larynx

Summary

Summary: An irregularly shaped, musculocartilaginous tubular structure, lined with mucous membrane, located at the top of the trachea and below the root of the tongue and the hyoid bone. It is the essential sphincter guarding the entrance into the trachea and functioning secondarily as the organ of voice.

Top Publications

  1. ncbi Acute external laryngotracheal trauma: diagnosis and management
    Walter T Lee
    Head and Neck Institute, The Cleveland Clinic, 9500 Euclid Ave, Desk A 71, Cleveland, OH 44195, USA
    Ear Nose Throat J 85:179-84. 2006
  2. ncbi Type 1 laryngeal cleft: establishing a functional diagnostic and management algorithm
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States
    Int J Pediatr Otorhinolaryngol 70:2073-9. 2006
  3. ncbi Swing of the pendulum: optimizing functional outcomes in larynx cancer
    F Christopher Holsinger
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030, USA
    Curr Oncol Rep 10:170-5. 2008
  4. doi Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma
    S Filou
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochimie 95:725-34. 2013
  5. pmc Radiation dose-volume effects in the larynx and pharynx
    Tiziana Rancati
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 76:S64-9. 2010
  6. pmc Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer
    Arlene A Forastiere
    Sydney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Clin Oncol 31:845-52. 2013
  7. ncbi In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patients
    Brian J F Wong
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California, USA
    Laryngoscope 115:1904-11. 2005
  8. ncbi Laryngeal elevation achieved by neuromuscular stimulation at rest
    Theresa A Burnett
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1416, USA
    J Appl Physiol (1985) 94:128-34. 2003
  9. doi Functional MRI assessment of orofacial articulators: neural correlates of lip, jaw, larynx, and tongue movements
    Krystyna Grabski
    GIPSA lab, Département Parole and Cognition, UMR CNRS 5216, Grenoble Universités, France
    Hum Brain Mapp 33:2306-21. 2012
  10. pmc Subglottal pressure, tracheal airflow, and intrinsic laryngeal muscle activity during rat ultrasound vocalization
    Tobias Riede
    Dept of Biology and National Center for Voice and Speech, Univ of Utah, Salt Lake City, UT 84112, USA
    J Neurophysiol 106:2580-92. 2011

Detail Information

Publications348 found, 100 shown here

  1. ncbi Acute external laryngotracheal trauma: diagnosis and management
    Walter T Lee
    Head and Neck Institute, The Cleveland Clinic, 9500 Euclid Ave, Desk A 71, Cleveland, OH 44195, USA
    Ear Nose Throat J 85:179-84. 2006
    ..Although there is some controversy regarding care, treatment in experienced hands will usually result in a favorable outcome. In this article, we review and update the diagnosis and management of acute external laryngotracheal trauma...
  2. ncbi Type 1 laryngeal cleft: establishing a functional diagnostic and management algorithm
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, United States
    Int J Pediatr Otorhinolaryngol 70:2073-9. 2006
    ..To report our experience with all patients diagnosed with type 1 laryngeal cleft over a period of 3 years in our referral practice and to describe a functional diagnostic and management algorithm for children with this disorder...
  3. ncbi Swing of the pendulum: optimizing functional outcomes in larynx cancer
    F Christopher Holsinger
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030, USA
    Curr Oncol Rep 10:170-5. 2008
    ..Incorporation of these new approaches advances the concept of personalized medicine, with treatment strategies tailored to the circumstances and future of each patient...
  4. doi Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma
    S Filou
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochimie 95:725-34. 2013
    ..organization and localization of ADAMTS-1, ADAMTS-4/aggrecanase-1 and ADAMTS-5/aggrecanase-2 in human normal larynx and laryngeal squamous cell carcinoma (LSCC) were investigated...
  5. pmc Radiation dose-volume effects in the larynx and pharynx
    Tiziana Rancati
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 76:S64-9. 2010
    ..For late dysphagia, a major issue is accurate definition and uncertainty of the relevant anatomical structures. These and other issues are discussed...
  6. pmc Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer
    Arlene A Forastiere
    Sydney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Clin Oncol 31:845-52. 2013
    To report the long-term results of the Intergroup Radiation Therapy Oncology Group 91-11 study evaluating the contribution of chemotherapy added to radiation therapy (RT) for larynx preservation.
  7. ncbi In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patients
    Brian J F Wong
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California, USA
    Laryngoscope 115:1904-11. 2005
    ..Patients undergoing surgical head and neck endoscopy were examined using a fiberoptic OCT imaging probe to study and characterize microstructural anatomy and features of the larynx and benign laryngeal pathology in vivo.
  8. ncbi Laryngeal elevation achieved by neuromuscular stimulation at rest
    Theresa A Burnett
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1416, USA
    J Appl Physiol (1985) 94:128-34. 2003
    ..stimulation of select muscles was evaluated to determine which single muscle or muscle pair best elevates the larynx and should be considered during future studies of neuromuscular stimulation in dysphagic patients...
  9. doi Functional MRI assessment of orofacial articulators: neural correlates of lip, jaw, larynx, and tongue movements
    Krystyna Grabski
    GIPSA lab, Département Parole and Cognition, UMR CNRS 5216, Grenoble Universités, France
    Hum Brain Mapp 33:2306-21. 2012
    ..These results provide evidence for a core neural network involved in laryngeal and supralaryngeal motor control and further refine the sensorimotor somatotopic organization of orofacial articulators...
  10. pmc Subglottal pressure, tracheal airflow, and intrinsic laryngeal muscle activity during rat ultrasound vocalization
    Tobias Riede
    Dept of Biology and National Center for Voice and Speech, Univ of Utah, Salt Lake City, UT 84112, USA
    J Neurophysiol 106:2580-92. 2011
    ..Many features of the laryngeal muscle activation pattern during ultrasound vocalization in rats are shared with other mammals...
  11. ncbi Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases
    Lester D R Thompson
    Department of Endocrine and Otorhinolaryngic Head and Neck Pathology, Armed Forces Institute of Pathology, Building 54, 6825 16th Street NW, Washington, DC 20306 6000, U S A
    Am J Surg Pathol 26:153-70. 2002
    ..Recurrences developed in 85 (45%) patients. Overall, T1 glottic tumors managed by complete surgical eradication had the best outcome (mean follow-up, 7.8 years)...
  12. ncbi Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and the adductor pollicis
    K Kirov
    Department of Anesthesia, Hopital Henri Mondor, AP HP, University of Paris XII, Paris, France
    Acta Anaesthesiol Scand 48:577-81. 2004
    ..To understand this discrepancy better, we evaluated the potency and onset of atracurium and cisatracurium directly at the larynx adductors in humans.
  13. doi Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial)
    Andreas Dietz
    Department of Otolaryngology, University of Leipzig, Germany
    Eur Arch Otorhinolaryngol 266:1291-300. 2009
    A prospective multicenter phase-II trial (12 centers) was performed by the German larynx organ preservation group (DeLOS) to evaluate the effect of induction chemotherapy (ICHT) with paclitaxel/cisplatin (TP), followed by accelerated-..
