semicircular canals

Summary

Summary: Three long canals (anterior, posterior, and lateral) of the labyrinth. They are set at right angles to each other and are situated superior and posterior to the vestibule.

Top Publications

  1. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
  2. pmc Semicircular canals and agility: the influence of size and shape measures
    Philip G Cox
    Division of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Liverpool, UK
    J Anat 216:37-47. 2010
  3. ncbi Impulsive testing of semicircular-canal function using video-oculography
    Konrad P Weber
    Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann N Y Acad Sci 1164:486-91. 2009
  4. ncbi Probing the human vestibular system with galvanic stimulation
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
    J Appl Physiol (1985) 96:2301-16. 2004
  5. ncbi Ocular vestibular evoked myogenic potentials in superior canal dehiscence
    S M Rosengren
    UNSW Clinical School and Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia
    J Neurol Neurosurg Psychiatry 79:559-68. 2008
  6. ncbi CT evaluation of bone dehiscence of the superior semicircular canal as a cause of sound- and/or pressure-induced vertigo
    Clifford J Belden
    Department of Radiology, Brooke Army Medical Center, San Antonio, TX, USA
    Radiology 226:337-43. 2003
  7. ncbi Netrin 1 is required for semicircular canal formation in the mouse inner ear
    M Salminen
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 127:13-22. 2000
  8. pmc Do agility and skull architecture influence the geometry of the mammalian vestibulo-ocular reflex?
    Nathan Jeffery
    Division of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Anat 216:496-509. 2010
  9. pmc Disruption of the head direction cell signal after occlusion of the semicircular canals in the freely moving chinchilla
    Gary M Muir
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurosci 29:14521-33. 2009
  10. pmc Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear
    Victoria E Abraira
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 135:4091-9. 2008

Detail Information

Publications233 found, 100 shown here

  1. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    Angular head movements in vertebrates are detected by the three semicircular canals of the inner ear and their associated sensory tissues, the cristae...
  2. pmc Semicircular canals and agility: the influence of size and shape measures
    Philip G Cox
    Division of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Liverpool, UK
    J Anat 216:37-47. 2010
    The semicircular canals of the inner ear sense angular accelerations and decelerations of the head and enable co-ordination of posture and body movement, as well as visual stability...
  3. ncbi Impulsive testing of semicircular-canal function using video-oculography
    Konrad P Weber
    Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann N Y Acad Sci 1164:486-91. 2009
    ..This system is easy to use in a clinical setting, provides an objective measure of the vestibulo-ocular reflex (VOR), and detects both overt and covert catch-up saccades in patients with vestibular loss...
  4. ncbi Probing the human vestibular system with galvanic stimulation
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
    J Appl Physiol (1985) 96:2301-16. 2004
    ..On the basis of the morphology of the cristae and the alignment of the semicircular canals in the skull, rotational vectors calculated for every mode of GVS agree with the observed sway...
  5. ncbi Ocular vestibular evoked myogenic potentials in superior canal dehiscence
    S M Rosengren
    UNSW Clinical School and Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia
    J Neurol Neurosurg Psychiatry 79:559-68. 2008
    ....
  6. ncbi CT evaluation of bone dehiscence of the superior semicircular canal as a cause of sound- and/or pressure-induced vertigo
    Clifford J Belden
    Department of Radiology, Brooke Army Medical Center, San Antonio, TX, USA
    Radiology 226:337-43. 2003
    ..To describe the computed tomographic (CT) findings at different collimation widths associated with superior semicircular canal (SSC) dehiscence syndrome and to determine the frequency of these findings in a control population...
  7. ncbi Netrin 1 is required for semicircular canal formation in the mouse inner ear
    M Salminen
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 127:13-22. 2000
    ..epithelium, in cells that will come together to form a fusion plate, a prerequisite for the formation of semicircular canals. In netrin 1 mutant mice, fusion plate formation is severely affected resulting in a reduced anterior ..
  8. pmc Do agility and skull architecture influence the geometry of the mammalian vestibulo-ocular reflex?
    Nathan Jeffery
    Division of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Anat 216:496-509. 2010
    The spatial arrangement of the semicircular canals and extraocular muscles of the eye has been of considerable interest, particularly to researchers working on adaptations of the vestibulo-ocular reflex...
  9. pmc Disruption of the head direction cell signal after occlusion of the semicircular canals in the freely moving chinchilla
    Gary M Muir
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurosci 29:14521-33. 2009
    ..To assess the specific contributions of the semicircular canals without altering tonic VIIIth nerve input, ADN cells were recorded from chinchillas after bilateral ..
  10. pmc Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear
    Victoria E Abraira
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 135:4091-9. 2008
    The sense of balance depends on the intricate architecture of the inner ear, which contains three semicircular canals used to detect motion of the head in space...
  11. pmc Planar relationships of the semicircular canals in two strains of mice
    Daniel R Calabrese
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 South Euclid Avenue 8115, Saint Louis, MO 63110, USA
    J Assoc Res Otolaryngol 7:151-9. 2006
    ..many studies have focused on the vestibular responses of mice to angular rotation, the geometry of their semicircular canals has not been described...
  12. ncbi Relationship of semicircular canal size to vestibular-nerve afferent sensitivity in mammals
    Aizhen Yang
    Department of Otolaryngology, Head and Neck Surgery, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    J Neurophysiol 98:3197-205. 2007
    ..5-Hz rotations is likely to be about 0.67 spike . s(-1)/deg . s(-1) and of their high-gain irregular afferents about 1.06 spikes . s(-1)/deg . s(-1)...
  13. ncbi Genetic modification of the inner ear lateral semicircular canal phenotype of the Bmp4 haplo-insufficient mouse
    Raf Vervoort
    Laboratory of Glycobiology and Developmental Genetics, Flanders Institute for Biotechnology VIB and Department of Human Genetics, Katholieke Universiteit Leuven, Herestraat 49 bus 602, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 394:780-5. 2010
    ..Candidate genes to contain the causal mutation are Bmp4 on chromosome 14, and Rere on chromosome 4...
  14. ncbi Vestibular-evoked myogenic potentials in patients with dehiscence of the superior semicircular canal
    K Brantberg
    Department of Audiology, Karolinska Hospital, Stockholm, Sweden
    Acta Otolaryngol 119:633-40. 1999
    ....
  15. ncbi Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo
    Teppei Noda
    Department of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Dev Biol 362:83-93. 2012
    ..The semicircular canals of the vestibule form from the periphery of the outpocketings, with the central region (the fusion plate) ..
