lung

Summary

Summary: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

Top Publications

  1. doi Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico
    Rogelio Perez-Padilla
    National Institute of Respiratory Diseases, Mexico City, Mexico
    N Engl J Med 361:680-9. 2009
  2. pmc MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15805-10. 2007
  3. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
  4. pmc MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
    Mattia Boeri
    Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, and Unit of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 108:3713-8. 2011
  5. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  6. ncbi Standardisation of the measurement of lung volumes
    J Wanger
    Internal Medicine, University of Genoa, V le Benedetto XV, 6, I 16132 Genova, Italy
    Eur Respir J 26:511-22. 2005
  7. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
  8. pmc Lung infections associated with cystic fibrosis
    Jeffrey B Lyczak
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Clin Microbiol Rev 15:194-222. 2002
  9. pmc Contribution of neutrophils to acute lung injury
    Jochen Grommes
    Department of Vascular Surgery, University Hospital, RWTH Aachen, Germany
    Mol Med 17:293-307. 2011
  10. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003

Research Grants

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
  2. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
  3. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
  4. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
  5. James D Bryers; Fiscal Year: 2016
  6. Carole R Mendelson; Fiscal Year: 2016
  7. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
  8. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
  9. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
  10. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013

Detail Information

Publications500 found, 100 shown here

  1. doi Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico
    Rogelio Perez-Padilla
    National Institute of Respiratory Diseases, Mexico City, Mexico
    N Engl J Med 361:680-9. 2009
    ....
  2. pmc MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15805-10. 2007
    ..We and others have shown that expression profiles of miRNAs are different in lung cancer vs. normal lung, although the significance of this aberrant expression is poorly understood...
  3. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    Chronic obstructive pulmonary disease (COPD) is characterised by both an accelerated decline in lung function and periods of acute deterioration in symptoms termed exacerbations...
  4. pmc MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
    Mattia Boeri
    Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, and Unit of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 108:3713-8. 2011
    The efficacy of computed tomography (CT) screening for early lung cancer detection in heavy smokers is currently being tested by a number of randomized trials...
  5. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  6. ncbi Standardisation of the measurement of lung volumes
    J Wanger
    Internal Medicine, University of Genoa, V le Benedetto XV, 6, I 16132 Genova, Italy
    Eur Respir J 26:511-22. 2005
  7. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
    ..There is no direct evidence of a protective role of TNF-alpha in patients with tuberculosis...
  8. pmc Lung infections associated with cystic fibrosis
    Jeffrey B Lyczak
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Clin Microbiol Rev 15:194-222. 2002
    ..factors have led to the successful management of many CF-related infections with the notable exception of chronic lung infection with the gram-negative bacterium Pseudomonas aeruginosa. The virulence of P...
  9. pmc Contribution of neutrophils to acute lung injury
    Jochen Grommes
    Department of Vascular Surgery, University Hospital, RWTH Aachen, Germany
    Mol Med 17:293-307. 2011
    Treatment of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), remain unsolved problems of intensive care medicine...
  10. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
    ..BLM)-resistant BALB/c mice into female BLM-sensitive C57BL/6 recipients and quantified engraftment levels in lung by real-time PCR. Male DNA accounted for 2...
  11. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
    ..Pulmonary fibrosis was originally thought to be mediated solely by resident lung fibroblasts...
  12. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
    ..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
  13. pmc Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    Mauricio Rojas
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Department of Medicine, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 33:145-52. 2005
    We sought to determine whether an intact bone marrow is essential to lung repair following bleomycin-induced lung injury in mice, and the mechanisms of any protective effects conferred by bone marrow-derived mesenchymal stem cell (BMDMSC) ..
  14. pmc Animal models of acute lung injury
    Gustavo Matute-Bello
    Medical Research Service of the Veterans Affairs Puget Sound Health Care System, 815 Mercer St, Seattle, WA 98109, USA
    Am J Physiol Lung Cell Mol Physiol 295:L379-99. 2008
    Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi...
  15. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..We hypothesized that IL-17 receptor (IL-17R) signaling is critical for G-CSF and CXC chemokine production and lung host defenses...
  16. pmc Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:535-52. 2010
    ..Together, these studies identify a critical role for IL-17A in fibrosis, illustrating the potential utility of targeting IL-17A in the treatment of drug and inflammation-induced fibrosis...