  14. ncbi Voices of the dead: complex nonlinear vocal signals from the larynx of an ultrasonic frog
    Roderick A Suthers
    School of Medicine, Department of Biology, and Program for Neuroscience, Jordan Hall, 1001 E Third Street, Indiana University, Bloomington, IN 47405, USA
    J Exp Biol 209:4984-93. 2006
    ..of its calls, responsible for this frog's vocal diversity, can be generated by forcing pressurized air through the larynx of euthanized males...
  15. ncbi Role of vertical larynx movement and cervical lordosis in F0 control
    K Honda
    ATR Human Information Processing Research Laboratories, Kyoto, Japan
    Lang Speech 42:401-11. 1999
    The role of vertical larynx movement in vocal frequency (F0) change has attracted the attention of many researchers...
  16. ncbi Radiation doses to structures within and adjacent to the larynx are correlated with long-term diet- and speech-related quality of life
    Ken Dornfeld
    Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Int J Radiat Oncol Biol Phys 68:750-7. 2007
    ..To test the hypothesis that radiation dose to key sites in the upper aerodigestive tract is associated with long-term functional outcome after (chemo)radiotherapy for head-and-neck cancers...
  17. doi Larynx preservation
    Jean Louis Lefebvre
    Head and Neck Department, Centre Oscar Lambret, Lille, France
    Curr Opin Oncol 24:218-22. 2012
    Organ preservation, in particular larynx preservation, is a major challenge that has been evaluated during the past 3 decades. This review took in consideration the most recently published articles on this topic.
  18. ncbi Dynamic imaging of swallowing in a seated position using open-configuration MRI
    Yasutoshi Honda
    Department of Oral and Maxillofacial Radiology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Magn Reson Imaging 26:172-6. 2007
    ..To assess the feasibility of dynamic MRI of swallowing in a seated position using an open-configuration MRI scanner, and to compare its capacity for motion analysis around the pharyngeal wall with that of videofluorography...
  19. doi Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy
    Hale B Caglar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 72:1110-8. 2008
    ..To evaluate early swallowing after intensity-modulated radiotherapy for head and neck squamous cell carcinoma and determine factors correlating with aspiration and/or stricture...
  20. ncbi Cortico-cortical projections of the motorcortical larynx area in the rhesus monkey
    Kristina Simonyan
    Department of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Brain Res 949:23-31. 2002
    The efferent cortico-cortical projections of the motorcortical larynx area were studied in three rhesus monkeys (Macaca mulatta), using biotin dextranamine as anterograde tracer...
  21. ncbi Mifepristone (RU-486) impairs post-surgical wound healing of the larynx
    Ion Tcacencu
    Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Med Sci Monit 8:BR397-400. 2002
    ..The purpose of this study was to examine how RU486 (mifepristone), a glucocorticoid antagonist, affects the regeneration process in a rabbit laryngeal wound-healing model...
  22. ncbi Air bag injury as a cause of inflammatory myofibroblastic pseudotumour of the subglottic larynx progressing to myositis ossificans
    A Alaani
    Department of ENT, Queen Elizabeth Hospital, Birmingham, UK
    Acta Otolaryngol 125:674-7. 2005
    ..The most frequently affected organ is the lung; a much less common site is the larynx and subglottic involvement is particularly rare...
  23. doi The nose oropharynx hypopharynx and larynx (NOHL) classification: a new system of diagnostic standardized examination for OSAHS patients
    Claudio Vicini
    ENT Unit, Department of Special Surgery, Morgagni Pierantoni Hospital, Via Forlanini no 34, 47121 Forli, Italy
    Eur Arch Otorhinolaryngol 269:1297-300. 2012
    ....
  24. pmc Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 26:223-31. 2013
    ..058). Thus, it appears that the role of HPV is more complex in the larynx than in the oropharynx, and that CDKN2A(p16) and CDKN1A(p21) expression may not reflect HPV-driven tumors in most ..
  25. pmc Asymmetric spatiotemporal chaos induced by a polypoid mass in the excised larynx
    Yu Zhang
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792 7375, USA
    Chaos 18:043102. 2008
    ..the laryngeal pathology of a vocal polyp is experimentally observed using high-speed imaging in an excised larynx. Spatiotemporal analysis reveals that the normal vocal folds show spatiotemporal correlation and symmetry...
  26. ncbi Asymptomatic bilateral mixed-type laryngocele and laryngeal carcinoma
    Yucel Akbas
    Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey
    Eur Arch Otorhinolaryngol 261:307-9. 2004
    ..We discuss the possible etiopathogenetic influence of increased intralaryngeal pressure with preoperative CT and explorative findings, and the current literature is reviewed...
  27. doi Complex vibratory patterns in an elephant larynx
    Christian T Herbst
    Laboratory of Bio Acoustics, Department of Cognitive Biology, University of Vienna, Althanstraße 14, 1090 Wien, Austria
    J Exp Biol 216:4054-64. 2013
    ..To date, little is known in detail about the vibratory phenomena in the elephant larynx. Here, we provide a first descriptive report of the complex oscillatory features found in the excised larynx of a ..
  28. ncbi Distribution and prognostic significance of cell cycle proteins in squamous carcinoma of the larynx, hypopharynx and adjacent epithelial hyperplastic lesions
    Metka Volavsek
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Laryngol Otol 117:286-93. 2003
    ..Our study demonstrated derailment of cell cycle regulation in almost all cases of SCC of the larynx and hypopharynx...
  29. ncbi The association of laryngoceles with squamous cell carcinoma of the larynx presenting as a deep neck infection
    O Akdogan
    Ankara Numune Education and Research Hospital, 4th ENT Clinic, Ankara, Turkey
    B-ENT 3:209-11. 2007
    ..We present a case of an external laryngocele with laryngeal carcinoma...
  30. doi Larynx transplantation: laryngectomees' opinion poll
    Guillaume Buiret
    ENT Unit, Lyon Sud Regional and Universitary Hospital, Pierre Benite, France
    Transplantation 84:1584-9. 2007
    In 1998, Strome et al. performed the first human larynx transplantation in a patient with larynx traumatism...
  31. ncbi Development of the supralaryngeal vocal tract in Japanese macaques: implications for the evolution of the descent of the larynx
    Takeshi Nishimura
    Laboratory of Physical Anthropology, Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Am J Phys Anthropol 135:182-94. 2008
    ..This configuration develops from the great descent of the larynx relative to the palate, which is accomplished through both the descent of the laryngeal skeleton relative to the ..
  32. pmc Loss of heterozygosity on chromosomes 3p,8p,9p and 17p in the progression of squamous cell carcinoma of the larynx
    Woo Jeong Yoo
    Department of Otolaryngology HNS, The Catholic University of Korea, College of Medicine, Seoul, Korea
    J Korean Med Sci 19:345-51. 2004
    ..The results suggest that 9p21 in the early event, 17p13.1, 3p25 and 3p14.2 in the intermediate event and 8p21.3- p22 in the late event may be involved in the laryngeal carcinogenesis...
