nose

Summary

Summary: A specialized structure that serves as an organ of the sense of smell as well as part of the respiratory system; the term includes both the external nose and the nasal cavity.

Top Publications

  1. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
  2. ncbi The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
  3. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
  4. doi Experimental infection of bats with Geomyces destructans causes white-nose syndrome
    Jeffrey M Lorch
    Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 480:376-8. 2011
  5. pmc Neurological impacts from inhalation of pollutants and the nose-brain connection
    R G Lucchini
    Department of Experimental and Applied Medicine, Section of Occupational Health, University of Brescia, Brescia, Italy
    Neurotoxicology 33:838-41. 2012
  6. doi Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization
    Tadayuki Iwase
    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105 8461 Japan
    Nature 465:346-9. 2010
  7. pmc Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome
    Lisa Warnecke
    Department of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, Winnipeg, MB, Canada R3B 2E9
    Proc Natl Acad Sci U S A 109:6999-7003. 2012
  8. pmc Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination
    Alexander Fleischmann
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 60:1068-81. 2008
  9. ncbi What determines nasal carriage of Staphylococcus aureus?
    S J Peacock
    Dept of Microbiology, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Trends Microbiol 9:605-10. 2001
  10. pmc Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans
    Marios Chatzigeorgiou
    Cell Biology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Neuron 70:299-309. 2011

Detail Information

Publications330 found, 100 shown here

  1. ncbi Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    N Engl J Med 344:11-6. 2001
    ..We examined S. aureus isolates from blood and from nasal specimens to determine whether the organisms in the bloodstream originated from the patient's own flora...
  2. ncbi The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
    ..The nose is the main ecological niche where S aureus resides in human beings, but the determinants of the carrier state are ..
  3. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
    ..While spa-type t108 is apparently a more widespread clone among pig farmers and their environment, we did find other spa-types...
  4. doi Experimental infection of bats with Geomyces destructans causes white-nose syndrome
    Jeffrey M Lorch
    Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 480:376-8. 2011
    White-nose syndrome (WNS) has caused recent catastrophic declines among multiple species of bats in eastern North America...
  5. pmc Neurological impacts from inhalation of pollutants and the nose-brain connection
    R G Lucchini
    Department of Experimental and Applied Medicine, Section of Occupational Health, University of Brescia, Brescia, Italy
    Neurotoxicology 33:838-41. 2012
    ..An increased understanding of the neurotoxicity associated with air pollution exposure is critical to protect susceptible individuals in the workplace and the general population...
  6. doi Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization
    Tadayuki Iwase
    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105 8461 Japan
    Nature 465:346-9. 2010
    ..These findings indicate that Esp hinders S. aureus colonization in vivo through a novel mechanism of bacterial interference, which could lead to the development of novel therapeutics to prevent S. aureus colonization and infection...
  7. pmc Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome
    Lisa Warnecke
    Department of Biology and Centre for Forest Interdisciplinary Research, University of Winnipeg, Winnipeg, MB, Canada R3B 2E9
    Proc Natl Acad Sci U S A 109:6999-7003. 2012
    White-nose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by the fungus Geomyces destructans (Gd), and responsible for devastating declines of bat populations in eastern North America...
  8. pmc Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination
    Alexander Fleischmann
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 60:1068-81. 2008
    We have altered the neural representation of odors in the brain by generating a mouse with a "monoclonal nose" in which greater than 95% of the sensory neurons express a single odorant receptor, M71...
  9. ncbi What determines nasal carriage of Staphylococcus aureus?
    S J Peacock
    Dept of Microbiology, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Trends Microbiol 9:605-10. 2001
    ..aureus, together with the observation that persistent carriers often carry a single strain whereas intermittent carriers can be colonized with unrelated strains over time, suggests that bacterial factors could also be involved...
  10. pmc Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans
    Marios Chatzigeorgiou
    Cell Biology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Neuron 70:299-309. 2011
    The nematode C. elegans senses head and nose touch using multiple classes of mechanoreceptor neurons that are electrically coupled through a network of gap junctions...
  11. ncbi Is nose-to-brain transport of drugs in man a reality?
    Lisbeth Illum
    Identity, 19 Cavendish Crescent North, The Park, Nottingham NG7 1BA, UK
    J Pharm Pharmacol 56:3-17. 2004
    ..A wealth of studies has reported proof of nose-to-brain delivery of a range of different drugs in animal models, such as the rat...
  12. pmc Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice
    Bruno Gonzalez-Zorn
    Unite des Agents Antibacteriens, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Infect Immun 73:1847-51. 2005
    ..aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice...
  13. pmc Frequent arousal from hibernation linked to severity of infection and mortality in bats with white-nose syndrome
    Deeann M Reeder
    Department of Biology, Bucknell University, Lewisburg, Pennsylvania, United States of America
    PLoS ONE 7:e38920. 2012
    White-nose syndrome (WNS), an emerging infectious disease that has killed over 5.5 million hibernating bats, is named for the causative agent, a white fungus (Geomyces destructans (Gd)) that invades the skin of torpid bats...
  14. doi Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus
    Nelianne J Verkaik
    Departments of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 199:625-32. 2009
    ..Persistent carriers have a higher risk of Staphylococcus aureus infections than noncarriers but a lower risk of bacteremia-related death. Here, the role played by anti-staphylococcal antibodies was studied...
  15. pmc Prevalence of methicillin-resistant Staphylococcus aureus nasal colonization among Taiwanese children in 2005 and 2006
    Yhu Chering Huang
    Division of Pediatric Infectious Diseases, Chang Gung Children s Hospital and Chang Gung Memorial Hospital at Linko, Kaohsiung, Taiwan
    J Clin Microbiol 45:3992-5. 2007
    ..We concluded that between 2005 and 2006, 7.3% of healthy Taiwanese children were colonized by MRSA in nares. MRSA harbored in healthy children indicates an accelerated spread in the community...
  16. ncbi The clonality of Staphylococcus aureus nasal carriage
    Christian Cespedes
    Division of Infectious Diseases, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Infect Dis 191:444-52. 2005
    ..The present study demonstrates that carriage of discordant S. aureus strains in individuals with nasal colonization occurs regularly and suggests that the nares are likely sites for horizontal genetic exchange among strains...
  17. doi Nasal swab screening for methicillin-resistant Staphylococcus aureus--how well does it perform? A cross-sectional study
    Ann Matheson
    Health Protection Scotland, Glasgow, United Kingdom
    Infect Control Hosp Epidemiol 33:803-8. 2012
    ..To determine the proportion of methicillin-resistant Staphylococcus aureus (MRSA) detections identified by nasal swabbing using agar culture in comparison with multiple body site testing using agar and nutrient broth culture...
  18. doi Extranasal methicillin-resistant Staphylococcus aureus colonization at admission to an acute care Veterans Affairs hospital
    Stacey E Baker
    Veterans Affairs Boston Health Care System, Boston, Massachusetts 02130, USA
    Infect Control Hosp Epidemiol 31:42-6. 2010
    ..To evaluate the prevalence of and risk factors for extranasal methicillin-resistant Staphylococcus aureus (MRSA) colonization and its relationship to nasal colonization among veterans hospitalized for acute care...
