cochlea

Summary

Summary: The part of the internal ear that is concerned with hearing. It forms the anterior part of the labyrinth, is conical, and is placed almost horizontally anterior to the vestibule.

Top Publications

  1. pmc Mechanics of the mammalian cochlea
    L Robles
    , Facultad de Medicina, , Universidad de Chile, Santiago, Chile
    Physiol Rev 81:1305-52. 2001
  2. ncbi Math1: an essential gene for the generation of inner ear hair cells
    N A Bermingham
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 284:1837-41. 1999
  3. pmc Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift
    Harrison W Lin
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 12:605-16. 2011
  4. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
  5. pmc BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
  6. pmc Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Dev Biol 328:328-41. 2009
  7. ncbi Salicylate induces tinnitus through activation of cochlear NMDA receptors
    Matthieu J Guitton
    Institut National de la Santé et de la Recherche Médicale UR 254, Laboratoire de Neurobiologie de l Audition Plasticité Synaptique, Faculte de Medecine, Universite de Montpellier 1, 34090 Montpellier, France
    J Neurosci 23:3944-52. 2003
  8. ncbi Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals
    Masahiko Izumikawa
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, MSRB 3, Room 9303, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109 0648, USA
    Nat Med 11:271-6. 2005
  9. pmc Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential
    Philine Wangemann
    Anatomy and Physiology Department, 205 Coles Hall, Kansas State University, Manhattan, 66506, USA
    J Physiol 576:11-21. 2006
  10. pmc Localization of the cochlear amplifier in living sensitive ears
    Tianying Ren
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e20149. 2011

Detail Information

Publications368 found, 100 shown here

  1. pmc Mechanics of the mammalian cochlea
    L Robles
    , Facultad de Medicina, , Universidad de Chile, Santiago, Chile
    Physiol Rev 81:1305-52. 2001
    In mammals, environmental sounds stimulate the auditory receptor, the cochlea, via vibrations of the stapes, the innermost of the middle ear ossicles...
  2. ncbi Math1: an essential gene for the generation of inner ear hair cells
    N A Bermingham
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 284:1837-41. 1999
    The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively...
  3. pmc Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift
    Harrison W Lin
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 12:605-16. 2011
    ..The data cast doubt on prior claims that there is significant neural regeneration and synaptogenesis in the adult cochlea and suggest that denervation of the inner hair cell is an important sequela of "reversible" noise-induced hearing ..
  4. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
    ..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented...
  5. pmc BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
    The mammalian inner ear detects sound with the organ of Corti, an intricately patterned region of the cochlea in which one row of inner hair cells and three rows of outer hair cells are surrounded by specialized supporting cells...
  6. pmc Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Dev Biol 328:328-41. 2009
    ..hair cell-specific miR-183 expression in the three remaining sensory epithelia (posterior crista, utricle, and cochlea) that closely corresponds to the degree of hair cell and sensory epithelium differentiation, and Fgf10 expression ..
  7. ncbi Salicylate induces tinnitus through activation of cochlear NMDA receptors
    Matthieu J Guitton
    Institut National de la Santé et de la Recherche Médicale UR 254, Laboratoire de Neurobiologie de l Audition Plasticité Synaptique, Faculte de Medecine, Universite de Montpellier 1, 34090 Montpellier, France
    J Neurosci 23:3944-52. 2003
    ..Application of NMDA antagonists into the perilymphatic fluids of the cochlea blocked the increase in pole-jumping behavior induced by salicylate, suggesting that salicylate induces tinnitus ..
  8. ncbi Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals
    Masahiko Izumikawa
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, MSRB 3, Room 9303, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109 0648, USA
    Nat Med 11:271-6. 2005
    ..regenerate hair cells is to induce a phenotypic transdifferentiation of nonsensory cells that remain in the deaf cochlea. Here we report that Atoh1, a gene also known as Math1 encoding a basic helix-loop-helix transcription factor and ..
  9. pmc Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential
    Philine Wangemann
    Anatomy and Physiology Department, 205 Coles Hall, Kansas State University, Manhattan, 66506, USA
    J Physiol 576:11-21. 2006
    The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into nerve impulses, depends on the endocochlear potential and requires a highly specialized environment that enables and sustains sensory function...
  10. pmc Localization of the cochlear amplifier in living sensitive ears
    Tianying Ren
    Oregon Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e20149. 2011
    To detect soft sounds, the mammalian cochlea increases its sensitivity by amplifying incoming sounds up to one thousand times...
  11. pmc Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea
    Israt Jahan
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11661. 2010
    ..Neurod1, regulated by both Neurog1 and Atoh1, could be the mediator of this cross-regulation...
  12. ncbi The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006
    ..Both necrotic and apoptotic cell death have been identified in the cochlea. Included in the current review is a brief review of ROS, along with a description of sources of cochlear ROS ..
  13. ncbi Auditory plasticity and hyperactivity following cochlear damage
    R J Salvi
    Hearing Research Lab, University of Buffalo, 215 Parker Hall, Buffalo, NY 14214, USA
    Hear Res 147:261-74. 2000
    This paper will review some of the functional changes that occur in the central auditory pathway after the cochlea is damaged by acoustic overstimulation or by carboplatin, an ototoxic drug that selectively destroys inner hair cells (..
  14. ncbi Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
    Patricia M White
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, California 90057, USA
    Nature 441:984-7. 2006
    ..Here we show that post-mitotic supporting cells purified from the postnatal mouse cochlea retain the ability to divide and trans-differentiate into new hair cells in culture...
  15. pmc Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer
    Samuel P Gubbels
    Department of Otolaryngology, Oregon Hearing Research Center, Portland, Oregon 97239, USA
    Nature 455:537-41. 2008
    Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical impulses that subserve audition. Loss of hair cells and their innervating neurons is the most frequent cause of hearing impairment...
  16. ncbi The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1
    Erwin Van Wijk
    Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 15:751-65. 2006
    ..proteins co-localize with whirlin at the synaptic regions of both photoreceptor cells and outer hair cells in the cochlea. These findings indicate that whirlin is part of a macromolecular PDZ protein scaffold that functions in the ..
  17. ncbi Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
    M Charles Liberman
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 419:300-4. 2002
    ....
  18. pmc Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea
    Renjie Chai
    Department of Otolaryngology Head and Neck Surgery, Stanford University, CA 94305, USA
    J Assoc Res Otolaryngol 12:455-69. 2011
    ..cochlear duct and becomes restricted to tympanic border cells below the basilar membrane in the postnatal cochlea. Both Lgr5 and Axin2 act as Wnt targets in the cochlea because purified Wnt3a promoted and Wnt antagonist ..
