbi Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor
    H R Arias
    Instituto de Investigaciones Bioquimicas de Bahia Blanca, Consejo Nacional de Investigaciones Cientificas y Tecnicas, and Universidad Nacional del Sur, Blanca, Argentina
    Biochim Biophys Acta 1376:173-220. 1998
    ..to a non-annular lipid domain located approximately 7 A from the lipid-water interface and ethidium binds to the vestibule of the AChR in a site located approximately 46 A away from the membrane surface and equidistant from both ACh ..
  65. ncbi A new classification for cochleovestibular malformations
    Levent Sennaroglu
    Department of Otolaryngology Head and Neck Surgery, Hacettepe University, Ankara, Turkey
    Laryngoscope 112:2230-41. 2002
    ..The report proposes a new classification system for inner ear malformations, based on radiological features of inner ear malformations reviewed in 23 patients...
  66. ncbi Study of viridans streptococci and Staphylococcus species in cleft lip and palate patients before and after surgery
    Erry Mochamad Arief
    School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
    Cleft Palate Craniofac J 42:277-9. 2005
    ..To determine the effect of surgery on types and colony count of Streptococcus and Staphylococcus species in cleft lip and palate (CLP) patients...
  67. ncbi Clinical, experimental, and theoretical investigations of the effect of superior semicircular canal dehiscence on hearing mechanisms
    John J Rosowski
    Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:323-32. 2004
    ..input impedance, 2) shunts air-conducted sound away from the cochlea resulting in conductive hearing loss, and 3) improves bone-conduction thresholds by increasing the difference in impedance between the vestibule and the round window.
  68. ncbi Magnetic resonance imaging of the inner ear in Meniere's disease
    Ilmari Pyykko
    Department of Otolaryngology, University of Tampere, Teiskontie 35, 33520, Tampere, Finland
    Otolaryngol Clin North Am 43:1059-80. 2010
    ..The initial portions of the organ to be filled were the basal turn of the cochlea and vestibule. In animal models with endolymphatic hydrops (EH), bulging of the Reissner's membrane was observed as deficit of ..
  69. ncbi Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2
    Heike Jäger
    Department of Applied Physiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Toxicon 43:951-60. 2004
    ..of a single residue could create a new high affinity binding site for CTX and KTX we concluded that the outer vestibule around position V342, S344, and G348 of the SK2 K+ channel pore is very similar to those of voltage-gated K+ ..
  70. ncbi Preoperative evaluation of the congenital aural atresia on computed tomography; an analysis of the severity of the deformity of the middle ear and mastoid
    Mustafa Tasar
    Gulhane Medical School, Department of Radiology, Etlik Ankara, Turkey
    Eur J Radiol 62:97-105. 2007
    ..To compare the development of temporal bone in normal and atretic ears and to assess some radiological landmarks that could be important in the hearing restoration interventions in such patients...
  71. ncbi Effects of temperature, storage time and media on periodontal and pulpal healing after replantation of incisors in monkeys
    O Schwartz
    Department of Oral and Maxillofacial Surgery, University Hospital Rigshospitalet Copenhagen, Denmark
    Dent Traumatol 18:190-5. 2002
    ..e. in the buccal vestibule) at 37 degrees C for either 60 or 120 min prior to replantation...
  72. ncbi Comparison of examination methods used in the evaluation of prepubertal and pubertal female genitalia: a descriptive study
    Cathy Boyle
    CAARE Diagnostic and Treatment Center, University of California, Davis, Children s Hospital, 3300 Stockton Boulevard, Sacramento, CA 95820 1451, USA
    Child Abuse Negl 32:229-43. 2008
    ..To compare the effectiveness of three different examination methods in their ability to help the examiner detect both acute and non-acute genital injuries in prepubertal and pubertal girls suspected of having been sexually abused...
  73. ncbi The intravestibular source of the vestibular aqueduct: Its structure and pathology in Ménière's disease
    L Michaels
    University College London Ear Institute and Department of Histopathology, Royal Free and UCL Medical School, Rockefeller Building, University Street, London, UK
    Acta Otolaryngol 129:592-601. 2009
    ..This may lead to serious chemical change in the nearby endolymph and so provoke the symptoms of MD...
