vocal cords

Summary

Summary: The folds of mucous membrane along either wall of the larynx from the angle between the laminae of the thyroid cartilage to the vocal process of the arytenoid cartilage.

Top Publications

  1. ncbi Gene expression of transforming growth factor-beta1 and hepatocyte growth factor during wound healing of injured rat vocal fold
    Tsunehisa Ohno
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, Tennessee 37232 4480, USA
    Laryngoscope 119:806-10. 2009
  2. ncbi Estimation of vocal dysperiodicities in disordered connected speech by means of distant-sample bidirectional linear predictive analysis
    Frédéric Bettens
    Department Signals and Waves, Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    J Acoust Soc Am 117:328-37. 2005
  3. pmc Morphological and extracellular matrix changes following vocal fold injury in mice
    Masaru Yamashita
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 192:262-71. 2010
  4. ncbi Immediate inflammatory response and scar formation in wounded vocal folds
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 115:921-9. 2006
  5. ncbi Viscoelastic and histologic properties in scarred rabbit vocal folds after mesenchymal stem cell injection
    S Hertegard
    Department of Logopedics and Phoniatrics, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Laryngoscope 116:1248-54. 2006
  6. pmc Characterization of mesenchymal stem cells from human vocal fold fibroblasts
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
    Laryngoscope 120:546-51. 2010
  7. ncbi Refinements in modeling the passive properties of laryngeal soft tissue
    Eric J Hunter
    National Center for Voice and Speech, The Denver Center for the Performing Arts, Denver, CO 80204, USA
    J Appl Physiol (1985) 103:206-19. 2007
  8. ncbi Comparison of biomechanical modeling of register transitions and voice instabilities with excised larynx experiments
    Isao T Tokuda
    School of Information Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
    J Acoust Soc Am 122:519-31. 2007
  9. ncbi The role of vocal tract filtering in identity cueing in rhesus monkey (Macaca mulatta) vocalizations
    D Rendall
    Department of Anthropology, University of California at Davis 95616, USA
    J Acoust Soc Am 103:602-14. 1998
  10. pmc The interaction of glottal-pulse rate and vocal-tract length in judgements of speaker size, sex, and age
    David R R Smith
    Centre for Neural Basis of Hearing, Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    J Acoust Soc Am 118:3177-86. 2005

Research Grants

  1. Laser photothermolysis of scar in vocal cords
    Elie Rebeiz; Fiscal Year: 2002
  2. Pathophysiology of Spasmodic Dysphonia: a TMS study
    Teresa Jacobson Kimberley; Fiscal Year: 2013
  3. Dynamic Vocal Fold Abduction for Bilateral Paralysis
    Michael Broniatowski; Fiscal Year: 2006
  4. Voice-preserving Treatment of Larynegeal Papilloma
    Zhi Wang; Fiscal Year: 2006
  5. AN ECM SCAFFOLD FOR HEAD AND NECK REPAIR
    Alan Spievack; Fiscal Year: 2000
  6. Voice-preserved therapy of laryngeal papilloma in children
    Zhi Wang; Fiscal Year: 2009
  7. BASEMENT MEMBRANE ZONE IN VOCAL INJURY
    Steven Gray; Fiscal Year: 1993
  8. Laser Atraumatic Treatment of Ectasias on Vocal Cords
    Zhi Wang; Fiscal Year: 2006
  9. DEVELOPMENT OF A LARYNGEAL PACER
    Ira Sanders; Fiscal Year: 1992
  10. Quantitative Modeling of Speech
    Brad H Story; Fiscal Year: 2010

Detail Information

Publications315 found, 100 shown here

  1. ncbi Gene expression of transforming growth factor-beta1 and hepatocyte growth factor during wound healing of injured rat vocal fold
    Tsunehisa Ohno
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, Tennessee 37232 4480, USA
    Laryngoscope 119:806-10. 2009
    ....
  2. ncbi Estimation of vocal dysperiodicities in disordered connected speech by means of distant-sample bidirectional linear predictive analysis
    Frédéric Bettens
    Department Signals and Waves, Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    J Acoust Soc Am 117:328-37. 2005
    ....
  3. pmc Morphological and extracellular matrix changes following vocal fold injury in mice
    Masaru Yamashita
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Cells Tissues Organs 192:262-71. 2010
    ..Morphological and ECM changes following vocal fold injury in the mouse were generally consistent with those reported in other animal models, particularly the rat, although wound repair in the mouse appears to occur at a faster rate...
  4. ncbi Immediate inflammatory response and scar formation in wounded vocal folds
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, USA
    Ann Otol Rhinol Laryngol 115:921-9. 2006
    ..Thus, we examined the inflammation profile and extracellular matrix production in wounded vocal folds in the acute phase of wound healing...
  5. ncbi Viscoelastic and histologic properties in scarred rabbit vocal folds after mesenchymal stem cell injection
    S Hertegard
    Department of Logopedics and Phoniatrics, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Laryngoscope 116:1248-54. 2006
    ..Because MSCs are antiinflammatory and regenerate mesenchymal tissues, can MSC injection reduce vocal fold scarring after injury?..
  6. pmc Characterization of mesenchymal stem cells from human vocal fold fibroblasts
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
    Laryngoscope 120:546-51. 2010
    ..We hypothesized that human vocal fold fibroblasts (hVFF) isolated from the lamina propria meet the criteria established to define MSCs and are functionally similar to MSCs derived from BM and adipose tissue...
  7. ncbi Refinements in modeling the passive properties of laryngeal soft tissue
    Eric J Hunter
    National Center for Voice and Speech, The Denver Center for the Performing Arts, Denver, CO 80204, USA
    J Appl Physiol (1985) 103:206-19. 2007
    ..ncvs.org/ncvs/library/tech) in which comprehensive muscle data and sensitivity analysis, as well as downloadable data files and computer scripts, are made available...
  8. ncbi Comparison of biomechanical modeling of register transitions and voice instabilities with excised larynx experiments
    Isao T Tokuda
    School of Information Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
    J Acoust Soc Am 122:519-31. 2007
    ..It is concluded that the abrupt changes between chest and falsetto registers can be understood as shifts in dominance of eigenmodes of the vocal folds...