  33. ncbi Imaging of the post-treatment larynx
    Suresh K Mukherji
    Department of Radiology, University of Michigan Health System, UH B2B311, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0030, USA
    Eur J Radiol 44:108-19. 2002
    ..The intent of this manuscript will be to review the post-treatment appearance of the larynx following RT and various types of laryngectomy.
  34. ncbi Comparison of direct and video-assisted views of the larynx during routine intubation
    Marshal B Kaplan
    Department of Anesthesiology, UCLA and Cedars Sinai Medical Center, Los Angeles, CA 90095, USA, and Department of Anesthesiology, Cantonal Hospital, St Gallen, Switzerland
    J Clin Anesth 18:357-62. 2006
    ..To compare the direct and indirect (video monitor) views of the glottic opening using a new Macintosh blade that is modified to provide a video image of airway structures during laryngoscopy...
  35. ncbi Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level
    Devrim Sarikaya
    Department of Bioengineering, Faculty of Engineering, Ege University, Izmir, 35100 Turkey
    Biopharm Drug Dispos 27:353-9. 2006
    ..The aim of this study was to analyse the expression of the individual forms of CYP at the mRNA level in human larynx and quantitatively to compare their expressions in human liver, the main organ of CYP expression...
  36. ncbi [The expressions of protein kinase CK2alpha in squamous cell carcinoma of larynx and its clinical significance]
    Jianting Wang
    Department of Otorhinolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 20:412-4. 2006
    To investigate the expression of Protein kinase CK2alpha in squamous cell carcinoma of larynx (LSCC) and to evaluate its clinical significance.
  37. ncbi Larynx-sparing radiotherapy for squamous cell carcinoma from an unknown head and neck primary site
    Christopher A Barker
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Clin Oncol 28:445-8. 2005
    The objective of this study was to evaluate the efficacy of larynx-sparing radiotherapy (RT) alone or in combination with a neck dissection for patients with squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head ..
  38. doi Localization of transient receptor potential vanilloid (TRPV) in the human larynx
    Takao Hamamoto
    Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Acta Otolaryngol 129:560-8. 2009
    Transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 were expressed in the human larynx, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation and osmotic sensation, ..
  39. ncbi Expression of matrix metalloproteinase-9 in patients with squamous cell carcinoma of the larynx
    Zavisa Colović
    University of Split, Split University Hospital Center, ENT Department, Split, Croatia
    Coll Antropol 37:151-5. 2013
    ..Study included 196 patients with squamous cell carcinoma of the larynx treated at ENT Department, Split University Hospital Centre, from January 1, 2000 till December 31, 2009...
  40. doi Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population
    Jiwen Wang
    Department of Thoracic Surgery, Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou 310022, China
    Gene 524:193-6. 2013
    ..However, their roles in the development of larynx and hypopharynx squamous cell carcinoma (SCC) were still unknown in the Chinese...
  41. doi Management of laryngeal fractures--a 10-year experience
    Scharukh Jalisi
    Department of Otolaryngology Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Voice 25:473-9. 2011
    ..Herein, we present one of the largest series of management of laryngeal and tracheal fractures from a tertiary care level I trauma center...
  42. doi Evaluation of swallowing using 320-detector-row multislice CT. Part II: kinematic analysis of laryngeal closure during normal swallowing
    Yoko Inamoto
    Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, 1 98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470 1192, Japan
    Dysphagia 26:209-17. 2011
    ..320-MSCT allowed the 3D depiction and kinematic analysis of target structures, which will increase our knowledge of airway protection mechanisms during swallowing...
  43. doi Long-term retention of a 3-dimensional educational computer model of the larynx: a follow-up study
    Dieter Fritz
    Department of Otolaryngology Head and Neck Surgery, University of Western Ontario, London, Canada
    Arch Otolaryngol Head Neck Surg 137:598-603. 2011
    To determine the long-term retention of a 3-dimentional (3-D) educational computer model of the larynx to teach laryngeal anatomy and to compare it with standard written instruction (SWI).
  44. ncbi Experimental device for detecting laryngeal movement during swallowing
    Shinichi Abe
    Oral Health Science Center, Department of Anatomy, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    Bull Tokyo Dent Coll 43:199-203. 2002
    ..It has also been reported that along with this movement, the larynx elevates in an antero-superior direction...
  45. doi Histological and immunohistochemical study of the expression of p53 and ki-67 proteins in the mucosa of the tongue, pharynx and larynx of rats exposed to cigarette smoke
    Graziela de Oliveira Semenzati
    Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Student of Botucatu Medical School, Sao Paulo State University UNESP, Botucatu, Brazil
    Inhal Toxicol 24:723-31. 2012
    Head and neck cancers are linked to smoking. The most affected sites are the oral cavity, pharynx and larynx. Experimental studies show epithelial lesions caused by cigarette smoke.
  46. ncbi Motions of the posterior pharyngeal wall in human swallowing: a quantitative videofluorographic study
    J B Palmer
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University and Good Samaritan Hospital, Baltimore, MD, USA
    Arch Phys Med Rehabil 81:1520-6. 2000
    ..To quantify segmental motions of the posterior pharyngeal wall during swallowing...
  47. ncbi Clinical and electrophysiological characteristics of larynx in myasthenia gravis
    Wen Xu
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China
    Ann Otol Rhinol Laryngol 118:656-61. 2009
    We investigated the clinical and electrophysiological characteristics of the larynx in patients with myasthenia gravis (MG).
  48. doi Gender effects on airway closure in normal subjects
    Atsuko Kurosu
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, 3 358, Evanston, IL 60208, USA
    Dysphagia 25:284-90. 2010
    ..0001) and cricopharyngeal opening (P < 0.0001). During liquid barium swallows there was a linear increase in both the duration of laryngeal closure and cricopharyngeal opening...
  49. doi Reconstruction of the larynx and aryepiglottic fold using a free radial forearm tendocutaneous flap after partial laryngopharyngectomy: a case report
    Makoto Mihara
    Department of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Microsurgery 32:50-4. 2012
    ..underwent partial laryngopharyngectomy, lymphadenectomy in the right neck, tracheostomy, and reconstruction of the larynx and aryepiglottic fold with a free radial forearm flap and the associated vascularized palmaris longus tendon...
  50. ncbi Ontogeny of postnatal hyoid and larynx descent in humans
    D E Lieberman
    Department of Anthropology, The George Washington University, 2110 G St, NW, Washington, DC 20052, USA
    Arch Oral Biol 46:117-28. 2001
    Postnatal descent of the hyoid and larynx relative to the palate and mandible, which occurs uniquely in humans, is an anatomical prerequisite for quantal speech...
  51. ncbi Aerodigestive injuries of the neck
    P Vassiliu
    Department of Surgery, University of Southern California, Los Angeles, USA
    Am Surg 67:75-9. 2001
    ..Loss of airway after rapid sequence induction is a potentially lethal complication and the trauma team should be ready for a surgical airway. Repair of laryngotracheal injuries without a protective tracheostomy is safe in selected cases...
  52. doi Tissue-engineered larynx using perfusion-decellularized technique and mesenchymal stem cells in a rabbit model
    Nan Hou
    Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital, Chengdu Medical College, Sichuan Province, PR China
    Acta Otolaryngol 131:645-52. 2011
    ..stem cells (MSCs) into the decellularized laryngeal muscle matrix for construction of a tissue-engineered larynx is feasible...