  17. pmc Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts
    Yonghua Zheng
    Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    J Cell Mol Med 17:567-77. 2013
    ..In this study, the gene expression profile of murine lung TCs is compared with other differentiated interstitial cells (fibroblasts) and with stromal stem/progenitor cells...
  18. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  19. pmc H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000115. 2008
    ..associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate...
  20. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue...
  21. doi A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Ministry of Education MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
    Nat Genet 43:792-6. 2011
    b>Lung cancer is the leading cause of cancer-related deaths worldwide...
  22. pmc PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    Seung Hee Yoo
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:5339-46. 2004
    ..These results demonstrate that peripheral tissues express self-sustained, rather than damped, circadian oscillations and suggest the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level...
  23. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
    ..The background corrected pulmonary (13)C added as ultrafine (13)C particles on day 1 postexposure was 1.34 microg/lung. Lung (13)C concentration decreased from 1.39 microg/g (day 1) to 0.59 microg/g by 7 days postexposure...
  24. pmc Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    Tirumalai Rangasamy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 114:1248-59. 2004
    ..Susceptibility of the lung to oxidative injury, such as that originating from inhalation of CS, depends largely on its upregulation of ..
  25. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
    Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality...
  26. pmc miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1589-97. 2010
    ..of miRNAs is known to be involved in a variety of pathophysiologic processes, the role of miRNAs in fibrotic lung diseases is unclear...
  27. pmc The branching programme of mouse lung development
    Ross J Metzger
    Department of Biochemistry and HHMI, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nature 453:745-50. 2008
    ..is generated by three geometrically simple local modes of branching used in three different orders throughout the lung. We propose that each mode of branching is controlled by a genetically encoded subroutine, a series of local ..
  28. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    ..Here, we tested the therapeutic capacity of human MSCs to restore alveolar epithelial fluid transport and lung fluid balance from acute lung injury (ALI) in an ex vivo perfused human lung preparation injured by E...
  29. pmc IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    Shean J Aujla
    Children s Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:275-81. 2008
    ..Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury...
  30. pmc LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
    Martin C Herzig
    Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Hum Mol Genet 20:4209-23. 2011
    ..marked increase in number and size of secondary lysosomes in kidney proximal tubule cells and lamellar bodies in lung type II cells...
  31. pmc IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    PLoS ONE 6:e28457. 2011
    ..Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood...
  32. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused chemokine production and leukocyte infiltration...
  33. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
    ..After 2 x 10(6) hMSCs were i.v. infused into mice, most of the cells were trapped as emboli in lung. The cells in lung disappeared with a half-life of about 24 hr, but <1000 cells appeared in six other tissues...
  34. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
    ..in vivo effector functions, the Clara cell 10-kDa protein promoter was used to express IL-13 selectively in the lung, and the phenotype of the resulting transgenic mice was characterized...
  35. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
    ..Thus, caveolin-1 and caveolae play a fundamental role in organizing multiple signaling pathways in the cell...
  36. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  37. pmc TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    Laura McKinley
    Department of Pediatrics, Lung Immunology and Host Defense Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:4089-97. 2008
    ..of T(H)2 cells to mice challenged with OVA protein resulted in lymphocyte and eosinophil emigration into the lung that was markedly reduced by DEX treatment, whereas T(H)17 transfer resulted in increased CXC chemokine secretion ..
  38. pmc Preparing for the first breath: genetic and cellular mechanisms in lung development
    Edward E Morrisey
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 18:8-23. 2010
    ..The lung itself consists of two highly branched, tree-like systems--the airways and the vasculature--that develop in a ..
  39. doi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome...
  40. pmc Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112
    Joshua D Hall
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Infect Immun 76:5843-52. 2008
    ..These results demonstrate directly that F. tularensis is a promiscuous intracellular pathogen in the lung that invades and replicates within cell types ranging from migratory immune cells to structural tissue cells...
  41. doi Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1
    Bo Xu
    Department of Respiratory Medicine, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing, China
    J Surg Res 166:e157-64. 2011
    ..We have shown that IPO can attenuate lung IRI by up-regulating the protein expression of heme oxygenase-1(HO-1)...
  42. doi Non-small-cell lung cancer
    Peter Goldstraw
    Academic Department of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Imperial College School of Medicine, London, UK
    Lancet 378:1727-40. 2011
    In the decade since the last Lancet Seminar on lung cancer there have been advances in many aspects of the classification, diagnosis, and treatment of non-small-cell lung cancer (NSCLC)...
