bronchi

Summary

Summary: The larger air passages of the lungs arising from the terminal bifurcation of the trachea.

Top Publications

  1. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  2. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
  3. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
  4. pmc Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    Peter A B Wark
    The Brooke Laboratories, University of Southampton, Southampton SO16 6YD, UK
    J Exp Med 201:937-47. 2005
  5. pmc Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium
    Louise Slater
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS Pathog 6:e1001178. 2010
  6. pmc Motile cilia of human airway epithelia are chemosensory
    Alok S Shah
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 325:1131-4. 2009
  7. ncbi Avian flu: influenza virus receptors in the human airway
    Kyoko Shinya
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 440:435-6. 2006
  8. pmc Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    Deepak A Deshpande
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1299-304. 2010
  9. ncbi Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
    John V Fahy
    University of California at San Francisco, Box 0130, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Proc Am Thorac Soc 6:256-9. 2009
  10. ncbi Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    James C Hogg
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Lancet 364:709-21. 2004

Detail Information

Publications316 found, 100 shown here

  1. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  2. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
    ..IL-13 may play an important role in the pathogenesis of similar responses in asthma or other Th2-polarized tissue responses...
  3. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    ..We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle...
  4. pmc Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    Peter A B Wark
    The Brooke Laboratories, University of Southampton, Southampton SO16 6YD, UK
    J Exp Med 201:937-47. 2005
    ..These data suggest a novel use for type I interferons in the treatment or prevention of virus-induced asthma exacerbations...
  5. pmc Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium
    Louise Slater
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS Pathog 6:e1001178. 2010
    ..Hence anti-viral defense within bronchial epithelium requires co-ordinated recognition of rhinovirus infection, initially via TLR3/TRIF and later via inducible RNA helicases...
  6. pmc Motile cilia of human airway epithelia are chemosensory
    Alok S Shah
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 325:1131-4. 2009
    ..Hence, like primary cilia, classical motile cilia also contain sensors to detect the external environment...
  7. ncbi Avian flu: influenza virus receptors in the human airway
    Kyoko Shinya
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 440:435-6. 2006
    ..Our findings may provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs...
  8. pmc Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    Deepak A Deshpande
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1299-304. 2010
    ..Given the need for efficacious bronchodilators for treating obstructive lung diseases, this pathway can be exploited for therapy with the thousands of known synthetic and naturally occurring bitter tastants...
  9. ncbi Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
    John V Fahy
    University of California at San Francisco, Box 0130, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Proc Am Thorac Soc 6:256-9. 2009
    ..The promise now is that these markers will ultimately guide personalized treatment programs...
  10. ncbi Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    James C Hogg
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Lancet 364:709-21. 2004
    ....
  11. pmc Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
    M C W Chan
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China
    Respir Res 6:135. 2005
    ..Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells...
  12. ncbi Defective epithelial barrier function in asthma
    Chang Xiao
    Synairgen Research Ltd, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 128:549-56.e1-12. 2011
    ..The bronchial epithelium forms the interface with the external environment and is pivotally involved in controlling tissue homeostasis through provision of a physical barrier controlled by tight junction (TJ) complexes...
  13. ncbi Relationship of epidermal growth factor receptors to goblet cell production in human bronchi
    K Takeyama
    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California 94143-0130, USA
    Am J Respir Crit Care Med 163:511-6. 2001
    ..expression at both gene and protein levels using in situ hybridization and immunohistochemical analysis in human bronchi. Bronchial mucosal biopsy specimens were obtained from 12 asthmatic subjects and 11 healthy subjects...
  14. pmc T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients
    A Di Stefano
    Division of Pulmonary Disease, Salvatore Maugeri Foundation, IRCCS, Veruno NO, Italy
    Clin Exp Immunol 157:316-24. 2009
    ..Increased expression of the Th17-related cytokines IL-17A, IL-22 and IL-23 in COPD patients may reflect their involvement, and that of specific IL-17-producing cells, in driving the chronic inflammation seen in COPD...
  15. pmc Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease
    Dina Schneider
    University of Michigan, Ann Arbor, MI 48109 5688, USA
    Am J Respir Crit Care Med 182:332-40. 2010
    ..Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection...
  16. ncbi Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
    Matthias Schmidt
    Avail Biomedical Research Institute and Avail GmbH, Basel, Switzerland
    J Immunol 171:380-9. 2003
    ..These results indicate that circulating fibrocytes may function as myofibroblast precursors and may contribute to the genesis of subepithelial fibrosis in asthma...
  17. pmc Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component
    Wan Yun Cheng
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 120:267-74. 2012
    ..Toxicological studies have correlated inflammatory effects of diesel exhaust particles (DEP) with its organic constituents, such as the organic electrophile 1,2-naphthoquinone (1,2-NQ)...
  18. ncbi Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease
    Sukhwinder S Sohal
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Respirology 15:930-8. 2010
    ..The aim of this study was to confirm the extent and relevance of Rbm fragmentation in smokers and patients with COPD, and to undertake a preliminary analysis of some classical markers of EMT...
  19. ncbi Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    H Matsui
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599 7248, USA
    Cell 95:1005-15. 1998
    ..These data indicate that therapy for CF lung disease should not be directed at modulation of ionic composition, but rather at restoring volume (salt and water) on airway surfaces...
