respiratory system

Summary

Summary: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

Top Publications

  1. pmc Topographical continuity of bacterial populations in the healthy human respiratory tract
    Emily S Charlson
    University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 184:957-63. 2011
  2. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
  3. pmc Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
  4. pmc Reassessment of the evidence for postcranial skeletal pneumaticity in Triassic archosaurs, and the early evolution of the avian respiratory system
    Richard J Butler
    GeoBio Center, Ludwig Maximilians Universitat Munchen, Munich, Germany
    PLoS ONE 7:e34094. 2012
  5. pmc Deep sequencing analyses of low density microbial communities: working at the boundary of accurate microbiota detection
    Giske Biesbroek
    Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32942. 2012
  6. ncbi The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
    Bart N Lambrecht
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
    Lancet 376:835-43. 2010
  7. pmc TRPA1 is a major oxidant sensor in murine airway sensory neurons
    Bret F Bessac
    Department of Pharmacology and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 118:1899-910. 2008
  8. ncbi Branching morphogenesis of the Drosophila tracheal system
    Amin Ghabrial
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Annu Rev Cell Dev Biol 19:623-47. 2003
  9. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
  10. ncbi Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa
    Vanja Klepac-Ceraj
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Environ Microbiol 12:1293-303. 2010

Detail Information

Publications287 found, 100 shown here

  1. pmc Topographical continuity of bacterial populations in the healthy human respiratory tract
    Emily S Charlson
    University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 184:957-63. 2011
    ..However, studies of the lung are challenging due to difficulties in working with low biomass samples...
  2. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
    ..The PVA in human respiratory tract most closely mirrored that in ferrets and pigs for human influenza viruses and that in ferrets, pigs, and cats for avian influenza viruses...
  3. pmc Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
    ..We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures...
  4. pmc Reassessment of the evidence for postcranial skeletal pneumaticity in Triassic archosaurs, and the early evolution of the avian respiratory system
    Richard J Butler
    GeoBio Center, Ludwig Maximilians Universitat Munchen, Munich, Germany
    PLoS ONE 7:e34094. 2012
    ....
  5. pmc Deep sequencing analyses of low density microbial communities: working at the boundary of accurate microbiota detection
    Giske Biesbroek
    Department of Pediatric Infectious Diseases and Immunity UMC Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e32942. 2012
    ..This study was aiming to establish protocols for accurate microbiota analysis at low microbial density...
  6. ncbi The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
    Bart N Lambrecht
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
    Lancet 376:835-43. 2010
    ....
  7. pmc TRPA1 is a major oxidant sensor in murine airway sensory neurons
    Bret F Bessac
    Department of Pharmacology and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 118:1899-910. 2008
    ..Our results indicate that TRPA1 is an oxidant sensor in sensory neurons, initiating neuronal excitation and subsequent physiological responses in vitro and in vivo...
  8. ncbi Branching morphogenesis of the Drosophila tracheal system
    Amin Ghabrial
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Annu Rev Cell Dev Biol 19:623-47. 2003
    ....
  9. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    ....
  10. ncbi Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa
    Vanja Klepac-Ceraj
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Environ Microbiol 12:1293-303. 2010
    ..aeruginosa, regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study...
  11. ncbi Airway smooth muscle cell proliferation is increased in asthma
    P R Johnson
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 164:474-7. 2001
    ..05). This study shows for the first time that proliferation of ASM cells is increased in patients with asthma and provides evidence for an intrinsic abnormality in the ASM cell in this disease...
  12. ncbi The polymicrobial nature of airway infections in cystic fibrosis: Cangene Gold Medal Lecture
    Christopher D Sibley
    Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Can J Microbiol 57:69-77. 2011
    ..The microbiology of CF airways may serve as a model to investigate the emergent properties of other clinically relevant microbial communities in the human body...
  13. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
    ..These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease...
  14. ncbi Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience
    Franziska Anne Stressmann
    Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Science, King s College London, 150 Stamford Street, Franklin Wilkins Building, London SE1 9NH, UK
    Thorax 67:867-73. 2012
    ..However, little is known about their clinical significance or persistence in CF airways...
  15. pmc The guinea pig as a transmission model for human influenza viruses
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:9988-92. 2006
    ..Our results demonstrate that influenza virus can pass between guinea pigs by means of droplet spread and thereby establish the suitability of the guinea pig as a model host for influenza virus transmission studies...
  16. pmc Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract
    Michael C W Chan
    Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Pathol 176:1828-40. 2010
    ..These findings are therefore relevant for understanding transmission and therapy...
  17. pmc Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry
    Whitney W Stevens
    The Carter Immunology Center, UVa Health Sciences Center, Charlottesville, VA 22908, United States
    J Immunol Methods 327:63-74. 2007
    ..Furthermore, this flow cytometry-based method can be directly adapted to enumerate eosinophils infiltrating the inflamed lung parenchyma, thereby obviating the need for quantitative morphometry of tissue sections...
  18. ncbi Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    ..These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences...
  19. ncbi A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
  20. ncbi Avian influenza receptor expression in H5N1-infected and noninfected human tissues
    Lu Yao
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University, 38 Xueyuan Rd, 100083 Beijing, China
    FASEB J 22:733-40. 2008
    ..Finally, the relative lack of AIV-Rs in the upper airway may be a one of the factors preventing efficient human-to-human transmission of H5N1 influenza...
  21. pmc Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections
    Robert Tarran
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 280:35751-9. 2005
    ....