  9. ncbi The role of vocal tract filtering in identity cueing in rhesus monkey (Macaca mulatta) vocalizations
    D Rendall
    Department of Anthropology, University of California at Davis 95616, USA
    J Acoust Soc Am 103:602-14. 1998
    ..Implications of these findings for vocal production mechanisms in nonhuman primates and previous studies of rhesus monkey vocalizations are discussed...
  10. pmc The interaction of glottal-pulse rate and vocal-tract length in judgements of speaker size, sex, and age
    David R R Smith
    Centre for Neural Basis of Hearing, Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    J Acoust Soc Am 118:3177-86. 2005
    ..For vowels with abnormal combinations of low GPRs and short VTLs, the VTL information appears to decide the sex/age judgement...
  11. ncbi Effects of growth factors on extracellular matrix production by vocal fold fibroblasts in 3-dimensional culture
    Ying Luo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 12:3365-74. 2006
    ..The results also suggest that multiple growth factors might be employed sequentially or in combination to program the makeup of cell-hydrogel constructs for vocal fold tissue repair...
  12. ncbi Long-term results in patients after combined laser total arytenoidectomy with posterior cordectomy for bilateral vocal cord paralysis
    Maciej Misiolek
    ENT Department, Silesian Medical University, Sklodowskiej Curie 10, 41 800, Zabrze, Poland
    Eur Arch Otorhinolaryngol 264:895-900. 2007
    ..In general, it can be concluded that laser arytenoidectomy with posterior cordectomy is a durable and effective procedure, although the objective assessment does not fully match the patient's subjective impression...
  13. ncbi Interstitial protein alterations in rabbit vocal fold with scar
    Susan L Thibeault
    Division of Otolaryngology, Head and Neck Surgery, Department of Communicative Disorders, University of Utah, Salt Lake City 84132, USA
    J Voice 17:377-83. 2003
    ..The implications of altered interstitial proteins levels and their affect on the fibrous proteins will be discussed in relation to increased vocal fold stiffness and viscosity, which characterizes vocal fold scar...
  14. ncbi Histologic characterization of rat vocal fold scarring
    Tomoko Tateya
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 114:183-91. 2005
    ..Fibronectin increased for 4 weeks and then decreased; it was close to the control level at 8 and 12 weeks. These results suggest that the tissue remodeling process in scarred vocal folds slows down around 2 months after wounding...
  15. ncbi Biochemical markers associated with acute vocal fold wound healing: a rabbit model
    Ryan C Branski
    Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA, USA
    J Voice 19:283-9. 2005
    ....
  16. ncbi Histological study of acute vocal fold injury in a rat model
    Tomoko Tateya
    Division of Otolaryngology Head and Neck Surgery, Dept of Surgery, University of Wisconsin Madison, K4 789 CSC 600 Highland Ave, Madison, WI 53792 USA
    Ann Otol Rhinol Laryngol 115:285-92. 2006
    ..We used an acute vocal fold injury in a rat model to characterize vocal fold wound healing by studying the expression pattern of the extracellular matrix components in the vocal fold lamina propria...
  17. ncbi Characterization of vocal fold scarring in a canine model
    Bernard Rousseau
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Laryngoscope 113:620-7. 2003
    ..The objective was to assess the histological and viscoelastic shear tissue properties of the scarred vocal fold lamina propria at 2 and 6 months postoperatively in a canine model...
  18. ncbi Aggressive elimination of precancerous lesions of the vocal cords to avoid risk of cancer
    Max Rohde
    Department of ENT Head and Neck Surgery, Odense University Hospital, Odense, Denmark
    Dan Med J 59:A4399. 2012
    Several studies show that early histological classification and excision of precancerous lesions of the vocal cords reduces the risk of cancer development. National Danish guidelines have not been established...
  19. ncbi Laryngeal reinnervation for bilateral vocal fold paralysis
    Mat B Marina
    Royal National Throat Nose and Ear Hospital, University College London, London, UK
    Curr Opin Otolaryngol Head Neck Surg 19:434-8. 2011
    ..On the other hand, the procedure is not simple. This review explores the recent literature on surgical technique and factors that may contribute to the success...
  20. pmc Laryngeal reinnervation using ansa cervicalis for thyroid surgery-related unilateral vocal fold paralysis: a long-term outcome analysis of 237 cases
    Wei Wang
    Department of Otorhinolaryngology Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
    PLoS ONE 6:e19128. 2011
    ..To evaluate the long-term efficacy of delayed laryngeal reinnervation using the main branch of the ansa cervicalis in treatment of unilateral vocal fold paralysis (UVFP) caused by thyroid surgery...
  21. ncbi Modulation of myosin heavy chains in rat laryngeal muscle
    A Shiotani
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21203-6402, USA
    Laryngoscope 111:472-7. 2001
    ..The expression of normal MHC composition is dependent on the condition of appropriate neural contact and functional reinnervation...
  22. ncbi Narrow band imaging in the diagnosis of intra-epithelial and invasive laryngeal squamous cell carcinoma: a preliminary report of two cases
    Takashi Masaki
    Department of Otorhinolaryngology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Japan
    Auris Nasus Larynx 36:712-6. 2009
    ..Based on our results, the vascular neoplastic changes of carcinoma in situ of the larynx could be similar to carcinoma in situ of the esophagus...
  23. ncbi Fibronectin: an interesting vocal fold protein
    Scot D Hirschi
    University of Utah Medical School, Salt Lake City 84123, USA
    J Voice 16:310-6. 2002
    ..Lastly, it discusses preliminary microarray data that show gene expression for fibronectin to be upregulated in true vocal folds when compared to false vocal folds...
  24. ncbi [Study on vibration mode of different phonatory source and compensation after partial laryngectomy]
    W Xu
    Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 36:454-7. 2001
    ..To investigate the nature of pathological voice production and compensatory mechanism after partial laryngectomy...
  25. ncbi The effect of vocal hygiene education for patients with vocal polyp
    Young Sun Yun
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam Gu, Seoul, Korea
    Otolaryngol Head Neck Surg 137:569-75. 2007
    ..The authors aimed to assess the effect of vocal hygiene education for patients suffering with vocal polyp and to discover the meaningful factors that can predict better outcomes with performing vocal hygiene...
