pulmonary alveoli

Summary

Summary: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

Top Publications

  1. pmc Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury
    Mohammad Naimul Islam
    Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Med 18:759-65. 2012
  2. ncbi Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    R D Hautamaki
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Science 277:2002-4. 1997
  3. pmc Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    Brigham C Willis
    Department of Anesthesiology Critical Care Medicine, Childrens Hospital Los Angeles, California, USA
    Am J Pathol 166:1321-32. 2005
  4. pmc TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    Hidenori Kasai
    Teijin Biomedical Laboratory, Medical Research Council Technology, 1 3 Burtonhole Lane, London, NW7 1AD, UK
    Respir Res 6:56. 2005
  5. ncbi Identification of bronchioalveolar stem cells in normal lung and lung cancer
    Carla F Bender Kim
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell 121:823-35. 2005
  6. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
  7. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
  8. pmc Alveolar epithelial type II cell: defender of the alveolus revisited
    H Fehrenbach
    Institute of Pathology, University Clinics Carl Gustav Carus, Technical University of Dresden, Germany
    Respir Res 2:33-46. 2001
  9. ncbi Avian flu: influenza virus receptors in the human airway
    Kyoko Shinya
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 440:435-6. 2006
  10. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005

Detail Information

Publications346 found, 100 shown here

  1. pmc Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury
    Mohammad Naimul Islam
    Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Med 18:759-65. 2012
    ..This is the first evidence, to our knowledge, that BMSCs protect against ALI by restituting alveolar bioenergetics through Cx43-dependent alveolar attachment and mitochondrial transfer...
  2. ncbi Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    R D Hautamaki
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Science 277:2002-4. 1997
    ..Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke...
  3. pmc Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    Brigham C Willis
    Department of Anesthesiology Critical Care Medicine, Childrens Hospital Los Angeles, California, USA
    Am J Pathol 166:1321-32. 2005
    ..These results suggest that AECs undergo EMT when chronically exposed to TGF-beta1, raising the possibility that epithelial cells may serve as a novel source of myofibroblasts in IPF...
  4. pmc TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    Hidenori Kasai
    Teijin Biomedical Laboratory, Medical Research Council Technology, 1 3 Burtonhole Lane, London, NW7 1AD, UK
    Respir Res 6:56. 2005
    ..We examined whether the potent fibrogenic cytokine TGF-beta1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-beta1-mediated EMT...
  5. ncbi Identification of bronchioalveolar stem cells in normal lung and lung cancer
    Carla F Bender Kim
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell 121:823-35. 2005
    ..Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to BASCs as the putative cells of origin for this subtype of lung cancer...
  6. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis...
  7. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    ..Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells...
  8. pmc Alveolar epithelial type II cell: defender of the alveolus revisited
    H Fehrenbach
    Institute of Pathology, University Clinics Carl Gustav Carus, Technical University of Dresden, Germany
    Respir Res 2:33-46. 2001
    ..Although most data support the concept, the controversy about the character of hyperplastic AE2 cells, reported to synthesise profibrotic factors, proscribes drawing a definite conclusion today...
  9. ncbi Avian flu: influenza virus receptors in the human airway
    Kyoko Shinya
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 440:435-6. 2006
    ..Our findings may provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs...
  10. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
    ..Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells...
  11. pmc The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 136:3741-5. 2009
    ..Taken together, this evidence supports a model in which the distal tip of the developing lung contains a multipotent epithelial population, the fate of which changes during development...
  12. ncbi Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization
    Bernard Thebaud
    Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Canada
    Circulation 112:2477-86. 2005
    ..Vascular endothelial growth factor (VEGF) is a trophic factor required for endothelial cell survival and is abundantly expressed in the lung...
  13. pmc Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection
    Pooja A Kumar
    Genome Institute of Singapore, A STAR, Singapore
    Cell 147:525-38. 2011
    ....
  14. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    ..In summary, treatment with allogeneic human MSCs or the conditioned medium restores normal fluid balance in an ex vivo perfused human lung injured by E. coli endotoxin...
  15. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ....
  16. ncbi Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502 CP 14080, Mexico DF, Mexico
    Proc Am Thorac Soc 3:364-72. 2006
    ..In this article, some characteristics of the alveolar epithelium are briefly outlined, and the fibrogenic mechanisms specifically operated by active abnormal epithelial cells are examined...
  17. pmc Early restriction of peripheral and proximal cell lineages during formation of the lung
    Anne Karina T Perl
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 99:10482-7. 2002
    ....