  22. ncbi Nitric oxide in health and disease of the respiratory system
    Fabio L M Ricciardolo
    Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Physiol Rev 84:731-65. 2004
    ....
  23. pmc High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI)
    David W Parsons
    Department of Pulmonary Medicine, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia
    J Anat 213:217-27. 2008
    ..The coupling of phase-contrast synchrotron X-ray imaging technology with software-based reconstruction techniques holds promise for novel and high-resolution non-invasive examination of airspace anatomy in small animal models...
  24. pmc Risks from accidental exposures to engineered nanoparticles and neurological health effects: a critical review
    Myrtill Simko
    Austrian Academy of Sciences, Institute of Technology Assessment, Vienna, Austria
    Part Fibre Toxicol 7:42. 2010
    ..Crucial deficits include lack of exposure data, the absence of a proper dose concept, and that studies often fail in adequate description of the investigated ENPs...
  25. pmc Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways
    Arjun Guha
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 109:12592-7. 2012
    ....
  26. ncbi Effect of airway opening on production of exhaled particles
    Ann Charlotte Almstrand
    Occupational and Environmental Medicine at Sahlgrenska Academy, Box 414, SE 405 30 Gothenburg, Sweden
    J Appl Physiol (1985) 108:584-8. 2010
    ..Our results show that airway reopening following airway closure is an important mechanism for formation of endogenous exhaled particles and that these particles originate from the terminal bronchioles...
  27. ncbi Cystic fibrosis: a disease of vulnerability to airway surface dehydration
    Richard C Boucher
    Cystic Fibrosis Pulmonary Research and Treatment Center and the UNC Virtual Lung Group, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Trends Mol Med 13:231-40. 2007
    ..Recent clinical studies indicate that inhalation of hypertonic saline osmotically draws sufficient water onto CF airway surfaces to provide clinical benefit...
  28. pmc Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome
    Bernard Lambermont
    Hemodynamic Research Center, HemoLiege, University of Liege, Belgium
    Crit Care 12:R91. 2008
    ....
  29. ncbi Targeted cell replacement with bone marrow cells for airway epithelial regeneration
    Amy P Wong
    Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto Lung Transplant Program, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L740-52. 2007
    ..Some BMC cultured in vitro over time also expressed GFP transgene, suggesting epithelial transdifferentiation of the BMC. The results indicate that targeted delivery of BMC can promote airway regeneration...
  30. pmc Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs
    Sharon M Brookes
    Veterinary Laboratories Agency Weybridge, EU OIE FAO Reference Laboratory for Avian Influenza and Newcastle Disease, Addlestone, Surrey, United Kingdom
    PLoS ONE 5:e9068. 2010
    ..These findings provide potential clues to the existence and biological significance of viral receptor-binding variants with 225D and 225G during the 1918 pandemic [5]...
  31. ncbi Time course of endotoxin-induced airways' inflammation in healthy subjects
    Virginie Doyen
    Clinics of Immuno allergology, CHU Brugmann, Universite Libre de Bruxelles ULB, pl Van Gehuchten, 4, 1020, Brussels, Belgium
    Inflammation 35:33-8. 2012
    ..When repeated endotoxin inhalations are used as a model of inflammation, a wash-out period of at least 7 days should be applied between each exposure in each subject...
  32. pmc Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick children
    Melinda M Pettigrew
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:6262-70. 2012
    ..51; 95% CI, 0.31 to 0.83). An increased understanding of polymicrobial interactions will facilitate the development of effective AOM prevention strategies...
  33. pmc Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases
    Belaid Bouazza
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 47:464-73. 2012
    ..We propose that the novel mechanism that proasthmatic cytokine-induced CSI in ASMCs is due, in part, to PP5-mediated impairment of GR-Ser211 phosphorylation...
  34. ncbi Pulmonary pneumaticity in the postcranial skeleton of extant aves: a case study examining Anseriformes
    Patrick M O'Connor
    Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
    J Morphol 261:141-61. 2004
    ..Finally, enigmatic pneumatic features located in distal forelimb elements of screamers (Anhimidae) result from invasion of bone by a network of subcutaneous air sac diverticula spreading distally along the wings...
  35. pmc Oral and airway microbiota in HIV-infected pneumonia patients
    Shoko Iwai
    University of California San Francisco, San Francisco, California, USA
    J Clin Microbiol 50:2995-3002. 2012
    ....
  36. ncbi Well-differentiated human airway epithelial cell cultures
    M Leslie Fulcher
    Cystic Fibrosis, Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, NC, USA
    Methods Mol Med 107:183-206. 2005
  37. ncbi Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule
    D J Thornton
    The Wellcome Trust Centre for Cell Matrix Research, University of Manchester, 2 205, Stopford Building, Manchester M139PT, United Kingdom
    J Biol Chem 272:9561-6. 1997
    ....
  38. ncbi Interleukin-17 and airway remodelling
    Anders Linden
    Department of Medicine, Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Parkville, Vic, Australia
    Pulm Pharmacol Ther 19:47-50. 2006
    ..If this is the case, then IL-17A may constitute a useful target for pharmacotherapeutic intervention in allergic airway disease...
  39. ncbi Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006
    ..As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence...
  40. ncbi Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo
    Kim L Roberts
    Department of Virology, Imperial College London, St Mary s Campus, London W2 1PG, UK
    J Gen Virol 92:1822-31. 2011
    ....
