organ of corti

Summary

Summary: The organ that contains the special sensory receptors for hearing. It is composed of a series of epithelial structures placed upon the inner part of the basilar membrane.

Top Publications

  1. ncbi The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
  2. ncbi Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling
    Katherine Shim
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, California 94143, USA
    Dev Cell 8:553-64. 2005
  3. pmc Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Cell 16:58-69. 2009
  4. ncbi Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
    Patricia M White
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, California 90057, USA
    Nature 441:984-7. 2006
  5. pmc Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear
    Elizabeth C Oesterle
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, CHDD CD176, Box 357923, Seattle, WA 98195 7923, USA
    J Assoc Res Otolaryngol 9:65-89. 2008
  6. ncbi Immunodetection of surfactant proteins in human organ of Corti, Eustachian tube and kidney
    Orhan Kankavi
    Therapeutics Research Group, Deptartment of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Acta Biochim Pol 50:1057-64. 2003
  7. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
  8. ncbi Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea
    Bonnie E Jacques
    Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:3021-9. 2007
  9. pmc The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti
    Tian Yang
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
    Hear Res 278:21-33. 2011
  10. pmc Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa
    Martin L Basch
    Department of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 31:8046-58. 2011

Research Grants

  1. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
  2. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
  3. USHERIN: STRUCTURAL AND FUNCTIONAL ANALYSIS
    DOMINIC E COSGROVE; Fiscal Year: 2012
  4. Preventing hair cell loss by regulating prestin's function
    Jing Zheng; Fiscal Year: 2010
  5. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
  6. Cellular therapy for the inner ear
    Albert S Edge; Fiscal Year: 2013
  7. CONTROL OF INNER EAR MICROCIRCULATION
    Alfred L Nuttall; Fiscal Year: 2013
  8. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2013
  9. Morphogenesis of the organ of Corti
    Ping Chen; Fiscal Year: 2013
  10. REGULATION OF COCHLEAR REGENERATION BY CANONICAL WNT SIGNALING
    MATTHEW RYAN BARTON; Fiscal Year: 2012

Detail Information

Publications295 found, 100 shown here

  1. ncbi The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
    During embryonic development of the inner ear, the sensory primordium that gives rise to the organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of inner and outer sensory hair cells separated from ..
  2. ncbi Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling
    Katherine Shim
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, California 94143, USA
    Dev Cell 8:553-64. 2005
    The auditory sensory epithelium (organ of Corti), where sound waves are converted to electrical signals, comprises a highly ordered array of sensory receptor (hair) cells and nonsensory supporting cells...
  3. pmc Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Cell 16:58-69. 2009
    The organ of Corti, the auditory organ of the inner ear, contains two types of sensory hair cells and at least seven types of supporting cells...
  4. ncbi Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
    Patricia M White
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, California 90057, USA
    Nature 441:984-7. 2006
    Sensory hair cells of the mammalian organ of Corti in the inner ear do not regenerate when lost as a consequence of injury, disease, or age-related deafness...
  5. pmc Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear
    Elizabeth C Oesterle
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, CHDD CD176, Box 357923, Seattle, WA 98195 7923, USA
    J Assoc Res Otolaryngol 9:65-89. 2008
    ..The present study delineates a protocol to drug damage the adult mouse auditory epithelium (organ of Corti) in situ and uses this protocol to investigate Sox2 and Jagged1 expression in damaged inner ear sensory ..
  6. ncbi Immunodetection of surfactant proteins in human organ of Corti, Eustachian tube and kidney
    Orhan Kankavi
    Therapeutics Research Group, Deptartment of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Acta Biochim Pol 50:1057-64. 2003
    The presence of surfactant proteins was investigated in the human organ of Corti, Eustachian tube and kidney tissues...
  7. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
    ..Only the posterior canal crista has Atoh1 expressing hair cells due to incomplete recombination. Most of the organ of Corti cells are lost in CKO mice via late embryonic cell death...
  8. ncbi Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea
    Bonnie E Jacques
    Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:3021-9. 2007
    The mammalian auditory sensory epithelium (the organ of Corti) contains a number of unique cell types that are arranged in ordered rows...
  9. pmc The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti
    Tian Yang
    Department of Biology, College of Liberal Arts and Sciences, University of Iowa, 143 BB, Iowa City, IA 52242, USA
    Hear Res 278:21-33. 2011
    ..They project radial fibers to innervate the organ of Corti (type I neurons to inner hair cells, type II neurons to outer hair cells) and also project tonotopically to ..
  10. pmc Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa
    Martin L Basch
    Department of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 31:8046-58. 2011
    The mammalian organ of Corti consists of a highly organized array of hair cells and supporting cells that originate from a common population of prosensory progenitors...
  11. ncbi Postnatal maturation of the organ of Corti in gerbils: morphology and physiological responses
    M Souter
    Institute of Laryngology and Otology, University College London Medical School, England
    J Comp Neurol 386:635-51. 1997
    The organ of Corti, the sensory epithelium of hearing in mammals, matures postnatally in the gerbil...
  12. ncbi A physiological place-frequency map of the cochlea in the CBA/J mouse
    Marcus Müller
    Physiologisches Institut II, J W Goethe Universität Frankfurt, Germany
    Hear Res 202:63-73. 2005
    ..From the neuronal characteristic frequency (CF) and the innervation site in the organ of Corti a place-frequency map was established for characteristic frequencies between 7.2 and 61...
  13. pmc Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea
    Ruth R Taylor
    Centre for Auditory Research, The Ear Institute, University College London, London, United Kingdom
    PLoS ONE 7:e30577. 2012
    ..For any cell replacement strategy to be successful, the cellular environment of the injured tissue has to be able to nurture new hair cells. This study defines characteristics of the auditory sensory epithelium after hair cell loss...
  14. pmc In vivo outer hair cell length changes expose the active process in the cochlea
    Dingjun Zha
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e32757. 2012
    ..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification...
  15. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
    ..Finally, we demonstrate techniques for the precise dissection of organ of Corti and its substructures, while preserving their near normal chemical state...
  16. pmc Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:056005. 2010
    ..However, the biomechanical mechanisms of how the hearing organ, i.e., the organ of Corti (OC), responds to sound are still elusive, largely because there is currently no means available to image the ..
  17. ncbi Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs
    A Forge
    Institute of Laryngology and Otology, University College London, United Kingdom
    J Comp Neurol 397:69-88. 1998
    ..There was also no evidence of any hair cell recovery in the organ of Corti. Thus, there appear to be limitations on the capacity for spontaneous replacement of lost hair cells in the ..
