round window

Summary

Summary: Fenestra of the cochlea; an opening in the medial wall of the middle ear leading into the cochlea.

Top Publications

  1. ncbi Hair cell regeneration after local application of gentamicin at the round window of the cochlea in the pigeon
    M Muller
    Klinikum der J W Goethe Universitat, Physiologisches Institut III, Frankfurt am Main, Germany
    Hear Res 120:25-36. 1998
  2. ncbi Loud sound-induced changes in cochlear mechanics
    Anders Fridberger
    Karolinska Institutet, Department of Physiology and Pharmacology, SE 171 77 Stockholm, Sweden
    J Neurophysiol 88:2341-8. 2002
  3. ncbi Factors influencing the efficacy of round window dexamethasone protection of residual hearing post-cochlear implant surgery
    Andrew Chang
    University of Melbourne, Department of Otolaryngology, Royal Victorian Eye and Ear Hospital, Victoria, Australia
    Hear Res 255:67-72. 2009
  4. ncbi Treatment of mixed hearing losses via implantation of a vibratory transducer on the round window
    Vittorio Colletti
    ENT Department, University of Verona, Verona, Italy
    Int J Audiol 45:600-8. 2006
  5. ncbi Comparison of round window and cochleostomy approaches with a prototype hearing preservation electrode
    Robert J S Briggs
    Department of Otolaryngology, University of Melbourne, Melbourne, Australia
    Audiol Neurootol 11:42-8. 2006
  6. ncbi [Effects of round window membrane rupture on cochlear blood flow and endocochlear potential]
    Xiuli Liu
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya
    Nihon Jibiinkoka Gakkai Kaiho 106:723-9. 2003
  7. ncbi Influence of pH on the ototoxicity of cisplatin: a round window application study
    Fujinobu Tanaka
    Department of Surgery, Southern Illinois University School of Medicine, PO Box 19638, Springfield, IL 62794 9638, USA
    Hear Res 177:21-31. 2003
  8. pmc Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures
    Peter M M C Li
    Department of Otology and Laryngology, Harvard Medical School Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 28:641-8. 2007
  9. pmc Basilar membrane vibrations near the round window of the gerbil cochlea
    Edward H Overstreet
    Institute for Neuroscience and Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston IL 60208 3550, USA
    J Assoc Res Otolaryngol 3:351-61. 2002
  10. ncbi Effect of round window membrane application of nitric oxide on hearing and nitric oxide concentration in perilymph
    Jonathan B Hanson
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, Loma Linda University School of Medicine, Jerry L Pettis Memorial Veterans Medical Center, Loma Linda, CA 92354, USA
    Int J Pediatr Otorhinolaryngol 67:585-90. 2003

Research Grants

Detail Information

Publications218 found, 100 shown here

  1. ncbi Hair cell regeneration after local application of gentamicin at the round window of the cochlea in the pigeon
    M Muller
    Klinikum der J W Goethe Universitat, Physiologisches Institut III, Frankfurt am Main, Germany
    Hear Res 120:25-36. 1998
    ..Collagen sponges loaded with gentamicin were placed at the round window of the cochlea in adult pigeons...
  2. ncbi Loud sound-induced changes in cochlear mechanics
    Anders Fridberger
    Karolinska Institutet, Department of Physiology and Pharmacology, SE 171 77 Stockholm, Sweden
    J Neurophysiol 88:2341-8. 2002
    ....
  3. ncbi Factors influencing the efficacy of round window dexamethasone protection of residual hearing post-cochlear implant surgery
    Andrew Chang
    University of Melbourne, Department of Otolaryngology, Royal Victorian Eye and Ear Hospital, Victoria, Australia
    Hear Res 255:67-72. 2009
    To protect hearing in an experimental model of cochlear implantation by the application of dexamethasone to the round window prior to surgery...
  4. ncbi Treatment of mixed hearing losses via implantation of a vibratory transducer on the round window
    Vittorio Colletti
    ENT Department, University of Verona, Verona, Italy
    Int J Audiol 45:600-8. 2006
    ..Seven patients with severe mixed hearing loss were implanted with the transducer placed onto the round window. All had undergone previous surgery: six had multiple ossiculoplasties, and one had the VSB crimped on the ..
  5. ncbi Comparison of round window and cochleostomy approaches with a prototype hearing preservation electrode
    Robert J S Briggs
    Department of Otolaryngology, University of Melbourne, Melbourne, Australia
    Audiol Neurootol 11:42-8. 2006
    ..The electrode array is suitable for insertion via the round window membrane (RWM) or a small cochleostomy.
  6. ncbi [Effects of round window membrane rupture on cochlear blood flow and endocochlear potential]
    Xiuli Liu
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya
    Nihon Jibiinkoka Gakkai Kaiho 106:723-9. 2003
    ..To determine the effect of perilymphatic fistula on cochlear function, we studied the effect of round window membrane rupture on cochlear blood flow (CBF) by placing a laser-Doppler probe to the basal turn in 20 guinea ..
  7. ncbi Influence of pH on the ototoxicity of cisplatin: a round window application study
    Fujinobu Tanaka
    Department of Surgery, Southern Illinois University School of Medicine, PO Box 19638, Springfield, IL 62794 9638, USA
    Hear Res 177:21-31. 2003
    ..5), neutral (pH=7.4) or alkaline (pH=10.2) phosphate-buffered saline (PBS) was applied to the round window membrane...
  8. pmc Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures
    Peter M M C Li
    Department of Otology and Laryngology, Harvard Medical School Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 28:641-8. 2007
    ..The goal of this study was to create a three-dimensional model of the anatomy of the hook region to identify the optimal site for cochleostomy in cochlear implant surgery...
  9. pmc Basilar membrane vibrations near the round window of the gerbil cochlea
    Edward H Overstreet
    Institute for Neuroscience and Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston IL 60208 3550, USA
    J Assoc Res Otolaryngol 3:351-61. 2002
    ..In conclusion, basilar membrane responses near the round window of the gerbil cochlea closely resemble those for other basal cochlear sites in gerbil and other species.