  20. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..Our study showed a close link between smoking and expression of TGF-beta1 in small airways. Our results also suggested that small airway epithelial cells might be involved in obstructive changes found in smokers and patients with COPD...
  21. ncbi Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002
    ..Also, we will examine some novel ionic mechanisms in the context of Ca(2+) handling and excitation-contraction coupling in ASM...
  22. ncbi An optimal bronchial tree may be dangerous
    B Mauroy
    Centre de Mathématiques et de Leurs Applications, Ecole Normale Superieure de Cachan, 94235 Cachan, France
    Nature 427:633-6. 2004
    ..Paradoxically, our results suggest that bronchial malfunction related to asthma is a necessary consequence of the optimized efficiency of the tree structure...
  23. pmc Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
    Kip A West
    Cancer Therapeutics Branch, Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20889, USA
    J Clin Invest 111:81-90. 2003
    ..Redundant Akt activation by nicotine and NNK could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis...
  24. pmc Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary Critical Care and Sleep Medicine, and Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, NY, USA
    Am J Respir Crit Care Med 173:991-8. 2006
    ..This "colonization" of the tracheobronchial tree, currently believed to be innocuous, could serve as an inflammatory stimulus, independent of current tobacco smoke exposure...
  25. ncbi Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease
    Antoni Rosell
    Servei de Pneumologia, Hospital Germans Trias i Pujol, 08916 Badalona, Spain
    Arch Intern Med 165:891-7. 2005
    ....
  26. pmc Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease
    Vasiliy V Polosukhin
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 184:317-27. 2011
    ..Although airway inflammation can persist for years after smoking cessation in patients with chronic obstructive pulmonary disease (COPD), the mechanisms of persistent inflammation are largely unknown...
  27. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
    ..However, clinical studies increasingly suggest that asthma is heterogeneous...
  28. pmc Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells
    Elisabetta Pace
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy
    Immunology 124:401-11. 2008
    ..In conclusion, cigarette smoke, by altering the expression and the activation of TLR4 via the preferential release of IL-8, may contribute to the accumulation of neutrophils within the airways of smokers...
  29. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
    ..01). Our results suggest that the higher amount of tenascin reflects disease activity in asthma and may be an indicator of a remodeling process rather than of injury itself...
  30. pmc Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b
    Zhishan Wang
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 121:110-22. 2011
    ..These findings establish for the first time a causal role for depletion of miR-200b expression in human cell malignant transformation and tumor formation resulting from arsenic exposure...
  31. ncbi Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke
    Audrey Richter
    Respiratory Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, United Kingdom
    Am J Respir Cell Mol Biol 27:85-90. 2002
    ..Our data indicate that secretion of IL-8 in response to CSE is dependent on EGFR activation and that autocrine production of TGF-alpha makes a substantial contribution to this response...
  32. ncbi Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle
    Maria B Sukkar
    Experimental Studies Group, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 118:641-8. 2006
    ..Airway smooth muscle cells (ASMCs) display proinflammatory and immunomodulatory functions. ASMCs might participate in airway inflammatory responses associated with innate immune activation...
  33. ncbi The prediction of small airway dimensions using computed tomography
    Yasutaka Nakano
    Department of Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Respir Crit Care Med 171:142-6. 2005
    ..01). We conclude that CT measurements of airways with a Pi of 0.75 cm or more could be used to estimate the dimensions of the small conducting airways, which are the site of airway obstruction in chronic obstructive pulmonary disease...
  34. ncbi Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion
    K U Hong
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Am J Respir Cell Mol Biol 24:671-81. 2001
    ..These results support the notion that vCE cells represent either an airway stem cell or are critical for stem cell maintenance, and suggest that PNECs are not sufficient for epithelial renewal...
  35. ncbi Lung pathology of fatal severe acute respiratory syndrome
    John M Nicholls
    Department of Pathology, University of Hong Kong, Hong Kong Special Administrative Region, China
    Lancet 361:1773-8. 2003
    ..Severe acute respiratory syndrome (SARS) is a novel infectious disease with global impact. A virus from the family Coronaviridae has been identified as the cause, but the pathogenesis is still unclear...
  36. ncbi Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  37. pmc Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    Mikhail N Matrosovich
    Institute of Virology, Philipps University, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 101:4620-4. 2004
    ..Our data throw light on the mechanisms of generation of pandemic viruses from their avian progenitors and open avenues for cell level-oriented studies on the replication and pathogenicity of influenza virus in humans...
  38. ncbi H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
  39. pmc Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections
    Robert Tarran
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 280:35751-9. 2005
    ....
  40. ncbi Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment
    A Zanini
    Salvatore Maugeri Foundation, Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Italy
    Thorax 64:1019-24. 2009
    ..A study was undertaken to evaluate vascular remodelling, its relationship with inflammatory cells and treatment effects in the bronchial mucosa of patients with COPD...
  41. ncbi Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
    M J Goldman
    Department of Medicine, The University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Cell 88:553-60. 1997
    ..These data suggest that hBD-1 plays an important role in innate immunity that is compromised in CF by its salt-dependent inactivation...