  19. pmc Hair cell fate decisions in cochlear development and regeneration
    Douglas A Cotanche
    Laboratory of Cellular and Molecular Hearing Research, Boston University School of Medicine, Boston, MA 02118, USA
    Hear Res 266:18-25. 2010
    ..in understanding the genetic mechanisms that regulate hair cell development in the embryonic avian and mammalian cochlea and regeneration in the mature avian cochlea...
  20. pmc Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo
    Michael C Kelly
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurosci 32:6699-710. 2012
    ..model to direct the expression of Atoh1 in a spatially and temporally specific manner in the postnatal mammalian cochlea to determine the competency of various types of cochlear epithelial cells for hair cell differentiation...
  21. ncbi Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise
    Bo Hua Hu
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 215 Parker Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 166:62-71. 2002
    It has been known for some time that noise-induced outer hair cell (OHC) death in the cochlea continues well after the termination of a noise exposure...
  22. pmc Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 10:e1001231. 2012
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
  23. pmc A protocol for cryoembedding the adult guinea pig cochlea for fluorescence immunohistology
    Bryony Coleman
    The Department of Otolaryngology, University of Melbourne, East Melbourne 3002, Australia The Royal Victorian Eye and Ear Hospital, East Melbourne 3002, Australia
    J Neurosci Methods 176:144-51. 2009
    ..fluorescence of this protein coupled with the innately autofluorescent nature of several structures within the cochlea collectively made the in vivo identification of these transplanted stem cells difficult...
  24. pmc A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea
    Lukasz Kowalik
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, Campus Box 314, The Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Dev Biol 354:221-31. 2011
    ..Our results suggest a role for DNER and PTPζ in hair-cell development and possibly in the specification of tonotopy...
  25. ncbi The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
    ..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...
  26. pmc Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
    T Hasson
    Department of Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 92:9815-9. 1995
    ..We found that myosin VIIa was expressed in cochlea, retina, testis, lung, and kidney...
  27. ncbi Presbycusis
    George A Gates
    Otolaryngology, Head and Neck Surgery, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195 7923, USA
    Lancet 366:1111-20. 2005
    ..Where hearing aids no longer provide benefit, cochlear implantation is the treatment of choice with excellent results even in octogenarians...
  28. ncbi A major gene affecting age-related hearing loss in C57BL/6J mice
    K R Johnson
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Hear Res 114:83-92. 1997
    ..ABR test results and cochlear histopathology of aged progenitors of these congenic lines are presented. Ahl is the first gene causing late-onset, non-syndromic hearing loss that has been reported in the mouse...
  29. ncbi CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells
    Andreas Brandt
    Department of Otolaryngology, Goettingen University Medical School, 37075 Goettingen, Germany
    J Neurosci 23:10832-40. 2003
    ..We conclude that CaV1.3 channels are essential for normal hair cell development and synaptic transmission...
  30. pmc Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea
    Andrea Lelli
    Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908 1392, USA
    J Neurophysiol 101:2961-73. 2009
    ..investigated the functional development of the transduction complex in outer hair cells along the length of mouse cochlea acutely excised between embryonic day 17 (E17) and postnatal day 8 (P8)...
  31. ncbi Hyperactivity in the auditory midbrain after acoustic trauma: dependence on cochlear activity
    W H A M Mulders
    The Auditory Laboratory, Discipline of Physiology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Neuroscience 164:733-46. 2009
    ..whether hyperactivity in the inferior colliculus, once established, is dependent on neural activity in the cochlea. Acoustic trauma (1 h continuous, 10 kHz tone at 124 dB SPL) resulted in a small but permanent, frequency ..
  32. pmc Longitudinal pattern of basilar membrane vibration in the sensitive cochlea
    Tianying Ren
    Oregon Hearing Research Center NRC 04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Proc Natl Acad Sci U S A 99:17101-6. 2002
    ..The vibration propagates from the base of the cochlea to its apex along the cochlear partition...
  33. ncbi Basilar membrane mechanics in the 6-9 kHz region of sensitive chinchilla cochleae
    William S Rhode
    Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Acoust Soc Am 121:2792-804. 2007
    The vibration of the basilar membrane in the 6-9 kHz region in the chinchilla cochlea has been studied using a displacement sensitive interferometer. Displacements of 0.7-1.4 nm at 0 dB sound pressure level have been obtained...
  34. ncbi Gap junction systems in the mammalian cochlea
    T Kikuchi
    Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Brain Res Brain Res Rev 32:163-6. 2000
    ..in the gene for connexin 26 indicate the crucial role that the gene product plays for normal functioning of the cochlea. Excluding sensory cells, most cells in the cochlea are connected via gap junctions and these gap junctions ..
  35. ncbi Math1 regulates development of the sensory epithelium in the mammalian cochlea
    Chad Woods
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Building 35, Bethesda, Maryland 20892, USA
    Nat Neurosci 7:1310-8. 2004
    ..show that absence of Math1 in mice results in a complete disruption of formation of the sensory epithelium of the cochlea, including the development of both hair cells and associated supporting cells...
  36. ncbi K+ cycling and the endocochlear potential
    Philine Wangemann
    Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, 1600 Denison Avenue, Manhattan 66506, USA
    Hear Res 165:1-9. 2002
    Sensory transduction in the cochlea and the vestibular labyrinth depends on the cycling of K+...
  37. pmc MicroRNAs are essential for development and function of inner ear hair cells in vertebrates
    Lilach M Friedman
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7915-20. 2009
    ..This study focuses on miRNAs that are expressed in the mouse cochlea and vestibule, the 2 inner ear compartments...
  38. ncbi An autonomous surgical robot for drilling a cochleostomy: preliminary porcine trial
    C J Coulson
    Department of Otolaryngology, University Hospital Birmingham, Birmingham, UK
    Clin Otolaryngol 33:343-7. 2008
    ..To produce an autonomous drilling robot capable of performing a bony cochleostomy whilst minimising the damage to the underlying cochlear endosteum...
  39. ncbi Impaired cochlear function correlates with the presence of tinnitus and its estimated spectral profile
    Xiang Zhou
    Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA
    Hear Res 277:107-16. 2011
    ..83 ± 0.09, N = 19). Thus, cochlear function is strongly associated with the tinnitus percept and measures of cochlear function using DPOAEs provide additional diagnostic information over perceptual thresholds alone...
