pharynx

Summary

Summary: A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).

Top Publications

  1. pmc The genetics of feeding in Caenorhabditis elegans
    L Avery
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Genetics 133:897-917. 1993
  2. ncbi Pharyngeal mucosal pressure and perfusion: a fiberoptic evaluation of the posterior pharynx in anesthetized adult patients with a modified cuffed oropharyngeal airway
    J Brimacombe
    Department of Anesthesia and Intensive Care, Cairns Base Hospital, Australia
    Anesthesiology 91:1661-5. 1999
  3. pmc The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans
    W Robert Shaw
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Genetics 185:897-905. 2010
  4. pmc Is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit?
    Stephan Harbarth
    J Clin Microbiol 45:1072-3. 2007
  5. pmc Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
    Young jai You
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:237-45. 2006
  6. pmc eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx
    James P McKay
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genetics 166:161-9. 2004
  7. pmc Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness
    Ann R Falsey
    University of Rochestera and Rochester General Hospital, b Rochester, New York, USA
    J Clin Microbiol 50:21-4. 2012
  8. pmc Influence of gender and age on upper-airway length during development
    Ohad Ronen
    Department of Otolaryngology, Head and Neck Surgery, Carmel Medical Center, Haifa, Israel
    Pediatrics 120:e1028-34. 2007
  9. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011
  10. pmc Laminin is required to orient epithelial polarity in the C. elegans pharynx
    Jeffrey P Rasmussen
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 139:2050-60. 2012

Detail Information

Publications324 found, 100 shown here

  1. pmc The genetics of feeding in Caenorhabditis elegans
    L Avery
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Genetics 133:897-917. 1993
    The pharynx of Caenorhabditis elegans is a nearly self-contained neuromuscular organ responsible for feeding...
  2. ncbi Pharyngeal mucosal pressure and perfusion: a fiberoptic evaluation of the posterior pharynx in anesthetized adult patients with a modified cuffed oropharyngeal airway
    J Brimacombe
    Department of Anesthesia and Intensive Care, Cairns Base Hospital, Australia
    Anesthesiology 91:1661-5. 1999
    ..the relation between pharyngeal mucosal perfusion and directly measured mucosal pressure (MP) in the posterior pharynx using a fiberoptic technique with a modified cuffed oropharyngeal airway (COPA)...
  3. pmc The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans
    W Robert Shaw
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Genetics 185:897-905. 2010
    ..mir-51 family mutants display a highly penetrant pharynx unattached (Pun) phenotype, where the pharyngeal muscle, the food pump of C...
  4. pmc Is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit?
    Stephan Harbarth
    J Clin Microbiol 45:1072-3. 2007
  5. pmc Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
    Young jai You
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:237-45. 2006
    ..We suggest that, during starvation, the muscarinic pathway to MAPK is activated to change the pharyngeal muscle physiology to enhance ingestion of food when food becomes available...
  6. pmc eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx
    James P McKay
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genetics 166:161-9. 2004
    Mutations in eat-2 and eat-18 cause the same defect in C. elegans feeding behavior: the pharynx is unable to pump rapidly in the presence of food...
  7. pmc Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness
    Ann R Falsey
    University of Rochestera and Rochester General Hospital, b Rochester, New York, USA
    J Clin Microbiol 50:21-4. 2012
    ..Further studies designed to adapt the use of sputum samples for commercial RT-PCR respiratory virus assays are needed...
  8. pmc Influence of gender and age on upper-airway length during development
    Ohad Ronen
    Department of Otolaryngology, Head and Neck Surgery, Carmel Medical Center, Haifa, Israel
    Pediatrics 120:e1028-34. 2007
    ....
  9. pmc Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
    Patrick R Shea
    The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Emerg Infect Dis 17:2010-7. 2011
    ..We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease. These findings about the epidemiology of GAS are potentially useful for vaccine research...
  10. pmc Laminin is required to orient epithelial polarity in the C. elegans pharynx
    Jeffrey P Rasmussen
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 139:2050-60. 2012
    ..The C. elegans pharynx, which is an epithelial tube in which cells polarize around a central lumen, provides a simple system with which ..
  11. ncbi Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx
    G V S Rao
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:1441-52. 2003
    ..have demonstrated that the mouse lung can be exposed to soluble antigens by aspiration of these antigens from the pharynx. This simple technique avoids the trauma associated with intratracheal instillation...
  12. ncbi The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively
    Yinhua Zhang
    New England Biolabs Inc, 240 County Road, Ipswich, MA 01938, USA
    Dev Biol 285:330-9. 2005
    ..Knocking down chs-2 by RNAi caused a defect in the pharynx and led to L1 larval arrest, indicating that chitin is involved in the development and function of the pharynx.
  13. pmc pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans
    M A Horner
    Huntsman Cancer Institute, Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 USA
    Genes Dev 12:1947-52. 1998
    ..Here we show that the pha-4 locus establishes organ identity for the Caenorhabditis elegans pharynx. In pha-4 mutants, pharyngeal cells are transformed into ectoderm...
  14. ncbi The influence of chemical gustatory stimuli and oral anaesthesia on healthy human pharyngeal swallowing
    Carolyn Chee
    Manchester Medical School, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Chem Senses 30:393-400. 2005
    ..By 15 min all measures except sensory thresholds had returned to baseline values. Thus, swallowing function is highly influenced by chemosensory input, providing insight into how oral sensation regulates pharyngeal swallowing...
  15. ncbi Early morphogenesis of the Caenorhabditis elegans pharynx
    M F Portereiko
    Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    Dev Biol 233:482-94. 2001
    ..The embryonic pharynx develops from a ball of cells into a linear tube connected anteriorly to the buccal cavity and posteriorly to the ..
  16. pmc Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan
    David K Chow
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program NIA IRP, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 41:252-60. 2006
    ..Here, we report that contraction-related injury may significantly promote the progression of sarcopenia in the pharynx of the nematode, Caenorhabditis elegans, a model of aging in non-regenerative tissues...
  17. pmc Evaluation of different clinical sample types in diagnosis of human enterovirus 71-associated hand-foot-and-mouth disease
    Mong How Ooi
    Department of Paediatrics, Sibu Hospital, Ulu Oya Road, 96000 Sibu, Sarawak, Malaysia
    J Clin Microbiol 45:1858-66. 2007
    ..Vesicle swabs give a high diagnostic yield, with the added advantage of being from a sterile site...
  18. pmc The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans
    Robert Steven
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genes Dev 19:2016-29. 2005
    ..UNC-73 D1 and D2 appear to function redundantly in pharynx muscle to regulate the rate and strength of pharynx pumping, and in the HSN neurons and vulval muscles to control ..
  19. ncbi Epimorphic regeneration of the distal part of the planarian pharynx
    H Ito
    Department of Life Science, Faculty of Science, Himeji Institute of Technology, Akou-gun, Hyogo, Japan
    Dev Genes Evol 211:2-9. 2001
    ..However, the pharynx is able to regenerate after the amputation of its distal part, in spite of a lack of neoblasts in the pharynx...