  16. ncbi Semicircular canal system in early primates
    Mary T Silcox
    Department of Anthropology, University of Winnipeg, Winnipeg, Canada
    J Hum Evol 56:315-27. 2009
    Mammals with more rapid and agile locomotion have larger semicircular canals relative to body mass than species that move more slowly...
  17. pmc The evolution of bat vestibular systems in the face of potential antagonistic selection pressures for flight and echolocation
    Kalina T J Davies
    School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
    PLoS ONE 8:e61998. 2013
    ..First, bats are capable of powered flight, which in birds is associated with enlarged semicircular canals. Second, many bats have enlarged cochleae associated with echolocation, and both cochleae and semicircular ..
  18. ncbi Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation
    Marta Martini
    Dipartimento di Biologia ed Evoluzione, Sezione di Fisiologia e Biofisica, e Centro di Neuroscienze, Universita di Ferrara, Via L Borsari 46, Ferrara, Italy
    Eur Biophys J 36:779-86. 2007
    Some aspects of Ca(2+) channel modulation in hair cells isolated from semicircular canals of the frog (Rana esculenta) have been investigated using the whole-cell technique and intra and extracellular solutions designed to modify the ..
  19. pmc Analysis of intraindividual and intraspecific variation in semicircular canal dimensions using high-resolution x-ray computed tomography
    Kelli L Welker
    Department of Anthropology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Anat 215:444-51. 2009
    ..of this study was to investigate the intraspecific and intraindividual variation in the size of the three semicircular canals. The right and left temporal bones were extracted from 31 individuals of the short-tailed shrew (Blarina ..
  20. pmc Mechanical amplification by hair cells in the semicircular canals
    Richard D Rabbitt
    University of Utah, Salt Lake City, UT 84013, USA
    Proc Natl Acad Sci U S A 107:3864-9. 2010
    ..The biophysical basis of the motor(s) remains hypothetical, but a key discriminating question may involve how changes in somatic electrical impedance evoked by efferent synaptic action alter function of the motor(s)...
  21. ncbi Individual semicircular canal function in superior and inferior vestibular neuritis
    S T Aw
    Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
    Neurology 57:768-74. 2001
    ..To examine the concept of selective superior and inferior vestibular nerve involvement in vestibular neuritis by studying the distribution of semicircular canal (SCC) involvement in such patients...
  22. ncbi The interpretation of clinical tests of peripheral vestibular function
    Ian S Curthoys
    Vestibular Research Laboratory, School of Psychology, University of Sydney, Sydney, New South Wales, Australia
    Laryngoscope 122:1342-52. 2012
    ....
  23. pmc Locomotor head movements and semicircular canal morphology in primates
    Michael D Malinzak
    Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 109:17914-9. 2012
    Animal locomotion causes head rotations, which are detected by the semicircular canals of the inner ear...
  24. ncbi Effect of semicircular canal stimulation on the perception of the visual vertical
    Marousa Pavlou
    Academic Department of Neuro Otology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London W6 8RF, United Kingdom
    J Neurophysiol 90:622-30. 2003
    ....
  25. pmc Geometry of the semicircular canals and extraocular muscles in rodents, lagomorphs, felids and modern humans
    Philip G Cox
    Division of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Anat 213:583-96. 2008
    ..reflex (VOR) exacts compensatory movements of the extraocular muscles in response to stimulation of the semicircular canals to allow gaze fixation during head movements...
  26. ncbi The primate subarcuate fossa and its relationship to the semicircular canals part II: adult interspecific variation
    Nathan Jeffery
    Department of Human Anatomy and Cell Biology, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    J Hum Evol 55:326-39. 2008
    Studies have reported an empirical link between the size of the semicircular canals and locomotor agility across adult primates...
  27. ncbi Anatomo-radiological study of the Superior Semicircular Canal Dehiscence Radiological considerations of Superior and Posterior Semicircular Canals
    M Crovetto
    Otolaryngology Department, Hospital de Basurto, University of the Basque Country, Avenida de Montevideo 18, Bilbao, Vizcaya, Spain
    Eur J Radiol 76:167-72. 2010
    ..We have also analysed the relation between the ossification state of the semicircular canals and the degree of mastoid pneumatization and integrity of Tegmen Tympani.
  28. ncbi Ionic currents in hair cells dissociated from frog semicircular canals after preconditioning under microgravity conditions
    Marta Martini
    Department of Biology and Evolution, Section of Physiology and Biophysics, and National Institute of Neuroscience, Ferrara University, I 44100 Ferrara, Italy
    Am J Physiol Regul Integr Comp Physiol 296:R1585-97. 2009
    ....
  29. pmc Prenatal growth and development of the modern human labyrinth
    Nathan Jeffery
    Department of Human Anatomy and Cell Biology, University of Liverpool, UK
    J Anat 204:71-92. 2004
    ..Findings are discussed in terms of the ontogenetic processes and mechanisms that most likely led, in part, to the emergence of the phylogenetically derived adult modern human labyrinth...
  30. ncbi Semicircular canal function before and after surgery for superior canal dehiscence
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 28:356-64. 2007
    ..To characterize semicircular canal function before and after surgery for superior semicircular canal dehiscence (SCD) syndrome...
  31. ncbi The 2D modified head impulse test: a 2D technique for measuring function in all six semi-circular canals
    Americo A Migliaccio
    Neuroscience Research Australia and the University of New South Wales, Sydney, Australia
    J Vestib Res 21:227-34. 2011
    The head impulse test can be used to measure peripheral vestibular function of all six semicircular canals. Traditionally, vertical canal function is measured by rotating the head from a starting neutral position (forward facing) about a ..
  32. pmc Inner ear of a notoungulate placental mammal: anatomical description and examination of potentially phylogenetically informative characters
    Thomas E Macrini
    Department of Vertebrate Paleontology, Division of Paleontology, American Museum of Natural History, New York, NY, USA
    J Anat 216:600-10. 2010
    ..We also assess the locomotor agility of Notostylops based on measurements of the semicircular canals. This is the best available data on the locomotion of a notostylopid because significant postcranial ..
  33. ncbi The EMG development of the longissimus and multifidus muscles after plugging the horizontal semicircular canals
    H C Geisler
    J Vestib Res 8:399-409. 1998
    The effects of plugging both horizontal semicircular canals at the 5th postnatal day (P5) on the development of the EMG of two back muscles (the M. longissimus lateralis and the M. multifidus) were studied in rats between P5 and P46...