  18. pmc Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization
    Bi Sen Ding
    Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cell 147:539-53. 2011
    ..VEGFR2 and FGFR1 activation in PCECs therefore increases MMP14-dependent bioavailability of EGFR ligands to initiate and sustain alveologenesis...
  19. pmc AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
    István Vadász
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Invest 118:752-62. 2008
    ....
  20. ncbi Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Immunol 177:1817-24. 2006
    ....
  21. pmc Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
    Thomas H Sisson
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, 6301 MSRB III, Ann Arbor, MI 48109 5642, USA
    Am J Respir Crit Care Med 181:254-63. 2010
    ..Although these findings are compelling, there are no studies that demonstrate a direct role for the alveolar epithelium or, more specifically, type II cells in the scarring process...
  22. ncbi Receptor for advanced glycation end-products is a marker of type I lung alveolar cells
    Madoka Shirasawa
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Genes Cells 9:165-74. 2004
    ..In conclusion, RAGE is a marker for basolateral membranes of well-differentiated ATI cells. ATI cells require some signal provided by the in vivo environment to express RAGE...
  23. ncbi Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages
    Andrew J Thorley
    Lung Cell Biology, Section of Airways Disease, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 178:463-73. 2007
    ....
  24. pmc Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
    Martina Korfei
    University of Giessen Lung Center, Department of Internal Medicine II, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Respir Crit Care Med 178:838-46. 2008
    ..The molecular pathomechanisms underlying idiopathic pulmonary fibrosis (IPF) are elusive, but chronic epithelial injury has recently been suggested as key event...
  25. pmc Epithelial origin of myofibroblasts during fibrosis in the lung
    Brigham C Willis
    Division of Pulmonary and Critical Care Medicine, University of Southern California, IRD 620, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Am Thorac Soc 3:377-82. 2006
    ....
  26. pmc Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
    Thomas E Sussan
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:250-5. 2009
    ..These results suggest that targeting the Nrf2 pathway during the etiopathogenesis of emphysema may represent an important approach for prophylaxis against COPD...
  27. ncbi Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    Veerle Compernolle
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity, Institute for Biotechnology, Leuven, Belgium
    Nat Med 8:702-10. 2002
    ..The pneumotrophic effect of VEGF may have therapeutic potential for lung maturation in preterm infants...
  28. ncbi Pathology of new bronchopulmonary dysplasia
    Jacqueline J Coalson
    University of Texas Health Science Center, 7703 Floyd Curl Drive, 78229, San Antonio, TX, USA
    Semin Neonatol 8:73-81. 2003
    ..The alveolar and capillary hypoplasia of new BPD will require the development of specific therapies, but avoiding volutrauma, oxidant injury and inflammation/infection will improve lung morphology...
  29. ncbi Alveolar cell senescence in patients with pulmonary emphysema
    Takao Tsuji
    First Department of Medicine, Tokyo Women s Medical University 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Am J Respir Crit Care Med 174:886-93. 2006
    ..In this study we investigated whether the senescence of alveolar epithelial and endothelial cells is accelerated in emphysematous lungs...
  30. ncbi Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of human alveolar epithelial type I cells
    Nina Demling
    Institute of Immunology, Medical Faculty, Technical University of Dresden, Fetscherstrasse 42, 01307, Dresden, Germany
    Cell Tissue Res 323:475-88. 2006
    ..RAGE might thus assist AT I cells to acquire a spreading morphology, thereby ensuring effective gas exchange and alveolar stability...
  31. pmc Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease
    Jeffrey A Whitsett
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Annu Rev Med 61:105-19. 2010
    ....
  32. ncbi Pulmonary surfactant: functions and molecular composition
    J Goerke
    Cardiovascular Research Institute and Department of Physiology, University of California, 3333 California Street, Suite 150, San Francisco, CA 94118, USA
    Biochim Biophys Acta 1408:79-89. 1998
    ..It is concluded that, in spite of much effort, we still do not understand the basic molecular mechanisms underlying surfactant's rapid adsorption to the air-water interface...
  33. pmc Innate immune responses to bacterial ligands in the peripheral human lung--role of alveolar epithelial TLR expression and signalling
    Andrew J Thorley
    Lung Cell Biology, Section of Pharmacology and Toxicology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 6:e21827. 2011
    ....
  34. pmc Innate immune response to influenza A virus in differentiated human alveolar type II cells
    Jieru Wang
    Department of Medicine, National Jewish Health, 1400 Jackson St, A448, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 45:582-91. 2011
    ..This study provides insights into influenza-induced innate immunity in differentiated human ATII cells, and demonstrates that the alveolar epithelium is a critical part of the initial innate immune response to influenza...