  10. ncbi Effect of round window membrane application of nitric oxide on hearing and nitric oxide concentration in perilymph
    Jonathan B Hanson
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, Loma Linda University School of Medicine, Jerry L Pettis Memorial Veterans Medical Center, Loma Linda, CA 92354, USA
    Int J Pediatr Otorhinolaryngol 67:585-90. 2003
    ..We placed S-nitroso-N-acetylpenicillamine (SNAP), a NO donor compound, on the round window membrane (RWM) of adult chinchillas...
  11. ncbi Adenoviral vector gene delivery via the round window membrane in guinea pigs
    Mitsuya Suzuki
    Department of Otolaryngology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
    Neuroreport 14:1951-5. 2003
    ..containing phenol permitted beta-galactosidase (beta-gal) gene delivery to the guinea pig inner ear via the round window membrane (RWM). RWM damage was evident as degeneration of the outer epithelium...
  12. ncbi Round window application of D-methionine, sodium thiosulfate, brain-derived neurotrophic factor, and fibroblast growth factor-2 in cisplatin-induced ototoxicity
    Christoph Wimmer
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich, Germany
    Otol Neurotol 25:33-40. 2004
    In this study we tested the effect of local administration of D-methionine, sodium thiosulfate, brain-derived neurotrophic factor, and fibroblast growth factor-2 on cisplatin ototoxicity in guinea pigs to the round window membrane.
  13. pmc Ouabain application to the round window of the gerbil cochlea: a model of auditory neuropathy and apoptosis
    R A Schmiedt
    Department of Otolaryngology and Head Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    J Assoc Res Otolaryngol 3:223-33. 2002
    ..Because of the constant spike activity of these cells, the ouabain rapidly alters potassium concentrations within ([K+]i) and external to ([K+]o) the ganglion cells, thereby initiating an apoptotic cascade...
  14. ncbi Round window application of D-methionine provides complete cisplatin otoprotection
    Kurtis D Korver
    Division of Otolaryngology, Southern Illinois University, Springfield, USA
    Otolaryngol Head Neck Surg 126:683-9. 2002
    Cisplatin is a widely used, very effective chemotherapeutic agent that can cause severe ototoxicity. In this study, D-methionine was tested as an otoprotectant via round window membrane (RWM) application in the chinchilla.
  15. ncbi Round window membrane and labyrinthine pathological changes: an overview
    Sebahattin Cureoglu
    Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
    Acta Otolaryngol 125:9-15. 2005
    The round window membrane is considered the most likely pathway from the middle to the inner ear. Various substances placed in the middle ear have been seen to pass through the round window membrane...
  16. ncbi Preservation of low frequency hearing in partial deafness cochlear implantation (PDCI) using the round window surgical approach
    Henryk Skarzynski
    Institute of Physiology and Pathology of Hearing, Warsaw, Poland
    Acta Otolaryngol 127:41-8. 2007
    Successful hearing preservation is possible in individuals with excellent low frequency hearing. This is possible due to the partial insertion of an atraumatic electrode using an atraumatic round window surgical technique.
  17. ncbi The relationship of the round window membrane to the cochlear aqueduct shown in three-dimensional imaging
    R Hofman
    Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands
    Hear Res 209:19-23. 2005
    The round window membrane and cochlear aqueduct complex in the guinea pig are reconstructed with 3D-imaging, using orthogonal plane fluorescence optical sectioning (OPFOS)...
  18. pmc Cochlear aqueduct flow resistance depends on round window membrane position in guinea pigs
    R A Feijen
    Department of Otorhinolaryngology, University Hospital Groningen, Groningen, The Netherlands
    J Assoc Res Otolaryngol 5:404-10. 2004
    ..The resistance for fluid flow of the cochlear aqueduct was measured in guinea pigs for different positions of the round window membrane...
  19. ncbi Analysis of gentamicin kinetics in fluids of the inner ear with round window administration
    Stefan K R Plontke
    Tübingen Hearing Research Center, University of Tubingen, Germany
    Otol Neurotol 23:967-74. 2002
    ..That a theoretical basis for quantifying drug distribution in the inner ear with local applications can be established...
  20. ncbi [Use of the round window micro cath for inner ear therapy - results of a placebo-controlled, prospective study on chronic tinnitus]
    B Schwab
    HNO Klinik der Medizinischen Hochschule Hannover
    Laryngorhinootologie 83:164-72. 2004
    ..Problems relating to dosage, systemic effects and the blood-cochlear barrier are thus avoided, which is not the case with systemic therapy. The preferred access point is the membrane of the round window.
  21. ncbi [The effects of Streptolysin-O and sodium hyaluronate on the permeability of the round window membrane in guinea pigs--an electrophysiologic study]
    O Selivanova
    Hals Nasen Ohrenklinik und Poliklinik der Johannes Gutenberg Universität Mainz
    Laryngorhinootologie 82:235-9. 2003
    The round window membrane (RWM) acts like a barrier for topically applied substances into the middle ear preventing diffusion into the perilymphatic fluid compartment.
  22. ncbi Round window stimulation with an implantable hearing aid (Soundbridge) combined with autogenous reconstruction of the auricle - a new approach
    Jan Kiefer
    Department of Otolaryngology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    ORL J Otorhinolaryngol Relat Spec 68:378-85. 2006
    ..This report describes a new approach, combining the reconstruction of the auricle with implantation of an active middle ear hearing aid, stimulating the round window membrane.
  23. pmc Role of mannitol in reducing postischemic changes in distortion-product otoacoustic emissions (DPOAEs): a rabbit model
    Krzysztof Morawski
    Ear, Nose, and Throat Department, Silesian Medical Academy, Zabrze, Poland
    Laryngoscope 113:1615-22. 2003
    The aim of this study was to observe the effects of mannitol, administered topically at the round window (RW), on cochlear blood flow (CBF) and distortion-product otoacoustic emission (DPOAE) after repeated episodes of cochlear ischemia.
