olfactory mucosa

Summary

Summary: That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.

Top Publications

  1. ncbi Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish
    Yuki Sato
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:4889-97. 2005
  2. pmc A novel olfactory receptor gene family in teleost fish
    Luis R Saraiva
    Institute of Genetics, University of Cologne, D 50674 Cologne, Germany
    Genome Res 17:1448-57. 2007
  3. ncbi Expression of members of the putative olfactory receptor gene family in mammalian germ cells
    M Parmentier
    IRIBHN, Universite Libre de Bruxelles, Belgium
    Nature 355:453-5. 1992
  4. ncbi Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 75:463-76. 1993
  5. pmc Nested expression domains for odorant receptors in zebrafish olfactory epithelium
    F Weth
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, Tubingen, Germany
    Proc Natl Acad Sci U S A 93:13321-6. 1996
  6. ncbi Diversity in the olfactory epithelium of bony fishes: development, lamellar arrangement, sensory neuron cell types and transduction components
    Anne Hansen
    Department of Cell and Developmental Biology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, USA
    J Neurocytol 34:183-208. 2005
  7. pmc High-throughput microarray detection of olfactory receptor gene expression in the mouse
    Xinmin Zhang
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 101:14168-73. 2004
  8. pmc Widespread ectopic expression of olfactory receptor genes
    Ester Feldmesser
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 7:121. 2006
  9. pmc Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate
    Kimberly K Gokoffski
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:4131-42. 2011
  10. pmc Terminal nerve-derived neuropeptide y modulates physiological responses in the olfactory epithelium of hungry axolotls (Ambystoma mexicanum)
    Angela Mousley
    School of Biological Sciences, Queen s University Belfast, Belfast BT9 7BL, United Kingdom
    J Neurosci 26:7707-17. 2006

Research Grants

  1. A NOVEL METHOD TO TREAT CHRONIC PAIN
    SATHYANARAYANA N MURTHY; Fiscal Year: 2013
  2. Therapeutic rescue of an olfactory ciliopathy
    JEREMY MCINTYRE; Fiscal Year: 2012
  3. Anterior Olfactory Nucleus
    Peter C Brunjes; Fiscal Year: 2013
  4. INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULI
    Ruth Wood; Fiscal Year: 2006
  5. ROLE OF HUMAN NASAL MUCOSAL P450 IN HEAD AND NECK CANCER
    Xinxin Ding; Fiscal Year: 2001
  6. SENSORY NEUROTOXICOLOGY - TOXIC METALS AND OLFACTION
    Lloyd Hastings; Fiscal Year: 1993
  7. GENETIC MICROSYSTEMS GMS417 ARRAY SEQUENCER/418 ARRAYER
    Lorraine Flaherty; Fiscal Year: 2000
  8. OLFACTORY MECHANISMS OF CORTICOSTEROID ACTION
    Robert Kern; Fiscal Year: 2000
  9. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
  10. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004

Detail Information

Publications319 found, 100 shown here

  1. ncbi Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish
    Yuki Sato
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:4889-97. 2005
    ....
  2. pmc A novel olfactory receptor gene family in teleost fish
    Luis R Saraiva
    Institute of Genetics, University of Cologne, D 50674 Cologne, Germany
    Genome Res 17:1448-57. 2007
    ....
  3. ncbi Expression of members of the putative olfactory receptor gene family in mammalian germ cells
    M Parmentier
    IRIBHN, Universite Libre de Bruxelles, Belgium
    Nature 355:453-5. 1992
    ..Our finding suggests that a common receptor gene family encodes olfactory receptors and sperm cell receptors that could be involved in chemotaxis during fertilization...
  4. ncbi Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 75:463-76. 1993
    ..These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages...
  5. pmc Nested expression domains for odorant receptors in zebrafish olfactory epithelium
    F Weth
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Physikalische Biologie, Tubingen, Germany
    Proc Natl Acad Sci U S A 93:13321-6. 1996
    ..This might represent the first step of spatial encoding of olfactory input or be essential for the development of the olfactory system...
  6. ncbi Diversity in the olfactory epithelium of bony fishes: development, lamellar arrangement, sensory neuron cell types and transduction components
    Anne Hansen
    Department of Cell and Developmental Biology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, USA
    J Neurocytol 34:183-208. 2005
    ..There is not sufficient information to draw conclusions regarding the diversity of teleost olfactory receptors or transduction cascades...
  7. pmc High-throughput microarray detection of olfactory receptor gene expression in the mouse
    Xinmin Zhang
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 101:14168-73. 2004
    ..This correlation between genomic location and spatial expression provides unique insights about the regulation of this large family of genes...
  8. pmc Widespread ectopic expression of olfactory receptor genes
    Ester Feldmesser
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    BMC Genomics 7:121. 2006
    ..The present study systematically explores the expression patterns of OR genes in a large number of tissues and assesses the potential functional implication of such ectopic expression...
  9. pmc Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate
    Kimberly K Gokoffski
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:4131-42. 2011
    ..Thus, our findings demonstrate a close connection between the signals involved in the control of tissue size and those that regulate the proportions of different cell types...
  10. pmc Terminal nerve-derived neuropeptide y modulates physiological responses in the olfactory epithelium of hungry axolotls (Ambystoma mexicanum)
    Angela Mousley
    School of Biological Sciences, Queen s University Belfast, Belfast BT9 7BL, United Kingdom
    J Neurosci 26:7707-17. 2006
    ....
  11. ncbi Effects of human OEC-derived cell transplants in rodent spinal cord contusion injury
    Catherine Anne Gorrie
    Neural Injury Research Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    Brain Res 1337:8-20. 2010
    ..In this study hOECs were derived from biopsies of human olfactory mucosa, purified by culture in a serum-free medium containing neurotrophin-3, genetically labelled with EGFP, and ..