  41. ncbi Multidetector computed tomography (MDCT) for preoperative airway assessment in children with mucopolysaccharidoses
    P M Ingelmo
    First Service of Anesthesia and Intensive Care, San Gerardo Hospital, Monza, Italy
    Minerva Anestesiol 77:774-80. 2011
    ..However, MDCT has not been recommended in MPS children. The aim of this clinical scenario study was to verify whether information from MDCT reconstruction of the airway is useful in airway management planning of children with MPS...
  42. ncbi Mucoactive agents for airway mucus hypersecretory diseases
    Duncan F Rogers
    Airway Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
    Respir Care 52:1176-93; discussion 1193-7. 2007
    ..It is noteworthy that, of the more complex molecules in development, it is simple inhaled hypertonic saline that is currently receiving the greatest attention as a mucus therapy, primarily in CF...
  43. pmc Segregation of virulent influenza A(H1N1) variants in the lower respiratory tract of critically ill patients during the 2010-2011 seasonal epidemic
    Antonio Piralla
    Struttura Semplice Virologia Molecolare, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    PLoS ONE 6:e28332. 2011
    ..Since its appearance in 2009, the pandemic influenza A(H1N1) virus circulated worldwide causing several severe infections...
  44. pmc The airway microbiota in cystic fibrosis: a complex fungal and bacterial community--implications for therapeutic management
    Laurence Delhaes
    Center for Infection and Immunity of Lille CIIL, Institut Pasteur de Lille, Biology and Diversity of Emerging Eukaryotic Pathogens BDEEP, BP 245, Lille, France
    PLoS ONE 7:e36313. 2012
    ..In this study, we developed a pyrosequencing approach to extensively explore the diversity and dynamics of fungal and prokaryotic populations in CF lower airways...
  45. ncbi The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells
    Ning Yang
    State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Tsinghua University, Chinese Academy of Medical Sciences, Beijing, China
    J Mol Cell Biol 3:221-9. 2011
    ..Therefore, we discovered that the 2009 pandemic H1N1 strain, A/Wenshan/01/2009, can induce apoptotic cell death in epithelial cells of the human respiratory tract, suggesting a molecular pathogenesis for the 2009 pandemic H1N1...
  46. pmc Avian influenza h6 viruses productively infect and cause illness in mice and ferrets
    Laura Gillim-Ross
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    J Virol 82:10854-63. 2008
    ..However, we have identified an H6 virus that induces protective immunity against viruses in the North American and Eurasian lineages...
  47. pmc Experimental infection of mice with avian paramyxovirus serotypes 1 to 9
    Sunil K Khattar
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 6:e16776. 2011
    ..Taken together, these results demonstrate that all APMV serotypes except APMV-5 are capable of replicating in mice with minimal disease and pathology...
  48. pmc Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1
    Mary E B Martino
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 284:14904-13. 2009
    ..These findings suggest that, in inflamed HBE, XBP-1s is responsible for the ER/Ca(2+) store expansion that confers amplification of Ca(2+)-dependent inflammatory responses...
  49. ncbi Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
    Amanda L Brennan
    Glucose and Pulmonary Infection Group, St George s, University of London, Room 66, Ground Floor Jenner Wing, Cardiac and Vascular Sciences Respiratory, Cranmer Terrace, SW17 0RE, London, United Kingdom
    J Cyst Fibros 6:101-9. 2007
    ..In people without CF, airway glucose (AG) concentrations are elevated when blood glucose (BG)> or =8 mmol L(-1) (airway threshold), and are associated with acquisition of respiratory infection...
  50. ncbi Afferent neural pathways in cough and reflex bronchoconstriction
    J A Karlsson
    Pharmacological Laboratory, AB Draco, Lund, Sweden
    J Appl Physiol (1985) 65:1007-23. 1988
    ..Although cough and bronchoconstriction may be mediated by the same type of receptor, they seem to have separate afferent neural pathways...
  51. pmc Effect of aging on respiratory system physiology and immunology
    Gulshan Sharma
    Division of Allergy, Pulmonary, Immunology, Critical Care, and Sleep APICS, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0561, USA
    Clin Interv Aging 1:253-60. 2006
    ..of the elderly population of the US, a thorough understanding of "normal" aging-related changes on the respiratory system is paramount...
  52. pmc Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 83:7075-84. 2009
    ..These findings demonstrate that avian influenza viruses within H7 and H5 subtypes are capable of using the eye as a portal of entry...
  53. ncbi Influenza A virus receptors in the respiratory and intestinal tracts of pigeons
    Yuehuan Liu
    Institute of Animal and Husbandry Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, PR China
    Avian Pathol 38:263-6. 2009
    ..Overall, the results suggest that SAalpha2,6Gal is the major receptor in the pigeon airway, which may partly contribute to the resistance of pigeons to Asian lineage HPAIV subtype H5N1...
  54. ncbi Physiological changes in respiratory function associated with ageing
    J P Janssens
    Dept of Geriatrics, Geneva University Hospital, Switzerland
    Eur Respir J 13:197-205. 1999
    ..In spite of these changes, the respiratory system remains capable of maintaining adequate gas exchange at rest and during exertion during the entire lifespan, ..
  55. ncbi Airway epithelial cell signaling in response to bacterial pathogens
    Marisa I Gomez
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Pediatr Pulmonol 43:11-9. 2008
    ..The major signaling cascades initiated by epithelial receptors that lead to phagocyte recruitment to the airways as well as the ability of the epithelium to regulate inflammation are discussed...