  40. ncbi Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings
    R Pujol
    INSERM, Montpellier, France
    Ann N Y Acad Sci 884:249-54. 1999
    ..In the cochlea, excitotoxicity may occur in two pathological conditions: anoxia and noise trauma...
  41. pmc Age-related auditory pathology in the CBA/J mouse
    Su Hua Sha
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 5616, USA
    Hear Res 243:87-94. 2008
    ..At 20-26 months, threshold shifts at 12 and 24 kHz and the accompanying hair cell loss at the base of the cochlea were highly variable with some animals appearing almost normal and others showing large deficits...
  42. ncbi Rbpj regulates development of prosensory cells in the mammalian inner ear
    Norio Yamamoto
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, NIDCD, NIH, Bethesda, MD 20892, USA
    Dev Biol 353:367-79. 2011
    ..prosensory patches in the inner ear with remaining hair cells located predominantly in the extreme apex of the cochlea. However, early markers of prosensory cells are still present in Rbpj-mutants, suggesting that maintenance, ..
  43. pmc In vivo outer hair cell length changes expose the active process in the cochlea
    Dingjun Zha
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e32757. 2012
    ..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification...
  44. pmc Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa
    Martin L Basch
    Department of Neuroscience and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 31:8046-58. 2011
    ..and a shortened cochlear duct, markers of the prosensory domain appear at the normal time and location in the cochlea of RBPjκ mutants...
  45. pmc Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2
    Mohi Ahmed
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 22:377-90. 2012
    ..Our findings demonstrate that direct and cooperative interactions between the Sox2, Six1, and Eya1 proteins coordinate Atoh1 expression to specify hair cell fate...
  46. pmc Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth
    Daisuke Yamauchi
    Cellular Biophysics Laboratory, Dept, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
    BMC Physiol 10:1. 2010
    ..We recently reported the expression of mRNA for a Ca2+-absorptive transport system in primary cultures of semicircular canal duct (SCCD) epithelium...
  47. pmc Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea
    Ruth R Taylor
    Centre for Auditory Research, The Ear Institute, University College London, London, United Kingdom
    PLoS ONE 7:e30577. 2012
    Following the loss of hair cells from the mammalian cochlea, the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues...
  48. ncbi Role of myosin VI in the differentiation of cochlear hair cells
    T Self
    MRC Institute of Hearing Research, University Park, Nottingham, NG7 2RD, United Kingdom
    Dev Biol 214:331-41. 1999
    ..We have investigated the effects of a lack of myosin VI on the development of the sensory hair cells of the cochlea in these mutants...
  49. pmc Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss
    Yun Li
    Center for Molecular Medicine Cologne CMMC, University of Cologne, 50931 Cologne, Germany
    Am J Hum Genet 86:479-84. 2010
    ..1347delG) in exon 1 of TPRN. The function of the encoded protein, taperin, is unknown; yet, partial homology to the actin-caping protein phostensin suggests a role in actin dynamics...
  50. pmc Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation
    Russell L Snyder
    Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
    J Assoc Res Otolaryngol 5:305-22. 2004
    ..Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased...
  51. pmc Acoustic events and "optophonic" cochlear responses induced by pulsed near-infrared laser
    Ingo Ulrik Teudt
    Institute of Audioneurotechnology, Hannover School of Medicine, Hannover, Germany
    IEEE Trans Biomed Eng 58:1648-55. 2011
    Optical stimulation of neural tissue within the cochlea was described as a possible alternative to electrical stimulation...
  52. pmc Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model
    Philine Wangemann
    Anatomy and Physiology Department, Kansas State University, Manhattan, Kansas, USA
    BMC Med 2:30. 2004
    ..We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-)...
  53. pmc Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses
    Leslie D Liberman
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Neurosci 31:801-8. 2011
    ..2010)...
  54. ncbi Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal
    S P Mostafapour
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 426:561-71. 2000
    ..In postnatal day 5 (P5) mice, cochlea removal resulted in 61% neuronal loss in the AVCN...
  55. pmc Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea
    Katherine B Szarama
    Section on Auditory Mechanics, Laboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Development 139:2187-97. 2012
    ..Finally, this study found that the fibroblast growth factor signaling pathway is necessary for the developmental time course of cell surface mechanical properties, in part owing to the effects on microtubule structure...
  56. ncbi Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions
    Helen L May-Simera
    Institute of Child Health, University College London, London WC1N1EH, United Kingdom
    J Comp Neurol 514:174-88. 2009
    ..This study addresses BBS protein expression in the rodent cochlea, to gain a better understanding of its function in vivo...
  57. ncbi A physiological place-frequency map of the cochlea in the CBA/J mouse
    Marcus Müller
    Physiologisches Institut II, J W Goethe Universität Frankfurt, Germany
    Hear Res 202:63-73. 2005
    ..physiologically characterized auditory nerve afferents and determined their peripheral innervation site in the cochlea. From the neuronal characteristic frequency (CF) and the innervation site in the organ of Corti a place-frequency ..
  58. ncbi Pathogenesis of presbycusis in animal models: a review
    Anna R Fetoni
    Institute of Otolaryngology, School of Medicine, Catholic University of Rome, Largo A Gemelli, 8 00168 Rome, Italy
    Exp Gerontol 46:413-25. 2011
    ..Histologically, the aged cochlea shows degeneration of the stria vascularis, the sensorineural epithelium, and neurons of the central auditory ..
  59. ncbi Ageing and hearing loss
    X Z Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    J Pathol 211:188-97. 2007
    ....
  60. pmc Thin-sheet laser imaging microscopy for optical sectioning of thick tissues
    Peter A Santi
    Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
    Biotechniques 46:287-94. 2009
    ..imaging microscope (TSLIM) for nondestructive optical sectioning of organisms and thick tissues such as the mouse cochlea, zebrafish brain/inner ear, and rat brain at a resolution that is comparable to wide-field fluorescence ..
  61. pmc Cochlear efferent innervation and function
    John J Guinan
    Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Curr Opin Otolaryngol Head Neck Surg 18:447-53. 2010
    ..This review covers topics relevant to olivocochlear-efferent anatomy and function for which there are new findings in papers from 2009 to early 2010...
  62. ncbi Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation
    Marcia M Mellado Lagarde
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Curr Biol 18:200-2. 2008
    The remarkable power amplifier [1] of the cochlea boosts low-level and compresses high-level vibrations of the basilar membrane (BM) [2]...