  24. ncbi Quantitative interpretation of corticosteroid pharmacokinetics in inner fluids using computer simulations
    Stefan K R Plontke
    Tubingen Hearing Research Center and Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, D 72076 Tubingen, Germany
    Hear Res 182:34-42. 2003
    The delivery of drugs to the inner ear by applying them directly onto the round window membrane is a promising way to treat human inner ear disorders...
  25. pmc Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Audiol Neurootol 12:37-48. 2007
    ..Cochlear fluid pharmacokinetics can be better represented by three-dimensional (3D) finite-element simulations of drug dispersal...
  26. ncbi Protective effect of brain-derived neurotrophic factor against the ototoxicity of Pseudomonas aeruginosa exotoxin A
    Manabu Maeta
    Department of Otorhinolaryngology and Head and Neck Surgery, Uppsala University Hospital, Uppsala, Sweden
    Acta Otolaryngol 123:14-9. 2003
    ..The combined effect of BDNF and N(G)-nitro-L-arginine methyl ester (L-NAME) was also investigated...
  27. ncbi Acute treatment of noise trauma with local caroverine application in the guinea pig
    Zhiqiang Chen
    Department of Otolaryngology, National University of Singapore, Singapore
    Acta Otolaryngol 123:905-9. 2003
    ..3 kHz (110 dB sound pressure limit) for 1 h. One or 24 h after noise exposure, caroverine was applied to the round window membrane. Auditory brainstem responses were recorded at regular time intervals...
  28. ncbi Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals
    Jing Wang
    INSERM U 583, 80 rue Augustin Fliche, 34295 Montpellier, France
    Mol Pharmacol 71:654-66. 2007
    We tested and characterized the therapeutic value of round window membrane-delivered (RWM) d-JNKI-1 peptide (Bonny et al., 2001) against sound trauma-induced hearing loss...
  29. ncbi Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide?
    Chung Ku Rhee
    Department of Otolaryngology Head and Neck Surgery, Medical Laser Research Center, College of Medicine, Dankook University, Anseo Dong, Cheonan City, Chungnam Do, Korea 330 714
    Laryngoscope 113:2059-66. 2003
    ..purpose of this study is to investigate the role of nitric oxide (NO) in the mechanism of PAF-induced hearing loss by studying the effects of PAF application on the round window membrane (RWM) with and without PAF-antagonist NO-blocker.
  30. ncbi Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid
    Alec N Salt
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 182:24-33. 2003
    ..TMPA solution was irrigated across the round window membrane while a TMPA-selective electrode sealed into the perilymphatic space continuously monitored perilymph ..
  31. pmc A frequency-position function for the human cochlear spiral ganglion
    Divya Sridhar
    Epstein Laboratory, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, California 94143 0526, USA
    Audiol Neurootol 11:16-20. 2006
    ....
  32. ncbi Fluid volume displacement at the oval and round windows with air and bone conduction stimulation
    Stefan Stenfelt
    Division of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, Stanford, California, USA
    J Acoust Soc Am 115:797-812. 2004
    ..are normally considered incompressible, and the fluid volume displacement of the oval window (OW) and the round window (RW) should be equal and of opposite phase...
  33. ncbi Direct measurement flow resistance of cochlear aqueduct in guinea pigs
    Elisabeth O Laurens-Thalen
    Department of Otorhinolaryngology, University Hospital Groningen, Groningen, The Netherlands
    Acta Otolaryngol 124:670-4. 2004
    ..In this study the flow resistance of the cochlear aqueduct was determined and its relation with inner ear pressure was studied...
  34. ncbi Cochlear transducer operating point adaptation
    Yuan Zou
    Oregon Hearing Research Center, NRC04, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239 3098, USA
    J Acoust Soc Am 119:2232-41. 2006
    ..Removing the force induced recovery of the second harmonic to its normal level described by a single time constant. The force applied over the SV caused an opposite result. These data indicate an active mechanism for OHC transduction OP...
  35. ncbi Response of cochlear blood flow to prostaglandin E1 applied topically to the round window
    Mitsuo Tominaga
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Acta Otolaryngol 126:232-6. 2006
    The increase in cochlear blood flow (CBF) after administration of prostaglandin E1 (PGE1) to the round window depends on increased blood flow through the anterior inferior cerebellar artery (AICA).
  36. ncbi Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: an experimental study in guinea pigs
    Wolfgang Arnold
    Clinic for Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, DE 81675 Munich, Germany
    Audiol Neurootol 10:53-63. 2005
    ..Therefore, the placebo implants, the slow-release and the fast-release beclomethasone implants appear suitable for further experiments...
  37. ncbi Preservation of basal inner ear structures in cochlear implantation
    Oliver Adunka
    ENT Department, J W Goethe University, Frankfurt am Main, Germany
    ORL J Otorhinolaryngol Relat Spec 66:306-12. 2004
    ..cochlear implant electrode arrays manufactured by MED-EL using either a caudal approach cochleostomy or round window membrane insertions...
  38. ncbi Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss
    Brian D Herr
    Department of Otolaryngology Head and Neck Surgery, Loyola University Medical Center, IL 60153, USA
    Otolaryngol Head Neck Surg 132:527-31. 2005
    ..Furthermore, not all patients will benefit from steroid administration. This study evaluates the potential benefits and safety of treating patients with SSHL refractory to oral steroids with intratympanic steroid therapy...
  39. ncbi Cochlear hair cell loss in single-dose versus continuous round window administration of gentamicin
    Niels Wagner
    Department of Otorhinolaryngology, Gentofte University Hospital of Copenhagen, Hellerup, Denmark
    Acta Otolaryngol 125:340-5. 2005
    ..Gentamicin-induced cochlear hair cell loss depends on local middle ear administration kinetics and the total drug dose. Single-dose gentamicin instillation in the middle ear is associated with a high variation in hair cell loss...
  40. ncbi [Pharmacokinetics of the methylprednisolone, dexamethasone and hydrocortisone in the inner ear after administered via round window]
    Sui Li
    Department of Otolaryngology, Union Hospital, Wuhan, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:24-6. 2005
    To compare the pharmacokinetics of Methylprednisolone, Dexamethasone and Hydrocortisone in the inner era of guinea pig after administered via round window.