  56. pmc Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels
    Thomas E Taylor-Clark
    Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD, USA
    J Physiol 588:423-33. 2010
    ..Thus, ozone is not an indiscriminate neuronal activator, but rather it potently and selectively activates a subset of airway C-fibres by directly stimulating TRPA1...
  57. ncbi Respiratory microbiology of patients with cystic fibrosis in the United States, 1995 to 2005
    Samiya Razvi
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Chest 136:1554-60. 2009
    ..Numerous improvements in diagnostic and therapeutic strategies for patients with cystic fibrosis (CF) have occurred during the past 2 decades. We hypothesized that these changes could impact trends in respiratory microbiology...
  58. ncbi Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses
    G Harata
    Technical Research Laboratory, Takanashi Milk Products Co, Ltd, Yokohama, Kanagawa, Japan
    Lett Appl Microbiol 50:597-602. 2010
    ..To investigate whether intranasal Lactobacillus administration protects host animals from influenza virus (IFV) infection by enhancing respiratory immune responses in a mouse model...
  59. ncbi Modulation of dendritic cell trafficking to and from the airways
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Immunol 176:3578-84. 2006
    ....
  60. ncbi The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?
    Scott Wagers
    Vermont Lung Center, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Appl Physiol (1985) 96:2019-27. 2004
    ..This has implications for the pathophysiology of asthma and suggests that at least some types of asthma may benefit from therapies aimed at manipulating surface tension at the air-liquid interface in the lungs...
  61. pmc Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 195:221-31. 2002
    ..The induction of Tr1 cells after interaction of a pathogen-derived molecule with cells of the innate immune system represents a novel strategy exploited by an infectious pathogen to subvert protective immune responses in vivo...
  62. pmc The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice
    Michelle D Tate
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
    Respir Res 9:57. 2008
    ....
  63. ncbi Vagal afferent nerves regulating the cough reflex
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 152:223-42. 2006
    ..Whether these "cough receptors" are the guinea pig equivalent of the irritant receptors described in the extrapulmonary airways of other species is unclear...
  64. ncbi Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
    Am J Physiol Lung Cell Mol Physiol 291:L208-21. 2006
    ....
  65. pmc Comparative in vitro study of interactions between particles and respiratory surface macrophages, erythrocytes, and epithelial cells of the chicken and the rat
    S G Kiama
    Department of Veterinary Anatomy and Physiology, University of Nairobi, P O Box 30197, Nairobi, Kenya
    J Anat 213:452-63. 2008
    In mammals, surface macrophages (SMs) play a foremost role in protecting the respiratory system by engulfing and destroying inhaled pathogens and harmful particulates...
  66. ncbi Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism
    Peter R A Johnson
    Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    J Allergy Clin Immunol 113:690-6. 2004
    ..We have previously shown that nonasthmatic ASM cells in culture produce a range of extracellular matrix protein proteins and that asthmatic ASM cells proliferate faster than cells from nonasthmatic patients...
  67. pmc No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation
    Steven C Gribar
    Division of Pediatric Surgery, Department of Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Med 14:645-59. 2008
    ..Recent work in support of these concepts is extensively reviewed, while essential areas of further study that are required to determine the significance of epithelial TLR signaling during states of health and disease are outlined...
  68. pmc Expression patterns of influenza virus receptors in the respiratory tracts of four species of poultry
    Ji Eun Yu
    Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 143 701, Korea
    J Vet Sci 12:7-13. 2011
    ..These results indicate that pheasants and quails may play important roles as intermediate hosts for the generation of influenza viruses with pandemic potential...
  69. pmc Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9
    Arthur S Samuel
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    Vet Res 42:38. 2011
    ..Taken together, these results demonstrate that all nine known APMV serotypes are capable of replicating in hamsters with minimal disease and pathology...
  70. ncbi Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthma
    Shailaja G Mahajan
    Department of Pharmacology, L M College of Pharmacy, Ahmedabad, Gujarat, India
    Eur J Pharmacol 650:458-64. 2011
    ..sitosterol possesses anti-asthmatic actions that might be mediated by inhibiting the cellular responses and subsequent release/synthesis of Th2 cytokines. This compound may have therapeutic potential in allergic asthma...
  71. pmc Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells
    James P Garnett
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 286:41069-82. 2011
    ....
  72. ncbi Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace
    Bradley F Marple
    Department of Otolaryngology Head and Neck Surgery, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390 9035, USA
    Am J Rhinol Allergy 24:249-54. 2010
    ....
  73. ncbi Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets
    Isabelle Meunier
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Virology 422:125-31. 2012
    ..This virus was also associated with a rapid and sustained induction of inflammatory cytokines, indicating that early dysregulation of the host response contributes importantly to the disease outcome...
  74. pmc Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract
    Aliete Langsdorf
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    Am J Respir Cell Mol Biol 44:293-301. 2011
    ....
  75. ncbi Local innate immune responses and influenza virus transmission and virulence in ferrets
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 205:474-85. 2012
    ..Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression...
  76. pmc Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures
    Krzysztof Pyrc
    Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    J Virol 84:11255-63. 2010
    ....
  77. pmc Influenza A and B virus attachment to respiratory tract in marine mammals
    Antonio J Ramis
    Universitat Autonoma de Barcelona, Barcelona, Spain
    Emerg Infect Dis 18:817-20. 2012
    ..Attachment of avian influenza A viruses (H4N5) and (H7N7) and human influenza B viruses to trachea and bronchi of harbor seals is consistent with reported influenza outbreaks in this species...