  35. ncbi ARDS and diffuse alveolar damage: a pathologist's perspective
    Claudia Y Castro
    The University of Texas Medical Branch UTMB, Department of Pathology, Galveston, TX 77555, USA
    Semin Thorac Cardiovasc Surg 18:13-9. 2006
    ..The factors that govern which patients will do well and which will develop a fulminant course is not known...
  36. ncbi Alveolar type I cells: molecular phenotype and development
    Mary C Williams
    Pulmonary Center and Department of Anatomy, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Annu Rev Physiol 65:669-95. 2003
    ..Cell systems and reagents are available to characterize type I cell biology in detail, an important goal given that the cells provide the extensive surface that facilitates gas exchange in the intact animal...
  37. pmc The receptor for advanced glycation end products (RAGE) and the lung
    Stephen T Buckley
    School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland
    J Biomed Biotechnol 2010:917108. 2010
    ..Whilst RAGE undoubtedly plays an important role in the biology of the lung, it remains unclear as to the exact nature of this contribution under both physiological and pathological conditions...
  38. pmc Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro
    Jieru Wang
    Department of Medicine, National Jewish and Medical Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 36:661-8. 2007
    ..The expression of the phenotypes is regulated by the culture conditions and is, in part, reversible in vitro...
  39. pmc Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction
    Adam Giangreco
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Pathol 161:173-82. 2002
    ..These studies identify a BADJ-associated, NEB-independent, CCSP-expressing stem cell population in terminal bronchioles and support the notion that regiospecific stem cell niches function to maintain epithelial diversity after injury...
  40. ncbi Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
    R J Kaner
    Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Cell Mol Biol 22:657-64. 2000
    ..Together, these data suggest that overexpression of VEGF in the lung may be one mechanism of increased pulmonary vascular permeability in the early stages of acute lung injury...
  41. ncbi Pathology of bronchopulmonary dysplasia
    Jacqueline J Coalson
    University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Semin Perinatol 30:179-84. 2006
    ..The concept that "new" BPD results in an arrest in alveolization should be modified to that of an impairment in alveolization as evidence shows that short ventilatory times and/or the use of nCPAP allow continued alveolar formation...
  42. ncbi Structural aspects of postnatal lung development - alveolar formation and growth
    Peter H Burri
    Institute of Anatomy, University of Berne, Berne, Switzerland
    Biol Neonate 89:313-22. 2006
    ..Because of the high plasticity of the lung tissues, late alveolarization or some forms of compensatory alveolar formation may be considered for the human lung...
  43. pmc Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice
    Matthias Clauss
    Indiana Center for Vascular Biology and Medicine and Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, Indiana 46202, USA
    J Clin Invest 121:2470-9. 2011
    ..In conclusion, we suggest that EMAPII perpetuates the mechanism of CS-induced lung emphysema in mice and, given its secretory nature, is a suitable target for neutralization antibody therapy...
  44. ncbi Pulmonary pathology of acute respiratory distress syndrome
    J F Tomashefski
    Department of Pathology, MetroHealth Medical Center, Cleveland, Ohio, USA
    Clin Chest Med 21:435-66. 2000
    ....
  45. pmc Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection
    Jieru Wang
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 182:1296-304. 2009
    ..These results suggest that IL-29 exerts IFN-beta-independent protection in type II cells through direct activation of antiviral genes during IAV infection...
  46. ncbi Role of extracellular adenosine in acute lung injury
    Tobias Eckle
    Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado Denver, Aurora, Colorado, USA
    Physiology (Bethesda) 24:298-306. 2009
    ..As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI...
  47. pmc HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice
    Yogesh Saini
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1319, USA
    J Biol Chem 283:33650-7. 2008
    ..These results suggest that HIF1alpha is essential for proper lung maturation and alteration in its normal signaling during premature delivery might explain the pathophysiology of neonatal RDS...
  48. pmc Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs
    Brent Reyburn
    Department of Pediatrics, Division of Neonatology, University of Utah Health Sciences Center, Williams Building, PO Box 581289, Salt Lake City, UT 84158, USA
    Am J Respir Crit Care Med 178:407-18. 2008
    ..In normally developing lungs, by comparison, remodeling of the immature parenchymal architecture is characterized by thinning of the future alveolar walls, a process predicated on cell loss through apoptosis...