  42. ncbi A role for sensory nerves in the late asthmatic response
    Kristof Raemdonck
    Respiratory Pharmacology Group, Pharmacology and Toxicology, National Heart and Lung Institute, Faculty of Medicine, London, UK
    Thorax 67:19-25. 2012
    ..Although many subjects with asthma consider LAR to be one of the defining symptoms of their disease, and despite its widespread use in the clinical assessment of new therapeutic entities, the mechanism underlying the LAR remains unclear...
  43. ncbi A two-stage logistic model based on the measurement of pro-inflammatory cytokines in bronchial secretions for assessing bacterial, viral, and non-infectious origin of COPD exacerbations
    Roberto W Dal Negro
    Lung Department, Orlandi General Hospital, Bussolengo, Verona, Italy
    COPD 2:7-16. 2005
    ....
  44. ncbi TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA
    Kyoko Niimi
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    J Immunol 178:489-95. 2007
    ....
  45. ncbi 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes
    Yohan Bosse
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Physiol Genomics 29:161-8. 2007
    ..The most significant network of upregulated genes included genes involved in morphogenesis, cell growth, and survival as well as genes encoding structural proteins, which are potentially involved in airway remodeling...
  46. pmc Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine
    Manuel Mata
    Research Foundation of the University General Hospital of Valencia, Valencia, Spain
    PLoS ONE 7:e48037. 2012
    ..The results presented in this study support the therapeutic use of NAC for the management of chronic respiratory diseases, including COPD...
  47. ncbi DNA damage induced by micro- and nanoparticles--interaction with FPG influences the detection of DNA oxidation in the comet assay
    J Kain
    Unit for Analytical Toxicology, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    Mutagenesis 27:491-500. 2012
    ..We conclude that measurement of oxidatively damaged DNA in cells exposed to nanoparticles may be underestimated in the comet assay due to interactions with FPG...
  48. pmc The expression and relaxant effect of bitter taste receptors in human bronchi
    Stanislas Grassin-Delyle
    Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hopital Foch, 11 rue Guillaume Lenoir, F 92150 Suresnes, Paris, France
    Respir Res 14:134. 2013
    ..We sought to identify and characterize the TAS2Rs expressed in isolated human bronchi and the subtypes involved in relaxation.
  49. ncbi Optical differentiation between malignant and benign lymphadenopathy by grey scale texture analysis of endobronchial ultrasound convex probe images
    Phan Nguyen
    The University of Queensland, UQ Centre for Clinical Research, Herston, Australia
    Chest 141:709-15. 2012
    ..The aim of this study was to determine if this methodology could differentiate between benign and malignant lymphadenopathy of EBUS images...
  50. pmc Identification of candidate biomarkers for early detection of human lung squamous cell cancer by quantitative proteomics
    Gu Qing Zeng
    Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China
    Mol Cell Proteomics 11:M111.013946. 2012
    ..The present data first time show that GSTP1, HSPB1 and CKB are novel potential biomarkers for early detection of LSCC, and GSTP1 down-regulation is involved in human bronchial epithelial carcinogenesis...
  51. pmc Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Br J Pharmacol 166:2243-62. 2012
    ....
  52. ncbi E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids
    D Ierodiakonou
    Dept of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Respir J 38:1044-52. 2011
    ..These effects are modified by the use of inhaled corticosteroids...
  53. pmc Foreign body aspiration in children: diagnostic and therapeutic role of bronchoscopy
    Wojciech Korlacki
    Department of Pediatric Surgery in Zabrze, Medical University of Silesia, Katowice, ul 3 Maja 13 15, 41 800, Zabrze, Poland
    Pediatr Surg Int 27:833-7. 2011
    ..Assessment of bronchoscopy usefulness for diagnosis and treatment in children suspected of foreign body aspiration...
  54. pmc The role of the epithelium in airway remodeling in asthma
    Donna E Davies
    The Brooke Laboratories, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Proc Am Thorac Soc 6:678-82. 2009
    ....
  55. ncbi Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
    James L Lordan
    School of Medicine, Respiratory Cell and Molecular Biology Division, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 169:407-14. 2002
    ....
  56. pmc Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers
    Pierre Lesimple
    Department of Physiology, McGill University, Montreal, QC, Canada
    J Physiol 588:1195-209. 2010
    ..A reduction in barrier function caused by endoplasmic reticulum retention of Delta F508-CFTR may contribute to fluid hyperabsorption in CF airways...
  57. ncbi Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide
    Celine Bergeron
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 116:983-9. 2005
    ..It is not clear whether inflammation of the peripheral airways is associated with structural changes and whether this remodeling process can be modulated by deposition of inhaled corticosteroids (ICSs)...
  58. pmc Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection
    N L Korpi-Steiner
    Department of Biomolecular Chemistry, Division of Allergy and Immunology, University of Wisconsin Madison, Madison, WI 53706 0450, USA
    Clin Exp Allergy 40:1203-13. 2010
    ..As HRV-induced cytokine levels in vivo are markedly elevated, this observation suggests that other mechanisms independent of direct viral infection may induce epithelial cell cytokine release...
  59. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
    ....
  60. ncbi Simultaneous stimulation with TGF-β1 and TNF-α induces epithelial mesenchymal transition in bronchial epithelial cells
    Sumiko Kamitani
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 155:119-28. 2011
    ..TGF-β1, which is a potent inducer of EMT, is thought to be related to the pathogenesis of airway remodeling. We investigated whether TGF-β1 and/or TNF-α induce EMT in bronchial epithelial cells...