  19. pmc Absence of livestock-associated methicillin-resistant staphylococcus aureus clonal complex CC398 as a nasal colonizer of pigs raised in an alternative system
    Christiane Cuny
    Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany
    Appl Environ Microbiol 78:1296-7. 2012
    ..Here we report a study on 25 farms adhering to an alternative system. LA-MRSA ST398 was not detected in nasal swabs from 178 pigs or from 89 humans working and living on these farms...
  20. doi The cellular orchestra in skin allergy; are differences to lung and nose relevant?
    Mubeccel Akdis
    2Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Curr Opin Allergy Clin Immunol 10:443-51. 2010
    ....
  21. pmc Objective display and discrimination of floral odors from Amorphophallus titanum, bloomed on different dates and at different locations, using an electronic nose
    Kouki Fujioka
    Department of Molecular Cell Biology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    Sensors (Basel) 12:2152-61. 2012
    ..Here we showed a virtual connection method between a human nose perceptions and electronic nose responses with the smell of standard gases...
  22. doi Morphometric and ultrastructural comparison of the olfactory system in elasmobranchs: the significance of structure-function relationships based on phylogeny and ecology
    Vera Schluessel
    School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
    J Morphol 269:1365-86. 2008
    ..This is the first comprehensive study comparing olfactory morphology to several aspects of elasmobranch ecology in a phylogenetic context...
  23. pmc Improved classification of Orthosiphon stamineus by data fusion of electronic nose and tongue sensors
    Ammar Zakaria
    Sensor Technology and Applications Group STAG, Universiti Malaysia Perlis UniMAP, 01000, Kangar, Perlis, Malaysia
    Sensors (Basel) 10:8782-96. 2010
    ..Five different commercial sources along with freshly prepared samples were discriminated using an electronic nose (e-nose) and an electronic tongue (e-tongue)...
  24. doi Retro-nasal aroma release depends on both subject and product differences: a link to food intake regulation?
    Rianne M A J Ruijschop
    NIZO Food Research, Ede, The Netherlands
    Chem Senses 34:395-403. 2009
    ..Interestingly, a negative trend was observed between extent of retro-nasal aroma release and amount of ad libitum food intake (P = 0.07). This may have implications for the regulation of food intake...
  25. doi Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001-2004
    Rachel J Gorwitz
    National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 197:1226-34. 2008
    ..Staphylococcus aureus is a common cause of infection, particularly in persons colonized by this organism. Virulent strains of methicillin-resistant S. aureus (MRSA) have emerged in the general community...
  26. doi Colonization of residents and staff of a long-term-care facility and adjacent acute-care hospital geriatric unit by multiresistant bacteria
    A March
    Reparto di Geriatria, Comprensorio Sanitario di Bolzano, Bolzano, Italy
    Clin Microbiol Infect 16:934-44. 2010
    ..Education of LTCF employees and better infection control are proposed to minimize the spread of resistant bacteria in the facility...
  27. pmc Temperature-dependent growth of Geomyces destructans, the fungus that causes bat white-nose syndrome
    Michelle L Verant
    Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 7:e46280. 2012
    White-nose syndrome (WNS) is an emergent disease estimated to have killed over five million North American bats. Caused by the psychrophilic fungus Geomyces destructans, WNS specifically affects bats during hibernation...
  28. ncbi Throat swabs are necessary to reliably detect carriers of Staphylococcus aureus
    Dominik Mertz
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Clin Infect Dis 45:475-7. 2007
    ..A total of 37.1% of persons were nasal carriers, and 12.8% were solely throat carriers. Screening of throat swabs significantly increases the sensitivity of detection among carriers by 25.7%...
  29. doi Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose
    Kristin Dauner
    Department of Molecular Physiology, Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Cell Tissue Res 347:327-41. 2012
    Calcium-activated chloride channels are expressed in chemosensory neurons of the nose and contribute to secretory processes and sensory signal transduction...
  30. ncbi The prevalence of methicillin-resistant staphylococci in healthy horses in the Netherlands
    J F Busscher
    Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
    Vet Microbiol 113:131-6. 2006
    ..Samples were taken from the nose and the pastern of the horses and from the nose and throat of the humans and incubated in selective media...
  31. pmc Regulatory adaptation of Staphylococcus aureus during nasal colonization of humans
    Marc Burian
    Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Universitat Tubingen, Tubingen, Germany
    PLoS ONE 5:e10040. 2010
    ..We quantified S. aureus mRNA levels in nose swabs of persistent carriers to gain insight into the regulatory adaptation of the bacterium to the nasal ..
  32. pmc Methicillin-resistant staphylococci in companion animals
    Keith E Baptiste
    University of Liverpool, Leahurst, United Kingdom
    Emerg Infect Dis 11:1942-4. 2005
    ..Methicillin-resistant Staphylococcus aureus (MRSA) identical to human EMRSA-15 was found in dogs and hospital staff. In contrast, 5 distinct MRSA strains were isolated from horses but not from hospital staff...
  33. pmc Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance
    I Narang
    Department of Paediatrics, Royal Brompton Hospital, Imperial School of Medicine, London SW3 6NP, UK
    Thorax 57:586-9. 2002
    ..The levels of exhaled and nasal nitric oxide (eNO and nNO) in groups of patients with inflammatory lung diseases are well documented but the diagnostic use of these measurements in an individual is unknown...
  34. ncbi The influence of head contour and nose angle on the perception of eye-gaze direction
    Stephen R H Langton
    Department of Psychology, University of Stirling, Stirling, Scotland, UK
    Percept Psychophys 66:752-71. 2004
    ..Finally, in Experiment 3A, nose angle was also found to influence participants' ability to discriminate direct gaze from averted gaze, but here the ..
  35. pmc Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies
    Catherine M McDougall
    School of Medicine, University of Aberdeen, Royal Aberdeen Children s Hospital, Aberdeen, UK
    Am J Respir Cell Mol Biol 39:560-8. 2008
    The nose is an attractive source of airway epithelial cells, particularly in populations in which bronchoscopy may not be possible...
  36. ncbi Prevalence of Staphylococcus aureus nasal colonization in the United States, 2001-2002
    Matthew J Kuehnert
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 193:172-9. 2006
    ..Although methicillin-resistant S. aureus (MRSA) infection has become increasingly reported, population-based S. aureus and MRSA colonization estimates are lacking...
  37. ncbi Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia
    Robin J Hennessy
    Stanley Research Unit, Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin
    Biol Psychiatry 61:1187-94. 2007
    ..The brain and face emerge in embryologic intimacy, such that in neurodevelopmental disorders, brain dysmorphogenesis is accompanied by facial dysmorphogenesis...
  38. ncbi A new intelligent electronic nose system for measuring and analysing livestock and poultry farm odours
    Leilei Pan
    School of Engineering, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Environ Monit Assess 135:399-408. 2007
    This paper introduces a new portable intelligent electronic nose system developed especially for measuring and analysing livestock and poultry farm odours. It can be used in both laboratory and field...