  49. ncbi Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase
    Ian R Witherden
    Lung Cell Biology, National Heart and Lung Institute, Imperial College of Science, London, United Kingdom
    Am J Respir Cell Mol Biol 30:500-9. 2004
    ..We hypothesize that reduced ATII cell-derived chemokine levels compromise alveolar repair, contributing to cigarette smoke-induced alveolar damage and emphysema...
  50. ncbi Effects and uptake of gold nanoparticles deposited at the air-liquid interface of a human epithelial airway model
    C Brandenberger
    Institute of Anatomy, Division of Histology, University of Bern, Bern, Switzerland
    Toxicol Appl Pharmacol 242:56-65. 2010
    ..With this experimental setup, reflecting the physiological conditions more precisely, no adverse effects from gold NPs were observed. However, chronic studies under in vivo conditions are needed to entirely exclude adverse effects...
  51. pmc Type I alveolar epithelial phenotype in primary culture
    Shaohua Wang
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Respir Cell Mol Biol 44:692-9. 2011
    ..Although the ability of ATIs to divide may be limited to the in vitro environment, we do believe that their role in alveolar wound repair deserves to be revisited, and the molecular control of ATI-ATII plasticity further explored...
  52. ncbi Up-regulation of receptors for advanced glycation end-products by alveolar epithelium influences cytodifferentiation and causes severe lung hypoplasia
    Paul R Reynolds
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 94602, USA
    Am J Respir Cell Mol Biol 45:1195-202. 2011
    ..Furthermore, abundant RAGE results in profound alterations in epithelial cell differentiation that culminate in severe respiratory distress and perinatal lethality...
  53. pmc Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner
    Amarjit Mishra
    Lundberg Kienlen Lung Biology and Toxicology Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Cell Sci 124:657-68. 2011
    ..These results suggest that the activation of P2X(7)R increases surfactant secretion by releasing ATP from AEC I and subsequently stimulating P2Y(2) receptors in AEC II...
  54. pmc Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport
    Meshell D Johnson
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:4964-9. 2006
    ....
  55. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010
    ..If progressive high altitude acclimatization would not be possible, prophylaxis with nifedipine or tadalafil for long sojourns at high altitude or dexamethasone for a short stay of less then 5 days should be recommended...
  56. ncbi A novel method for isolating individual cellular components from the adult human distal lung
    Naoya Fujino
    Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Am J Respir Cell Mol Biol 46:422-30. 2012
    ....
  57. pmc Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Kurt H Albertine
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
    Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010
    ..We conclude that vitamin A treatment partially improves lung development in chronically ventilated preterm neonates by modulating expression of tropoelastin, deposition of elastin, and expression of vascular growth factors...
  58. ncbi Nonhomogeneous density of CD34 and VCAM-1 alveolar capillaries in major types of idiopathic interstitial pneumonia
    Edwin Roger Parra
    Division of Pathology, Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    Lung 183:363-73. 2005
    ..These results indicate the presence of temporal nonhomogeneic vascular remodeling indiopathic interstitial pneumonia...
  59. pmc Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Mailcode 175217, Los Angeles, CA, USA
    Respir Res 12:134. 2011
    ..The purpose of this study was to test our hypothesis that targeted deletion of NF-κB signaling in lung epithelium would impair alveolar formation...
  60. ncbi Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
    G Dranoff
    Whitehead Institute for Biomedical Research, Cambridge, MA
    Science 264:713-6. 1994
    ..These results demonstrate that GM-CSF is not an essential growth factor for basal hematopoiesis and reveal an unexpected, critical role for GM-CSF in pulmonary homeostasis...
  61. pmc FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa
    Yuru Liu
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Exp Med 208:1473-84. 2011
    ..Thus, expression of FoxM1 in type II cells is essential for their proliferation and transition into type I cells and for restoring alveolar barrier homeostasis after PA-induced lung injury...
  62. ncbi Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema
    Khalil J Diab
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Am J Respir Crit Care Med 181:344-52. 2010
    ..The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism...
  63. pmc Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis
    Veronika Pozharskaya
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7559. 2009
    ..We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist...
  64. ncbi Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system
    Xiaohui Fang
    Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L104-10. 2004
    ..In conclusion, this novel in vitro system can be used to measure net vectorial fluid transport across cultured, polarized alveolar epithelial cells...
  65. pmc Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma
    Thaddeus D Allen
    G W Hooper Research Foundation, University of California, San Francisco, San Francisco, California 94143 0552, USA
    Cancer Res 71:6010-8. 2011
    ..These tumor models should be valuable for exploring the role of activated Notch1 in the genesis of NSCLC and for testing therapies targeting either activated Notch1 or its downstream effectors...