  26. ncbi Oral breathing increases Pth and vocal effort by superficial drying of vocal fold mucosa
    Mahalakshmi Sivasankar
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA
    J Voice 16:172-81. 2002
    ..The facilitatory role of superficial hydration on vocal fold oscillation should be considered in biomechanical models of phonation and in the clinical prevention of laryngeal dryness...
  27. ncbi The importance of hyaluronic acid in vocal fold biomechanics
    R W Chan
    Department of Audiology and Speech Sciences, Purdue University, 1353 Heavilon Hall, West Lafayette, IN 47907 1353, USA
    Otolaryngol Head Neck Surg 124:607-14. 2001
    ..This study examined the influence of hyaluronic acid (HA) on the biomechanical properties of the human vocal fold cover (the superficial layer of the lamina propria)...
  28. ncbi Regulation of vocal fold transepithelial water fluxes
    K V Fisher
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA
    J Appl Physiol (1985) 91:1401-11. 2001
    ..05). The presence of the Na(+)-K(+)-ATPase in the vocal fold epithelium and the electrolyte transport derived from its activity provide the intrinsic mechanisms to regulate cell volume as well as vocal fold hydration...
  29. ncbi Utility of voice therapy in the management of vocal fold polyps and cysts
    Seth M Cohen
    Duke Voice Care Center, Division of Otolaryngology Head and Neck Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Otolaryngol Head Neck Surg 136:742-6. 2007
    ..To evaluate the efficacy of voice therapy in the management of vocal fold polyps and cysts...
  30. ncbi Office-based optical coherence tomographic imaging of human vocal cords
    Shuguang Guo
    University of California, Irvine, Department of Biomedical Engineering and Beckman Laser Institute, 92697, USA
    J Biomed Opt 11:30501. 2006
    ..Office-based OCT has the potential to guide surgical biopsies, direct therapy, and monitor disease. This is a promising imaging modality to study the larynx...
  31. ncbi [The reconstruction of laryngeal function in subtotal laryngectomy by pedicled flaps]
    F Yu
    Department of Otorhinolaryngology, Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 36:213-5. 2001
    ..To explore the possibility of subtotal laryngectomy in the treatment of advanced laryngeal cancer and selection of reconstruction...
  32. pmc Hypertonic challenge to porcine vocal folds: effects on epithelial barrier function
    Mahalakshmi Sivasankar
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA
    Otolaryngol Head Neck Surg 142:79-84. 2010
    ..We examined the effects of hypertonic surface fluid on vocal fold epithelial resistance, paracellular pathway morphology, and tight junction protein integrity...
  33. ncbi Multiparametric analysis of vocal fold vibrations in healthy and disordered voices in high-speed imaging
    Elisabeth C Inwald
    Department of Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Bohlenplatz, Erlangen, Germany
    J Voice 25:576-90. 2011
    ....
  34. ncbi Long-term functional outcome after unilateral cordectomy
    Annerose Keilmann
    Department for ENT and Communication Disorders, Mainz University Medical Center, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 73:38-46. 2011
    ..Our aim was to longitudinally analyze the vocal outcome after endoscopic CO(2) laser resection of early glottic carcinoma...
  35. ncbi Acoustic voice analysis by means of the hoarseness diagram
    M Frohlich
    Drittes Physikalisches Institut, Georg August Universitat, Gottingen, Germany
    J Speech Lang Hear Res 43:706-20. 2000
    ..The tests themselves demonstrate several application possibilities, including the quantitative monitoring of individual voices...
  36. ncbi Long-term outcomes of injection laryngoplasty in patients with potentially recoverable vocal fold paralysis
    Lindsey C Arviso
    Emory Voice Center, Atlanta, Georgia, USA
    Laryngoscope 120:2237-40. 2010
    ..This study investigates the long-term outcomes of subjects treated with an IL...
  37. ncbi Effects of transforming growth factor-beta1 on human vocal fold fibroblasts
    Ryan C Branski
    Department of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Otol Rhinol Laryngol 118:218-26. 2009
    ..We studied the effect of transforming growth factor (TGF)-beta on immortalized human vocal fold fibroblasts...
  38. ncbi Clinical experience with collagen injection of the vocal fold: a study of 155 patients
    Miwako Kimura
    Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Auris Nasus Larynx 35:67-75. 2008
    ..This study evaluated the results of laryngeal collagen injection...
  39. ncbi Histological behavior of the vocal fold after hyaluronic acid injection
    Paulo Sérgio Lins Perazzo
    Department of Otolaringology, Santa Casa de Sao Paulo, Faculty of Medical Sciences, Sao Paulo, Brazil
    J Voice 23:95-8. 2009
    ..Tissue necrosis and foreign body inflammatory reaction were not observed in either group. The current study suggests that HA is a good alternative for a filling material of the vocal folds when treating glottal insufficiency...
  40. pmc Raised intensity phonation compromises vocal fold epithelial barrier integrity
    Bernard Rousseau
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, Tennessee 37232 4480, USA
    Laryngoscope 121:346-51. 2011
    ..We investigated the hypothesis that 30 minutes of raised intensity phonation alters transcript levels of vocal fold intercellular tight junction proteins and disrupts the vocal fold epithelial barrier...
  41. pmc Novel isolation and biochemical characterization of immortalized fibroblasts for tissue engineering vocal fold lamina propria
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Tissue Eng Part C Methods 15:201-12. 2009
    ..This is the first report of immortalization and biochemical characterization of hVFFs, providing a novel and invaluable tool for tissue regeneration applications in the larynx...
  42. ncbi Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model
    Shigeru Hirano
    Department of Bronchoesophagology, Kyoto National Hospital, Kyoto, Japan
    Laryngoscope 114:548-56. 2004
    ..The present study aimed to demonstrate the effects of HGF on vocal fold scarring in an in vivo rabbit model...
  43. ncbi Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor: a canine study
    Atsushi Suehiro
    Department of Otolaryngology Head and Neck Surgery, Kyoto University, Japan
    Acta Otolaryngol 130:844-50. 2010
    ..Results of the current study revealed improved phonation threshold pressure (PTP), normalized mucosal wave amplitude (NMWA), and less contraction of the lamina propria in injured larynges treated with basic fibroblast growth factor (bFGF)...