  20. ncbi The utility of rapid antigen detection testing for the diagnosis of streptococcal pharyngitis in low-resource settings
    Anne W Rimoin
    Department of Epidemiology, UCLA School of Public Health, 650 Charles E Young Drive S, CHS 41 275, Los Angeles, CA 90095, USA
    Int J Infect Dis 14:e1048-53. 2010
    ..To evaluate the utility of rapid antigen detection testing (RADT) for the diagnosis of group A streptococcal (GAS) pharyngitis in pediatric outpatient clinics in four countries with varied socio-economic and geographic profiles...
  21. ncbi Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx of Caenorhabditis elegans
    Mandy Kosel
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Biochem J 435:689-700. 2011
    ..nematode worms carrying a pCYP33E2::GFP reporter construct, we found that CYP33E2 is exclusively expressed in the pharynx, where it is predominantly localized in the marginal cells...
  22. ncbi Lymphogranuloma venereum detected from the pharynx in four London men who have sex with men
    O Dosekun
    Guy s and St Thomas NHS Trust, Camden Provider Services, London, UK
    Int J STD AIDS 24:495-6. 2013
    ..We report four cases where LGV-associated CT DNA was detected from the pharynx in MSM, demonstrating that nucleic acid amplification testing (NAAT) can be used for detecting and typing ..
  23. pmc Re: is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit?
    Caroline Marshall
    J Clin Microbiol 45:3855. 2007
  24. pmc Radiation dose-volume effects in the larynx and pharynx
    Tiziana Rancati
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 76:S64-9. 2010
    ..For late dysphagia, a major issue is accurate definition and uncertainty of the relevant anatomical structures. These and other issues are discussed...
  25. ncbi Screening for Staphylococcus aureus carriage in pregnancy: usefulness of novel sampling and culture strategies
    Janet I Andrews
    Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, IA, USA
    Am J Obstet Gynecol 201:396.e1-5. 2009
    ..The purpose of this study was to determine the most sensitive strategy for the detection of Staphylococcus aureus among pregnant women and newborn infants...
  26. ncbi Development of Caenorhabditis elegans pharynx, with emphasis on its nervous system
    Marc Pilon
    Lundberg Laboratory, Chalmers University, Goteborg S 405 30, Sweden
    Acta Pharmacol Sin 26:396-404. 2005
    The Caenorhabditis elegans pharynx is a neuromuscular tube of which the function is to pump and crush bacteria, and inject them into the intestine...
  27. ncbi Nonacid reflux episodes reaching the pharynx are important factors associated with cough
    Neil Patterson
    Department of Medicine, Royal Hospitals, Grosvenor Road, Belfast, UK
    J Clin Gastroenterol 43:414-9. 2009
    ..To date most studies have focused on acid reflux measured by pH below the upper esophageal sphincter (UES). The aim of this study was to assess the relationship between cough and reflux through the UES into the pharynx.
  28. ncbi The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function
    Gudrun Aspöck
    Division of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 130:3369-78. 2003
    ..nuclei of one type of small muscle cell, one type of epithelial cell, and three types of neurons in the anterior pharynx in the head. We have generated a deletion allele of ceh-2 that removes the homeobox...
  29. ncbi A protocol describing pharynx counts and a review of other assays of apoptotic cell death in the nematode worm Caenorhabditis elegans
    Hillel T Schwartz
    MIT Department of Biology, Howard Hughes Medical Institute, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Protoc 2:705-14. 2007
    ..Detailed instructions are provided for one standard method--the counting of extra cells of the anterior pharynx--a quantitative technique that can be used to detect even very subtle alterations in the progression of apoptotic ..
  30. ncbi pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus
    Catarina Mörck
    Lundberg Laboratory, Chalmers University, Goteborg S 405 30, Sweden
    Dev Biol 272:403-18. 2004
    ..The present report is the first to examine the expression and function of an invertebrate Hex homolog, that is, the C. elegans pha-2 gene...
  31. ncbi Food wrapping with the postpharyngeal gland secretion by females of the European beewolf Philanthus triangulum
    Gudrun Herzner
    Department of Animal Ecology and Tropical Biology, University of Wurzburg, Biozentrum, Am Hubland, D 97074, Wurzburg, Germany
    J Chem Ecol 33:849-59. 2007
    ..We discuss our findings with regard to other possible mechanisms of the postpharyngeal gland secretion against fungal growth...
  32. ncbi Which anatomical sites should be sampled for screening of methicillin-resistant Staphylococcus aureus carriage by culture or by rapid PCR test?
    L Senn
    Service of Hospital Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Microbiol Infect 18:E31-3. 2012
    ..In conclusion, neither by culture nor by rapid PCR test is nose sampling alone sufficient for MRSA detection. Additional anatomical sites should include at least the groin and throat...
  33. pmc The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function
    Ryan B Smit
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    PLoS Genet 4:e1000222. 2008
    The Caenorhabditis elegans pharynx (or foregut) functions as a pump that draws in food (bacteria) from the environment. While the "organ identity factor" PHA-4 is critical for formation of the C...
  34. pmc Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans
    Andrew Ferrier
    Biology Department, Lake Forest College, Lake Forest, Illinois, United States of America
    PLoS ONE 6:e26594. 2011
    ..distinctive pharyngeal phenotypes in worms surviving to the L1 larval stage, with phenotypes ranging from short pharynx, unattached pharynx, missing cells, asymmetric morphology, and non-adherent pharynx cells...
  35. pmc Sonographic measurement of lateral parapharyngeal wall thickness in patients with obstructive sleep apnea
    Kin Hung Liu
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Sleep 30:1503-8. 2007
    ..We also investigated the association between sonographic measurement of LPW thickness and apnea-hypopnea index (AHI)...
  36. ncbi Magnetic resonance imaging of the pharynx in OSA patients and healthy subjects
    M A Ciscar
    Service of Pneumology, Hospital General Universitario de Valencia, Spain
    Eur Respir J 17:79-86. 2001
    ..This suggests that apnoeic patients have a more collapsible velopharynx, this being the main mechanism of obstruction...
  37. ncbi Particle retention and flow in the pharynx of the enteropneust worm Harrimania planktophilus: the filter-feeding pharynx may have evolved before the chordates
    Christopher B Cameron
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Biol Bull 202:192-200. 2002
    ..9 microm. Food coloring entered the mouth and was pumped through the pharynx at a rate of 0.5-2.0 mm/s. There is no evidence of an endostyle or mucus-net capture mechanism in H...
  38. pmc Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling
    Eon Joo Park
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 133:2419-33. 2006
    ..These findings provide a novel insight into how the formation and remodeling of primary and anterior heart field-derived structures rely on Fgf8 signals from discrete temporospatial domains...
  39. ncbi Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native receptor
    D J Pemberton
    Centre for Neuroscience, University of Southampton, Bassett Crescent East, Southampton UK
    Mol Pharmacol 59:1037-43. 2001
    ..Here, we have used a quantitative pharmacological approach and intracellular recording techniques of C. elegans pharynx to characterize them...