  18. ncbi The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 132:4353-62. 2005
    The mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arranged in a highly patterned mosaic...
  19. ncbi Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture
    Johann Gross
    Molecular Biology Research Laboratory, Department of Otorhinolaryngology, Institute of Cell and Neurobiology, Charite Universitatsmedizin Berlin, 10117 Berlin, Chariteplatz 1, Germany
    Hear Res 261:9-21. 2010
    ..To prove this, we examined in parallel the expression of mRNA of prestin and Gata-3,-2 and Gata-1 in the organ of Corti during early postnatal development of rats and in organotypic cultures...
  20. ncbi Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
    Raphaël Etournay
    Unite de Genetique et Physiologie de l Audition, INSERM UMRS587 Université Paris VI, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, France
    Development 137:1373-83. 2010
    ..We propose that this remodeling contributes to optimize the mechanical coupling between the basal and apical poles of mature OHCs...
  21. pmc Regulation of cell fate and patterning in the developing mammalian cochlea
    Matthew W Kelley
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Otolaryngol Head Neck Surg 17:381-7. 2009
    ..proportion of hearing loss and deafness is caused by defects in the structure or function of cells within the organ of Corti. Identification of the molecular factors that regulate the development of this structure should provide ..
  22. ncbi Cytological changes related to maturation of the organ of Corti and opening of Corti's tunnel
    M Ito
    Department of Pathology and Laboratory of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Hear Res 88:107-23. 1995
    Maturation of the organ of Corti in the gerbil was analyzed between 2 and 16 days after birth (DAB) by electron microscopy and immunostaining for beta-tubulin...
  23. ncbi Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti
    Jennifer M Jones
    Section on Developmental Neuroscience, Porter Neuroscience Center, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:550-8. 2006
    ..These results indicate a key role for Ids in the regulation of expression of Math1 and hair cell differentiation in the developing cochlea...
  24. pmc Force transmission in the organ of Corti micromachine
    Jong Hoon Nam
    Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Biophys J 98:2813-21. 2010
    ..Either process must exert its mechanical effect via deformation of the organ of Corti, a complex assembly of sensory and supporting cells riding on the basilar membrane...
  25. pmc Targeted connexin26 ablation arrests postnatal development of the organ of Corti
    Yunfeng Wang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Biochem Biophys Res Commun 385:33-7. 2009
    ..However, postnatal development of the organ of Corti was stalled as the tunnel of Corti and the Nuel's space were never opened...
  26. ncbi A genetic approach to understanding auditory function
    K P Steel
    Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham, UK
    Nat Genet 27:143-9. 2001
    ..We review here some of the major advances in our understanding of auditory function resulting from the recent rapid progress in identification of genes involved in deafness...
  27. ncbi Pronounced infracuticular endocytosis in mammalian outer hair cells
    J Meyer
    Department of Otolaryngology, Section of Physiological Acoustics and Communication, University of Tubingen, Germany
    Hear Res 161:10-22. 2001
    ....
  28. ncbi Cellular commitment and differentiation in the organ of Corti
    Matthew W Kelley
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA
    Int J Dev Biol 51:571-83. 2007
    The organ of Corti, the sensory epithelium of the mammalian cochlea, develops from a subset of cells located along the dorsal side (referred to as the floor) of the cochlear duct...
  29. ncbi Organ of Corti potentials and the motion of the basilar membrane
    Anders Fridberger
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Neurosci 24:10057-63. 2004
    ..Therefore, Dallos and Evans (1995a) proposed that extracellular potential changes within the organ of Corti could drive cellular motor proteins. These extracellular potentials are not filtered by the membrane...
  30. pmc Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation
    Maxime Bouchard
    Biochemistry Department, Goodman Cancer Centre, McGill University, Quebec, Canada
    BMC Dev Biol 10:89. 2010
    ..Past research has suggested various cochlear defects and some vestibular defects in Pax2 null mice but the details of the cochlear defects and the interaction with other Pax family members in ear development remain unclear...
  31. pmc The small GTPase Rac1 regulates auditory hair cell morphogenesis
    Cynthia M Grimsley-Myers
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 29:15859-69. 2009
    ..Together, these results reveal a critical function of Rac1 in morphogenesis of the auditory sensory epithelium and stereociliary bundle...
  32. pmc Supporting cell division is not required for regeneration of auditory hair cells after ototoxic injury in vitro
    Jialin Shang
    Department of Otolaryngology Head and Neck Surgery, The Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, WA 98195 7923, USA
    J Assoc Res Otolaryngol 11:203-22. 2010
    ..These observations demonstrate that direct transdifferentiation is a significant mechanism of hair cell regeneration in the chicken auditory after streptomycin damage in vitro...
  33. ncbi Novel variant of the P2X2 ATP receptor from the guinea pig organ of Corti
    M S Parker
    Department Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70112 2234, USA
    Hear Res 121:62-70. 1998
    ..Evidence suggests that ATP activates P2X receptors on several cell types in the organ of Corti of guinea pig including outer hair cells (OHCs), Deiters' cells, Hensen's cells, pillar cells and inner hair ..
  34. pmc Dissecting the molecular basis of organ of Corti development: Where are we now?
    Bernd Fritzsch
    Department of Biology, College of Liberal Arts and Sciences, 143 BB, University of Iowa, Iowa City, IA 52242, USA
    Hear Res 276:16-26. 2011
    ..recent progress in our understanding of the molecular basis of cochlear duct growth, specification of the organ of Corti, and differentiation of the different types of hair cells...
  35. pmc Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti
    Misato Yoshikawa
    Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan
    Proc Natl Acad Sci U S A 106:9483-8. 2009
    ..of hearing and had been completely lost by 17 days after birth (P17), showing a deformity in hair cells in the organ of Corti. By 2 months of age, the organ of Corti had selectively and completely disappeared without effect on balance ..
  36. pmc Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti
    H Löwenheim
    Department of Otolaryngology, University of Tubingen, Silcherstrasse 5, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 96:4084-8. 1999
    ..In the postembryonic and adult mammalian auditory sensory epithelium, the organ of Corti, no hair-cell regeneration has ever been observed...
  37. pmc The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice
    Melanie Schütz
    Institut fuer Genetik, Rheinische Friedrich Wilhelms Universitaet Bonn, Roemerstrasse 164, D 53117 Bonn, Germany
    Hum Mol Genet 19:4759-73. 2010
    ..Our findings link hearing loss to decreased biochemical coupling due to the point-mutated Cx30 in mice...