  39. pmc Mutations in the cystic fibrosis transmembrane regulator gene and in vivo transepithelial potentials
    Michael Wilschanski
    The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Am J Respir Crit Care Med 174:787-94. 2006
    ..To examine the relationship between cystic fibrosis transmembrane regulator gene mutations (CFTR) and in vivo transepithelial potentials...
  40. ncbi Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology
    LILIAN CALDERON-GARCIDUENAS
    Instituto Nacional de Pediatria, Mexico City, Mexico
    Toxicol Pathol 35:154-62. 2007
    ....
  41. pmc Pathology in euthermic bats with white nose syndrome suggests a natural manifestation of immune reconstitution inflammatory syndrome
    Carol U Meteyer
    National Wildlife Health Center, US Geological Survey, Madison, WI, USA
    Virulence 3:583-8. 2012
    White nose syndrome, caused by Geomyces destructans, has killed more than 5 million cave hibernating bats in eastern North America...
  42. ncbi Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)
    Martin Zenker
    Institute of Human Genetics, University of Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
    Nat Genet 37:1345-50. 2005
    ..Our findings indicate that deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway...
  43. pmc Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromsø Staph and Skin Study
    K Olsen
    Department of Microbiology and Infection Control, University Hospital of North Norway, 9038, Tromsø, Norway
    Eur J Clin Microbiol Infect Dis 31:465-73. 2012
    ..28-0.69) in the top tertile of serum 25(OH)D versus the bottom tertile. In women and smokers there were no such associations. Our study supports that serum vitamin D is a determinant of S. aureus colonization and carriage...
  44. pmc Prevalence of Staphylococcus aureus carriage among dogs and their owners
    M V Boost
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hung Hom, Kowloon, Hong Kong
    Epidemiol Infect 136:953-64. 2008
    ..29, 95% CI 1.49-7.26, P=0.002). In outbreak situations health-care workers' pets should be considered as a source of S. aureus. High rates of resistance indicate increased monitoring of antibiotic use in veterinary practice is needed...
  45. ncbi A gradient microarray electronic nose based on percolating SnO(2) nanowire sensing elements
    Victor V Sysoev
    Department of Physics, Saratov State Technical University, Saratov 410054, Russia
    Nano Lett 7:3182-8. 2007
    Fabrication, characterization, and tests of the practical gradient microarray electronic nose with SnO(2) nanowire gas-sensing elements are reported...
  46. pmc Evaluation of chromogenic media for detection of methicillin-resistant Staphylococcus aureus
    Surbhi Malhotra-Kumar
    Department of Medical Microbiology, Campus Drie Eiken, University of Antwerp, S3, Universiteitsplein 1, B 2610 Wilrijk, Antwerp, Belgium
    J Clin Microbiol 48:1040-6. 2010
    ..In conclusion, BBL-CHROMagar and CHROMagar gave the best overall results for detection of MRSA, irrespective of the sample concentration, investigator, or incubation period...
  47. ncbi A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
  48. pmc Host- and microbe determinants that may influence the success of S. aureus colonization
    Mona Johannessen
    Research Group of Host Microbe Interaction, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
    Front Cell Infect Microbiol 2:56. 2012
    ..The major site of colonization is the nose, i.e., the vestibulum nasi, which is covered with ordinary skin and hair follicles...
  49. pmc Survival of Staphylococcus aureus ST398 in the human nose after artificial inoculation
    Bibi C G C Slingerland
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e48896. 2012
    There is evidence that MRSA ST398 of animal origin is only capable of temporarily occupying the human nose, and it is therefore, often considered a poor human colonizer...
  50. doi A new method for scintigraphic quantification of deposition and clearance in anatomical regions of the human nose
    Arne Skretting
    Department of Medical Physics, Clinic of Oncology and Radiotherapy, Rikshospitalet University Hospital, Oslo, Norway
    Nucl Med Commun 30:629-38. 2009
    ..for absolute quantification of the deposition of 99mTc-labeled aerosols and powders in well-defined anatomical regions of the nose, and to enable accurate comparisons of different nasal administration techniques in the same individual.
  51. pmc Genetic diversity and ecological success of Staphylococcus aureus strains colonizing humans
    Olga Sakwinska
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    Appl Environ Microbiol 75:175-83. 2009
    ..Alternatively, carrier characteristics other than those evaluated here or factors other than human hosts may exert selective pressure maintaining genotypic clusters...
  52. ncbi New concepts in nasal tip contouring
    Dean M Toriumi
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology Head and Neck Surgery, University of Illinois at Chicago, 60612, USA
    Arch Facial Plast Surg 8:156-85. 2006
    ..Prior to contouring the nasal tip, the surgeon must stabilize the base of the nose with a columellar strut, suturing the medial crura to a long caudal septum, caudal extension graft, or an extended ..
  53. doi Staphylococcus aureus nasal carriage might be associated with vitamin D receptor polymorphisms in type 1 diabetes
    Charalambos Panierakis
    Department of Pediatrics, University of Crete, POB 2208, Heraklion 71003, Greece
    Int J Infect Dis 13:e437-43. 2009
    ..In this study we investigated whether VDR gene polymorphisms influence nasal carriage of Staphylococcus aureus in individuals with T1D...
  54. ncbi A code in the nose
    Stuart Firestein
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Sci STKE 2004:pe15. 2004
    The mammalian nose is arguably the best chemical detector on the planet, capable of detecting and discriminating among many thousands of compounds...
  55. ncbi The role of the ear, nose and throat specialist in diagnosing headaches
    G Felisati
    Clinic of Otorhinolaryngology, ENT Department, San Paolo Hospital, University of Milan, Via di Rudini 8, I 20080, Milan, Italy
    Neurol Sci 26:s83-6. 2005
    The revised International Headache Society classification (2004) represents a very good reference also for ear, nose and throat (ENT) specialists and can be largely shared...
  56. pmc cAMP-independent responses of olfactory neurons in Xenopus laevis tadpoles and their projection onto olfactory bulb neurons
    Ivan Manzini
    Physiologisches Institut, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 545:475-84. 2002
    ..amino acid stimuli on the other was further elucidated by calcium-imaging of olfactory bulb neurons using a novel nose-olfactory bulb preparation of Xenopus laevis tadpoles...
  57. ncbi Evaluation of nasal airway resistance during rapid maxillary expansion using acoustic rhinometry
    Cenk Doruk
    Department of Orthodontics, Cumhuriyet University, Sivas, Turkey
    Eur J Orthod 26:397-401. 2004
    ..05). The use of a decongestant was not found to have any effect on the results. Subjective evaluation showed that 59 per cent of patients considered that their nasal breathing had improved following RME...
  58. doi Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed?
    N J P Ten Broeke-Smits
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hosp Infect 76:211-4. 2010
    ..aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S...
  59. ncbi Ear, nose and throat foreign bodies in Melanesian children: an analysis of 1037 cases
    Sam Endican
    Department of Ear, Nose and Throat, Port Moresby General Hospital, Papua New Guinea
    Int J Pediatr Otorhinolaryngol 70:1539-45. 2006
    Occurrence of foreign bodies (FBs) in ear, nose and throat (ENT) in children are not uncommon in clinical practice. We described our experience with ENT foreign bodies in Melanesian children.