  61. ncbi Tracheobronchial foreign body aspiration in children: how reliable are clinical and radiological signs in the diagnosis?
    F T Orji
    Department of Otolaryngology, University of Nigeria Teaching Hospital Enugu, Enugu, Nigeria
    Clin Otolaryngol 35:479-85. 2010
    ..To evaluate the yield of clinical and radiological features in the diagnosis of suspected foreign body aspiration in children and to assess factors associated with delayed diagnosis of foreign body aspiration...
  62. ncbi Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation
    W I de Boer
    Department of Pulmonary Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Can J Physiol Pharmacol 86:105-12. 2008
    ..Our results suggest that the lower epithelial alpha-catenin, E-cadherin and (or) ZO-1 expression in patients with atopic asthma contributes to a defective airway epithelial barrier and a higher influx of eosinophils in the epithelium...
  63. pmc Avian influenza viruses infect primary human bronchial epithelial cells unconstrained by sialic acid α2,3 residues
    Christine M Oshansky
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 6:e21183. 2011
    ....
  64. pmc Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
    M Mata
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Thorax 60:144-52. 2005
    ..Recent clinical trials indicate that phosphodiesterase type 4 (PDE4) inhibitors may have therapeutic value for COPD and asthma. However, their direct effects on mucin expression have been scarcely investigated...
  65. ncbi Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 174:1110-8. 2006
    ..Convincing evidence of epithelial damage and aberrant repair exists in adult asthmatic airways, even in the absence of inflammation. However, comparable studies in children have been limited by access and availability of clinical samples...
  66. ncbi Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells
    Anja K Mayer
    Department of Medical Microbiology and Hygiene, University Heidelberg, Im Neuenheimer Feld 324, Heidelberg, Germany
    J Immunol 178:3134-42. 2007
    ..The findings indicate that bronchial epithelium regulates its sensitivity to recognize microbes by managing receptor expression levels. This could serve the special needs of controlled microbial recognition in mucosal compartments...
  67. ncbi Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease
    Willem I de Boer
    Departmen of Pulmonology, Leiden University Medical Center, The Netherlands
    Am J Clin Pathol 125:184-92. 2006
    ..4-1.8 times; P<or=.05) of ex-smokers with COPD compared with ex-smokers without COPD. These data support our hypothesis and suggest that current smoking obscures intrinsically higher expression in COPD...
  68. ncbi Optimal branching asymmetry of hydrodynamic pulsatile trees
    Magali Florens
    CMLA, ENS Cachan, CNRS, UniverSud, 61 Avenue du President Wilson, F 94230 CACHAN, France
    Phys Rev Lett 106:178104. 2011
    ..This could indicate that the structure is tuned at the maximum asymmetry level that allows the lung to feed all terminal units with fresh air...
  69. ncbi Anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles in fetuses measured ex vivo
    - Harjeet
    Department of Anatomy Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Paediatr Anaesth 18:1029-34. 2008
    ..This study is aimed to determine the anatomical dimensions of trachea, main bronchi, subcarinal and bronchial angles and their correlation to age and crown rump length (CRL) in fetuses.
  70. ncbi Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells
    LEAH A DAMIANI
    Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Cancer Res 68:9005-14. 2008
    ..This finding supports the development of demethylation strategies for primary prevention of lung cancer in smokers...
  71. ncbi Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 120:813-9. 2007
    ..Increased vascularity and expression of vascular endothelial growth factor (VEGF) are recognized features of the asthmatic airway. The association of vascular remodeling with airway hyperresponsiveness (AHR) is unclear...
  72. pmc Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
    Xiaoling Zhang
    Bioinformatics Program, Boston University, Boston, Massachusetts 02118, USA
    Physiol Genomics 41:1-8. 2010
    ..Our findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies...
  73. pmc Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 11:60. 2010
    ..The aim of our study was to assess the associations of MRP1 SNPs with FEV1 level, MRP1 protein levels and inflammatory markers in bronchial biopsies and sputum of COPD patients...
  74. ncbi The bronchial circulation--worth a closer look: a review of the relationship between the bronchial vasculature and airway inflammation
    Angela McCullagh
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 45:1-13. 2010
    ..In conjunction with molecular research, measurement of airway blood flow (Q(aw)) may help elucidate the role of the bronchial circulation in inflammatory airway disease and become a useful tool for monitoring therapy...
  75. pmc Human influenza is more effective than avian influenza at antiviral suppression in airway cells
    Alan Chen Yu Hsu
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia
    Am J Respir Cell Mol Biol 44:906-13. 2011
    ..This suggests that the subversion of human antiviral responses may be an important requirement for influenza viruses to adapt to the human host and cause disease...
  76. pmc Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells
    Yi Jing
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Toxicol Sci 125:10-9. 2012
    ....
  77. ncbi Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium
    Xiao Yang Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 87:527-39. 2007
    ..The collective results suggest a novel model of BOA formation via hASH1-induced suppression of the apoptotic pathway. Our study yields a promising new preclinical tool for chemoprevention of peripheral lung carcinomas...
  78. ncbi Asthma control during the year after bronchial thermoplasty
    Gerard Cox
    St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    N Engl J Med 356:1327-37. 2007
    ..Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma...