  38. pmc Calcium balance and mechanotransduction in rat cochlear hair cells
    Maryline Beurg
    Institut National de la Santé et de la Recherche Médicale U587, Universite Victor Segalen Bordeaux 2, Hopital Pellegrin, Bordeaux, France
    J Neurophysiol 104:18-34. 2010
    ..The model also indicated the endogenous mobile buffer was equivalent to 1 mM BAPTA...
  39. pmc Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9
    A K Lalwani
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Hum Genet 67:1121-8. 2000
    ..MYH9 was immunolocalized in the organ of Corti, the subcentral region of the spiral ligament, and the Reissner membrane...
  40. ncbi p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:1434-44. 2007
    ....
  41. ncbi Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice
    A Inoshita
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Neuroscience 156:1039-47. 2008
    ..The present study attempted to evaluate postnatal development of the organ of Corti in the R75W+ mice...
  42. ncbi The molecular architecture of the inner ear
    Andrew Forge
    UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, UK
    Br Med Bull 63:5-24. 2002
    ..This work is providing new insights into how the tissues of the inner ear are built to perform their tasks, and into the pathogenesis of a range of inner ear disorders...
  43. ncbi Expression of alpha and beta parvalbumin is differentially regulated in the rat organ of corti during development
    D Yang
    Siebens Hearing Research Center, Central Institute for the Deaf, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurobiol 58:479-92. 2004
    ..This study suggests that OM and alphaPV are differentially regulated in OHCs during cochlear development. Our findings further raise the possibility that the expression of PV proteins in OHCs may be influenced by efferent innervation...
  44. pmc Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation
    Corey S Frucht
    Medical Scientist Training Program, Yale School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e11502. 2010
    ....
  45. ncbi The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea
    Elisabeth Glowatzki
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 26:7659-64. 2006
    ..dendrites, and glial cells adjacent to IHCs [inner phalangeal cells (IPCs)] in whole-mount preparations of rat organ of Corti. Focal application of the transporter substrate D-aspartate elicited inward currents in IPCs, which were ..
  46. pmc Specification of cell fate in the mammalian cochlea
    Elizabeth C Driver
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 87:212-21. 2009
    Mammalian auditory sensation is mediated by the organ of Corti, a specialized sensory epithelium found in the cochlea of the inner ear...
  47. ncbi Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness
    Takayuki Kudo
    Department of Medical Genetics, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Mol Genet 12:995-1004. 2003
    ..an extracellular space surrounding the sensory hair cells, due to impaired K(+) transport by supporting cells, resulting in degradation of the organ of Corti, rather than affecting endolymph homeostasis in mice and probably in humans.
  48. pmc BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice
    Giulia Crispino
    Fondazione per la Ricerca Biomedica Avanzata, Istituto Veneto di Medicina Molecolare, Padova, Italy
    PLoS ONE 6:e23279. 2011
    ....
  49. pmc Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti
    Katherine B Szarama
    Auditory Mechanics Section, Laboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Bioarchitecture 2:214-9. 2012
    ..the surface stiffness of sensory outer hair cells (OHCs) and non-sensory supporting pillar cells (PCs) in the organ of Corti. Here, we used Atomic Force Microscopy (AFM) to measure the impact of loss of function of Fgf-receptor 3, on ..
  50. ncbi An in vivo tracer study of noise-induced damage to the reticular lamina
    Mueed Ahmad
    Washington University School of Medicine, Department of Otolaryngology, Box 8115, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 175:82-100. 2003
    ..Damage in the organ of Corti (OC) was quantified, the location of carbon was determined, and some OC segments were then sectioned radially...
  51. pmc Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective
    Bernd Fritzsch
    Department of Biology, University of Iowa, CLAS, 143 BB, Iowa City, IA, 52242, USA
    Evol Dev 15:63-79. 2013
    The tetrapod auditory system transmits sound through the outer and middle ear to the organ of Corti or other sound pressure receivers of the inner ear where specialized hair cells translate vibrations of the basilar membrane into ..
  52. ncbi Olivocochlear efferent innervation of the organ of corti in hypothyroid rats
    Raquel Cantos
    Departamento de Histología y Anatomía, Facultad de Medicina, Universidad Miguel Hernandez, Alicante, Spain
    J Comp Neurol 459:454-67. 2003
    ..Because the number of neurons which develop into the efferent innervation was normal in hypothyroid animals, we conclude that medial fibers may contact a new target...
  53. ncbi Endothelial nitric oxide synthase upregulation in the guinea pig organ of Corti after acute noise trauma
    Ulf Rüdiger Heinrich
    Department of Otolaryngology Head and Neck Surgery, Johannes Gutenberg University Medical School, 55131 Mainz, Germany
    Brain Res 1047:85-96. 2005
    ..was identified 60 h after acute noise trauma in morphologically intact cells of the reticular lamina in the organ of Corti of the guinea pig in the second turn of the cochlea...
  54. ncbi Temporal bone histopathology in alport syndrome
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Laryngoscope 114:1609-18. 2004
    ..To determine the histopathologic abnormalities within the cochlea in Alport syndrome...
  55. ncbi Expression of p75NTR and its associated protein NADE in the rat cochlea
    H Sano
    Department of Otolaryngology, School of Medicine, Kitasato University, Sagamihara, Japan
    Laryngoscope 111:535-8. 2001
    ..Studies such as this one will help to predict the functional role of p75NTR and NADE in cochlear development...
  56. ncbi Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission
    A Minekawa
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Neuroscience 164:1312-9. 2009
    ..The present study indicates that normal development of the supporting cells is indispensable for proper cellular function of the OHC...
  57. pmc Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging
    Maryline Beurg
    INSERM U, Universite Victor Segalen Bordeaux, Hopital Pellegrin, France
    Nat Neurosci 12:553-8. 2009
    ..The observations, supported by theoretical simulations, suggest there are no functional mechanically sensitive transducer channels in first row stereocilia and imply the channels are present only at the bottom of the tip links...
  58. ncbi Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha-induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes
    C T Dinh
    Cochlear Implant Research Program, University of Miami Ear Institute, Department of Otolaryngology, University of Miami, Miller School of Medicine, 1600 Northwest 10th Avenue, RMSB 3160, Miami, FL 33136 1015, USA
    Neuroscience 157:405-13. 2008
    ..Determine the molecular mechanism(s) behind tumor necrosis factor-alpha (TNFalpha)-induced loss of auditory hair cells and the ability of dexamethasone base (DXMb) to protect against TNFalpha ototoxicity...