  60. pmc Nasal carriage of methicillin-resistant Staphylococcus aureus is associated with higher all-cause mortality in hemodialysis patients
    Chun Fu Lai
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Clin J Am Soc Nephrol 6:167-74. 2011
    ..However, the association between MRSA carriage and patient survival in hemodialysis patients has not been established...
  61. ncbi Staphylococcus aureus nasal carriage is not associated with known polymorphism in the Vitamin D receptor gene
    Mark Claassen
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 43:173-6. 2005
    ..Our study into genetic determinants of S. aureus carriage patterns is the largest in the field, but still we found no association between VDR gene variation and S. aureus nasal carriage...
  62. ncbi Skeletal and occlusal characteristics in mouth-breathing pre-school children
    Sara Elisa M Mattar
    Department of Pediatric Dentistry, School of Dentistry, University of Uberaba, Brazil
    J Clin Pediatr Dent 28:315-8. 2004
    ..Based on the results of this study, mouth-breathing can influence craniofacial and occlusal development early in childhood...
  63. pmc Persistent nasal carriage of Staphylococcus aureus is associated with deficient induction of human beta-defensin 3 after sterile wounding of healthy skin in vivo
    Philipp Zanger
    Institut fur Tropenmedizin, Eberhard Karls Universitat, Tübingen 72074, Germany
    Infect Immun 79:2658-62. 2011
    ..In conjunction with existing knowledge, these findings suggest that healthy individuals with deficient HBD-3 expression in keratinocytes are more prone to persistent nasal colonization with S. aureus...
  64. ncbi Numerical simulation of air temperature and airflow patterns in the human nose during expiration
    D Pless
    Department of Diagnostic Radiology, University of Ulm, Ulm, Germany
    Clin Otolaryngol Allied Sci 29:642-7. 2004
    Recovery of heat and water during expiration is an important but not yet fully understood function of the nose. The presented study investigated cooling of the expiratory air for heat recovery within the human nose applying numerical ..
  65. ncbi Simultaneous real-time measurements of mastication, swallowing, nasal airflow, and aroma release
    M Hodgson
    Division of Food Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK
    J Agric Food Chem 51:5052-7. 2003
    ..measured simultaneously in vivo using electromyography, electroglottography, a turbine air flow meter, and the MS-Nose, respectively...
  66. ncbi Prevalence of nasal colonization among patients with community-associated methicillin-resistant Staphylococcus aureus infection and their household contacts
    Uzma Zafar
    Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI, USA
    Infect Control Hosp Epidemiol 28:966-9. 2007
    ..To evaluate the prevalence of colonization among patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection and their household contacts...
  67. ncbi The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants
    H M Janssens
    Department of Pediatric Pulmonology, Sophia Children's Hospital/Erasmus Medical Centre Rotterdam, The Netherlands
    J Aerosol Med 14:433-41. 2001
    ..This model will be used to obtain insight in aerosol treatment that cannot be obtained in vivo...
  68. ncbi The nose and paranasal sinuses physiology and anatomy
    N Jones
    University Hospital, NG7 2UH, Nottingham, UK
    Adv Drug Deliv Rev 51:5-19. 2001
    The paranasal sinuses and nose are much more than two cavities behind a projection on the centre of the face. They humidify, filter, warm, and sense what we breathe. The anatomy and physiology interact forming a dynamic system...
  69. pmc Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans
    Alex van Belkum
    University Medical Center Rotterdam, Rotterdam, The Netherlands
    Emerg Infect Dis 14:479-83. 2008
    ..aureus circulates among humans at low frequency (0.2%) but was isolated in 3 human cases of bacteremia (2.1%; p = 0.026). Although its natural host is probably porcine, ST398 MRSA likely causes infections in humans...
  70. pmc The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin
    Matt S Conover
    Program in Molecular Genetics, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Mol Microbiol 77:1439-55. 2010
    ..We show that the Bps polysaccharide of B. pertussis is critical for initial colonization of the mouse nose and the trachea but not of the lungs. Our data reveal a biofilm lifestyle for B...
  71. doi Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus
    Francois Barbier
    Bacteriology Unit and National Reference Center for Emergence of Resistance in Commensal Flora, 2EA 3964, Bichat Claude Bernard Hospital, Assistance Publique Hôpitaux de Paris and Xavier Bichat Medical School, Denis Diderot Paris 7 University, Paris, France
    J Infect Dis 202:270-81. 2010
    ..We assessed their potential role as a reservoir of staphylococcal cassette chromosome mec (SCCmec) IVa, the leading SCCmec subtype in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)...
  72. pmc Comparison of combined nose-throat swabs with nasopharyngeal aspirates for detection of pandemic influenza A/H1N1 2009 virus by real-time reverse transcriptase PCR
    Victoria Ortiz de la Tabla
    Microbiology Service, Hospital Universitario de San Juan, Alicante, Spain
    J Clin Microbiol 48:3492-5. 2010
    ..The objective of this study was to compare the sensitivity of combined nose and throat swabs (CNTS) with that of nasopharyngeal aspirates (NPA)...
  73. pmc Evolution of nasal carriage of methicillin-resistant coagulase-negative staphylococci in a remote population
    David Lebeaux
    Bacteriology Unit and French National Reference Center for Bacterial Resistance in Commensal Flora, Diderot Paris 7 University and Bichat Claude Bernard Teaching Hospital Assistance Publique Hôpitaux de Paris, Paris, France
    Antimicrob Agents Chemother 56:315-23. 2012
    ....
  74. pmc Bacterial community variation in human body habitats across space and time
    Elizabeth K Costello
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
    Science 326:1694-7. 2009
    ..These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease...
  75. doi Staphylococcus pseudintermedius colonization patterns and strain diversity in healthy dogs: a cross-sectional and longitudinal study
    Narayan Chandra Paul
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Vet Microbiol 160:420-7. 2012
    ..The most frequent carriage sites were the perineum (66%) and the mouth (65%) followed by the nose (27%) and the groin (23%)...
  76. doi Ultrasensitive flexible graphene based field-effect transistor (FET)-type bioelectronic nose
    Seon Joo Park
    World Class University program of Chemical Convergence for Energy and Environment, School of Chemical and Biological Engineering, Seoul National University, Seoul 151 742, Korea
    Nano Lett 12:5082-90. 2012
    ..demonstrate an ultrasensitive and flexible field-effect transistor (FET) olfactory system, namely, a bioelectronic nose (B-nose), based on plasma-treated bilayer graphene conjugated with an olfactory receptor...
  77. doi Nasally inhaled pulsating aerosols: lung, sinus and nose deposition
    W Moller
    Institute for Lung Biology and Disease, German Research Center for Environmental Health, Neuherberg, Germany
    Rhinology 49:286-91. 2011
    ..to investigate 1) the delivery efficiency of a pulsating aerosol (Vibrent prototype device) to the sinuses and the nose, 2) the aerosol fraction that will deposit in the lungs and 3) potential differences regarding sinus and nasal ..