  43. pmc Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung
    Xiang Wang
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, United States
    ACS Nano 5:9772-87. 2011
    ..that allows quantitative assessment of dispersion on profibrogenic responses in tissue culture cells and in mouse lung. We demonstrate that the dispersal of as-prepared (AP), purified (PD), and carboxylated (COOH) MWCNTs by bovine ..
  44. ncbi Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
    Darwyn Kobasa
    Respiratory Viruses, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 445:319-23. 2007
    ..The ability of influenza viruses to modulate host immune responses, such as that demonstrated for the avian H5N1 influenza viruses, may be a feature shared by the virulent influenza viruses...
  45. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
    ..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
  46. ncbi Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    K B Lane
    Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Nat Genet 26:81-4. 2000
    ..Our data demonstrate the molecular basis of FPPH and underscore the importance in vivo of the TGF-beta signalling pathway in the maintenance of blood vessel integrity...
  47. pmc Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    Marco Chilosi
    Department of Pathology, University of Verona, Verona, Italy
    Am J Pathol 162:1495-502. 2003
    ..fibrosis/usual interstitial pneumonia (IPF/UIP), we analyzed the expression patterns of beta-catenin on 20 IPF/UIP lung samples, together with two downstream target genes of Wnt signaling, cyclin-D1, and matrilysin...
  48. pmc Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease
    Steven Bozinovski
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia 3010
    Proc Natl Acad Sci U S A 109:935-40. 2012
    ..Human lung macrophages (CD68(+)) colocalized with SAA and GCs markedly increased SAA in vitro (THP-1, pEC(50) 43 nM)...
  49. doi miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer
    Kristen M Foss
    Translational Genomics Research Institute, Phoenix, Arizona, USA
    J Thorac Oncol 6:482-8. 2011
    The ability to diagnose non-small cell lung cancer (NSCLC) at an early stage may lead to improved survival...
  50. pmc Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
    Jae W Lee
    Department of Anesthesiology, University of California San Francisco, California 94143, USA
    Stem Cells 29:913-9. 2011
    Morbidity and mortality have declined only modestly in patients with clinical acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), despite extensive research into the pathophysiology...
  51. pmc Analysis of the lung microbiome in the "healthy" smoker and in COPD
    John R Erb-Downward
    University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e16384. 2011
    Although culture-independent techniques have shown that the lungs are not sterile, little is known about the lung microbiome in chronic obstructive pulmonary disease (COPD)...
  52. pmc Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    Laurel A Monticelli
    Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:1045-54. 2011
    ..Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain ..
  53. ncbi Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
    ..as well as in the biochemical and functional phenotypes of each of the vascular cell types, from the hilum of the lung to the most peripheral vessels in the alveolar wall...
  54. doi A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
    Robert J Snelgrove
    Imperial College London, Kennedy Institute, London, W6 8LH, UK
    Nat Immunol 9:1074-83. 2008
    The lung must maintain a high threshold of immune 'ignorance' to innocuous antigens to avoid inflammatory disease that depends on the balance of positive inflammatory signals and repressor pathways...
  55. doi Reconstituting organ-level lung functions on a chip
    Dongeun Huh
    Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA
    Science 328:1662-8. 2010
    ..a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory ..
  56. ncbi Discordant protein and mRNA expression in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 1:304-13. 2002
    ..In this study, we compared mRNA and protein expression for a cohort of genes in the same lung adenocarcinomas...
  57. ncbi Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    Anna A Shvedova
    Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
    Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005
    ..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage...
  58. pmc Regression of murine lung tumors by the let-7 microRNA
    P Trang
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Oncogene 29:1580-7. 2010
    ..Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor...
  59. doi High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer
    Xiao Guang Liu
    Department of Joint Laboratory of Immunogenomics, Zhoushan Hospital BIG CAS, Zhejiang 316004, China
    Med Oncol 29:618-26. 2012
    ..In addition, this study, for the first time, identifies a significant role of the tumor miR-200c played in predicting prognosis in patients with NSCLC...
  60. pmc Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection
    Bruno Moltedo
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 7:e1002345. 2011
    Migratory lung dendritic cells (DCs) transport viral antigen from the lungs to the draining mediastinal lymph nodes (MLNs) during influenza virus infection to initiate the adaptive immune response...
  61. pmc Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses
    Charles S Dela Cruz
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 12:34-46. 2012
    ..S. pneumoniae-infected Chi3l1 null mice exhibit exaggerated lung injury, inflammation and hemorrhage, more frequent bacterial dissemination, decreased bacterial clearance, and ..