  59. pmc Cell type-specific reduction of beta tubulin isotypes synthesized in the developing gerbil organ of Corti
    Heather C Jensen-Smith
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurocytol 32:185-97. 2003
    ..In the adult organ of Corti, each of the five major cell types synthesizes a different subset of isotypes...
  60. ncbi MicroRNA gene expression in the mouse inner ear
    Michael D Weston
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska, NE 68178, USA
    Brain Res 1111:95-104. 2006
    ....
  61. pmc Traveling waves on the organ of corti of the chinchilla cochlea: spatial trajectories of inner hair cell depolarization inferred from responses of auditory-nerve fibers
    Andrei N Temchin
    Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208 3550, USA
    J Neurosci 32:10522-9. 2012
    ..stimulus to their stereocilia, the present results suggest that distinct low-frequency forward waves of organ of Corti vibration are launched simultaneously at the extreme base of the cochlea and at the 6...
  62. ncbi Relation of focal hair-cell lesions to noise-exposure parameters from a 4- or a 0.5-kHz octave band of noise
    Gary W Harding
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 254:54-63. 2009
    ..into recovery times of 0 days (acute) and >0 days (chronic) and the apical and basal halves of the organ of Corti (OC). A substantial part of these hair-cell losses occurred in focal lesions (i.e...
  63. pmc Myosin II regulates extension, growth and patterning in the mammalian cochlear duct
    Norio Yamamoto
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Development 136:1977-86. 2009
    ..Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns...
  64. pmc Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss
    Qian Zhang
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, United States of America
    PLoS ONE 8:e62786. 2013
    ..We questioned which miRNAs are involved in age-related degeneration of the organ of Corti (OC), the auditory sensory epithelium that transduces mechanical stimuli to electrical activity in the inner ..
  65. ncbi p27(Kip1) deficiency causes organ of Corti pathology and hearing loss
    Sho Kanzaki
    Kresge Hearing Research Institute, The University of Michigan Medical School, MSRB III Room 9303, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0648, USA
    Hear Res 214:28-36. 2006
    ..Once hair cells in the cochlea are formed, p27 is expressed in non-sensory cells of the organ of Corti and prevents their re-entry into the cell cycle...
  66. ncbi Chlorpromazine alters cochlear mechanics and amplification: in vivo evidence for a role of stiffness modulation in the organ of corti
    Jiefu Zheng
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, NRC04, Portland, OR 97239 3098, USA
    J Neurophysiol 97:994-1004. 2007
    ....
  67. ncbi Ototoxic drugs: difference in sensitivity between mice and guinea pigs
    A L Poirrier
    Department of Otolaryngology, University Hospital of Liege, Liege, Belgium
    Toxicol Lett 193:41-9. 2010
    ..These results indicate that the mouse is not a good model for ototoxicity, which should be taken into consideration in all further investigations concerning ototoxicity-induced hearing loss...
  68. ncbi Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation
    Nicolas Daudet
    Vertebrate Development Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 132:541-51. 2005
    ..Subsequently, Notch signalling within each such patch mediates lateral inhibition, restricting the proportion of cells that differentiate as hair cells so as to generate the fine-grained mixture of hair cells and supporting cells...
  69. ncbi Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti
    E V Leonova
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0648, USA
    Hear Res 113:14-28. 1997
    The reticular lamina creates an ion barrier, withstands mechanical stress in the organ of Corti and is able to maintain its integrity during and after severe hair cell loss...
  70. pmc Vibration pattern of the organ of Corti up to 50 kHz: evidence for resonant electromechanical force
    Marc P Scherer
    Department of Otolaryngology, Tübingen Hearing Research Centre, Section of Physiological Acoustics and Communication, University of Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 101:17652-7. 2004
    ..attenuated and phase-shifted by the electrical impedance of the cell and the mechanical impedance of the organ of Corti, respectively...
  71. pmc Notch signaling and Hes labeling in the normal and drug-damaged organ of Corti
    Shelley A Batts
    Kresge Hearing Research Institute, University of Michigan Medical School, MSRB 3, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5648, USA
    Hear Res 249:15-22. 2009
    ..signaling ends during maturity and cannot be reinitiated to alter the fate of new or existing cells in the organ of Corti. This is in contrast to non-mammalian species which reinitiate Delta 1-Notch1 signaling in response to trauma ..
  72. pmc Metabolic imaging of the organ of corti--a window on cochlea bioenergetics
    LeAnn Tiede
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Brain Res 1277:37-41. 2009
    ..Using this method, we show evidence that the aminoglycoside gentamicin selectively affects the level of mitochondrial NADH in outer hair cells, but not inner hair cells, within minutes of administration...
  73. pmc Response to a pure tone in a nonlinear mechanical-electrical-acoustical model of the cochlea
    Julien Meaud
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 102:1237-46. 2012
    ..The three-dimensional intracochlear fluid dynamics are coupled to a micromechanical model of the organ of Corti and to electrical potentials in the cochlear ducts and outer hair cells (OHC)...
  74. pmc Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Hum Mol Genet 17:3340-56. 2008
    ..These results also provide a molecular mechanism for understanding how hypomorphic levels of EYA1 cause inner-ear defects in humans...
  75. pmc The role of organ of Corti mass in passive cochlear tuning
    Ombeline de La Rochefoucauld
    Department of Otolaryngology, Head and Neck Surgery, Columbia University, New York, New York, USA
    Biophys J 93:3434-50. 2007
    The mechanism for passive cochlear tuning remains unsettled. Early models considered the organ of Corti complex (OCC) as a succession of spring-mass resonators...
  76. ncbi Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice
    Azel Zine
    Institute of Physiology, University of Lausanne, 7 rue du Bugnon, CH 1005, Lausanne, Switzerland
    Hear Res 170:22-31. 2002
    The sensory epithelium of the mammalian cochlea (the organ of Corti) represents an excellent developmental system...
  77. ncbi RNA expression induced by cisplatin in an organ of Corti-derived immortalized cell line
    Maurizio Previati
    Department of Morphology and Embryology, Human Anatomy Division, Ferrara University Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Hear Res 196:8-18. 2004
    ..generation of reactive oxygen species (ROS), that can impair morphology and function of hair cells (HC) in the organ of Corti. To test this hypothesis we evaluated the effect of CDDP treatment on RNA steady-state levels of 15,000 genes ..
  78. ncbi Synaptophysin immunohistochemistry in the human cochlea
    Shaden Ali M Khalifa
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, 751 85 Uppsala, Sweden
    Hear Res 185:35-42. 2003
    ..was solely restricted to the neural and sensory structures and did not include supporting cells of the organ of Corti. Dense reaction products were noted around the hair cells, especially at the basal portion of the inner and ..