  34. ncbi Posture control in Pusher syndrome: influence of lateral semicircular canals
    Taiza Elaine Grespan dos Santos Pontelli
    Braz J Otorhinolaryngol 71:448-52. 2005
    ..The role of vestibular system on the pushing behavior is not clear...
  35. ncbi IP3 receptor in the hair cells of frog semicircular canal and its possible functional role
    Maria Lisa Rossi
    Dipartimento di Biologia, Sezione di Fisiologia e Biofisica, Centro di Neuroscienze, Via L Borsari, 46, I 44100, Ferrara, Italy
    Eur J Neurosci 23:1775-83. 2006
    ..Our results indicate the presence and a possibly relevant functional role of IP3-sensitive stores in controlling [Ca2+]i and modulating the vestibular discharge...
  36. ncbi Transmitter release from Rana pipiens vestibular hair cells via mGluRs: a role for intracellular Ca(++) release
    Adam W Hendricson
    Division of Pharmacology Toxicology, University of Texas at Austin College of Pharmacy, 2409 University Ave, PHR 5 214, Austin, TX 78712, USA
    Hear Res 172:99-109. 2002
    ....
  37. ncbi Congenital aplasia of the semicircular canals
    Bulent Satar
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Otol Neurotol 24:437-46. 2003
    To describe the underrecognized inner ear malformation characterized by complete aplasia of the labyrinthine semicircular canals associated with a relatively well-formed cochlea, to investigate its relationship with known syndromic forms ..
  38. pmc Otolith and canal reflexes in human standing
    Ian Cathers
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 563:229-34. 2005
    We used galvanic vestibular stimulation (GVS) to identify human balance reflexes of the semicircular canals and otolith organs...
  39. ncbi Horizontal canal benign positional vertigo
    Jeremy Hornibrook
    Department of Otolaryngology Head and Neck Surgery, Christchurch Hospital, Christchurch, New Zealand
    Ann Otol Rhinol Laryngol 113:721-5. 2004
    ..The mechanism can be canalithiasis or cupulolithiasis. Repositioning treatment is a 360 degrees horizontal head and body rotation that has a high success rate if the symptomatic ear is correctly identified...
  40. ncbi Short-latency eye movements evoked by near-threshold galvanic vestibular stimulation
    Alexandra Séverac Cauquil
    Centre de Recherche Cerveau and CognitionUMR 5549 CNRS Université Paul Sabatier, Toulouse, France
    Exp Brain Res 148:414-8. 2003
    ..The overall pattern of eye movement suggests that semicircular canal afferents contribute to these low-intensity GVS responses...
  41. ncbi Benign paroxysmal positional vertigo
    J M Furman
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA 15213, USA
    N Engl J Med 341:1590-6. 1999
    ..Although many patients with positionally provoked vertigo have typical benign paroxysmal positional vertigo, physicians should be aware of nonbenign variants...
  42. ncbi Sound- and/or pressure-induced vertigo due to bone dehiscence of the superior semicircular canal
    L B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21203 6402, USA
    Arch Otolaryngol Head Neck Surg 124:249-58. 1998
    ..To describe anatomical findings and outcome in 2 patients undergoing plugging of the superior semicircular canal for treatment of these symptoms...
  43. ncbi Auditory function in patients with surgically treated superior semicircular canal dehiscence
    Charles J Limb
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Otol Neurotol 27:969-80. 2006
    ..To characterize preoperative and postoperative audiologic findings in patients with superior semicircular canal dehiscence syndrome...
  44. ncbi Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish
    Brian Blasiole
    Department of Pharmacology, Penn State University College of Medicine, H078, Hershey, PA 17033, USA
    Dev Biol 294:148-60. 2006
    ..Knockdown of a second zebrafish alpha subunit, alpha1a.2, disrupted development of the semicircular canals. Knockdown of Na,K-ATPase beta2b expression also caused an otolith defect, suggesting that the beta2b ..
  45. ncbi Nystagmus during neck flexion in the pitch plane in benign paroxysmal positional vertigo involving the horizontal canal
    Seung Han Lee
    Department of Neurology, Chonnam National University Medical School, 8 Hak Dong, Dong Gu, Gwangju, South Korea
    J Neurol Sci 256:75-80. 2007
    ..In benign paroxysmal positional vertigo involving the horizontal canal (HC-BPPV), nystagmus may be induced by neck flexion in the pitch plane while sitting (head-bending nystagmus)...
  46. ncbi Dehiscence of bone overlying the superior canal as a cause of apparent conductive hearing loss
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Otol Neurotol 24:270-8. 2003
    ..To identify patients with superior semicircular canal dehiscence and apparent conductive hearing loss and to define the cause of the air-bone gap...
  47. pmc Rotational responses of vestibular-nerve afferents innervating the semicircular canals in the C57BL/6 mouse
    David M Lasker
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Ross Building Suite 710, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Assoc Res Otolaryngol 9:334-48. 2008
    Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice ranging in age from 4-24 weeks...
  48. pmc The effect of superior-canal opening on middle-ear input admittance and air-conducted stapes velocity in chinchilla
    Jocelyn E Songer
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 120:258-69. 2006
    ..In six ears a statistically significant reversible increase in stapes velocity was observed. Both of these changes are consistent with the hole creating a shunt pathway that increases the cochlear input admittance...
  49. ncbi Treatment of apogeotropic benign positional vertigo: comparison of therapeutic head-shaking and modified Semont maneuver
    S Y Oh
    Department of Neurology, School of Medicine, Chonbuk National University, Jeonju, South Korea
    J Neurol 256:1330-6. 2009
    ..The head-shaking maneuver described here proved more effective than the modified Semont maneuver in treating apogeotropic HC-BPV. Mastoid vibration conferred no additional benefit during the Brandt-Daroff exercise...
  50. ncbi Involvement of programmed cell death in morphogenesis of the vertebrate inner ear
    D M Fekete
    Department of Biology, Boston College, Chestnut Hill, MA 02167, USA
    Development 124:2451-61. 1997
    ..which acquires a precise three-dimensional arrangement of its constituent epithelial cells to form three semicircular canals, a central vestibule and a coiled cochlea (in mammals)...
  51. ncbi Superior vestibular neurectomy: a novel transmeatal approach for a denervation of the superior and lateral semicircular canals
    Georg C Feigl
    Institute of Anatomy, Medical University Graz, Graz, Austria
    Otol Neurotol 30:586-91. 2009
    ....