  53. ncbi Audiovocal interactions during development? Vocalisation in deafened young horseshoe bats vs. audition in vocalisation-impaired bats
    R Rubsamen
    Zoological Department, University of Kelaniya, Sri Lanka
    J Comp Physiol A 167:771-84. 1990
    ..Frequency control of echolocation pulses was disrupted by larynx denervation...
  54. doi Larynx preservation clinical trial design: summary of key recommendations of a consensus panel
    K Kian Ang
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Oncologist 15:25-9. 2010
    An international consensus panel was convened to develop guidelines for the conduct of phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and hypopharyngeal cancer...
  55. pmc Smooth operator: avoidance of subharmonic bifurcations through mechanical mechanisms simplifies song motor control in adult zebra finches
    Coen P H Elemans
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 30:13246-53. 2010
    ..Consistent with this view is the presence of high fidelity at every level of motor control, from telencephalic premotor areas to superfast syringeal muscles...
  56. doi The larynx for neurologists
    Tanya K Meyer
    Department of Otolaryngology, University of Maryland, Baltimore, MD, USA
    Neurologist 15:313-8. 2009
    The larynx is an amazingly versatile musculocartilaginous organ with complex sensory and motor responsibilities which allow functional coordination of the upper aerodigestive tract.
  57. ncbi Acute external laryngeal trauma: experience with 112 patients
    Allen P Butler
    Department of Otolaryngology Head and Neck Surgery, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann Otol Rhinol Laryngol 114:361-8. 2005
    ....
  58. doi A newly identified variation at the entry of the recurrent laryngeal nerve into the larynx
    Tanglei Shao
    Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Invest Surg 23:314-20. 2010
    ..We aimed to highlight a new anatomical variation of the recurrent laryngeal nerve (RLN), and to emphasize its implications for thyroid surgery...
  59. ncbi Amyloidosis concurrently involving the sinonasal cavities and larynx
    Shy Chyi Chin
    Department of Radiology, Tri Service General, Hospital, Taipei, Taiwan
    AJNR Am J Neuroradiol 25:636-8. 2004
    ..case of a 21-year-old man who had localized amyloidosis simultaneously involving the sinonasal cavities and the larynx. The rarer sinonasal lesion demonstrated CT findings of adjacent "fluffy" bone changes, possibly ..
  60. ncbi Ultrasound measurements of the diameter of the fetal trachea, larynx and pharynx throughout gestation applicability to prenatal diagnosis of obstructive anomalies of the upper respiratory-digestive tract
    K D Kalache
    Department of Obstetrics and Gynaecology, Campus Charite Mitte, Universitätsklinikum Medizinische Fakultät der Humboldt Universität zu Berlin, Germany
    Prenat Diagn 19:211-8. 1999
    ..Sonographic measurements of the diameters of the trachea, larynx and pharynx were obtained at well-defined planes from a prospective cross-sectional sample of 198 normal patients ..
  61. pmc Optical coherence tomography of the larynx in the awake patient
    Ali Sepehr
    Department of Otolaryngology Head and Neck Surgery, University of California, Irvine, CA, USA
    Otolaryngol Head Neck Surg 138:425-9. 2008
    To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system.
  62. doi Primary moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx: A case report with immunohistochemical and molecular study
    Giovanna Giordano
    Department of Pathology, Parma University, Italy
    Auris Nasus Larynx 36:228-31. 2009
    ..paper, we report the case of a moderately differentiated neuroendocrine carcinoma NEC (atypical carcinoid) of the larynx in a heavy smoker 67-year-old woman, with a history of hoarseness, dysphagia and dyspnea...
  63. ncbi View of the larynx obtained using the Miller blade and paraglossal approach, compared to that with the Macintosh blade
    B Achen
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    Anaesth Intensive Care 36:717-21. 2008
    ..to determine if laryngoscopy using a Miller blade with a paraglossal approach would yield an improved view of the larynx compared to that obtained with a Macintosh blade using the standard approach...
  64. ncbi Proliferation of myofibroblasts in the stroma of epithelial hyperplastic lesions and squamous carcinoma of the larynx
    Nina Zidar
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia
    Oncology 62:381-5. 2002
    ..The immunohistochemical phenotype, distribution and significance of proliferation of myofibroblasts in laryngeal epithelial hyperplastic lesions (EHL) and squamous carcinoma (SC) were analyzed...
  65. ncbi Leeches in the larynx
    I Kaygusuz
    Department of Otolaryngology, Firat University School of Medicine, Elazig, Turkey
    Eur Arch Otorhinolaryngol 258:455-7. 2001
    ..Indirect laryngoscopy revealed a dark greenish living foreign body in the larynx in each case...
  66. ncbi Distribution of class I and II human leukocyte antigens in the larynx
    Edward C Wang
    Department of Surgery, Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA Los Angeles, Los Angeles, CA, USA
    Otolaryngol Head Neck Surg 134:280-7. 2006
    To examine the antigenic distribution of human leukocyte antigens (HLA) of the human larynx.
  67. ncbi Nonlinear dynamics of phonations in excised larynx experiments
    Jack J Jiang
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792 7375, USA
    J Acoust Soc Am 114:2198-205. 2003
    ..including correlation dimension and Lyapunov exponents are applied to quantitatively analyze phonations in excised larynx experiments. Irregular phonations are typically characterized by aperiodic waveforms and broadband spectra...
  68. ncbi Larynx preservation surgery for advanced posterior pharyngeal wall carcinoma with free flap reconstruction: a critical appraisal
    Jan Kees A D Jol
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, PO Box 7057, 1007 MB, The, Amsterdam, Netherlands
    Oral Oncol 39:552-8. 2003
    To report the functional and oncologic results of larynx preservation surgery with free flap reconstruction for posterior pharyngeal wall carcinoma. Retrospective medical chart review. Tertiary care referral center...
  69. ncbi Whole genome analysis of human papillomavirus genotype 11 from cervix, larynx and lung
    Jira Chansaenroj
    Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Asian Pac J Cancer Prev 13:2619-23. 2012
    ..In this study HPV11 positive specimens were selected from cervix, larynx and lung biopsy tissue to analyze the whole genome by PCR and direct sequencing...
  70. doi Bifurcations and chaos in register transitions of excised larynx experiments
    Isao T Tokuda
    School of Information Science, Japan Advanced Institute of Science and Technology, Ishikawa 923 1292, Japan
    Chaos 18:013102. 2008
    Experimental data from an excised larynx are analyzed in the light of nonlinear dynamics. The excised larynx provides an experimental framework that enables artificial control and direct observation of the vocal fold vibrations...
  71. ncbi Management of acute laryngeal trauma
    I Eliachar
    Department of Otolaryngology and Communitive Disorders, Cleveland Clinic Foundation, Ohio, USA
    Acta Otorhinolaryngol Belg 50:151-8. 1996
    The larynx, by nature, is rightfully a very protected organ, being the bottleneck of the airway and the protective gate to the lungs...