  79. ncbi Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile
    Amadeu Gavaldá
    Almirall, Biology Department, R and D Center, Sant Feliu de Llobregat, Barcelona, Spain
    J Pharmacol Exp Ther 331:740-51. 2009
    ..2 versus 1.6). These results indicate that aclidinium is a potent muscarinic antagonist with a fast onset of action, a long duration of effect, and a favorable cardiovascular safety profile...
  80. pmc Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation
    Renee W Y Chan
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
    PLoS ONE 5:e8713. 2010
    ..the in vitro culture of the well differentiated NHBE cells acquired the physiological properties of normal human bronchi tissue which express high level of alpha2-6-linked sialic acid receptors and human airway trypsin-like (HAT) ..
  81. pmc Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cells
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:12439-49. 2007
    ..The attenuation of this critical host innate immune defense may contribute to the virulence of H5N1 viruses observed in humans...
  82. pmc Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    Camille Doe
    Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, England
    Chest 138:1140-7. 2010
    ..The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway inflammation, but their expression in asthma and COPD is uncertain...
  83. ncbi Increased levels of IgG to cytokeratin 19 in sera of patients with toluene diisocyanate-induced asthma
    Jung Hee Choi
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Ann Allergy Asthma Immunol 93:293-8. 2004
    ..Inhaled isocyanate binds with cytokeratin (CK) of the epithelial cells, which could induce immune responses...
  84. ncbi Proliferative aspects of airway smooth muscle
    Stuart J Hirst
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas School of Medicine, Guy s Hospital Campus, King s College London, United Kingdom
    J Allergy Clin Immunol 114:S2-17. 2004
    ..The maximum response of fluticasone propionate against thrombin-induced proliferation is increased when it is combined with salmeterol...
  85. ncbi Cytokine induction by respiratory syncytial virus and adenovirus in bronchial epithelial cells
    Jong Seo Yoon
    Department of Pediatrics, The Catholic University of Korea, Seoul, Republic of Korea
    Pediatr Pulmonol 42:277-82. 2007
    ..This study may help to explain the differences in the clinical outcomes of RSV and adenovirus infections...
  86. ncbi IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation
    Hazel C Atherton
    Novartis Respiratory Research Centre, Wimblehurst Rd, Horsham, West Sussex RH12 5AB, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 285:L730-9. 2003
    ..These data support the concept that IL-13 is in part able to induce a mucus hypersecretory phenotype through a direct interaction with the airway epithelium and that MAP kinase and PtdIns 3-kinase signaling pathways are involved...
  87. ncbi Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma
    Lena Uller
    The Brooke Laboratories, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 65:626-32. 2010
    ....
  88. ncbi Effect of bronchial colonisation on airway and systemic inflammation in stable COPD
    Alicia MarIn
    Department of Respiratory Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    COPD 9:121-30. 2012
    ....
  89. ncbi Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Am J Clin Pathol 126:725-35. 2006
    ..Our data suggest that COPD exhibits increased bronchial deposition of ECM proteins that contribute to deteriorated lung function and airway remodeling...
  90. pmc Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract
    Thijs Kuiken
    Departments of Virology and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Pathol 164:1893-900. 2004
    ..This study demonstrates that hMPV is a respiratory pathogen and indicates that viral replication is short-lived, polarized to the apical surface, and occurs primarily in ciliated respiratory epithelial cells...
  91. ncbi Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma
    Bryce N Feltis
    Caridio Respiratory Research Group, University of Tasmania, Hobart, Australia
    Am J Respir Crit Care Med 173:1201-7. 2006
    ..Although various growth factors have been implicated in modulating vascularity, the important contributors in vivo are still being elucidated. The most likely candidate is vascular endothelial growth factor (VEGF)...
  92. ncbi Immortalization of human small airway epithelial cells by ectopic expression of telomerase
    Chang Q Piao
    Center for Radiological Research, College of Physicians and Surgens, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Carcinogenesis 26:725-31. 2005
    ....
  93. ncbi Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease
    Satoshi Fuke
    First Department of Medicine, Hokkaido University School of Medicine, N 15, W 7, Kita ku, Sapporo, Japan, 060 8638
    Am J Respir Cell Mol Biol 31:405-12. 2004
    ....
  94. ncbi Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD
    A Di Stefano
    Division of Pulmonary Disease and Laboratory of Cytoimmunopathology of Heart and Lung, Salvatore Maugeri Foundation, IRCCS, Veruno, Italy
    Thorax 64:968-75. 2009
    ..Increased numbers of activated neutrophils have been reported in the bronchial mucosa of patients with stable chronic obstructive pulmonary disease (COPD), particularly in severe disease...
  95. ncbi Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation
    M Saetta
    Institute of Occupational Medicine, University of Padova, Italy
    Am J Respir Crit Care Med 161:1016-21. 2000
    ..05) compared with nonsmokers. In conclusion, smokers with both symptoms of chronic bronchitis and chronic airflow limitation have an increased number of goblet cells and inflammatory cells in the epithelium of peripheral airways...
  96. ncbi Airway smooth muscle hypertrophy and hyperplasia in asthma
    Alan L James
    Department of Pulmonary Physiology and Sleep Medicine West Australian Sleep Disorders Research Institute, Level 5, G Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia
    Am J Respir Crit Care Med 185:1058-64. 2012
    ..Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM)...