  79. ncbi Lipopolysaccharide-induced expression of inducible nitric oxide synthase in the guinea pig organ of Corti
    M Takumida
    Department of Otolaryngology, Hiroshima University School of Medicine, 1 2 3 Kasumicho, Minamiku, Hiroshima, Japan
    Hear Res 140:91-8. 2000
    ..also revealed intense immunoreactivity identical to that of iNOS, suggesting formation of peroxynitrite in the organ of Corti by the reaction of NO with O(2)(-)...
  80. ncbi In vivo imaging and low-coherence interferometry of organ of Corti vibration
    Fangyi Chen
    Oregon Health and Science University, Oregon Hearing Research Center, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, Oregon 97239 3098, USA
    J Biomed Opt 12:021006. 2007
    ..coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig...
  81. ncbi Sex differences in the length of the organ of Corti in humans
    James D Miller
    Communication Disorders Technology, Inc, Indiana University Research Park, Bloomington 47404, USA
    J Acoust Soc Am 121:EL151-5. 2007
    ..11 mm in length and to 0.49 SD. The mean lengths of the male and female cochleas are approximately 34 and 33 mm, respectively, and the population SD is 2.28 mm. The statistical significance of the observed difference is questionable...
  82. ncbi Distribution of focal lesions in the chinchilla organ of Corti following exposure to a 4-kHz or a 0.5-kHz octave band of noise
    Gary W Harding
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 225:50-9. 2007
    ..e., combined lesions) in a specific region of the organ of Corti (OC)...
  83. ncbi MRNA expression of members of the IGF system in the organ of Corti, the modiolus and the stria vascularis of newborn rats
    Johann Gross
    Molecular Biology Research Laboratory, Department of Otorhinolaryngology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Growth Factors 26:180-91. 2008
    ..pathway genes using the Affymetrix microarray system and confirmatory RT-PCR in the freshly prepared organ of Corti (OC), modiolus (MOD) and stria vascularis (SV) from neonatal rats (3-5 days old) and after 24h in culture...
  84. ncbi p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    P Chen
    Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 126:1581-90. 1999
    ..The organ of Corti, the auditory neuroepithelium of the inner ear in mammals, consists of two types of terminally differentiated ..
  85. ncbi The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture
    M W Kelley
    Department of Otolaryngology HNS, University of Virginia School of Medicine, Charlottesville 22908
    Development 119:1041-53. 1993
    The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length...
  86. ncbi Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo
    Hongyan Jiang
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA
    J Neurochem 99:269-76. 2006
    ..Immunoreactivity to phosphatidylinositol-3,4,5-trisphosphate (PIP3) decreased in the organ of Corti, especially in outer hair cells, after 3-7 days of drug treatment, whereas imunoreactivity to ..
  87. ncbi E-cadherin in the mature and developing organ of Corti of the mouse
    D S Whitlon
    Waisman Center, University of Wisconsin, Madison 53705
    J Neurocytol 22:1030-8. 1993
    ..Cochleas aged E15 to P31 were stained immunocytochemically for E-cadherin. In the P31 organ of Corti, E-cadherin is localized to the apical intercellular junctions of supporting cells, but is absent from ..
  88. pmc Age-related hearing loss and the ahl locus in mice
    Elizabeth M Keithley
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0666, USA
    Hear Res 188:21-8. 2004
    ..These results illustrate the complex inheritance of age-related hearing loss in mice and may have implications for the study of human presbycusis...
  89. pmc Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis
    David H Nichols
    Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    Cell Tissue Res 334:339-58. 2008
    ..The adult Lmx1a mutant organ of Corti shows a loss of cochlear hair cells, suggesting that the long-term maintenance of hair cells is also disrupted ..
  90. ncbi High resolution scanning electron microscopy of the human organ of Corti. A study using freshly fixed surgical specimens
    Rudolf Glueckert
    Department of Otolaryngology, Medical University of Innsbruck, Anichstr 35, A 6020 Innsbruck, Austria
    Hear Res 199:40-56. 2005
    ..The characteristics of neural innervation, the pathways of the nerves through the organ of Corti and the intimate relation of nerves to supporting cells along their route could be studied in detail...
  91. pmc Distribution of the Na,K-ATPase alpha subunit in the rat spiral ganglion and organ of corti
    Will J McLean
    Department of Biology and Marine Biology, University of North Carolina Wilmington, 601 South College Road, Wilmington, NC 28403, USA
    J Assoc Res Otolaryngol 10:37-49. 2009
    ..and markers identifying particular subsets of neurons or supporting cells in whole mount preparations of the organ of Corti and spiral ganglion...
  92. pmc Organ of Corti kinematics
    Peter Dallos
    Auditory Physiology Laboratory, The Hugh Knowles Center and Neuroscience Institute, Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA
    J Assoc Res Otolaryngol 4:416-21. 2003
    The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model...
  93. ncbi Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti
    Ingrid Breuskin
    GIGA Neurosciences, University of Liege, Belgium
    Dev Biol 335:327-39. 2009
    ..vesicle epithelium and becomes later restricted to supporting cells as cell differentiation proceeds in the organ of Corti. Morphological analyses of Sox10 mutant mice reveal a significant shortening of the cochlear duct likely ..
  94. ncbi Cellular growth and rearrangement during the development of the mammalian organ of Corti
    Erynn McKenzie
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, USA
    Dev Dyn 229:802-12. 2004
    The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of ordered rows of cells, including inner and outer hair cells...
  95. ncbi A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development
    Yun Shain Lee
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 133:2817-26. 2006
    ..the number of postmitotic progenitors destined to give rise to the hair cells and supporting cells of the organ of Corti. Interestingly, transcriptional induction from the p27(Kip1) gene occurs normally in p27(Kip1)-null mice, ..
  96. pmc Genetic and pharmacological intervention for treatment/prevention of hearing loss
    Douglas A Cotanche
    Laboratory of Cellular and Molecular Hearing Research, Department of Otolaryngology, Children s Hospital Boston, Boston, MA, USA
    J Commun Disord 41:421-43. 2008
    ....
  97. ncbi Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness
    Martina Beltramello
    Venetian Institute of Molecular Medicine, via G Orus 2, 35129 Padua, Italy
    Nat Cell Biol 7:63-9. 2005
    ..Injection of Ins(1,4,5)P(3) into supporting cells of the rat organ of Corti, which abundantly express Cx26, ensues in a regenerative wave of Ca(2+) throughout the tissue...