  66. pmc Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 92:7794-8. 1995
    ..Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth...
  67. ncbi Developmental alveolarization of the mouse lung
    Sonja I Mund
    Institute of Anatomy, University of Bern, Switzerland
    Dev Dyn 237:2108-16. 2008
    ..We conclude that alveolarization continues until young adulthood and that the maturation of the alveolar microvasculature does not preclude further alveolarization...
  68. ncbi Fractionated exhaled breath condensate collection shows high hydrogen peroxide release in the airways
    Winfried Möller
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Clinical Cooperation Group Inflammatory Lung Diseases, Institute for Lung Biology and Disease iLBD, Gauting, Germany
    J Aerosol Med Pulm Drug Deliv 23:129-35. 2010
    ..However, there are still unresolved issues reflected by large variations in exhaled H(2)O(2) and uncertainties about the origin of H(2)O(2) release in the lung...
  69. pmc A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:3301-15. 2008
    ..Taken together, these studies reveal a role for A2BAR signaling in attenuating VILI and implicate this receptor as a potential therapeutic target during acute lung injury...
  70. ncbi Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life
    Madhulika Jupelli
    Department of Biology, South Texas Center for Emerging Infectious Disease, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Lab Invest 91:1530-9. 2011
    ..The results of our studies also emphasize the importance of prenatal screening and treatment of pregnant women for C. trachomatis in order to prevent the infection of neonates...
  71. ncbi N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)
    Manuel Mata
    Research Foundation of the University General Hospital of Valencia, Avenida Tres Cruces No 2, Valencia, Spain
    Biochem Pharmacol 82:548-55. 2011
    ..NAC also inhibited replication of the three viruses under study. This work supports the use of antioxidants in order to ameliorate the inflammatory effects of different viral infections during COPD exacerbations...
  72. ncbi Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis
    Philip J Klemmer
    Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill 27599 7155, USA
    Am J Kidney Dis 42:1149-53. 2003
    ..Unlike Goodpasture's syndrome with diffuse alveolar hemorrhage (DAH), there are few studies examining therapy for patients with DAH associated with antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitis (SVV)...
  73. ncbi Regulation of surfactant secretion in alveolar type II cells
    Alexandra V Andreeva
    Department of Pharmacology, University of Illinois College of Medicine, Center for Lung and Vascular Biology, Chicago, IL, USA
    Am J Physiol Lung Cell Mol Physiol 293:L259-71. 2007
    ..Lamellar bodies-independent secretion is also considered. Signal transduction pathways involved in regulation of these processes are discussed as well as disorders associated with their malfunction...
  74. pmc SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells
    Eric C Mossel
    Colorado State University, Fort Collins, CO 80523, USA
    Virology 372:127-35. 2008
    ..Hence, differentiated adult human alveolar type II cells were infectible but alveolar type I-like cells and alveolar macrophages did not support productive infection...
  75. ncbi Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
    Annika Andersson-Sjöland
    Department of Clinical Medical Science, Division of Respiratory Medicine and Allergology, Lund University, Sweden
    Int J Biochem Cell Biol 40:2129-40. 2008
    ..41; p<0.04). These findings indicate that circulating fibrocytes, likely recruited through the CXCR4/CXCL12 axis, may contribute to the expansion of the fibroblast/myofibroblast population in idiopathic pulmonary fibrosis...
  76. ncbi Gas diffusion and alveolar-capillary unit in chronic heart failure
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Eur Heart J 27:2538-43. 2006
    ..Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown...
  77. ncbi Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats
    D M Guidot
    Atlanta Veterans Affairs Medical Center, Decatur 30033, USA
    Am J Physiol Lung Cell Mol Physiol 279:L127-35. 2000
    ....
  78. pmc Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia
    Meera Subramaniam
    Department of Medicine, Pulmonary Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 176:902-12. 2007
    ..quot;..
  79. ncbi Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative
    Wen Jing Wang
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Sci 116:683-92. 2003
    ..The heterotypic oligomerization of hSP-C(1-197) and hSP-C(deltaExon4) provides a molecular mechanism for the dominant-negative effect observed in vivo...
  80. ncbi Biology of alveolar type II cells
    Robert J Mason
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado, Denver, CO 80206, USA
    Respirology 11:S12-5. 2006
    ..However, the type II cells work in concert with the other cells in the gas exchange regions of the lung to keep the alveoli open and reduce inflammation due to irritants in the air we breathe...