  97. ncbi Mini-plasmin found in the epithelial cells of bronchioles triggers infection by broad-spectrum influenza A viruses and Sendai virus
    M Murakami
    Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Japan
    Eur J Biochem 268:2847-55. 2001
    ..These findings suggest that mini-plasmin in the airway may play a pivotal role in the spread of viruses and their pathogenicity...
  98. ncbi Evolution of microRNA expression during human bronchial squamous carcinogenesis
    C Mascaux
    Institut Jules Bordet, Rue Heger Bordet 1, B 1000 Brussels, Belgium
    Eur Respir J 33:352-9. 2009
    ..The present data show, for the first time, that microRNAs are involved in bronchial carcinogenesis from the very early steps of this process and, thus, could provide tools for early detection of lung cancer...
  99. ncbi Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm
    Tomoyuki Fujisawa
    Center of Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA
    J Immunol 183:6236-43. 2009
    ..This is the first demonstration of the participation of NF-kappaB and its specific binding site in cytokine-mediated airway MUC5AC expression...
  100. ncbi A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway
    Zhang Bao
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore
    Am J Respir Crit Care Med 179:657-65. 2009
    ..Andrographolide, the principal active component of the medicinal plant Andrographis paniculata, has been shown to inhibit NF-kappaB activity...
  101. ncbi Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    Peter A B Wark
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, UK
    Respirology 14:180-6. 2009
    ..Infection with rhinovirus (RV) is the most common trigger for acute asthma and COPD. The aim of this study was to characterize the variability in the response of primary bronchial epithelial cells to infection with several strains of RV...

Research Grants62

  1. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..Studies comparing gene expression changes from invasive samples taken from the bronchi (lower airways) and non- invasive samples from the nose (upper airways) have shown many similarities...
  2. Transcriptional Control of Submucosal Gland Formation and Function
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..both the patterning and differentiation of airway epithelial cells (AECs) lining the developing trachea and bronchi, and the formation of submucosal glands (SMGs) that secrete the majority of fluids, electrolytes, and host ..
  3. Defining the role of mast cells during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2012
    ..the host response to respiratory infection with IAV, because they are found at elevated frequencies around the bronchi within the lungs...
  4. TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
    Mark E Lauer; Fiscal Year: 2013
    ..extensive hyaluronan-rich extracellular matrix produced by smooth muscle cells surrounding airway vasculature and bronchi. This hyaluronan (HA) matrix is abnormal in the sense that it is decorated with heavy chains (HCs) derived from a ..
  5. Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokines
    Albert Zlotnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mucosal sites include the oral cavity, trachea and bronchi, the digestive system and the female reproductive system...
  6. Progenitor Cells in Lung Development and Repair
    Brigid L M Hogan; Fiscal Year: 2013
    ..In Aim 2 we will focus on the adult trachea and main bronchi which has a pseudostratified epithelium, as in a large proportion of the human airways...
  7. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2012
    ..To address these aims, a mouse model will be used. The trachea, bronchi, and lungs with the vagus nerve and vagal sensory ganglia will obtained from mice actively sensitized to ..
  8. Broncho-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2013
    ..Prior to the techniques developed in this project, drugs were administered to bronchi with swabs or crude biopsy needles...
  9. Exhaled Nitric Oxide: Mechanisms and Limitations
    STEVEN CARL GEORGE; Fiscal Year: 2010
    ..We hypothesize that ventilation and inflammation heterogeneity in both the conducting airways (bronchi and bronchioles) and the acinar region (respiratory bronchioles to alveoli) of the lungs impacts the exhaled ..
  10. Development of a method for in situ nanorheology of human airway mucus
    Amy L Oldenburg; Fiscal Year: 2013
    ..Subsequently, we will validate this technique using non- muco-adherent GNRs in mucus harvested from human bronchi-epithelial (hBE) cultures, and evaluate the response as a function of % solids...
  11. CysLT and P2Y Receptors in Lung Inflammation
    Joshua A Boyce; Fiscal Year: 2012
    ..generate cys-LTs) and CysLT1 receptor-null mice completely lack MCs in the inflamed epithelial surfaces of the bronchi. Moreover, we have demonstrated that both cys-LTs and a nucleotide, UDP, behave as co-mitogenic growth factors ..
  12. A mouse model of stem cell deregulation and lung cancer
    JOSEPH LOCKER LOCKER; Fiscal Year: 2010
    ..First apparent in the distal lung buds, the cells spread upward throughout the bronchi and trachea, and eventually formed separate cell populations in the tracheo- bronchial and bronchioloalveolar ..
  13. MicroFlex Technology for Early Detection of Lung Disease
    DALE A LAWRENCE; Fiscal Year: 2013
    ..for bronchoscopes, enabling minimally invasive bronchoscopy to reach previously inaccessible peripheral bronchi and provide direct visualization and tool manipulation capabilities for diagnostic and therapeutic procedures...
  14. ASPERGILLUS ELASTASE, A POTENTIAL VIRULENCE FACTOR
    JUDITH RHODES; Fiscal Year: 1990
    ..has been well described: following germination, the hyphae elongate and spread rapidly, penetrating vessels and bronchi in their path...