  12. ncbi Protocols for two- and three-color fluorescent RNA in situ hybridization of the main and accessory olfactory epithelia in mouse
    Tomohiro Ishii
    The Rockefeller University, New York, NY 10021, USA
    J Neurocytol 33:657-69. 2004
    ..The protocol is applied to cryosections of the main and accessory olfactory epithelia in mouse...
  13. pmc Neural crest origin of olfactory ensheathing glia
    Perrine Barraud
    Department of Physiology, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 107:21040-5. 2010
    ....
  14. ncbi Lamina propria and olfactory bulb ensheathing cells exhibit differential integration and migration and promote differential axon sprouting in the lesioned spinal cord
    Miranda W Richter
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 25:10700-11. 2005
    ....
  15. ncbi Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage
    Elise Cau
    IGBMC, 1 rue Laurent Fries, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 129:1871-80. 2002
    ..These results illustrate the versatility of neural bHLH genes which adopt either a determination or a differentiation function, depending primarily on the timing of their expression in neural progenitors...
  16. ncbi Multipotent stem cells from adult olfactory mucosa
    Wayne Murrell
    Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
    Dev Dyn 233:496-515. 2005
    ..Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and ..
  17. ncbi Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb
    Kazunari Miyamichi
    Core Research for Evolutional Science and Technology, The University of Tokyo, Tokyo 113 0032, Japan
    J Neurosci 25:3586-92. 2005
    ..The present study indicates that the OR gene choice may be more restricted by the OSN location in the OE than what has been thought...
  18. pmc Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles
    Ivan Manzini
    Physiologisches Institut, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 546:375-85. 2003
    ..This endows ORNs with the ability to transport a large number of substrates including calcium-indicator dyes and calcein across their plasma membranes. Conversely, blocking P-glycoprotein and MRP increases the net uptake of these dyes...
  19. ncbi Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization
    Aya Kato
    Department of Integrated Biosciences, The University of Tokyo, Room 201, 5 1 5, Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Cell Mol Life Sci 66:3743-53. 2009
    ..A greater understanding of the molecular mechanisms underlying OR activity may help in the discovery of agonists and antagonists of ORs, and of GPCRs with potential therapeutic applications...
  20. ncbi Neural regeneration and the peripheral olfactory system
    James E Schwob
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Anat Rec 269:33-49. 2002
    ..Rather, odorant receptor-defined subclasses of neurons innervate an excessive number of glomeruli in the rough vicinity of their original glomerular targets...
  21. ncbi Shared and unique G alpha proteins in the zebrafish versus mammalian senses of taste and smell
    Yuichiro Oka
    Institut fur Genetik, Universitat zu Koln, Zülpicher Strasse 47a, Koln, Germany
    Chem Senses 36:357-65. 2011
    ..Our results show general similarity to the mammalian situation but also clear-cut differences and as such are essential for using the zebrafish model system to study chemosensory perception...
  22. ncbi Morphometric and ultrastructural comparison of the olfactory system in elasmobranchs: the significance of structure-function relationships based on phylogeny and ecology
    Vera Schluessel
    School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
    J Morphol 269:1365-86. 2008
    ..This is the first comprehensive study comparing olfactory morphology to several aspects of elasmobranch ecology in a phylogenetic context...
  23. ncbi Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury
    Paul Lu
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093, USA
    J Neurosci 26:11120-30. 2006
    ....
  24. ncbi Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth
    Louisa C E Windus
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan 4111, Brisbane, QLD, Australia
    Cell Mol Life Sci 68:3233-47. 2011
    ..These results demonstrate that the migration of OECs strongly regulates the motility of axons and that stimulation of OEC motility enhances axon extension and growth cone activity...
  25. ncbi Histological and ultrastructural characteristics of the primordial vomeronasal organ in lungfish
    Shoko Nakamuta
    Laboratory of Veterinary Anatomy, Faculty of Agriculture, Iwate University, Morioka, Iwate 020 8550, Japan
    Anat Rec (Hoboken) 295:481-91. 2012
    ..This study may provide important clues to elucidate how the vomeronasal organ emerged during the evolution of vertebrates...
  26. ncbi Trafficking and secretion of matrix metalloproteinase-2 in olfactory ensheathing glial cells: A role in cell migration?
    Yatma Gueye
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, UMR 6184 CNRS Université Aix Marseille II, Faculte de Medecine, CS80011, Bd Pierre Dramard, 13344 Marseille Cedex 15, France
    Glia 59:750-70. 2011
    ..Finally, we show that MMPs are involved in migration of OECs in vitro on different ECM substrates...
  27. ncbi Mesenchymal/epithelial induction mediates olfactory pathway formation
    A S LaMantia
    Department of Cell and Molecular Physiology and Center for Neuroscience, The University of North Carolina at Chapel Hill, Medical School, 27599, USA
    Neuron 28:411-25. 2000
    ..Thus, a cellular and molecular mechanism that facilitates musculoskeletal and vascular development elsewhere in the embryo has been adapted to guide the differentiation of the olfactory pathway in the developing forebrain...
  28. ncbi Crypt cells of the zebrafish Danio rerio mainly project to the dorsomedial glomerular field of the olfactory bulb
    José Gayoso
    Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruna, A Coruna, Spain
    Chem Senses 37:357-69. 2012
    The olfactory mucosa of the zebrafish consists of 3 morphological types of olfactory receptor neurons (ORNs): ciliated, microvillous, and crypt cells...
  29. ncbi A comparative study of glial and non-neural cell properties for transplant-mediated repair of the injured spinal cord
    Andrew Toft
    Spinal Cord Group, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    Glia 61:513-28. 2013
    ..Thus, purified glial cells have advantages for transplant-mediated repair, combining maximal support for axonal regeneration with a minimal astrocytic reaction around the transplant site...
  30. ncbi Differential distribution of olfactory receptor neurons in goldfish: structural and molecular correlates
    Anne Hansen
    Rocky Mountain Taste and Smell Center, Cell and Developmental Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Comp Neurol 477:347-59. 2004
    ..V2R- and OR-type receptor molecules do not colocalize in one cell, and only crypt-type ORNs express more than one G-protein...