  98. ncbi Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea
    Daniel J Jagger
    Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, United Kingdom
    J Neurosci 26:1260-8. 2006
    ..Furthermore, they suggest that separate medial and lateral buffering compartments exist in the hearing cochlea, which are individually dedicated to the homeostasis of inner hair cells and outer hair cells...
  99. ncbi Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti
    Valeria Piazza
    Venetian Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, via G Orus 2, 35129 Padua, Italy
    Cell Calcium 41:77-86. 2007
    ..Further ongoing research will reveal the roles that such Ca2+ waves play in the inner ear...
  100. ncbi Recombinant human erythropoietin prevents ischemia-induced apoptosis and necrosis in explant cultures of the rat organ of Corti
    Nadezhda Andreeva
    Brain Research Institute, Academy of Medical Sciences, Odukha 5, 105064 Moscow, Russia
    Neurosci Lett 396:86-90. 2006
    ..rhEPO has been in clinical use for more than a decade and found to be well tolerated. Therefore, rhEPO could be an effective drug for the prevention of hearing loss via a hair cell protective mechanism...
  101. pmc Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti
    C Eduardo Corrales
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Neurobiol 66:1489-500. 2006
    ..transplantation, the grafts had neurons that extended processes from the nerve core toward the denervated organ of Corti. By 64-98 days, the grafts had sent out abundant processes that occupied a significant portion of the space ..

Research Grants67

  1. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ..this new investigation, we will focus on the role of serotonin as an efferent transmitter within the auditory organ of Corti and as a receptoneural transmitter in vestibular hair cells...
  2. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..mice to determine whether CD36 is essential for the recognition and removal of apoptotic hair cells from the organ of Corti. We will also use radiation bone marrow chimeras to isolate the effects of CD36 expression on leukocytes ..
  3. USHERIN: STRUCTURAL AND FUNCTIONAL ANALYSIS
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..transport in stereociliary development and maintenance by blocking vesicle transport in cultures of mouse organ of Corti and by immunohistological analysis of usher proteins in usher mouse models...
  4. Preventing hair cell loss by regulating prestin's function
    Jing Zheng; Fiscal Year: 2010
    ..Why OHCs, as compared to other cells in the organ of Corti, are more vulnerable to ROS is not fully understood...
  5. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
    ..The experiments will be carried out in the cultured organ of Corti from neonatal gerbils...
  6. Cellular therapy for the inner ear
    Albert S Edge; Fiscal Year: 2013
    ..Our previous work has shown that neurons from transplanted stem cells can reinnervate hair cells of the organ of Corti after chemical de- afferentation, both in an in vitro explant and in an in vivo gerbil model, suggesting that ..
  7. CONTROL OF INNER EAR MICROCIRCULATION
    Alfred L Nuttall; Fiscal Year: 2013
    ..the metabolic load and hypoxia induced by loud sound impacts mitochondria morphology and the redox state of organ of Corti hair cells. Under the first point there are three specific questions about lateral blood flow and stress...
  8. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2013
    ..NRG1, produced by cochlear and vestibular sensory neurons, induces supporting cells to express NTs, NT3 in the organ of Corti and BDNF in the vestibular epithelia...
  9. Morphogenesis of the organ of Corti
    Ping Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The organ of Corti consists of 4 parallel rows of sensory hair cells along the length of the cochlear duct...
  10. REGULATION OF COCHLEAR REGENERATION BY CANONICAL WNT SIGNALING
    MATTHEW RYAN BARTON; Fiscal Year: 2012
    ..that result from Wnt inhibition, and (3) to characterize the effects of Wnt modulation in the developing mouse organ of Corti. The outcome of these experiments will clarify the role of canonical Wnt signaling in the cochleae of birds ..
  11. Regulation of hair cell determination by the Wnt/Calcium signaling pathway
    Alain Dabdoub; Fiscal Year: 2012
    ..Within the organ of Corti, a single row of inner hair cells and three rows of outer hair cells extend along the basal-to-apical axis of ..
  12. Acoustic and electrical hearing after Atoh1 treatment
    Bryan E Pfingst; Fiscal Year: 2010
    ..by applicant): We have recently demonstrated that new inner hair cells (IHCs) are generated in the mammalian organ of Corti following gene therapy...
  13. Sensory cell fate specification in the inner ear
    Douglas J Epstein; Fiscal Year: 2012
    ..signaling is required for the specification and/or differentiation of hair cells and support cells in the organ of corti and cristae of the semicircular canals...
  14. Gene Expression in Rat Cochlea Following Loss of Hair Cells
    Erin Bailey; Fiscal Year: 2013
    ..Alternative sources for neurotrophic support include supporting cells of the organ of Corti, the cochlear nucleus, and spiral ganglion Schwann cells...
  15. DYNAMIC INTERATION AMONG PROTEINS IN HAIR CELLS
    Jing Zheng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The organ of Corti in the inner ear converts the mechanical force arising from sound waves into electrical signals to inform the central nervous system...
  16. Pluripotent Stem Cell Technology for the Study and treatment of Human hearing los
    Samuel Paul Gubbels; Fiscal Year: 2013
    ..transplanted into the adult mammalian inner ear do not integrate into the auditory sensory epithelium (the organ of Corti) as hair cells. The two specific aims described in this grant directly address these immediate challenges...
  17. Developmental Mechanisms of Vestibular Maculae Patterning in Mouse
    Michael R Deans; Fiscal Year: 2012
    ..Auditory hair cells within the organ of Corti detect sound in a similar fashion and the bundle polarity of adjacent cells is also coordinated...
  18. Cell cycle in development and regeneration of the inner ear
    Neil Segil; Fiscal Year: 2011
    ..The loss of regenerative ability is tied to the inability of the specialized supporting cells within the organ of Corti to begin dividing in response to hair cell death. We have taken a developmental approach to this problem...
  19. CLONING GENES INVOLVED IN HEARING
    CYNTHIA CASSON MORTON; Fiscal Year: 2012
    ..in DFNA9 by expression and proteomic analyses, (2) to continue to investigate human cochlear and mouse organ of Corti ESTs using bioinformatics approaches including use of custom cDNA microarrays, and to search for "new" ..
  20. 3-D optical imaging of the in vivo organ of Corti motion at a sub-nanometer scale
    Alfred L Nuttall; Fiscal Year: 2013
    ..We propose to develop an OCT interferometer that has the ability to both image the living organ of Corti and measure its cellular motion in 3-dimensions down to a vibration as small as 0.1 nm...
  21. Molecular Genetics of autosomal dominant non-syndromic hearing loss
    Xue Z Liu; Fiscal Year: 2013
    ..loss (HL) is non-syndromic, and is often neuroepithelial in origin arising from defects in the function of the organ of Corti - the site of auditory transduction in the inner ear...