  63. ncbi Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss
    Thomas Schimmang
    Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenreid, Hamburg, Germany
    Development 130:4741-50. 2003
    Members of the neurotrophin gene family and their high-affinity Trk receptors control innervation of the cochlea during embryonic development...
  64. ncbi Apical endocytosis in outer hair cells of the mammalian cochlea
    C B Griesinger
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 20:41-50. 2004
    Outer hair cells (OHCs), the sensory-motor cells of the mammalian cochlea, contain an endocytic tubulovesicular compartment below their apical stereocilia...
  65. ncbi Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea
    Bonnie E Jacques
    Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:3021-9. 2007
    ..These results suggest that PCs might exist in a transient state of differentiation that makes them potential targets for regenerative therapies...
  66. pmc Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Neurosci Res 86:2564-78. 2008
    ..Particularly affected was a subpopulation ensemble of IC neurons with the described unique triad of features...
  67. pmc Membrane cholesterol modulates cochlear electromechanics
    William E Brownell
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Pflugers Arch 461:677-86. 2011
    ..The enhanced electromechanical response reflects an increase in outer hair cell electromotility and may reveal features of cholesterol distribution and trafficking in outer hair cells...
  68. pmc Response of the flat cochlear epithelium to forced expression of Atoh1
    Masahiko Izumikawa
    Kresge Hearing Research Institute, The University of Michigan Medical School, Ann Arbor, MI 48109 5648, USA
    Hear Res 240:52-6. 2008
    ..We then inoculated an adenovirus vector with Atoh1 insert into the scala media of the deafened cochlea. The inoculation resulted in upregulation of Atoh1 in the flat epithelium...
  69. ncbi Inputs from the cochlea and the inferior colliculus converge on olivocochlear neurones
    W H A M Mulders
    The Auditory Laboratory, Discipline of Physiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Stirling Highway, Crawley, WA 6009, Australia
    Hear Res 167:206-13. 2002
    ..Inputs from the contralateral cochlea and the inferior colliculus (IC) have been separately shown to increase activity of MOC neurones...
  70. ncbi Pharmacological inhibition of Notch signaling in the mature guinea pig cochlea
    Ryusuke Hori
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neuroreport 18:1911-4. 2007
    ..These findings indicate that pharmacological inhibition of Notch signaling is a possible strategy for hair cell regeneration in adult auditory epithelia...
  71. ncbi Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
    ..Monitoring MOC effects in humans using OAEs should continue to provide valuable insights into the role of MOC efferents and may also provide clinical benefits...
  72. ncbi Quantification of solute entry into cochlear perilymph through the round window membrane
    A N Salt
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 154:88-97. 2001
    ..The distribution of this ion in the cochlea was monitored without volume disturbance using TMPA-selective microelectrodes sealed into the first and second ..
  73. pmc The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear
    Fumiaki Nin
    Division of Molecular and Cellular Pharmacology, Department of Pharmacology, and Department of Otolaryngology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 105:1751-6. 2008
    ..Because the EP depends on two K(+) diffusion potentials and an electrical barrier in the stria vascularis, interference with any of these elements can interrupt hearing...
  74. ncbi Early elevation of cochlear reactive oxygen species following noise exposure
    K K Ohlemiller
    Research Department, Central Institute for the Deaf, Washington University School of Medicine, St Louis, MO 63110, USA
    Audiol Neurootol 4:229-36. 1999
    ..Persistent cochlear ROS elevation following noise exposure suggests a sustained process of oxidative stress which might be amenable to intervention with chronic antioxidant therapy...
  75. pmc Corticofugal modulation of initial neural processing of sound information from the ipsilateral ear in the mouse
    Xiuping Liu
    Health Science Centre, Hebei University, Baoding, People s Republic of China
    PLoS ONE 5:e14038. 2010
    ..This leads to our hypothesis that corticofugal modulation of initial neural processing of sound information from the contralateral and ipsilateral ears could be equivalent or coordinated at the first sound processing level...
  76. pmc Role of electrode placement as a contributor to variability in cochlear implant outcomes
    Charles C Finley
    Departments of Otolaryngology Head and Neck Surgery and Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Otol Neurotol 29:920-8. 2008
    ..Suboptimal cochlear implant (CI) electrode array placement may reduce presentation of coded information to the central nervous system and, consequently, limit speech recognition...
  77. ncbi Evoked otoacoustic emissions arise by two fundamentally different mechanisms: a taxonomy for mammalian OAEs
    C A Shera
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    J Acoust Soc Am 105:782-98. 1999
    ..of all types are widely assumed to arise by a common mechanism: nonlinear electromechanical distortion within the cochlea. In this view, both stimulus-frequency (SFOAEs) and distortion-product emissions (DPOAEs) arise because ..
  78. ncbi Connexin 26 mutations in hereditary non-syndromic sensorineural deafness
    D P Kelsell
    Academic Department of Dermatology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Nature 387:80-3. 1997
    ..auditory defects that occur as a consequence of either conductive (outer or middle ear) or sensorineuronal (cochlea) abnormalities...
  79. ncbi Measurement of cochlear power gain in the sensitive gerbil ear
    Tianying Ren
    Department of Otolaryngology and Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Commun 2:216. 2011
    ..These results demonstrate experimentally that the cochlea amplifies soft sounds, offering insight into the mechanism responsible for the cochlear sensitivity.
  80. pmc Mitochondrial oxidative damage and apoptosis in age-related hearing loss
    Shinichi Someya
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Mech Ageing Dev 131:480-6. 2010
    ..We also propose that this mechanism may be of general relevance to age-related cell death in long-lived post-mitotic cells of multiple tissues, providing an opportunity for a targeted therapeutic intervention in human aging...
  81. ncbi The demonstration of nitric oxide in cochlear blood vessels in vivo and in vitro: the role of endothelial nitric oxide in venular permeability
    Xiaorui Shi
    Oregon Hearing Research Center NRC04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 172:73-80. 2002
    ..The findings demonstrate the presence of endothelial NO in the cochlear blood vessels and suggest that NO protects cochlear venules against excessive vascular leakage...
  82. pmc Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation
    Amiel A Dror
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 285:21724-35. 2010
    ..We propose a novel mechanism for the accumulation and aggregation of oxalate crystals in the inner ear...
  83. pmc Creatine and tempol attenuate noise-induced hearing loss
    Shujiro B Minami
    Kresge Hearing Research Institute, University of Michigan, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    Brain Res 1148:83-9. 2007
    ..Our results indicate that the maintenance of ATP levels is important in attenuating both temporary and permanent NIHL, while the scavenging of free radicals provides protection from permanent NIHL...