  74. ncbi Anatomic evaluation of the membranous labyrinth by imaging: 3D-MRI volume-rendered reconstructions
    A Migueis
    Coimbra University School of Medicine, Department of Anatomy, Rua Larga, 3004 504 Coimbra, Portugal
    Rev Laryngol Otol Rhinol (Bord) 128:37-40. 2007
    ..The authors aimed at verifying the contribution of VR in the study of labyrinthine pathology in view of all the possible anatomic correlation...
  75. ncbi Vestibular evoked myogenic potentials in humans: a review
    C Ferber-Viart
    Fédération d Explorations Audiovestibulaires, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Acta Otolaryngol 119:6-15. 1999
    The human vestibule has preserved an ancestral sound sensitivity and it has been suggested that a reflex could originate from this property, thus inducing cervical muscle microcontractions secondary to strong acoustic stimulations...
  76. ncbi Effects of general anesthesia and paralysis on upper airway changes due to head position in humans
    M Sivarajan
    Seattle Veterans Affairs Medical Center, University of Washington, Washington, USA
    Anesthesiology 85:787-93. 1996
    ..However, the independent effects of head position, general anesthesia, and muscle paralysis on upper airway structures are not known...
  77. ncbi Unpartitioned versus incompletely partitioned cochleae: radiologic differentiation
    Levent Sennaroglu
    Department of Otolaryngology Head and Neck Surgery, Hacettepe University, Sihhiye, Ankara, Turkey
    Otol Neurotol 25:520-9; discussion 529. 2004
    ..interscalar septum and entire modiolus were absent, giving the cochlea a cystic appearance; a grossly dilated vestibule accompanied this lesion...
  78. ncbi Oral mucosal blood flow following dry ice stimulation in humans
    J G Heckmann
    Department of Neurology, University of Erlangen Nuremberg, Germany
    Clin Auton Res 10:317-21. 2000
    ..change of blood flow, recordings were made for the tongue and at the mucosa of the hard palate, lip, and oral vestibule. The authors investigated 26 patients divided into groups of younger subjects (10 men, 3 women; age range 21-31 ..
  79. ncbi The morphology of the inner ear from the domestic pig (Sus scrofa)
    J M Lovell
    Faculty of Science, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    J Microsc 228:345-57. 2007
    ..of Scanning and Transmission Electron Microscopy (SEM and TEM), revealing hair cells from the cochlea and vestibule using a novel surgical and technical approach. This is the first time that the inner ear hair cells from S...
  80. ncbi The role of nasal cavity disinfection in the bacteriology of chronic sinusitis
    Ph Rombaux
    Department of Otorhinolaryngology, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Rhinology 43:125-9. 2005
    ..We investigated the potential role of nasal cavity disinfection in the bacteriology of the bulla ethmoidalis in patients suffering from chronic sinusitis...
  81. ncbi Measurements of human middle ear forward and reverse acoustics: implications for otoacoustic emissions
    Sunil Puria
    Stanford University, Mechanics and Computation Division, Palo Alto, California 94305, USA
    J Acoust Soc Am 113:2773-89. 2003
    ..microphone within 3 mm of the eardrum, (b) Vst--stapes velocity with a laser interferometer, and (c) Pv--vestibule pressure with a hydrophone...
  82. ncbi A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia
    J Tesfaigzi
    Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
    Am J Respir Cell Mol Biol 14:478-86. 1996
    ..high levels of SPRR1 transcript were detected by in situ hybridization in squamous epithelia that line the nasal vestibule and hard palate of the rat...
  83. ncbi Isolation and identification of yeast flora from genital tract in healthy female camels (Camelus dromedarius)
    Hojjatollah Shokri
    Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    Vet Microbiol 144:183-6. 2010
    ..The samples were taken from different parts of genital tract including vestibule, vagina, cervix, uterine body, and uterine horns of 50 camels using sterilized cotton swabs...
  84. ncbi Biofilms in the edentulous oral cavity
    Amit Sachdeo
    Department of Prosthodontics, Tufts University School of Dental Medicine, Boston, MA 02111, USA
    J Prosthodont 17:348-56. 2008
    ....