  22. Dissecting Wnt/PCP Signaling in Developing Cochlear Sensory Epithelium
    Xiaowei Lu; Fiscal Year: 2012
    ..Aim 2 will determine the cell-autonomy of PTK7 in the organ of Corti and the role of proteolysis in regulating intra- and inter-cellular signaling activity of PTK7...
  23. Function of LIM-domain Transcriptional Regulators in Inner Ear Development
    Lin Gan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Loss of the inner ear hair cells in the organ of Corti is the leading cause of hearing loss that affects 278 million people worldwide, including 28 million in the ..
  24. Volumetric imaging of blood perfusion and tissue morphology in the cochlea
    Ruikang Wang; Fiscal Year: 2013
    ..The OCT mode of operation of the instrument provided images in the plane passing through the organ of Corti and scala media space that revealed the position of Reissner's membrane...
  25. SIGNALING MECHANISMS CONTROLLING PLANAR CELL POLARITY
    Jeffrey D Axelrod; Fiscal Year: 2013
    ..best characterized among these, PCP is required for the correct orientation of sensory hair cells in the organ of Corti of the inner ear, and defects result in deafness...
  26. PERIPHERAL MECHANISMS OF HEARING
    Mario A Ruggero; Fiscal Year: 2013
    ..membrane, the mechanical analyzer that separates sound into its frequency components and on which rests the organ of Corti and its hair cells, which convert vibrations into bioelectric potentials;the trains of action potentials that ..
  27. Genetic Regulation of Cochlear Development
    Andrew K Groves; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The organ of Corti is a sensory specialization of the mammalian cochlea that mediates our sense of hearing...
  28. In vivo Organ of Corti Mechanoelectric Physiology
    Alfred L Nuttall; Fiscal Year: 2013
    ..by applicant): A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti enhance the sound induced vibration of the basilar membrane, a process known as cochlear amplification (CA)...
  29. Three-dimensional and Multiscale Organ of Corti Biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..by applicant): There is not yet a single unifying theory of cochlear amplification consistent with the organ of Corti cytoarchitecture, basilar membrane mechanics, and otoacoustic emissions (OAEs)...
  30. ACTIVE AND NONLINEAR MODELS FOR COCHLEAR MECHANICS
    Karl Grosh; Fiscal Year: 2013
    ..specific aim 2 we seek to determine the tonotopic dependence and combined effect of active OHC forces on the organ of Corti and of the fluidic forces on the IHC HB...
  31. Functional development of hair cells
    GWENAELLE S GELEOC; Fiscal Year: 2013
    ..Interestingly, analysis of Tmc1 and Tmc2 mRNA expression during organ of Corti development revealed a tonotopic expression pattern and a developmental switch from Tmc2 to Tmc1 (Kawashima, G[..
  32. Defining Antigenic Targets of Autoimmune Sensorineural Hearing Loss
    Thomas E Carey; Fiscal Year: 2013
    ..CTL2 is prominently expressed on supporting cells within the organ of Corti. Binding of antibodies to this protein in the inner ear in vivo is accompanied by loss of inner ear hair cells ..
  33. EFFECTS OF CISPLATIN ON INNER EAR STEM CELLS
    Mark E Warchol; Fiscal Year: 2012
    ..We will determine whether cisplatin: (1) damages nuclear DNA within the mouse organ of Corti and (2) causes structural changes in cochlear supporting cells...
  34. OLIVOCOCHLEAR EFFERENT SYSTEMS AND COCHLEAR PHYSIOLOGY
    John J Guinan; Fiscal Year: 2012
    ..motion and understand how it is produced or amplified by OHCs, we will measure the motion of structures in the organ of Corti of the apical turn, and determine how these motions are affected by MOC stimulation and bias tones...
  35. Developmental patterning of the cochlea
    Takahiro Ohyama; Fiscal Year: 2013
    ..outer sulcus, (2) moderate levels of BMP signaling are required for the prosensory domain destined to form the organ of Corti, and (3) BMP signaling suppresses K[unreadable]lliker's organ...
  36. Otic progenitors via somatic cell nuclear reprogramming
    Stefan Heller; Fiscal Year: 2010
    ..directly applicable and highly useful for studies focusing on hair cell regeneration in the damaged mammalian organ of Corti as well as for developmental inner ear biology...
  37. MECHANISMS REGULATING COCHLEAR DEVELOPMENT
    Sung Ho Huh; Fiscal Year: 2013
    ..Examination of the inner ears of Fgf20-/- mice revealed that outer hair cells in the organ of Corti the sensory apparatus within the cochlea, were severely disrupted...
  38. Iowa Cochlear Implant Clinical Research Center Project VI
    Bruce Jay Gantz; Fiscal Year: 2013
    ..invasive electrodes in profoundly deaf infants, where they might help preserve the structural elements of the organ of Corti and enable this population to take advantage of ongoing future research to regenerate the peripheral auditory ..
  39. Scrutinize bHLH transcription factors mediated organ of Corti cell fate determina
    Israt Jahan; Fiscal Year: 2013
    ..Hearing defects in human can result in irreversible loss of HCs and SCs. Reconstitution of organ of Corti (OC) requires topologically correct organization of the two types of HCs, inner (IHC) and outer (OHC) hair ..
  40. ELECTRON MICROSCOPY OF THE HUMAN INNER EAR
    Joseph B Nadol; Fiscal Year: 2013
    ..Aim 3. Evaluate the preservation of supporting cells of the organ of Corti as possible candidates as progenitor cells in future regenerative therapy following cochlear implantation in ..
  41. Regulation of Myosin-X
    Hiroshi Tokuo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alterations in the cytoarchitecture of the organ of Corti (OC) cause hearing loss in humans...
  42. Reinnervation of inner hair cells following excitotoxic trauma
    Steven H Green; Fiscal Year: 2013
    ..in excitotoxically-damaged cochleae, we developed an organotypic cochlear explant in which a portion of the organ of Corti and corresponding portion of the spiral ganglion are removed intact, maintaining normal morphology and ..
  43. INNER EAR PROGENITOR CELLS
    Stefan Heller; Fiscal Year: 2013
    ..to determine correlation between occurrence of graft-derived hair cells and regionalized restoration of the organ of Corti. Physiologically, we expect that such a restoration may lead to alleviation of hair cell loss and hearing ..