  40. pmc The GAR-3 muscarinic receptor cooperates with calcium signals to regulate muscle contraction in the Caenorhabditis elegans pharynx
    Katherine A Steger
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genetics 167:633-43. 2004
    ..Because the effects of GAR-3 signaling on membrane depolarization and muscle contraction can be separated, we conclude that GAR-3 regulates multiple calcium-dependent processes in the C. elegans pharyngeal muscle...
  41. ncbi How the worm got its pharynx: phylogeny, classification and Bayesian assessment of character evolution in Acoela
    Ulf Jondelius
    Department of Invertebrate Zoology, Swedish Museum of Natural History, Stockholm, Sweden
    Syst Biol 60:845-71. 2011
    ..Convolutidae, including several "model" acoels, is most divergent. Finally, we present a phylogenetic classification of Acoela down to the family level where six previous family level taxa are synonymized...
  42. pmc The in vitro interaction of Streptococcus pyogenes with human pharyngeal cells induces a phage-encoded extracellular DNase
    Thomas B Broudy
    Department of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021, USA
    Infect Immun 70:2805-11. 2002
    ..Finally, we speculate on the induction of phage-encoded DNase (Spd1) enhancing the fitness of both bacteria and phage...
  43. ncbi Relationship between cephalometric characteristics and obstructive sites in obstructive sleep apnea syndrome
    Un Bong Baik
    Department of Orthodontics, Tohoku University School of Dentistry, Sendai, Japan
    Angle Orthod 72:124-34. 2002
    ..All of the groups shared the characteristic of having an inferior position of the hyoid bone. Based on the results of the current study, we conclude that many features of OSAS are specifically related to each obstructive type of OSAS...
  44. pmc Hyoid apparatus and pharynx in the lion (Panthera leo), jaguar (Panthera onca), tiger (Panthera tigris), cheetah (Acinonyxjubatus) and domestic cat (Felis silvestris f. catus)
    G E Weissengruber
    Institute of Anatomy, University of Veterinary Medicine, Vienna, Austria
    J Anat 201:195-209. 2002
    Structures of the hyoid apparatus, the pharynx and their topographical positions in the lion, tiger, jaguar, cheetah and domestic cat were described in order to determine morphological differences between species or subfamilies of the ..
  45. ncbi The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx
    Z D Zhang
    Pirbright Laboratory, Institute for Animal Health, World Reference Laboratory for Foot and Mouth Disease, Ash Road, Pirbright, Surrey, GU24 0NF, UK
    J Comp Pathol 124:89-94. 2001
    ..TSA) provided the first direct evidence that FMDV RNA is localized within the epithelial cells of the soft palate and pharynx during persistent infection, indicating that these cells remain persistently infected after contact with FMDV.
  46. ncbi Heavy snorer's disease: a progressive local neuropathy
    D Friberg
    Department of Otorhinolaryngology, Huddinge University Hospital, Sweden
    Acta Otolaryngol 119:925-33. 1999
    ..These lesions may cause the collapse of upper airways in OSAS. Since it is not known which "heavy snorer" will develop OSAS, early effective prevention and or treatment of snoring is called for...
  47. ncbi The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle
    P G Okkema
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210
    Development 120:2175-86. 1994
    ..Expression continues throughout embryonic and larval development. This expression pattern suggests CEH-22 plays a key role in pharyngeal muscle-specific activity of the myo-2 enhancer...
  48. pmc Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development
    Timothy L Macatee
    Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 130:6361-74. 2003
    ....
  49. ncbi Impact of rapid diagnosis on management of adults hospitalized with influenza
    Ann R Falsey
    Departments of Medicine, Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    Arch Intern Med 167:354-60. 2007
    ..We compared the clinical management of patients with influenza whose rapid antigen test result was positive (Ag+) with the management of those whose rapid antigen test result was negative or the test was not performed (Ag0)...
  50. pmc Epidemiology of Streptococcus dysgalactiae subsp. equisimilis in tropical communities, Northern Australia
    Malcolm McDonald
    Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia
    Emerg Infect Dis 13:1694-700. 2007
    ..These communities already have high levels of streptococcal and poststreptococcal disease. GCS/GGS may increase in importance as it acquires key virulence factors from GAS by lateral gene transfer...
  51. ncbi Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine, and FMRFamide-like neuropeptides
    C M Rogers
    Centre for Neuroscience, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton S016 7PX, United Kingdom
    J Neurobiol 49:235-44. 2001
    ..elegans pharynx. AF1 (KNEFIRFamide), AF2 (KHEYLRFamide), AF8 (KSAYMRFamide), and GAKFIRFamide (encoded by the C...
  52. ncbi Effectiveness of clinical guidelines for the presumptive treatment of streptococcal pharyngitis in Egyptian children
    M C Steinhoff
    Department of International Health, School of Hygiene and Public Health, Baltimore MD, USA
    Lancet 350:918-21. 1997
    ..We evaluated the WHO Acute Respiratory Infection guideline in a large urban paediatric clinic in Egypt...
  53. pmc Detection of influenza A viruses from different species by PCR amplification of conserved sequences in the matrix gene
    R A Fouchier
    National Influenza Center and Department of Virology, Erasmus University, Rotterdam, The Netherlands
    J Clin Microbiol 38:4096-101. 2000
    ..Comparative tests with throat swab samples from humans and fecal and cloacal swab samples from birds confirmed that the new PCR is faster and up to 100-fold more sensitive than classical virus isolation procedures...
  54. pmc Investigation of optimal specimen type and sampling time for detection of measles virus RNA during a measles epidemic
    M A Riddell
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
    J Clin Microbiol 39:375-6. 2001
    ..Of lymphocytes, urine, throat swab, and serum specimens, throat swab specimens were optimal for detection of measles virus RNA during the first 2 weeks after the rash...
  55. pmc Induction of lysogenic bacteriophage and phage-associated toxin from group a streptococci during coculture with human pharyngeal cells
    T B Broudy
    Department of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021, USA
    Infect Immun 69:1440-3. 2001
    ..Furthermore, we show that the bacteriophage induction event is mediated by a pharyngeal cell soluble factor for which we provide an initial characterization...
  56. pmc Erythromycin-resistant pharyngeal isolates of Streptococcus pyogenes recovered in Italy
    Giordano Dicuonzo
    Department of Laboratory Medicine Hospital Infection Control Program, Università Campus Bio Medico, Rome, Italy
    Antimicrob Agents Chemother 46:3987-90. 2002
    ..These data suggest a strong association between macrolide resistance and the presence of sof among GAS isolates recovered from Italian pediatric pharyngitis patients...
  57. ncbi The association between laryngopharyngeal sensory deficits, pharyngeal motor function, and the prevalence of aspiration with thin liquids
    Michael Setzen
    North Shore Otolaryngology Associates, Manhasset, NY, USA
    Otolaryngol Head Neck Surg 128:99-102. 2003
    ..The study goal was to evaluate the association among laryngopharyngeal sensory deficits, pharyngeal motor function, and the prevalence of aspiration with thin liquids...