  41. ncbi A deafness mutation isolates a second role for the tectorial membrane in hearing
    P Kevin Legan
    School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Nat Neurosci 8:1035-42. 2005
    ..Thus, using Tecta(Y1870C/+) mice, we have genetically isolated a second major role for the tectorial membrane in hearing: it enables the motion of the basilar membrane to optimally drive the inner hair cells at their best frequency...
  42. ncbi The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption
    Avik Banerjee
    Department of Otolaryngology, University of Western Ontario, London Health Sciences Centre, 339 Windermere Road, London, Ontario, N6A 5A5, Canada
    Otolaryngol Clin North Am 37:1035-51. 2004
    The application of therapeutic agents to the round window holds great promise in the treatment of inner ear disease...
  43. ncbi Intratympanic perfusion for the treatment of tinnitus
    Kelley M Dodson
    Department of Otolaryngology Head and Neck Surgery, Virginia Commonwealth University Medical Center, 1201 East Marshall Street, Suite 402 Richmond, VA 23298, USA
    Otolaryngol Clin North Am 37:991-1000. 2004
    ..6. Further prospective, randomized, and controlled studies to evaluate the effect of intratympanic perfusion for the treatment of tinnitus are warranted...
  44. ncbi [The effects of DPPH on cochlear microcirculation]
    Min Chen
    Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 18:167-8. 2004
    ..To investigate the effects of free radical, 1, 1-Diphenyl-2-picylhydrazyl(DPPH), on cochlear blood flow...
  45. ncbi K(+) currents produce P(1) in the RW CAP: evidence from DC current bias, K(+) channel blockade and recordings from cochlea and brainstem
    D J Brown
    The Auditory Laboratory, Discipline of Physiology, M311, The University of Western Australia, Crawley, WA 6009, Australia
    Hear Res 190:60-74. 2004
    Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW...
  46. ncbi Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss
    F van Wijk
    Department of Otorhinolaryngology, University of Liege, Liege, Belgium
    Audiol Neurootol 11:357-65. 2006
    ..To evaluate the effect of transtympanic administration of tumor necrosis factor alpha (TNF-alpha) blockers to patients suffering from autoimmune inner ear disease (AIED)...
  47. ncbi Determinants of the spectrum of the neural electrical activity at the round window: transmitter release and neural depolarisation
    R B Patuzzi
    The Auditory Laboratory, Department of Physiology, M311, University of Western Australia, Crawley, WA 6009, Australia
    Hear Res 190:87-108. 2004
    In this paper we summarise the changes we have observed in the electrical activity at the round window (RW) of guinea pigs during transient cooling of the RW or cochlear nucleus (CN), transient hypoxia, low frequency acoustic biasing, ..
  48. ncbi Inner ear therapy for neural preservation
    Rachael T Richardson
    The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia
    Audiol Neurootol 11:343-56. 2006
    ..Duration of treatment, drug diffusion, effectiveness and safety are discussed with references to how they may be translated to the implementation of neurotrophic factor treatment for neural preservation...
  49. pmc Gentamicin pharmacokinetics in the chicken inner ear
    Eric C Bunting
    Kansas Ear Nose Throat, Wichita, KS 67211, USA
    J Assoc Res Otolaryngol 5:144-52. 2004
    ..A recent method utilizes topical application of an ototoxic drug to the round window membrane...
  50. ncbi Localization of endotoxin in the inner ear following inoculation into the middle ear
    Masaya Takumida
    Hiroshima University School of Medicine, Hiroshima, Japan
    Acta Otolaryngol 124:772-7. 2004
    ..such hearing loss in OM is thought to be due to transmission of toxins and other bacterial products through the round window membrane, damaging the hair cells of the basal turn of the cochlea...
  51. ncbi Cochlear implantation via the round window membrane minimizes trauma to cochlear structures: a histologically controlled insertion study
    Oliver Adunka
    ENT Department, J W Goethe University, Frankfurt am Main, Germany
    Acta Otolaryngol 124:807-12. 2004
    To evaluate cochlear implant trauma to intracochlear structures when inserting the electrode via the round window membrane.
  52. ncbi Intratympanic treatment of hearing loss with novel and traditional agents
    Michael D Seidman
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Medical Center, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Otolaryngol Clin North Am 37:973-90. 2004
    ..Because most of the studies conducted to date have been animal studies, randomized, double-blind, placebo-controlled clinical trials would be necessary before the use of these therapies becomes common practice...
  53. ncbi [Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations]
    Dongming Hou
    Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Second Medical University, Shanghai, 200092, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:307-10. 2005
    ..To determine pharmacokinetics profiles of dexamethasone (DEX) in perilymph of guinea pig with different intratympanic administrations, and to provide experimental evidence for clinical choice about administration...
  54. ncbi Current issues in cochlear gene transfer
    Anil K Lalwani
    Epstein Laboratories, Department of Otolaryngology, Head and Neck Surgery, University of California, San Francisco, CA 94143 0526, USA
    Audiol Neurootol 7:146-51. 2002
    ..the cochlea and application of vector-transgene complex-soaked Gelfoam((R)) into the direct contact with the round window membrane...
  55. ncbi Safety of ofloxacin (OFLX) and fosfomycin sodium (FOM) ear drops
    T Yamano
    Department of Otolaryngology, Fukuoka University Nanakuma, Jonan ku, Fukuoka City, Japan
    Int J Pediatr Otorhinolaryngol 71:979-83. 2007
    ..The objective of this study is to evaluate the safety of two ear drops, Ofloxacin (OFLX: Taribid Otic Solution, Daiichi Seiyaku) and Fosfomycin sodium (FOM: Fosmicin S, Meiji Seiyaku)...
  56. ncbi Transtympanic endoscopy for drug delivery to the inner ear using a new microendoscope
    Stefan K R Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Germany
    Adv Otorhinolaryngol 59:149-55. 2002
    Anatomic variations of the round window (RW) niche found in approximately 33% of human temporal bones may account for some ofthe problems associated with local drug delivery to the inner car...