  78. pmc Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients
    J Kuypers
    University of Washington, Seattle, Washington, USA
    Transpl Infect Dis 11:298-303. 2009
    ..To evaluate the relative sensitivity of respiratory virus detection in specimens from HCT recipients, we compared the results of conventional and quantitative molecular methods...
  79. pmc Enhanced viral etiological diagnosis of respiratory system infection outbreaks by use of a multitarget nucleic acid amplification assay
    Sallene Wong
    Provincial Laboratory for Public Health Microbiology, 3030 Hospital Drive NW, Calgary, Alberta T2N 4W4, Canada
    J Clin Microbiol 47:3839-45. 2009
    ..8% of outbreaks using a combination of DFA, NATs, and RVP. Use of RVP enhances the laboratory investigation of respiratory virus outbreaks and facilitates appropriate patient and outbreak management...
  80. pmc Antimicrobial polypeptides in host defense of the respiratory tract
    Tomas Ganz
    University of California Los Angeles School of Medicine, Center for the Health Sciences, 10833 LeConte Avenue, 37 055, Los Angeles, CA 90095 1690, USA
    J Clin Invest 109:693-7. 2002
  81. ncbi Heterosubtypic immunity to influenza A virus in mice lacking IgA, all Ig, NKT cells, or gamma delta T cells
    K A Benton
    Molecular Immunology Laboratory, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA
    J Immunol 166:7437-45. 2001
    ....
  82. pmc Transient receptor potential A1 channels: insights into cough and airway inflammatory disease
    Maria G Belvisi
    Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, and the Centre for Integrative Physiology and Pharmacology, Faculty of Medicine, Imperial College London, London, England
    Chest 140:1040-7. 2011
    ....
  83. ncbi Detection and quantification of human metapneumovirus in pediatric specimens by real-time RT-PCR
    Jane Kuypers
    Department of Laboratory Medicine, University of Washington, CHRMC, 4800 Sand Point Way N E, Virology Office, G 815, 8G 3, Seattle, WA 98105, USA
    J Clin Virol 33:299-305. 2005
    ..Human metapneumovirus (h MPV), a recently identified virus, causes respiratory illness in children...
  84. pmc G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma
    Gustavo Nino
    Division of Pulmonary Medicine, Children s Hospital of Philadelphia Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e32078. 2012
    ....
  85. pmc The impact of sugar cane-burning emissions on the respiratory system of children and the elderly
    José E D Cançado
    Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Environ Health Perspect 114:725-9. 2006
    We analyzed the influence of emissions from burning sugar cane on the respiratory system during almost 1 year in the city of Piracicaba in southeast Brazil...
  86. ncbi Symmorphosis and the insect respiratory system: allometric variation
    Edward P Snelling
    School of Earth and Environmental Sciences, University of Adelaide, South Australia 5005, Australia
    J Exp Biol 214:3225-37. 2011
    Taylor and Weibel's theory of symmorphosis predicts that structures of the respiratory system are matched to maximum functional requirements with minimal excess capacity...
  87. pmc Caveolin-1 regulation of store-operated Ca(2+) influx in human airway smooth muscle
    Venkatachalem Sathish
    Dept of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Eur Respir J 40:470-8. 2012
    ..These results demonstrate that caveolar expression and regulation of proteins such as Orai1 are important for [Ca(2+)](i) regulation in human ASM cells and its modulation during inflammation...
  88. pmc Respiratory evolution facilitated the origin of pterosaur flight and aerial gigantism
    Leon P A M Claessens
    Department of Biology, College of the Holy Cross, Worcester, MA, USA
    PLoS ONE 4:e4497. 2009
    ..present various lines of skeletal evidence that indicate that pterosaurs had a highly effective flow-through respiratory system, capable of sustaining powered flight, predating the appearance of an analogous breathing system in birds by ..
  89. ncbi Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 90:197-205. 2012
    ..Therefore, neutrophils are important participants in anti-viral mechanisms that sustain effective CD8(+) T-cell responses in the respiratory tract of influenza virus-infected mice...
  90. pmc Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study
    J Barenfanger
    Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781, USA
    J Clin Microbiol 38:2824-8. 2000
    ..Summarizing, the cytospin FA markedly decreased turnaround time and was associated with decreased mortality, length of stay, and costs and with better antibiotic stewardship...
  91. ncbi KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, Missouri
    David J Hormozdi
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatr Infect Dis J 29:329-33. 2010
    ..So far, evidence has not supported a link between infections with either virus and respiratory tract disease; however, there has not been a large comparison of KIPyV-infected patients to age-matched patient groups...
  92. pmc Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice
    T Hori
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 1868650, Japan
    Clin Diagn Lab Immunol 8:593-7. 2001
    ..These findings suggest that intranasal administration of LcS enhances cellular immunity in the respiratory tract and protects against influenza virus infection...
  93. ncbi Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006
  94. ncbi Acyl homoserine lactones induce early response in the airway
    Andrea Sbarbati
    Department of Morphological Biomedical Sciences, Section of Human Anatomy and Histology, University of Verona, Verona, Italy
    Anat Rec (Hoboken) 292:439-48. 2009
    ..Our results show that AHL action is not limited to activation of conspecific bacteria, but also modifies innate airway defense mechanisms...