  78. pmc Methicillin-resistant Staphylococcus aureus infection or colonization present at hospital admission: multivariable risk factor screening to increase efficiency of surveillance culturing
    Clinton C Haley
    Department of Internal Medicine, Austin Medical Education Programs, Brackenridge Hospital, 601 E 15th Street, Austin, Texas 78701, USA
    J Clin Microbiol 45:3031-8. 2007
    ..If confirmed in additional studies, multivariable questionnaire screening at admission might identify a subset of admissions for surveillance cultures that would more efficiently identify most admission MRSA...
  79. ncbi Morphological variation and airflow dynamics in the human nose
    Steven E Churchill
    Department of Biological Anthropology and Anatomy, Duke University, Durham, North Carolina 27708, USA
    Am J Hum Biol 16:625-38. 2004
    Airflow dynamics are recognized as being important to the functioning of the human nose in conditioning and filtering inspired air, yet these dynamics are poorly understood...
  80. doi Long-term use and follow-up of irradiated homologous costal cartilage grafts in the nose
    Russell W H Kridel
    Facial Plastic Surgery Associates, 6655 Travis, Ste 900, Houston, TX 77030, USA
    Arch Facial Plast Surg 11:378-94. 2009
    ..and Neck Surgery) on the use of irradiated homologous costal cartilage (IHCC) or homograft cartilage in the nose. This is a follow-up study to share our experience in answering fundamental questions: (1) What are the major long-..
  81. ncbi Foreign bodies in the aerodigestive tract in pediatric patients
    Ryuzaburo Higo
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 3 1, Hongo 7 chome, Bunkyo ku, 113 8655, Tokyo, Japan
    Auris Nasus Larynx 30:397-401. 2003
    ..To investigate pediatric foreign body cases in the aerodigestive tract, and to elucidate the characteristic problems in Japan...
  82. ncbi Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study
    M W H Wulf
    Department of Medical Microbiology, Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Microbiol Infect 14:29-34. 2008
    ..participants at an international conference on pig health in Denmark was screened for MRSA carriage using combined nose/throat swabs and were asked to complete a questionnaire concerning animal contacts, exposure to known MRSA risk-..
  83. ncbi Phylogenic aspects of the amphibian dual olfactory system
    Kazumi Taniguchi
    Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato University, Towada, Japan
    J Vet Med Sci 70:1-9. 2008
    ....
  84. ncbi The Cotton Rat as a Model for Staphylococcus aureus nasal colonization in humans: cotton rat S. aureus nasal colonization model
    John F Kokai-Kun
    Biosynexus Incorporated, Gaithersburg, MD, USA
    Methods Mol Biol 431:241-54. 2008
    ..aureus nasal colonization is enumerated by surgical removal of the nose and recovery of the colonizing S. aureus...
  85. ncbi High phenotypic diversity in infecting but not in colonizing Staphylococcus aureus populations
    Christiane Goerke
    Institute for Medical Microbiology and Hygiene, University Hospital Tubingen, Tubingen, Germany
    Environ Microbiol 9:3134-42. 2007
    ..of phenotypic variants (differences in haemolysis, pigmentation, colony morphology) in primary cultures from nose, oropharyngeal and sputum specimens from cystic fibrosis (CF) patients and in nose swabs from healthy S...
  86. doi Maxillofacial prosthetic rehabilitation using extraoral implants
    Alessandra Leonardi
    II Faculty of Medicine and Surgery, University of Rome La Sapienza Azienda Ospedaliera S Andrea, Maxillo facial Surgery, Via di Grottarossa, Rome, Italy
    J Craniofac Surg 19:398-405. 2008
    ..with hepatitis C virus, with an important parodontal disease, who experienced a postinfective necrosis of the nose after a liver transplantation; it was necessary to place an adhesive prosthesis...
  87. pmc Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults
    Heiman F L Wertheim
    Erasmus MC, University Hospital Rotterdam, Department of Clinical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:1465-7. 2005
    ..The finding warrants the use of mupirocin only in proven carriers for decolonization purposes. Mupirocin is effective overall in decolonizing nasal carriers but less effective in decolonizing extranasal sites...
  88. pmc From nose to lung: the regulation behind Streptococcus pneumoniae virulence factors
    David L Hava
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Microbiol 50:1103-10. 2003
    ..These studies add to the foundation of knowledge of classical S. pneumoniae virulence factors such as polysaccharide capsule and pneumolysin, which have well-documented roles in pathogenesis...
  89. ncbi Numerical modeling of turbulent and laminar airflow and odorant transport during sniffing in the human and rat nose
    Kai Zhao
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 31:107-18. 2006
    ..In rat nose odorant uptake simulations, it was observed that odorant deposition was highly dependent on solubility and ..
  90. ncbi Association between nasal carriage of Staphylococcus aureus and the human complement cascade activator serine protease C1 inhibitor (C1INH) valine vs. methionine polymorphism at amino acid position 480
    Marieke Emonts
    Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 50:330-2. 2007
    ..52, P=0.02). These findings suggest that susceptibility to S. aureus nasal carriage is associated with the C1INH V480M polymorphism...
  91. doi Simulated head related transfer function of the phyllostomid bat Phyllostomus discolor
    F De Mey
    Department Milieu, Technologie en Technologiemanagement, Universiteit Antwerpen, Prinsstraat 13, 2000 Antwerpen, Belgium
    J Acoust Soc Am 124:2123-32. 2008
    ..From the calculated HRTF results, binaural interaural intensity differences (IIDs) are derived...
  92. ncbi Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections
    Trish M Perl
    University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
    N Engl J Med 346:1871-7. 2002
    ..Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections...
  93. pmc Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital Department of Virology, University of Turku, Turku, Finland
    J Clin Microbiol 40:4337-9. 2002
    ..The sensitivity of nasal swabs was comparable to that of nasopharyngeal aspirates for the detection of all major respiratory viruses except respiratory syncytial virus...
  94. pmc Different regulation of cigarette smoke induced inflammation in upper versus lower airways
    Wouter Huvenne
    Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent University, Belgium
    Respir Res 11:100. 2010
    ..We investigated and compared the effects of CS on upper and lower airways, in a mouse model of subacute and chronic CS exposure...
  95. doi Comparative outcomes of two nasoalveolar molding techniques for unilateral cleft nose deformity
    Yu Fang Liao
    Craniofacial Center and the Craniofacial Research Center, Chang Gung Memorial Hospital, Taoyuan, Gueishan Township Taiwan
    Plast Reconstr Surg 130:1289-95. 2012
    Nasoalveolar molding is increasingly being used to treat unilateral cleft nose deformity before primary repair...
  96. ncbi Drug delivery systems from nose to brain
    Ambikanandan Misra
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Kalabhavan, Vadodara, India
    Curr Pharm Biotechnol 13:2355-79. 2012
    ..discusses the potential of intranasal route to deliver drugs to the brain, the mechanisms and pathways of direct nose to brain drug transport, the various factors influencing transnasal drug absorption, the conventional and novel ..