  81. pmc Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone
    Chiranjib Dasgupta
    Departments of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1031-41. 2009
    ..Administration of PPARgamma agonists may thus be a potential strategy to attenuate hyperoxia-induced lung injury and subsequent BPD...
  82. ncbi Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development
    Min Yee
    Department of Pediatrics, Box 850, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1101-11. 2006
    ..These data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells...
  83. pmc Short telomeres are a risk factor for idiopathic pulmonary fibrosis
    Jonathan K Alder
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 105:13051-6. 2008
    ..The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver...
  84. pmc Alveolar macrophages transport pathogens to lung draining lymph nodes
    Alun C Kirby
    Department of Biology, Centre for Immunology and Infection, Hull York Medical School, University of York, York, United Kingdom
    J Immunol 183:1983-9. 2009
    ....
  85. ncbi Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
    Timothy J M Moss
    School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 165:805-11. 2002
    ....
  86. ncbi Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Cell Physiol 292:C1280-90. 2007
    ....
  87. ncbi Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury
    Haiying Zhang
    Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Respir Crit Care Med 178:356-62. 2008
    ..The interaction of receptor for advanced glycation end products (RAGE) and its ligands often leads to inflammatory processes or tissue injury, although the effect of the blockade of RAGE signaling on lung injury remains to be investigated...
  88. ncbi MicroRNA expression profile of bronchioalveolar stem cells from mouse lung
    Shen Qian
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Xinquiao Street No 2, Shapingba Di, Chongqing 400037, PR China
    Biochem Biophys Res Commun 377:668-73. 2008
    ....
  89. ncbi Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats
    D M Guidot
    Atlanta Veterans Affairs Medical Center and Division of Pulmonary and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 24:1070-6. 2000
    ..Therefore, we hypothesized that alveolar epithelial mitochondrial glutathione depletion mediates the observed defects in surfactant synthesis and secretion in ethanol-fed rats...
  90. ncbi CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury
    Jeff N Vanderbilt
    Cardiovascular Research Institute Pediatrics, University of California San Francisco, Laurel Heights Campus, Suite 150, 3333 California Street, San Francisco, CA 94118, USA
    Am J Respir Cell Mol Biol 29:661-8. 2003
    ....
  91. ncbi Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings
    Andres Esteban
    Hospital Universitario de Getafe, Madrid, Spain
    Ann Intern Med 141:440-5. 2004
    ..The American-European Consensus Conference definition for the acute respiratory distress syndrome (ARDS) has never been validated...
  92. ncbi Diffuse alveolar hemorrhage
    Harold R Collard
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, C272, Denver, CO 80262, USA
    Clin Chest Med 25:583-92, vii. 2004
    ..In patients with evidence of diffuse alveolar hemorrhage and renal involvement, kidney biopsy should be considered to identify the underlying cause and help direct therapy...
  93. pmc Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epithelia
    Brian C DiPaolo
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania19104 6321, USA
    Am J Physiol Cell Physiol 299:C345-53. 2010
    ..In summary, stretch of primary rat AEC monolayers forms PJARs and rapidly reorganized actin binding sites at the plasma membrane in a manner dependent on stretch magnitude and frequency...
  94. ncbi Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells
    Hajer Debbabi
    Division of Rheumatology, Brigham and Women s Hospital, Smith Bldg, RM 516, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 289:L274-9. 2005
    ..This represents a novel role for type II AEC in the immunological response to pulmonary pathogens...
  95. ncbi ABCA3 gene mutations in newborns with fatal surfactant deficiency
    Sergey Shulenin
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD, USA
    N Engl J Med 350:1296-303. 2004
    ..The gene for ATP-binding cassette transporter A3 (ABCA3) is expressed in alveolar type II cells, and the protein is localized to lamellar bodies, suggesting that it has an important role in surfactant metabolism...
  96. ncbi ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure
    Salvatore Grasso
    Universita di Bari, Dipartimento dell Emergenza e Trapianti d Organo DETO, Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
    Am J Respir Crit Care Med 176:761-7. 2007
    ....
  97. ncbi Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ....
  98. ncbi The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
    J Pugin
    Department of Internal Medicine, University Hospital of Geneva, Switzerland
    Crit Care Med 27:304-12. 1999
    ....
  99. ncbi Interstitial lung disease induced by drugs and radiation
    Philippe Camus
    Department of Pulmonary and Intensive Care, University Medical Center Le Bocage and Medical School, Universite de Bourgogne, Dijon, France
    Respiration 71:301-26. 2004
    ..Rechallenge is justified in a minority of patients, and is discouraged for diagnostic purposes only. Pneumotox (www.pneumotox.com) provides updated information on drug-induced respiratory disease...