  58. ncbi Behavioral and synaptic defects in C. elegans lacking the NK-2 homeobox gene ceh-28
    Paramita Ray
    Department of Biological Sciences and Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Dev Neurobiol 68:421-33. 2008
    ..We suggest that CEH-28 inhibits synaptogenesis, and that ceh-28 mutant behavioral defects result from excessive or ectopic stimulation of muscarinic acetylcholine receptors in the isthmus muscles...
  59. ncbi [Mechanical sutures of the pharynx during total laryngectomy: proposal of a closed technique]
    C Simoncelli

    Acta Otorhinolaryngol Ital 10:465-74. 1990
    ..The patient does not require a feeding tube since he can swallow from the third day after surgery. None of the patients treated with this technique produced either early or late fistulas, nor did they encounter any trouble in swallowing...
  60. ncbi Pituitary adenylatecyclase-activating polypeptide-immunoreactive nerve fibers in the rat epiglottis and pharynx
    Mitsuhiro Kano
    Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, Sendai, Japan
    Ann Anat 193:494-9. 2011
    ..polypeptide-immunoreactive (PACAP-IR) nerve fibers was studied in the rat epiglottis and pharynx. PACAP-IR nerve fibers were located beneath the mucous epithelium, and occasionally penetrated the epithelium...
  61. ncbi Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4
    J Gaudet
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Science 295:821-5. 2002
    ..We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes...
  62. ncbi A genetic analysis of axon guidance in the C elegans pharynx
    Catarina Mörck
    Lundberg Laboratory, Chalmers University, Medicinaregatan 9C, Box 462, S 405 30, Goteborg, Sweden
    Dev Biol 260:158-75. 2003
    ..We isolated five novel mutants in a screen for worms exhibiting abnormal morphology of the M2 neurons. These mutants define a new gene class designated mnm (M neuron morphology abnormal)...
  63. ncbi Simultaneous real-time measurements of mastication, swallowing, nasal airflow, and aroma release
    M Hodgson
    Division of Food Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK
    J Agric Food Chem 51:5052-7. 2003
    ..The volume of the retronasal route was estimated at 48 mL when swallowing and 72 mL when samples were chewed. The combination of techniques shows the effects of physiological processes on aroma release...
  64. pmc Comparison of cone-beam CT parameters and sleep questionnaires in sleep apnea patients and control subjects
    Reyes Enciso
    Division of Craniofacial Sciences and Therapeutics, School of Dentistry, University of Southern California, Los Angeles, California 90089 0641, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:285-93. 2010
    ....
  65. ncbi Simultaneous detection of five different DNA targets by real-time Taqman PCR using the Roche LightCycler480: Application in viral molecular diagnostics
    Richard Molenkamp
    Academic Medical Center, University of Amsterdam, Department of Medical Microbiology, Laboratory of Clinical Virology, Amsterdam, The Netherlands
    J Virol Methods 141:205-11. 2007
    ..The application of multiplex PCR for the detection of multiple pathogens within the same sample will provide a major contribution to the efficiency, logistics and cost-effectiveness of molecular diagnostics...
  66. pmc Parkinson disease affects peripheral sensory nerves in the pharynx
    Liancai Mu
    Upper Airway Research Laboratory, Department of Research, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA
    J Neuropathol Exp Neurol 72:614-23. 2013
    ..Sensory nerves supplying the pharynx were excised from autopsied pharynges obtained from patients with clinically diagnosed and neuropathologically ..
  67. pmc Comparison of LightCycler PCR, rapid antigen immunoassay, and culture for detection of group A streptococci from throat swabs
    J R Uhl
    Division of Clinical Microbiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Microbiol 41:242-9. 2003
    ..e., testing by the Directigen method with negative results verified by culture)...
  68. pmc Rapid PCR detection of group A Streptococcus from flocked throat swabs: a retrospective clinical study
    Robert Slinger
    Department of Laboratory Medicine, Children s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada
    Ann Clin Microbiol Antimicrob 10:33. 2011
    ..Very few molecular methods for detection of GAS in clinical throat swab specimens have been described...
  69. ncbi Description of Riemerella columbipharyngis sp. nov., isolated from the pharynx of healthy domestic pigeons (Columba livia f. domestica), and emended descriptions of the genus Riemerella, Riemerella anatipestifer and Riemerella columbina
    Dennis Rubbenstroth
    Clinic for Poultry, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Int J Syst Evol Microbiol 63:280-7. 2013
    ..nov. The type strain is 8151(T) (=DSM 24015(T) = LMG 26094(T)). Emended descriptions of the genus Riemerella and of its species Riemerella anatipestifer and Riemerella columbina are also presented...
  70. ncbi The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans
    S E Mango
    Laboratory of Molecular Biology, University of Wisconsin Madison 53706, USA
    Development 120:3019-31. 1994
    ..We propose that pha-4 marks a convergence of the inductive and autonomous pathways of pharyngeal development and suggest that establishment of pharyngeal organ identity is a crucial step for pharyngeal organogenesis...
  71. ncbi Comparison of the area of the pharynx during wakefulness and induced sleep in patients with obstructive sleep apnea (OSA)
    Ana Célia Faria
    Integrated Center for the Study of Facial Deformities Centro Integrado de Estudo das Deformidades da Face CIEDEF, Clinic Hospital, Ribeirao Preto Medical School, Sao Paulo University USP
    Braz J Otorhinolaryngol 78:103-8. 2012
    ..The study of obstructive sleep apnea (OSA) has received growing attention over the past years since various aspects have not been sufficiently established...
  72. ncbi Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement
    C L Ward
    International Clinical Virology, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
    J Clin Virol 29:179-88. 2004
    ..Historically this was measured using plaque assays, or Culture Enhanced Enzyme Linked Immunosorbent Assay (CE-ELISA)...
  73. pmc Wild ducks as long-distance vectors of highly pathogenic avian influenza virus (H5N1)
    Juthatip Keawcharoen
    Erasmus Medical Center, Rotterdam, The Netherlands
    Emerg Infect Dis 14:600-7. 2008
    ....
  74. ncbi Age-related changes of the upper airway assessed by 3-dimensional computed tomography
    Zachary Abramson
    Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Craniofac Surg 20:657-63. 2009
    ..Understanding differences in 3-D airway size and morphology by age may serve as a basis for evaluation of patients with obstructive sleep apnea and may help to predict and to evaluate outcomes of treatment...
  75. ncbi Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification
    Marta Alonso Guervós
    Department of Otorhinolaryngology, IUOPA, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Asturias, Spain
    Oral Oncol 45:600-4. 2009
    Lymph nodes metastasis is a major risk factor related to poor survival in larynx and pharynx carcinomas...
  76. ncbi Synergy between 3'-azido-3'-deoxythymidine and paclitaxel in human pharynx FaDu cells
    Jeffrey S Johnston
    College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    Pharm Res 20:957-61. 2003
    ..enhanced the antitumor activity of paclitaxel, which causes telomere erosion, in telomerase-positive human pharynx FaDu tumors in vitro and in vivo...