  52. pmc Determinants of spatial and temporal coding by semicircular canal afferents
    Stephen M Highstein
    Washington University School of Medicine, Department of Otolaryngology, St Louis, MO 63110, USA
    J Neurophysiol 93:2359-70. 2005
    The vestibular semicircular canals are internal sensors that signal the magnitude, direction, and temporal properties of angular head motion...
  53. ncbi Glucocorticoid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat
    Satyanarayana R Pondugula
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
    Physiol Genomics 24:114-23. 2006
    ..These findings are consistent with the genomic stimulation by glucocorticoids of Na+ absorption by SCCD and provide an understanding of the therapeutic action of glucocorticoids in the treatment of Meniere's disease...
  54. ncbi Benign paroxysmal positional vertigo due to a simultaneous involvement of both horizontal and posterior semicircular canals
    Takao Imai
    Department of Otolaryngology, Kansai Rosai Hospital, Hyogo, and Department of Otolaryngology, Osaka Universityu Medical School, Japan
    Audiol Neurootol 11:198-205. 2006
    ..positional vertigo (BPPV) that was suspected to simultaneously affect both the horizontal and posterior semicircular canals (HSCC and PSCC)...
  55. ncbi Effects of galvanic vestibular stimulation on otolithic and semicircular canal eye movements and perceived vertical
    R Zink
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Electroencephalogr Clin Neurophysiol 107:200-5. 1998
    ..The aim of this study was to determine the otolithic and semicircular canal effects of galvanic vestibular stimulation with increasing current strengths on eye movements and the perception of verticality...
  56. ncbi EphB2 guides axons at the midline and is necessary for normal vestibular function
    C A Cowan
    Center for Developmental Biology, University of Texas, Southwestern Medical Center, Dallas 75235, USA
    Neuron 26:417-30. 2000
    ..inappropriate pathway selection at the midline, while in mutant adults, the endolymph-filled lumen of the semicircular canals is severely reduced...
  57. ncbi Circling behavior in the Ecl mouse is caused by lateral semicircular canal defects
    Kim Cryns
    Department of Medical Genetics, University of Antwerp, 2610 Antwerp, Belgium
    J Comp Neurol 468:587-95. 2004
    ..Investigation of the vestibuloocular reflex (VOR) in Ecl mice showed that their horizontal VOR on stimulation is virtually absent, which correlates with the morphological findings...
  58. ncbi Resolving head rotation for human bipedalism
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney 2031, Australia
    Curr Biol 16:1509-14. 2006
    ..However, changes to the semicircular canals during human evolution suggest that the sense of head rotation that they provide is important for modern ..
  59. pmc A mathematical model of human semicircular canal geometry: a new basis for interpreting vestibular physiology
    Andrew P Bradshaw
    School of Electrical Engineering, The University of New South Wales, Sydney, Australia
    J Assoc Res Otolaryngol 11:145-59. 2010
    ..and accessible method of mathematically measuring and modeling the three-dimensional (3D) geometry of semicircular canals (SCCs) in living humans...
  60. pmc Efferent control of hair cell and afferent responses in the semicircular canals
    Richard Boyle
    NASA Ames Research Center, BioVIS Center, M S 239 11, Moffett Field, CA 94035, USA
    J Neurophysiol 102:1513-25. 2009
    ..In the semicircular canals, brain stem efferent neurons make synaptic contacts with mechanosensory hair cells and with the dendrites ..
  61. ncbi Absent semicircular canals in CHARGE syndrome: radiologic spectrum of findings
    A K Morimoto
    Department of Radiology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    AJNR Am J Neuroradiol 27:1663-71. 2006
    ..With this information, neuroradiologists will be better prepared to provide clinically relevant information to their referring physicians regarding this rare syndrome...
  62. ncbi Three-dimensional biomechanical model of benign paroxysmal positional vertigo
    Suhrud M Rajguru
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Ann Biomed Eng 32:831-46. 2004
    ..Results further illustrate the effectiveness of the Epley CRP in repositioning the particles and relieving the symptoms of the canalithiasis type of BPPV...
  63. ncbi Impulsive testing of semicircular canal function
    G Michael Halmagyi
    Neurology Department, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
    Prog Brain Res 171:187-94. 2008
    ..in response to high-acceleration, off-direction stimulation of the sole functioning member of any pair of semicircular canals. For the clinician, impulsive testing is an easy and reliable way to identify severe unilateral as well as ..
  64. ncbi Properties and axonal trajectories of posterior semicircular canal nerve-activated vestibulospinal neurons
    Keisuke Kushiro
    Department of Human and Environmental Studies, Kyoto University, Yoshida nihonmatsu cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Brain Res 191:257-64. 2008
    ....
  65. ncbi A new quantitative model of total endolymph flow in the system of semicircular ducts
    M Muller
    Department of Experimental Animal Morphology and Cell Biology, Agricultural University, Wageningen, The Netherlands
    J Theor Biol 134:473-501. 1988
    ..4. The present theory of endolymph flow is mainly supported by the outcome of previously performed experiments concerning time constants and rotation of human subjects in different planes.(ABSTRACT TRUNCATED AT 400 WORDS)..
  66. ncbi Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal
    Daisuke Yamauchi
    Cellular Biophysics Laboratory, Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
    Biochem Biophys Res Commun 331:1353-7. 2005
    ..These observations provide evidence for the first time of an ECaC-based Ca2+ transport system in SCCD that could maintain the low Ca2+ concentration in vestibular endolymph...
  67. pmc Vestibulo-ocular responses evoked via bilateral electrical stimulation of the lateral semicircular canals
    Wangsong Gong
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 55:2608-19. 2008
    ..responses (VORs) evoked by bilateral electrical stimulation of the nerves innervating horizontal semicircular canals in squirrel monkeys and compared these responses to those evoked by unilateral stimulation...
  68. ncbi Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation
    Erich Schneider
    Department of Neurology with Center for Sensorimotor Research, Klinikum Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    J Neurophysiol 87:2064-73. 2002
    ..Thus we conclude that both the tonic and the phasic OT responses to GVS can be reproduced by pure rotational stimulations and that the OT-related effects of GVS on SCC afferents are similar to natural stimulations at small amplitudes...
  69. pmc The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
    Tiia Ponnio
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:935-45. 2002
    ..expression in the vestibule is limited to nonsensory epithelial cells localized at the inner edge of the semicircular canals and to the ampullary and utricular walls...