  95. pmc Studying bacteria in respiratory specimens by using conventional and molecular microbiological approaches
    Geraint B Rogers
    King s College London, Molecular Microbiology Research Laboratory, Pharmaceutical Science Division, 150 Stamford Street, Franklin Wilkins Building, King s College London, London, SE1 9NH, UK
    BMC Pulm Med 9:14. 2009
    ..Here, the aim was to determine the extent to which routine diagnostic microbiology gave a different assessment of the species present in sputa when analysed by using culture-independent assessment...
  96. ncbi An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures
    Philip H Karp
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA
    Methods Mol Biol 188:115-37. 2002
  97. ncbi Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia
    D S Southam
    Asthma Research Group and Firestone Institute of Respiratory Health, Department of Medicine, McMaster University, 50 Charlton Avenue E, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L833-9. 2002
    ..When using intranasal instillation, the relative distribution between the URT and LRT and the gastrointestinal tract is heavily influenced by delivery volume and level of anesthesia...
  98. ncbi An alternative approach to the identification of respiratory central chemoreceptors in the brainstem
    C Jiang
    Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30302 4010, USA
    Respir Physiol 129:141-57. 2001
    ..1-Kir5.1 contributes to the CO(2)/pH sensitivity in these neurons. We believe that this line of research intended to identify CO(2) sensing molecules is an important addition to current studies on the CCRs...
  99. pmc Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
    Jason R Rock
    Department of Cell Biology, Nanaline Duke Building, Duke University Medical Center, Durham, NC 27710, USA
    Dis Model Mech 3:545-56. 2010
    ....
  100. ncbi The structure and function of carbonic anhydrase isozymes in the respiratory system of vertebrates
    A J Esbaugh
    Department of Biology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Respir Physiol Neurobiol 154:185-98. 2006
    ..This review will examine the structural characteristics that are integral to CAs participation in respiration, as well as highlight the specific roles and tissues that the different CA isozymes are involved in...
  101. ncbi Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system
    N Watanabe
    Sackler Institute of Pulmonary Pharmacology, Pharmaceutical Sciences Research Division, School of Biomedical and Health Sciences, King s College London, St Thomas Street, London SE1 1UL, UK
    Neuroscience 141:1533-43. 2006
    ....

Research Grants80

  1. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..We will use a murine model of allergic fungal rhinosinusitis with exacerbation by smoke or DEP exposure to determine the efficacy of antiMUC1-SOD/CAT-NPs. ..
  2. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..E.S.T (Breastfeeding, Education &Support Team) Alliance for Babies} and propose to conduct community participation research of breastfeeding disparities in African American women in Durham County, North Carolina. ..
  3. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..neurodegeneration;however, in addition to cancer, one of the leading causes of morbidity and mortality is respiratory system disease, including interstitial lung disease (ILD)...
  4. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..We propose to show its usefulness as a monitor of sleep in health, in those with simple and complicated forms of sleep apnea, and in patients with heart failure. ..
  5. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..This project will identify potential therapeutic targets and molecules that will provide the basis for future therapies of these chronic lung diseases that, together, comprise a major health problem world-wide. ..
  6. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  7. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    ..The ion transport properties of the upper and lower airways wil be determined, as these are reflective of the hydration status of the ASL. Tissue samples from mice 3, 6, 12, and 24 months old will be studied in Ussing chambers. ..
  8. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..Lung mechanics will be evaluated hourly, allowing for determination of: 1) dynamic respiratory system compliance, 2) resistance and hysteresivity derived from dynamic pressure volume loops, and 3) static ..
  9. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..abstract_text> ..
  10. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..abstract_text> ..
  11. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..Influenza infection kills over 35,000 people in the United States each year. These studies will provide new information to enhance our ability to improve the influenza vaccines. ..
  12. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    ....
  13. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..S. civilians could be adversely affected by highly toxic chemicals released intentionally in terrorist attacks or unintentionally in industrial accidents or natural disasters. ..
  14. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..Despite numerous studies examining the effects of petroleum diesel (petrodiesel) exhaust emissions on the respiratory system, the mechanisms responsible for the reported adverse human health effects and pinpointing the particulate&..
  15. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..laboratory and epidemiologic evidence to suggest that air pollution and URIs have interactive effects on the respiratory system. We have shown, in a prior epidemiologic study, that asthmatics with cold symptoms show more changes in lung ..
  16. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..This rod shaped bacterium infects humans through the respiratory system, skin, or digestive tract. Dependent upon the entry route into the human body, Anthrax can be highly lethal...
  17. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..There is a renewed enthusiasm for vaccines for otitis media given recent promising clinical trials, creating a momentum of feasibility for this approach. ..
  18. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ....
  19. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ....
  20. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ....
  21. High-throughput Screenings to Identify Host Receptors for Staphylococcal Adhesins
    Renata Pasqualini; Fiscal Year: 2012
    ..Our research aims to better understand staphylococcal infection and to set the grounds for targeted therapies against this disease. ..
  22. Prevention and therapy of Staphylococcus aureus infections
    Olaf Schneewind; Fiscal Year: 2010
    ..These technologies will be developed with the goal of generating a vaccine and immune therapeutics, thereby providing protection against S. aureus infections and improving global health. ..
  23. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..e. hearing loss due to OM), a goal of Strategic Plan Priority Area I. ..
  24. Bordetella Cyclase Toxin:Effect on Leukocytes and Respiratory Epithelial Cells
    Erik L Hewlett; Fiscal Year: 2013
    ....
  25. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ....
  26. Single RNA sensitive probes for studying viral replication and budding
    Philip J Santangelo; Fiscal Year: 2013
    ....