  57. ncbi Multifrequency immittancemetry in experimentally induced stapes, round window and cochlear lesions
    Vincent Darrouzet
    Otolaryngology and Skull Base Surgery Department, University of Bordeaux 2 Victor Segalen, Bordeaux, France
    Audiol Neurootol 12:85-100. 2007
    ..To establish that admittance (Y) and susceptance (B) conductance (G) tympanograms at 2 kHz can reflect the status of the annular ligament and the cochlear pressure...
  58. ncbi Cochlear aqueduct flow resistance is not constant during evoked inner ear pressure change in the guinea pig
    Hero P Wit
    Department of Otorhinolaryngology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Hear Res 175:190-9. 2003
    ..After a positive-going middle ear pressure change the calculated flow resistance changed with round window position and with the pressure difference across the cochlear aqueduct...
  59. ncbi Quinine affects the response properties of compound action potentials elicited by periodic click trains
    Kentaro Ochi
    Department of Otolaryngology, St Marianna University School of Medicine, Kawasaki City, Japan
    Ann Otol Rhinol Laryngol 111:423-9. 2002
    ..200 mg/kg body weight of quinine hydrochloride was administered intramuscularly, and CAPs were recorded at the round window before and after administration...
  60. ncbi Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs
    Zhiqiang Chen
    Department of Otolaryngology, National University of Singapore, Singapore
    Audiol Neurootol 8:49-56. 2003
    ..Local administration of caroverine on the round window membrane (RWM) could be a more effective means of administration to avoid systemic side/adverse effects...
  61. ncbi Change of guinea pig inner ear pressure by square wave middle ear cavity pressure variation
    R A Feijen
    Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands
    Acta Otolaryngol 122:138-45. 2002
    ..A possible explanation for the large difference in time constants for positive or negative middle ear pressure changes is a dependence on aqueduct flow resistance or round window membrane position.
  62. ncbi Effects of furosemide applied chronically to the round window: a model of metabolic presbyacusis
    Richard A Schmiedt
    Department of Otolaryngology and Head Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 22:9643-50. 2002
    ..This model suggests that the primary factor in true age-related hearing loss is an energy-starved cochlear amplifier that results in a specific audiogram profile...
  63. ncbi Clinical, experimental, and theoretical investigations of the effect of superior semicircular canal dehiscence on hearing mechanisms
    John J Rosowski
    Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:323-32. 2004
    ..input impedance, 2) shunts air-conducted sound away from the cochlea resulting in conductive hearing loss, and 3) improves bone-conduction thresholds by increasing the difference in impedance between the vestibule and the round window.
  64. ncbi Magnetic resonance imaging of the inner ear in Meniere's disease
    Ilmari Pyykko
    Department of Otolaryngology, University of Tampere, Teiskontie 35, 33520, Tampere, Finland
    Otolaryngol Clin North Am 43:1059-80. 2010
    ..In healthy animals the scala media did not load GdC. In mice in which GdC was administered topically onto the round window, loading of the cochlea peaked at 4 hours, at which time it reached the apex...
  65. ncbi Active middle ear implants in patients undergoing subtotal petrosectomy: new application for the Vibrant Soundbridge device and its implication for lateral cranium base surgery
    Thomas Linder
    Department of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital Luzern, Luzern, Switzerland
    Otol Neurotol 30:41-7. 2009
    ..The direct placement of a vibrating floating mass transducer (FMT) onto the round window membrane with obliteration of the surgical cavity is a new option.
  66. ncbi Ototoxicity of sodium nitroprusside
    R S Ruan
    Department of Otolaryngology, National University Hospital, Singapore
    Hear Res 114:169-78. 1997
    ..A piece of gelfoam was placed on the round window of the right ear of adult albino guinea pigs. It was then soaked with 0.1 ml of SNP (3.4 microM), 0...
  67. ncbi Middle ear application of a sodium hyaluronate gel loaded with neomycin in a Guinea pig model
    Amanj Saber
    Department of Clinical Neuroscience, Center for Hearing and Communication Research, Karolinska Institutet, Stockholm, Sweden
    Ear Hear 30:81-9. 2009
    ..To evaluate the efficacy of sodium hyaluronate (HYA) as a vehicle for drugs that could be used for treatment of inner ear disorders...
  68. ncbi [Transmission of changes in the external ear atmospheric pressure to the perilymph]
    S Nishihara
    Department of Otolaryngology, Ehime University School of Medicine
    Nihon Jibiinkoka Gakkai Kaiho 93:707-15. 1990
    ..to the perilymph was significantly impaired either by disrupting the ossicular chain or by closing the round window niche, especially by the latter...
  69. ncbi Modeling of sound transmission from ear canal to cochlea
    Rong Z Gan
    School of Aerospace and Mechanical Engineering and Bioengineering Center, University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK 73019, USA
    Ann Biomed Eng 35:2180-95. 2007
    ..The middle ear transfer function such as the movements of tympanic membrane, stapes footplate, and round window, the sound pressure gain across the middle ear, and the cochlear input impedance in response to sound stimulus ..
  70. ncbi Non-syndromal round window atresia: an autosomal dominant genetic disorder with variable penetrance?
    A Borrmann
    Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Eur Arch Otorhinolaryngol 264:1103-8. 2007
    b>Round window atresia can be seen in association with syndromal anomalies such as mandibulofacial dysostosis, Mondini type anomalies or cretinism, or with extensive otosclerosis...
  71. ncbi Directional hearing in the barn owl (Tyto alba)
    R B Coles
    Research School of Biological Sciences, Australian National University, Canberra
    J Comp Physiol A 163:117-33. 1988
    ..sensitivity of the barn owl ear was studied by recording cochlear microphonic (CM) potentials from the round window membrane...
  72. ncbi Cochlear implantation in healthy and otitis-prone children: a prospective study
    M Luntz
    Department of Otolaryngology Head and Neck Surgery, Bnai Zion Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Laryngoscope 111:1614-8. 2001
    ..To evaluate and compare the timing of surgery, intraoperative findings, and otitis media-related outcome of cochlear implantation in children who are otitis-prone with their counterparts who are not otitis-prone...