  84. pmc Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 574:677-98. 2006
    ..In the mouse cochlea Tmc1 is expressed in both outer (OHCs) and inner (IHCs) hair cells from early stages of development...
  85. ncbi Nitrogen and oxygen molecules in meningitis-associated labyrinthitis and hearing impairment
    M Klein
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    Infection 36:2-14. 2008
    ..Most likely, bacteria reach the cochlea through the cochlear aquaeduct...
  86. pmc Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear
    L A Everett
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:9727-32. 1999
    ..duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea. This highly discrete expression pattern is unlike that of any other known gene and involves several regions ..
  87. pmc Twinfilin 2 regulates actin filament lengths in cochlear stereocilia
    Anthony W Peng
    Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 29:15083-8. 2009
    ..Here we show that in the mouse cochlea the barbed end capping protein twinfilin 2 is present at the tips of middle and short rows of stereocilia from ..
  88. pmc Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells
    Walter Marcotti
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 548:383-400. 2003
    ..The 4-AP-sensitive current continues to increase after the onset of hearing to form the major part of the mature delayed rectifier, IK,s. By P20 IHCs appear mature in terms of their complement of K+ conductances...
  89. ncbi Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function
    M Knipper
    University of Tubingen, Department of Oto Rhino Laryngology, Tübingen Centre for Hearing Research, Röntgenweg 11, D 72076 Tubingen, Germany
    Development 125:3709-18. 1998
    All cranial nerves, as well as the VIIIth nerve which invades the cochlea, have a proximal end in which myelin is formed by Schwann cells and a distal end which is surrounded by oligodendrocytes...
  90. ncbi Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas
    Norio Yamamoto
    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Mol Med (Berl) 84:37-45. 2006
    ....
  91. ncbi Mechanisms of hair cell death and protection
    Alan G Cheng
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Opin Otolaryngol Head Neck Surg 13:343-8. 2005
    ..Current knowledge of these cell death mechanisms and potential therapeutic targets are discussed in this review...
  92. ncbi The presynaptic function of mouse cochlear inner hair cells during development of hearing
    D Beutner
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg, , Germany
    J Neurosci 21:4593-9. 2001
    ..The observed changes in Ca(2+)-channel expression and synaptic efficacy probably reflected the ongoing synaptogenesis in IHCs that had been described previously in morphological studies...
  93. pmc Shaping the mammalian auditory sensory organ by the planar cell polarity pathway
    Michael Kelly
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Dev Biol 51:535-47. 2007
    ..The vertices of all the "V"-shaped stereocilia point away from the center of the cochlea. The uniform orientation of stereocilia in the organ of Corti manifests a distinctive form of polarity known as ..
  94. pmc Identification and characterization of pannexin expression in the mammalian cochlea
    Xiao Hui Wang
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Comp Neurol 512:336-46. 2009
    ..In this study, expression of pannexins in the mouse and rat cochlea was investigated...
  95. ncbi Threshold and channel interaction in cochlear implant users: evaluation of the tripolar electrode configuration
    Julie Arenberg Bierer
    Department of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd Street, Box 354875, Seattle, Washington 98105 6246, USA
    J Acoust Soc Am 121:1642-53. 2007
    ..The data suggest that tripolar channels with high thresholds may reveal cochlear regions of low neuron survival or poor electrode placement...
  96. pmc Caspase-independent pathways of hair cell death induced by kanamycin in vivo
    H Jiang
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109 0506, USA
    Cell Death Differ 13:20-30. 2006
    ..These results provide a better understanding of the toxic effects of aminoglycosides and are relevant to design protection from aminoglycoside-induced hearing loss...
  97. ncbi Neurogenic regulation of cochlear blood flow occurs along the basilar artery, the anterior inferior cerebellar artery and at branch points of the spiral modiolar artery
    Philine Wangemann
    Cell Physiology Laboratory, Anatomy and Physiology Department, Kansas State University, Manhattan, 66506, USA
    Hear Res 209:91-6. 2005
    The cochlea receives its main blood supply from the basilar artery via the anterior inferior cerebellar artery and the spiral modiolar artery...
  98. ncbi Micro- and nanomechanics of the cochlear outer hair cell
    W E Brownell
    Bobby R Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine and Department of Bioengineering, Rice University, Houston, Texas 77030, USA
    Annu Rev Biomed Eng 3:169-94. 2001
    ..is crucial for the amplification, sharp frequency selectivity, and nonlinearities of the mammalian cochlea. Current modeling efforts based on morphological, physiological, and biophysical observations reveal ..
  99. ncbi Unique expression of connexins in the human cochlea
    Wei Liu
    Department of Otolaryngology, Uppsala University Hospital, Uppsala, Sweden
    Hear Res 250:55-62. 2009
    ..confocal microscopy in decalcified specimen showed that these proteins are widely expressed in the human cochlea. In the lateral wall there was strong antibody co-labeling for Cx26 and Cx30 that support the existence of ..
  100. pmc Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro
    Meagan Barclay
    Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neurosci Lett 478:51-5. 2010
    ..These results indicate that peripherin may interact with other cytoskeletal elements to regulate outgrowth of the peripheral neurites of type II SGN, distinguishing these neurons from the type I SGN innervating the inner hair cells...
  101. ncbi Hemichannel-mediated inositol 1,4,5-trisphosphate (IP3) release in the cochlea: a novel mechanism of IP3 intercellular signaling
    David G Gossman
    Department of Surgery Otolaryngology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0293, USA
    Cell Commun Adhes 15:305-15. 2008
    ..In this study, the mechanism underlying IP(3) intercellular signaling in the cochlea was investigated. A gap junction channel is composed of two hemichannels...

Research Grants77

  1. Hair Cell Regeneration in the Mature Mammalian Cochlea
    Yehoash Raphael; Fiscal Year: 2009
    ..of an adenovirus vector with the Mathl gene insert into the endolymph of the mature pre-deafened guinea pig cochlea, we were able to generate new cochlear hair cells in the organ of Corti...
  2. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2003
    DESCRIPTION (from applicant's abstract): The extracellular matrix, one of the basic constituents of the cochlea, encompasses all of the connective tissue structures of the cochlea (tectorial membrane, spiral limbus, basilar membrane, ..
  3. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    Loud noise is damaging to cells of the cochlea and may be perceived as unpleasant or painful. We aim to clarify the mechanism of this noxious sensation, and ultimately to test for the existence of nociceptor neurons in the cochlea...