  72. ncbi Localization of fibroblast growth factor-1 in cholinergic neurons innervating the rat larynx
    Hiroyuki Okano
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa cho, Otsu 520 2192, Japan
    J Histochem Cytochem 54:1061-71. 2006
    ..To test this hypothesis, we investigated the localization of FGF1 in cholinergic neurons innervating the rat larynx by immunohistochemistry using central-type antibodies to choline acetyltransferase (cChAT) and peripheral type (..
  73. doi [Laryngeal alterations following endotracheal intubation and use of larynx masks]
    M Echternach
    Freiburger Institut für Musikermedizin, Universitatsklinik Freiburg, Breisacherstrasse 60, 79106, Freiburg, Deutschland
    HNO 59:485-98. 2011
    ..Most prevalently, swollen mucosa, hematomas, granuloma and edema in the larynx can be observed after intubation. Limitations of respiratory vocal fold mobility appear less frequently...
  74. ncbi Laryngeal branching pattern of the inferior laryngeal nerve, before entering the larynx
    Bulent Yalcin
    Department of Anatomy, Gulhane Military Medical Academy, Ankara, Turkey
    Surg Radiol Anat 28:339-42. 2006
    ..the laryngeal branching pattern of the inferior laryngeal nerve (ILN) in detail before the branches entered the larynx. In 49 specimens 96 sides were examined for this project, including 27 males and 22 female cadavers. In 7 sides (7...
  75. ncbi Soft tissue response of the rabbit larynx to Gore-Tex implants
    Steve Cashman
    Department of Otolaryngology Head and Neck Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7777, USA
    Ann Otol Rhinol Laryngol 111:977-82. 2002
    ..this laryngeal implant has performed well, but no animal studies evaluating the use of this implant in the larynx have been published...
  76. pmc Sexually differentiated, androgen-regulated, larynx-specific myosin heavy-chain isoforms in Xenopus tropicalis; comparison to Xenopus laevis
    Laura A Baur
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Genes Evol 218:371-9. 2008
    ..that the sarcoplasmic myosin heavy-chain (MyHC) isoform xtMyHC-101d is highly and specifically expressed in the larynx of the aquatic anuran, Xenopus tropicalis...
  77. ncbi Internal fixation of comminuted cartilaginous fracture of the larynx with mini-plates
    Shofiq Islam
    University Hospitals of Coventry and Warwickshire NHS Trust, Department of Oral and Maxillofacial Surgery, Clifford Bridge Road, Coventry, United Kingdom
    Br J Oral Maxillofac Surg 45:321-2. 2007
    ..We illustrate a patient who sustained a severe penetrating laryngeal injury. His subsequent management was optimised by the joint intra-operative surgical collaboration between otorhinolaryngology and maxillofacial disciplines...
  78. ncbi Inflammatory myofibroblastic tumor of the larynx
    Sang Il Suh
    Department of Diagnostic Radiology, Korea University, School of Medicine, Seoul, South Korea
    Head Neck 28:369-72. 2006
    ..Inflammatory myofibroblastic tumor, composed of myofibroblastic spindle cells with acute and chronic inflammatory cells, is an unusual, benign solid mass that mimics a neoplastic process...
  79. ncbi Human cortical motor representation of the larynx as assessed by transcranial magnetic stimulation (TMS)
    Ralph M W Rödel
    University of Gottingen, Gottingen, Lower Saxonia, Germany
    Laryngoscope 114:918-22. 2004
    ....
  80. ncbi [IMOLA -- a new larynx model for surgical training. Education in transoral laser microsurgery of the upper airways]
    N Stasche
    Klinik fur Hals, Nasen und Ohrenheilkunde, Westpfalz Klinikum Kaiserslautern
    HNO 53:869-72, 874-5. 2005
    ..Education in laser microsurgery is generally acquired under the supervision of an experienced surgeon. During training phases, however, increased complication rates may occur. Viable models for training are therefore important...
  81. ncbi Intrafraction motions of the larynx during radiotherapy
    Bram van Asselen
    Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 56:384-90. 2003
    To quantify the intrafraction motions of the larynx during radiotherapy of laryngeal cancer...
  82. doi Three-dimensional imaging of the larynx for pre-operative planning of laryngeal framework surgery
    Claudio Storck
    Department of Otorhinolaryngology, Head and Neck Surgery and Phoniatrics, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    Eur Arch Otorhinolaryngol 267:557-63. 2010
    ..3D) rendering of high-resolution computerised tomography (HRCT), is suitable for 3D imaging of the larynx, analysis of laryngeal biomechanics and pre-operative planning...
  83. ncbi Extramedullary plasmacytoma of the larynx presenting with upper airway obstruction in a patient with long-standing IgD myeloma
    H S Uppal
    Department of Otolaryngology, Head and Neck Surgery, Russells Hall Hospital, Dudley, UK
    J Laryngol Otol 115:745-6. 2001
    A rare case of upper airway obstruction due to an extramedullary plasmacytoma of the larynx in a patient with long-standing IgD myeloma is presented...
  84. pmc Radionecrosis of the larynx: case report and review of the literature
    I Cukurova
    Department of ENT, Tepecik Medical Training Hospital, Izmir
    Acta Otorhinolaryngol Ital 30:205. 2010
    Aim of the present report is to describe a case of radionecrosis related to radiotherapy of the larynx and to review the literature...
  85. doi Quantifying the impact of androgen therapy on the female larynx
    Edward J Damrose
    Division of Laryngology, Department of Otolaryngology Head and Neck Surgery, Stanford University Medical Center, 801 Welch Road, Stanford, CA 94305, USA
    Auris Nasus Larynx 36:110-2. 2009
    ..To describe the timing of changes in fundamental frequency of the female voice following androgen therapy during female to male gender reassignment...
  86. ncbi [Chondromas and low-grade chondrosarcomas of the larynx: a case report]
    V Lemarchand
    Service ORL et Chirurgie Cervico Faciale, CHU, Avenue de la Cote de Nacre, 14033 Caen Cedex, France
    Ann Otolaryngol Chir Cervicofac 119:252-6. 2002
    We report a case of cricoid chondroma, underlining the difficulty in establishing a precise differential diagnosis between chondroma and low-grade chondrosarcoma of the larynx.
  87. doi Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification
    Marta Alonso Guervós
    Department of Otorhinolaryngology, IUOPA, Hospital Universitario Central de Asturias, Celestino Villamil s n, 33006 Oviedo, Asturias, Spain
    Oral Oncol 45:600-4. 2009
    Lymph nodes metastasis is a major risk factor related to poor survival in larynx and pharynx carcinomas...
  88. ncbi Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers
    T Ehtezazi
    School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, L3 3AF, UK
    Pharm Res 22:166-70. 2005
    ..In this study, the suitability of the upper airway models, obtained by applying a magnetic resonance imaging method, in simulating in vivo aerosol deposition data is determined...