  77. ncbi emm typing, antibiotic resistance and PFGE analysis of Streptococcus pyogenes in Lebanon
    Wael Bahnan
    Department of Biology, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon
    J Med Microbiol 60:98-101. 2011
    ..pyogenes recovered not only in Lebanon, but also in neighbouring countries...
  78. ncbi Aroma release and delivery following the consumption of beverages
    M D Hodgson
    Division of Food Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics LE125RD, United Kingdom
    J Agric Food Chem 53:1700-6. 2005
    ..Lipid in the beverage caused a decrease in the intensity of volatile compounds on the breath, but the presence of a thickening agent had no effect on persistence...
  79. ncbi Inflamed adult pharynx tissues and swimming larva of Ciona intestinalis share CiTNFalpha-producing cells
    Nicolo Parrinello
    Department of Animal Biology, Laboratory of Marine Immunobiology, University of Palermo, Via Archirafi 18, 90123, Palermo, Italy
    Cell Tissue Res 341:299-311. 2010
    ..gene (CiTNFalpha), which has been previously cloned and sequenced, is expressed either during the inflammatory pharynx response to lipopolysaccharide (LPS) or during the swimming larval phase of development...
  80. ncbi Evaluation of serological and virological tests in the diagnosis of clinical and subclinical measles virus infections during an outbreak of measles in The Netherlands
    Robert S van Binnendijk
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 188:898-903. 2003
    ..The results of this study emphasize the feasibility of combined detection of viral RNA and MV-specific IgM antibodies in oropharyngeal specimens for the diagnosis of clinical and subclinical MV infection...
  81. ncbi The NK-2 homeobox gene scarecrow (scro) is expressed in pharynx, ventral nerve cord and brain of Drosophila embryos
    S Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 94:237-41. 2000
    ..embryogenesis, scro expression is initially observed in the pharyngeal primordia and later maintained in the pharynx. During band germ retraction, scro expression appears in two bilateral clusters of procephalic neuroblasts that ..
  82. ncbi Diagnostic studies in obstructive sleep apnea
    Kunal Thakkar
    Department of Otolaryngology Head and Neck Surgery, University of Illinois at Chicago, 1855 West Taylor Street, Room 3 87, Chicago, IL 60612, USA
    Otolaryngol Clin North Am 40:785-805. 2007
    ..In this article, the various modalities are reviewed in terms of their capability to effectively diagnose and guide treatment of OSA...
  83. pmc Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain
    Jiang Ping Zhang
    Department of Otolaryngology, Second Hospital of Xi an Jiaotong University, Shaanxi Province, China
    World J Gastroenterol 12:468-72. 2006
    To detect whether there is Helicobacter pylori (H pylori) colonization in the pharynx mucous membrane of healthy people and whether chronic pharyngitis is related to H pylori infection.
  84. pmc Primary involvement of pharynx and peyer's patch in inhalational and intestinal anthrax
    Ian J Glomski
    Unité des Toxines et Pathogénie Bactérienne, Institut Pasteur, Paris, France
    PLoS Pathog 3:e76. 2007
    ..anthracis pathogenesis...
  85. ncbi Investigation of measles and rubella outbreaks in Tamil Nadu, India-2003
    Nalini Ramamurty
    Department of Virology, King Institute of Preventive Medicine, Guindy, Chennai, India
    J Med Virol 78:508-13. 2006
    ..It is necessary to be aware of the circulating genotypes within the geographical area. The information would be valuable to evaluate control measures and identify viral transmission and importation...
  86. ncbi Diagnosis of penetrating injuries of the pharynx and esophagus in the severely injured patient
    Naveed Ahmed
    Department of Surgery, Huron Hospital, Cleveland Clinic, Cleveland, Ohio, USA
    J Trauma 67:152-4. 2009
    ..Radiologic aids may be either unsuitable or unreliable. Videoendoscopy, preferably by the trauma surgeon, affords direct visualization at the bedside and is timely and expeditious...
  87. ncbi Uvulopalatopharyngoplasty with tonsillectomy in the treatment of severe OSAS
    S Gallina
    Dipartimento Neuroscienze Cliniche, U O Otorinolaringoiatria, Universith degli Studi di Palermo, Italia
    B-ENT 5:245-50. 2009
    ..To establish the efficacy of uvulopalatopharyngoplasty with tonsillectomy for treating selected patients with severe obstructive sleep apnea syndrome...
  88. ncbi Inducible galectins are expressed in the inflamed pharynx of the ascidian Ciona intestinalis
    Aiti Vizzini
    Department of Environmental Biology and Biodiversity, Laboratory of Marine Immunobiology, University of Palermo, Via Archirafi 18, 90123 Palermo, Italy
    Fish Shellfish Immunol 32:101-9. 2012
    ..genes were upregulated by LPS inoculation suggesting that they are inducible and expressed in the inflamed pharynx as revealed by real-time PCR analysis...
  89. ncbi Collapsibility of passive pharynx in patients with acromegaly
    S Isono
    Departments of Anesthesiology and Neurosurgery, Chiba University School of Medicine, Chiba, Japan
    Am J Respir Crit Care Med 160:64-8. 1999
    ..However, no study has systematically examined the collapsibility of the pharynx in acromegaly to date...
  90. ncbi Respiration during feeding on solid food: alterations in breathing during mastication, pharyngeal bolus aggregation, and swallowing
    Koichiro Matsuo
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University Hospital, Phipps 160, 600 North Wolfe St, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 104:674-81. 2008
    ..is that alterations in the pattern of respiration during feeding could help prevent inhalation of food from the pharynx. We hypothesized that respiration was inhibited during bolus aggregation in the valleculae...
  91. ncbi Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx
    Mary R Hutson
    Neonatal Perinatal Research Institute, Division of Neonatology, Department of Pediatrics, Box 3179, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 295:486-97. 2006
    ..We hypothesized that neural crest ablation results in elevated FGF8 signaling in the caudal pharynx that disrupts secondary heart field development...
  92. ncbi Airway evaluation in obstructive sleep apnea
    Boris A Stuck
    Department of Otorhinolaryngology, Head and Neck Surgery, Sleep Disorders Center, University Hospital Mannheim, 68135 Mannheim, Germany
    Sleep Med Rev 12:411-36. 2008
    ..So far, there is only very limited evidence that selected techniques improve treatment outcome for selected indications. In general, there is not enough evidence that these techniques are superior to the routine clinical assessment...
  93. ncbi Normal standard curve for acoustic pharyngometry
    I Kamal
    ENT Department, Police Authority Hospital, Cairo, Egypt. ibrahimkamal.hotmail.com
    Otolaryngol Head Neck Surg 124:323-30. 2001
    ..331). Mean glottic area was 1.06 cm(2) in males (SD 0.119) and 0.936 cm(2) in females (SD 0.108). A minimal pharyngeal area is probably needed as a "golden standard" to evaluate patients with obstructive sleep apnea...
  94. ncbi Respiratory lumenal change of the pharynx and trachea in normal subjects and COPD patients: assessment by cine-MRI
    Claus Peter Heussel
    Department of Radiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Eur Radiol 14:2188-97. 2004
    ..study was to use cine-MRI during continuous respiration to measure the respiratory lumenal diameter change in the pharynx and at an upper tracheal level...