  4. Support cell specific expression of regulatable Math-1
    David Poulsen; Fiscal Year: 2006
    Hair cells are the mechanosensory cells of the cochlea and may be lost as a consequence of aging or exposure to ototoxic agents and viral or bacterial pathogens...
  5. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..identified two such molecules, namely the NADPH oxidase isoform, NOX3 (a major source of ROS generation in the cochlea) and transient receptor potential vanilloid 1 channel (implicated in cisplatin ototoxicity)...
  6. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..ability of each method to control glucocorticoid and mineralocorticoid receptor-mediated gene expression in the cochlea. Of particular interest are immune suppression of inflammatory cytokines and related transcription factors ..
  7. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..vertebrates, the mammalian middle ear is unique in its ability to transmit sounds from the external world to the cochlea for frequencies above 10 kHz, the biomechanical basis for sound transmission at high frequencies is poorly ..
  8. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..We and others have shown that the NOX3 isoform of NADPH oxidase is the primary source of ROS in the cochlea which is activated by cisplatin...
  9. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..species (ROS) through the unique cochlear NADPH oxidase isoform, N0X3, the major source of ROS generation in the cochlea. Transplatin also decreased cisplatin-induced intracellular Ca2+ release, induction of stress proteins such as ..
  10. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..Experiments in cochlea-derived cell lines will investigate how transplatin modulates oxidative stress, gene expression, and inflammation ..
  11. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    ..2) Identify a novel set of thyroid hormone regulated genes that affect axonal guidance and synaptogenesis in the cochlea using candidates previously identified by gene expression profiling of Pit1dw and normal cochlea and test the ..
  12. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..death cascade leading to the ultimate loss of roughly half of the neural elements throughout large regions of the cochlea. If generally applicable to the mammalian ear, as there is every reason to believe it will be, the phenomenon of ..
  13. Visualization of ototoxic mitochondrial dysfunction in mammalian hair cells
    Shelley A Batts; Fiscal Year: 2012
    ..would be a tremendous advance for basic researchers seeking to correlate cellular characteristics of the living cochlea with real-time imaging with fluorescent biomarkers of cell function...
  14. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    ..be performed using in vitro cultures of inner ear sensory epithelia, and in vivo studies of noise damage to the cochlea. For identification of HC protectants and transcription factors, innovative high-throughput methods have been ..
  15. Matrix Otopathology
    MICHAEL ANNE NMI GRATTON; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Specialized epithelial and supporting cells in the cochlea are closely associated with extracellular matrices...
  16. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..a strong, rapid recruitment of professional phagocytes in the form of monocytes and macrophages into the mouse cochlea. The present studies will use novel pharmacological methods and knockout mouse strains to examine the role of ..
  17. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2013
    ..the cellular mechanisms of transduction in auditory hair cells and delineate the factors underlying the cochlea's tonotopic organization...
  18. Functional characterization of the Bronx waltzer deafness gene
    Botond Banfi; Fiscal Year: 2013
    ..the identification and characterization of the first deafness gene that regulates essential RNA splicing in the cochlea and vestibular system will lead to the discovery of novel molecular mechanisms, proteins, and protein isoforms ..
  19. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard P Rybak; Fiscal Year: 2012
    ..Cisplatin increases formation of reactive oxygen species (ROS) in the cochlea. A unique isoform of NADPH oxidase, NOX-3, is present in rat cochlea...
  20. USHERIN: STRUCTURAL AND FUNCTIONAL ANALYSIS
    DOMINIC E COSGROVE; Fiscal Year: 2012
    ..proteins function to mediate translocation of proteins in ciliated neuroepithelial cells of the retina and the cochlea. Defects in this process lead to stereo- ciliary defects and photoreceptor cell degeneration...
  21. A cell-specific inducible model of hearing loss
    Albert S Edge; Fiscal Year: 2011
    ..The available methods also result in damage to multiple structures in the cochlea. Our objective is to develop a genetic model in which we can induce the death of specific cell types in the ..
  22. Myosin 15:Genetics, Pathology and Therapeutic Potential
    Sally A Camper; Fiscal Year: 2013
    ..established adenoviral vectors for gene therapy and a database of genes exhibiting differential expression in the cochlea between weaning and adulthood in normal and Myo15 mutant mice...
  23. Determinants of developing efferent synapses in the mammalian cochlea
    ISABELLE CATHERINA ROUX; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the developing mammalian cochlea, the inner hair cells (IHCs) transiently and the outer hair cells (OHCs) permanently receive efferent innervation originating in the auditory brain stem...
  24. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..enormous interest in translation-oriented research aiming at applying exogenous neurotrophin(s) to the human cochlea to promote the survival of residual SG neurons in the cochlea of severe sensorineural hearing loss patients...
  25. Mechanics of Inner Ear Hair Bundles
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2012
    ..The overall goal is to understand how sound is coupled to individual stereocilia within hair bundles of mammalian cochlea. Previous experiments have been limited by poor stimulus-probe coupling to bundles, which produces stimuli that ..
  26. Novel Approaches for Prevention and Treatment of Noise Induced Hearing loss
    Debashree Mukherjea; Fiscal Year: 2013
    ..indicate increased reactive oxygen species (ROS) generation and increased inflammatory mediators in the cochlea after noise trauma...
  27. Mitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing Loss
    Shinichi Someya; Fiscal Year: 2013
    ..antioxidant enzyme catalase localized to mitochondria increases lifespan (16), reduces oxidative damage in the cochlea, and delays the onset of AHL in mice (10)...
  28. Mechanisms of Sensory Regeneration
    Mark Warchol; Fiscal Year: 2013
    ..The cochlea and vestibular organs contain large numbers of macrophages, but the function of those cells within the ear is ..
  29. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
    ..occur long after hair cells have died, we ask, in Aim 2, whether other post-deafening degenerative changes in the cochlea can account for SGN death, focusing on the death of glial cells, peripheral process degeneration, and loss of NT-..
  30. PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
    Jochen Schacht; Fiscal Year: 2013
    ..Much of what we know about cell death, survival and protection in the cochlea has come from extensive research into aminoglycoside ototoxicity...
  31. Occupational exposure to manganese and noise potentiate hearing loss
    Richard J Salvi; Fiscal Year: 2013
    ..Since Mn has been reported to accumulate in the inner ear (cochlea) following acute treatment, we hypothesize that it has the potential to damage the sensory hair cells that ..