  15. PARS inhibitor therapy for smoke inhalation
    Andrew Salzman; Fiscal Year: 2004
    ..of trauma, carbonaceous sputum, an early decrease in PF ratio, blood tinged endotracheal secretions, or blackened bronchi by bronchoscopic exam), and 4) clinical judgment by the patient's physician that there is a high probability that ..
  16. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2002
    ..cause epidermolytic palmoplantar keratoderma, a skin disease linked to familial internal malignancies (esophagus, bronchi, breast and ovary). The working hypotheses in this proposal are: 1...
  17. Improved Lung Delivery of Medical Aerosols through Enhanced Condensation Growth
    P Worth Longest; Fiscal Year: 2010
    ..region and apply the model to evaluate aqueous wall boundary conditions and transport into distal bronchi. Specific Aim 3: Employ the developed in vitro and CFD models to test the effects of (1) transient flow, (2) ..
  18. Bronchio-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2009
    ..These diseases of the bronchi each may potentially be treated with local, direct infusion of medications into the bronchial wall and adventitia ..
  19. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1993
    ..perfuses an extensive microvascular plexus in the submucosa and adventitia of large airways and parenchymal bronchi. Inflammatory mediators, e.g...
  20. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2004
    ..Control of smooth muscle in the trachea and bronchi is predominantly by nerve fibers that emanate from neuronal cell bodies in parasympathetic ganglia, small ..
  21. CF TS TRANSFORMANTS--BIOCHEMICAL AND GENETIC ANALYSIS
    Dieter Gruenert; Fiscal Year: 1992
    ..Clones of transformed CF epithelial cells will be derived from trachea, bronchi, submucosa, and nasal polyps...
  22. SYSTEMATIC STUDY OF THE BRONCHIAL CIRCULATION
    MICHAEL MAGNO; Fiscal Year: 1980
    ..In the sheep, the carinal artery is the major source of blood flow to all the intrapulmonary bronchi except those in the right apical lobe...
  23. AUTONOMIC-EPITHELIAL INTERACTIONS IN AIRWAY DISEASE
    Richard Broadstone; Fiscal Year: 1990
    ..In vitro, trachealis muscle strips and bronchial rings from three generations of bronchi will be suspended in organ baths...
  24. Image-guided catheter biopsy of peripheral lung cancer
    Eric Seibel; Fiscal Year: 2005
    DESCRIPTION (provided by applicant) Transbronchial needle aspiration and cytological brush sampling of the bronchi are the methods of choice for early diagnosis of lung cancer...
  25. CysLt and P2Y Receptors and Lung Inflammation
    Joshua Boyce; Fiscal Year: 2007
    ..generate cys-LTs) and CysLTI receptor-null mice virtually lack MCs in the inflamed epithelial surfaces of the bronchi and gut...
  26. REGIONAL ION TRANSPORT ACROSS AIRWAY EPITHELIUM
    STEPHEN BALLARD; Fiscal Year: 1999
    ..on airway liquid balance are supported by findings that accessible large airways, such as trachea and large bronchi, actively absorb ions (driven by active Na+ absorption)...
  27. Computer Assisted Ultrathin Brochoscopy
    David Naidich; Fiscal Year: 2006
    ..lung nodules, including the use of pulmonary arteries as surrogate markers for the location of peripheral bronchi in those cases in which bronchi cannot be identified adjacent to lesions even using high-resolution near-..
  28. MATHEMATICAL MODELS OF BRANCHING IN THE HUMAN LUNG
    Henry Feldman; Fiscal Year: 1980
    The objective of this study will be to develop a mathematical model for the asymmetric branching pattern of bronchi in the human lung...
  29. MU cells in mammalian conjunctiva
    Thomas Phillips; Fiscal Year: 2003
    ..of M cells have been found in the epithelium overlying mucosa-associated lymphoid tissue in the intestine, bronchi, nasal cavity, and tonsils...
  30. DEVELOPMENT AND DIFFERENTIATION OF AIRWAY EPITHELIUM
    ELIZABETH MC DOWELL; Fiscal Year: 1991
    ..The major goal is to compare and contrast the development of bronchi and bronchioles in fetal and neonatal hamsters developing during hyper-, hypo- and euglycemic pregnancies...
  31. Detection of Lung Cancer via Registered Temporal Images
    YUNG MING LURE; Fiscal Year: 2004
    ..in segmentation of ribs in chest radiography and segmentation of lung structures including large and medium size bronchi and blood vessels in thoracic CT...
  32. Lung Delivery of Nebulized Tissue Plasminogen Activator
    KATHLEEN STRINGER; Fiscal Year: 2003
    ..lung replica reproduced from a master cast made from a human cadaver which includes five to nine generations of bronchi will be utilized...
  33. LUNG RESPONSES TO CONSTRICTOR AGONISTS
    Felix Shardonofsky; Fiscal Year: 2002
    ..pressure relationships of bronchial segments in situ with length-axial tension relationships of excised bronchi during different static and dynamic loads...
  34. The Gene Expression Program of Mouse Lung Development
    Mark Krasnow; Fiscal Year: 2006
    ..The lung begins development as a pair of air tubes (bronchi) which are surrounded by a primitive network of blood vessels...