  31. ncbi Expression of vomeronasal receptor genes in Xenopus laevis
    Kimiko Hagino-Yamagishi
    Department of Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    J Comp Neurol 472:246-56. 2004
    ..The analysis of V2R expression in Xenopus larvae demonstrates that V2Rs are predominantly expressed in the VNO even before metamorphosis...
  32. ncbi Odorant tuning of olfactory crypt cells from juvenile and adult rainbow trout
    Alejandra Bazáes
    Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaiso, Avda Gran Bretaña 1111, 2360102 Playa Ancha, Valparaiso, Chile
    J Exp Biol 215:1740-8. 2012
    ..These results support an involvement of olfactory crypt cells in reproduction-related olfactory signaling in fishes...
  33. ncbi CX₃CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium
    Linda V Blomster
    School of Anatomy and Human Biology, The University of Western Australia, Perth, Australia
    Mol Cell Neurosci 48:236-45. 2011
    ....
  34. pmc Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model
    Nicolas Granger
    Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK
    Brain 135:3227-37. 2012
    ..However, we find no evidence for concomitant improvement in long tract function...
  35. ncbi Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice
    Diego Restrepo
    Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Horm Behav 46:247-56. 2004
    ..In each case, one system or the other (or both) participates in a specific behavioral or hormonal response...
  36. pmc Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices
    Shami Kanekar
    Department of Physiology, University of Utah, Salt Lake City, Utah, USA
    J Neurosci Res 87:1424-34. 2009
    ....
  37. pmc NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium
    Cuihong Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA
    Neurobiol Dis 38:405-13. 2010
    ..These data indicate that ATP initiates neuroproliferation via NPY upregulation, NPY release, and Y1 receptor activation, and suggests that the olfactory epithelium is good model to study neuroregenerative mechanisms in the CNS...
  38. pmc Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa
    Lei Li
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    J Pharmacol Exp Ther 339:62-71. 2011
    ..catalytic efficiency of microsomal NA epoxygenases in lung (up to ~160-fold), liver (~3-fold), and nasal olfactory mucosa (OM; up to ~16-fold), and significant decreases in rates of systemic NA (300 mg/kg i.p.) clearance...
  39. ncbi Multipotency of purified, transplanted globose basal cells in olfactory epithelium
    Xueyan Chen
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Comp Neurol 469:457-74. 2004
    ..The results suggest that progenitor cell transplantation may prove useful as a therapeutic modality as well as an analytical tool...
  40. ncbi Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa
    Shimona Gayle
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK
    Cell Tissue Res 319:27-36. 2005
    ..P2Y2 receptor immunoreactivity was localised to the mucus-secreting cells within the VNO. The possible functional roles of these receptors are discussed...
  41. pmc ATP differentially upregulates fibroblast growth factor 2 and transforming growth factor α in neonatal and adult mice: effect on neuroproliferation
    C Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 177:335-46. 2011
    ..These data suggest that different mechanisms regulate neurogenesis in neonatal and adult OE, and FGF2 and TGFα may have different roles throughout development...
  42. ncbi Widespread defects in the primary olfactory pathway caused by loss of Mash1 function
    Richard C Murray
    Department of Anatomy and Neurobiology, Developmental Biology Center, University of California, Irvine, Irvine, California 92697 2300, USA
    J Neurosci 23:1769-80. 2003
    ....
  43. pmc Chemotopic odorant coding in a mammalian olfactory system
    Brett A Johnson
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    J Comp Neurol 503:1-34. 2007
    ..A critical analysis suggests that alternative coding mechanisms for odor quality, such as those based on temporal patterns of responses, enjoy little experimental support...
  44. pmc Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT, 06516, USA
    Neurosci Lett 456:137-42. 2009
    ..In this review we focus on several unique features of OECs when they are transplanted into the spinal cord...
  45. ncbi Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli
    Yuki Oka
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Neuron 52:857-69. 2006
    ..Our results provide a methodology to examine in vivo glomerular responses at the receptor level and further help address the long-standing issues of olfactory sensitivity and specificity under physiological conditions...
  46. ncbi Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction
    Simone Pifferi
    SISSA, International School for Advanced Studies, and Italian Institute of Technology, SISSA Unit, via Bonomea 265, 34136 Trieste, Italy
    Exp Physiol 97:193-9. 2012
    ..Finally, we discuss the involvement of Ca(2+)-activated Cl(-) channels in the transduction process of vomeronasal sensory neurons and the physiological role of these channels in olfaction...
  47. pmc Expression of pax6 and sox2 in adult olfactory epithelium
    Zhen Guo
    Cell, Molecular, and Developmental Biology Graduate Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
    J Comp Neurol 518:4395-418. 2010
    ..Each of the Sox2/Pax6-colabeled cell types is at a remove from the birth of neurons; thus, suppressing their differentiation may be among the roles of Sox2/Pax6 in the olfactory epithelium...
  48. ncbi Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium
    S Bauer
    Unité Mixte de Recherche 5020 Centre National de la Recherche Scientifique, Université Lyon I, 69622 Villeurbanne, France
    J Neurosci 23:1792-803. 2003
    ..Taken together, these results suggest that injured OSNs release LIF as a stimulus to initiate their own replacement...
  49. ncbi Correlation between olfactory receptor cell type and function in the channel catfish
    Anne Hansen
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 23:9328-39. 2003
    ..Finally, amino acid odorants activate both ciliated and microvillous ORNs but via different transduction pathways in the two types of cells...
  50. ncbi The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo
    J Martin Collinson
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Dev Biol 255:303-12. 2003
    ....
  51. ncbi Odorant stimulation enhances survival of olfactory sensory neurons via MAPK and CREB
    William C Watt
    Department of Pharmacology, The University of Washington, Seattle, WA 98195, USA
    Neuron 41:955-67. 2004
    ..We further demonstrate that odorant stimuli rescue OSNs in a cAMP-dependent manner by activating the MAPK/CREB-dependent transcriptional pathway, possibly as a result of expression of Bcl-2...