  32. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..Persons who lack a functional auditory nerve cannot benefit form cochlea implants, but some hearing can be restored by a prosthesis implanted in or on the cochlea nucleus...
  33. Genetic Dissection of Auditory Circuit Assembly
    Lisa V Goodrich; Fiscal Year: 2013
    6. Project Summary/Abstract Hearing begins with the detection of sound by hair cells in the cochlea of the inner ear...
  34. Deciphering the Usher I protein interactome using a genetic approach
    Qing Y Zheng; Fiscal Year: 2013
    ..Residual hair cells present in the cochlea could promote the survival of spiral ganglion neurons by release of neurotrophic substances...
  35. Gene-Expression Patterns During Hair-Cell Regeneration
    ALBERT JAMES HUDSPETH; Fiscal Year: 2010
    ..to the alleviation of deafness is the restoration of normal hearing by regeneration of hair cells in the human cochlea. We wish to determine the particular genes whose activation underlies the renewal of hair cells in species whose ..
  36. PCBs, PBDEs, Hearing Loss & Attention/Impulsivity: Mechanistic Studies in Animals
    Susan L Schantz; Fiscal Year: 2010
    ..Histological examinations of the cochlea will confirm whether hearing deficits are due to outer hair cell damage...
  37. Trophic interactions in developing and adult inner ear
    Gabriel Corfas; Fiscal Year: 2013
    ..of erbB signaling in supporting cells leads to neuronal degeneration, preceded by a specific loss of NT3 in the cochlea and BDNF in the vestibular organs, at a time when these neurotrophins (NTs) are expressed primarily by supporting ..
  38. Regulation of hair cell determination by the Wnt/Calcium signaling pathway
    Alain Dabdoub; Fiscal Year: 2012
    ..within structures comprised of highly ordered cellular patterns such as the sensory epithelium of the mammalian cochlea. Within the organ of Corti, a single row of inner hair cells and three rows of outer hair cells extend along the ..
  39. Effectiveness of Therapy via Telemedicine following Cochlear Implants
    Anu Sharma; Fiscal Year: 2013
    ..The implant stimulates the 8th cranial nerve, allowing auditory input to circumvent damaged hair cells in the cochlea, and hence to stimulate the auditory cortex...
  40. Morphogenesis of the organ of Corti
    Ping Chen; Fiscal Year: 2013
    ..Invariably, the vertices of "V"-shaped stereocilia of all the hair cells point to the periphery of the cochlea, displaying a polarity that is parallel to the sensory epithelium and known as planar cell polarity (PCP)...
  41. Molecular roles in active and passive mechanics in cochlear hair bundles
    ANTHONY WEI PENG; Fiscal Year: 2013
    ..New experiments in the cochlea will be performed using these novel MEMS devices to characterize mechanics of the hair bundle when modifying ..
  42. Heat Shock Protein-Induced Protection Against Cisplatin-Induced Hair Cell Death
    TIFFANY GRAY BAKER; Fiscal Year: 2013
    ..One of these Hsps, Hsp32, has been shown to inhibit cisplatin-induced hair cell death in neonatal rat cochlea in vitro (Kim et al. 2006)...
  43. Gene Expression in Rat Cochlea Following Loss of Hair Cells
    Erin Bailey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human hearing loss is most often attributed to the loss of hair cells in the cochlea. Hair cells function as auditory receptors and are the sole afferent input to the spiral ganglion neurons (SGNs)...
  44. Sensory cell fate specification in the inner ear
    Douglas J Epstein; Fiscal Year: 2012
    ..to produce the required patterns of growth and differentiation necessary for the formation of the vestibulum and cochlea, the two inner ear organs responsible for sensing, balance and sound, respectively...
  45. Regulation of outer hair cell electromotility and noise-induced hearing loss
    Gregory I Frolenkov; Fiscal Year: 2013
    ..The goal of this project is to determine how TRPA1 channels participate in the protection of the cochlea from over- stimulation...
  46. Regulation of cochlea hair cell differentiation by the Lin28b/let-7 axis
    Erin Golden; Fiscal Year: 2013
    ..the molecular mechanisms regulating the initiation of hair cell differentiation in the developing mammalian cochlea. Our lab has found the heterochronic Lin28b/let-7 axis to be expressed during cochlea differentiation, ..
  47. Fluid transport in inner ear development
    A PHILINE WANGEMANN; Fiscal Year: 2013
    ..Studies in mouse have demonstrated that pendrin is a Cl-/HCO3- exchanger in the cochlea, vestibular labyrinth and the endolymphatic sac...
  48. THE ROLES OF ESPINS IN HAIR CELL STEREOCILIA
    James R Bartles; Fiscal Year: 2012
    ..stereocilium dimensions according to position in the mechanosensory hair bundle and hair cell position within the cochlea or vestibular system...
  49. Potassium Homeostasis in the Inner Ear
    Ebenezer N Yamoah; Fiscal Year: 2013
    ..of the specific functions of individual K+ and Cl- channels, as well as the different cell types in the walls of the cochlea, and how they work together to mediate EP and trans-epithelial ion transport processes in vivo.
  50. PRESERVATION OF TIMING IN PLASTIC AUDITORY PATHWAYS
    HENRIQUE PRADO VON GERSDORFF; Fiscal Year: 2013
    ..so it will further our basic understanding of how to excite different auditory nerve fibers artificially with cochlea implants (devices that can partially restore hearing by bypassing the damaged hair cells to directly stimulate ..
  51. Hair Cell Regeneration: Molecular Regulation
    Jennifer S Stone; Fiscal Year: 2013
    ..Here, we propose to extend these studies into other regions of the inner ear, including the cochlea. We employed a new transgenic mouse (Pou4f3DTR) in which selective hair cell loss can be induced by ..
  52. DYNAMIC INTERATION AMONG PROTEINS IN HAIR CELLS
    Jing Zheng; Fiscal Year: 2013
    ..CEACAM16 is a cell adhesion protein that we discovered in the cochlea. In AIM I, we propose to investigate functional roles of CEACAM16 for maintaining the tectorial membrane ..
  53. Pluripotent Stem Cell Technology for the Study and treatment of Human hearing los
    Samuel Paul Gubbels; Fiscal Year: 2013
    ..In addition, stem cells survive following transplantation into the rdent cochlea. These two findings have fueled enthusiasm for exploring the use of stem cells as a means to improve our ..