  89. ncbi Laryngeal cleft type I: a novel method of repair using Bioplastique
    S Ahluwalia
    Department of Otolaryngology, The Lister Hospital, Stevenage, Herts, UK
    J Laryngol Otol 118:648-50. 2004
    ..This rare congenital anomaly usually presents in childhood but late presentation should be considered when adults present with lifelong dysphonia especially when associated with gastro-oesophageal reflux disease...
  90. ncbi The clinical relevance of the submucosal cricoid cleft
    Scott A Schraff
    Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Int J Pediatr Otorhinolaryngol 71:1099-104. 2007
    ..The submucosal cleft variant has been described anatomically, but not clinically. We describe a series of patients with a submucosal cricoid cleft variant and its clinical relevance...
  91. ncbi Congenital laryngotracheo-oesophageal cleft: successful ventilation with the Laryngeal Mask Airway
    Martin Jöhr
    Department of Anaesthesia, Children s, Luzern, Switzerland
    Paediatr Anaesth 13:68-71. 2003
    ..laryngotracheo-oesophageal cleft is a rare airway malformation which results from incomplete separation of the larynx and trachea from the hypopharynx and oesophagus...
  92. ncbi Type IV laryngotracheoesophageal clefts -- recent 5 year experience at Great Ormond Street Hospital for Children
    Z P Shehab
    Manchester Children s Hospital Booth Hall, Charlestown Road, Blackley, Manchester M9 2DD, UK
    Int J Pediatr Otorhinolaryngol 60:1-9. 2001
    ..Increased awareness of the condition and early diagnosis combined with aggressive, planned surgical intervention in centres of paediatric expertise should result in a significant reduction of current mortality...
  93. ncbi Repair of a type IV laryngotracheoesophageal cleft with cardiopulmonary bypass
    Alain K Moukheiber
    Department of Pediatric Otolaryngology Head and Neck Surgery, La Timone Children s Hospital, Marseille Medical School, Marseille, France
    Ann Otol Rhinol Laryngol 111:1076-80. 2002
    ..The child was extubated on the 12th postoperative day. The rationale for this method and its advantages in comparison with other surgical approaches are discussed...
  94. ncbi Strategies for managing Type IV laryngotracheoesophageal clefts at Great Ormond Street Hospital for Children
    Neeraj N Mathur
    Department of Paediatric Otolaryngology, Head and Neck Surgery, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK
    Int J Pediatr Otorhinolaryngol 70:1901-10. 2006
    ..To review our strategy for the treatment of patients with Type IV laryngotracheoesophageal cleft-a very rare congenital malformation...
  95. doi Anesthetic management of a neonate with type IV laryngotracheo-esophageal cleft
    Tsuyoshi Tagawa
    Division of Clinical Anesthesia, Mie University Hospital, Mie 514 8507, Japan
    Paediatr Anaesth 19:792-4. 2009
    ....
  96. doi Endoscopic repair of laryngeal cleft type I and type II: when and why?
    Reza Rahbar
    Department of Otolaryngology and Communication Enhancement, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Laryngoscope 119:1797-802. 2009
    ..To evaluate the clinical features of children with type I and type II laryngeal cleft and the role of conservative monitoring versus endoscopic repair in their management...
  97. doi Surgical management of type III and IV laryngotracheoesophageal clefts: the three-layered approach
    KENNETH GELLER
    Division of Otolaryngology Head and Neck Surgery, University of Southern California, Keck School of Medicine, Children s Hospital of Los Angeles, Los Angeles, CA 90027, United States
    Int J Pediatr Otorhinolaryngol 74:652-7. 2010
    ....
  98. ncbi Techniques and outcomes of laryngeal cleft repair: an update to the Great Ormond Street Hospital series
    Haytham Kubba
    Department of Paediatric Otolaryngology, Great Ormond Street Hospital for Children, London, England
    Ann Otol Rhinol Laryngol 114:309-13. 2005
    ..The rates of complication, revision surgery, and death were 54%, 26%, and 6%, respectively. Most of the children are now orally fed, and 9 still have a tracheotomy...
  99. ncbi The presentation and management of laryngeal cleft: a 10-year experience
    Reza Rahbar
    Department of Otolaryngology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 132:1335-41. 2006
    ..To review the presentation and associated congenital abnormalities of laryngeal cleft and present guidelines for its evaluation and management...
  100. ncbi Management and long-term follow-up of patients with types III and IV laryngotracheoesophageal clefts
    Akemi L Kawaguchi
    Department of Pediatric Surgery, Mass General Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA
    J Pediatr Surg 40:158-64; discussion 164-5. 2005
    ..The 2 most severe forms of LTEC are type III, with extension of the cleft from the larynx to the carina, and type IV, with extension of the cleft into one or both mainstem bronchi.
  101. ncbi Model for experimental revascularized laryngeal allotransplantation
    M A Birchall
    Department of Otolaryngology, University of Bristol, Bristol, UK
    Br J Surg 89:1470-5. 2002
    ..Although a human laryngeal transplant has been undertaken successfully, important questions remain that require a suitable animal model...

Research Grants65

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..serious airway complications that arise from subglottic stenosis (SGS), the most common acquired anomaly of the larynx in children and the most common abnormality requiring tracheotomy in infants...
  3. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..with tobacco and alcohol use, in the etiology of squamous cell carcinomas of the oral cavity, pharynx, and larynx (SCCHN), expanding our findings of a novel apoptosis mechanism that has not been described before...
  4. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..from a variety of sites in the upper aerodigestive tract (UADT), including the oral cavity, the pharynx, and the larynx. HNC represents the fifth most common malignancy worldwide...
  5. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..but locally warming the medulla in the region of the nucleus of the solitary tract (NTS), where afferents from the larynx make their synaptic connections with neurons that control breathing and swallowing, reversibly exaggerates the LCR,..
  6. "Gdf6 gene expression and evolution in vertebrates"
    Douglas Mortlock; Fiscal Year: 2009
    ..In mouse, Gdf6 is important for normal development of limb, ear, skull and spine skeletal joints, the larynx, and potentially other structures including the heart...
  7. Response of aging intrinsic laryngeal muscles to chronic electrical stimulation
    Colleen A McMullen; Fiscal Year: 2013
    ..The larynx is part of a complex sensorimotor system that serves as both a vibratory source for phonation and as a regulatory ..
  8. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2013
    ..as p53 mutations and HPV infections, in the etiology of squamous cell carcinomas of the oral cavity, pharynx, and larynx (SCCHN), expanding our findings of a novel apoptosis mechanism that has not been described before...
  9. PASSY-MUIR SWALLOWING SELF TRAINING DEVICE TO ENCHANCE RECOVERY POST STROKE
    CHRISTY LESLIE LUDLOW; Fiscal Year: 2012
    ..The vibration to the cartilage penetrates through the tissues to stimulate sensory receptors in the larynx -well known to trigger swallowing at the brain stem level...
  10. Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
    TIRUNELVELI RAMALINGAM; Fiscal Year: 2013
    ..clinically important structural information on suspect lesions, potential biopsy sites, and cancer margins of larynx in the office without the need for general anesthesia or sedation...