  44. ncbi Model-based classification of nonstationary vocal fold vibrations
    Tobias Wurzbacher
    Department of Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Medical School, Erlangen, Germany
    J Acoust Soc Am 120:1012-27. 2006
    ..The nonstationary vocal fold vibrations contain additional information about vocal fold irregularities, which are needed for an objective interpretation and classification of voice disorders...
  45. ncbi Phonomicrosurgery in singers and performing artists: treatment outcomes, management theories, and future directions
    Steven M Zeitels
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Ann Otol Rhinol Laryngol Suppl 190:21-40. 2002
    ....
  46. ncbi [Functional results of treatment of early carcinoma in the glottic region of the larynx]
    J P Milovanović
    Klinika za ORL i maksilofacijalnu hirurgiju KCS, Beograd
    Acta Chir Iugosl 56:95-100. 2009
    ..From a functional point of view these two methods are superior to open surgery chordectomy...
  47. ncbi Factors associated with voice therapy outcomes in the treatment of presbyphonia
    Ted Mau
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Laryngoscope 120:1181-7. 2010
    ..Age, vocal fold atrophy, glottic closure pattern, and the burden of medical problems are associated with voice therapy outcomes for presbyphonia...
  48. ncbi Laryngoplasty with hyaluronic acid in patients with unilateral vocal fold paralysis
    Rudolf Reiter
    Department of Otolaryngology Head and Neck Surgery, Section of Phoniatrics and Pedaudiology, University of Ulm, Ulm, Germany
    J Voice 26:785-91. 2012
    ..Analysis of the optimal glottic width, effectiveness (long-term voice improvement as a consequence of longevity of Restylane), and safety of this new method was made...
  49. ncbi Functional analysis of voice using simultaneous high-speed imaging and acoustic recordings
    Yuling Yan
    Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Voice 21:604-16. 2007
    ..The results of these analyses show that a combined imaging/acoustic analysis approach provides better characterization of the vibratory behavior of the vocal folds as it correlates with vocal output and pathology...
  50. pmc Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts
    Hang Zhou
    Department of Otolaryngology, New York University School of Medicine, New York, New York 10016, USA
    Laryngoscope 121:1261-5. 2011
    ..In addition, we describe a novel organotypic model, a critical step in the development of therapeutic trials...
  51. ncbi Radiophonosurgery of benign superficial vocal fold lesions
    Sameh M Ragab
    Department of Otolaryngology and Head and Neck Surgery, Tanta Faculty of Medicine and University Hospitals, Egypt
    J Laryngol Otol 119:961-6. 2005
    ..To conduct a prospective randomized controlled trial describing and investigating the efficacy and safety of radiosurgical excision of benign superficial vocal fold lesions...
  52. pmc A method for identification of vocal fold lamina propria fibroblasts in culture
    Susan L Thibeault
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, WI, USA
    Otolaryngol Head Neck Surg 139:816-22. 2008
    ..We present an in vitro technique that allows for identification of fibroblasts by ruling out the possibility of the cells belonging to other lineages that are found in vocal fold tissue...
  53. ncbi [The videostrobokymography in phoniatric practice]
    Agata Szkiełkowska
    Instytut Fizjologii i Patologii Słuchu, Warszawa
    Otolaryngol Pol 66:214-8. 2012
    ..Thanks to videostrobokymography the vocal fold vibration from particular area of glottal chink, can be assessed in an objective way...
  54. ncbi Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblasts
    Xinhong Lim
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann Otol Rhinol Laryngol 117:227-38. 2008
    ..To evaluate previously established in vivo cytokine and ECM gene expression hypotheses, we examined in vitro vocal fold fibroblast responses to exogenous inflammatory factor stimulation...
  55. ncbi Modified frontolateral partial laryngectomy without tracheotomy
    Pin Dong
    Department of Otolaryngology Head and Neck Surgery, Shanghai First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Otolaryngol Head Neck Surg 141:70-4. 2009
    ..To investigate the feasibility of modified frontolateral partial laryngectomy without tracheotomy for patients with early-stage laryngeal cancer or dysplasia of the true vocal cord...
  56. pmc Cell viability viscoelastic measurement in a rheometer used to stress and engineer tissues at low sonic frequencies
    Sarah A Klemuk
    National Center for Voice and Speech at the Department of Communication Sciences and Disorders, The University of Iowa, Iowa City, Iowa 52242, USA
    J Acoust Soc Am 124:2330-9. 2008
    ..Resulting strain was quantified throughout the test period. Rheologic data and cell viability are reported for each condition, and future improvements are discussed...
  57. ncbi Management of benign vocal fold lesions: a survey of current opinion and practice
    Lucian Sulica
    The Center for the Voice, Department of Otolaryngology, The New York Eye and Ear Infirmary, New York, New York, USA
    Ann Otol Rhinol Laryngol 112:827-33. 2003
    ..Therefore, traditional diagnostic categories do not seem to be useful guides to treatment, and may need to be reevaluated in light of improvements in diagnostic technology and surgical technique...
  58. ncbi Histologic assessment of epithelial thickness in early laryngeal cancer or precursor lesions and its impact on endoscopic imaging
    Christoph Arens
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Giessen and Marburg, Feulgenstrasse 10, 35385, Giessen, Germany
    Eur Arch Otorhinolaryngol 264:645-9. 2007
    ..In most cases laryngeal epithelium demonstrates progressive thickening during cancer genesis leading to a loss of autofluorescence...
  59. ncbi Geometry of human vocal folds and glottal channel for mathematical and biomechanical modeling of voice production
    Petr Sidlof
    Institute of Thermomechanics, Academy of Sciences of the Czech Republic, Dolejskova 5, 182 00 Prague 8, Czech Republic
    J Biomech 41:985-95. 2008
    ..Left-right differences between the cross-sectional shapes of the vocal folds were found in both the larynges...
  60. ncbi Automatic diagnosis of vocal fold paresis by employing phonovibrogram features and machine learning methods
    Daniel Voigt
    Department of Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Bohlenplatz 21, D 91054 Erlangen, Germany
    Comput Methods Programs Biomed 99:275-88. 2010
    ..The automatic Phonovibrogram analysis approach exceeded the experienced raters' classifications by 9%. The presented method holds a lot of potential for providing reliable vocal fold diagnosis support in the future...