  85. ncbi [Results of treatment papilloma of nasal cavity and paranasal sinuses]
    Marek Łukomski
    I Katedra Otolaryngologii UM w Łodzi
    Otolaryngol Pol 62:574-7. 2008
    ..Especially inverted papilloma tumor has a significant recurrence and malignancy potential rate. The aim of the study was the analysis of clinical and treatment outcomes of patients with papilloma of the nose and paranasal sinuses...
  86. ncbi Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages
    J S Kimbell
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Mutat Res 380:143-54. 1997
    Squamous epithelium lines the nasal vestibule of the rat, rhesus monkey, and human. Respiratory, transitional, and olfactory epithelia line most areas posterior to the nasal vestibule...
  87. ncbi Importance of using guarded techniques for the preparation of endometrial cytology smears in mares
    Javier Aguilar
    University of Edinburgh, Royal Dick School of Veterinary Studies, Easter Bush, Midlothian EH25 9RG, Scotland, United Kingdom
    Theriogenology 66:423-30. 2006
    ..samples were collected from a further seven non-pregnant mares at different reproductive stages, and tissues (vestibule, vagina and cervix) from four reproductively normal mares were examined histologically after slaughter to detect ..
  88. ncbi Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects
    R E Swiderski
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Dev Dyn 216:16-27. 1999
    ..strong signal was observed in the dorsal portion of the septum primum, in what appeared to be the spinal vestibule. At day 13 p.c...
  89. ncbi [Healing efficacy of repairing mucosa defect with heterogeneity acellular dermal matrix]
    Yan Sun
    Department of Otorhinolaryngology Cervical Surgery, Yantai Yuhuangding Hospital, Yantai Shandong, 264000, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:53-5. 2008
    ..To introduce the clinical application of heterogeneity (cattle) acellular dermal matrix (ADM) in the repair of mucosa defect otolaryngology...
  90. doi [Vestibulo-cochlear disturbances in the course of vaso-neural conflict of vestibule-cochlear nerve--diagnostic and therapeutic problems]
    Krystyna Orendorz-Fraczkowska
    Katedra i Klinika Otolaryngologii AM we Wrocławiu
    Otolaryngol Pol 61:473-8. 2007
    ..The diagnostics in such cases is especially difficult and often requires interdisciplinary cooperation. Despite of that many cases remain unexplained...
  91. ncbi Development of calretinin immunoreactivity in the mouse inner ear
    C J Dechesne
    Laboratoire de Neurophysiologie Sensorielle, Unité INSERM 254, Montpellier, France
    J Comp Neurol 346:517-29. 1994
    ..In the adult mouse vestibule, calretinin immunoreactivity was present in the same structures as described for the rat and guinea pig: the ..
  92. pmc Defining the normal bacterial flora of the oral cavity
    Jørn A Aas
    Institute of Oral Biology, University of Oslo, Postbox 1052 Blindern, 0316 Oslo, Norway
    J Clin Microbiol 43:5721-32. 2005
    ..hard palate, soft palate, supragingival plaque of tooth surfaces, subgingival plaque, maxillary anterior vestibule, and tonsils. 16S rRNA genes from sample DNA were amplified, cloned, and transformed into Escherichia coli...
  93. ncbi Differential impact of hypergravity on maturating innervation in vestibular epithelia during rat development
    Sophie Gaboyard
    INSERM U432, Universite Montpellier II, Place E Bataillon, 34095 Montpellier, Cedex 05, France
    Brain Res Dev Brain Res 143:15-23. 2003
    ..we used a ground-based centrifuge to increase the gravitational vector, in order to hyperstimulate the vestibule. In this study, 3 days after mating, pregnant females were submitted to hypergravity, 2 g (HG)...
  94. ncbi Expression of an Otx gene in the adult rudiment and the developing central nervous system in the vestibula larva of the sea urchin Holopneustes purpurescens
    Valerie B Morris
    Biological Sciences A 12, University of Sydney, NSW, Australia
    Int J Dev Biol 48:17-22. 2004
    ..A short time later, expression is absent from the ectoderm on the oral side of the gastrula where the vestibule will form...