  70. pmc Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstruction
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 6:191-206. 2005
    ..reflex experiments requires knowledge of the absolute orientations (with respect to skull landmarks) of semicircular canals (SCC)...
  71. ncbi Chloride secretion by semicircular canal duct epithelium is stimulated via beta 2-adrenergic receptors
    Pierre G Milhaud
    Institut National de la Santé et de la Recherche Médicale Unité 432 Vestibular Neurobiology, Universite Montpellier II, 34095 Montpellier, France
    Am J Physiol Cell Physiol 283:C1752-60. 2002
    ..The current work points to one possible etiology of endolymphatic hydrops in Meniere's disease and may provide a basis for intervention...
  72. ncbi Examination of the cupula and stereocilia of the horizontal semicircular canal in the toadfish Opsanus tau
    R B Silver
    Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    J Comp Neurol 402:48-61. 1998
    ..Connective tissue fibers may serve to stiffen the gel, whose matrix would restrict lateral motion of embedded fibers and stereocilia thereby providing mechanical support for stereocilia...
  73. ncbi Comparative morphology of rodent vestibular periphery. II. Cristae ampullares
    Sapan S Desai
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, M C 512 808 S Wood St, Room 578, Chicago, IL 60612, USA
    J Neurophysiol 93:267-80. 2005
    ..Apart from this eminentia cruciatum, there are no statistical differences between horizontal and vertical cristae with regard to area, width, length, the number and type of hair cells, and number of calretinin-labeled calyx afferents...
  74. ncbi Axial specification for sensory organs versus non-sensory structures of the chicken inner ear
    D K Wu
    National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
    Development 125:11-20. 1998
    ..The asynchronous specification of the A/P and D/V axes of the chick inner ear suggests that sensory organ formation is a multi-step phenomenon, rather than a single inductive event...
  75. pmc Semicircular canal geometry, afferent sensitivity, and animal behavior
    Timothy E Hullar
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:466-72. 2006
    The geometry of the semicircular canals has been used in evolutionary studies to predict the behaviors of extinct animals...
  76. ncbi 3-T imaging of the cochlear nerve and labyrinth in cochlear-implant candidates: 3D fast recovery fast spin-echo versus 3D constructive interference in the steady state techniques
    John I Lane
    Department of Radiology, Mayo Clinic, Rochester, MN, USA
    AJNR Am J Neuroradiol 25:618-22. 2004
    ..5 T is often performed by using three-dimensional (3D) fast spin-echo or T2* techniques. We evaluated both techniques at 3 T in the preoperative assessment of patients being considered for cochlear implants...
  77. pmc The contribution of otoliths and semicircular canals to the perception of two-dimensional passive whole-body motion in humans
    Y P Ivanenko
    Laboratoire de Physiologie de la Perception et de l Action, CNRS College de France, Paris, France
    J Physiol 502:223-33. 1997
    ..4. The curvature of the drawn paths was mostly explained by the input to the semicircular canals. Subjects' reconstruction of motion did not account for the directional dynamics of the input to the ..
  78. ncbi Nkx5-1 controls semicircular canal formation in the mouse inner ear
    T Hadrys
    Technical University Braunschweig, Department of Cell and Molecular Biology, Germany
    Development 125:33-9. 1998
    ..with severe malformations of the vestibular organ in Nkx5-1(-/-) mutants, which fail to develop the semicircular canals. Nkx5-1 is the first ear-specific molecule identified to play a crucial role in the formation of the ..
  79. ncbi Neural processing of gravito-inertial cues in humans. I. Influence of the semicircular canals following post-rotatory tilt
    L H Zupan
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 84:2001-15. 2000
    ..The vestibular system includes two types of sensors: the semicircular canals, which measure head rotation, and the otolith organs, which measure gravito-inertial force (GIF), the sum ..
  80. ncbi Dopaminergic modulation of afferent synaptic transmission in the semicircular canals of frogs
    G N Andrianov
    Pavlov Institute of Physiology of the Russian Academy of Sciences, St Petersburg, Russia
    Neurosignals 17:222-8. 2009
    ....
  81. ncbi Magnetic resonance cisternography: comparison between 3-dimensional driven equilibrium with sensitivity encoding and 3-dimensional balanced fast-field echo sequences with sensitivity encoding
    Na Young Jung
    Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Korea
    J Comput Assist Tomogr 31:588-91. 2007
    ....
  82. ncbi Neural processing of gravito-inertial cues in humans. II. Influence of the semicircular canals during eccentric rotation
    D M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 85:1648-60. 2001
    ..More generally, these findings are consistent with the hypothesis that the nervous system uses internal models to process and interpret sensory motor cues...
  83. ncbi Benign paroxysmal positional vertigo: concomitant involvement of different semicircular canals
    Andreza Tomaz
    Department of Human Communication Disorders, Federal University of Sao Paulo, Brazil
    Ann Otol Rhinol Laryngol 118:113-7. 2009
    We evaluated the simultaneous ipsilateral or contralateral involvement of the posterior and lateral, anterior and lateral, or posterior and anterior semicircular canals in patients with benign paroxysmal positional vertigo (BPPV).
  84. pmc Afferent responses during experimentally induced semicircular canalithiasis
    Suhrud M Rajguru
    Department of Bioengineering, University of Utah, 20 South 2030 East, Rm 506, Salt Lake City, UT 84112, USA
    J Neurophysiol 97:2355-63. 2007
    ..The magnitude and time course of the responses reported here are sufficient to explain the symptoms of BPPV...
  85. pmc Hair-cell versus afferent adaptation in the semicircular canals
    R D Rabbitt
    University of Utah, Dept of Bioengineering, 20 South, 2030 East Room 506 BPRB, Salt Lake City, UT 84112, USA
    J Neurophysiol 93:424-36. 2005
    ....
  86. pmc Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis
    P Bertholon
    CHU de Saint Etienne, Hopital Bellevue, Saint Etienne, France
    J Neurol Neurosurg Psychiatry 72:366-72. 2002
    ..To clarify the clinical significance of positional down beat nystagmus (pDBN)...
  87. ncbi Multiple dehiscence of semicircular canals
    D Rajenderkumar
    Department of Audiological Medicine, Nose and Ear Hospital, London, UK
    J Laryngol Otol 121:80-2. 2007
    ..We describe a case with dehiscence of four semicircular canals and in areas not involving the roof of the superior semicircular canal...