  11. Identification of Biomechanically Valid Cell Therapeutics for Vocal Fold Scar
    Rebecca S Bartlett; Fiscal Year: 2013
    ..of vocal fold scar have been performed in animal models which are not biomechanically translatable to the human larynx. The objective of this application is to determine if MSC (BM and/or AT) are biomechanically valid cell sources ..
  12. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..and structural roles, including the support of soft tissue (ear and nose), airway patency (trachea), phonation (larynx), and joint movement (i.e.,TMJ)...
  13. In Vivo Measures of Vocal Function Response to Environmental Conditions
    MARY JOYCE SANDAGE; Fiscal Year: 2012
    ..the interdependent relationship of environmental temperature and humidity on tissues within the voice box (larynx)...
  14. Exogenous growth factors for reversal of age-related laryngeal muscle denervation
    Joseph Stemple; Fiscal Year: 2011
    ..The larynx is part of a complex motor system that serves as a vibratory source of phonation and as a regulator that separates ..
  15. Bilayered Vocal Fold Tissue Engineering
    Jennifer L Long; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Veterans suffering loss of the larynx's vocal fold cover due to trauma or laryngeal cancer can suffer disabling voice difficulties, and treatment options are limited...
  16. The Effects of Hyper and Hypocapnia on Phonatory Laryngeal Resistance
    Amanda I Gillespie; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The larynx has a challenging dual role in the simultaneous regulation of breathing for blood-gas homeostasis and voice production for communication...
  17. Molecular mechanisms of aging in the intrinsic laryngeal muscles
    Colleen McMullen; Fiscal Year: 2009
    ..The larynx is part of a complex motor system that serves dually as the vibratory source of phonation and as a valve that ..
  18. Does Intensive Voice Therapy Improve Airway Protection in Parkinsons Disease
    MICHAEL J HAMMER; Fiscal Year: 2012
    ..This aim is highly innovative, clinically relevant, and will directly assess the ability of the larynx to detect and respond to a sensory stimulus...
  19. Lingual and Laryngeal Muscle Plasticity
    NADINE PATTAKOS CONNOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skeletal muscles, including those of the tongue and larynx, are capable of considerable plasticity based on changing demands and levels of activity...
  20. Genetic Susceptibility to Papilloma-induced Voice Disturbance
    FARREL JOEL BUCHINSKY; Fiscal Year: 2012
    ..the condylomatous viral types from their mothers, the infection produces the commonest benign neoplasm of the larynx, recurrent respiratory papillomatosis (RRP)...
  21. Mucosal Immune and Bacterial Characterization in Chronic Laryngitis
    Susan L Thibeault; Fiscal Year: 2013
    The larynx is a strategically important organ situated at the crossroads of the upper respiratory and digestive tracts, orchestrating swallowing, breathing, coughing and, in humans, voice...
  22. Aerodynamic Study for Laryngeal Function Assessment Using Airflow Interruption Me
    Jack J Jiang; Fiscal Year: 2013
    ..The multi-factorial nature of voice disorders necessitates that clinicians understand how the larynx functions in order to make appropriate treatment decisions...
  23. EGFR-targeted Polymeric Micelles for Targeted Pc 4-PDT of Oropharyngeal Tumors
    ALYSSA MANECK MASTER; Fiscal Year: 2013
    ..Cancers of the buccal cavity, head and neck subset, larynx, pharynx, and nose/nasal passages is the seventh most common cause of cancer death in the US...
  24. Roles of hedgehog signaling in foregut development
    JOHN A KLINGENSMITH; Fiscal Year: 2013
    ..The rostral endodermal foregut tube divides into ventral respiratory (larynx and trachea) and dorsal alimentary (esophagus and stomach) components...
  25. Guiding Mothers to Co-Regulate Oral Feeding with Very Preterm Infants
    Suzanne M Thoyre; Fiscal Year: 2012
    ..component of the intervention is use of the audio trainer(c), a small microphone placed over the infant's larynx to sensitize the mother to the infant's breathing and swallowing rhythms...
  26. Pathophysiology of Spasmodic Dysphonia: a TMS study
    Teresa Jacobson Kimberley; Fiscal Year: 2013
    ..conduction latency and intracortical excitation and inhibition associated with the corticobulbar control of the larynx in healthy people and people with SD...
  27. Glottal Physiology and Gender Perception of Transgender Speakers
    Adrienne B Hancock; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This study will illuminate the capabilities of the human larynx and inform the relationship between voice production and perception...
  28. Mechanism of chemopreventive synergism from the combination of EGCG and Erlotinib
    A R M Ruhul Amin; Fiscal Year: 2013
    ..at high risk of developing invasive cancer in tobacco carcinogen-exposed fields - especially the oral cavity and larynx. These cancers generally begin as small, often unnoticed, lesions inside the mouth and more than one third of ..
  29. Neuromuscular control of the larynx
    DINESH KHATRI CHHETRI; Fiscal Year: 2013
    ..inputs will be studied systematically with respect to all five intrinsic laryngeal muscles on either side of the larynx (cricothyroid [CT], thyroarytenoid [TA], lateral cricoarytenoid [LCA], interarytenoid [IA], and posterior ..
  30. Communicative Participation in Head and Neck Cancer
    Tanya L Eadie; Fiscal Year: 2010
    ..Fifteen individuals treated for HNCa (oral, oropharynx, hypopharynx, larynx) then will examine items within the bank using cognitive interviewing techniques...
  31. Prevention of Depression in Patients Being Treated for Head and Neck Cancer
    William J Burke; Fiscal Year: 2010
    ..Depression can also lead to suicide;patients with cancers of the larynx and tongue account for 2 of the 3 highest suicide rates in cancer patients...
  32. SELECTIVE ADDUCTOR RECOVERY AFTER LARYNGEAL NERVE INJURY
    Randal C Paniello; Fiscal Year: 2013
    ..3 (NT-3), is known to favor regeneration of fast-twitch fibers such as those found in the adductor muscles of the larynx. In this study, NT-3 will be tested using this new delivery system, for its effects on nerve regeneration, using a ..
  33. Adjustable balloon implant for medialization thyroplasty
    Matthew R Hoffman; Fiscal Year: 2012
    ..A silicone balloon which can be filled with saline is introduced into the larynx via a standard thyroplasty window and stabilized with a metal frame that prevents implant extrusion and ensures ..
  34. Design, construction, and evaluation of implants for vocal fold alteration and re
    Luc Mongeau; Fiscal Year: 2012
    ..Synthetic models of the larynx will be perfected and used for fundamental studies, as well as test beds for new implants...
  35. Exploring Cigarette Dependence among African-American Males in Barbershops.
    Alton Hart; Fiscal Year: 2010
    ..men have the highest incidence and death rates from oral/pharynx, pancreatic, esophageal, and lung larynx cancers...
  36. Source-Filter Interaction in Speech
    Ingo R Titze; Fiscal Year: 2013
    ..in speech production research, primarily with computer simulation, have shown that the primary sound source in the larynx (glottal airflow) can be highly influenced by acoustic pressures propagating backwards from the vocal tract to the ..
  37. Laryngeal muscular control of voice production and quality
    Zhaoyan Zhang; Fiscal Year: 2013
    ..This deficiency of understanding is largely due to the lack of an appropriate neuromuscular larynx model for conducting such systematic and quantitative investigations...