  95. ncbi Discovery of new Ohbayashinema spp. (Nematoda: Heligmosomoidea) in Ochotona princeps and Ochotona cansus (Lagomorpha: Ochotonidae) from western North America and Central Asia, with considerations of historical biogeography
    M C Durette-Desset
    Département de Systématique et Evolution, Museum national d histoire naturelle, UMR 7138 associee au CNRS, CP 52, 61 rue Buffon, 75231 Paris Cedex 05, France
    J Parasitol 96:569-79. 2010
    ..It is mainly differentiated by an uncoiled anterior extremity and by near equal dimensions of the vestibule and the uterus. The third species, Ohbayashinema patriciae n. sp...
  96. ncbi Fluoride tablet programs in healthy elderly subjects: distribution of fluoride in saliva and plaque with tablets in different sites
    Pål Arneberg
    Department of Cariology, Dental Faculty, University of Oslo, Norway
    Acta Odontol Scand 63:65-72. 2005
    ..Flavored and unflavored tablets dissolved passively either under the tongue or in the vestibule close to the root caries risk areas...
  97. ncbi Inner ear anomalies and conductive hearing loss in children with Apert syndrome: an overlooked otologic aspect
    Guangwei Zhou
    Department of Otolaryngology and Communication Enhancement, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Otol Neurotol 30:184-9. 2009
    ..To identify the occurrence of inner ear structural anomalies and conductive hearing loss (CHL) in children with Apert syndrome...
  98. ncbi [Skull vibration induced nystagmus test]
    G Dumas
    Service ORL, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
    Ann Otolaryngol Chir Cervicofac 124:173-83. 2007
    To establish during a consensus meeting the fundamental basis, the validity criteria, the main indications and results of the skull vibration induced nystagmus test (SVINT) which explores the vestibule high frequencies.
  99. pmc An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels
    Andreas Nolting
    Laboratory of Molecular Pharmacology, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 282:3478-86. 2007
    ..Three amino acids located in the outer vestibule of the pore are of particular importance for the different apamin sensitivities of SK channels...
  100. pmc Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis
    Ana Carolina Monteiro
    Carlos Chagas Filho Institute of Biophysics, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 183:3700-11. 2009
    ..Using a model of buccal infection based on P. gingivalis inoculation in the anterior mandibular vestibule, we studied whether kinins released by gingipain may link mucosal inflammation to T cell-dependent immunity ..
  101. ncbi Viral antigen distribution in the respiratory tract of cattle persistently infected with bovine viral diarrhea virus subtype 2a
    A W Confer
    Department of Veterinary Pathobiology and the Oklahoma Animal Disease Diagnostic Laboratory, 211 McElroy Hall, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Pathol 42:192-9. 2005
    Tissues were obtained at necropsy from the nasal vestibule, turbinates, nasopharynx, trachea, tracheobronchial bifurcation, and lung from each of 10 clinically healthy calves persistently infected (PI) with bovine viral diarrhea virus (..

Research Grants62

  1. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid residues as suggested by molecular modeling;3- causes the ..
  2. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid residues as suggested by molecular modeling;3- causes the ..
  3. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..5. Generate apparatus for heart rate and blood pressure measurements in the rat to determine the impact of the vestibule-sympathetic reflex during changes in head position relative to gravity. 6...
  4. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..We propose to expand to presumed non-competitive sites on this molecule, in particular the vestibule leading into the channel constriction and the non-a subunit interfaces that do not bind agonist...
  5. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..An unexpected second substrate binding (S2) site located in the extracellular vestibule was identified during the previous project period;binding and flux experiments showed that the two binding sites ..
  6. MECHANISM OF INOSITOL TRISPHOSPHATE ACTION
    Suresh K Joseph; Fiscal Year: 2010
    ..Site-directed mutations will be made to identify residues that are part of the vestibule of the pore or the pore itself...
  7. Genome-wide association to Staphylococcus carriage
    Craig L Hanis; Fiscal Year: 2013
    ..Staphylococcus aureus is an opportunistic pathogen that colonizes the skin (primarily the anterior nasal vestibule) of as many as 1 out 4 individuals without causing clinical disease symptoms...