  95. ncbi Effect of pharynx epithelial cells surface desialylation on receptor-mediated adherence of Staphylococcus aureus
    S Sakarya
    Department of Infectious Diseases and Clinical Microbiology, ADUBILTEM Research and Development Center, School of Medicine, Adnan Menderes University, Aydin, Turkey
    J Appl Microbiol 108:1313-22. 2010
    ..To characterize the interaction between cell surface carbohydrates and Staphylococcus aureus...
  96. ncbi Hypercapnia enhances the development of coughing during continuous infusion of water into the pharynx
    T Nishino
    Department of Anesthesiology, School of Medicine Chiba University, Japan
    Am J Respir Crit Care Med 157:815-21. 1998
    ..the coordination of respiration and reflex swallowing elicited by continuous infusion of distilled water into the pharynx (2.5 ml/min) in 11 normal subjects...
  97. ncbi The third and fourth tropomyosin isoforms of Caenorhabditis elegans are expressed in the pharynx and intestines and are essential for development and morphology
    A Anyanful
    Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    J Mol Biol 313:525-37. 2001
    ..Finally, to demonstrate that tropomyosin is essential for development, we inactivated the body wall and pharynx-specific isoforms by RNA-mediated interference...
  98. pmc Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx
    Thomas J Baiga
    Howard Hughes Medical Institute, Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    ACS Chem Biol 3:294-304. 2008
    ..These studies provide cogent evidence supporting the roles of the glycosylated fatty acid daumone and related ascarosides and the ubiquitous plant flavone apigenin as chemical cues regulating C. elegans development...
  99. ncbi Serotonin induces four pharmacologically separable contractile responses in the pharynx of the leech Hirudo medicinalis
    B A O'Gara
    Department of Biological Sciences, Barnard College of Columbia University, New York, NY 10027 6598, USA
    Gen Pharmacol 32:669-81. 1999
    Stimulation of the serotoninergic innervation of the leech pharynx or application of serotonin to the isolated pharynx induced four distinct types of contractile activity: an increase in basal tonus, large phasic contractions of 10-15 s ..
  100. pmc Survey of emm-like gene sequences from pharyngeal isolates of group C and group G streptococci collected in Spain
    Sebastian Alberti
    Unidad de Investigacion, Edificio D, 1a planta, Hospital Universitario Son Dureta, Andrea Doria 55, Palma de Mallorca 07014, Spain
    J Clin Microbiol 43:1433-6. 2005
    ..Five emm-like sequences accounted for more than 50% of the isolates in group C and group G, suggesting horizontal gene transfer between strains of different species...
  101. ncbi Use of Muller's maneuver in the evaluation of patients with sleep apnea--literature review
    Maria Claudia Mattos Soares
    EPM, UNIFESP
    Braz J Otorhinolaryngol 75:463-6. 2009
    ..Fiberoptic nasopharyngoscopy with Muller's maneuver, first described by Borowieck and Sassin (1983), is among them...

Research Grants64

  1. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..their interactions with tobacco and alcohol use, in the etiology of squamous cell carcinomas of the oral cavity, pharynx, and larynx (SCCHN), expanding our findings of a novel apoptosis mechanism that has not been described before...
  2. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..tumors arising from a variety of sites in the upper aerodigestive tract (UADT), including the oral cavity, the pharynx, and the larynx. HNC represents the fifth most common malignancy worldwide...
  3. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..is instead caused by a subset of the commensal bacteria that comprise the normal flora of the pediatric naso- pharynx (NP)...
  4. H. influenzae Genes Associated with Acute Otitis Media
    Janet R Gilsdorf; Fiscal Year: 2010
    ..genes offering increased bacterial fitness in the middle ear that are not required for NTHi colonization of the pharynx, we will use prevalence analysis, as performed on a whole bacterial genomic DNA microarray, to identify NTHi ..
  5. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2013
    ..use as well as p53 mutations and HPV infections, in the etiology of squamous cell carcinomas of the oral cavity, pharynx, and larynx (SCCHN), expanding our findings of a novel apoptosis mechanism that has not been described before...
  6. Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
    TIRUNELVELI RAMALINGAM; Fiscal Year: 2013
    ..Flexible fiber-optic or rigid endoscopes are normally inserted through the nose or into the pharynx for conventional physical examinations, but endoscopy alone cannot be used to differentiate between benign, pre-..
  7. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ..The co-occurrence of birth defects of the heart, face, and structures of the pharynx reflects not only their common embryological origin from a cardiocraniofacial field, but also that the normal ..
  8. Host-pathogen signaling in group A streptococcal infection
    Michael R Wessels; Fiscal Year: 2012
    ..and recurrent infection likely reflect, in part, the exquisite adaptation of GAS for survival in the human pharynx. GAS is exclusively a human pathogen, and its preferred environmental niche is the human throat...
  9. Aging and Regeneration in a basal chordate
    Anthony W De Tomaso; Fiscal Year: 2013
    ..but that soon metamorphoses into an invertebrate adult, which has a complex body plan that includes a heart, pharynx, GI tract, nervous system, complex vasculature and blood...
  10. Development of a canine model of radiotherapy induced oral mucositis
    Dorothy C Brown; Fiscal Year: 2010
    ..term for the erythematous, inflammatory, and ulcerative lesions that occur in the mucosal lining of the mouth and pharynx secondary to cytotoxic cancer therapy...
  11. VERTEBRATE PRIMARY MOUTH FORMATION
    Hazel L Sive; Fiscal Year: 2013
    ..The primary mouth (also called the stomodeum) is the first opening between the outside and the developing pharynx, and is the earliest element of craniofacial development...
  12. Cholinergic receptors on the nematode pharynx: an unexploited drug target
    Alan P Robertson; Fiscal Year: 2012
    ..Once such site is the nicotinic acetylcholine receptor on the nematode pharynx. We have discovered this receptor does not respond to currently used anrthelmintic drugs...
  13. Gene Regulatory Networks in Development and Physiology
    ALBERTHA JOHANNA WALHOUT; Fiscal Year: 2013
    ..elegans as a model system to study metazoan GRNs. The digestive tract is composed of the pharynx, intestine and rectum, its development has been well documented, and multiple regulators expressed in this system ..
  14. Effects of Bolus Accommodation on Swallowing Effort in Healthy Elderly Individual
    Lisa A Lagorio; Fiscal Year: 2011
    ..1 mm diameter manometric catheter inserted trans-nasally into the pharynx. Sensors will be integrated with the fluoroscopy equipment to capture oral and pharyngeal effort and hyo-..
  15. Function and regulation of T-box factors in C. elegans
    Peter G Okkema; Fiscal Year: 2010
    The C. elegans pharynx is distinct neuromuscular organ consisting of several very different cell types, including muscles, neurons and epithelia cells...
  16. EGFR-targeted Polymeric Micelles for Targeted Pc 4-PDT of Oropharyngeal Tumors
    ALYSSA MANECK MASTER; Fiscal Year: 2013
    ..Cancers of the buccal cavity, head and neck subset, larynx, pharynx, and nose/nasal passages is the seventh most common cause of cancer death in the US...