  52. ncbi The electroolfactogram: a review of its history and uses
    John W Scott
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Microsc Res Tech 58:152-60. 2002
    ..A number of technical issues associated with EOG recording are also discussed...
  53. pmc Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial
    A Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
    Brain 131:2376-86. 2008
    ....
  54. pmc Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons
    Dyke P McEwen
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48105, USA
    Proc Natl Acad Sci U S A 104:15917-22. 2007
    ..The assessment of olfactory function can, therefore, serve as a useful diagnostic tool for genetic screening of certain syndromic ciliary diseases...
  55. ncbi Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology
    Barbara Murdoch
    Departments of Zoology and Medicine, University of British Columbia, Vancouver, BC, Canada
    J Mol Histol 38:581-99. 2007
    ..of evidence that support the existence of a heterogeneous population of neural and glial progenitors in the olfactory mucosa, and highlight the differences in the identity and activity of progenitors found in the embryonic and adult ..
  56. ncbi Tmem16b is specifically expressed in the cilia of olfactory sensory neurons
    Sebastian Rasche
    Neuroscience Research Center, Charite, Universitatsmedizin Berlin, 10117 Berlin, Germany
    Chem Senses 35:239-45. 2010
    ..Native Tmem16b is localized in the cilia of the OSNs, which is in agreement with previous electrophysiological recordings...
  57. ncbi Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium
    E Cau
    IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
    Development 127:2323-32. 2000
    ..Therefore, the olfactory sensory neuron lineage is regulated at several steps by negative signals acting through different Hes genes and targeting the expression of different proneural gene homologs...
  58. ncbi Modeling inspiratory and expiratory steady-state velocity fields in the Sprague-Dawley rat nasal cavity
    Geoffrey C Yang
    Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, 240 Skirkanich Hall 6321, 210 S 33rd Street, Philadelphia, PA 19104, USA
    Chem Senses 32:215-23. 2007
    ..The rat nasal velocity calculations will be used to study the distribution of odorant uptake onto the rat olfactory mucosa and compare it with the known anatomic location of some types of rat olfactory receptors.
  59. ncbi Mouse olfactory sensory neurons express 10,000 genes
    Neeraja Sammeta
    Department of Physiology, Cellular and Molecular Neuroscience of Sensory Systems Training Program, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 502:1138-56. 2007
    ..Within limits prescribed by the nature of microarray data and the in situ hybridization validation, these data should be useful in directing further experiments on OSN function...
  60. pmc Differentially expressed transcripts from phenotypically identified olfactory sensory neurons
    Tun Tzu Yu
    Department of Physiology and The Cellular and Molecular Neuroscience of Sensory Systems Program, The University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 483:251-62. 2005
    ..Within the olfactory epithelium, Cbr2 is a new anatomical marker for sustentacular cells. We also discovered that Reg3g is a marker for respiratory epithelium...
  61. ncbi Olfactory transmission of neurotropic viruses
    Isamu Mori
    Department of Microbiology and Immunology, Research Center for Infectious Disease, Aichi Medical University School of Medecine, Aichi, Japan
    J Neurovirol 11:129-37. 2005
    ..Here the authors review the olfactory transmission of infectious agents and the resulting hazards to human and animal health...
  62. ncbi Specific projection of the sensory crypt cells in the olfactory system in crucian carp, Carassius carassius
    El Hassan Hamdani
    Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindern, 0316 Oslo, Norway
    Chem Senses 31:63-7. 2006
    ..Because this bundle of the tract mediates reproductive behavior, it is conceivable that crypt cells express olfactory receptors for sex pheromones...
  63. ncbi TRPM5-expressing solitary chemosensory cells respond to odorous irritants
    Weihong Lin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    J Neurophysiol 99:1451-60. 2008
    ..Together, our data show that the TRPM5-expressing cells respond to a variety of chemicals at high exposure levels typical of irritants and are positioned in the nasal cavity appropriately to monitor inhaled air quality...
  64. pmc Genomics of mature and immature olfactory sensory neurons
    Melissa D Nickell
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 520:2608-29. 2012
    ..This OSN gene database not only predicts the genes responsible for the major biological processes active in OSNs, but also identifies thousands of never before studied genes that support OSN phenotypes...
  65. pmc Olfactory mechanisms of stereotyped behavior: on the scent of specialized circuits
    Lisa Stowers
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 20:274-80. 2010
    ..This review focuses on these non-VNO receptors and neurons, and evaluates their potential for mediating stereotyped olfactory behavior in mammals...
  66. ncbi Patient-derived olfactory mucosa cells but not lung or skin fibroblasts mediate axonal regeneration of retinal ganglion neurons
    Vega García-Escudero
    Department of Molecular Biology, Universidad Autonoma de Madrid, 28049 Cantoblanco, Spain
    Neurosci Lett 509:27-32. 2012
    Although human olfactory mucosa derived cells (OMC) have been used in animal models and clinical trials with CNS repair purposes, the exact identity of these cells in culture with respect to their tissue of origin is not fully understood ..
  67. ncbi Asynchronous onset of odorant receptor expression in the developing zebrafish olfactory system
    A L Barth
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 16:23-34. 1996
    ....
  68. pmc p63 regulates olfactory stem cell self-renewal and differentiation
    Russell B Fletcher
    Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute and Functional Genomics Laboratory, University of California, Berkeley, CA 94720 3200, USA
    Neuron 72:748-59. 2011
    ..These results provide critical insight into the genetic regulation of the olfactory stem cell in vivo and more generally provide an entrée toward understanding the coordination of stem cell self-renewal and differentiation...
  69. ncbi Enhancement of the growth and differentiation of nasal olfactory mucosa cells by the conjugation of growth factors to functional nanoparticles
    Hadas Skaat
    Department of Chemistry, Bar Ilan Institute of Nanotechnology and Advanced Materials, Ramat Gan, Israel
    Bioconjug Chem 22:2600-10. 2011
    ..In the present study, nasal olfactory mucosa (NOM) cells from adult rats were cultured in suspension on chitosan microcarriers (MCs) in the presence of ..