  8. Biogenic Amine Transporters: Mechanisms of Ligand Interaction
    MAARTEN E REITH; Fiscal Year: 2013
    ..Novel evidence indicates the presence in LeuT of a secondary substrate site (S2) in the outer vestibule, playing a fundamental role in substrate uptake...
  9. Catalytic Antibodies To Staphylococcus Aureus: Identification and Characterizatio
    Eric L Brown; Fiscal Year: 2010
    ..S. aureus is an opportunistic pathogen that colonizes the skin (primarily the anterior nasal vestibule) of approximately 20-30% of the population without causing clinical symptoms...
  10. Identifying therapeutic targets for vulvodynia
    Peter G Smith; Fiscal Year: 2013
    ..pain syndrome is characterized by increased numbers of nociceptor axons usually localized to the posterior vestibule. Clinical evidence suggests that reproductive hormones influence the development and severity of vulvar ..
  11. Function of LIM-domain Transcriptional Regulators in Inner Ear Development
    Lin Gan; Fiscal Year: 2012
    ..To determine the requirement for LMO4 in the sensory and neuronal development in the cochlea and vestibule by targeted disruption of LMO4;2)...
  12. A Controlled Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
    DAVID CHARLES FOSTER; Fiscal Year: 2013
    ..crossover study will enroll 120 women between 18-50 years of age who report tenderness localized to the vulvar vestibule, pain with tampon insertion, and, when sexually active, insertional dyspareunia...
  13. Localized Vulvodynia Pathogenesis: Fibroblast, Yeast, and Melanocortin
    Richard P Phipps; Fiscal Year: 2013
    ..Fibroblasts also exhibit considerable regional specialization. We discovered that fibroblasts from the vulvar vestibule produce markedly elevated levels of pro-inflammatory, pro-pain mediators following activation with yeast cell ..
  14. Investigating the role of Substrate Binding in LeuT Transport With RosettaEPR
    STEPHANIE JUDITH HIRST DELUCA; Fiscal Year: 2013
    ..and hydration of the substrate permeation pathway, while subsequent binding of leucine causes the extracellular vestibule to close and become rigid...
  15. Extending Chemical Synthesis to Ion Channel Proteins
    Francis Valiyaveetil; Fiscal Year: 2013
    ..Aim 3) We will investigate the binding of divalent ions to the outer vestibule of the NaK channel using chemical synthesis...
  16. An Integrated System for Single Molecule Electronic Sequencing by Synthesis
    JAMES JOHN RUSSO; Fiscal Year: 2013
    ..attached to the nanopore by a short linker so the polymeric tag will have sufficient time to enter the vestibule and constriction of the nanopore prior to its release ensuring that its current blockade signal is recorded by ..
  17. ORAL MUCOSA MICROBIOTA IN HEALTH, CANCER & MUCOSITIS
    Donna Mager; Fiscal Year: 2004
    ..will be taken from the dorsum, lateral and ventral surfaces of the tongue, floor of mouth, cheek, hard palate, vestibule/lip, attached gingiva and saliva as well as supra and subgingival plaque of the mesial aspect of each tooth in ..
  18. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
    ..fluorescence and confocal microscopy, computerized measurements with a new non-invasive animal technique of vestibule oculography for VOR function testing and electrophysiological single fiber recording methods...
  19. MOLECULAR PHARMACOLOGY OF VOLTAGE SENSITIVE NA CHANNELS
    Edward Moczydlowski; Fiscal Year: 2001
    ..2. Define the electrostatic contribution of charged residues in the outer vestibule to ionic selectivity, conductance, and external block by inorganic cations. 3...
  20. STRUCTURE/FUNCTION STUDY OF A VOLTAGE GATED K CHANNEL
    Rolf Joho; Fiscal Year: 2000
    ..The investigator proposes to use cysteine-substituted K+ channel mutants to measure distances in the vestibule and the ion conduction pathway of the channel applying homo- and heterobifunctional crosslinkers with spacers of ..