  17. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2012
    ..dysphagia in PD is associated with biological and neuochemical changes in the sensori-motor structures of the pharynx. The neural alterations in the sensory nerves could impair initiation of reflex swallowing, whereas those in the ..
  18. Tongue-pressure timing for liquid flow detection and control in swallowing
    CATRIONA MARGARET STEELE; Fiscal Year: 2012
    ..plays a critical role in containing liquids in the mouth, and in directing and controlling flow through the pharynx (throat)...
  19. Role of Endothelin Receptor B signaling in the genesis of aganglionic megacolon
    Miles L Epstein; Fiscal Year: 2012
    ..nervous system (ENS) develops primarily from a cohort of neural crest- derived cells (ENCCs) that enter at the pharynx before advancing caudally through the developing gut...
  20. ORGANOGENESIS OF THE PHARYNX IN C ELEGANS
    Susan E Mango; Fiscal Year: 2013
    ..My lab has a longstanding interest in organogenesis of the foregut, or pharynx, with a particular focus on its transcriptional regulatory processes. C...
  21. Chibby and Wnt Signaling in Ciliated Cell Differentiation
    Ken Ichi Takemaru; Fiscal Year: 2013
    ..tract, and beat synchronously in waves to propel inhaled debris and pathogens entrapped in mucus to the pharynx. This provides an important innate defense mechanism against respiratory infections...
  22. Function and organization of the Drosophila pharynx
    RYAN MATTHEW JOSEPH; Fiscal Year: 2013
    ..this proposal is to characterize fundamental properties of chemosensory function, using gustatory neurons in the pharynx of Drosophila melanogaster as a model for investigating taste-based behaviors...
  23. Strategies for the Treatment of Dysphagia in Patients with Alzheimer's Disease
    Jerilyn A Logemann; Fiscal Year: 2013
    ..they cannot coordinate tongue movements to initiate a swallow in the mouth or to propel the food back to the pharynx. Since they don't recognize food as food in their mouth, Alzheimer's patients do not respond to ..
  24. Microfluidic devices for high-throughput anthelmintic screens
    Shawn R Lockery; Fiscal Year: 2010
    ..The new procedure is based on the observation that the nematode throat, or pharynx, is extremely sensitive to the anthelmintics that also affect the nervous system...
  25. Exploring Cigarette Dependence among African-American Males in Barbershops.
    Alton Hart; Fiscal Year: 2010
    ..as White men for the past 10 years, African-American men have the highest incidence and death rates from oral/pharynx, pancreatic, esophageal, and lung larynx cancers...
  26. Regulation of Airway Protective Behaviors
    Teresa E Pitts; Fiscal Year: 2013
    ..oral material (saliva, food and liquid), by epiglottal movement, laryngeal adduction, and clearing the mouth and pharynx. Cough is an aspiration- response behavior that clears material from the airway...
  27. Multiscale mechanisms of lingual mechanical function
    Richard J Gilbert; Fiscal Year: 2013
    ..role during swallowing, first to configure and then to propel the ingested bolus from the oral cavity to the pharynx. Disorders of lingual mechanical function are exceedingly common in the elderly and patients with neurological ..
  28. Characterization of upstream factors regulating the C. elegans T-box gene tbx-2
    ANGENEE CARY MILTON; Fiscal Year: 2012
    ..characterizing a tbx-2 transcriptional enhancer that is necessary and sufficient for expression in the embryonic pharynx. My objective is to identify cis-acting sequences important for enhancer activity, and to identify and ..
  29. Human Microbiome and Healthcare Associated Infections
    Mary Claire Roghmann; Fiscal Year: 2013
    ..We propose to study the microbiome of the anterior nares, posterior pharynx and two skin sites in two populations with and without on-going exposure to the healthcare environment: (a) ..
  30. High Resolution Manometry: A Novel Pattern Recognition Method for Dysphagia
    Timothy M McCulloch; Fiscal Year: 2012
    ..adaptive muscular contractions to produce pressures and valving events throughout the oral cavity, laryngo-pharynx and esophagus...
  31. High Resolution Manometry: A Novel Pattern Recognition Method for Dysphagia
    Timothy M McCulloch; Fiscal Year: 2013
    ..adaptive muscular contractions to produce pressures and valving events throughout the oral cavity, laryngo-pharynx and esophagus...
  32. Mechanisms of Swallow Control of Breathing
    KENDALL FRANCIS MORRIS; Fiscal Year: 2013
    ..The sCPG must reconfigure the respiratory neural network because many of the muscles used for control of the pharynx and larynx during breathing are also used during swallow...
  33. Nighttime Acoustic Pharyngometer (NAP) for Airway Obstruction Identification
    HANI KAYYALI; Fiscal Year: 2009
    ..Current methods are either inaccurate or invasive whereby catheters are placed deep in the pharynx for prolonged periods of time making these studies uncomfortable and unpopular...
  34. Investigation of genetic variation in the alcohol metabolism genes and other key
    JAMES DOWLING MCKAY; Fiscal Year: 2011
    ..factors, genetic variation is also thought to play a role in susceptibility to cancers of the oral cavity and pharynx. The goal of this project is to investigate new findings from a separate genome wide association study of upper-..
  35. Coordination of Respiration with Deglutition & Phonation in Ataxia-Telangiectasia
    Maureen Lefton Greif; Fiscal Year: 2007
    ..linkage between breathing and swallowing is critical for airway protection because these functions share the pharynx as a common pathway. Disruption of this linkage is a significant concern in diseases with oropharyngeal dysphagia...
  36. WHOLE GENOME SHOTGUN SEQUENCING OF STREPTOCOCCUS MITIS
    Herve Tettelin; Fiscal Year: 2001
    ..The predominance of IgA1 protease producing S. mitis variants in the pharynx is associated with allergic disease. S. mitis is a causative agent of endocarditits...
  37. Metagenomic Studies of MRSA Colonization
    Mary Claire Roghmann; Fiscal Year: 2013
    ..In a clinical trial, we propose to study the microbiome of the anterior nares and posterior pharynx in populations with and without current exposure to the healthcare environment: (a) MRSA-colonized, community-..
  38. Tongue-Jaw Linkages in Feeding
    Jeffrey Palmer; Fiscal Year: 2005
    ..to this model is the notion that foods are processed in the oral cavity but the swallow bolus formed in the pharynx. Movement of food in and through the oral cavity depends primarily on coordinated motions of the jaw, hyoid, and ..
  39. Dysphagia and Recovery After Vagal or Laryngeal Nerve Injury
    Rebecca Z German; Fiscal Year: 2013
    ..integrity of the peripheral neural pathways for safe and efficient transport of the bolus through the mouth and pharynx. Due to its extensive anatomic course and vulnerability to disease and trauma, injury to the vagus and its ..
  40. SLEEP INFLUENCE ON THE PHARYNX AND VENTILATORY CONTROL
    Clifford Zwillich; Fiscal Year: 1993
    ..Many investigators agree that the fundamental feature of most apneas is complete occlusion of the pharynx. Pharyngeal occlusion is a "state-dependent" event which occurs only during sleep and often requires arousal for ..