  70. ncbi Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons
    Jeremy C McIntyre
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci Res 88:3243-56. 2010
    ....
  71. pmc Functional identification and reconstitution of an odorant receptor in single olfactory neurons
    K Touhara
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    Proc Natl Acad Sci U S A 96:4040-5. 1999
    ..The present approach should enable us to examine not only ligand specificity of an odorant receptor but also receptor specificity and diversity for a particular odorant of interest...
  72. pmc A balance of BMP and notch activity regulates neurogenesis and olfactory nerve formation
    Esther Maier
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 6:e17379. 2011
    ....
  73. ncbi Limited functional recovery in rats with complete spinal cord injury after transplantation of whole-layer olfactory mucosa: laboratory investigation
    Masanori Aoki
    Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosurg Spine 12:122-30. 2010
    The olfactory mucosa (OM) consists of 2 layers, the epithelium and the lamina propria...
  74. ncbi Sequential onset of presynaptic molecules during olfactory sensory neuron maturation
    Florencia Marcucci
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Comp Neurol 516:187-98. 2009
    ..In addition, contact with the targets in the olfactory bulb is not controlling presynaptic protein gene expression, suggesting that olfactory sensory neurons follow an intrinsic program of development...
  75. pmc Differential expression of components of the retinoic acid signaling pathway in the adult mouse olfactory epithelium
    CAROLYN E PELUSO
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Comp Neurol 520:3707-26. 2012
    ..phenotype, for example, differential expression of odorant receptors and cell adhesion molecules across the olfactory mucosa (OM)...
  76. ncbi Nucleotide-induced Ca2+ signaling in sustentacular supporting cells of the olfactory epithelium
    Thomas Hassenklöver
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Humboldtallee 23, Gottingen, Germany
    Glia 56:1614-24. 2008
    ..Our findings suggest that extracellular nucleotides in the OE activate SCs via P2Y2/P2Y4-like receptors and initiate a characteristic intraepithelial Ca2+ wave...
  77. ncbi Competence, specification and commitment to an olfactory placode fate
    Sujata Bhattacharyya
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Development 135:4165-77. 2008
    ....
  78. ncbi Olfactory ensheathing cells: the primary innate immunocytes in the olfactory pathway to engulf apoptotic olfactory nerve debris
    Zhida Su
    Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, China
    Glia 61:490-503. 2013
    ..Importantly, engulfment of olfactory nerve debris by OECs was found in olfactory mucosa under normal turnover and was significantly increased in the animal model of olfactory bulbectomy, while ..
  79. ncbi The effects of unilateral naris occlusion on gene expression profiles in mouse olfactory mucosa
    David M Coppola
    Department of Biology, Randolph Macon College, Ashland, VA 23005, USA
    J Mol Neurosci 47:604-18. 2012
    ..key genes involved in olfactory reception, transduction, and transmission were up-regulated in deprived-side olfactory mucosa, with opposite effects in non-deprived-side mucosa, compared to controls...
  80. ncbi Purinergic signaling regulates cell proliferation of olfactory epithelium progenitors
    Thomas Hassenklöver
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Gottingen, Germany
    Stem Cells 27:2022-31. 2009
    ..Our data contribute to a better understanding of the regulation of the cell turnover in the OE in particular and also of how the proliferation of neuronal progenitor cells is regulated in general...
  81. pmc Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry rats
    Julia Negroni
    INRA, UR1197 Neurobiologie de l Olfaction et Modélisation en Imagerie, Jouy en Josas, France
    PLoS ONE 7:e45266. 2012
    ..have recently demonstrated that another nutritional cue, insulin, modulates the odorant responses of the rat olfactory mucosa (OM)...
  82. ncbi Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors
    Nanaho Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Eur J Neurosci 27:2665-75. 2008
    ..Our findings suggest that IP3R2 and IP3R3 mediate nasal mucus secretion, which is important for the maintenance of nasal tissue as well as the perception of odors...
  83. pmc Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium
    Jennifer L Pluznick
    Department of Cellular and Molecular Physiology, Yale School of Medicine New Haven, Connecticut, United States of America
    PLoS ONE 6:e19694. 2011
    ..These data show that multiple renal cystic proteins localize to the OE, where we speculate that they work together to regulate aspects of the development, maintenance or physiological activities of cilia...
  84. pmc Neuropeptide Y and extracellular signal-regulated kinase mediate injury-induced neuroregeneration in mouse olfactory epithelium
    Cuihong Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Mol Cell Neurosci 49:158-70. 2012
    ..There were no synergistic effects of ATP and NPY or FGF2 on OE neuroregeneration. These data clearly have implications for the pharmacological modulation of neuroregeneration in the olfactory epithelium...
  85. ncbi The proteome of rat olfactory sensory cilia
    Ulrich Mayer
    Department of Molecular Physiology, Institute of Zoology, University of Heidelberg, Heidelberg, Germany
    Proteomics 9:322-34. 2009
    ..Organellar proteomics thus yielded decisive information about the diverse physiological functions of a sensory organelle...
  86. ncbi Odorant receptor expression patterns are restored in lesion-recovered rat olfactory epithelium
    Carrie L Iwema
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 24:356-69. 2004
    ..Thus, the primary sensory elements required for functional recovery of the olfactory system after damage are restored, and altered function implies the persistence of a more central failure in regeneration...
  87. pmc ATP mediates neuroprotective and neuroproliferative effects in mouse olfactory epithelium following exposure to satratoxin G in vitro and in vivo
    Cuihong Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 124:169-78. 2011
    ..These data indicate that ATP is released and promotes cell proliferation via activation of purinergic receptors in SG-induced OE injury. Thus, the purinergic system is a therapeutic target to alleviate or restore the loss of OSNs...
  88. ncbi Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Int J Dev Biol 54:1453-64. 2010
    ....
  89. pmc V-ATPase expression in the mouse olfactory epithelium
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 295:C923-30. 2008
    ..These findings suggest that V-ATPase may be involved in proton secretion in the OE and, as such, may be important for the pH homeostasis of the neuroepithelial mucous layer and/or for signal transduction in CO(2) detection...