  35. Generation of Cell Diversity in Mouse Lung Development
    Brigid Hogan; Fiscal Year: 2007
    ..For example, the proximal trachea, bronchi and bronchioles contain ciliated, secretory, and neuroendocrine cells, while the distal (terminal) alveoli ..
  36. Computer-Aided Diagnosis to Enhance Thoracic CT Imaging
    YUNG MING LURE; Fiscal Year: 2001
    ..rapidly and efficiently; (3) to identify the malignancy of nodules by determining and removing vessels and bronchi connecting with nodule suspects; and (4) to provide other CAD functions to enhance the display capability for ..
  37. INTERACTIONS BETWEEN MAST CELLS & NERVES IN AIRWAYS
    Bradley Undem; Fiscal Year: 1992
    ..Mast cell function in central airways will be investigated using human bronchi and guinea pig trachea and bronchi...
  38. A Smart Inhaler System for Maximum Drug Aerosol Delivery
    STEFAN SEELECKE; Fiscal Year: 2006
    ..Particle fluxes will be measured through the bronchi down to the 4th generation under controlled and reproducible conditions...
  39. A Smart Inhaler System for Maximum Drug Aerosol Delivery
    STEFAN SEELECKE; Fiscal Year: 2005
    ..Particle fluxes will be measured through the bronchi down to the 4th generation under controlled and reproducible conditions...
  40. The Airway Transcriptome as a Biomarker for Lung Cancer
    Avrum Spira; Fiscal Year: 2006
    ..will characterize the patterns of gene expression in epithelial cells obtained by brushing intrathoracic (lobar bronchi) airway in smokers with and without lung cancer...
  41. PROTEOGLYCANS OF ANIMAL LUNG PARENCHYMA
    VITTORIO PEDRINI; Fiscal Year: 1980
    ..for the extraction and purification of proteoglycans from fresh bovine lung after carefully removing all bronchi and large blood vessels...
  42. DEVELOPMENTAL LUNG TOXICOLOGY & THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2009
    ..This work will further our understanding of the basic molecular mechanisms by which environmental insults are involved in the origins of lung diseases that begin in childhood. ..
  43. AUTONOMIC REGULATION OF AIRWAY SMOOTH MUSCLE TONE
    BRENDAN CANNING; Fiscal Year: 2001
    ..It is anticipated that this information will improve our understanding of the role of the autonomic innervation of the healthy and diseased lung. ..
  44. KININS AS MEDIATORS OF HUMAN REACTIONS
    BRENDAN CANNING; Fiscal Year: 2003
    ..These rigorous studies will not only clarify the role of BK in airway diseases, but will also have broader relevance by providing new and important insights into how neural function is altered in asthma and rhinitis. ..
  45. Reflexes and Supraesophageal Consequences of Reflux Disease
    Brendan J Canning; Fiscal Year: 2010
    ..This research may also help identify novel therapeutic strategies for treating both GERD and chronic cough. ..
  46. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005
    ....
  47. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  48. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  49. Gonadal vs. Genomic Influences on Xenobiotic Metabolism
    LAURA VAN WINKLE; Fiscal Year: 2008
    ..The proposed studies are relevant to diseases associated with pulmonary remodeling and PAH activation, such as lung cancer. ..
  50. AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS
    Y S Prakash; Fiscal Year: 2001
    ....
  51. Preterm birth, lung innate immunity, and RSV
    Mark Ackermann; Fiscal Year: 2009
    ..The work is significant because it discovers the underlying basis for RSV susceptibility preterm and mechanistic approaches to enhance innate immunity. ..
  52. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2009
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  53. Prenatal Tobacco Smoke and Expression in Airways
    LAURA VAN WINKLE; Fiscal Year: 2006
    ..These studies will thus address the fetal basis of adult diseases of the lung caused by exposure in utero to environmental tobacco smoke. ..
  54. CONFERENCE ON PARTICULATE AIR POLLUTION AND HUMAN HEALTH
    Robert Phalen; Fiscal Year: 2003
    ..To add significantly to the peer-reviewed literature by publishing research results presented at the conference in a variety of special issues of selected journals. ..
  55. Acquisition of LMD6000 Laser Microdissection Unit
    LAURA VAN WINKLE; Fiscal Year: 2008
    ..The overall benefits to the UC Davis campus are many. This equipment fits well with the research needs of the UC Davis community, which has included a recent emphasis on genomics. [unreadable] [unreadable] [unreadable]..
  56. Cloning Kawasaki Disease-specific antigens
    Anne Rowley; Fiscal Year: 2005
    ..These plans will provide me with opportunities for enhanced career development by acquisition of new research skills, and will be fostered by the strong interdisciplinary research environment at Northwestern. ..
  57. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  58. Genetic Control of Pulmonary Cavities in Tuberculosis
    Robert Hunter; Fiscal Year: 2005
    ..If successful, new insights into the pathogenesis of pulmonary cavities may lead to specific interventions to prevent this highly infectious disease manifestation. ..
  59. CONFOCAL MICROSCOPE
    Mark Ackermann; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. A proteomics approach in the study of novel COPD markers
    Ratko Djukanovic; Fiscal Year: 2005
    ..Finally, applying the antibodies to archival lung tissue samples we will be able to localize the COPD-selective proteins to the airway and alveoli, adding valuable knowledge to our understanding of COPD mechanisms. ..