  61. pmc Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models
    Diane M Bless
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Curr Opin Otolaryngol Head Neck Surg 18:481-6. 2010
    ....
  62. pmc Role of tumor necrosis factor-alpha in wound repair in human vocal fold fibroblasts
    Xia Chen
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Laryngoscope 120:1819-25. 2010
    ....
  63. ncbi Impairment of voice quality in paradoxical vocal fold motion dysfunction
    Kursat Yelken
    Department of Otolaryngology, Gaziomanpasa University, Tokat, Turkey
    J Voice 24:724-7. 2010
    ..To compare subjective and objective voice-quality parameters between asymptomatic paradoxical vocal fold motion dysfunction (PVFMD) patients and healthy individuals...
  64. ncbi Hepatocyte growth factor and its receptor c-met in rat and rabbit vocal folds
    Shigeru Hirano
    Department of Surgery, University of Wisconsin Madison, 53792, USA
    Ann Otol Rhinol Laryngol 111:661-6. 2002
    ..The implication of these findings is that HGF is involved in wound healing of the vocal fold, and may provide an alternative approach in preventing and treating vocal fold scarring...
  65. ncbi Vocal folds detect ionic perturbations on the luminal surface: an in vitro investigation
    Mahalakshmi Sivasankar
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Voice 22:408-19. 2008
    ..05). Viable ovine vocal fold epithelia detect ionic perturbations to the luminal surface. This sensitivity to luminal ionic challenge may be necessary to maintain the homeostasis of surface fluid...
  66. ncbi A numerical analysis of phonation using a two-dimensional flexible channel model of the vocal folds
    T Ikeda
    Department of Aerospace Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Japan
    J Biomech Eng 123:571-9. 2001
    ..The numerical results show that the collision plays an important role in speech sound, especially for higher resonant frequency components, because it causes the source sound to include high-frequency components...
  67. ncbi Ansa cervicalis-to-recurrent laryngeal nerve anastomosis for unilateral vocal fold paralysis: experience of a single institution
    Robert R Lorenz
    Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Ann Otol Rhinol Laryngol 117:40-5. 2008
    ..We present all patients who have undergone ansa-RLN anastomosis for UVFP at our institution...
  68. ncbi Unsteady behavior of flow in a scaled-up vocal folds model
    MICHAEL KRANE
    Center for Advanced Information Processing, Rutgers University, Piscataway, New Jersey 08854, USA
    J Acoust Soc Am 122:3659-70. 2007
    ..Vortex shedding appears to be a factor both in controlling flow resistance and in cycle-to-cycle volume flow variations. All these observations strongly suggest that glottal flow is inherently unsteady...
  69. ncbi Results of ansa to recurrent laryngeal nerve reinnervation
    Walter T Lee
    Department of Otolaryngology, Head and Neck Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Otolaryngol Head Neck Surg 136:450-4. 2007
    ..We sought to describe the results of ansa cervicalis to recurrent laryngeal nerve (ansa-RLN) reinnervation for unilateral vocal fold paralysis...
  70. ncbi Numerical analysis of effects of transglottal pressure change on fundamental frequency of phonation
    Shinji Deguchi
    Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    Ann Otol Rhinol Laryngol 116:128-34. 2007
    ..In humans, a decrease in transglottal pressure (Pt) causes an increase in the fundamental frequency of phonation (F0) only at a specific voice pitch within the modal register, the mechanism of which remains unclear...
  71. ncbi Stroboscopy as a research instrument: development of a perceptual evaluation tool
    Clark A Rosen
    Department of Otolaryngology, The Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
    Laryngoscope 115:423-8. 2005
    ..Future research using this instrument will most likely increase the reliability and utility of the instrument with the use of prestudy reviewer training and/or the use of video examples to serve as anchors or external references...
  72. ncbi Theoretical assessment of unsteady aerodynamic effects in phonation
    Michael H Krane
    Center for Advanced Information Processing, Rutgers University, Piscataway, New Jersey 08854, USA
    J Acoust Soc Am 120:1578-88. 2006
    ..The analysis suggests that glottal flow may be considered quasisteady only insofar as traditional assumptions concerning glottal jet behavior can be confirmed...
  73. ncbi DNA microarray gene expression analysis of a vocal fold polyp and granuloma
    Susan L Thibeault
    Division of Otolaryngology Head and Neck Surgery, School of Medicine, University of Utah, Salt Lake City 84132 2301, USA
    J Speech Lang Hear Res 46:491-502. 2003
    ..Further investigation is needed on larger sample sizes to establish transcriptional gene expression patterns for VP and VG...
  74. pmc Onset and offset phonation threshold flow in excised canine larynges
    Michael F Regner
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Laryngoscope 118:1313-7. 2008
    ..We also explored the hypothesis that the ratio of these two (PTF offset divided by PTF onset) falls within [0.707, 1.0]...
  75. pmc Mammalian laryngseal air sacs add variability to the vocal tract impedance: physical and computational modeling
    Tobias Riede
    Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi shi, Ishikawa 923 1292, Japan
    J Acoust Soc Am 124:634-47. 2008
    ..The experiments demonstrated that air-sac-like structures can destabilize the sound source. The results were validated by a transmission line computational model...
  76. ncbi A theoretical study of the hysteresis phenomenon at vocal fold oscillation onset-offset
    J C Lucero
    Departamento de Matematica, Universidade de Brasilia, Brazil
    J Acoust Soc Am 105:423-31. 1999
    ..5-1, in agreement with the experimental evidence. This value depends on the phase delay in motion of the upper edge of the vocal folds versus the lower edge, and on the particular model adopted for airflow separation within the glottis...
  77. ncbi Cellular physiology of the vocal folds
    S D Gray
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Otolaryngol Clin North Am 33:679-98. 2000
    ..Lastly, aspects of cellular health and cellular pathology are discussed...
  78. pmc A rat excised larynx model of vocal fold scar
    Nathan V Welham
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Speech Lang Hear Res 52:1008-20. 2009
    ..To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar...
  79. ncbi Effects of surgery on the phonation threshold pressure in patients with vocal fold polyps
    Tyng Guey Wang
    Department of Rehabilitation, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 109:62-8. 2010
    ..There are few objective measurements to assess the results of surgery for vocal fold polyps. This study investigated the effects of surgery on the phonation threshold pressure (PTP) in patients with vocal fold polyps...