  90. ncbi CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium
    Marc J Ruitenberg
    School of Anatomy and Human Biology, Faculty of Life and Physical Sciences, The University of Western Australia, Crawley, Australia
    J Neuroimmunol 205:80-5. 2008
    ..These observations are first to demonstrate phenotypic differences in appearance and distribution of monocyte-derived cells in nervous tissue due to CX3CR1 deficiency...
  91. pmc Activation of purinergic receptors induces proliferation and neuronal differentiation in Swiss Webster mouse olfactory epithelium
    C Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48823, USA
    Neuroscience 163:120-8. 2009
    ..We propose that extracellular ATP released upon injury could induce proliferation and promote the neuroregeneration of the olfactory epithelium...
  92. ncbi Neuropeptide Y in the olfactory microvillar cells
    Giorgia Montani
    Department of Neuroscience, University of Parma, Via Volturno, 39, I 43100, Parma, Italy
    Eur J Neurosci 24:20-4. 2006
    ..Our findings allow for the first time to suggest that microvillar cells are involved in connecting apoptosis to neuronal regeneration by stimulus-induced release of NPY...
  93. pmc Nickel sulfate induces location-dependent atrophy of mouse olfactory epithelium: protective and proliferative role of purinergic receptor activation
    Cuihong Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 115:547-56. 2010
    ..These data provide therapeutic strategies to alleviate or cure the loss of olfactory function associated with exposure to nickel compounds...
  94. ncbi Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats
    Nicolas Thiebaud
    Centre des Sciences du Gout et de l Alimentation, UMR 1324 INRA, UMR 6265 CNRS, Universite de Bourgogne, AgroSup Dijon, 17 rue Sully, Dijon, France
    Drug Metab Dispos 38:1865-75. 2010
    Several xenobiotic-metabolizing enzymes (XMEs) have been identified in the olfactory mucosa (OM) of mammals. However, the molecular mechanisms underlying the regulation of these enzymes have been little explored...
  95. ncbi The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis
    Esther Breunig
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, 37073 Gottingen, Germany
    J Neurosci 30:8965-73. 2010
    ..Hunger renders olfactory neurons more sensitive. Endocannabinoid modulation in the nose may therefore substantially influence food-seeking behavior...
  96. pmc PACAP protects against TNFα-induced cell death in olfactory epithelium and olfactory placodal cell lines
    Shami Kanekar
    Department of Physiology, University of Utah, Salt Lake City, UT 84108, USA
    Mol Cell Neurosci 45:345-54. 2010
    ..PACAP may therefore function through PAC1 receptors to protect neurons from cell death during inflammatory cytokine release in vivo as would occur upon viral infection or allergic rhinitis-associated injury...
  97. pmc State-dependent sculpting of olfactory sensory neurons is attributed to sensory enrichment, odor deprivation, and aging
    Melissa Ann Cavallin
    Department of Biology, University of West Georgia, Carrollton, GA, USA
    Neurosci Lett 483:90-5. 2010
    ..These findings suggest that voltage-gated activity of the mitral cells is important for OSN plasticity, and can prevent neuronal loss via sensory- and OR-dependent mechanisms...
  98. ncbi Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa
    Anne Laure Minn
    UMR 1234 Toxicologie Alimentaire, INRA Université de Bourgogne, Faculte de Pharmacie, 7, boulevard Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Drug Metab Dispos 33:1229-37. 2005
    ..Many recent studies have pointed out the presence of xenobiotic-metabolizing enzymes in rat olfactory mucosa (OM)...
  99. ncbi Olfactory transduction in ciliated receptor neurons of the Cabinza grunt, Isacia conceptionis (Teleostei: Haemulidae)
    Oliver Schmachtenberg
    Centro de Neurociencias de Valparaiso, Facultad de Ciencias, Universidad de Valparaiso, Avda Gran Bretania 1111, Playa Ancha, Valparaiso, Chile
    Eur J Neurosci 20:3378-86. 2004
    ....
  100. ncbi Cloning and expression of odorant-binding proteins Ia and Ib from mouse nasal tissue
    D Pes
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa, Italy
    Gene 212:49-55. 1998
    ..In-situ hybridisation has revealed identical expression patterns for the two proteins, further supporting the heterodimeric structure of these proteins in the nasal mucus...
  101. ncbi Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis
    Isamu Mori
    Department of Microbiology, Fukui Medical University School of Medicine, 23 3 Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    J Gen Virol 83:2109-16. 2002
    ..These results raise the possibility that induction of apoptosis in olfactory receptor neurons at an early stage of infection may provide protective effects against invasion of the neurovirulent virus from the peripheral to the CNS...

Research Grants62

  1. A NOVEL METHOD TO TREAT CHRONIC PAIN
    SATHYANARAYANA N MURTHY; Fiscal Year: 2013
    ..The permeation of drug and drug-TPGS nano co-micelles across the olfactory mucosa will be investigated in vitro, in presence and absence of BMAs...
  2. Therapeutic rescue of an olfactory ciliopathy
    JEREMY MCINTYRE; Fiscal Year: 2012
    ..Individual olfactory sensory neurons (OSNs) contain over 20 cilia that project into the olfactory mucosa and are responsible for detecting odorants...
  3. Anterior Olfactory Nucleus
    Peter C Brunjes; Fiscal Year: 2013
    ..Nevertheless, it has been virtually ignored compared with studies of the olfactory mucosa, bulb and piriform cortex...
  4. INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULI
    Ruth Wood; Fiscal Year: 2006
    ..Aim 2A will investigate the transduction of rewarding chemosensory cues in the olfactory mucosa and/or vomeronasal organ. Aims 2B and 2C will focus on central targets of the olfactory bulbs...
  5. ROLE OF HUMAN NASAL MUCOSAL P450 IN HEAD AND NECK CANCER
    Xinxin Ding; Fiscal Year: 2001
    The long-term goal is to determine the toxic impact of environmental agents on the olfactory mucosa and neighboring head and neck organs. The specific aims for this proposal are: (1)...