  100. ncbi FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, 10 Center Drive, National Institutes of Health, Bethesda, MD, USA
    Development 125:3615-23. 1998
    ..These data revealed a cooperative function of FGFR-3 and FGFR-4 to promote the formation of alveoli during postnatal lung development...
  101. ncbi Loss of PECAM-1 function impairs alveolarization
    Horace M DeLisser
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Biol Chem 281:8724-31. 2006
    ..These data suggest that the loss of PECAM-1 function compromises postnatal lung development and provide evidence that inhibition of EC function, in contrast to a loss of viable EC, inhibits alveolarization...

Research Grants65

  1. REMEDIATION OF EMPHYSEMA--MECHANISMS, CHARACTERISTICS
    Donald Massaro; Fiscal Year: 2001
    DESCRIPTION: This applicant has had a long-standing interest in the biology of the formation of pulmonary alveoli during post-natal development...
  2. Molecular and Cellular Analyses of Aquaporins in Lung
    LANDON KING; Fiscal Year: 2005
    ..These studies should provide insight into mechanisms regulating expression of AQP1 and AQP5, and establish a framework from which to better understand their role in the pathophysiology of the respiratory tract. ..
  3. Interaction of H. capsulatum with Dendritic Cells
    Simon Newman; Fiscal Year: 2006
    ..Infection with Hc is acquired by inhalation of microconidia into the pulmonary alveoli. The conidia convert into the pathogenic yeast phase, and yeasts are phagocytized by alveolar macrophages (..
  4. BIOPHYSICS OF SURFACTANT DURING LUNG DEVELOPMENT
    ALAN MAUTONE; Fiscal Year: 1993
    The surface of pulmonary alveoli is lined by an acellular material, the components of which have been termed the pulmonary surfactant system...
  5. INTERACTION OF H CAPSULATUM WITH MACROPHAGES AND PMN
    Simon Newman; Fiscal Year: 2000
    ..Infection with Hc is acquired by inhalation of microconidia or small mycelial fragments into pulmonary alveoli. Inhaled conidia convert into the pathogenic yeast phase within an unknown time frame...
  6. METABOLISM OF NEUTRAL LIPIDS IN THE PULMONARY ALVEOLUS
    Fred Smith; Fiscal Year: 1980
    ....
  7. Alveolar Biology: Sex, Age, and Alveolar Turnover
    Donald Massaro; Fiscal Year: 2007
    ..abstract_text> ..
  8. EXPERIMENTAL EMPHYSEMA--STUDIES ON REMEDIATION
    Donald Massaro; Fiscal Year: 2001
    ....
  9. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  10. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  11. SITES AND MECHANISMS OF INHALED ANESTHETIC ACTIONS
    EDMOND EGER; Fiscal Year: 2008
    ..abstract_text> ..
  12. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  13. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  14. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2008
    ....
  15. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  16. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  17. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  18. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  19. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
  20. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
    ..abstract_text> ..
  21. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2007
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  22. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2007
    ..At the same time the findings of this project may lay down the foundation for realistic and rationally based inhalation dosimetry in children - a matter of great clinical importance. [unreadable] [unreadable]..
  23. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2009
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  24. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..
  25. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..
  26. VEGF and Nitric Oxide in Lung Vascular Development
    Vivek Balasubramaniam; Fiscal Year: 2007
    ..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
  27. Discovery of biomarkers of pulmonary hypertension
    Rubin Tuder; Fiscal Year: 2005
    ..abstract_text> ..
  28. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2008
    ..abstract_text> ..
  29. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  30. Immunomodulatory Effects of Mechanical Ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2007
    ....
  31. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009
    ..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..
  32. ANP Modulates Cardiac Remodeling via Cardiac Fibroblasts
    Yiu Fai Chen; Fiscal Year: 2009
    ..These mechanistic studies will provide a more rational basis for therapeutic intervention in patients with cardiac dysfunction/failure, many of whom have decreased levels of ANP. ..
  33. Diabetic Microangiopathy and Alveolar O2 Transport
    Connie C W Hsia; Fiscal Year: 2010
    ..Given the current intense interest in the development of inhaled insulin therapy, there is a growing need to understand the effects of diabetic progression and treatment on lung function. ..
  34. SCCOR in Translational Research in Acute Lung Injury
    Thomas Martin; Fiscal Year: 2007
    ..The proposed SCCOR Program will enhance understanding of the pathogenesis of lung injury and could lead to new treatments and improved long-term outcome for patients with acute lung injury. ..