  62. doi T cells become licensed in the lung to enter the central nervous system
    Francesca Odoardi
    Institute for Multiple Sclerosis Research, Department of Neuroimmunology, Gemeinnützige Hertie Stiftung and University Medical Centre Göttingen, 37073 Gottingen, Germany
    Nature 488:675-9. 2012
    ..intravenously transferred T-cell blasts gain the capacity to enter the CNS after residing transiently within the lung tissues...
  63. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010
    ..We demonstrate that Batf3(-/-) mice also lack CD103+CD11b- DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes...
  64. ncbi Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    Sachie Hiratsuka
    Department of Pharmacology, Tokyo Women s Medical University School of Medicine, Shinjyuku ku, Tokyo 162 8666, Japan
    Nat Cell Biol 8:1369-75. 2006
    ..is induced by distant primary tumours, attract Mac 1 (macrophage antigen 1)(+)-myeloid cells in the premetastatic lung. In addition, tumour cells use this mechanism, through activation of the mitogen-activated protein kinase (MAPK) ..
  65. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ..mice was accompanied by (i) increased (>200-fold) viral replication, (ii) greater influx of neutrophils into the lung, (iii) increased numbers of alveolar macrophages (AMs), and (iv) increased protein expression of cytokines and ..
  66. pmc Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury
    Axelle Caudrillier
    Cardiovascular Research Institute, UCSF, San Francisco, CA, USA
    J Clin Invest 122:2661-71. 2012
    ..that activated platelets induce the formation of neutrophil extracellular traps (NETs) in transfusion-related acute lung injury (TRALI), which is the leading cause of death after transfusion therapy...
  67. doi Functional disability 5 years after acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada
    N Engl J Med 364:1293-304. 2011
    ..There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS)...
  68. pmc TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1715-24. 2005
    ..These findings reveal a previously unappreciated role for TLR9 in the host response to M. tuberculosis and illustrate TLR collaboration in host resistance to a major human pathogen...
  69. ncbi Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
    M Neeper
    Department of Cellular and Molecular Biology, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
    J Biol Chem 267:14998-5004. 1992
    ..A approximately 35-kDa polypeptide with a unique NH2-terminal sequence has been isolated from bovine lung and found to be present on the surface of endothelial cells where it mediates the binding of AGEs (receptor for ..
  70. pmc Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells
    Marianne Geiser
    Institute for Anatomy, University of Bern, Bern, Switzerland
    Environ Health Perspect 113:1555-60. 2005
    ..Inhaled ultrafine titanium dioxide particles were found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries...
  71. ncbi By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Cell 115:13-23. 2003
    Surfactant proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a globular head domain that binds PAMPs and a collagenous tail domain that initiates phagocytosis...
  72. pmc Requirement of bic/microRNA-155 for normal immune function
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 316:608-11. 2007
    ..We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling...
  73. pmc Significance of the microbiome in obstructive lung disease
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:456-63. 2012
    The composition of the lung microbiome contributes to both health and disease, including obstructive lung disease...
  74. ncbi Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:4867-78. 1997
    During mouse lung morphogenesis, the distal mesenchyme regulates the growth and branching of adjacent endoderm...
  75. pmc Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus
    T C Dawson
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 156:1951-9. 2000
    ....
  76. ncbi Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts
    Sergei P Atamas
    Baltimore VA Medical Center, Research Service 151, Room 3C 125, 10 North Greene Street, Baltimore, MD 21201, USA
    Am J Respir Cell Mol Biol 29:743-9. 2003
    ..whether PARC could be directly involved in development of pulmonary fibrosis by stimulating collagen production in lung fibroblasts...
  77. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    ..boosted intradermally make very strong splenic CD4 and CD8 Th1 cytokine responses to Ag 85A, but show no change in lung mycobacterial burden over BCG primed animals...
  78. ncbi Automatic lung segmentation from thoracic computed tomography scans using a hybrid approach with error detection
    Eva M van Rikxoort
    Image Sciences Institute, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Med Phys 36:2934-47. 2009
    b>Lung segmentation is a prerequisite for automated analysis of chest CT scans. Conventional lung segmentation methods rely on large attenuation differences between lung parenchyma and surrounding tissue...
  79. pmc Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 31:894-901. 2010
    ..The expression of 576 miRNAs was evaluated by miRNA microarray in liver and lung. In sham-exposed mice, the expression of miRNAs tended to be higher in liver than in lung...