  54. Effects of Sensorineural Hearing Loss on Robust Speech Coding
    Michael G Heinz; Fiscal Year: 2013
    ..narrowband cochlear filtering limits the ability to isolate fine-structure and envelope at the output of the cochlea. Neural cross-correlation coefficients will quantify directly the effects of sensorineural loss on the fidelity ..
  55. A Middle Ear Twist: Imaging, Physiology & Biomechanics
    RYAN PATRICK JACKSON; Fiscal Year: 2010
    ..the biomechanics that enable high-frequency (JHF) sound, greater than 10 kHz, to be transduced from middle-ear to cochlea in a group of terrestrial mammals...
  56. DEVELOPMENT OF EXCITATION IN HAIR CELLS
    BERND H SOKOLOWSKI; Fiscal Year: 2013
    ..The specific aims of the proposal are to (1) validate newly-discovered BKAPs from the adult cochlea, by measuring BK expression, when silencing its partners, (2) determine how specific BKAPs alter the biophysical ..
  57. Adverse Effects of Noise on Hearing: Basic Mechanisms
    Barbara A Bohne; Fiscal Year: 2010
    ..and dying hair cells will be made and cells with trypan-blue-stained nuclei will be counted through- out the cochlea. We will compare changes in auditory function to losses of hair cells and other types of structural damage...
  58. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..goal of this project is to understand how descending neural systems modify information processing in the cochlea and cochlear nucleus...
  59. PHARMACOLOGY OF NEUROTRANSMITTERS IN HAIR CELL ORGANS
    William F Sewell; Fiscal Year: 2010
    Our long-term goals are centered on understanding synaptic transmission and neurotransmitters in the cochlea. In this project period, we will focus on dynamic regulation of afferent transmission and its role in achieving some of the ..
  60. Activation of inner ear stem cells by B-catenin
    Fuxin Shi; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Sensory hair cells in the cochlea are responsible for sound detection but these cells can be damaged or lost by a variety of factors leading to ..
  61. Zeiss LSM 710 confocal microscope
    Jaime Grutzendler; Fiscal Year: 2010
    ..Additional applications include live imaging of retina and cochlea organotypic preparations as well as brain slices...
  62. Perivascular macrophages endothelial interactions at the blood labyrinth barrier
    Xiao Rui Shi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The blood-labyrinth barrier (BLB) in the stria vascularis of the cochlea maintains endocochlear potential, ion transport, and fluid balance in the inner ear...
  63. The role of MafB in auditory synapse development
    Wei Ming Yu; Fiscal Year: 2013
    ..in MafBOE, suggesting that MafB is required for normal formation of synapses between hair cells and SGNs in the cochlea. These effects may depend in part on the neuronal chemokine CCL21, which activates microglia in other regions of ..
  64. Pediatric Percutaneous Cochlear Implantation Clinical Validation &Implementation
    Robert F Labadie; Fiscal Year: 2012
    Project Summary/Abstract: Access to the inner ear, specifically the cochlea, is currently required for cochlear implant (CI) surgery, in which an electrode array is used to stimulate the auditory nerve and allow deaf people to hear...
  65. Cholesterol Homeostasis in Auditory Function
    MICHELLE LYNN SEYMOUR; Fiscal Year: 2013
    ..a link between hypercholesterolemia and sensorineural hearing loss that implicates pathologies affecting the cochlea, auditory nerve and/or central auditory pathways, fundamental information is lacking to explain this relationship...
  66. Hearing circadian rhythms.
    Barbara Canlon; Fiscal Year: 2013
    ..The hypothesis to be tested is that the cochlea has an intrinsic circadian clock that modulates the sensitivity of the auditory system to noise trauma...
  67. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    ..could influence ototoxic sensitivity to loop diuretics include; glucose utilization/energy metabolism in the cochlea (Aim 1) drug distribution and an immature blood-labyrinth barrier (Aim 2) hepatic metabolism of xenobiotics (Aim ..
  68. Ear Biomechanics for Restoration of Hearing
    RONG GAN; Fiscal Year: 2009
    ..human ear affect acoustic-mechanical transmission through the external ear canal and middle ear to inner ear (or cochlea) in normal, pathological and reconstructed ears...
  69. DEAFNESS AND OSSIFICATION IN LABYRINTHITIS OSSIFICANS
    Hilary Brodie; Fiscal Year: 2004
    ..Abstract) Labyrinthitis ossificans (LO) is the growth of pathologic new bone within the lumen of the cochlea. It is multifactorial in origin and may result in deafness...
  70. Transduction of the Mouse Auditory System with AAV
    DIANA LURIE; Fiscal Year: 2003
    ..Therefore, it is not surprising that AAV-2 has not been a successful vector for gene transfer within the cochlea. We propose to systematically evaluate transgene delivery to the mouse cochlea and spiral ganglia using AAV ..
  71. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
    ..In the developing cochlea, bursts of action potentials occur in afferent spiral ganglion neurons prior to the onset of hearing, activity ..
  72. Cochlear Therapy through Magnetic Targeted Drug Delivery
    Richard Kopke; Fiscal Year: 2009
    ..A promising gene therapy for hair cell regeneration from non-sensory cells that remain in damaged cochlea has been accomplished in mammals for the first time...
  73. Postsynaptic Activity of Type II Cochlear Afferents
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The cochlea contains two types of primary afferent neurons, the Type I and Type II spiral ganglion neurons...
  74. Effects of aging on evoked otoacoustic emissions in the common marmoset
    Rama Ratnam; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The broad goal of this project is to determine the effects of aging on the cochlea of a new world primate, the common marmoset (Callithrix jacchus)...
  75. CHANGES IN HEARING FOLLOWING DAMAGE TO THE COCHLEAR APEX
    David Moody; Fiscal Year: 1990
    ..animal will be lesioned by exposure to low-frequency noise, application of a cryoprobe to the bony wall of the cochlea, or surgical destruction of a portion of the organ of Corti...
  76. RECOVERY OF STRUCTURE AND FUNCTION AFTER COCHLEAR DAMAGE
    Richard Salvi; Fiscal Year: 1999
    ..about the biological mechanisms that regulate or limit the recovery of auditory function at the level of the cochlea. The overall goal of this project is to determine what functional deficits are present in the neural output of ..
  77. Tomographic Imaging of Cochlear Micromechanical Motions
    DENNIS FREEMAN; Fiscal Year: 2006
    The cochlea is a remarkable sensor: a living cochlea can reliably detect sounds that cause motions of the stapes on the order of picometers, is capable of high-quality frequency analysis (Q10dB > 600), and compresses the large dynamic ..