  21. VOLITIONAL, BOLUS, AND AGE EFFECTS ON HUMAN SWALLOWING
    Peter Kahrilas; Fiscal Year: 2000
    ..swallow as a tightly integrated group of functional elements (closure of the nasopharynx, UES Opening, laryngeal vestibule closure, tongue loading (ramping), tongue pulsion, and pharyngeal clearance), each subject to specific ..
  22. EVALUATION OF THE NA+ CHANNEL OUTER VESTIBULE
    SAMUEL DUDLEY; Fiscal Year: 2004
    ..The aim of the proposed project is to test, refine, and expand a molecular model of the outer vestibule and selectivity filter of the Na+ channel as part of larger effort to understand the structural biology of this ..
  23. Activation Gating in Human Heart Na+ Channels
    Sho Ya Wang; Fiscal Year: 2004
    ..as local anesthetics, antiarrhythmics, and anticonvulsants to their receptor(s) within the Na+ channel inner vestibule. Detailed mapping of the cytoplasmic S6 regions along with their linkage with the Na+ channel activation gating ..
  24. Vestibular and Neck Contribution to Oculomotor Processing in the Frontal Cortex
    LEWIS CHEN; Fiscal Year: 2009
    ..Some recent studies have shown that non-oculomotor variables, such as vestibule and/or neck proprioception, can alter the oculomotor coordinates...
  25. DEVELOPMENT OF VESTIBULAR NUCLEI NEURONS
    KENNA PEUSNER; Fiscal Year: 2005
    ..The principal cells of this nucleus are second-order vestibular neurons participating in the three-neuron vestibule-ocular and vestibulocollic reflexes, which are involved in coordinating head and eye movements...
  26. K+ channel-neurotoxin complexes
    Yanxiang Zhao; Fiscal Year: 2005
    ..are devoted to the structural characterization of ion channels, the neurotoxins which bind at the extracellular vestibule of potassium channels with high specificity can serve as powerful investigative tools...
  27. ELECTROPHYSIOLOGICAL STUDIES OF THE KCSA K+ CHANNEL
    Lise Heginbotham; Fiscal Year: 2004
    ..Our third major aim is to examine the functional consequences of structural rearrangements of the inner vestibule during gating...
  28. VOLTAGE SENSITIVE NA CHANNELS--SURFACE ARCHITECTURE
    ROLAND KALLEN; Fiscal Year: 2002
    We propose to determine the three-dimensional architecture of the outer vestibule/pore region of the rat skeletal muscle subtype 1 (rSkM1) voltage-sensitive sodium channel...
  29. MODULATION OF K+ CHANNEL FUNCTION BY PERMEANTIONS
    Stephen Korn; Fiscal Year: 2004
    ..This mechanism, which involves a conformational change in the outer vestibule of the pore, is controlled by physiologically relevant changes in K+ concentration, and dramatically influences ..
  30. ORPHAN NUCLEAR RECEPTOR COUP-TFI IN HEARING AND BALANCE
    Fred Pereira; Fiscal Year: 2000
    ..loss-of-function mutants are deaf, having defects in development of the cochlea and sensory maculae of the vestibule. This suggests that COUP-TFI is an essential gene for the development of both hearing and balance functions in ..
  31. Comprehensive Positioning Management System
    John Epley; Fiscal Year: 2003
    ..to develop and refine a comprehensive positional management system (CPM System) for positional manifestations of vestibule disorders for widespread application at medical and research facilities...
  32. Measuring ion channel pore dynamics with fluorescence
    Stephen Korn; Fiscal Year: 2003
    ..The functionally rich outer vestibule/selectivity filter region of the potassium channel pore has been considered to have just a single conformation ..
  33. Orphan Nuclear Receptor COUP TFI in Hearing and Balance
    Fred Pereira; Fiscal Year: 2005
    ..Identify COUP-TFI downstream targets during inner ear development by subtraction library screens of cochlea and vestibule cDNA libraries...
  34. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  35. Adaptation of Spatial Orientation in Locomotion and Posture
    FAY BAHLING HORAK; Fiscal Year: 2010
    ..abstract_text> ..
  36. PERIPHERAL AND CENTRAL POSTURAL DISORDERS IN THE ELDERLY
    Fay Horak; Fiscal Year: 2003
    ..abstract_text> ..