  41. Smokeless Tobacco Use and Cessation in Rural Appalachia
    MARY WEWERS; Fiscal Year: 2003
    ..risk factor for a variety of oral pathoses such as gingival recession, leukoplakia and cancers of the mouth and pharynx. Rural Appalachians are at risk for tobacco-related diseases and very little is known about their smokeless ..
  42. AN ECM SCAFFOLD FOR HEAD AND NECK REPAIR
    Alan Spievack; Fiscal Year: 2001
    ..surgical repair/reconstruction of head and neck structures such as the palate, tongue, nose and orbit, larynx, pharynx, and facial skin structures presently involves the use of complicated autograft procedures, mechanical devices, ..
  43. Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma
    Norma Nowak; Fiscal Year: 2009
    Approximately 500,000 new cases of head and neck squamous cell carcinoma (HNSCC), including the oral cavity, pharynx and larynx, are reported each year...
  44. COORDINATION OF RESPIRATION AND DEGLUTITION
    ADRIENNE PERLMAN; Fiscal Year: 2003
    The close proximity of the larynx to the entrance of the esophagus, and the common pathway through the pharynx that both air and a swallowed bolus must traverse, require that swallowing and respiration be well coordinated...
  45. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..A number of observations from the PI's laboratory show that pharynx is a source of important afferent stimulus that triggers LES relaxation...
  46. Analysis Of Group A Streptococcus-Saliva Interaction
    SAMUEL SHELBURNE; Fiscal Year: 2009
    ..Also, given that saliva coats the posterior pharynx, there is constant interplay between saliva and GAS during pharyngeal infection...
  47. Improving Cancer Outcomes for African-Americans
    Patrick Maguire; Fiscal Year: 2007
    ..compared with whites, for cancers of the uterine cervix, lung and bronchus, prostate, larynx, oral cavity and pharynx, breast, colon and rectum, and soft tissue...
  48. Effects of LSVT on Dysphagia in Parkinson's Disease
    Jerilyn Logemann; Fiscal Year: 2003
    ..as secondary measures, the changes in bolus transit times, the observation of percentage residue in the mouth and pharynx, the frequency of swallowing motility disorders and the temporal measures of swallow...
  49. Chemoresistance in Renal Cell Cancer
    JESSIE AU; Fiscal Year: 2006
    ..c) aFGF/bFGF induced chemoresistance in other human solid tumor cells (i.e., lung ovarian, colon, pharynx)...
  50. OBSTRUCTIVE SLEEP APNEA & PERIODIC BREATHING IN SLEEP
    JOHN REMMERS; Fiscal Year: 1991
    ..mechanical factors responsible for pharyngeal closure, we shall visualize the lumen of the naso-, oro- and hypo-pharynx while nasal airway positive pressure is applied during sleep in normals, snorers and patients with obstructive ..
  51. NEUROMUSCULAR ACTIVITY OF THE PHARYNX DURING SWALLOWING
    Jeffrey Palmer; Fiscal Year: 1991
    ..of this project is analysis of the neuromuscular mechanism by which a swallowed bolus is propelled through the pharynx into the esophagus...
  52. Lingual Mechanical Function During Swallowing
    Richard Gilbert; Fiscal Year: 2005
    ..deglutition, the tongue first configures, then propels the ingested bolus from the oral cavity retrograde to the pharynx. From a clinical perspective, disorders of lingual function are exceedingly common in the elderly, in association ..
  53. SLEEP APNEA--MUSCULAR CONTROL OF PHARYNGEAL PATENCY
    LAUREL WIEGAND; Fiscal Year: 1993
    ..The fundamental feature of most apneas is complete occlusion of the pharynx. Pharyngeal occlusion is a "state-dependent" event which occurs only during sleep and often requires arousal for ..
  54. AN ECM SCAFFOLD FOR HEAD AND NECK REPAIR
    Alan Spievack; Fiscal Year: 2000
    ..surgical repair/reconstruction of head and neck structures such as the palate, tongue, nose and orbit, larynx, pharynx, and facial skin structures...
  55. Gene Environment Interaction in Head and Neck Cancer
    Andrew Olshan; Fiscal Year: 2005
    ..susceptibility in the etiology of squamous cell carcinoma of the head and neck (SCCHN; including oral cavity, pharynx, and larynx)...
  56. ESOPHAGEAL MOTILITY AND AIRWAY DEFENSES AMONG INFANTS
    SUDARSHAN JADCHERLA; Fiscal Year: 2003
    ..infant mortality and morbidity with enormous socioeconomic consequences, might be related to motor functions of pharynx, esophagus, or stomach which may be dependent upon neural control and muscular function...
  57. ROLE OF HUMAN NASAL MUCOSAL P450 IN HEAD AND NECK CANCER
    Xinxin Ding; Fiscal Year: 2001
    ..plays an important role in the chemical carcinogenesis in the nasal cavity and neighboring organs, including the pharynx, larynx, and the oral cavity, where toxic metabolites formed in the nasal mucosa can be transported...
  58. SEROLOGIC PRECURSORS OF CANCER
    George Comstock; Fiscal Year: 1990
    ..proposed to extend these assays to melanomas and to cancers of the breast, cervix, endometrium, kidney, mouth and pharynx, and ovary, again with two controls matched to each case...
  59. PHARYNGEAL RESISTANCE IN SLEEPING PREMATURE INFANTS
    MARTHA MILLER; Fiscal Year: 1993
    ..The pharynx contributes 80% of supraglottic resistance in the supine infant and is most vulnerable to collapse during apnea...
  60. POLYAMINE MODULATION OF SQUAMOUS CANCER GROWTH KINETICS
    Paul Harari; Fiscal Year: 1999
    ..primary treatment modality for squamous cell carcinomas (SCCs) of the head and neck (H&N) region (ie, tongue, pharynx, larynx)...
  61. A GENETIC PATHWAY REQUIRED FOR PHARYNGEAL ARCH DEVELOPME
    Antonio Baldini; Fiscal Year: 2003
    ..The pharynx lacks the characteristic segmented pattern to assume a tube-like morphology...
  62. HPV ETIOLOGY OF A SUBSET OF HEAD AND NECK CANCERS
    Keerti Shah; Fiscal Year: 2004
    ..hypothesis that a subset of head and neck squamous cell carcinomas (HNSCC-defined as SCC of the oral cavity, the pharynx and the larynx for this proposal) is etiologically linked to infections with human papillomaviruses (HPVs)...
  63. Mechanisms of Organ Regeneration in the planarian Schmidtea mediterranea
    Carolyn Adler; Fiscal Year: 2009
    ..I will focus on the pharynx, which can be selectively amputated and completely regenerates within ten days...
  64. Phe-1 and C elegans Pharynx Morphogenesis
    Jennifer Saam; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) We are studying tubulogenesis of the C. elegans foregut or pharynx to understand morphogenesis of the digestive tract. The pharynx primordium is initially organized as a cyst...