  80. pmc Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer
    Roya Navab
    The Campbell Family Institute for Cancer Research, Ontario Cancer Institute at Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 108:7160-5. 2011
    ..CAFs) in these processes and their clinical impact has not been studied systematically in non-small cell lung carcinoma (NSCLC)...
  81. doi Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
    Denis E O'Donnell
    Queen s University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Respir Med 105:1030-6. 2011
    ..This study investigated the effect of indacaterol on exercise endurance, and on lung hyperinflation during exercise and at rest in patients with moderate-to-severe COPD.
  82. pmc CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen
    A Nicole Desch
    Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA
    J Exp Med 208:1789-97. 2011
    ..In the lung, there are two primary DC subsets with the potential to migrate to the local lymph nodes (LNs) and initiate ..
  83. pmc Tumor entrained neutrophils inhibit seeding in the premetastatic lung
    Zvi Granot
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Cancer Cell 20:300-14. 2011
    ..Here we demonstrate that neutrophils accumulate in the lung prior to the arrival of metastatic cells in mouse models of breast cancer...
  84. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
  85. pmc Basal cells as stem cells of the mouse trachea and human airway epithelium
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 106:12771-5. 2009
    ..profile identified 2 cell-surface markers, ITGA6 and NGFR, which can be used in combination to purify human lung basal cells by FACS...
  86. pmc Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations
    Philip H Quanjer
    Dept of Pulmonary Diseases and Dept of Paediatrics, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands
    Eur Respir J 40:1324-43. 2012
    ..Over 160,000 data points from 72 centres in 33 countries were shared with the European Respiratory Society Global Lung Function Initiative...
  87. ncbi The role of transforming growth factor beta in lung development and disease
    Ulrike Bartram
    University Children s Hospital, Josef Schnewider Strasse 2, 97080 Wuerzburg, Germany
    Chest 125:754-65. 2004
    ..factor (TGF) beta plays an important role in normal pulmonary morphogenesis and function and in the pathogenesis of lung disease...
  88. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    ..but are near the hedgehog-interacting protein (HHIP) gene and several expressed sequence tags cloned from fetal lung. Though it is unclear what gene or regulatory effect explains the association, the region warrants further ..
  89. ncbi The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary
    S Kimura
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 10:60-9. 1996
    ..animals developed normally, whereas mice homozygous for the disrupted gene were born dead and lacked the lung parenchyma...
  90. pmc Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells
    Tyler A Longmire
    Boston University Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    Cell Stem Cell 10:398-411. 2012
    Two populations of Nkx2-1(+) progenitors in the developing foregut endoderm give rise to the entire postnatal lung and thyroid epithelium, but little is known about these cells because they are difficult to isolate in a pure form...
  91. pmc Targeting of low-dose CT screening according to the risk of lung-cancer death
    Stephanie A Kovalchik
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, and Information Management Services, Rockville, MD, USA
    N Engl J Med 369:245-54. 2013
    In the National Lung Screening Trial (NLST), screening with low-dose computed tomography (CT) resulted in a 20% reduction in lung-cancer mortality among participants between the ages of 55 and 74 years with a minimum of 30 pack-years of ..
  92. pmc IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
    Jan Eric Turner
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Exp Med 210:2951-65. 2013
    ..Here we focus on the role of IL-9 and ILC2s during the lung stage of infection with Nippostrongylus brasiliensis, which results in substantial tissue damage...
  93. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..demonstrate that respiratory infection with influenza virus results in the activation of NLR inflammasomes in the lung. Although NLRP3 was required for inflammasome activation in certain cell types, CD4 and CD8 T cell responses, as ..
  94. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..We generated lung-targeted VEGF(165) transgenic mice and evaluated the role of VEGF in T-helper type 2 cell (T(H)2)-mediated ..
  95. pmc Oral tolerance in the absence of naturally occurring Tregs
    Daniel Mucida
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 115:1923-33. 2005
    ..immunization prevented effector/memory Th2 cell development, germinal center formation, class switching to IgE, and lung inflammation...
  96. doi Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection
    Keer Sun
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208, USA
    Nat Med 14:558-64. 2008
    ..a common cause of severe disease in humans, yet the mechanisms responsible for this viral-bacterial synergy in the lung are only poorly understood...
  97. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    To directly test the contribution of Scgb1a1(+) Clara cells to postnatal growth, homeostasis, and repair of lung epithelium, we generated a Scgb1a1-CreER "knockin" mouse for lineage-tracing these cells...