  37. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  38. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..
  39. QUANTITATIVE MORPHOPHYSIOLOGY OF VESTIBULAR AFFERENTS
    GOLDA KEVETTER; Fiscal Year: 2004
    ..This could prove important for treatment of patients with vestibular disorders, such as those suffering with Meniere's disease or even normal aging. ..
  40. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
    ..The design of these studies will increase our understanding of how the vestibular system contributes to orthostatic blood pressure regulation in humans. ..
  41. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
  42. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
    ....
  43. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..Quantifying two types of postural and oromotor control in the same subjects will also substantially increase our understanding of the role of the basal ganglia in axial motor control. ..
  44. Chemoanatomic bases for peripheral vestibular function
    GAY HOLSTEIN; Fiscal Year: 2007
    ..The proposed research is unique, and will have direct bearing on the development of more effective therapeutic interventions, both medicinal and device-oriented, for peripheral vestibular disorders. [unreadable] [unreadable] [unreadable]..
  45. MORPHOLOGIC BASIS FOR CENTRAL VESTIBULAR INHIBITION
    GAY HOLSTEIN; Fiscal Year: 2002
    ....
  46. FUNCTIONAL GENOMICS OF HEARING
    Zheng Yi Chen; Fiscal Year: 2005
    ..1, and should establish a model for studying hair cell development controlled by other transcription factors such as Math1. ..
  47. VESTIBULAR SOMATOSENSORY INTERACTIONS FOR HUMAN POSTURE
    Fay Horak; Fiscal Year: 2002
    ....
  48. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  50. In Vitro Analysis of Embryonic Inner Ear Cells
    LYNNE BIANCHI; Fiscal Year: 2002
    ..Together, these experiments will provide information regarding the mechanisms used for organizing normal auditory and vestibular epithelia and may provide insight into means of treating congenital anomalies of the inner ear...
  51. NEURAL BASIS OF SPATIAL COGNITION
    JEFFREY TAUBE; Fiscal Year: 2003
    ..Learning how spatial information is processed in the rat brain will give us clues about the complex nature of spatial processes in humans. ..
  52. K+ CHANNEL MODEL FOR TRINUCLEOTIDE-EXPANSION DISEASES
    George Chandy; Fiscal Year: 2002
    ....
  53. Scaling in Reflexive and Volitional Eye Movements
    Mark Shelhamer; Fiscal Year: 2006
    ..Since scaling changes with pathology, new means to assess vestibular or oculomotor pathology may result. ..
  54. Cerebellar Afferent Integration Studied In Vitro
    Michael Ariel; Fiscal Year: 2007
    ..This in vitro preparation will thereby provide a unique model system for the study of learning and adaptation of motor behaviors. [unreadable] [unreadable]..
  55. Improved Search Coil Method for Measuring Eye Movements
    Mark Shelhamer; Fiscal Year: 2007
    ..abstract_text> ..
  56. Neurotransmission at the vestibular calyx synapse
    KATHERINE RENNIE; Fiscal Year: 2007
    ..The combination of experimental & modeling approaches will elucidate how sensory information is transformed by HC1 & converted into a neural code by their afferents. ..
  57. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..abstract_text> ..
  58. MOLECULAR BASIS FOR Kv CHANNEL HETEROGENEITY IN THE HEART
    Gea Ny Tseng; Fiscal Year: 2010
    ..These models will be useful in structure-based design of IKs activators that can combat acquired &congenital LQT syndromes. ..
  59. Neural mechanisms of 3-D linear vestibuloocular reflex
    Chiju Chen Huang; Fiscal Year: 2009
    ..abstract_text> ..
  60. NEURAL MECHANISMS OF DIRECTIONAL ORIENTATION
    JEFFREY TAUBE; Fiscal Year: 2004
    ....
  61. K CHANNELS: STRUCTURE-FUNCTION RELATION AND MODULATION
    Gea Ny Tseng; Fiscal Year: 2006
    ..in the ion channel field, help shape the current proposal, which has 3 Specific Aims: (1) Probing the outer vestibule structure of the HERG channel...