  80. pmc Influence of flow separation location on phonation onset
    Zhaoyan Zhang
    UCLA School of Medicine, 31 24 Rehabilitation Center, 1000 Veteran Avenue, Los Angeles, California 90095 1794, USA
    J Acoust Soc Am 124:1689-94. 2008
    ..However, in contrast to previous theoretical analyses, this study showed that phonation was facilitated, rather than prohibited, by the upstream movement of the flow separation point within a divergent glottis...
  81. ncbi Cell production in injured vocal folds: a rat study
    Ichiro Tateya
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, K4 789 CSC, 600 Highland Ave, Madison, WI 53792, USA
    Ann Otol Rhinol Laryngol 115:135-43. 2006
    ..To reveal the characteristics of vocal fold cell production, we investigated cell proliferation in the acute phase of wound healing...
  82. ncbi Comparing phonation threshold flow and pressure by abducting excised larynges
    Daniel G Hottinger
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Laryngoscope 117:1695-9. 2007
    ..Goals were to examine phonation threshold flow as a measurable parameter sensitive to physiologic changes in the vocal folds and compare the relative sensitivities of phonation threshold flow and phonation threshold pressure...
  83. ncbi The influence of subglottal acoustics on laboratory models of phonation
    Zhaoyan Zhang
    UCLA School of Medicine, 31 24 Rehabilitation Center, 1000 Veteran Avenue, Los Angeles, California 90095 1794, USA
    J Acoust Soc Am 120:1558-69. 2006
    ..Recommendations are given for ruling out acoustical resonances as the source of nonlinear phenomena in future laboratory studies of phonation...
  84. ncbi Vocal fold epithelial response to luminal osmotic perturbation
    Mahalakshmi Sivasankar
    Department of Speech, Language, and Hearing Sciences, Heavilon Hall, 500 Oval Drive, Purdue University, West Lafayette, IN 47907, USA
    J Speech Lang Hear Res 50:886-98. 2007
    ..Bidirectional transepithelial water fluxes were measured in vocal folds exposed to physiologically realistic luminal osmotic perturbations in vitro...
  85. pmc Nonlinear source-filter coupling in phonation: vocal exercises
    Ingo Titze
    National Center for Voice and Speech, The Denver Center for the Performing Arts, Denver, Colorado, USA
    J Acoust Soc Am 123:1902-15. 2008
    ....
  86. pmc Phonation threshold flow measurements in normal and pathological phonation
    Peiyun Zhuang
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Laryngoscope 119:811-5. 2009
    ..Both polyps and nodules contribute to an increased PTF by creating an incomplete glottal closure and increased vocal fold mass and thickness...
  87. ncbi Narrow band imaging and high definition television in the assessment of laryngeal cancer: a prospective study on 279 patients
    Cesare Piazza
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
    Eur Arch Otorhinolaryngol 267:409-14. 2010
    ..NBI has also a role in the postoperative setting, due to its ability in early detection of persistences, recurrences, and metachronous tumors...
  88. pmc Regeneration of aged rat vocal folds using hepatocyte growth factor therapy
    Tsunehisa Ohno
    Department of Otolaryngology, Vanderbilt University Bill Wilkerson Center for Otolaryngology and Communication Sciences, Nashville, Tennessee 37232 4480, USA
    Laryngoscope 119:1424-30. 2009
    ....
  89. ncbi Direct measurement of onset and offset phonation threshold pressure in normal subjects
    Randall L Plant
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Acoust Soc Am 116:3640-6. 2004
    ..Two of the five subjects demonstrated a significant hysteresis effect, but one subject actually had higher offset pressures than onset pressures...
  90. ncbi The minimum glottal airflow to initiate vocal fold oscillation
    Jack J Jiang
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792 7375, USA
    J Acoust Soc Am 121:2873-81. 2007
    ..Also discussed is the potential significance of PTF in investigating the energy distribution in a vocal fold vibration system and related clinical applications...
  91. ncbi Real-time tracking of vocal fold injections with optical coherence tomography
    James A Burns
    Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Laryngoscope 119:2182-6. 2009
    ..Using OCT both to delineate the depth of subepithelial injections real-time and to serially image the implant over time would be valuable, and has not been demonstrated previously...
  92. ncbi Effects of voice therapy: a systematic review
    R Speyer
    Department of O R L and Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    J Voice 22:565-80. 2008
    ..Furthermore, the conclusions of most studies cannot be generalized easily or compared to one another. As a consequence, many issues in the field of effects of voice therapy have yet been unanswered...
  93. ncbi Radiotherapy for carcinoma in situ of the true vocal cords
    Allie Garcia-Serra
    Department of Radiation Oncology, University of Florida College of Medicine, PO Box 100385, Gainesville, Florida 32610 0385, USA
    Head Neck 24:390-4. 2002
    To report long-term rates of tumor control after radiotherapy (RT) for carcinoma in situ (CIS) of the true vocal cords (TVC)...
  94. pmc Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography
    James B Kobler
    Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Laryngoscope 120:1354-62. 2010
    ..If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation...
  95. ncbi A hystopathological study of thyroarytenoid muscle invasion in early (T1) glottic carcinoma
    Sinan Kocaturk
    Department of II Otorhinolaryngology Head and Neck Surgery, Social Security Organization, Ankara Education Hospital, Sivas, Turkey
    Otolaryngol Head Neck Surg 132:581-3. 2005
    ..Surgical specimens belonging to 16 patients who underwent partial laryngectomy for T1 glottic cancer were subjected to detailed histopathologic examination; 11 of the patients were staged as T1a while 5 were staged as T1b...
  96. ncbi Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring
    Sandeep S Karajanagi
    Department of Surgery, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 120:175-84. 2011
    ..By using a US Food and Drug Administration-approved polymer, polyethylene glycol (PEG), we created a novel hydrogel (PEG30) and investigated its effects on multiple vocal fold structural and functional parameters...
  97. ncbi 'Mixing' the registers: glottal source or vocal tract?
    Donald G Miller
    Groningen Voice Research Laboratory, Department of Biomedical Engineering, AO, University Medical Center Groningen, Groningen, The Netherlands
    Folia Phoniatr Logop 57:278-91. 2005
    ..The results suggest that the skillful tuning of the resonances of the vocal tract contributes more toward the pedagogical goal of smoothing the register transition than does a presumed mixing of the registers at the glottal source...