  73. ncbi [The effect of high-rate electrical stimulation on excitability of auditory nerve in Guinea pigs]
    Aiguo Liu
    Department of Otolaryngology, EENT Hospital of Fudan University, Shanghai, 200031, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:454-6, 460. 2005
    ..To assess the effect of high-rate electrical stimulation on excitability of the auditory nerve by recording the change of amplitude of the electrically evoked auditory brainstem responses (EABR)...
  74. ncbi Temporal bone investigations on landmarks for conventional or endosteal insertion of cochlear electrodes
    Hans W Pau
    ENT HNS Department, Medical School, University of Rostock, Rostock, Germany
    Acta Otolaryngol 127:920-6. 2007
    Our anatomical findings place special emphasis on the requirement to follow an infero-anterior approach to the round window, to expose the scala tympani safely for 'normal' cochlear implantation...
  75. ncbi Electrically evoked otoacoustic emissions from apical and basal perilymphatic electrode positions in the guinea pig cochlea
    A L Nuttall
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, NRC04, Portland, OR 97201 3098, USA
    Hear Res 152:77-89. 2001
    ..In this study we test the hypothesis that the wide frequency response from round window (RW) stimulation is due to the involvement of a relatively large spatial segment of the organ of Corti...
  76. ncbi Are inner or outer hair cells the source of summating potentials recorded from the round window?
    J D Durrant
    Department of Communication Science and Disorders, University of Pittsburgh, Pennsylvania 15260, USA
    J Acoust Soc Am 104:370-7. 1998
    ..To determine which type of hair cells is the dominant source of the SP recorded at the round window, we used carboplatin to selectively destroy IHCs or a combination of IHCs and OHCs in the chinchilla...
  77. pmc Evaluation of round window stimulation using the floating mass transducer by intracochlear sound pressure measurements in human temporal bones
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, Cambridge, Massachusetts, U S A
    Otol Neurotol 31:506-11. 2010
    b>Round window (RW) stimulation with a floating mass transducer (FMT) can be studied experimentally and optimized to enhance auditory transduction.
  78. ncbi Electrocochleographic and mechanical assessment of round window stimulation with an active middle ear prosthesis
    Kanthaiah Koka
    Department of Physiology and Biophysics, University of Colorado Denver, Aurora, CO 80045, USA
    Hear Res 263:128-37. 2010
    Mechanical stimulation of the round window (RW) with an active middle ear prosthesis (AMEP) has shown functional benefit in clinical reports in patients with mixed hearing loss (MHL)...
  79. pmc Organization of olivocochlear neurons in the cat studied with the retrograde tracer cholera toxin-B
    W Bruce Warr
    Boys Town National Research Hospital, Omaha, NE 68131, USA
    J Assoc Res Otolaryngol 3:457-78. 2002
    ..Adult cats received injections of CTB through the round window of the left cochlea, and, after 3-6 days, the brains were sectioned transversely and CTB was revealed ..
  80. ncbi Prevalence of histologic otosclerosis: an unbiased temporal bone study in Caucasians
    F Declau
    Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, University Hospital of Antwerp, Antwerp, Belgium
    Adv Otorhinolaryngol 65:6-16. 2007
    ..at a site where it causes conductive hearing loss by interfering with the motion of the stapes or of the round window membrane...
  81. pmc Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranes
    Susan E Voss
    Picker Engineering Program, Smith College, 51 College Lane, Northampton, Massachusetts 01063, USA
    J Acoust Soc Am 122:2135-53. 2007
    ..canal lateral to the TM, P(TM); (2) in the tympanic cavity lateral to the oval window, P(OW); and (3) near the round window, P(RW)...
  82. ncbi Protective effects of alpha-tocopherol against gentamicin-induced Oto-vestibulo toxicity: an experimental study
    Anna Rita Fetoni
    Institute of Otolaryngology, Catholic University of Rome, Rome, Italy
    Acta Otolaryngol 123:192-7. 2003
    ....
  83. ncbi Spectrum of neural electrical activity in guinea pig cochlea: effects of anaesthesia regimen, body temperature and ambient noise
    I Sendowski
    Centre de Recherches du Service de Santé des Armées CRSSA, Département de radiobiologie, 24 avenue des Maquis du Grésivaudan BP 87, 38702, La Tronche Cedex, France
    Hear Res 211:63-73. 2006
    Spectral analysis of electric noise recorded from the round window of the cochlea is thought to represent the summed spontaneous activity of the auditory nerve. It has been postulated that it could provide a possible tinnitus index...
  84. ncbi The effects of sound conditioning on gentamicin-induced vestibulocochlear toxicity in gerbils
    Amar C Suryadevara
    Department of Otolaryngology and Communication Sciences, SUNY Upstate Medical University, Syracuse, New York, USA
    Laryngoscope 119:1166-70. 2009
    ..The objective of this study is to determine whether sound conditioning provides protection against gentamicin in the cochlear and/or vestibular system...
  85. ncbi Does erythropoietin augment noise induced hearing loss?
    Birgitte Lidegaard Frederiksen
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Hear Res 223:129-37. 2007
    ..EPO was administered to the round window membrane 24h after noise exposure, either sustained by pump for a week or by single dose middle ear ..
  86. ncbi Preservation of residual hearing with cochlear implantation: how and why
    Chris James
    Service ORL, Hopital Purpan, FR 31059 Toulouse, France
    Acta Otolaryngol 125:481-91. 2005
    ..Residual hearing combined with electrical stimulation in the same ear can provide additional benefits even for conventional candidates for cochlear implantation...
  87. ncbi The mechanism and site of action of lidocaine hydrochloride in guinea pig inner ear
    E Laurikainen
    Department of Otolaryngology, Turku University Central Hospital, Finland
    Acta Otolaryngol 117:523-8. 1997
    Lidocaine was applied to the round window (RW) in order to localize its site of action in the cochlea...
  88. ncbi Partial deafness cochlear implantation in children
    Henryk Skarzynski
    Institute of Physiology and Pathology of Hearing, Warsaw, Poland
    Int J Pediatr Otorhinolaryngol 71:1407-13. 2007
    ..Good hearing preservation and speech perception outcomes have been reported. This study aims to assess partial deafness cochlear implantation in children...