  88. ncbi Nature and expression of dihydropyridine-sensitive and -insensitive calcium currents in hair cells of frog semicircular canals
    Giancarlo Russo
    Dipartimento di Scienze Fisiologiche Farmacologiche Cellulari Molecolari, Universita di Pavia, Via Forlanini 6, 27100, Pavia, Italy
    Pflugers Arch 446:189-97. 2003
    ..Finally, immunocytochemical investigations revealed the presence of Ca(2+) channel subunits of the alpha(1D) type and the unexpected expression of alpha(1B)-subunits...
  89. ncbi Directional coding of three-dimensional movements by the vestibular semicircular canals
    R D Rabbitt
    Department of Bioengineering, University of Utah Salt Lake City 84112, USA
    Biol Cybern 80:417-31. 1999
    ..Results may have implications regarding the central representation of angular head movements in space as well as the neuronal mappings between three-canal afferent inputs and motor outputs...
  90. pmc The role of bone morphogenetic protein 4 in inner ear development and function
    Marsha N Blauwkamp
    Cellular and Molecular Biology Program, 2966 Taubman Medical Library, University of Michigan, Ann Arbor, MI 48109 0619, USA
    Hear Res 225:71-9. 2007
    ..Thus Bmp4(+/-) mice have structural and functional deficits in the inner ear...
  91. ncbi Clinical features of paroxysmal positional vertigo presenting combined lesions
    M Suzuki
    Department of Otolaryngology, Tokyo Medical University, Japan
    Acta Otolaryngol 119:117-20. 1999
    ..Combined CRP was performed on these cases, which again gave good clinical results. Other BPPV cases were associated with central lesions. We must be aware that BPPV may involve multiple canals and may be associated with central lesions...
  92. pmc Search-coil head-thrust and caloric tests in Ménière's disease
    Hong Ju Park
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Acta Otolaryngol 125:852-7. 2005
    ..In these subjects, the head-thrust test (HTT) may not be as sensitive to canal dysfunction as traditional caloric testing. MD may differentially affect the low-frequency sensitivity of the canals...
  93. ncbi Otolith deprivation induces optokinetic compensation
    Corina E Andreescu
    Department of Neuroscience, Erasmus University Medical Center Rotterdam, DR Rotterdam, The Netherlands
    J Neurophysiol 94:3487-96. 2005
    ....
  94. doi Practice parameter: simple maneuver is best therapy for common form of vertigo
    Mike Mitka
    JAMA 300:157-8. 2008
  95. ncbi Effect of angular acceleration on the localization performance of a remembered target
    Frank Schmäl
    Department of Otorhinolaryngology, University Hospital Munster, Germany
    J Vestib Res 15:81-92. 2005
    ....
  96. ncbi 'Bow and lean test' to determine the affected ear of horizontal canal benign paroxysmal positional vertigo
    Yun Hoon Choung
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
    Laryngoscope 116:1776-81. 2006
    ..The purpose of this study is to develop the new "bow and lean test (BLT)" to easily determine the affected ear of HSC-BPPV and evaluate its efficiency...
  97. ncbi Benign paroxysmal positional vertigo can interfere with the cardiac response to head-down tilt
    Kathrine Jáuregui-Renaud
    Unidad de Investigación Médica HG CMN La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Otol Neurotol 26:484-8. 2005
    ..To assess the pulse rate and the respiratory rate responses to head-down tilt of the whole body in the plane of the posterior canals in healthy subjects and in patients with benign paroxysmal positional vertigo (BPPV)...
  98. ncbi Semicircular canal plugging shifts the frequency of spatial-temporal convergence (STC) in central vestibular neurons
    Sergei B Yakushin
    Mount Sinai School of Medicine, Neurology Dept, Box 1135, 5E 98 Street, New York, NY 10029, USA
    J Gravit Physiol 14:P71-2. 2007
  99. ncbi [Horizontal canal benign paroxysmal positional vertigo--its affected side and horizontal semicircular canal function]
    Nobuya Fujita
    Department of Otolaryngology, Nara Medical University, Nara University
    Nihon Jibiinkoka Gakkai Kaiho 108:202-6. 2005
    ..The mechanism causing a difference in caloric test results between canalolithiasis and cupulolithiasis patients thus requires a larger patient population and further examination to be conclusive...
  100. ncbi Self-treatment for benign paroxysmal positional vertigo of the posterior semicircular canal
    Hitosh Tanimoto
    Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    Neurology 65:1299-300. 2005
    ..048). Complications occurred in 2.6% of the Epley-alone group and in 7.5% of the self-treatment group (p = 0.62)...
  101. pmc Diagnostic and treatment strategy of lateral semicircular canal canalolithiasis
    G Asprella Libonati
    Unit of Audiology Vestibology and Phoniatrics, Department of Otorhinolaryngology and Head Neck Surgery, Madonna delle Grazie Hospital, Matera, Italy
    Acta Otorhinolaryngol Ital 25:277-83. 2005
    ....

Research Grants62

  1. Sensory cell fate specification in the inner ear
    Douglas J Epstein; Fiscal Year: 2012
    ..and/or differentiation of hair cells and support cells in the organ of corti and cristae of the semicircular canals. Experiments in this proposal will further elaborate on the mechanisms by which Wnt/2catenin and Hh ..
  2. ROLE OF INHIBITION WITHIN THE CEREBELLAR NODULUS/UVULA IN VESTIBULAR PROCESSING
    TATYANA ALEKSANDROVNA YAKUSHEVA; Fiscal Year: 2012
    ..They process motion signals arriving from the vestibular organs (otoliths and semicircular canals), and send outputs to cerebellar and brainstem vestibular nuclei...
  3. Developmental Mechanisms of the Chromodomain Gene Chd7
    Donna M Martin; Fiscal Year: 2013
    ..Inner ear defects with Chd7 deficiency in mice are complex, and include malformations of the semicircular canals and innervation of sensory epithelia...
  4. Cellular and Molecular Mechanisms of Ear Morphogenesis
    Lisa V Goodrich; Fiscal Year: 2013
    ..are caused by defects in the development of the auditory system, ranging from a complete loss of the semicircular canals or cochlea to auditory circuitry deficits that interfere with sound perception...
  5. Biophysics and Biomechanics of the Semicircular Canals
    Richard D Rabbitt; Fiscal Year: 2013
    ..Results are expected to have long-term impact by enhancing understanding of semicircular canal micromechanics, cupulogenesis and self-repair, amplification by hair cells, and efferent control of motion sensation by the brain. ..
  6. Behavioral and physiological studies of sound localization
    Tom C T Yin; Fiscal Year: 2013
    ..aim will examine the vestibulo-auricular reflex by testing for the reflex following inactivation of the semicircular canals in the vestibular system...