  6. SENSORY NEUROTOXICOLOGY - TOXIC METALS AND OLFACTION
    Lloyd Hastings; Fiscal Year: 1993
    ..has focused on the heavy metals, cadmium and nickel; in this protocol , zinc, due to its potent effect on the olfactory mucosa will be evaluated...
  7. GENETIC MICROSYSTEMS GMS417 ARRAY SEQUENCER/418 ARRAYER
    Lorraine Flaherty; Fiscal Year: 2000
    ..memory and cerebellar development, identifying human genes important for degeneration and regeneration of olfactory mucosa, determining factors involved in DNA exchange in Mycobacterium, identifying genes controlled by cell cycle ..
  8. OLFACTORY MECHANISMS OF CORTICOSTEROID ACTION
    Robert Kern; Fiscal Year: 2000
    This research is designed to evaluate the hypothesis that the olfactory mucosa is subject to regulation by adrenal corticosteroid hormones, including the mineralocorticoid aldosterone, as well as glucorticoid hormones...
  9. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ..dietary exposure to alachlor causes a variety of tumors, including adenomas and adneocarcinoams of the olfactory mucosa in rats...
  10. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..of rats to the chloracetanilide herbicide alachlor causes tumor formation in multiple sites, including the olfactory mucosa, thyroid, and stomach...
  11. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    The peripheral olfactory mucosa is a fascinating model system for several reasons...
  12. CYCLIC NUCLEOTIDE PHOSPHODIESTERASES IN OLFACTION
    James Cherry; Fiscal Year: 1999
    ..Regulation of this enzyme will then be examined during degeneration and subsequent regeneration of the olfactory mucosa following unilateral removal of the olfactory bulb, which is the target of the sensory neuron axons...
  13. PHYSIOLOGICAL ANALYSIS OF THE OLFACTORY PROJECTIONS
    John Scott; Fiscal Year: 2006
    ..These results will be of importance for understanding the sense of smell. ..
  14. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  15. Unconventional receptor neurons in nasal epithelia
    ANNELOTTE HANSEN; Fiscal Year: 2008
    ..abstract_text> ..
  16. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  17. FEEDBACK REGULATION OF NEUROGENESIS IN MAMMALS
    ANNE CALOF; Fiscal Year: 2007
    ..These studies will provide insights into the molecular mechanisms by which neuron number -- and therefore, ultimately, function -- are regulated during development and regeneration of the mammalian nervous system. ..
  18. BEHAVIORAL ANALYSIS OF OMPS ROLE IN ODOR PROCESSING
    STEVEN YOUNGENTOB; Fiscal Year: 2003
    ..e., at the transduction level) and may provide insight into a therapeutic strategy that has implications for a variety of neurological disorders. ..
  19. VITAMIN A STATUS/EFFECTS ON OLFACTORY NEURON MATURATION
    Mary Ann Asson Batres; Fiscal Year: 2004
    ..The PI is committed to a career in biomedical research with a focus on chemosensory systems. With this award, the PI can increase her independent research capability and become competitive for NIV R01-level funding. ..
  20. In utero ethanol experience and olfactory plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..It will also establish a chemosensory related conceptual framework of fetal exposure with broad based importance in child development and drug abuse. ..
  21. DEVELOPING A RAPID SCREEN TO DETECT OLFACTORY MUTANTS
    STEVEN YOUNGENTOB; Fiscal Year: 2001
    ..For each phase, we will provide detailed information via a Web-based database linked to centralized resources. ..
  22. Cytokines on Olfactory Receptor Neuron Function
    Andrew Lane; Fiscal Year: 2006
    ..Additional bench research will be performed in the laboratory of Dr. Schleimer, an established scientist with expertise in airway inflammation and cytokine modulation of cell function. ..
  23. ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONS
    Thomas Getchell; Fiscal Year: 2005
    ..Understanding the signaling regulating neurogenesis in the OE will yield insights into mechanisms for restoring olfactory function compromised by aging, trauma, and neurodegenerative diseases. ..
  24. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2005
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  25. Putative pheromones in the main olfactory system
    Weihong Lin; Fiscal Year: 2007
    ..abstract_text> ..
  26. Interaction of ApoE with Estrogen in the Olfactory System
    Britto Nathan; Fiscal Year: 2008
    ..A better understanding of the apoE-estrogen interaction is vital to the therapeutic usefulness of estrogens in postmenopausal women. [unreadable] [unreadable] [unreadable]..
  27. Mechanisms of prion transport
    RICHARD BESSEN; Fiscal Year: 2008
    ..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion transmission. ..
  28. Genomic of Olfactory Regeneration
    Timothy S McClintock; Fiscal Year: 2010
    ..The proposed experiments will definitively test whether several proteins are dispensable for olfactory development and regeneration, and will define the potential roles of a couple dozen additional proteins. ..
  29. FUNCTIONAL DOMAINS AND EXPRESSION OF OLFACTORY RECEPTORS
    Timothy S McClintock; Fiscal Year: 2010
    ..This project is an integrated approach to understanding the genes whose activity is important for generating the phenotype of mature olfactory sensory neurons and then maintaining these cells in the face of significant challenges. ..
  30. Gene Expression Profiling of Adult Olfactory Stem and Progenitor Cells
    JAMES SCHWOB; Fiscal Year: 2008
    ..The information gathered here may allow us eventually to use these adult stem cells in treating nervous system damage and degenerative disease. [unreadable] [unreadable] [unreadable]..
  31. DEVELOPMENT OF THE PRIMARY OLFACTORY PROJECTION
    JAMES SCHWOB; Fiscal Year: 2005
    ..Attempts to foster recovery in the clinical population require an understanding in depth of the inherent limits and capacities for regeneration. ..