  38. PDT - Mechanisms and Strategies for Optimization
    Barbara W Henderson; Fiscal Year: 2013
    ..photosensitize HPPH equal or superior to porfimer sodium PDT in controlling early cancer of the oral cavity and larynx, while sparing patients protracted sun avoidance? Can biomarkers be identified that correlate with treatment ..
  39. Characterization of immune response in vocal fold injury and tissue regeneration
    Suzanne King; Fiscal Year: 2013
    ..progress for vocal fold scarring is hindered by our limited understanding of the immunological architecture of the larynx, specifically the role of macrophages and their response to inflammation. Injuries to the vocal fold (i.e...
  40. Influence of subglottic anatomy on voice production
    Scott L Thomson; Fiscal Year: 2013
    ..This will result from pursuit of the following specific aims: Aim 1: Quantify three-dimensional adult human larynx geometry for use in voice production research...
  41. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..However, based on experience studying the human larynx, a systematic approach is proposed with a variety of techniques that have all been successfully tested in the ..
  42. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2001
    ..However, based on experience studying the human larynx, a systematic approach is proposed with a variety of techniques that have all been successfully tested in the ..
  43. Modulation of the Voice Related to Tremor and Vibrato
    ROSEMARY ANNE LESTER; Fiscal Year: 2013
    ..e., pressure supply), the larynx (i.e. sound source), and the vocal tract (i.e., sound filter)...
  44. Mechanisms of Swallow Control of Breathing
    KENDALL FRANCIS MORRIS; Fiscal Year: 2013
    ..must reconfigure the respiratory neural network because many of the muscles used for control of the pharynx and larynx during breathing are also used during swallow...
  45. Cancer In the Jerusalem Perinatal Study
    Susan Harlap; Fiscal Year: 2005
    ..Preeclampsia was a risk factor for cancers of breast, ovary, stomach, lung/larynx and kidney in mothers, as well as for cardiovascular mortality...
  46. Dynamic Vocal Fold Abduction for Bilateral Paralysis
    Michael Broniatowski; Fiscal Year: 2006
    ..by applicant): Bilateral vocal cord paralysis is a life threatening condition due to the inability of the larynx (voice box) to open during inspiration...
  47. Effects of Swallowing Therapy in Head and Neck Cancer
    Jerilyn Logemann; Fiscal Year: 2006
    ..head and neck cancer often results in significant swallowing problems because of reduced range of motion of the larynx, tongue base and pharyngeal walls...
  48. AN ECM SCAFFOLD FOR HEAD AND NECK REPAIR
    Alan Spievack; Fiscal Year: 2001
    ..The surgical repair/reconstruction of head and neck structures such as the palate, tongue, nose and orbit, larynx, pharynx, and facial skin structures presently involves the use of complicated autograft procedures, mechanical ..
  49. PHYSIOLOGY AND MEASUREMENT OF VOCAL FOLD VIBRATION
    Jack Jiang; Fiscal Year: 2000
    ..An excised larynx model will be used to simulate abnormal vocal fold mechanical properties such as stiffness, tension, variations in ..
  50. Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma
    Norma Nowak; Fiscal Year: 2009
    ..500,000 new cases of head and neck squamous cell carcinoma (HNSCC), including the oral cavity, pharynx and larynx, are reported each year...
  51. Mechanisms for producing complex sounds
    Franz Goller; Fiscal Year: 2013
    ..The "electronic syrinx" will provide an excellent test device for developing a similar system for the human larynx.
  52. COORDINATION OF RESPIRATION AND DEGLUTITION
    ADRIENNE PERLMAN; Fiscal Year: 2003
    The close proximity of the larynx to the entrance of the esophagus, and the common pathway through the pharynx that both air and a swallowed bolus must traverse, require that swallowing and respiration be well coordinated...
  53. Improving Cancer Outcomes for African-Americans
    Patrick Maguire; Fiscal Year: 2007
    ..have higher mortality rates, compared with whites, for cancers of the uterine cervix, lung and bronchus, prostate, larynx, oral cavity and pharynx, breast, colon and rectum, and soft tissue...
  54. NATIONAL CENTER FOR VOICE AND SPEECH
    Ingo Titze; Fiscal Year: 1999
    ..projects are proposed in molecular biology, neurophysiology, biomechanics, acoustics, and motor control of the larynx and the upper airway structures...
  55. PARENT ASSISTED SMOKING CESSATION
    Nancy Murray; Fiscal Year: 2000
    ..continue to begin smoking, putting them at risk for an epidemic of diseases, including cancers of the lung, larynx, oral cavity, as well as COPD, CHD and stroke...
  56. Evaluating Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
    Jon Ebbert; Fiscal Year: 2009
    ..ST is known to increase the risk for cancer of the mouth and gum, larynx, and salivary gland...
  57. Neuromotor Modeling of Adductor Spasmodic Dysphonia
    Rick Roark; Fiscal Year: 2009
    ..requires the coordinated control of multiple muscles by the central nervous system, from diaphragm to lips - with larynx playing a principal role in the phonatory process...
  58. FUNCTION AND CONTROL OF THE LARYNX IN THE NEONATE
    Alastair Hutchison; Fiscal Year: 1991
    ....
  59. QUANTIFICATION OF IRREGULAR VOCAL FOLD OSCILLATIONS
    David Berry; Fiscal Year: 2001
    ..of irregular oscillations will be accomplished with the aid of multiple-camera high-speed video imaging and excise larynx experiments...
  60. TRACE ELEMENTS & CANCERS OF THE LARYNX/ESOPHAGUS & MOUTH
    David Thomas; Fiscal Year: 1991
    ..detailed analyses of somewhat greater power than the analyses of data on squamous carcinomas of the esophagus or larynx (which is adequate to assess the etiologic role of all major variables of interest)...
  61. LARYNGEAL ENDOSCOPE WITH CALIBRATED SIZING FUNCTION
    David Rosen; Fiscal Year: 2001
    ..Abstract): Laryngeal videoendoscopy combined with stroboscopy is now a mainstay for clinically assessing how the larynx functions to produce voice...
  62. Voice-preserved therapy of laryngeal papilloma in children
    Zhi Wang; Fiscal Year: 2009
    ..This disease usually involves the vocal cords or other regions of the larynx, thereby, resulting in a poor voice...
  63. Voice-preserving Treatment of Larynegeal Papilloma
    Zhi Wang; Fiscal Year: 2006
    ..This disease usually involves the vocal cords or other regions of the larynx, thereby, resulting in a poor voice...
  64. Inflammation and Fibrosis of the Vocal Folds
    RYAN COMFORT BRANSKI; Fiscal Year: 2011
    ..In the larynx, our laboratory and others have reported upregulation of COX-2 and PGE2 in vocal fold injury and we now seek to ..
  65. Proteomic analysis of head & neck squamous cell cancer
    Michael Prystowsky; Fiscal Year: 2005
    ..constitute an anatomically heterogeneous group of neoplasms arising from the oral cavity, oropharynx, hypopharynx, larynx and nasopharynx...