  7. Central Neuronal Activity in Vestibular Compensation
    SHAWN NEWLANDS; Fiscal Year: 2009
    ..underlying recovery of the vestibulo-ocular reflex following unilateral labyrinthectomy or plugging of the semicircular canals. The study will consider compensation of vestibular response during both passive and active head movements...
  8. Vestibular Prosthesis Tested in a Vestibulopathic Model
    Richard F Lewis; Fiscal Year: 2012
    ..a prototype vestibular prosthesis which uses patterned electrical stimulation of the nerves innervating the semicircular canals in a non-human primate model...
  9. Vestibulo-spinal influences on reflex performance
    GREG GDOWSKI; Fiscal Year: 2009
    ..different combinations of voluntary and reflexive head movements only in the plane of the horizontal semicircular canals. Responses during voluntary and reflexive head movements will be quantified with respect to the response ..
  10. Neural mechanisms of 3-D linear vestibuloocular reflex
    Chiju Chen Huang; Fiscal Year: 2009
    ..Sensory inputs driving the AVOR and LVOR arise from different labyrinthine sensors (the semicircular canals and otolith organs, respectively)...
  11. MRI Induced Vertigo
    David S Zee; Fiscal Year: 2012
    ..We first plan to discover whether induction of electric currents, flow of fluids within the semicircular canals, or the diamagnetic properties of labyrinthine structures, is the likely cause of the magnetic field ..
  12. Vestibular Migraine Investigated with Psychophysical and Oculomotor Tests
    Richard F Lewis; Fiscal Year: 2013
    ..and oculomotor tests with the underlying hypothesis that the rotational information provided by the semicircular canals and the gravito-inertial information provided by the otolith organs are synthesized abnormally by the brain ..
  13. Vestibular Consequences of Blast-related Mild Traumatic Brain Injury
    FAITH AKIN; Fiscal Year: 2009
    ..and there is some evidence that head injury may affect the otolith organs to a greater degree than the semicircular canals. mTBI has been called the signature condition of veterans returning from Operation Enduring Freedom/..
  14. Mechanisms of signaling in otoconial organs
    Ellengene H Peterson; Fiscal Year: 2011
    ..There are two major subdivisions of the vestibular periphery: semicircular canals and otoconial organs. The former have been intensively studied...
  15. REGENERATION AND REINNERVATION OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 1999
    ..The semicircular canals (SCCs) will be studied...
  16. Vestibular Compensation During Volitional Head Movements
    SHAWN NEWLANDS; Fiscal Year: 2004
    ..recovery of the vestibulo-ocular reflex (VOR) following unilateral labyrinthectomy or plugging of the semicircular canals. Preliminary studies have investigated the role played by volition in compensatory ocular responses during ..
  17. PLASTICITY IN THE VESTIBULOOCULAR REFLEXES & PERCEPTION
    SCOTT SEIDMAN; Fiscal Year: 2003
    ..actually a set of reflexes activated by two forms of head acceleration; angular (the AVOR), driven by the semicircular canals, or linear (the LVOR), driven by the otoliths...
  18. VESTIBULAR NUCLEUS ACTIVITY IN VESTIBULAR COMPENSATION
    SHAWN NEWLANDS; Fiscal Year: 2003
    ..recovery of the vestibulo-ocular reflex (VOR) following unilateral labyrinthectomy or plugging of the semicircular canals. The role played by volition in compensatory ocular responses during head movement will be investigated by ..
  19. Stimulation model and experiments for a vestubular prosthesis.
    Gene Fridman; Fiscal Year: 2009
    ..is being activated by applying a rotation motion to the experimental subject or by directly stimulating the semicircular canals. Our laboratory developed a vestibular prosthesis...
  20. MOTOR CONTROL--TONIC NECK AND VESTIBULOSPINAL R EFLEXES
    VICTOR WILSON; Fiscal Year: 1992
    ..Some work on vestibulospinal reflexes will be done on cats with inactivated semicircular canals, to study pure otolith effects.
  21. VESTIBULOOCULAR RESPONSES TO LINEAR AND ANGULAR STIMULI
    DANIEL MERFELD; Fiscal Year: 2000
    ..the interaction of sensory cues from the otolith organs (measuring gravity and linear acceleration) and the semicircular canals (measuring rotation) and to understand the influence of the regular (tonic) and irregular (phasic) ..
  22. OTOLITH & CANAL SIGNALS IN VESTIBULAR-NECK REFLEX SYSTEM
    James Baker; Fiscal Year: 2007
    ..The neuronal circuitry of vestibular reflexes receives vestibular input from the semicircular canals and otoliths, and coordinates muscle contractions throughout the body...
  23. PHARMACOLOGY OF VESTIBULAR NEUROTRANSMISSION
    Paul Guth; Fiscal Year: 2000
    ..will be recorded using voltage and current clamping of hair cells isolated from the saccule and the semicircular canals. In addition to recording techniques, in situ hybridization and immunocytochemistry will be used to ..
  24. PROCESSING OF INFORMATION BY THE VESTIBULOSPINAL SYSTEM
    ROBERT SCHOR; Fiscal Year: 1993
    ..Experiments are designed to study the interaction of the vestibular signals from the semicircular canals and the gravity-sensing otolith organs, the interaction between vestibular and other sensory systems, and ..
  25. Biomechanics of the Semicircular Canals
    Richard Rabbitt; Fiscal Year: 2004
    ..The experimental model will be the oyster toadfish, Opsanus tau. The fundamental structure of the semicircular canals is ancient and shows remarkable similarity across vertebrates ranging from fish to man...
  26. Tbx1 Functions in Ear Development
    Antonio Baldini; Fiscal Year: 2007
    ..the requirement of Tbxl for the growth of the otocyst and for the formation of the cochlear duct and semicircular canals. Because of the fundamental importance of the affected developmental processes, we propose a genetic ..
  27. VESTIBULAR LABYRINTH IN HEALTH AND DISEASE
    STEPHEN HIGHSTEIN; Fiscal Year: 2000
    ..be the occurrence of benign paroxsismal positional vertigo thought due to gravitational responses of the semicircular canals when otolithnic particles break off and become lodged upon the cupula...
  28. VESTIBULOOCULAR FUNCTION IN NEUROOTOLOGICAL DISORDERS
    Joseph Furman; Fiscal Year: 1992
    ..Current vestibular laboratory testing evaluates only the semicircular canals while the otolith organs are not evaluated...