  35. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  37. ATRIAL NATRIURETIC PEPTIDE AND RECEPTOR GENES IN HYPOXIA
    Yiu Fai Chen; Fiscal Year: 2010
    ..Our proposed mechanistic studies will lead to innovative and effective therapeutic approaches to this important cause of morbidity and mortality in the American population. ..
  38. Mechanisms Of Compensatory Lung Growth
    Connie C W Hsia; Fiscal Year: 2010
    ..abstract_text> ..
  39. ALVEOLO-CAPILLARY SIGNALING IN LUNG IMMUNOLOGY
    Jahar Bhattacharya; Fiscal Year: 2009
    ..This research is novel and it will advance our understanding of fundamental mechanisms regulating lung inflammation. ..
  40. HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGY
    John Torday; Fiscal Year: 2009
    ..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..
  41. Center for Development of Biological Nanosensors (RMI)
    Douglas Eaton; Fiscal Year: 2004
    ..This knowledge may lead to better understanding and new strategies for treatment of disorders specifically related to cell communication crocesses like diabetes, cystic fibrosis in the lung, and polycystic kidney disease...
  42. COLLABORATIVE PROGRAM IN BPD
    Jacqueline Coalson; Fiscal Year: 2007
    ..It allows, at a national level, a continuing influx of outstanding scientists to address the major deficiencies in our knowledge concerning BPD. ..
  43. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
    ..The opportunities provided by the training program will provide the foundation for career advancement and hopefully lead to new therapies for fibrotic lung diseases. ..
  44. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  45. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
    ..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..
  46. INTERACTION OF CFTR AND EPITHELIAL NA CHANNELS
    Douglas Eaton; Fiscal Year: 2003
    ..These studies will provide new information about mechanisms of coordinate regulation of epithelial Na and C1 transport. ..
  47. MOLECULAR MECHANISMS OF LUNG INFLAMMATION
    Thomas Martin; Fiscal Year: 2002
    ....
  48. Proinflammatory Signaling in the Pulmonary Circulation
    Jahar Bhattacharya; Fiscal Year: 2002
    ..Both the site and the format of the conference have proved successful in earlier meetings. ..
  49. ENDOTHELIN AND RECEPTOR GENE EXPRESSION IN HYPOXIA
    Yiu Fai Chen; Fiscal Year: 2001
    ..Cultured endothelial and smooth muscle cells derived from human and rat pulmonary microvessels and systemic vascular beds will be studied in Specific Aims 3 and 4. ..
  50. REGULATION OF SODIUM TRANSPORT IN TIGHT EPITHELIA
    Douglas Eaton; Fiscal Year: 2001
    ..questions will be answered is there any difference in the action of insulin and IGF-1 on A6 cells? Which Na channel subunits are tyrosine phosphorylated by IGF-1? Are there effects of tyrosine kinases in the absence of insulin or IGF-1? ..
  51. Endogenous programmed alveolar turnover in adult lung
    GLORIA MASSARO; Fiscal Year: 2005
    ....
  52. Genetic Control of SP-B Gene Expression in the Lung
    Cong Yan; Fiscal Year: 2006
    ..abstract_text> ..
  53. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  54. Retinoic Acid and Post-pneumonectomy Lung Growth
    CONNIE HSIA; Fiscal Year: 2006
    ..e., the consequences when a natural compensatory response is distorted by pharmacological manipulation that selectively alters some but not all aspects of the natural response. ..
  55. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  56. Nuclear Receptor Co-Activators in the Lung
    Cong Yan; Fiscal Year: 2006
    ..abstract_text> ..
  57. ENaC ASSEMBLY, TRAFFICKING AND DEGRADATION IN LUNG
    Douglas Eaton; Fiscal Year: 2006
    ..abstract_text> ..
  58. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2007
    ..The FAKP studies are outstandingly novel. They will directly test the critical role of FAK in causing barrier enhancement, and reveal FAK therapy as a novel therapeutic possibility for ALI. ..
  59. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2005
    ....
  60. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  61. THE NHLBI-BAY AREA FUNCTIONAL GENOMICS CONSORTIUM
    Dean Sheppard; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Component 4-6). ..
  62. TRANSMISSION OF PNEUMOCYSTIS INFECTION
    Melanie Cushion; Fiscal Year: 2001
    ..These studies will result in a clearer understanding of the biology leading to infection with Pc and will provide a rational basis for clinical management and therapeutic intervention. ..
  63. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2005
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..