  97. doi Mimicking the human smell sensing mechanism with an artificial nose platform
    Sang Hun Lee
    School of Chemical and Biological Engineering, Bio max Institute, Seoul National University, Seoul 151 742, Republic of Korea
    Biomaterials 33:1722-9. 2012
    ..Herein, we report a highly sensitive and selective human nose-like nanobioelectronic nose (nbe-nose), which responds to gaseous odorants sensitively and selectively, has a ..
  98. ncbi Foreign bodies in the ear, nose, and throat
    Steven W Heim
    University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am Fam Physician 76:1185-9. 2007
    Foreign bodies in the ear, nose, and throat are occasionally seen in family medicine, usually in children. The most common foreign bodies are food, plastic toys, and small household items...
  99. ncbi A U.S. population-based survey of Staphylococcus aureus colonization
    Philip L Graham
    Department of Pediatrics, Columbia University and New York Presbyterian Medical Center, New York, New York 10032, USA
    Ann Intern Med 144:318-25. 2006
    ..The epidemiology of staphylococcal colonization and community-associated methicillin-resistant Staphylococcus aureus (MRSA) is changing, and little is known from the national perspective...
  100. pmc Characterization and persistence of Staphylococcus aureus strains isolated from the anterior nares and throats of healthy carriers in a Mexican community
    Aída Hamdan-Partida
    Departamento de Sistemas Biologicos, Universidad Autonoma Metropolitana Xochimilco, Calz del Hueso 1100, Col Villa Quietud, Coyoacan 04960, Mexico City, Mexico
    J Clin Microbiol 48:1701-5. 2010
    ..aureus was examined. This study showed that some strains of S. aureus regularly colonized the throats of healthy people and could persist for years...
  101. doi Surgical technique for secondary correction of unilateral cleft lip-nose deformity: clinical and 3-dimensional observations of preoperative and postoperative nasal forms
    Norifumi Nakamura
    Department of Oral and Maxillofacial Surgery, Field of Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Oral Maxillofac Surg 68:2248-57. 2010
    Despite recent developments in cleft surgery, a surgical method for secondary correction of unilateral cleft lip-nose deformity has not yet been established...

Research Grants74

  1. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ..of promising emerging diagnostic tools for TB, including the Xpert MTB/RIF using real-time PCR, the electronic nose, a non-invasive technology based on detection of volatile compounds, and a modified cytokine-based serological ..
  2. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..expression changes from invasive samples taken from the bronchi (lower airways) and non- invasive samples from the nose (upper airways) have shown many similarities...
  3. Durable Visible Light-activated Antivral Coatings for Fabrics Used for Personal P
    JOSEF STEPHAN SCHNEIDER; Fiscal Year: 2011
    ..Influenza enters the body through the nose or throat...
  4. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..Non-invasive intranasal nose-to-brain delivery offers faster delivery of therapeutics to the brain...
  5. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..Aim 2. Test the hypothesis that sensory input to the nose during the postnatal period affects TRPM5 expression in OSNs Aim 3...
  6. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..cause fatal disease of the internal organs as well as non-healing and disfiguring diseases of the skin, mouth, and nose. Drug therapies for leishmaniasis have severe side effects and are losing their curative effect, and no practical ..
  7. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..The allergic sensitization model, which relies on particle and OVA aspiration from the nose of anesthesized animals, will assess OVA-specific IgE levels in parallel with BAL differential cell counts and lung ..
  8. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..Similar mobile zinc stores present in the olfactory bulb (OB) process odorant information trans- mitted from the nose in a more direct signaling pathway...
  9. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2013
    ..treatment for sleep apnea is continuous positive airway pressure (CPAP) which consists of a mask applied to the nose and a blower that blows air under pressure...
  10. Characterization of Chd7 in central nervous system neural stem cells
    JOSEPH ANTHONY MICUCCI; Fiscal Year: 2013
    ..in CHD7 cause CHARGE Syndrome, a multiple congenital anomaly disorder that affects development of the eyes, ears, nose, and central nervous system (CNS)...
  11. Combined Computational and Wet Lab Screening for Drugs Tested via OATs
    Sanjay K Nigam; Fiscal Year: 2010
    ..Because of the expression of Oat6 and Oat1 at the so- called nose-brain barrier and specific substrate preferences, the pathway is attractive for a side-by-side in silico and wet ..
  12. Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
    TIRUNELVELI RAMALINGAM; Fiscal Year: 2013
    ..Flexible fiber-optic or rigid endoscopes are normally inserted through the nose or into the pharynx for conventional physical examinations, but endoscopy alone cannot be used to differentiate ..
  13. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2013
    ..receiving secondary palatal surgery for speech who have cleft palate;3. receiving secondary lip/nose revisions for facial appearance;and 4. receiving alveolar bone grafts for dental development...
  14. Validation of a Genomic Biomarker of Response to Environmental Tobacco Smoke
    AVRUM E SPIRA; Fiscal Year: 2012
    ..biomarkers to assess the biologic response to SHS by profiling cells that can be collected from the mouth or nose using minimally invasive procedures...
  15. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..of particular interest as it serves functional and structural roles, including the support of soft tissue (ear and nose), airway patency (trachea), phonation (larynx), and joint movement (i.e.,TMJ)...
  16. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2012
    ..Chemicals and biological agents were administered by whole-body inhalation, nose-only inhalation, intratracheal instillation, oropharyngeal aspiration, intraperitoneal injection, and intrapleural ..
  17. In Vivo Measures of Vocal Function Response to Environmental Conditions
    MARY JOYCE SANDAGE; Fiscal Year: 2012
    ..humidity influence phonatory onset, regional laryngeal temperature, and perception of vocal ease for mouth versus nose inhalation using a within-subject repeated measures design...
  18. Identification and Characterization of New Genes Required for Cilia Motility
    Jennifer R Panizzi; Fiscal Year: 2010
    ..These embryos are characterized by a curved body axis, immotile cilia in the nose, kidneys, spinal canal, and develop kidney cysts within 3 days post-fertilization...
  19. Role of the Indoor Environment on Oxidative Stress Related Sinonasal Inflammation
    Murugappan Ramanathan; Fiscal Year: 2013
    ..This proposal will study the role of a critical pathway that may regulate environmentally induced inflammation in the nose and sinus and may ultimately lead to more effective therapies for chronic sinusitis.
  20. Nicotine delivery to rodent with lung alveolar region-targeted aerosol technology
    Xinmin Simon Xie; Fiscal Year: 2013
    ..In both the nose-only device and free-moving exposure chambers, the aerosol droplet size distribution is within the respirable ..
  21. Tissue Engineering of a Neotrachea
    James E Dennis; Fiscal Year: 2013
    ..with the optimization study of rabbit chondrocytes, human chondrocytes will be obtained from the trachea, ear, nose and from articular surfaces and will be optimized for cartilage sheet formation by first testing a bank of growth ..
  22. FGF Regulation of GnRH Neurons
    PEISAN TSAI; Fiscal Year: 2012
    ..During embryogenesis, these cells first arise in the nose and then migrate to the brain where they eventually settle and assume their function...