  89. ncbi Jacobson's nerve clues to the round window niche
    N Wendell Todd
    Department of Otolaryngology, Emory University, Atlanta, Georgia 30322, USA
    Cochlear Implants Int 10:63-9. 2009
    The round window niche is used as a primary guide to cochleostomy for cochlear implantation, but sometimes the niche is not visible through the dissected facial recess. In such cases, Jacobson's nerve may be a guide to the niche...
  90. ncbi [Expression patterns of non-viral transfection with GFP in the organ of Corti in vitro and in vivo. Gene therapy of the inner ear with non-viral vectors]
    M Praetorius
    Sektion Otologie und Neuro Otologie, Hals, Nasen, Ohrenklinik mit Poliklinik, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg
    HNO 56:524-9. 2008
    ..Gene therapy might become a potential modality of treatment. Viral vectors are standard in animal models to date. Future considerations, however, call for a further evaluation of non-viral transfection methods...
  91. ncbi [Rupture of the round window--detection with fluorescence endoscopy]
    D Kleemann
    HNO Klinik der Müritz Klinikum GmbH, Weinbergstrasse 19, 17192 Waren Müritz
    HNO 49:89-92. 2001
    Rupture of the round window membrane as a special cause of inner ear deafness is widely accepted after changing pressure levels, e.g. in diving...
  92. pmc Change of middle ear transfer function in otitis media with effusion model of guinea pigs
    Chenkai Dai
    School of Aerospace and Mechanical Engineering and Bioengineering Center, University of Oklahoma, Norman, OK 73019, USA
    Hear Res 243:78-86. 2008
    ..Vibrations of the umbo and round window membrane were measured with a laser Doppler vibrometer at frequency range of 200-40 kHz in three groups of 3, 7,..
  93. ncbi Transcanal approach to the singular nerve
    Maria Izabel Kos
    Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospital, Geneva, Switzerland
    Otol Neurotol 27:542-6. 2006
    ....
  94. ncbi New insight into the bony labyrinth: a microcomputed tomography study
    C Richard
    ENT, Head and Neck Surgery Department, Hopital Nord, B1, CHU de Saint Etienne, Saint Etienne, France
    Auris Nasus Larynx 37:155-61. 2010
    ..To visualize and quantify the morphology and mineralization of the developing fetal human bony labyrinth, using 3D-microcomputed tomography (3D-microCT) imaging...
  95. pmc Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani
    Alec N Salt
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Neurosci Methods 153:121-9. 2006
    ..prior studies, ST perilymph samples have been obtained from the basal turn, either by aspiration through the round window membrane (RWM) or through an opening in the bony wall...
  96. ncbi Results of exploratory tympanotomy following sudden unilateral deafness and its effects on hearing restoration
    Wolfgang Maier
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Ludwigs University Medical School, Killianstr 5, D 79106 Freiburg, Germany
    Ear Nose Throat J 87:438-51. 2008
    In cases of acute unilateral deafness, no consensus exists as to whether tympanotomy and sealing of the round window should be performed routinely...
  97. ncbi European results with totally implantable carina placed on the round window: 2-year follow-up
    Christian Martin
    Service d Oto Rhino Laryngologie, CHU Saint Etienne, CHU Nord, Assistance Publique, Hôpitaux de Marseille and Université de La Méditerranée, Marseille, France
    Otol Neurotol 30:1196-203. 2009
    First, to assess for the performance of the Carina placed on the round window at various European centers; second, to study the follow-up after 2 years and discuss limitations and technical issues; and finally, to further develop our ..
  98. ncbi [Multi-channel cochlear implant in cochlear ossification]
    E Pasanisi
    Dipartimento di Scienze Otorino Odonto Oftalmologiche e Cervico Facciali, Sezione di Otorinolaringoiatria e Microchirurgia Otologica e Otoneurologica, Universita di Parma
    Acta Otorhinolaryngol Ital 22:127-34. 2002
    ..In 3 cases the ossification was limited to the region of the round window and a few millimetres of the scala tympani; cochleostomy was performed anteriorly and inferiorly to the ..
  99. ncbi Safety of ciprofloxacin and dexamethasone in the guinea pig middle ear
    Leslie E Lemke
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
    Arch Otolaryngol Head Neck Surg 135:575-80. 2009
    ..To investigate the ototoxic potential of ciprofloxacin hydrochloride, 0.3%, plus dexamethasone, 0.1%, after administration to the guinea pig middle ear...
  100. ncbi Intratympanic dexamethasone and hyaluronic acid in patients with low-frequency and Ménière's-associated sudden sensorineural hearing loss
    Oksana A Selivanova
    Department of Otolaryngology, Head and Neck Surgery, University of Mainz Medical School, Mainz, Germany
    Otol Neurotol 26:890-5. 2005
    ..Direct steroid application in the middle ear cavity, when combined with a round window membrane permeability-modulating substance, increases the level of the steroid reaching the target cells...
  101. ncbi Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane
    Jing Zou
    Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland
    Otol Neurotol 31:637-41. 2010
    To investigate the inner ear uptake of the contrast agent gadolinium administered intratympanically through transtympanic injection or using a gelatin sponge placed on the round window.

Research Grants37

  1. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..of transplatin against cisplatin-induced hearing loss, using either systemic administration or by direct round window application of transplatin...
  2. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard P Rybak; Fiscal Year: 2012
    ..aim 1, we will administer systemically the antioxidant lipoic acid or short-interfering RNAs (siRNAs) on the round window (RW) to block activation of NOX-3 by cisplatin...
  3. Effect of the Middle Ear Inflammation On the Inner Ear
    STEVEN SUNG KYUN JUHN; Fiscal Year: 2013
    ..Bacterial components and inflammatory mediators produced in the middle ear pass through the round window membrane into the inner ear, damage cochlear structures, resulting in hearing loss...
  4. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2013
    ..We will also integrate the polymer into a wafer for delivery via the round window membrane. The otic capsule is unique in that it normally exhibits little or no bone remodeling...