  98. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
    ..virus and monitored for morbidity, mortality, viral replication, hemostatic parameters, cytokine production, and lung histology...
  99. pmc Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis
    Shahin Shafiani
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 207:1409-20. 2010
    ..of delaying the priming of effector CD4(+) and CD8(+) T cells in the pLN and their subsequent accumulation in the lung, the primary site of infection...
  100. ncbi The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    O Hori
    Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 270:25752-61. 1995
    ..Sequential chromatography of bovine lung extract identified polypeptides with M(r) values of approximately 12,000 (p12) and approximately 23,000 (p23) which ..
  101. pmc Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression
    Suhaida A Selamat
    Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Genome Res 22:1197-211. 2012
    b>Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its most common histological subtype...

Research Grants80

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..These cross-sectional studies will be follow-up with additional longitudinal analyses from the Lung Health Study in 2011-2014...
  3. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..These cross-sectional studies will be follow-up with additional longitudinal analyses from the Lung Health Study in 2011-2014...
  4. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..acute episodes in the hospital;the role of chronic sinus disease;and most recently the effects of pH changes in the lung lining fluid...
  5. James D Bryers; Fiscal Year: 2016
    ..Well-recognized infections involving biofilms include bacterial endocarditis, cystic fibrosis lung infections, deep wound healing, the current dental caries epidemic, periodontal disease, vaginosis, urinary tract ..
  6. Carole R Mendelson; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Surfactant protein A (SP-A) is developmentally regulated in fetal lung type II cells in concert with surfactant phospholipid synthesis and, thus, serves as an excellent marker of type II cell ..
  7. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Acute lung injury (ALI) precedes the development of MOF in 83% of cases, occurs in up to 37% of patients following trauma and ..
  8. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Radikal Therapeutics (RTX) is developing a novel bifunctional small molecule, R-503, intended for the prevention of lung ischemia-reperfusion injury (LIRI) associated with orthotopic lung transplantation...
  9. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    I. The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a large scale, randomized controlled trial to determine whether certain screening tests will reduce the number of deaths from these cancers...
  10. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a large scale, randomized controlled trial to determine whether certain screening tests will reduce the number of deaths from these cancers...
  11. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Tissue levels of R-100 and metabolites from heart, lung, kidney, and liver will be measured, in order to relate plasma and organ drug uptake...
  12. Bandana Chatterjee; Fiscal Year: 2016
    ..men, and metastatic prostate cancer is a leading cause of cancer death in men in the USA, second only to death from lung cancer. Risk for the disease rises from the 5th decade of life...
  13. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Furthermore, UBC9 is overexpressed in several malignancies, such as lung adenocarcinoma, ovarian carcinoma, and melanoma...
  14. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..data that ajulemic acid, a non-psychotropic nanomolar CB1/ CB2 agonist is highly effective in preventing skin and lung fibrosis in a mouse bleomycin model of scleroderma and inhibits extracellular matrix production by dermal ..
  15. Jian Min Yuan; Fiscal Year: 2014
    ..cohorts to elucidate the role of environmental exposure, genetic variants and DNA methylation in the development of lung or liver cancer...
  16. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  17. Roby Greenwald; Fiscal Year: 2016
    ..The investigators will use non-invasive approaches to assess acute changes in lung function and airway oxidative stress...
  18. Stephen E McGowan; Fiscal Year: 2016
    ..and expansion of the alveolar capillary network requires cooperation among endothelial cells, pericytes, and lung fibroblasts (LF)...
  19. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..g. kidney and lung) in which a significant number of the same cells resides...
  20. Craig T Morita; Fiscal Year: 2016
    ..Cancer causes ~13% of human deaths with 7.6 million people dying from cancer in 2007. More people in the US die of lung cancer than breast, colon, kidney, and prostate cancers combined...
  21. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..cadmium (Cd), a heavy metal, either from occupational contamination or from cigarette smoke, induces emphysema and lung cancers. However, the mechanisms for Cd-elicited lung pathology remain poorly understood...
  22. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..subsequent cleavage of extracellular matrix generates a chemoattractant that drives neutrophil migration into the lung. Although neutrophils are the dominant white blood cell in alveoli and bronchioles during acute infection (day 2-14)..
  23. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..cachexia;and 3) Characterize the effects of ghrelin in a tumor model of cachexia induced by the Lewis lung carcinoma (LLC) cell line...