  44. Regulation of sensory cell specification in the developing cochlea
    OLIVIA MARY BERMINGHAM-MCDONOGH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The development of the organ of Corti is a tightly regulated process, in which a small "prosensory" domain of the cochlear duct is sorted into various types of hair cells and support cells...
  45. Dissecting the cellular and molecular mechanism underlying planar cell polarity s
    CRISTY D TOWER-GILCHRIST; Fiscal Year: 2013
    ..Itis required for a multitude of cellular processes, including uniform orientation of hair cells in the organ of Corti of the cochlea and the dynamic convergent extension (CE) process...
  46. DEAFNESS AND OSSIFICATION IN LABYRINTHITIS OSSIFICANS
    Hilary Brodie; Fiscal Year: 2004
    ..for both labyrinthine fibrosis and ossification and the histopathology of cochlear tissues: spiral ganglion, organ of Corti, Reissner's membrane, stria vascularis, and spiral ligament; (3) to determine the relationship of bone lining ..
  47. Observing auditory mechanics with pressure and motion measurements
    Elizabeth S Olson; Fiscal Year: 2013
    ..by combining them with cochlear microphonic measurements at the same location, within micrometers of the organ of Corti. Both aims are designed to test specific theoretical predictions in order to have a strong impact on the ..
  48. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..under Specific Aim 1, we will define the path of potassium cycling that leads from the hair cells in the organ of Corti to strial marginal cells in stria vascularis Under Specific Aim 2, we will detelmine the subunit composition ..
  49. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
    ..This discovery of spontaneous purinergic signaling in the developing organ of Corti raises many new questions about the mechanisms responsible for producing this activity, the role that this ATP-..
  50. Role of connexins in cochlear functions
    Xi Lin; Fiscal Year: 2013
    ..that loss-of-function Cx26 mutations arrest normal morphological development of the hearing organ (the organ of Corti), and suggested that a failure to develop endocochlear potential (the battery that powers the hearing ..
  51. Hair Cell Regeneration in the Mature Mammalian Cochlea
    Yehoash Raphael; Fiscal Year: 2009
    Sensorineural hearing loss is most commonly a result of hair cell degeneration. Hair cells in the organ of Corti cannot be replaced once lost, and therefore, sensorineural hearing loss is permanent...
  52. MECHANOELECTRICAL TRANSDUCTION IN ADULT OUTER HAIR CELLS
    David He; Fiscal Year: 2004
    The outer hair cell (OHC) is one of two receptor cells in the organ of Corti, and plays a critical role in mammalian hearing...
  53. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    ..II afferents is not known, but we hypothesize that these neurons act as nociceptors that detect damage at the organ of Corti. We have developed a behavioral assay for testing avoidance to noxious sounds by rodents, and have preliminary ..
  54. MEMBRANE PROPERTIES OF CELLS COMPRISING THE OHC SYSTEM
    JOSEPH R SANTOS-SACCHI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The organ of Corti is composed of a variety of cell types including sensory, supporting and neural elements...
  55. Adverse Effects of Noise on Hearing: Basic Mechanisms
    Barbara A Bohne; Fiscal Year: 2010
    ..to human health and a long history of noise research, we do not know how excessive noise destroys cells in the organ of Corti (OC)...
  56. CHANGES IN HEARING FOLLOWING DAMAGE TO THE COCHLEAR APEX
    David Moody; Fiscal Year: 1990
    ..noise, application of a cryoprobe to the bony wall of the cochlea, or surgical destruction of a portion of the organ of Corti. These treatments all result in damage to the apical-most portion of the organ of Corti that is primarily ..
  57. Marking hair cell progenitors with BAC transgenics
    Neil Segil; Fiscal Year: 2004
    ..Strategies for hair cell repair that involve either stimulation of quiescent cells in the mature organ of Corti, or which involve transplantation of progenitor cells able to differentiate into hair cells will require ..
  58. Biophysical properties and function of primary auditory neurons
    Radha Kalluri; Fiscal Year: 2013
    ..of rat cochleae that preserve the anatomical and functional connections between the spiral ganglion and organ of Corti. The approach brings together whole-cell patch-clamp recordings, neuronal labeling, morphometric analysis, and ..
  59. DETERMINANTS OF NEURONAL CONNECTIVITY IN THE COCHLEA
    DONNA WHITLON; Fiscal Year: 2005
    ..of nerve fibers make specific and characteristic connections with the inner or outer hair cells in the mouse organ of Corti. Each class of nerve fibers develops during a defined window of time, growing between and along supporting ..
  60. INTERVENTIONS TO PREVENT NOISE INDUCED HEARING LOSS
    JOSEF MILLER; Fiscal Year: 2007
    ..research has also demonstrated a relationship between interventions that prevent free radical formation in the organ of Corti (but not lateral wall) and attenuation of NIHL...
  61. ID OF THE MOUSE DEAFNESS (DN) GENE ON CHROMOSOME 19
    Bronya Keats; Fiscal Year: 2002
    ..The deafness mouse is an autosomal recessive mutant of the curly-tail (CT) stock showing degeneration of the organ of Corti, stria vascularis, and the saccular macula...
  62. FUNCTIONAL GENOMICS OF HEARING
    Zheng Yi Chen; Fiscal Year: 2005
    ..1 targets. The transfection of the organ of Corti cell line will likely identify the targets which may require the co-factors for Brn-3.1 regulation...
  63. REGENERATIVE PHENOMENA IN THE DEVELOPING ORGAN OF CORTI
    HANNA SOBKOWICZ; Fiscal Year: 1999
    ..concerns the morphological and biochemical events that lead o and accompany the regeneration/repair of the organ of Corti in cultures explanted from the neonatal mouse and injured by laser beam...
  64. INNER EAR GAP JUNCTIONS FOR HEARING
    Hong Bo Zhao; Fiscal Year: 2002
    The long-term goal of this project is to investigate how gap junctional coupling in the organ of Corti contributes to normal hearing. Gap junctional coupling is extensive between the cochlear non-sensory cells...
  65. Low Optical Coherence Interferometry for the Cochlea
    Alfred Nuttall; Fiscal Year: 2004
    The major goal in this proposal is to develop and instrument to measure the vibration of the organ of Corti in the living guinea pig...
  66. Electron Tomography of the Outer Hair Cell Lateral Wall
    WILLIAM TRIFFO; Fiscal Year: 2009
    ..SSC) are critical to understanding the transfer of this energy to the OHC and supporting cells of the organ of Corti. To date, most knowledge of lateral wall structure has been limited to extrapolation from 2D studies of ..
  67. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..These tissues supply energy to the organ of Corti in the form of the endocochlear potential (EP)...