  29. Retinoic acid and regulation of BMP4 in development
    RONALD KOENIG; Fiscal Year: 2007
    ..Antagonism of BMP4 inhibits development of the semicircular canals. Embryonic exposure to exogenous RA results in a similar phenotype, suggesting that PA may repress BMP4 in ..
  30. Functional Organization of Extraocular Motoneurons
    Michael Jones; Fiscal Year: 2006
    ..by the sponsor's laboratory consisting of the isolated turtle brainstem with attached eyes and semicircular canals. This preparation provides the stability and control necessary for whole cell patch recording, yet permits ..
  31. Vestibular Contributions to Head Direction Cells
    Joel Brown; Fiscal Year: 2007
    ..Specific Aim 1 tests the hypothesis that horizontal semicircular canals in the chinchilla are necessary for normal HD cell activity...
  32. FUNCTION AND PLACTICITY IN CANAL OTOLITH INTERACTIONS
    GARY PAIGE; Fiscal Year: 2002
    ..VOR) is a set of reflexes activated by two forms of head acceleration; angular (the AVOR) driven by the semicircular canals, an linear (the LVOR) driven by the otoliths...
  33. INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
    Ruediger Thalmann; Fiscal Year: 1991
    ..to clinically relevant studies of the adaptive response to interferences with fluid dynamics of the semicircular canals. Project #1 involves the use of a novel tracer technique to measure directly the flow and volume of ..
  34. NEURAL MECHANISMS OF VESTIBULAR FUNCTION
    STEPHEN HIGHSTEIN; Fiscal Year: 2003
    ..Afferent nerve responses will be further evaluated in plugged semicircular canals. The ultrastructural organization and synaptology of functionally-characterized, biocytin-injected primary ..
  35. Head-mounted Positional Management System
    John Epley; Fiscal Year: 2003
    ..analysis and monitoring system to display graphically the ongoing spatial orientation of the subject's semicircular canals and indicate which semicircular canal is creating the nystagmus...
  36. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..these experiments will investigate the on-line interaction between rotational cues derived from the semicircular canals and gravito-inertial cues transduced by the otolith organs...
  37. Micro-Electric Impedance Spectroscopy of Hair Cells
    Richard Rabbitt; Fiscal Year: 2009
    ..Dr. Rabbitt, Professor of Bioengineering at the University of Utah, will direct the BRP team. ..
  38. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..3. Study how the nervous system combines sensory information from the otolith organs and semicircular canals when the rotational cues are provided via electrical stimulation. 4...
  39. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  40. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..
  41. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..measures of subjective visual vertical and horizontal provide physiologic measures of the function of the semicircular canals and utricle...
  42. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  43. VOR adaptation/utility of saccades as rehab strategies
    Michael Schubert; Fiscal Year: 2008
    ..This is important for the long-term goals of this project, which are to determine the adaptive preferences that individuals with vestibular loss use to improve gaze stability. ..
  44. Chemoanatomic bases for peripheral vestibular function
    GAY HOLSTEIN; Fiscal Year: 2007
    ..The proposed research is unique, and will have direct bearing on the development of more effective therapeutic interventions, both medicinal and device-oriented, for peripheral vestibular disorders. [unreadable] [unreadable] [unreadable]..
  45. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
  46. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  47. MORPHOLOGIC BASIS FOR CENTRAL VESTIBULAR INHIBITION
    GAY HOLSTEIN; Fiscal Year: 2002
    ....
  48. Function of Vestibular-Nerve Afferent Types
    Timothy Hullar; Fiscal Year: 2008
    ..Findings from this study will allow better understanding of pathologies of the peripheral vestibular system. ..
  49. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  50. Multilevel Dynamics of Conditional Control Mechanisms
    Gin McCollum; Fiscal Year: 2006
    ....
  51. NEURAL DECODING OF GRAVITO-INERTIAL CUES
    LIONEL ZUPAN; Fiscal Year: 2002
    ..this research is to better understand interactions of sensory cues from the vestibular system includes the semicircular canals and the otolith organs...
  52. VESTIBULO-OCULAR FUNCTION IN THE ELDERLY
    Joseph Furman; Fiscal Year: 2009
    ..Vestibular stimulation will activate both the semicircular canals and otolith organs...
  53. OCULOMOTOR SYSTEM AND BODY POSTURAL MECHANISMS
    Bernard Cohen; Fiscal Year: 2009
    ..components of the vestibulo-ocular and vestibular-cervical reflexes arising in the otolith organs and semicircular canals that are used to stabilize posture and gaze during natural quadrupedal and bipedal locomotion will be ..
  54. TREATMENTS FOR BENIGN PAROXYSMAL POSITIONAL VERTIGO
    Helen Cohen; Fiscal Year: 2008
    ..4. Determine the influence of rhinosinusitis. A) Determine the prevalence of rhinosinusitis in patients with BPPV. B) Determine if the presence of rhinosinusitis affects severity of symptoms or response to treatment. ..
  55. Galvanic Effects on the Human Vestibuloocular Reflex
    Americo Migliaccio; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  56. MANAGEMENT OF ADAPTATION TO ALTERED SENSORIMOTOR STATES
    Helen Cohen; Fiscal Year: 2003
    ..abstract_text> ..
  57. CERVICAL INFLUENCES ON BALANCE
    Joseph Furman; Fiscal Year: 2003
    ..To address specific aim #3, postural sway will be measured in response to naso-occipital optic flow within a virtual reality environment during several yaw head-on-trunk positions. ..
  58. QUANTITATIVE MORPHOPHYSIOLOGY OF VESTIBULAR AFFERENTS
    GOLDA KEVETTER; Fiscal Year: 2004
    ..This could prove important for treatment of patients with vestibular disorders, such as those suffering with Meniere's disease or even normal aging. ..
  59. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
  60. Optimized Conditioned Processing for Cochlear Implants
    Jay T Rubinstein; Fiscal Year: 2010
    ..In unilateral implantees, this work has already demonstrated substantial benefit in a limited number of subjects;it is our goal to deliver these benefits to the broader population of implant recipients. ..
  61. Signal processing in the vestibular nuclei
    Michael Rowe; Fiscal Year: 2003
    ....
  62. HEAD CONTROL MECHANISMS DURING VOLUNTARY TRUNK MOVEMENTS
    Timothy Hain; Fiscal Year: 2002
    ..The comparison of intact and BVL populations will elucidate why some persons with BVL recover relatively high functional levels, and others do not. ..