  24. Samantha M Yeligar; Fiscal Year: 2014
    ..from well-established investigators, the abundant scientific opportunities within the Emory University Alcohol and Lung Biology Center, and a hypothesis-driven application exploring novel mechanisms of an important and clinically ..
  25. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..Macrophages are the primary defense cells in the lung responsible for uptake, degradation and clearance of foreign particles, all biophysical processes which rely upon ..
  26. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    b>Lung cancer is the number one cancer killer in the United States, exceeding breast, colorectal, prostate, and melanoma malignancies combined...
  27. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..patients to obliterative bronchiolitis(OB), the fibroproliferative process responsible for rejection of >50% of lung transplants...
  28. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..SOD isoform in the vasculature under normal conditions, and EC-SOD expression is decreased in animal models of lung or vascular injury and several human diseases, including one study showing a decrease in EC-SOD protein in the ..
  29. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..observed in other rodent redox models, including myocardial ischemia/reperfusion injury and chlorine inhalational lung injury...
  30. Junxuan Lu; Fiscal Year: 2014
    ..Sung-Hoon Kim, PGG possesses potent anti-angiogenic activities and exerts a strong anti- tumor effect in a mouse lung cancer model...
  31. Paul J Shami; Fiscal Year: 2014
    ..against acute myeloid leukemia, prostate cancer, hepatocellular carcinoma, multiple myeloma and non-small cell lung cancer...
  32. Maria Diakonova; Fiscal Year: 2014
    ..the involvement of PRL in breast cancer, the leading type of cancer in women and the second leading cause (after lung cancer) of cancer death among women. In 2008, 40,480 women are expected to die from breast cancer in the U.S...
  33. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells...
  34. Shervin Assassi; Fiscal Year: 2014
    ..mentored his Master's Thesis project, investigating the clinical predictors for progression of interstitial lung disease (ILD) in SSc. The results of this large prospective study have been recently published...
  35. CYNTHIA T MCEVOY; Fiscal Year: 2016
    ..alter the fetal origins of respiratory disease by blocking some of the effects of in-utero smoke exposure on lung development...
  36. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..short- and long-term pathological consequences of IR in other radiosensitive tissues, including liver, kidney and lung. The frequency and severity of fibrosis and cancer development will be assessed in a mouse model...
  37. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..perinatal mortality from abnormal intestinal and pancreatic function, altered glucose and lipid metabolism, and lung infections...
  38. Jian Li; Fiscal Year: 2016
    ..Neutropenic mouse thigh and lung infection models will be employed to evaluate the in vivo efficacy of the advanced leads...
  39. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..regeneration approach so it can be used in the future to develop tissue and organs of greater complexity such as lung and cardiac tissue...
  40. Melissa A Rosenkranz; Fiscal Year: 2014
    ..influences the inflammatory response in asthma (2) quantify the impact of chronic stress on objective measures of lung function and inflammation and (3) evaluate the impact of neural changes, accrued through training in mindfulness, ..
  41. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..Our research has implicated TLR4 as a mediator of lung edema and inflammation due to lung IRI...
  42. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..muscle-specific Cre recombinase mice, to elicit RoGFP expression in pulmonary artery smooth muscle cells in the lung. Using that model system to demonstrate efficacy, we will measure redox changes in smooth muscle cells in the ..
  43. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..Aberrant mucus accumulation due to mucin overproduction is one of major clinical symptoms associated with various lung diseases, such as asthma, cystic fibrosis, bronchitis, chronic obstructive pulmonary diseases, etc...
  44. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..obliterans Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  45. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..developing a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX)...
  46. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Postmortem studies of DV-infected patients and the AG129 mouse model demonstrate that ECs in the liver, lung, and spleen are infected...
  47. JoAnn Sekiguchi; Fiscal Year: 2014
    ..ataxia, immunodeficiency, cancer predisposition, recurrent sinopulmonary infections and chronic interstitial lung disease. The prognosis for this childhood disease is poor, and most patients do not survive beyond their teens...
  48. Alvaro Puga; Fiscal Year: 2015
    ..of the promoter of the tumor suppressor p16ink4a gene has been found in chromium-exposed workers who developed lung cancer, although p16ink4a promoter methylation accounts for only one third of cancer in this population, suggesting ..
  49. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..have been reported in patients with sporadic malignancies of plasma cells, leukemia, head and neck cancer, lung cancer, and ovarian cancer...
  50. Mary K Sheats; Fiscal Year: 2016
    ..animal models of inflammation: tail-wounding in zebrafish and TNFa induced cremaster injury and LPS-mediated acute lung injury in mice...