  27. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
    ..DBM will utilize a deep panel of immortalized human cells derived from skin (keratinocytes), respiratory system (nasal, airway and lung epithelial cells) and renal system (proximal tubule, cortical, and medullary kidney ..
  28. Biomarkers of Sudden Death and Progressive Heart Failure
    GORDON FRANK TOMASELLI; Fiscal Year: 2010
    ....
  29. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
  30. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..We wish to see if it can be spread from, or to, the lungs, like influenza or tuberculosis. If it can spread in this way, then we can prevent people from getting infected by actions such as wearing masks and washing hands after coughing. ..
  31. Function of mRNA Editing in Trypanosomes
    Stephen L Hajduk; Fiscal Year: 2010
    ..coding genes thus allowing the translation of edited mRNAs to produce components of the mitochondrial respiratory system. While this is certainly an important function for RNA editing we recently discovered that primary mRNAs are ..
  32. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..We will determine if passive vaccination with mAbs and active vaccination with recombinant BR constructs protects mice against pneumococcal challenge. ..
  33. H. influenzae: Role of Sialic Acid in Virulence
    Michael A Apicella; Fiscal Year: 2013
    ..Finally, studies of isolates from human subjects colonized with NTHi 2019strR will examine the role of phase variation on LOS structure and determine if foreign DNA is acquired by NTHi during colonization. ..
  34. Role of Staphylococcus aureus alpha-hemolysin in disease
    Juliane Bubeck Wardenburg; Fiscal Year: 2013
    ..These studies are expected to shed light on elements of host susceptibility to S. aureus disease, and contribute more broadly to our understanding of bacterial pore forming cytotoxins. ..
  35. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..influenzae disease. More generally, these studies will provide fundamental insights into host-microbial relationships, bacterial protein secretion, and prokaryotic protein glycosylation. ..
  36. Developmental Physiology of Ciliated Epithelia
    CHRISTOPHER ROBERT KINTNER; Fiscal Year: 2012
    ....
  37. Peptide inhbitors of influenza entry-FAST TRACK
    Russell B Wilson; Fiscal Year: 2011
    ....
  38. H. influenzae: Role of Sialic Acid in Virulence
    Michael Apicella; Fiscal Year: 2009
    ..abstract_text> ..
  39. MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCH
    MARK WALTER FRAMPTON; Fiscal Year: 2013
    ..Research by these young investigators will improve our understanding of how the respiratory system responds to injury and environmental challenges, and will improve public health by developing new and ..
  40. Perinatal Stress and programming of childhood wheeze and lung function
    Rosalind J Wright; Fiscal Year: 2013
    ..normal course of lung morphogenesis and maturation, potentially impacting both structure and function of the respiratory system. Moreover, when normal development is altered, the early effects may persist into adult life, magnifying the ..
  41. IL8-induced Post-transcriptional Regulation of the MUC5AC mucin gene
    Mary C Rose; Fiscal Year: 2010
    ..This will be fundamental for formulating therapeutic interventions for lung diseases that manifest with mucin overproduction. ..
  42. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..abstract_text> ..
  43. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..Understanding of the role of the innate immune and inflammatory response in children with life-threatening and fatal influenza infection could provide new targets for future preventive (immune adjuvant) and therapeutic approaches. ..
  44. Immune Regulation of Virus Clearance and Tissue Injury at Sites of Infection
    Thomas J Braciale; Fiscal Year: 2013
    ..To determine the impact of viral infection on the production of Te-derived IL- 10. The proposed studies are designed to complement ongoing related studies in Projects 2, 3 and 4. ..
  45. Transcriptional Control of Submucosal Gland Formation and Function
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..This proposal seeks to determine the cellular and molecular basis underlying AEC and SMG morphogenesis and function relevant to the pathogenesis of recurrent infections caused by defects in mucociliary clearance. ..
  46. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ....
  47. Pregnancy Folate Status &Early Childhood Respiratory &Atopic Disease Outcomes
    KECIA NICOLE CARROLL; Fiscal Year: 2013
    ..This study has potential to inform prenatal recommendations and identify modifiable risk factors for asthma and atopy. ..
  48. Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies
    RITA MARIE RYAN; Fiscal Year: 2013
    ..The future of many vulnerable children depends on this pioneering approach to the Prematurity and Respiratory Outcomes Program, PROP. ..
  49. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ....
  50. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..This treatment stimulates immunity against influenza virus, as well as interferes with the virus'ability to do damage to the airways. ..
  51. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2013
    ..This basic information will provide potential avenues for rational vaccine design that aims to boost local/mucosal immune responses. ..
  52. Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through Epige
    DAVID ALBERT SCHWARTZ; Fiscal Year: 2010
    ..Our research team proposes to determine if such concerns about methyl donor supplementation are justified and pose a real threat in expectant mothers already at risk for transmitting an atopic genetic predisposition to their infants. ..
  53. Point of care microfluidic diagnosis system for rapid and sensitive detection of
    Michel G Bergeron; Fiscal Year: 2013
    ..These POCTs will help public health authorities to define new operational strategies for both lab-based and field-based applications. ..
  54. Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. Influenzae
    Robert S Munson; Fiscal Year: 2013
    ..abstract_text> ..
  55. Yeast Based Assays for Chemical Screens Against SARS-CoV Targets
    DANIEL A contact ENGEL; Fiscal Year: 2010
    ..We hypothesize that we can learn about the biology of SARS-CoV by identifying which chemical compounds can inhibit it, and then study how they work. ..