  98. ncbi Midmembranous vocal fold lamina propria proteoglycans across selected species
    Mariah S Hahn
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Ann Otol Rhinol Laryngol 114:451-62. 2005
    ..We examined the proteoglycan (PG) and associated sulfated glycosaminoglycan (GAG) content of the midmembranous vocal fold lamina propria (LP) of humans, dogs, pigs, and ferrets...
  99. ncbi Reinke's edema and risk factors: clinical and histopathologic aspects
    Dario Marcotullio
    Department of Otorhinolaryngology, La Sapienza University, Rome, Italy
    Am J Otolaryngol 23:81-4. 2002
    ..The purpose of this study was to evaluate retrospectively the distribution of histologic damage and its correlation with various risk factors in a group of patients affected by Reinke's edema...
  100. ncbi Vocal fold proteoglycans and their influence on biomechanics
    S D Gray
    National Center for Voice and Speech, Department of Surgery, University of Utah School of Medicine, Salt Lake City 84113, USA
    Laryngoscope 109:845-54. 1999
    ..To examine the interstitial proteins of the vocal fold and their influence on the biomechanical properties of that tissue...
  101. ncbi Elasticity of human vocal folds measured in vivo using color Doppler imaging
    Tzu Yu Hsiao
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan
    Ultrasound Med Biol 28:1145-52. 2002
    ..However, in the range of lower pitch, the VF stress was relatively linear with respect to the strains and the Young's moduli were about 30 to 120 kPa in men and 120 to 300 kPa in women...

Research Grants48

  1. Laser photothermolysis of scar in vocal cords
    Elie Rebeiz; Fiscal Year: 2002
    ..This immunoconjugate assisted laser minimally invasive therapy, if success, will certainly provide an excellent alternative to current therapy in the prevention and treatment of hypertrophic scar formation. ..
  2. Pathophysiology of Spasmodic Dysphonia: a TMS study
    Teresa Jacobson Kimberley; Fiscal Year: 2013
    ..Adductor spasmodic Dysphonia (AdSD) is a type of focal dystonia that affects the muscles of the vocal cords and can severely impair the ability to speak...
  3. Dynamic Vocal Fold Abduction for Bilateral Paralysis
    Michael Broniatowski; Fiscal Year: 2006
    ..The closed position of the vocal cords seen in such cases results in major compromise of the ability to breathe through the natural passages (nose and ..
  4. Voice-preserving Treatment of Larynegeal Papilloma
    Zhi Wang; Fiscal Year: 2006
    ..This disease usually involves the vocal cords or other regions of the larynx, thereby, resulting in a poor voice...
  5. AN ECM SCAFFOLD FOR HEAD AND NECK REPAIR
    Alan Spievack; Fiscal Year: 2000
    ..third specific aim will evaluate the utility of the multilaminate UBS construct in a dog pilot study in which vocal cords are excised and replaced by the UBS scaffold...
  6. Voice-preserved therapy of laryngeal papilloma in children
    Zhi Wang; Fiscal Year: 2009
    ..This disease usually involves the vocal cords or other regions of the larynx, thereby, resulting in a poor voice...
  7. BASEMENT MEMBRANE ZONE IN VOCAL INJURY
    Steven Gray; Fiscal Year: 1993
    ..be performed to determine the population density of the attaching BMZ structures in normal human and canine vocal cords. Since dermatiological studies have shown variation in population densities of attaching structures across ..
  8. Laser Atraumatic Treatment of Ectasias on Vocal Cords
    Zhi Wang; Fiscal Year: 2006
    ..It would be safe and convenient enough for an out-patient treatment, without requiring a general anesthesia. [unreadable] [unreadable]..
  9. DEVELOPMENT OF A LARYNGEAL PACER
    Ira Sanders; Fiscal Year: 1992
    In the clinical disorder of bilateral vocal cord paralysis (BVCP), the nerves to the larynx are severed and the vocal cords cannot be abducted (opened) during inspiration...
  10. Quantitative Modeling of Speech
    Brad H Story; Fiscal Year: 2010
    ....
  11. Improved Measurements of Vocal Fold-Related Tissues
    Sarah Klemuk; Fiscal Year: 2006
    ..Surface roughness of plate and substrate surfaces will be quantified using SEM technology and Scanning Probe Microscopy. [unreadable] [unreadable]..
  12. Phytochemical Treatments for Vocal Fold Scar
    Bernard Rousseau; Fiscal Year: 2004
    ..abstract_text> ..
  13. The effects of strain on vocal fold fibroblasts
    Ryan Branski; Fiscal Year: 2004
    ..Furthermore, it seeks to provide in vitro data in conjunction with the Sponsor's current NIH ROI. ..
  14. A Computational Tool for Simulation of Phonosurgical Pr*
    Eric Hunter; Fiscal Year: 2006
    ..It is expected that the posturing model will have a significant impact on surgically based voice therapies, as well as on vocal fold modeling in general and post-surgical therapy. ..
  15. Electrode Array Reanimation of the Paralyzed Larynx
    Marshall Smith; Fiscal Year: 2006
    ..Nerve samples will be harvested and studied to examine the effects of the implanted array on RLN fibers. [unreadable] [unreadable]..
  16. Laryngeal hydration aerosol for prevention of voice disorders
    Kimberly Fisher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. RESEARCH TOWARD OCCUPATIONAL SAFETY IN VOCALIZATION
    Ingo Titze; Fiscal Year: 2009
    ..A multi-disciplinary research team has been assembled to address this public health concern at physical, biochemical, molecular, and behavioral levels of investigation. ..
  18. Electrical Stimulation of the Bilaterally Paralyzed Larynx Paced with Respiration
    David L Zealear; Fiscal Year: 2010
    ..This new, more dynamic approach to treatment could restore normal ventilation through the mouth without alteration of voice or swallowing, and return the patient to a physically active lifestyle. ..
  19. AEROACOUSTICS OF VOICE
    Fariborz Alipour; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. DYNAMIC PATTERNS OF SPEECH AERODYNAMICS IN CHILDREN
    LAURA KOENIG; Fiscal Year: 2003
    ....