  5. Mechanics of Human Middle & Inner Ear: Basic Science &Clinical Application
    Hideko Heidi Nakajima; Fiscal Year: 2013
    ..The measurements of BC-evoked DP will elucidate BC mechanisms and improve applications of BC for diagnosis and treatment. ..
  6. Investigations of Human Auditory Mechanics
    Hideko Heidi Nakajima; Fiscal Year: 2012
    ..if a useful level of hearing is possible when the oval window is blocked and the cochlea is stimulated via the round window (RW)...
  7. Structure and Function Relations in Middle Ears
    John J Rosowski; Fiscal Year: 2012
    ..2) We investigate the contribution of the round window and natural or pathologic `third windows'to normal, pathological and aided middle-ear function...
  8. Precision Particle Fabrication-enabled Betamethasone-loaded Microspheres for Tran
    Milind Singh; Fiscal Year: 2012
    ..Precision Particle Fabrication (PPF) to create betamethasone-loaded microspheres for transtympanic injection, round window membrane (RWM) localization, and sustained-release to the inner ear...
  9. INNER EAR FLUID INTERACTIONS
    Alec N Salt; Fiscal Year: 2013
    ..difficulties in obtaining pure perilymph samples and the highly variable perilymph drug levels produced by round window applications...
  10. Backward and Forward Driven Eardrum Motions
    Jeffrey Tao Cheng; Fiscal Year: 2013
    ..measurements in the evaluation of active middle-ear prostheses that drive the intact ossicular chain or the round window. PUBLIC HEALTH RELEVANCE: Understanding how the eardrum responds to forward (normal) sound stimuli and reverse ..
  11. OTITIS MEDIA PATHOGENESIS RESEARCH PROGRAM
    G Giebink; Fiscal Year: 1991
    ..Also, otophysiologic studies with animals are underway and will continue to investigate round window membrane permeability changes. Effects of topical drugs (antibiotics and antibiotic vehicles) will be studied...
  12. SENSORINEURAL HEARING LOSS--PERILYMPHATIC FISTULAS
    Robert Kohut; Fiscal Year: 1999
    ..These specimens demonstrate LCP by way of the fissula ante fenestram and the fissure of the round window niche posterior canal ampulla supporting the central hypothesis of the studies of this grant...
  13. Potentiation--noise induced hearing loss--acrylonitrile
    Laurence Fechter; Fiscal Year: 2003
    ..along with assessment of auditory threshold via measurement of the compound action potential (CAP) from the round window. We will also establish a dose response relationship between acrylonitrile administration and extent of ..
  14. OTIC PROBE FOR NEUROCOCHLEAR INTRAOPERATIVE MONITORING
    Rafael Delgado; Fiscal Year: 2003
    ..probe will also have treatment capability in the form of irrigation and suction to present medications to the round window and inner ear...
  15. DOPPLER ULTRASOUND COCHLEAR BLOODFLOW MONITOR
    Arne Voie; Fiscal Year: 2000
    ..The device will detect blood flow via the round window niche, which is easily accessible and outside the acoustic neuroma operating field...
  16. POSTNATAL AUDITORY FUNCTION DEVELOPMENT
    GEORGE STRAIN; Fiscal Year: 1991
    ..and brainstem auditory evoked potential will be recorded using electrodes surgically implanted on the round window 24-48 hours after birth...
  17. OTIC PROBE FOR NEUROCOCHLEAR INTRAOPERATIVE MONITORING
    Fred Telischi; Fiscal Year: 2000
    ..Experiments in this laboratory have shown that changes in CBF can be reliably measured from the round window of rabbits using LD...
  18. EXPOSING MECHANICAL IMPEDANCE OF THE COCHLEAR PARTITION
    Elizabeth Olson; Fiscal Year: 2000
    ..5mm longitudinal extent of the cochlear partition to be accessed through the round window opening...
  19. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
    ..abstract_text> ..
  20. Ear Biomechanics for Restoration of Hearing
    RONG GAN; Fiscal Year: 2009
    ..Thus, the results will be essential for improving the diagnosis of OME, assessing surgical treatment for conductive hearing loss, and potentially improve the quality of life for millions of people. ..
  21. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
  22. CLINICAL MEASURES OF AUDITORY LINEAR/NONLINEAR PROCESSES
    MARK CHERTOFF; Fiscal Year: 2004
    ..abstract_text> ..
  23. Studies of cochlear mechanics: otoacoustic emissions
    Tianying Ren; Fiscal Year: 2005
    ..abstract_text> ..
  24. DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICS
    David Mills; Fiscal Year: 2003
    ..abstract_text> ..
  25. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  26. Drug manipulation of noise-induced hearing loss
    RICHARD BOBBIN; Fiscal Year: 2002
    ....
  27. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
    ..abstract_text> ..
  28. Middle-ear assessment via reflectance measurements
    Susan Voss; Fiscal Year: 2005
    ..This work will both strengthen the research environment at Smith College and provide substantial research experiences for undergraduate students. ..
  29. Peripherial and Central Mechanisms of Tinnitus Generat
    Carol Bauer; Fiscal Year: 2006
    ..Safe and efficacious therapy for this prevalent and often debilitating problem can only occur with improved understanding of the disorder. ..
  30. Mechanics of Hearing Meeting 2005
    Alfred Nuttall; Fiscal Year: 2005
    ..In addition, attendees will receive information and experience in how to be proactive in the area of public education for hearing science. ..
  31. Functional role of CGRP as an efferent neurotransmitter
    Colleen Le Prell; Fiscal Year: 2007
    ..2004). ..
  32. Exploring otoacoustic emissions with intracochlear pressure measurements
    Wei Dong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  33. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
  34. Auditory nerve responses to electric pulse trains
    Charles Miller; Fiscal Year: 2009
    ..We expect the results of this work will guide future designs of cochlear-implant speech processors so that modulated stimuli can be better tailored to the encoding capacity of the user's auditory nerve. ..
  35. Low Optical Coherence Interferometry for the Cochlea
    Alfred Nuttall; Fiscal Year: 2007
    ..abstract_text> ..
  36. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  37. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..