  56. Bordetella Biofilms and Pathogenesis
    RAJENDAR K DEORA; Fiscal Year: 2011
    ..coli and Yersinia Spp, and possibly others, our results will contribute towards the treatment and the understanding of a wide variety of bacterial infections. ..
  57. Novel Biomarkers Predictive of Heparin-Induced Thrombocytopenia
    Barbara A Konkle; Fiscal Year: 2010
    ..This study will help identify patients most at risk of developing HIT with heparin therapy so that the approach to their care can be altered, and thus, improved. ..
  58. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..This proposal will determine if alveolar macrophages and mucosal epithelial cells, the primary point of contact for respiratory tract pathogens in the lungs, experience ADTD. ..
  59. Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
    Matthias Gromeier; Fiscal Year: 2010
    ..We are testing a new type of vaccine based on a common cold- causing virus targeting these pathways. We will evaluate our immunization technology in a novel animal model for the common cold. ..
  60. Hazard Assessment and Risk Estimation of Inhaled Nanomaterials Exposure
    Gunter Oberdorster; Fiscal Year: 2010
    ..These results will be used to develop and validate short-term tests that can be used for estimating potential human risk following ENM exposure. ..
  61. Ozone, apoE4, aging, and Alzheimer's disease
    Rui Ming Liu; Fiscal Year: 2013
    ..that O3 inhalation also causes oxidative stress and pathological changes in other tissues/organs beyond the respiratory system. Interestingly, it has been reported that children and young adults living in urban areas with high levels ..
  62. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    ..This information will provide novel approaches for therapeutic intervention of respiratory coronavirus infections and aid in the design of future coronavirus vaccines. ..
  63. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    ..Aims 3 and 4 to be completed in Year 2 within BSL-3 labs.] ..
  64. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ....
  65. Targeted Therapies for Selected Phenotypes of Obstructive Sleep Apnea
    Jerome A Dempsey; Fiscal Year: 2010
    ..Accordingly, we hypothesize that correcting respiratory system instability will improve airway patency and breathing for those patients who are characterized by a ..
  66. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    ....
  67. Azithromycin to prevent BPD in Ureaplasma-infected Preterms: Single Dose PK study
    Rose Viscardi; Fiscal Year: 2009
    ..This study will evaluate the safety and pharmacokinetics (how the body processes the drug) of the antibiotic azithromycin in preterm babies at risk for the Ureaplasma infection and the complication BPD. ..
  68. Transmission and the respiratory tract in cryptosporidiosis
    Jeffrey Griffiths; Fiscal Year: 2007
    ..This study is important to public health because it may help us to understand if the parasite also causes a lung infection in children. [unreadable] [unreadable] [unreadable]..
  69. Function of NALT in nasal immunization to heterotypic strains of influenza
    Troy D Randall; Fiscal Year: 2010
    ..This information will be essential for the development of vaccines that promote long-lasting cross-reactive immunity to influenza, a virus that continues to be an emerging infectious disease. ..
  70. LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLE
    JOHN COLERIDGE; Fiscal Year: 1992
    ....
  71. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..abstract_text> ..
  72. Cell Entry of Human Metapneumovirus
    John Williams; Fiscal Year: 2009
    ..These studies will increase understanding of how hMPV causes disease in humans, and may help develop targets for antiviral medicines and vaccines. ..
  73. Acoustic and Respiratory System Correlates of Pausing
    Janet Slifka; Fiscal Year: 2009
    ..Current models of speech production assign a largely passive role to the respiratory system, yet preliminary data indicate that pauses are actively generated by re-adjustments of the respiratory ..
  74. LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS
    CARROLL CROSS; Fiscal Year: 2000
    ..This information is likely to increase our understanding of lung injury due to inhalation of air pollutants, and will enable development of strategies to prevent lung injury by inhaled oxidants. ..
  75. Novel approaches to evaluate carbon nanotube health impacts
    KENT ED PINKERTON; Fiscal Year: 2010
    ..Inhalation of SWCNTs causes cellular injury, oxidative stress, and changes in biochemical homeostasis in the respiratory system of exposed animals;(2) SWCNT particle retention patterns and impaired macrophage function are associated ..
  76. INNERVATION OF THE MAXILLARY SINUS IN RATS
    KEITH KAJANDER; Fiscal Year: 1993
    ..Inflammation of the upper respiratory system clearly is a major problem for many people in the United States...
  77. Role of Pertussis Toxin in Bordetella pertussis infection
    Nicholas H Carbonetti; Fiscal Year: 2010
    ..pertussis infection will increase our understanding of the pathogenic mechanisms of this organism, and may lead to novel therapeutic approaches to combat pertussis infection and disease. ..
  78. CORONAVIRUS-RECEPTOR INTERACTIONS
    Kathryn Holmes; Fiscal Year: 2003
    ..Inhibition of HCoV-229E respiratory infection by candidate drugs will be studied in transgenic mice that express the HCoV-229E receptor, hAPN, in the respiratory epithelium. ..
  79. Inhalation Dosimetry/Exposure Index of Fiber Aerosol
    Yung Sung Cheng; Fiscal Year: 2006
    ..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
  80. Improved Lung Delivery of Medical Aerosols through Enhanced Condensation Growth
    P Worth Longest; Fiscal Year: 2010
    ..The overall goal of this project is to develop a novel technology for the efficient delivery of inhaled medicines that minimizes deposition in the mouth and throat and maximizes deposition in the lungs. ..