  23. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2012
    ..mammals, volatile odorants are detected by olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) of the nose. In response to odorants, OSNs transmit signals to the olfactory bulb (OB) of the brain, which relays signals to ..
  24. Annual Estimates of Influenza Vaccine Effectiveness: Davidson County, TN
    Marie R Griffin; Fiscal Year: 2010
    ..Enrolled subjects will contribute nose and throat swabs for influenza testing in the research laboratory...
  25. Therapeutic Effect of Intranasal Insulin on Cognition, Function, and AD Biomarker
    Suzanne Craft; Fiscal Year: 2013
    ..Intranasal insulin will be administered with the use of an innovative electronic atomizer designed to maximize nose-to-brain transport. Two-hundred and forty participants with aMCI (Petersen criteria, Clinical Dementia Rating/CDR 0...
  26. Leishmaniasis Drug Development Using an Evolutionary Design Strategy
    Roger G Linington; Fiscal Year: 2010
    ..form of the disease these include ulcerative skin lesions and the destruction of the mucous membranes of the nose, mouth and throat leading to permanent disfigurement;however it is the visceral form of the disease that represents ..
  27. Decreasing Bioburden to Reduce Healthcare-Associated Infections and Readmissions
    Susan S Huang; Fiscal Year: 2013
    ..Most infections result from common bacteria that normally live on the skin or in the nose and which overcome the body's normal defenses because of invasive medical devices, surgical incisions, or the ..
  28. Second-generation Gene Transfer Vector-based Anti-cocaine Vaccines
    Ronald G Crystal; Fiscal Year: 2013
    ..An AAV coding for anti-cocaine will also be administered to the nose to determine if high titer anti-cocaine antibodies at the site of entry can aid as a 1st anti-cocaine defense.
  29. Recurrent MRSA Infections: A Study of Risk Factors and Molecular Epidemiology
    MICHAEL ZDENEK DAVID; Fiscal Year: 2013
    ..MRSA is often a commensal organism, living on the skin, in the gastrointestinal tract, and in the nose of individuals, and asymptomatic carriage is thought to be common before an infection occurs...
  30. Celecoxib Derivative: Host Cell-Directed Inhibitors of Intracellular Pathogens
    Kristy M Ainslie; Fiscal Year: 2013
    ..macrophages (500-1,000 nm);2) a porous microparticle (PMP) that is ideal size (5-15 mm) for inhalation via the nose (i.n.) and penetration to the nasal associated lymphoid tissue (NALT)...
  31. Naloxone prescription for Opioid Safety Evaluation (NOSE)
    Phillip O Coffin; Fiscal Year: 2013
    ..Finally, an assessment of the validity of EMR data for evaluating this program will be conducted, comparing results by ICD-9 coding to direct chart review of patient emergency department visits. ..
  32. TSLP and the Pathophysiology of Asthma
    Steven F Ziegler; Fiscal Year: 2013
    ..TSLP action is not limited to the skin - it has also been implicated in allergic responses in the lung and the nose, thus making it a common element in atopic diseases...
  33. Core_plus Option_B_C_Influenza Vaccine Effectiveness in a Wisconsin Population
    Edward Belongia; Fiscal Year: 2013
    ..After obtaining informed consent, nose and throat swabs will be tested for influenza A and B using a nucleic acid amplification test (RT-PCR)...
  34. IMpact of PRObiotics for reducing infections in VEterans: The IMPROVE Study
    Nasia Safdar; Fiscal Year: 2013
    ..Middleton Memorial Veterans Hospital, Madison WI who are colonized with S. aureus in the nose, gastrointestinal site, or both...
  35. Understanding the function of trace amine-associated (TAARs)
    Kyoung hye Yoon; Fiscal Year: 2013
    ..mammals, odorants are detected by olfactory sensory neurons (OSNs) that line the olfactory epithelium (OE) of the nose. OSNs express olfactory receptors, which are G protein-coupled receptors specialized in detecting odors...
  36. EGFR-targeted Polymeric Micelles for Targeted Pc 4-PDT of Oropharyngeal Tumors
    ALYSSA MANECK MASTER; Fiscal Year: 2013
    ..Cancers of the buccal cavity, head and neck subset, larynx, pharynx, and nose/nasal passages is the seventh most common cause of cancer death in the US...
  37. Nitric Oxide-Releasing Intranasal Gel To Decolonize Biofilm-embedded S. Aureus
    SUSANNE BAUMAN; Fiscal Year: 2012
    ..aureus in their nose without experiencing any symptoms. Despite the lack of symptoms, nasal carriage of S...
  38. Olfactory Singaling, Cilia, and Sensory Disorders
    JEFFREY MARTENS; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE In the nose, neurons involved in smell have many cilia, hair-like projections into the nasal cavity, which contain all of the ..
  39. Central Nervous System Delivery of Opioid Peptides
    JOHN HOEKMAN; Fiscal Year: 2012
    ..barrier (BBB) and deliver drugs directly to the brain via the olfactory connections in the upper nasal cavity ("nose-to-brain" delivery)...
  40. Virtual tool to address facial appearance transfer in face transplantation
    Bohdan Pomahac; Fiscal Year: 2012
    ..The transplanted tissues may include nose, lips, teeth, skin, bone, blood vessels, muscles and nerves, among others...
  41. Modulation of Olfactory Cilia
    Minghong Ma; Fiscal Year: 2013
    ..of odorants to specific odorant receptors (ORs) located in the cilia of olfactory sensory neurons (OSNs) in the nose. The mouse olfactory epithelium harbors several million OSNs, each of which expresses one type of OR out of a ..
  42. Craniofacial Gene Discovery in Mice
    Leah Rae B Donahue; Fiscal Year: 2010
    ..They are: a) Nm3768, a semi-dominant mutation displaying preaxial polydactlyly, a short nose, dorsal alopecia, abnormal frontal bone development, and eyes open at birth;b) Nm3437, a semi-dominant mutation ..
  43. A Sensory Map for Sulfated Steroids in the Accessory Olfactory Bulb
    Gary Hammen; Fiscal Year: 2013
    ..Sensory neurons in the nose project to the accessory olfactory bulb, where axons from neurons expressing the same receptor type co-converge on ..
  44. Optical Imaging of Olfactory Sensory Code Transformation
    Shin Nagayama; Fiscal Year: 2012
    ..population codes, and ask what is the benefit of redistributing odor signals which have just converged via the nose-to-bulb projection...
  45. Design, evaluation, and validation of a next-generation inhalable aerosol sampler
    John Volckens; Fiscal Year: 2013
    ..As such, the sampler will capture particles with the same efficiency as a worker's mouth and nose. This research will: (a) use computational fluid dynamics modeling tools to investigate how inlet geometries affect ..
  46. Low-Cost Electronic Nose for Groundwater Contaminants
    Sanjay Patel; Fiscal Year: 2009
    ..The proposed work will focus on detection of chlorinated hydrocarbons, which are described as among the most common pollutants in groundwater and soils at DOE sites. ..
  47. Olfactory Proteins in the Kidney and Regulation of Glomerular Filtration Rate
    Jennifer L Pluznick; Fiscal Year: 2010
    ..We have found that the same proteins in your nose which allow you to smell are also present in the cells in your kidney which are responsible for monitoring urine ..