  32. MOLECULAR MECHANISMS OF OLFACTORY INTEGRATION
    TIMOTHY MCCLINTOCK; Fiscal Year: 2003
    ..The Principal Investigator will transfect mutant forms of these proteins into primary cultured olfactory neurons to assess whether they have predicted effects on olfactory transduction. ..
  33. Synaptic connectivity in mouse accessory olfactory bulb
    Ricardo Araneda; Fiscal Year: 2005
    ..It is anticipated that these studies will have an impact on our understanding of the sensory coding of pheromonal information and other olfactory information by the accessory olfactory system. ..
  34. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2004
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  35. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2001
    ....
  36. MRNA AND PROTEIN DYNAMICS IN IDENTIFIED NEURONS
    TIMOTHY MCCLINTOCK; Fiscal Year: 2001
    ..abstract_text> ..
  37. Strategies for Restoring Olfactory Neurogenesis
    JAMES SCHWOB; Fiscal Year: 2004
    ..abstract_text> ..
  38. Neurobiology of Dysbindin in Schizophrenia and sdy Mouse
    STEVEN ARNOLD; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. Lifelong Development of the Vomeronasal Epithelium
    JESSICA BRANN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. OLFACTORY NEURODEVELOPMENTAL PATHOLOGY IN SCHIZOPHRENIA
    STEVEN ARNOLD; Fiscal Year: 2002
    ..The relative densities of immunohistochemically distinct populations of neurons will be determined and the spatial arrangement of neurons will be assessed using spatial point pattern analyses. ..
  41. Novel transgenic mouse models for human p450 research
    Xinxin Ding; Fiscal Year: 2005
    ....
  42. Development & Maturation of Kidney Xenobiotic Transport
    Sanjay Nigam; Fiscal Year: 2005
    ..Together, these studies should provide key insights not only into the development and maturation of renal drug handling capacity but also into mechanisms of proximal tubulogenesis. ..
  43. OLFACTORY TOXICITY OF ENVIRONMENTAL AGENTS
    Xinxin Ding; Fiscal Year: 2010
    ..in the current funding period and those proposed for the new funding cycle involve two nasal structures, the olfactory mucosa (OM) and the lateral nasal gland (LNG)...
  44. Factor Mediating Ureteric Migration and Morphogenesis
    Sanjay K Nigam; Fiscal Year: 2010
    ..The experiments are based on considerable preliminary data and follow directly from work completed during the previous funding period. We have proven expertise in the techniques necessary to complete the project. ..
  45. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  46. Mice with olfactory mucosa-specific Cre gene expression
    Xinxin Ding; Fiscal Year: 2003
    ..is to generate mice with tissue- specific expression of the Cre gene in the non-neuronal cells of the olfactory mucosa. These mice will be valuable for subsequent studies to specifically disrupt a given gene in the Cre-..
  47. NHERF IN BETA-2-ADRENERGIC RECEPTOR SIGNALING
    Randy Hall; Fiscal Year: 2003
    ..These studies will provide insight into hovel signaling pathways activated by the beta2AR, a receptor that is a common target for therapeutics used in the treatment of hypertension, heart disease and other disorders. ..
  48. Injury-Evoked Regeneration Mechanism in Olfactory System
    Colleen Hegg; Fiscal Year: 2008
    ..Agents that modify the effects of purinergics and purinergic receptors are readily available and could therapeutically modulate cell proliferation and differentiation, in the olfactory system and in the CNS. ..
  49. Gap Junctions and Connexins in Developing CNS
    JOHN RASH; Fiscal Year: 2005
    ....
  50. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ....
  51. Signal transduction in the vomeronasal organ
    JESSICA BRANN; Fiscal Year: 2005
    ..In addition, I will examine the role of the protein-protein interaction between the two types of ion channels in the propagation of the odor response. ..
  52. MEMBRANE MECHANISMS OF OLFACTORY TRANSDUCTION
    Frank Zufall; Fiscal Year: 2006
    ..abstract_text> ..
  53. Neuroinformatic Analysis of Olfactory Coding
    Michael Leon; Fiscal Year: 2006
    ..The combination of these approaches should help resolve the differences between the conflicting models of olfactory coding. ..
  54. PROPERTIES OF OLFACTORY RECEPTORS - NEURAL REGENERATION
    RICHARD COSTANZO; Fiscal Year: 2009
    ..abstract_text> ..
  55. Neural substrates of taste, smell and flavor in humans
    DANA SMALL; Fiscal Year: 2006
    ..g., Alzheimer's disease) or patients who may respond abnormally to food stimuli (e.g., bulimia). This research will also provide important information into the nature of polymodal sensory integration. [unreadable] [unreadable]..
  56. Interactions Between Nicotine Addiction and Food Reward
    DANA SMALL; Fiscal Year: 2006
    ..If brain response does predict weight gain then we will have developed a method to identify individuals at risk for relapse so that they can be targeted for further therapeutic intervention. [unreadable] [unreadable] [unreadable]..
  57. Cell migration and differentiation in the olfactory bulb
    Adam Puche; Fiscal Year: 2004
    ..Understand the mechanisms of SVZ progenitor migration through the olfactory bulb and cues governing phenotype selection have important implications for the use of these cells as clinical therapy. ..
  58. Neuregulin 1-erbB signaling in schizophrenia
    Chang Gyu Hahn; Fiscal Year: 2009
    ..Aim 2 will specifically address protein protein interactions among erbB4 and other PSD proteins. Aim 3, will further characterize the impact of erbB4 dysregulation on NMDAR signaling and explore possible mechanisms. ..
  59. Individual Differences in Olfaction
    CHARLES WYSOCKI; Fiscal Year: 2008
    ..To do this, we will assess individual behavioral responses to odors and characterize the genes for olfactory receptors that are found within the person's genome. ..
  60. MOLECULAR GERONTOLOGY OF THE HUMAN OLFACTORY SYSTEM
    MARILYN GETCHELL; Fiscal Year: 2002
    The human olfactory mucosa, olfactory bulb, and anterior olfactory nucleus exhibit cellular, molecular, and functional changes as a correlate of aging and of Alzheimer's disease...