  51. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..6-2.9 times greater risk for heart disease, cancer, chronic lung disease, stroke and diabetes (1), finding effective interventions has profound public health implications...
  52. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..Translational Studies 15 , Challenge Topic 04-HL-102 to Develop Integrated Strategies to Elucidate Mechanisms of Lung Disease Summary/Abstract Project Synopsis: This Challenge Research project will undertake 1) a mouse genome-wide ..
  53. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are characterized by a rapid and severe respiratory failure, arising after clinical events including major surgery, trauma, ..
  54. Farrah Kheradmand; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cigarette smoke-related lung diseases is one of the most common causes of disability and death among veterans...
  55. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..transmitted diseases;hepatitis B;cardiovascular diseases;and cervical, breast, colorectal, liver, and lung cancer), and 4) incorporation of infrastructure service expenses in collaborative proposal budgets and commitment ..
  56. Brian F Volkman; Fiscal Year: 2016
    ..Over 20 cancer types express CXCR4 and metastasize to tissues that secrete SDF1, including bone marrow, lung, liver and lymph nodes...
  57. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Acquired abnormalities of FA genes and FA gene expression have been reported in patients with sporadic malignancies of plasma cells, leukemia, head and neck cancer, lung cancer, and ovarian cancer.
  58. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..Current cumulative totals of diagnosed cases through 2005 include approximately 2,800 lung, 2,000 prostate, 700 colorectal, 500 bladder, 300-400 each for stomach, pancreas, and kidney cancers, 300 head and ..
  59. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..prematurity that triggers an endogenous cytoprotective defense and thereby blocks pulmonary inflammation and acute lung injury (ALI)...
  60. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Finally, it is expected that these studies will reveal additional potential benefits of n-3 PUFA consumption on silica-induced lung disease and fibrosis, another understudied area.
  61. PEGGY SUE LAI; Fiscal Year: 2016
    ..provided by applicant): Research Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory lung diseases that affect an estimated 35 million Americans...
  62. Clifford A Lowell; Fiscal Year: 2016
    ..me/me) or motheaten viable (mev/mev)) develop dramatic autoimmunity, inflammation and early mortality due to lung inflammation (~4 weeks for complete SHP-1 loss in me/me mice and ~8-10 weeks in the hypomorphic mev/mev mice)...
  63. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..Abnormal lung cell proliferation and apoptosis, as well as extracellular matrix degradation, can alter lung cell homeostasis and ..
  64. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..Detecting pre-malignant lesions in central airway in high risk population has significant implication in decreasing lung cancer morbidity and mortality...
  65. MECHANISM OF TRH EFFECTS IN FETAL LUNG DEVELOPMENT
    UDAY DEVASKAR; Fiscal Year: 1999
    ..Maternal Thyrotropin Releasing Hormone (TRH) treatment enhances fetal lung maturation, but inhibits antioxidant enzyme (AOE)...
  66. Molecular Epidemiology of Secondary Lung Cancer
    Peter Shields; Fiscal Year: 2007
    Several studies indicate that women with breast cancer who undergo radiotherapy are susceptible to secondary lung cancer, whether they are smokers or nonsmokers...
  67. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Background: Primary carcinoma of the lung is the leading cause of cancer death in the United States. A test that detects early-stage disease could potentially reduce the number of deaths...
  68. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    ..b>Lung transplantation (LTX) has extended and improved the lives of thousands of patients with end-stage lung disease, but ..
  69. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lung transplantation is a life-saving option for selected patients with end-stage lung disease...
  70. FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung Cance
    Feng Ming Kong; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer deaths in the United States, of which 80% are non-small cell lung cancer (NSCLC)...
  71. Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    Chantal Darquenne; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Detailed knowledge of the fate of aerosols in the lung is essential in understanding the effect of exposure to airborne particulate matter (PM) and infectious agents as well as in assessing the ..
  72. Clinical Trial of DRibble Vaccine in NSCLC
    Walter Urba; Fiscal Year: 2009
    More than 90% of advanced lung cancer patients will die within a year or two of diagnosis. Lung cancer will kill 160,000 Americans this year...
  73. National Lung Screening Trial (NLST)
    Cheryl Robinson; Fiscal Year: 2009
    The National Lung Screening Trial (NLST), launched in September 2002, continues to be a critically important component of the NCI goal to eliminate death and suffering from lung cancer...