  48. Immune Responses of the Epithelium in Chronic Rhinosinusitis with Polyps
    Andrew P Lane; Fiscal Year: 2013
    ..The cellular and molecular mechanisms that underlie CRSwNP remain poorly understood. The epithelium of nose and sinuses participates actively in host immunity, serving as a barrier and first line of defense against inhaled ..
  49. Mechanisms of Species-Dependent Environmental Lung Injury
    Edward M Postlethwait; Fiscal Year: 2010
    ..response determinants as a function of acute versus episodic exposures;develop lung injury biomarkers utilizing the nose as a sentinel;build structural atlases extracted from 3-D reconstructions, and, formulate models that predict ..
  50. Spread of Community-Acquired MRSA Among Household Contacts
    Robert S Daum; Fiscal Year: 2010
    ..The predominant site of CA-MRSA will also be determined by culturing both the nose and the hand...
  51. CELLULAR AND MOLECULAR MECHANISMS OF OLFACTORY CODING
    JOHN J NGAI; Fiscal Year: 2010
    ..These chemical cues are detected by receptors expressed in the primary sensory neurons of the nose. The studies proposed in the present application will investigate the principles underlying chemical recognition by ..
  52. Ectodermal Placode Development into Sensory Structures
    Marianne Bronner; Fiscal Year: 2013
    ..delaminate to give rise to portions of the cranial ganglia as well as sensory structures like the ear, lens, and nose. While peripheral ganglia of the trunk are exclusively neural crest-derived, those arising at cranial levels have a ..
  53. The UCLA - Boston University Lung Cancer Biomarker Development Laboratory
    AVRUM E SPIRA; Fiscal Year: 2013
    ..allow for the detection of early stage lung cancer in non-invasively collected biospecimens, including the mouth, nose and blood...
  54. How vesicles send information to retinal ganglion cells
    Michael A Freed; Fiscal Year: 2012
    ..Gap junctions between horizontal cells improve signal-to-nose ratio. Thresholding at the rod ? rod bipolar synapse rejects noise generated in rods...
  55. Low-Cost Electronic Nose for Groundwater Contaminants
    Sanjay V Patel; Fiscal Year: 2012
    ..The proposed work will focus on detection of chlorinated hydrocarbons, which are described as among the most common pollutants in groundwater and soils at DOE sites. ..
  56. FUNCTIONS OF PACAP IN OLFACTORY NEURONS
    Mary Lucero; Fiscal Year: 2009
    ..This process occurs in the olfactory epithelium (OE) lining the nose and involves the step-wise transformation of mitotic basal ("stem") cells into differentiated mature ORNs...
  57. Antibiotics from nose and throat commensals that impact pathogen colonization
    KATHERINE PAIGE LEMON; Fiscal Year: 2013
    ..and intriguing clinical observation that is directly relevant to human health and concerns the dynamics of human nose and throat microbial communities: about 50% of individuals are not colonized with either Staphylococcus aureus or ..
  58. Array of Resistive Sensors for Detecting Lung Cancer in Exhaled Air
    KATHERINE ANDREA MIRICA; Fiscal Year: 2013
    ..This device is akin to an "electronic nose" that "smells" the characteristic odor of cancer from a person's breath...
  59. Somatosensory Factors in Human Taste and Flavor Perception
    Barry G Green; Fiscal Year: 2013
    ..Much of this function is carried-out by the sensory systems of the mouth and nose which together give rise to the flavor of foods...
  60. Aerosol Management Platform with Exposure Chamber
    William A Altemeier; Fiscal Year: 2010
    ..AeroMP controls aerosol exposure for up to 24 mice simultaneously via either the whole body exposure chamber or a nose-only InTox exposure system, which is already available in the Center for Lung Biology...
  61. Study of Asthma and Nasal Steriods
    Anne E Dixon; Fiscal Year: 2013
    ..An important factor that may contribute to poor asthma control is disease of the nose and sinuses...
  62. Sulfated Polysaccharide Derivatives for the Treatment of Rosacea
    NARAYANAM RAO; Fiscal Year: 2009
    ..Dry, itchy eyes are also common. In men, Rosacea can thicken the skin of the nose to create the classical "W.C. Fields" nose, or rhinophyma...
  63. Optimization of dipeptide-linked benzimidazole topoisomerase 1 poisons
    Craig Beeson; Fiscal Year: 2009
    ..We hypothesized that bifunctional agents that simultaneously bind to the DNA minor groove and the nose-cone region of the Top1 protein would be effective poisons with pharmaceutical properties that are superior to the ..
  64. INDIVIDUAL FACTORS IN NASAL IRRITANT SENSITIVITY
    Dennis Shusterman; Fiscal Year: 2002
    ..Adapted from the Investigator's Abstract): A variety of symptoms linked to indoor air pollution, including eye, nose, and throat irritation (as well as reflex nasal congestion, rhinorrhea, and sinus headache) are either mediated (or ..
  65. INTERPLAY OF ALLERGIC RHINITIS AND NASAL HUMIDIFICATION
    Robert Naclerio; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract and specific aims): The nose functions to warm and humidify inhaled air...
  66. NASAL IRRITANT SENSITIVITY AND ALLERGIC RHINITIS
    Dennis Shusterman; Fiscal Year: 2000
    Eye, nose and throat irritation (trigeminally mediated sensations) comprise the most frequently reported acute symptoms among individuals exposed to environmental tobacco smoke and in so-called "problem buildings...
  67. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..Because the nose and the maxillary sinuses are separate cavities, we hypothesize that allergic inflammation in the nose triggers ..
  68. AN ECM SCAFFOLD FOR HEAD AND NECK REPAIR
    Alan Spievack; Fiscal Year: 2001
    ..The surgical repair/reconstruction of head and neck structures such as the palate, tongue, nose and orbit, larynx, pharynx, and facial skin structures presently involves the use of complicated autograft ..
  69. THE CLOUD ADULT
    Robert Sherertz; Fiscal Year: 2003
    ..aureus and whether airborne dispersal in this setting is further increased by nose breathing, coughing, or sneezing...
  70. Intra-operative confocal imaging-guided Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2006
    ..because they occur most frequently on older people and in high risk anatomical sites (near or on the eyes, mouth, nose, ears), precise microsurgery is necessary with minimum damage to the surrounding normal tissue...
  71. MECHANISMS OF OLFACTORY TRANSDUCTION
    John Teeter; Fiscal Year: 2003
    ..Odors are detected by millions of sensory neurons in the nose that generate an electrical signal in response to stimulation by particular chemicals...
  72. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2004
    ..competency results in speech characterized by hypernasality, loss of intraoral air pressure through the nose, and articulation disorders...
  73. GENETIC ANALYSIS OF H. INFLUENZAE CAPSULE EXPRESSION
    SUSAN HOISETH; Fiscal Year: 1992
    ..The shift from b+ to b- has been observed in the nose of an infant rat, and b-mutants have been isolated from the nasopharynx of infants with systemic type b disease...