  21. REHABILITATION OF THE PARALYZED LARYNX
    David Zealear; Fiscal Year: 2006
    ..With respect to the head and neck, FES could be employed initially to reanimate the unilaterally paralyzed face, larynx and pharynx, and in the process, direct natural reinnervation of these structures. ..
  22. Gender differences in changes of human vocal tract
    STEVE XUE; Fiscal Year: 2005
    ....
  23. REGULATION OF VOCAL FOLD HYDRATION AND PHONATION
    Kimberly Fisher; Fiscal Year: 2003
    ..A primary goal is the development of an R01 proposal by the candidate during years 3-4 of this project. ..
  24. NEUROMUSCULAR CONTROL OF THE LARYNX DURING PHONATION
    Ingo Titze; Fiscal Year: 2004
    ....
  25. PHONATION AND PHONATORY CONTROL IN VOCAL TREMORS
    Marshall Smith; Fiscal Year: 2002
    ..The experimental phase consists of studies of neuromuscular and respiratory input to the larynx. This information about vocal tremor will be applied to model simulations with the use of physiological signals as input model parameters. ..
  26. BIOREACTORS FOR TISSUES EXPOSED TO HIGH FREQUENCY VIBRATION
    Ingo R Titze; Fiscal Year: 2010
    ..01 - 2000 hz. ..
  27. Comparison of Two Therapies for UES Dysphagia
    Reza Shaker; Fiscal Year: 2004
    ..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
  28. Safety & effectiveness of HA hydrogels in immortalized vocal fold fibroblast cell
    Susan Thibeault; Fiscal Year: 2007
    ..Efforts from this R21 will provide imminent directions for an R01 focusing on human clinical trials for treatment of ECM disorders. [unreadable] [unreadable] [unreadable]..
  29. Fine Needle Aspiration of Benign Vocal Fold Lesions
    Susan Thibeault; Fiscal Year: 2004
    ..abstract_text> ..
  30. International Conference on Advances in Laryngeal Biophysiology
    Susan Thibeault; Fiscal Year: 2008
    ..The multifactorial nature of voice disorders necessitates study for a comprehensive understanding of the disease mechanisms for optimal treatment success. [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Flow Visualization in the Canine Larynx During Phonation
    Siddarth Khosla; Fiscal Year: 2006
    ..Training in recognizing clinical applications of the work will be fostered by consultations with two prominent laryngologists, Dr. Gerald Berke and Dr. Randal Paniello. ..
  32. Perception of Competing Talkers by the Hearing-Impaired
    CAROL MACKERSIE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    ..abstract_text> ..
  34. Phytochemicals and estrogen-enhanced cancers
    Karen Auborn; Fiscal Year: 2006
    ..We will use gene chip technology to look for induction or repression of other genes involved in apoptosis and cell cycle progression. ..
  35. SPEECH AND RESPIRATORY AERODYNAMICS IN CLEFT PALATE
    David Zajac; Fiscal Year: 2003
    ..It is possible, for example, that therapeutic techniques may be developed that incorporate specific respiratory strategies employed by speakers with cleft palate who exhibit acceptable speech characteristics. ..
  36. ANATOMIC DEVELOPMENT OF THE VOCAL TRACT--MRI PROCEDURES
    HOURI VORPERIAN; Fiscal Year: 2002
    ..The findings of this study contribute to knowledge on craniofacial development, and are of theoretical and clinical significance particularly in the areas of speech development and speech production. ..
  37. Expiratory muscle training in patients with Parkinson's
    Christine Sapienza; Fiscal Year: 2006
    ..The goals of the grant meet the mission of the R21. Its potential impact is high due to the therapy program's innovative nature and potential cost-effectiveness as a treatment approach. ..
  38. Aerodynamic and Acoustic Models of Phonation
    Ronald Scherer; Fiscal Year: 2007
    ..abstract_text> ..
  39. JWatcher-event recorder and behavioral analysis program
    DANIEL BLUMSTEIN; Fiscal Year: 2004
    ..While we will continue to freely-distribute the software, on-going support and routine updates will be supported by the sales of a detailed users manual, which will include laboratory exercises suitable for teaching. ..
  40. Visual Contributions to Speech Perception
    Kevin Munhall; Fiscal Year: 2007
    ..The studies will contribute to the understanding of how visual stimulus properties and higher level processes determine gaze patterns and thus influence perception. ..
  41. Tongue Strength Exercise and Swallowing in Oral Cancer
    Cathy Lazarus; Fiscal Year: 2007
    ..Dependant variables include maximum tongue strength, temporal swallow measures of oral and pharyngeal transit times, bolus volume and viscosity, the Oropharyngeal Swallow Efficiency (OPSE) measure, and quality of life ratings. ..
  42. Patho-Genetic Explorations of Myotilin, the LGMD1A Gene
    SEAN GARVEY; Fiscal Year: 2007
    ..I will also characterize a novel myotilin isoform that is expressed predominantly in cardiac muscle, and continue to genotype myotilin SNPs in an expanding set of DCM patients. ..
  43. Chaos in Human Phonation and Its Measurement
    Jack Jiang; Fiscal Year: 2007
    ..The sensitivity and specificity of nonlinear dynamic parameters in distinguishing normal from pathologic voices will be assessed based on the received operating characteristic (ROC) analysis. [unreadable] [unreadable]..
  44. Aerodynamic and Acoustic Models of Phonation
    Ronald Scherer; Fiscal Year: 2006
    ..This research program is a collaboration among laboratories at Bowling Green State University, Purdue University, the University of Toledo, and Washington University in Saint Louis. ..
  45. Biophysiological Mechanisms of 'Heightened Speech'
    Katherine Verdolini; Fiscal Year: 2007
    ..The primary dependent variable is quality of life in relation to voice, measured with the Voice Handicap Index. Secondary variables are aerodynamic, laryngeal, and vocal quality measures. [unreadable] [unreadable]..
  46. Phytochemicals, ER-Stress and Prostate Cancer
    Karen Auborn; Fiscal Year: 2007
    ..Moreover, combinations of nutrients may work together and at lower concentrations to target cancer cells. ..
  47. Early Assessment of Infants with Cleft Palate Following Surgical Repair
    David Zajac; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..